IMP: Integrative Multi-species Prediction

Mus musculus

59 known processes

Impdh2

inosine 5'-phosphate dehydrogenase 2

(Aliases: IMPD)

Entrez: 23918
Ensembl: ENSMUSG00000062867
UniProtKB: P24547
UniProtKB: Q3UAT9

Process Predictions
Disease Predictions

Impdh2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
organic cyclic compound catabolic process	GO:1901361	295	0.521
nucleoside metabolic process	GO:0009116	246	0.466
dna dealkylation	GO:0035510	11	0.441
heterocycle catabolic process	GO:0046700	280	0.348
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.258
ribonucleoside metabolic process	GO:0009119	245	0.227
dna metabolic process	GO:0006259	303	0.225
mrna splicing via spliceosome	GO:0000398	43	0.213
ribonucleotide metabolic process	GO:0009259	291	0.185
cellular nitrogen compound catabolic process	GO:0044270	280	0.182
development of primary sexual characteristics	GO:0045137	143	0.182
purine containing compound metabolic process	GO:0072521	311	0.171
aromatic compound catabolic process	GO:0019439	286	0.169
spindle assembly involved in mitosis	GO:0090307	4	0.167
nucleoside triphosphate metabolic process	GO:0009141	230	0.166
purine ribonucleotide metabolic process	GO:0009150	290	0.165
nucleotide catabolic process	GO:0009166	217	0.156
nucleotide metabolic process	GO:0009117	332	0.153
ribonucleotide catabolic process	GO:0009261	208	0.152
dna repair	GO:0006281	107	0.152
mrna metabolic process	GO:0016071	84	0.148
glycosyl compound metabolic process	GO:1901657	246	0.140
cellular response to dna damage stimulus	GO:0006974	207	0.138
germ cell development	GO:0007281	185	0.137
translation	GO:0006412	93	0.128
mrna processing	GO:0006397	63	0.127
microtubule based process	GO:0007017	236	0.123
ribonucleoprotein complex subunit organization	GO:0071826	28	0.115
nucleobase containing small molecule metabolic process	GO:0055086	352	0.111
ribose phosphate metabolic process	GO:0019693	291	0.110
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.105
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	43	0.103
embryonic organ morphogenesis	GO:0048562	276	0.102
ribonucleoside catabolic process	GO:0042454	206	0.102
fertilization	GO:0009566	127	0.090
rna splicing	GO:0008380	54	0.090
cytoplasmic transport	GO:0016482	234	0.087
macromolecule methylation	GO:0043414	120	0.082
rna splicing via transesterification reactions	GO:0000375	43	0.082
organophosphate catabolic process	GO:0046434	232	0.080
organelle fission	GO:0048285	170	0.077
posttranscriptional regulation of gene expression	GO:0010608	155	0.076
rna processing	GO:0006396	105	0.073
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.071
nucleoside phosphate metabolic process	GO:0006753	338	0.066
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.066
purine ribonucleoside metabolic process	GO:0046128	241	0.064
mitotic cell cycle process	GO:1903047	159	0.063
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.063
nucleoside triphosphate catabolic process	GO:0009143	205	0.062
positive regulation of protein modification process	GO:0031401	299	0.061
endocytosis	GO:0006897	168	0.061	Fly
purine nucleoside catabolic process	GO:0006152	205	0.060
mitotic cell cycle	GO:0000278	195	0.058
gonad development	GO:0008406	141	0.057
microtubule cytoskeleton organization involved in mitosis	GO:1902850	4	0.056
maturation of ssu rrna	GO:0030490	1	0.056
toxin transport	GO:1901998	38	0.054
transcription coupled nucleotide excision repair	GO:0006283	2	0.053
regulation of mitotic cell cycle	GO:0007346	126	0.053
atp catabolic process	GO:0006200	55	0.052
nucleoside catabolic process	GO:0009164	206	0.052
microtubule cytoskeleton organization	GO:0000226	157	0.051
atp metabolic process	GO:0046034	75	0.050
purine nucleotide metabolic process	GO:0006163	302	0.049
regulation of cellular response to stress	GO:0080135	159	0.049
regulation of nucleoside metabolic process	GO:0009118	130	0.048
hematopoietic progenitor cell differentiation	GO:0002244	143	0.048
regulation of cellular amino acid metabolic process	GO:0006521	5	0.047
translational initiation	GO:0006413	24	0.047
binding of sperm to zona pellucida	GO:0007339	34	0.047
purine containing compound catabolic process	GO:0072523	213	0.046
carbohydrate derivative catabolic process	GO:1901136	231	0.046
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.046
regulation of nucleotide metabolic process	GO:0006140	169	0.045
