IMP: Integrative Multi-species Prediction

Mus musculus

234 known processes

Smad2

MAD homolog 2 (Drosophila)

(Aliases: Madh2,Madr2)

Entrez: 17126
Ensembl: ENSMUSG00000024563
UniProtKB: Q62432

Process Predictions
Disease Predictions

Smad2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
metanephric mesenchyme morphogenesis	GO:0072133	4	0.991	Mouse
cell proliferation involved in heart valve morphogenesis	GO:0003249	1	0.975	Mouse
regulation of smad protein import into nucleus	GO:0060390	3	0.971	Mouse
gastrulation	GO:0007369	116	0.949
regionalization	GO:0003002	337	0.947
germline cell cycle switching mitotic to meiotic cell cycle	GO:0051729	1	0.944	Worm
digestive tract development	GO:0048565	190	0.911
digestive system development	GO:0055123	200	0.907
nephrogenic mesenchyme development	GO:0072076	3	0.906	Mouse
germ line stem cell division	GO:0042078	2	0.870
response to growth factor	GO:0070848	198	0.850
negative regulation of peptidyl threonine phosphorylation	GO:0010801	6	0.846	Mouse
embryonic skeletal system development	GO:0048706	120	0.836
regulation of neuron differentiation	GO:0045664	281	0.830
nephrogenic mesenchyme morphogenesis	GO:0072134	2	0.791	Mouse
erythrocyte differentiation	GO:0030218	88	0.786	Mouse
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.784
cellular response to growth factor stimulus	GO:0071363	197	0.783
kidney mesenchyme morphogenesis	GO:0072131	4	0.772	Mouse
positive regulation of neuron differentiation	GO:0045666	141	0.771
connective tissue development	GO:0061448	179	0.750	Mouse
amine metabolic process	GO:0009308	45	0.733
digestive tract morphogenesis	GO:0048546	147	0.724
skeletal system development	GO:0001501	356	0.713
osteoblast fate commitment	GO:0002051	4	0.713	Mouse
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	1	0.690
positive regulation of protein modification process	GO:0031401	299	0.671	Mouse
endothelial cell activation	GO:0042118	1	0.665	Mouse
positive regulation of protein phosphorylation	GO:0001934	242	0.664	Mouse
cell fate commitment	GO:0045165	210	0.663
regulation of mapk cascade	GO:0043408	248	0.655
central nervous system neuron differentiation	GO:0021953	162	0.649
urogenital system development	GO:0001655	261	0.637
positive regulation of osteoblast differentiation	GO:0045669	34	0.610	Mouse
positive regulation of nervous system development	GO:0051962	221	0.582
homeostasis of number of cells	GO:0048872	210	0.567	Mouse
brainstem development	GO:0003360	3	0.565	Mouse
dendrite development	GO:0016358	115	0.560
regulation of osteoblast differentiation	GO:0045667	67	0.551	Mouse
cartilage development	GO:0051216	140	0.539	Mouse
blood vessel morphogenesis	GO:0048514	285	0.534	Mouse
protein localization to nucleus	GO:0034504	121	0.521	Mouse
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO:1902043	13	0.515
pathway restricted smad protein phosphorylation	GO:0060389	10	0.514	Mouse
protein import into nucleus	GO:0006606	95	0.514	Mouse
cell cycle switching mitotic to meiotic cell cycle	GO:0051728	1	0.513	Worm
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus	GO:1901522	7	0.508	Mouse
regulation of cell cycle	GO:0051726	281	0.494	Worm
mapk cascade	GO:0000165	281	0.478	Mouse
regulation of neuron projection development	GO:0010975	169	0.473
epithelial tube morphogenesis	GO:0060562	303	0.462	Mouse
germ cell development	GO:0007281	185	0.462	Zebrafish Mouse
myeloid cell differentiation	GO:0030099	233	0.450	Mouse
negative regulation of cell proliferation	GO:0008285	296	0.444	Mouse
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.439
cell proliferation involved in heart valve development	GO:2000793	2	0.429	Mouse
