Mus musculus

141 known processes

Npc1

Niemann Pick type C1

(Aliases: D18Ertd723e,C85354,lcsd,spm,D18Ertd139e,nmf164,A430089E03Rik)

Npc1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
intracellular cholesterol transportGO:003236730.999
positive regulation of sterol transportGO:003237390.999
sterol homeostasisGO:0055092450.999
positive regulation of cholesterol transportGO:003237690.997
protein lipid complex subunit organizationGO:0071825120.995
cholesterol homeostasisGO:0042632440.987
regulation of sterol transportGO:0032371170.986
Fly
phospholipid transfer to membraneGO:000664920.984
cholesterol transportGO:0030301380.983
intracellular lipid transportGO:003236530.982
cholesterol effluxGO:0033344240.975
sterol metabolic processGO:0016125580.975
Fly
regulation of plasma lipoprotein particle levelsGO:0097006230.968
steroid metabolic processGO:00082021190.966
reverse cholesterol transportGO:004369160.965
intracellular sterol transportGO:003236630.965
plasma lipoprotein particle organizationGO:0071827110.956
cholesterol metabolic processGO:0008203560.956
positive regulation of cholesterol effluxGO:001087590.942
sterol transportGO:0015918380.919
organic hydroxy compound transportGO:0015850930.910
lipid transportGO:0006869980.910
lipid homeostasisGO:0055088630.908
regulation of cholesterol transportGO:0032374170.904
Fly
lipid localizationGO:00108761260.890
lysosome organizationGO:0007040210.859
high density lipoprotein particle assemblyGO:003438030.857
glycerolipid metabolic processGO:00464861220.855
regulation of cellular ketone metabolic processGO:0010565660.828
alcohol metabolic processGO:00060661160.804
Fly
regulation of beta amyloid clearanceGO:190022110.774
positive regulation of lipid transportGO:0032370220.759
positive regulation of reverse cholesterol transportGO:190306410.751
lipid modificationGO:0030258650.743
cellular ketone metabolic processGO:0042180840.743
Fly
positive regulation of beta amyloid clearanceGO:190022310.740
cognitionGO:00508901490.728
regulation of insulin receptor signaling pathwayGO:0046626210.716
phospholipid transportGO:0015914210.708
energy derivation by oxidation of organic compoundsGO:0015980770.699
regulation of phospholipid effluxGO:190299420.696
regulation of engulfment of apoptotic cellGO:190107420.668
phospholipid effluxGO:003370030.663
cdc42 protein signal transductionGO:003248800.643
purine containing compound metabolic processGO:00725213110.642
regulation of cholesterol effluxGO:0010874130.637
regulation of cellular amino acid metabolic processGO:000652150.633
phospholipid metabolic processGO:0006644870.631
organophosphate ester transportGO:0015748280.627
glycoprotein biosynthetic processGO:0009101890.625
lipid biosynthetic processGO:00086101790.604
Fly
regulation of planar cell polarity pathway involved in outflow tract morphogenesisGO:200016310.597
cellular lipid metabolic processGO:00442553230.597
positive regulation of triglyceride metabolic processGO:009020890.595
negative regulation of planar cell polarity pathway involved in pericardium morphogenesisGO:200016610.593
regulation of feeding behaviorGO:006025930.583
lytic vacuole organizationGO:0080171210.574
oxidation reduction processGO:00551143420.561
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesisGO:200016210.561
neuron apoptotic processGO:00514021420.558
respiratory system developmentGO:00605411900.553
regulation of presynaptic membrane organizationGO:190162930.548
anion transportGO:00068201770.541
insulin receptor signaling pathwayGO:0008286490.539
organic hydroxy compound metabolic processGO:19016152030.538
beta amyloid clearanceGO:009724220.532
generation of precursor metabolites and energyGO:00060911030.530
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.526
endocytosisGO:00068971680.521
learning or memoryGO:00076111480.513
formation of radial glial scaffoldsGO:002194340.505