chromatin organization	GO:0006325	206	0.045
i kappab kinase nf kappab signaling	GO:0007249	85	0.044
regulation of cellular ketone metabolic process	GO:0010565	66	0.043
nucleoside phosphate catabolic process	GO:1901292	222	0.043
snorna metabolic process	GO:0016074	1	0.042
cell cell recognition	GO:0009988	44	0.042
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.041
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.041
organelle assembly	GO:0070925	177	0.040
purine ribonucleoside catabolic process	GO:0046130	205	0.040
nucleoside monophosphate metabolic process	GO:0009123	85	0.040
purine nucleoside metabolic process	GO:0042278	241	0.036
mrna 3 end processing	GO:0031124	16	0.036
sperm egg recognition	GO:0035036	37	0.036
regulation of purine nucleotide catabolic process	GO:0033121	122	0.035
dna demethylation	GO:0080111	10	0.035
interspecies interaction between organisms	GO:0044419	83	0.035
regulation of membrane potential	GO:0042391	192	0.034
epithelial cell proliferation	GO:0050673	174	0.033
negative regulation of cell proliferation	GO:0008285	296	0.033
regulation of protein localization	GO:0032880	231	0.032
methylation	GO:0032259	134	0.032
positive regulation of hydrolase activity	GO:0051345	148	0.031
ion transmembrane transport	GO:0034220	361	0.031
cellular amine metabolic process	GO:0044106	44	0.030
positive regulation of rna splicing	GO:0033120	12	0.030
receptor mediated endocytosis	GO:0006898	51	0.030
genetic imprinting	GO:0071514	27	0.029
rna catabolic process	GO:0006401	29	0.029
ncrna processing	GO:0034470	26	0.029
cytoplasmic translational initiation	GO:0002183	3	0.029
cellular response to cytokine stimulus	GO:0071345	189	0.028
negative regulation of intracellular signal transduction	GO:1902532	167	0.028
cellular amino acid metabolic process	GO:0006520	103	0.028
negative regulation of cellular protein metabolic process	GO:0032269	247	0.027
rna 3 end processing	GO:0031123	20	0.027
purine ribonucleotide catabolic process	GO:0009154	208	0.026
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.026
amine metabolic process	GO:0009308	45	0.026
regulation of dna damage checkpoint	GO:2000001	3	0.026
generation of precursor metabolites and energy	GO:0006091	103	0.025
purine nucleotide biosynthetic process	GO:0006164	65	0.025
base excision repair	GO:0006284	9	0.025
leukocyte migration	GO:0050900	124	0.025
intracellular protein transport	GO:0006886	204	0.024
regulation of organelle organization	GO:0033043	289	0.024
demethylation	GO:0070988	23	0.024
regulation of intracellular protein transport	GO:0033157	82	0.024
cellular homeostasis	GO:0019725	240	0.024
oocyte anterior posterior axis specification	GO:0007314	2	0.023
cation transport	GO:0006812	399	0.023
negative regulation of translation	GO:0017148	22	0.023
regulation of feeding behavior	GO:0060259	3	0.023
regulation of cellular amine metabolic process	GO:0033238	20	0.023
negative regulation of mrna splicing via spliceosome	GO:0048025	12	0.023
dna modification	GO:0006304	50	0.023
placenta development	GO:0001890	140	0.023
negative regulation of molecular function	GO:0044092	258	0.022
gland development	GO:0048732	330	0.022
ribose phosphate biosynthetic process	GO:0046390	59	0.022
glycosyl compound catabolic process	GO:1901658	206	0.022
positive regulation of intracellular transport	GO:0032388	70	0.022
single fertilization	GO:0007338	82	0.022
transmembrane transport	GO:0055085	412	0.022
cellular ketone metabolic process	GO:0042180	84	0.022
positive regulation of translation	GO:0045727	19	0.022
cation homeostasis	GO:0055080	212	0.021
purine nucleotide catabolic process	GO:0006195	211	0.020
dna catabolic process	GO:0006308	19	0.020
regulation of cell cycle	GO:0051726	281	0.020
regulation of organ morphogenesis	GO:2000027	144	0.019
regulation of response to dna damage stimulus	GO:2001020	34	0.019
chromatin modification	GO:0016568	187	0.019
genitalia development	GO:0048806	37	0.019
ribonucleoside monophosphate catabolic process	GO:0009158	57	0.019
ossification	GO:0001503	216	0.018
female gamete generation	GO:0007292	74	0.018
positive regulation of organelle organization	GO:0010638	128	0.018
regulation of establishment of protein localization	GO:0070201	181	0.018
leukocyte apoptotic process	GO:0071887	71	0.018
nuclear export	GO:0051168	34	0.018
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.017
nuclear division	GO:0000280	158	0.017