regulation of cell projection organization	GO:0031344	206	0.425
oocyte axis specification	GO:0007309	2	0.420
positive regulation of cell development	GO:0010720	237	0.415
regulation of ossification	GO:0030278	112	0.404	Mouse
stem cell differentiation	GO:0048863	268	0.399
cell cycle switching	GO:0060184	1	0.399	Worm
spermatogenesis	GO:0007283	284	0.395
mesendoderm development	GO:0048382	3	0.395
positive regulation of nucleocytoplasmic transport	GO:0046824	30	0.391	Mouse
cellular amine metabolic process	GO:0044106	44	0.390
stem cell division	GO:0017145	30	0.385
regulation of transforming growth factor beta2 production	GO:0032909	2	0.380
negative regulation of osteoblast proliferation	GO:0033689	4	0.380	Mouse
dna metabolic process	GO:0006259	303	0.374
negative regulation of phosphorylation	GO:0042326	166	0.373	Mouse
regulation of transferase activity	GO:0051338	263	0.363
smad protein complex assembly	GO:0007183	1	0.361	Human
hindbrain development	GO:0030902	128	0.358	Mouse
gastrulation with mouth forming second	GO:0001702	29	0.358	Mouse
regulation of cell proliferation involved in heart valve morphogenesis	GO:0003250	1	0.358	Mouse
axonogenesis	GO:0007409	274	0.357	Mouse
cellular response to dna damage stimulus	GO:0006974	207	0.355
epithelial cell proliferation	GO:0050673	174	0.353	Mouse
embryonic skeletal system morphogenesis	GO:0048704	91	0.351
positive regulation of cellular protein catabolic process	GO:1903364	34	0.349
regulation of protein import into nucleus	GO:0042306	52	0.343	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.343
camera type eye development	GO:0043010	266	0.339	Mouse
smad protein signal transduction	GO:0060395	21	0.328
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.325
developmental maturation	GO:0021700	193	0.324
oocyte construction	GO:0007308	2	0.322
positive regulation of protein ubiquitination	GO:0031398	27	0.320
positive regulation of protein localization to nucleus	GO:1900182	30	0.320	Mouse
ossification	GO:0001503	216	0.317	Mouse
respiratory system development	GO:0060541	190	0.316
cell cell junction organization	GO:0045216	72	0.308
regulation of myeloid cell differentiation	GO:0045637	96	0.307
regulation of protein kinase activity	GO:0045859	232	0.303
mesenchymal cell differentiation	GO:0048762	107	0.301
developmental cell growth	GO:0048588	84	0.298
lens development in camera type eye	GO:0002088	62	0.296	Mouse
epithelial to mesenchymal transition involved in endocardial cushion formation	GO:0003198	10	0.296	Mouse
determination of left right symmetry	GO:0007368	80	0.295	Human Mouse
genetic imprinting	GO:0071514	27	0.294
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	43	0.287	Human Mouse
establishment of protein localization to organelle	GO:0072594	118	0.287	Mouse
regulation of apoptotic signaling pathway	GO:2001233	197	0.286
female gamete generation	GO:0007292	74	0.285	Zebrafish
skeletal system morphogenesis	GO:0048705	203	0.281
mesenchyme development	GO:0060485	152	0.279
modification dependent macromolecule catabolic process	GO:0043632	133	0.277
formation of radial glial scaffolds	GO:0021943	4	0.275
ameboidal type cell migration	GO:0001667	128	0.273
single organism nuclear import	GO:1902593	95	0.273	Mouse
cell fate specification	GO:0001708	72	0.270
nephron tubule morphogenesis	GO:0072078	68	0.269	Mouse
tube formation	GO:0035148	140	0.268
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.268	Human Mouse
positive regulation of kinase activity	GO:0033674	155	0.267
morphogenesis of a branching epithelium	GO:0061138	193	0.267	Mouse
cell aging	GO:0007569	35	0.266
cell fate determination	GO:0001709	32	0.264