positive regulation of lipoprotein lipase activityGO:005100630.502
regulation of cellular catabolic processGO:00313292420.501
regulation of planar cell polarity pathway involved in ventricular septum morphogenesisGO:200014810.496
cellular amine metabolic processGO:0044106440.491
acylglycerol metabolic processGO:0006639550.487
regulation of planar cell polarity pathway involved in heart morphogenesisGO:200015910.485
regulation of neuron deathGO:19012141340.482
triglyceride metabolic processGO:0006641510.480
neuron deathGO:00709971540.474
canonical wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart developmentGO:006131010.469
regulation of cholesterol metabolic processGO:0090181140.467
anatomical structure homeostasisGO:00602491450.459
nucleotide metabolic processGO:00091173320.452
plasma lipoprotein particle remodelingGO:003436960.452
regulation of lipid storageGO:0010883200.452
positive regulation of lipid metabolic processGO:0045834400.451
regulation of cellular amine metabolic processGO:0033238200.449
neutral lipid metabolic processGO:0006638570.445
organophosphate biosynthetic processGO:00904071220.444
acylglycerol biosynthetic processGO:0046463180.443
water homeostasisGO:0030104270.443
plasma lipoprotein particle clearanceGO:0034381130.442
triglyceride homeostasisGO:0070328150.442
plasma lipoprotein particle assemblyGO:003437760.438
gland developmentGO:00487323300.429
regulation of fatty acid metabolic processGO:0019217280.429
carbohydrate derivative biosynthetic processGO:19011371830.421
ribose phosphate biosynthetic processGO:0046390590.421
regulation of lipid biosynthetic processGO:0046890540.419
amine metabolic processGO:0009308450.419
vacuole organizationGO:0007033380.416
regulation of androgen receptor signaling pathwayGO:006076530.406
negative regulation of protein metabolic processGO:00512482820.404
glycerophospholipid metabolic processGO:0006650710.399
ion transmembrane transportGO:00342203610.392
amide transportGO:00428861380.388
regulation of amyloid precursor protein catabolic processGO:190299180.386
purine containing compound biosynthetic processGO:0072522700.383
sulfur compound biosynthetic processGO:0044272370.383
cellular response to peptide hormone stimulusGO:0071375920.381
regulation of cholesterol biosynthetic processGO:004554080.378
glycerolipid biosynthetic processGO:0045017500.377
negative regulation of sterol transportGO:003237240.374
low density lipoprotein particle clearanceGO:003438380.371
cellular amino acid metabolic processGO:00065201030.370
purine nucleotide biosynthetic processGO:0006164650.369
cyclic purine nucleotide metabolic processGO:0052652430.366
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesisGO:200014910.353
proteoglycan biosynthetic processGO:0030166200.350
negative regulation of platelet derived growth factor receptor beta signaling pathwayGO:200058720.350
positive regulation of insulin receptor signaling pathwayGO:004662840.349
g protein coupled receptor signaling pathwayGO:00071862430.348
response to low density lipoprotein particleGO:005509820.348
response to peptide hormoneGO:00434341270.343
positive regulation of lipid biosynthetic processGO:0046889180.335
cyclic nucleotide biosynthetic processGO:0009190440.335
nucleoside phosphate metabolic processGO:00067533380.334
cholesterol storageGO:001087840.331
regulation of planar cell polarity pathway involved in pericardium morphogenesisGO:200016510.331
negative regulation of planar cell polarity pathway involved in heart morphogenesisGO:200016010.330
negative regulation of cellular amide metabolic processGO:003424940.328
regulation of lipid transportGO:0032368360.326
Fly
negative regulation of cell proliferationGO:00082852960.321
response to nutrient levelsGO:00316671090.319
negative regulation of cholesterol transportGO:003237540.319
positive regulation of fatty acid oxidationGO:004632140.318
