Mus musculus

22 known processes

Npc2

Niemann Pick type C2

(Aliases: HE1,2700012J19Rik,AU045843,AA408070)

Npc2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
sphingolipid catabolic processGO:003014970.240
cation homeostasisGO:00550802120.191
membrane lipid catabolic processGO:004646680.148
sphingoid metabolic processGO:004651950.146
vacuole organizationGO:0007033380.139
sphingolipid metabolic processGO:0006665450.130
maintenance of locationGO:0051235890.124
glycolipid metabolic processGO:0006664250.123
membrane lipid metabolic processGO:0006643530.117
ceramide catabolic processGO:004651470.117
anatomical structure homeostasisGO:00602491450.113
ion transmembrane transportGO:00342203610.113
glycosphingolipid catabolic processGO:004647950.109
carbohydrate derivative catabolic processGO:19011362310.109
cellular homeostasisGO:00197252400.105
regulation of secretionGO:00510462740.100
regulation of membrane potentialGO:00423911920.094
t cell activationGO:00421102890.093
metal ion homeostasisGO:00550651890.092
regulation of peptidase activityGO:0052547960.092
carbohydrate catabolic processGO:0016052320.091
oxidation reduction processGO:00551143420.081
lipid localizationGO:00108761260.077
cellular chemical homeostasisGO:00550822150.076
glucose homeostasisGO:00425931280.075
cellular divalent inorganic cation homeostasisGO:00725031270.075
carbohydrate metabolic processGO:00059752300.073
wound healingGO:00420601570.068
glycolipid catabolic processGO:001937750.067
carbohydrate homeostasisGO:00335001280.065
protein maturationGO:00516041760.062
calcium ion homeostasisGO:00550741270.061
apoptotic signaling pathwayGO:00971903060.060
monosaccharide metabolic processGO:00059961060.059
sequestering of metal ionGO:0051238190.058
immune effector processGO:00022523210.058
vesicle organizationGO:0016050600.055
rho protein signal transductionGO:0007266320.053
cellular metal ion homeostasisGO:00068751510.052
regulation of vesicle mediated transportGO:00606271390.050
germ cell developmentGO:00072811850.047
regulation of angiotensin levels in bloodGO:000200240.047
transmembrane transportGO:00550854120.044
ceramide metabolic processGO:0006672310.043
muscle tissue developmentGO:00605373080.042
positive regulation of cell deathGO:00109422240.042
positive regulation of programmed cell deathGO:00430682180.041
cation transportGO:00068123990.041
liposaccharide metabolic processGO:1903509270.041
regulation of apoptotic signaling pathwayGO:20012331970.040
myotube cell developmentGO:0014904600.040
regulation of intrinsic apoptotic signaling pathwayGO:2001242610.039
lytic vacuole organizationGO:0080171210.039
cell killingGO:0001906670.038
neuromuscular processGO:0050905990.037
lipid transportGO:0006869980.036
multicellular organismal homeostasisGO:00488711640.036
endocytosisGO:00068971680.036
divalent inorganic cation homeostasisGO:00725071380.035
regulation of cell shapeGO:0008360390.035
establishment of protein localization to membraneGO:0090150540.035
natural killer cell degranulationGO:004332030.035
multi multicellular organism processGO:00447061090.035
release of sequestered calcium ion into cytosolGO:0051209420.034
cellular ketone metabolic processGO:0042180840.034
neuromuscular process controlling balanceGO:0050885590.033
response to extracellular stimulusGO:00099911270.033
antigen processing and presentationGO:0019882470.033
adult locomotory behaviorGO:0008344910.033
oligosaccharide metabolic processGO:0009311110.032
endomembrane system organizationGO:00102561470.032
regulation of hydrolase activityGO:00513362460.031
actin filament branchingGO:009013510.031
locomotory behaviorGO:00076261950.030
hexose metabolic processGO:0019318980.030
calcium ion transportGO:00068161590.030
heterocycle catabolic processGO:00467002800.030