positive regulation of smad protein import into nucleus	GO:0060391	2	0.260	Mouse
embryonic epithelial tube formation	GO:0001838	130	0.257
cytoplasmic transport	GO:0016482	234	0.257	Mouse
bone development	GO:0060348	120	0.250	Mouse
peptidyl amino acid modification	GO:0018193	336	0.249	Mouse
respiratory tube development	GO:0030323	167	0.249
mesoderm development	GO:0007498	100	0.248
wnt signaling pathway	GO:0016055	188	0.245
neural tube closure	GO:0001843	90	0.241
regulation of peptidyl threonine phosphorylation	GO:0010799	12	0.241	Mouse
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.239
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.239
response to bmp	GO:0071772	14	0.236	Mouse
cardiac muscle tissue morphogenesis	GO:0055008	44	0.236	Mouse
palate development	GO:0060021	76	0.235
asymmetric neuroblast division	GO:0055059	1	0.233
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.232
developmental growth involved in morphogenesis	GO:0060560	138	0.231
molting cycle	GO:0042303	90	0.228	Mouse
negative regulation of epithelial cell proliferation	GO:0050680	64	0.227
asymmetric stem cell division	GO:0098722	3	0.226
synapse organization	GO:0050808	125	0.224
gonad development	GO:0008406	141	0.223
positive regulation of mapk cascade	GO:0043410	170	0.221
organ growth	GO:0035265	117	0.221
regulation of pathway restricted smad protein phosphorylation	GO:0060393	6	0.221	Mouse
transforming growth factor beta2 production	GO:0032906	2	0.220
protein localization to organelle	GO:0033365	185	0.218	Mouse
positive regulation of ossification	GO:0045778	47	0.214	Mouse
phagocytosis	GO:0006909	66	0.212
morphogenesis of embryonic epithelium	GO:0016331	159	0.211
pigmentation	GO:0043473	71	0.210
establishment or maintenance of cell polarity	GO:0007163	86	0.209
carbon catabolite activation of transcription	GO:0045991	4	0.209
organonitrogen compound biosynthetic process	GO:1901566	192	0.209
establishment or maintenance of apical basal cell polarity	GO:0035088	21	0.206
epidermis development	GO:0008544	187	0.205	Mouse
pole plasm assembly	GO:0007315	2	0.204
regulation of cellular amino acid metabolic process	GO:0006521	5	0.204
heart field specification	GO:0003128	6	0.204
chemotaxis	GO:0006935	247	0.199	Mouse
stem cell development	GO:0048864	219	0.198
epithelial tube formation	GO:0072175	130	0.196
embryonic organ morphogenesis	GO:0048562	276	0.194
negative regulation of neuron differentiation	GO:0045665	101	0.194
renal tubule development	GO:0061326	87	0.191	Mouse
neural tube formation	GO:0001841	108	0.190
peptidyl tyrosine phosphorylation	GO:0018108	143	0.190
canonical wnt signaling pathway	GO:0060070	130	0.190
appendage development	GO:0048736	166	0.189
regulation of protein localization	GO:0032880	231	0.185	Mouse
regulation of chondrocyte differentiation	GO:0032330	33	0.182	Mouse
ribose phosphate biosynthetic process	GO:0046390	59	0.181
neuron projection extension	GO:1990138	64	0.180
regulation of cytoplasmic transport	GO:1903649	112	0.178	Mouse
vesicle localization	GO:0051648	86	0.177
negative regulation of intracellular signal transduction	GO:1902532	167	0.175
regulation of cellular amine metabolic process	GO:0033238	20	0.174
mitotic cell cycle process	GO:1903047	159	0.171
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	16	0.170
camp biosynthetic process	GO:0006171	31	0.169
cell fate commitment involved in formation of primary germ layer	GO:0060795	26	0.169	Mouse
actin cytoskeleton organization	GO:0030036	220	0.168
kidney development	GO:0001822	213	0.168
myeloid leukocyte differentiation	GO:0002573	119	0.166
protein import	GO:0017038	101	0.165	Mouse