memoryGO:0007613580.317
cell proliferation in hindbrainGO:0021534100.315
regulation of endocytosisGO:0030100690.313
organic anion transportGO:00157111370.313
organonitrogen compound biosynthetic processGO:19015661920.312
cholesterol esterificationGO:003443530.310
regulation of phospholipid transportGO:200113840.308
associative learningGO:0008306610.307
amyloid precursor protein biosynthetic processGO:004298330.301
glutamine family amino acid metabolic processGO:0009064150.299
engulfment of apoptotic cellGO:004365230.298
regulation of amyloid precursor protein biosynthetic processGO:004298430.298
transmembrane transportGO:00550854120.294
negative regulation of planar cell polarity pathway involved in outflow tract morphogenesisGO:200016410.292
cell type specific apoptotic processGO:00972852680.291
positive regulation of cyclic nucleotide biosynthetic processGO:0030804240.290
lung developmentGO:00303241640.290
purine nucleotide metabolic processGO:00061633020.288
nitrogen compound transportGO:00717052710.287
acylglycerol homeostasisGO:0055090160.286
regulation of bindingGO:00510981110.274
regulation of lipid metabolic processGO:00192161180.273
cerebellum developmentGO:0021549770.268
ribose phosphate metabolic processGO:00196932910.267
male gamete generationGO:00482322850.267
Fly
negative regulation of cellular protein metabolic processGO:00322692470.266
maintenance of locationGO:0051235890.266
wnt signaling pathwayGO:00160551880.262
cellular response to peptideGO:1901653920.261
lipoprotein metabolic processGO:0042157430.260
ribonucleotide metabolic processGO:00092592910.259
hindbrain developmentGO:00309021280.257
connective tissue developmentGO:00614481790.255
response to starvationGO:0042594650.254
receptor mediated endocytosis of low density lipoprotein particle involved in cholesterol transportGO:009011810.254
regulation of fatty acid beta oxidationGO:003199810.252
axis elongation involved in somitogenesisGO:009024540.252
lipid catabolic processGO:0016042690.251
appendage developmentGO:00487361660.250
camp biosynthetic processGO:0006171310.246
antral ovarian follicle growthGO:000154750.245
small molecule biosynthetic processGO:00442831320.243
Fly
regulation of protein maturationGO:1903317960.243
forebrain developmentGO:00309003020.240
canonical wnt signaling pathwayGO:00600701300.239
negative regulation of cell sizeGO:004579230.239
cell proliferation involved in outflow tract morphogenesisGO:006132540.238
germ cell developmentGO:00072811850.238
Fly
regulation of phospholipase a2 activityGO:003242930.234
chemical homeostasis within a tissueGO:004887590.232
macromolecular complex remodelingGO:003436760.232
synapse organizationGO:00508081250.232
regulation of hydrolase activityGO:00513362460.231
regulation of triglyceride metabolic processGO:0090207170.231
synaptic transmissionGO:00072683290.230
embryonic viscerocranium morphogenesisGO:004870380.228
aminoglycan biosynthetic processGO:0006023150.228
dendrite developmentGO:00163581150.227
stem cell differentiationGO:00488632680.225
osteoblast developmentGO:0002076170.225
germ line stem cell divisionGO:004207820.224
ribonucleoside monophosphate metabolic processGO:0009161800.223
regulation of reverse cholesterol transportGO:190306210.223
positive regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:200006080.221
regulation of mapk cascadeGO:00434082480.218
tissue homeostasisGO:00018941150.216
ribonucleotide biosynthetic processGO:0009260590.215
nucleobase containing small molecule metabolic processGO:00550863520.214
defense response to other organismGO:00985421970.214
regulation of defense responseGO:00313472330.214
cellular polysaccharide metabolic processGO:0044264380.212
purine ribonucleotide biosynthetic processGO:0009152590.209
skeletal system developmentGO:00015013560.208
ribonucleoside metabolic processGO:00091192450.208