tissue homeostasisGO:00018941150.030
ras protein signal transductionGO:0007265770.030
morphogenesis of a branching epitheliumGO:00611381930.030
arp2 3 complex mediated actin nucleationGO:003431430.030
fertilizationGO:00095661270.030
angiogenesisGO:00015252010.029
positive regulation of apoptotic processGO:00430652170.029
positive regulation of secretionGO:00510471300.029
sequestering of calcium ionGO:0051208180.029
blood vessel morphogenesisGO:00485142850.029
organelle fusionGO:0048284280.029
multi organism reproductive behaviorGO:0044705290.029
cellular response to external stimulusGO:0071496880.028
reactive oxygen species metabolic processGO:0072593840.028
generation of precursor metabolites and energyGO:00060911030.028
carbohydrate biosynthetic processGO:0016051740.028
cellular protein complex assemblyGO:00436231160.028
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630570.028
intrinsic apoptotic signaling pathwayGO:00971931320.028
cellular response to hormone stimulusGO:00328701500.027
divalent inorganic cation transportGO:00725111780.027
regulation of cellular amino acid metabolic processGO:000652150.027
protein processingGO:00164851630.027
leukocyte mediated cytotoxicityGO:0001909620.027
positive regulation of cytosolic calcium ion concentrationGO:0007204650.027
water soluble vitamin biosynthetic processGO:004236430.027
response to inorganic substanceGO:0010035960.026
organonitrogen compound catabolic processGO:19015652640.026
male courtship behaviorGO:000804920.026
lysosome organizationGO:0007040210.026
multicellular organismal signalingGO:0035637910.025
purine nucleoside triphosphate metabolic processGO:00091442260.025
regulation of neuron apoptotic processGO:00435231220.025
adaptive immune responseGO:00022501550.025
cellular ion homeostasisGO:00068731650.025
positive regulation of cellular amine metabolic processGO:003324050.025
nucleoside metabolic processGO:00091162460.025
lymphocyte proliferationGO:00466511640.024
divalent metal ion transportGO:00708381720.024
adult behaviorGO:00305341350.024
cellular lipid catabolic processGO:0044242520.024
exocytosisGO:00068871210.024
macromolecule catabolic processGO:00090572810.023
striated muscle tissue developmentGO:00147062930.023
lipid biosynthetic processGO:00086101790.022
cell growthGO:00160491300.022
leukocyte homeostasisGO:0001776790.022
phagosome maturationGO:009038240.022
developmental maturationGO:00217001930.022
astrocyte cell migrationGO:004361530.022
homeostasis of number of cellsGO:00488722100.022
purine nucleoside catabolic processGO:00061522050.022
regulation of cytoplasmic transportGO:19036491120.022
positive regulation of lymphocyte activationGO:00512511400.022
membrane depolarizationGO:0051899640.021
response to nutrient levelsGO:00316671090.021
neuronal action potentialGO:0019228540.021
posttranscriptional regulation of gene expressionGO:00106081550.021
organelle assemblyGO:00709251770.021
hexose catabolic processGO:001932030.021
skeletal muscle fiber developmentGO:0048741580.020
regulation of angiotensin metabolic processGO:006017740.020
striated muscle cell developmentGO:00550021250.020
regulation of proteolysisGO:00301621640.020
negative regulation of cellular protein metabolic processGO:00322692470.020
membrane protein proteolysisGO:0033619100.020
cellular calcium ion homeostasisGO:00068741190.020
guanosine containing compound metabolic processGO:19010681440.020
male gamete generationGO:00482322850.020
regulation of cell projection organizationGO:00313442060.020
oligosaccharide catabolic processGO:000931320.020
ribonucleotide metabolic processGO:00092592910.020
male gonad developmentGO:0008584880.020
small molecule biosynthetic processGO:00442831320.020
regulation of protein kinase activityGO:00458592320.020
organic hydroxy compound transportGO:0015850930.020