regulation of nucleotide biosynthetic process	GO:0030808	34	0.164
regulation of protein transport	GO:0051223	163	0.164	Mouse
protein autophosphorylation	GO:0046777	61	0.163
jnk cascade	GO:0007254	72	0.161
regulation of protein serine threonine kinase activity	GO:0071900	157	0.161
schwann cell proliferation	GO:0014010	2	0.160
angiogenesis	GO:0001525	201	0.159
regulation of organelle organization	GO:0033043	289	0.159
male gamete generation	GO:0048232	285	0.158
regulation of bmp signaling pathway	GO:0030510	60	0.157	Human Mouse
positive regulation of cytoplasmic transport	GO:1903651	40	0.157	Mouse
positive regulation of protein import into nucleus	GO:0042307	26	0.157	Mouse
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	43	0.156	Human Mouse
positive regulation of protein modification by small protein conjugation or removal	GO:1903322	30	0.155
cyclic nucleotide biosynthetic process	GO:0009190	44	0.154
metencephalon development	GO:0022037	89	0.154
response to transforming growth factor beta	GO:0071559	88	0.154
activation of adenylate cyclase activity	GO:0007190	4	0.153
nephron epithelium morphogenesis	GO:0072088	68	0.153	Mouse
endochondral bone morphogenesis	GO:0060350	50	0.153
sperm ejaculation	GO:0042713	1	0.152
positive regulation of intracellular protein transport	GO:0090316	42	0.149	Mouse
cell growth	GO:0016049	130	0.149
cellular protein catabolic process	GO:0044257	155	0.149
canonical wnt signaling pathway involved in heart development	GO:0061316	3	0.149
oocyte anterior posterior axis specification	GO:0007314	2	0.149
neural tube development	GO:0021915	160	0.148
fat cell differentiation	GO:0045444	160	0.148
branching morphogenesis of an epithelial tube	GO:0048754	159	0.147	Mouse
positive regulation of glial cell proliferation	GO:0060252	4	0.147
segmentation	GO:0035282	93	0.145	Mouse
regulation of cell motility	GO:2000145	236	0.145
heart valve morphogenesis	GO:0003179	21	0.144	Mouse
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.144
positive regulation of cell motility	GO:2000147	116	0.143
hormone secretion	GO:0046879	128	0.141
cyclic nucleotide metabolic process	GO:0009187	59	0.141
central nervous system neuron development	GO:0021954	67	0.140
oogenesis	GO:0048477	56	0.140	Zebrafish
ribonucleotide biosynthetic process	GO:0009260	59	0.140
myeloid cell homeostasis	GO:0002262	114	0.140	Mouse
extrinsic apoptotic signaling pathway	GO:0097191	126	0.140
regulation of cell migration	GO:0030334	219	0.139
epithelial to mesenchymal transition	GO:0001837	47	0.138
protein modification by small protein conjugation or removal	GO:0070647	207	0.138
cardiac chamber morphogenesis	GO:0003206	93	0.137	Mouse
retina vasculature development in camera type eye	GO:0061298	17	0.137
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.136
neural precursor cell proliferation	GO:0061351	121	0.135
skin development	GO:0043588	220	0.135	Mouse
chondrocyte differentiation	GO:0002062	72	0.135	Mouse
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	56	0.135
response to monosaccharide	GO:0034284	67	0.133
regulation of protein stability	GO:0031647	52	0.131
regulation of mitotic cell cycle	GO:0007346	126	0.129	Worm
regulation of canonical wnt signaling pathway	GO:0060828	82	0.128
negative regulation of bmp signaling pathway	GO:0030514	35	0.128	Mouse
neuron apoptotic process	GO:0051402	142	0.128
engulfment of apoptotic cell	GO:0043652	3	0.128
morphogenesis of a branching structure	GO:0001763	203	0.128	Mouse
negative regulation of cyclin dependent protein serine threonine kinase activity	GO:0045736	9	0.127
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.127
regulation of defense response	GO:0031347	233	0.127	Mouse