fat cell differentiationGO:00454441600.208
cholesterol biosynthetic processGO:0006695150.206
sterol transmembrane transportGO:003538220.206
regulation of fat cell differentiationGO:0045598810.205
energy reserve metabolic processGO:0006112390.204
respiratory tube developmentGO:00303231670.204
ribonucleoside triphosphate metabolic processGO:00091992200.204
endomembrane system organizationGO:00102561470.202
skeletal system morphogenesisGO:00487052030.202
nucleoside phosphate biosynthetic processGO:1901293790.201
bmp signaling pathwayGO:0030509930.201
cyclic nucleotide metabolic processGO:0009187590.199
regulation of lipase activityGO:0060191150.199
positive regulation of steroid biosynthetic processGO:001089340.199
regulation of phosphatidylcholine catabolic processGO:001089920.199
cellular response to lipopolysaccharideGO:0071222770.199
negative regulation of cellular amino acid metabolic processGO:004576300.198
nucleoside metabolic processGO:00091162460.197
multicellular organism growthGO:00352641610.195
positive regulation of phospholipid transportGO:200114040.195
embryonic skeletal system morphogenesisGO:0048704910.193
multicellular organismal homeostasisGO:00488711640.191
protein processingGO:00164851630.188
regulation of steroid biosynthetic processGO:0050810260.187
regulation of cell migrationGO:00303342190.185
regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesisGO:200016110.185
cell maturationGO:00484691270.183
positive regulation of phagocytosis engulfmentGO:006010030.183
developmental growth involved in morphogenesisGO:00605601380.182
regulation of transferase activityGO:00513382630.181
regulation of triglyceride biosynthetic processGO:0010866100.181
syncytium formation by plasma membrane fusionGO:0000768420.180
rhythmic processGO:00485111740.179
vesicle organizationGO:0016050600.177
spermatogenesisGO:00072832840.176
Fly
response to oxygen levelsGO:0070482620.176
kidney developmentGO:00018222130.175
embryonic appendage morphogenesisGO:00351131260.174
myeloid cell differentiationGO:00300992330.174
sterol esterificationGO:003443430.173
positive regulation of camp metabolic processGO:0030816190.173
positive regulation of triglyceride lipase activityGO:006136530.173
oocyte maturationGO:0001556180.170
regulation of homeostatic processGO:00328441820.170
positive regulation of presynaptic membrane organizationGO:190163110.170
regulation of translationGO:0006417710.170
negative regulation of defense responseGO:0031348770.170
protein lipidationGO:0006497280.169
regulation of cyclic nucleotide metabolic processGO:0030799400.169
embryonic organ morphogenesisGO:00485622760.168
regulation of body fluid levelsGO:00508781620.166
positive regulation of transferase activityGO:00513471670.165
camp metabolic processGO:0046058400.165
cellular biogenic amine metabolic processGO:0006576280.165
nucleoside monophosphate metabolic processGO:0009123850.164
embryonic skeletal system developmentGO:00487061200.163
cellular carbohydrate metabolic processGO:00442621190.163
nucleotide biosynthetic processGO:0009165780.162
response to peptideGO:19016521360.162
neural precursor cell proliferationGO:00613511210.162
midbrain developmentGO:0030901350.162
glucocorticoid metabolic processGO:000821190.161
ras protein signal transductionGO:0007265770.160
carbohydrate metabolic processGO:00059752300.159
regulation of protein kinase activityGO:00458592320.159
phospholipid catabolic processGO:000939550.157
lipoprotein biosynthetic processGO:0042158330.157
skin developmentGO:00435882200.156
hindbrain radial glia guided cell migrationGO:0021932120.154
regulation of organ morphogenesisGO:20000271440.152
cardiac muscle tissue developmentGO:00487381300.152
steroid esterificationGO:003443330.152
phagocytosisGO:0006909660.151
negative regulation of planar cell polarity pathway involved in neural tube closureGO:200016810.151