lysosomal transportGO:0007041100.019
fat cell differentiationGO:00454441600.019
small gtpase mediated signal transductionGO:0007264970.019
cytoplasmic transportGO:00164822340.019
actin cytoskeleton organizationGO:00300362200.019
sensory system developmentGO:004888030.019
plasma membrane organizationGO:0007009900.019
cytosolic calcium ion transportGO:0060401480.019
t cell mediated immunityGO:0002456500.019
ceramide biosynthetic processGO:0046513200.019
lipid storageGO:0019915360.019
regulation of cellular ketone metabolic processGO:0010565660.018
positive regulation of cell activationGO:00508671580.018
negative regulation of neuron deathGO:1901215980.018
positive regulation of t cell activationGO:00508701010.018
muscle cell developmentGO:00550011330.018
positive regulation of cell projection organizationGO:0031346950.018
regulation of hormone levelsGO:00108172110.018
sensory perceptionGO:00076002450.018
purine ribonucleoside triphosphate catabolic processGO:00092071990.018
reactive oxygen species biosynthetic processGO:190340980.018
phagolysosome assemblyGO:000184530.018
leukocyte mediated immunityGO:00024431740.018
regulation of cell activationGO:00508652890.018
action potentialGO:0001508780.018
lung developmentGO:00303241640.018
nuclear transportGO:00511691390.018
nucleoside triphosphate metabolic processGO:00091412300.017
purine ribonucleoside triphosphate metabolic processGO:00092052200.017
positive regulation of cell motilityGO:20001471160.017
cytosolic calcium ion homeostasisGO:0051480700.017
epithelial cell proliferationGO:00506731740.017
mapk cascadeGO:00001652810.017
protein oligomerizationGO:0051259670.017
antigen processing and presentation of exogenous antigenGO:0019884260.017
nucleotide metabolic processGO:00091173320.017
central nervous system morphogenesisGO:002155120.017
cellular carbohydrate metabolic processGO:00442621190.017
regulation of calcium ion transportGO:0051924690.017
cellular response to nutrient levelsGO:0031669640.017
regulation of lymphocyte activationGO:00512492400.017
sensory perception of soundGO:0007605970.017
coagulationGO:0050817780.017
vesicle fusionGO:0006906160.016
extrinsic apoptotic signaling pathwayGO:00971911260.016
skeletal muscle organ developmentGO:00605381630.016
amine metabolic processGO:0009308450.016
nucleobase containing small molecule metabolic processGO:00550863520.016
regulation of endopeptidase activityGO:0052548890.016
positive regulation of cellular component biogenesisGO:0044089940.016
cellular amine metabolic processGO:0044106440.016
response to monosaccharideGO:0034284670.016
regulation of protein processingGO:0070613960.016
neuron deathGO:00709971540.016
organism emergence from protective structureGO:007168440.016
organic acid transportGO:00158491010.016
membrane organizationGO:00610242450.016
ossificationGO:00015032160.016
blastocyst developmentGO:0001824800.016
energy derivation by oxidation of organic compoundsGO:0015980770.016
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.016
multicellular organismal catabolic processGO:004424370.016
regulation of intracellular transportGO:00323861590.016
purine nucleoside triphosphate catabolic processGO:00091462030.016
regulation of ion transportGO:00432692150.016
multicellular organismal metabolic processGO:0044236280.016
lipid catabolic processGO:0016042690.016
purine ribonucleoside metabolic processGO:00461282410.016
respiratory system developmentGO:00605411900.015
aminoglycan metabolic processGO:0006022340.015
regulation of homeostatic processGO:00328441820.015
positive regulation of apoptotic signaling pathwayGO:2001235950.015
multi organism behaviorGO:0051705620.015
myelinationGO:0042552740.015
negative regulation of vesicle fusionGO:003133910.015
lamellipodium morphogenesisGO:007267350.015