regulation of secretion	GO:0051046	274	0.126
purine ribonucleotide biosynthetic process	GO:0009152	59	0.126
nucleocytoplasmic transport	GO:0006913	139	0.126	Mouse
regulation of erythrocyte differentiation	GO:0045646	23	0.125
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.125
regulation of cellular protein catabolic process	GO:1903362	61	0.125
positive regulation of apoptotic process	GO:0043065	217	0.125
ubiquitin dependent protein catabolic process	GO:0006511	129	0.124
carbohydrate derivative biosynthetic process	GO:1901137	183	0.123
regulation of system process	GO:0044057	200	0.123	Mouse
regulation of actin cytoskeleton organization	GO:0032956	84	0.122
foregut morphogenesis	GO:0007440	12	0.122
regulation of cellular catabolic process	GO:0031329	242	0.121
mesoderm formation	GO:0001707	62	0.119
embryonic heart tube morphogenesis	GO:0003143	51	0.118	Mouse
regulation of intracellular transport	GO:0032386	159	0.118	Mouse
formation of anatomical boundary	GO:0048859	6	0.117	Mouse
mesenchymal cell development	GO:0014031	93	0.116
mesenchyme morphogenesis	GO:0072132	32	0.116
regulation of cellular component size	GO:0032535	121	0.114
regulation of cellular component biogenesis	GO:0044087	181	0.114
bmp signaling pathway	GO:0030509	93	0.113	Human Mouse
regulation of wnt signaling pathway	GO:0030111	123	0.113
ribose phosphate metabolic process	GO:0019693	291	0.113
regulation of muscle tissue development	GO:1901861	97	0.112	Mouse
cellular macromolecule catabolic process	GO:0044265	206	0.112
protein processing	GO:0016485	163	0.111
negative regulation of protein serine threonine kinase activity	GO:0071901	49	0.111
regulation of synapse assembly	GO:0051963	29	0.111
nuclear import	GO:0051170	95	0.110	Mouse
mesoderm morphogenesis	GO:0048332	64	0.110
apoptotic signaling pathway	GO:0097190	306	0.110
ventricular septum development	GO:0003281	42	0.110	Mouse
positive regulation of transcription by galactose	GO:0000411	1	0.108
neuroblast division	GO:0055057	10	0.107
formation of primary germ layer	GO:0001704	77	0.107
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.107	Human Mouse
wound healing	GO:0042060	157	0.107	Mouse
cell cycle arrest	GO:0007050	37	0.106
ubiquitin dependent smad protein catabolic process	GO:0030579	2	0.106
cell division	GO:0051301	120	0.106
positive regulation of transferase activity	GO:0051347	167	0.106
protein targeting	GO:0006605	143	0.106	Mouse
positive regulation of programmed cell death	GO:0043068	218	0.106
regulation of epithelial cell proliferation	GO:0050678	141	0.105	Mouse
positive regulation of protein kinase activity	GO:0045860	144	0.103
amide transport	GO:0042886	138	0.103
odontogenesis	GO:0042476	78	0.103
regulation of t cell activation	GO:0050863	170	0.103
regulation of cytoskeleton organization	GO:0051493	122	0.103
ventricular septum morphogenesis	GO:0060412	27	0.102	Mouse
modification dependent protein catabolic process	GO:0019941	133	0.101
purine nucleotide biosynthetic process	GO:0006164	65	0.101
intracellular protein transport	GO:0006886	204	0.101	Mouse
regulation of cell adhesion	GO:0030155	154	0.100	Mouse
cardiac endothelial cell differentiation	GO:0003348	4	0.100	Mouse
stem cell proliferation	GO:0072089	117	0.099
branching involved in ureteric bud morphogenesis	GO:0001658	56	0.098	Mouse
methylation	GO:0032259	134	0.097
inner ear receptor cell differentiation	GO:0060113	61	0.096
response to organic cyclic compound	GO:0014070	198	0.095	Human Mouse
ribonucleotide metabolic process	GO:0009259	291	0.095
immune response activating signal transduction	GO:0002757	116	0.095
regulation of intracellular protein transport	GO:0033157	82	0.095	Mouse