organ growthGO:00352651170.150
branching involved in mammary gland duct morphogenesisGO:0060444270.150
regulation of fatty acid oxidationGO:0046320100.150
cellular response to organonitrogen compoundGO:00714171450.150
positive regulation of apoptotic cell clearanceGO:200042730.149
chondroitin sulfate proteoglycan biosynthetic processGO:005065080.149
regulation of neuron apoptotic processGO:00435231220.149
olfactory learningGO:000835520.148
metencephalon developmentGO:0022037890.148
regulation of carbohydrate biosynthetic processGO:0043255400.146
peptide secretionGO:00027901140.146
bone developmentGO:00603481200.146
schwann cell proliferationGO:001401020.144
negative regulation of dendrite developmentGO:200017190.143
positive regulation of engulfment of apoptotic cellGO:190107610.143
positive regulation of mapk cascadeGO:00434101700.143
carbohydrate derivative catabolic processGO:19011362310.143
epidermis developmentGO:00085441870.142
regulation of synaptic growth at neuromuscular junctionGO:000858240.142
mapk cascadeGO:00001652810.142
glucose homeostasisGO:00425931280.141
cellular glucan metabolic processGO:0006073320.141
regulation of activin receptor signaling pathwayGO:0032925100.141
negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesisGO:200015110.140
long term memoryGO:0007616150.140
regulation of platelet derived growth factor receptor beta signaling pathwayGO:200058620.139
positive regulation of lipid storageGO:0010884100.138
small molecule catabolic processGO:0044282710.138
positive regulation of programmed cell deathGO:00430682180.138
positive regulation of carbohydrate metabolic processGO:0045913300.138
regulation of synaptic plasticityGO:0048167870.138
extrinsic apoptotic signaling pathwayGO:00971911260.138
urogenital system developmentGO:00016552610.137
glycosyl compound catabolic processGO:19016582060.136
glycoprotein metabolic processGO:00091001160.136
negative regulation of transforming growth factor beta receptor signaling pathwayGO:0030512260.135
regulation of planar cell polarity pathway involved in neural tube closureGO:200016710.135
regulation of vesicle mediated transportGO:00606271390.134
secretory granule organizationGO:0033363200.133
branching morphogenesis of an epithelial tubeGO:00487541590.133
cellular response to biotic stimulusGO:0071216920.133
glycosyl compound metabolic processGO:19016572460.131
sterol biosynthetic processGO:0016126170.131
polysaccharide metabolic processGO:0005976390.131
positive regulation of gene silencing by mirnaGO:200063710.130
negative regulation of glycoprotein metabolic processGO:190301930.130
canonical wnt signaling pathway involved in regulation of cell proliferationGO:004434030.129
regulation of wnt signaling pathwayGO:00301111230.128
regulation of systemic arterial blood pressureGO:0003073610.128
nucleoside triphosphate metabolic processGO:00091412300.128
response to extracellular stimulusGO:00099911270.128
positive regulation of kinase activityGO:00336741550.127
protein localization to nucleusGO:00345041210.127
regulation of organelle organizationGO:00330432890.126
positive regulation of fatty acid beta oxidationGO:003200010.126
purine ribonucleotide metabolic processGO:00091502900.126
segmentationGO:0035282930.125
protein kinase b signalingGO:0043491740.125
regulation of lymphocyte activationGO:00512492400.125
response to organic cyclic compoundGO:00140701980.124
negative regulation of inflammatory responseGO:0050728610.123
regulation of cholesterol esterificationGO:001087220.122
regulation of membrane potentialGO:00423911920.122
gene silencing by mirnaGO:0035195100.120
triglyceride biosynthetic processGO:0019432170.120
mitochondrion organizationGO:00070051340.120
response to cholesterolGO:007072340.120
cellular response to starvationGO:0009267570.120
positive regulation of fatty acid metabolic processGO:004592380.118