lymphocyte mediated immunityGO:00024491390.015
glycosyl compound catabolic processGO:19016582060.015
reactive nitrogen species metabolic processGO:200105700.015
positive regulation of hydrolase activityGO:00513451480.015
dephosphorylationGO:00163111290.015
innate immune responseGO:00450871570.015
glycosylceramide metabolic processGO:000667740.015
protein localization to cell leading edgeGO:190246310.015
microtubule based processGO:00070172360.014
urogenital system developmentGO:00016552610.014
anion transportGO:00068201770.014
glycosphingolipid metabolic processGO:0006687180.014
blood circulationGO:00080151950.014
neuromuscular process controlling postureGO:0050884140.014
organic anion transportGO:00157111370.014
superoxide metabolic processGO:0006801270.014
skeletal system developmentGO:00015013560.014
male sex differentiationGO:00466611090.014
epithelium migrationGO:0090132630.014
reproductive behaviorGO:0019098320.014
regulation of cellular response to stressGO:00801351590.014
bone developmentGO:00603481200.014
negative regulation of response to oxidative stressGO:1902883100.014
regulation of cell motilityGO:20001452360.014
learning or memoryGO:00076111480.013
nucleoside phosphate catabolic processGO:19012922220.013
t cell proliferationGO:00420981200.013
ribonucleoside metabolic processGO:00091192450.013
nucleoside triphosphate catabolic processGO:00091432050.013
neuron apoptotic processGO:00514021420.013
protein localization to plasma membraneGO:0072659570.013
positive regulation of peptidase activityGO:0010952490.013
cellular response to extracellular stimulusGO:0031668810.013
organonitrogen compound biosynthetic processGO:19015661920.013
cellular response to dna damage stimulusGO:00069742070.013
protein localization to membraneGO:00726571080.013
regulation of leukocyte mediated immunityGO:00027031040.013
l ascorbic acid metabolic processGO:001985240.013
regulation of cellular amine metabolic processGO:0033238200.013
regulation of metal ion transportGO:00109591060.013
regulation of epithelial cell proliferationGO:00506781410.013
extracellular structure organizationGO:00430621480.013
inflammatory responseGO:00069542440.013
regulation of transferase activityGO:00513382630.013
regulation of t cell activationGO:00508631700.013
aromatic compound catabolic processGO:00194392860.013
oogenesisGO:0048477560.013
organophosphate catabolic processGO:00464342320.013
regulation of body fluid levelsGO:00508781620.013
phospholipid metabolic processGO:0006644870.013
response to organic cyclic compoundGO:00140701980.012
response to acid chemicalGO:00011011110.012
negative regulation of molecular functionGO:00440922580.012
galactose metabolic processGO:000601240.012
negative regulation of proteolysisGO:0045861740.012
organelle fissionGO:00482851700.012
gtp metabolic processGO:00460391440.012
meiotic cell cycleGO:00513211220.012
single fertilizationGO:0007338820.012
glycosaminoglycan metabolic processGO:0030203340.012
positive regulation of mitochondrial calcium ion concentrationGO:005156130.012
ribonucleoside triphosphate catabolic processGO:00092031990.012
cellular response to oxidative stressGO:0034599760.012
regulation of lamellipodium morphogenesisGO:200039210.012
developmental growth involved in morphogenesisGO:00605601380.012
cilium morphogenesisGO:00602711020.012
cellular component assembly involved in morphogenesisGO:00109271390.012
development of primary sexual characteristicsGO:00451371430.012
cellular response to glucose stimulusGO:0071333450.012
negative regulation of wnt signaling pathwayGO:0030178730.012
ketone catabolic processGO:004218230.012
t cell differentiationGO:00302171740.012
sensory organ morphogenesisGO:00905962420.012
fatty acid transportGO:0015908280.012
epithelial tube branching involved in lung morphogenesisGO:0060441280.012