regulation of intracellular transport	GO:0032386	159	0.017
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.017
divalent inorganic cation homeostasis	GO:0072507	138	0.017
protein localization to organelle	GO:0033365	185	0.017
leukocyte chemotaxis	GO:0030595	69	0.017
dna conformation change	GO:0071103	37	0.016
regulation of rna splicing	GO:0043484	37	0.016
regulation of mrna processing	GO:0050684	41	0.016
regulation of hydrolase activity	GO:0051336	246	0.016
body morphogenesis	GO:0010171	45	0.016
sensory organ morphogenesis	GO:0090596	242	0.016
glial cell differentiation	GO:0010001	131	0.016
positive regulation of cellular amine metabolic process	GO:0033240	5	0.016
carbohydrate derivative biosynthetic process	GO:1901137	183	0.016
regulation of kinase activity	GO:0043549	249	0.015
cation transmembrane transport	GO:0098655	266	0.015
negative regulation of cell cycle	GO:0045786	123	0.015
cell recognition	GO:0008037	83	0.015
negative regulation of kinase activity	GO:0033673	81	0.015
macromolecule catabolic process	GO:0009057	281	0.015
regulation of mrna splicing via spliceosome	GO:0048024	32	0.015
regulation of mrna metabolic process	GO:1903311	43	0.015
regulation of translation	GO:0006417	71	0.014
camera type eye development	GO:0043010	266	0.014
purine ribonucleoside monophosphate catabolic process	GO:0009169	57	0.014
segmentation	GO:0035282	93	0.014
mitotic nuclear division	GO:0007067	48	0.014
cell chemotaxis	GO:0060326	81	0.014
stem cell differentiation	GO:0048863	268	0.014
regulation of cell cycle process	GO:0010564	160	0.014
positive regulation of cell death	GO:0010942	224	0.014
ras protein signal transduction	GO:0007265	77	0.013
oocyte construction	GO:0007308	2	0.013
gtp catabolic process	GO:0006184	143	0.013
gtp metabolic process	GO:0046039	144	0.013
regulation of purine nucleotide metabolic process	GO:1900542	169	0.013
negative regulation of protein phosphorylation	GO:0001933	126	0.013
axon guidance	GO:0007411	141	0.013	Fly
regulation of protein binding	GO:0043393	60	0.013
regulation of ion transport	GO:0043269	215	0.013
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045899	2	0.013
negative regulation of mrna metabolic process	GO:1903312	13	0.013
regulation of gtp catabolic process	GO:0033124	113	0.012
pharynx development	GO:0060465	1	0.012
respiratory system development	GO:0060541	190	0.012
chemotaxis	GO:0006935	247	0.012	Fly
organonitrogen compound biosynthetic process	GO:1901566	192	0.012
myeloid leukocyte migration	GO:0097529	57	0.012
dna templated transcriptional preinitiation complex assembly	GO:0070897	4	0.012
nitrogen compound transport	GO:0071705	271	0.011
epithelial tube morphogenesis	GO:0060562	303	0.011
positive regulation of nucleoside metabolic process	GO:0045979	91	0.011
peptidyl amino acid modification	GO:0018193	336	0.011
regulation of protein kinase activity	GO:0045859	232	0.011
response to light stimulus	GO:0009416	135	0.011
peptidyl lysine modification	GO:0018205	77	0.011
positive regulation of nucleotide metabolic process	GO:0045981	114	0.011
blood circulation	GO:0008015	195	0.011
rna polymerase ii transcriptional preinitiation complex assembly	GO:0051123	3	0.011
positive regulation of dna repair	GO:0045739	3	0.011
peptidyl tyrosine modification	GO:0018212	145	0.011
dna dependent dna replication maintenance of fidelity	GO:0045005	3	0.011
viral process	GO:0016032	41	0.011
female sex differentiation	GO:0046660	84	0.011
cellular response to lipid	GO:0071396	145	0.010
organonitrogen compound catabolic process	GO:1901565	264	0.010
viral life cycle	GO:0019058	36	0.010
protein localization to nucleus	GO:0034504	121	0.010
negative regulation of rna splicing	GO:0033119	12	0.010
positive regulation of cell cycle phase transition	GO:1901989	17	0.010
pole plasm assembly	GO:0007315	2	0.010
ribonucleotide biosynthetic process	GO:0009260	59	0.010
histone modification	GO:0016570	159	0.010
leukocyte differentiation	GO:0002521	342	0.010
molting cycle	GO:0042303	90	0.010
positive regulation of programmed cell death	GO:0043068	218	0.010

Impdh2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.016
disease of anatomical entity	DOID:7	0.016
central nervous system disease	DOID:331	0.016
disease of cellular proliferation	DOID:14566	0.011
cancer	DOID:162	0.011
organ system cancer	DOID:0050686	0.011
neurodegenerative disease	DOID:1289	0.011

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