alcohol biosynthetic processGO:0046165430.118
response to decreased oxygen levelsGO:0036293590.118
negative regulation of lipid storageGO:001088860.118
negative regulation of cellular amine metabolic processGO:003323910.117
purine nucleoside monophosphate metabolic processGO:0009126810.117
macroautophagyGO:0016236210.117
cellular response to insulin stimulusGO:0032869780.117
negative regulation of phosphorus metabolic processGO:00105631840.116
regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesisGO:200015010.115
negative regulation of cellular component organizationGO:00511291940.115
protein modification by small protein conjugation or removalGO:00706472070.115
regulation of cellular response to stressGO:00801351590.115
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.115
non canonical wnt signaling pathwayGO:0035567330.115
cardiocyte differentiationGO:0035051870.114
regulation of camp biosynthetic processGO:0030817250.112
autophagyGO:0006914450.112
regulation of cellular component biogenesisGO:00440871810.109
positive regulation of fatty acid biosynthetic processGO:004572330.109
diencephalon developmentGO:0021536630.107
ovulation cycleGO:0042698590.107
feeding behaviorGO:0007631620.107
adult behaviorGO:00305341350.107
cellular nitrogen compound catabolic processGO:00442702800.106
translationGO:0006412930.106
negative regulation of neuron deathGO:1901215980.104
positive regulation of phospholipid effluxGO:190299520.104
regulation of nucleotide biosynthetic processGO:0030808340.104
membrane organizationGO:00610242450.103
Human
pole plasm assemblyGO:000731520.103
membrane depolarizationGO:0051899640.102
regulation of receptor activityGO:0010469410.102
posttranscriptional regulation of gene expressionGO:00106081550.102
regulation of blood pressureGO:0008217930.102
negative regulation of lipid transportGO:003236980.102
amyloid precursor protein catabolic processGO:0042987100.101
negative regulation of apoptotic signaling pathwayGO:20012341040.100
plasma membrane long chain fatty acid transportGO:001591110.100
locomotory behaviorGO:00076261950.100
muscle tissue developmentGO:00605373080.100
phospholipid homeostasisGO:005509160.100
positive regulation of protein phosphorylationGO:00019342420.099
wnt signaling pathway involved in somitogenesisGO:009024440.099
cellular protein catabolic processGO:00442571550.099
multicellular organismal response to stressGO:0033555620.099
cytoplasmic transportGO:00164822340.098
high density lipoprotein particle remodelingGO:003437540.098
negative regulation of beta amyloid formationGO:190243040.098
positive regulation of cell deathGO:00109422240.098
regulation of cellular ketone metabolic process by regulation of transcription from rna polymerase ii promoterGO:007236470.098
retina homeostasisGO:0001895230.098
lipoprotein catabolic processGO:004215970.098
purine ribonucleoside metabolic processGO:00461282410.097
wnt signaling pathway involved in forebrain neuroblast divisionGO:002187420.097
carboxylic acid transportGO:00469421000.097
cell proliferation in external granule layerGO:0021924100.096
epithelial cell proliferationGO:00506731740.096
digestive tract morphogenesisGO:00485461470.096
regulation of cholesterol homeostasisGO:200018890.095
regulation of phagocytosis engulfmentGO:006009950.095
synapse assemblyGO:0007416560.094
positive regulation of protein localization to cell surfaceGO:200001020.093
adaptive immune responseGO:00022501550.092
regulation of purine nucleotide metabolic processGO:19005421690.092
regulation of protein processingGO:0070613960.092
response to organonitrogen compoundGO:00102432460.091
amyloid precursor protein metabolic processGO:0042982130.091
renal system developmentGO:00720012250.090
canonical wnt signaling pathway involved in neural crest cell differentiationGO:004433510.090
regulation of adaptive immune responseGO:0002819900.089