regulation of blood pressureGO:0008217930.012
nucleoside catabolic processGO:00091642060.012
engulfment of apoptotic cellGO:004365230.012
nuclear divisionGO:00002801580.012
response to drugGO:0042493750.012
axon ensheathmentGO:0008366760.012
lymphocyte homeostasisGO:0002260640.011
transmission of nerve impulseGO:0019226760.011
cation transmembrane transportGO:00986552660.011
chemotaxisGO:00069352470.011
lamellipodium organizationGO:0097581290.011
regulation of cell migrationGO:00303342190.011
negative regulation of protein processingGO:0010955790.011
negative regulation of protein maturationGO:1903318790.011
circulatory system processGO:00030131970.011
cellular glucose homeostasisGO:0001678520.011
regulation of calcium ion transport into cytosolGO:0010522310.011
cellular response to growth factor stimulusGO:00713631970.011
organic hydroxy compound metabolic processGO:19016152030.011
sensory perception of mechanical stimulusGO:00509541070.011
nucleocytoplasmic transportGO:00069131390.011
purine nucleotide metabolic processGO:00061633020.011
negative regulation of response to woundingGO:1903035770.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.011
mitochondrion organizationGO:00070051340.011
regulation of protein complex assemblyGO:0043254830.011
positive regulation of necrotic cell deathGO:001094010.011
leukocyte differentiationGO:00025213420.011
epithelial tube morphogenesisGO:00605623030.011
embryonic organ morphogenesisGO:00485622760.011
regulation of heart contractionGO:0008016770.011
regulation of neuron projection developmentGO:00109751690.011
protein catabolic processGO:00301632210.011
antigen processing and presentation of peptide antigenGO:0048002290.011
organophosphate biosynthetic processGO:00904071220.011
extracellular matrix organizationGO:00301981470.011
organic cyclic compound catabolic processGO:19013612950.011
cofactor transportGO:005118140.011
spermatogenesisGO:00072832840.011
positive regulation of lamellipodium organizationGO:190274530.011
regulation of ossificationGO:00302781120.011
nucleotide catabolic processGO:00091662170.011
lung morphogenesisGO:0060425500.011
cellular amino acid metabolic processGO:00065201030.011
cellular response to organonitrogen compoundGO:00714171450.011
female gamete generationGO:0007292740.011
lymphocyte differentiationGO:00300982420.011
cell type specific apoptotic processGO:00972852680.010
regulation of leukocyte apoptotic processGO:2000106560.010
regulation of actin nucleationGO:005112540.010
purine ribonucleotide catabolic processGO:00091542080.010
regulation of protein catabolic processGO:00421761080.010
regulation of arp2 3 complex mediated actin nucleationGO:003431510.010
myotube differentiationGO:00149021050.010
positive regulation of protein modification processGO:00314012990.010
connective tissue developmentGO:00614481790.010

Npc2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
lysosomal storage diseaseDOID:321100.878
Human
inherited metabolic disorderDOID:65500.878
Human
disease of metabolismDOID:001466700.878
Human
lipid storage diseaseDOID:945500.878
Human
disease of anatomical entityDOID:700.321
Human
nervous system diseaseDOID:86300.321
brain diseaseDOID:93600.321
central nervous system diseaseDOID:33100.321
sphingolipidosisDOID:192700.300
Human
cerebral degenerationDOID:144300.120
epilepsy syndromeDOID:182600.093
electroclinical syndromeDOID:005070100.093
progressive myoclonus epilepsyDOID:89100.040
variable age at onset electroclinical syndromeDOID:005070600.040
immune system diseaseDOID:291400.031
Human
neuronal ceroid lipofuscinosisDOID:1450300.018
lymphatic system diseaseDOID:7500.014
Human
neurodegenerative diseaseDOID:128900.013
primary immunodeficiency diseaseDOID:61200.012
acquired metabolic diseaseDOID:006015800.011