neural crest cell differentiation	GO:0014033	54	0.095	Mouse
cell maturation	GO:0048469	127	0.093
regulation of cellular ketone metabolic process	GO:0010565	66	0.093
nitrogen compound transport	GO:0071705	271	0.093
positive regulation of cell proliferation involved in heart valve morphogenesis	GO:0003251	1	0.093	Mouse
mesodermal cell fate commitment	GO:0001710	17	0.093	Mouse
regulation of protein catabolic process	GO:0042176	108	0.092
dna endoreduplication	GO:0042023	4	0.090
cardiac muscle tissue development	GO:0048738	130	0.090	Mouse
positive regulation of myeloid cell differentiation	GO:0045639	43	0.089
camp metabolic process	GO:0046058	40	0.088
spermatid differentiation	GO:0048515	115	0.087
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.086
purine containing compound biosynthetic process	GO:0072522	70	0.086
negative regulation of growth	GO:0045926	99	0.086
regulation of proteasomal protein catabolic process	GO:0061136	46	0.086
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.086
positive regulation of cell death	GO:0010942	224	0.084
cardiocyte differentiation	GO:0035051	87	0.084	Mouse
nucleoside metabolic process	GO:0009116	246	0.084
renal system development	GO:0072001	225	0.084
biomineral tissue development	GO:0031214	64	0.084
regulation of biomineral tissue development	GO:0070167	33	0.084
endocytosis	GO:0006897	168	0.084
activin receptor signaling pathway	GO:0032924	18	0.083	Human
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.083
bone morphogenesis	GO:0060349	78	0.082
regulation of actin filament based process	GO:0032970	99	0.082
negative regulation of defense response	GO:0031348	77	0.082	Mouse
regulation of anatomical structure size	GO:0090066	178	0.082
activation of immune response	GO:0002253	138	0.082
positive regulation of cellular amine metabolic process	GO:0033240	5	0.082
regulation of nucleocytoplasmic transport	GO:0046822	73	0.081	Mouse
nucleoside phosphate metabolic process	GO:0006753	338	0.081
embryonic heart tube development	GO:0035050	65	0.081	Mouse
macroautophagy	GO:0016236	21	0.080
regulation of cellular response to stress	GO:0080135	159	0.080
mesonephric tubule morphogenesis	GO:0072171	63	0.079	Mouse
ureteric bud development	GO:0001657	94	0.078
cellular ketone metabolic process	GO:0042180	84	0.078
negative regulation of nervous system development	GO:0051961	156	0.078
hair follicle development	GO:0001942	85	0.077	Mouse
regulation of transcription by galactose	GO:0000409	1	0.077
organelle localization	GO:0051640	179	0.077
rna localization	GO:0006403	23	0.077
ras protein signal transduction	GO:0007265	77	0.076
regulation of secretion by cell	GO:1903530	249	0.076
response to radiation	GO:0009314	165	0.076
heart morphogenesis	GO:0003007	178	0.076	Mouse
regulation of hydrolase activity	GO:0051336	246	0.075
kidney morphogenesis	GO:0060993	83	0.075	Mouse
negative regulation of phosphate metabolic process	GO:0045936	184	0.075	Mouse
lens morphogenesis in camera type eye	GO:0002089	24	0.074
positive regulation of neuron projection development	GO:0010976	79	0.074
fibroblast migration	GO:0010761	21	0.074
striated muscle tissue development	GO:0014706	293	0.074	Mouse
lipid localization	GO:0010876	126	0.073
regulation of vasculature development	GO:1901342	88	0.073
cellular response to lipid	GO:0071396	145	0.073
peptide hormone secretion	GO:0030072	109	0.073
determination of heart left right asymmetry	GO:0061371	48	0.073	Mouse
synaptic transmission	GO:0007268	329	0.073
positive regulation of transforming growth factor beta receptor signaling pathway	GO:0030511	12	0.073
regulation of epithelial to mesenchymal transition	GO:0010717	22	0.073