epithelial tube morphogenesisGO:00605623030.089
glycosaminoglycan biosynthetic processGO:0006024150.089
visual perceptionGO:0007601520.089
regulation of protein serine threonine kinase activityGO:00719001570.089
nucleoside phosphate catabolic processGO:19012922220.089
intestinal absorptionGO:0050892130.088
apoptotic cell clearanceGO:0043277170.088
cardiac chamber developmentGO:00032051080.088
lipid storageGO:0019915360.088
glucan metabolic processGO:0044042320.088
planar cell polarity pathway involved in outflow tract morphogenesisGO:006134720.088
glycogen metabolic processGO:0005977320.087
protein modification by small protein conjugationGO:00324461870.087
negative regulation of cholesterol effluxGO:009037040.087
regulation of system processGO:00440572000.087
purine ribonucleoside monophosphate metabolic processGO:0009167800.087
apoptotic signaling pathwayGO:00971903060.087
regulation of lymphocyte proliferationGO:00506701170.086
transforming growth factor beta receptor signaling pathwayGO:0007179710.086
stem cell maintenanceGO:00198271300.085
regulation of protein localizationGO:00328802310.085
external genitalia morphogenesisGO:003526110.085
peptide metabolic processGO:0006518460.085
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101610.085
appendage morphogenesisGO:00351071490.084
positive regulation of lymphocyte activationGO:00512511400.084
microtubule based processGO:00070172360.083
negative regulation of fat cell differentiationGO:0045599360.083
oocyte developmentGO:0048599330.083
erbb signaling pathwayGO:0038127320.083
response to insulinGO:00328681000.083
female gamete generationGO:0007292740.083
cellular response to molecule of bacterial originGO:0071219830.082
negative regulation of amyloid precursor protein biosynthetic processGO:004298520.082
negative regulation of protein processingGO:0010955790.081
response to lipopolysaccharideGO:00324961280.081
ribonucleoside triphosphate catabolic processGO:00092031990.081
immune response regulating signaling pathwayGO:00027641250.080
regulation of leukocyte proliferationGO:00706631210.080
locomotor rhythmGO:004547580.080
regulation of mesenchymal cell proliferationGO:0010464370.080
regulation of fatty acid biosynthetic processGO:0042304120.080
cation homeostasisGO:00550802120.080
regulation of ion transportGO:00432692150.080
positive regulation of glucose metabolic processGO:0010907210.080
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.079
developmental maturationGO:00217001930.079
negative regulation of protein maturationGO:1903318790.079
canonical wnt signaling pathway involved in heart developmentGO:006131630.079
positive regulation of endocytosisGO:0045807420.079
cholesterol importGO:007050820.079
telencephalon developmentGO:00215371860.079
photoreceptor cell maintenanceGO:0045494190.078
positive regulation of ossificationGO:0045778470.078
peptidyl lysine modificationGO:0018205770.078
regulation of anion transportGO:0044070270.078
canonical wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferationGO:006132420.078
protein targetingGO:00066051430.078
ventricular system developmentGO:0021591270.078
fatty acid transmembrane transportGO:190200110.078
regulation of neuron differentiationGO:00456642810.077
nucleoside monophosphate catabolic processGO:0009125590.077
lung alveolus developmentGO:0048286450.077
learningGO:0007612980.077
organic acid transportGO:00158491010.077

Npc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.991
Human
lipid metabolism disorderDOID:314600.934
inherited metabolic disorderDOID:65500.934
Human
central nervous system diseaseDOID:33100.184
disease of anatomical entityDOID:700.184
Human
nervous system diseaseDOID:86300.184
immune system diseaseDOID:291400.176
Human
lymphatic system diseaseDOID:7500.176
Human
acquired metabolic diseaseDOID:006015800.107
neurodegenerative diseaseDOID:128900.078