negative regulation of phosphorus metabolic process	GO:0010563	184	0.072	Mouse
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	31	0.072
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.072
nephron tubule development	GO:0072080	84	0.072	Mouse
blastoderm segmentation	GO:0007350	13	0.072
protein catabolic process	GO:0030163	221	0.072
lymphocyte homeostasis	GO:0002260	64	0.071
cellular response to abiotic stimulus	GO:0071214	56	0.071
pancreas development	GO:0031016	57	0.071
regulation of binding	GO:0051098	111	0.071
central nervous system maturation	GO:0021626	6	0.071
regulation of neuron apoptotic process	GO:0043523	122	0.071
response to drug	GO:0042493	75	0.071
ureteric bud morphogenesis	GO:0060675	62	0.070	Mouse
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.069
regulation of kinase activity	GO:0043549	249	0.069
gland development	GO:0048732	330	0.069	Mouse
negative regulation of wound healing	GO:0061045	14	0.068	Mouse
maintenance of location	GO:0051235	89	0.068
positive regulation of protein transport	GO:0051222	93	0.068	Mouse
mechanoreceptor differentiation	GO:0042490	67	0.068
positive regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process	GO:2000060	8	0.068
peptidyl threonine phosphorylation	GO:0018107	31	0.068	Mouse
positive regulation of cell migration	GO:0030335	109	0.068
circulatory system process	GO:0003013	197	0.067	Mouse
embryonic hindlimb morphogenesis	GO:0035116	32	0.067
nucleobase containing small molecule metabolic process	GO:0055086	352	0.067
negative regulation of protein phosphorylation	GO:0001933	126	0.067	Mouse
somitogenesis	GO:0001756	69	0.067	Mouse
regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway	GO:2001267	4	0.067
retina development in camera type eye	GO:0060041	119	0.065
mammary gland morphogenesis	GO:0060443	54	0.065
cyclic purine nucleotide metabolic process	GO:0052652	43	0.065
antigen receptor mediated signaling pathway	GO:0050851	64	0.065
positive regulation of camp metabolic process	GO:0030816	19	0.064
mammary gland epithelium development	GO:0061180	65	0.064
negative regulation of cell development	GO:0010721	169	0.063
regulation of nucleotide metabolic process	GO:0006140	169	0.063
embryonic skeletal joint development	GO:0072498	13	0.063
regulation of purine nucleotide biosynthetic process	GO:1900371	34	0.063
cytokine biosynthetic process	GO:0042089	68	0.063
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.063
negative regulation of cell cycle	GO:0045786	123	0.063	Worm
blood circulation	GO:0008015	195	0.063	Mouse
regulation of protein localization to nucleus	GO:1900180	60	0.062	Mouse
lung morphogenesis	GO:0060425	50	0.062
primary neural tube formation	GO:0014020	95	0.062
locomotory behavior	GO:0007626	195	0.062
regulation of fat cell differentiation	GO:0045598	81	0.062
peptide secretion	GO:0002790	114	0.062
anatomical structure homeostasis	GO:0060249	145	0.061
positive regulation of cell projection organization	GO:0031346	95	0.061
mesodermal cell differentiation	GO:0048333	22	0.061	Mouse
smad protein import into nucleus	GO:0007184	6	0.060	Mouse
negative regulation of protein modification process	GO:0031400	163	0.060	Mouse
nephron morphogenesis	GO:0072028	69	0.060	Mouse
carbon catabolite regulation of transcription	GO:0045990	4	0.060
kidney epithelium development	GO:0072073	121	0.060
peptidyl serine phosphorylation	GO:0018105	74	0.060	Mouse
nucleoside phosphate biosynthetic process	GO:1901293	79	0.060
oocyte differentiation	GO:0009994	35	0.060	Zebrafish
endodermal cell fate commitment	GO:0001711	12	0.060
regulation of camp biosynthetic process	GO:0030817	25	0.059
mesonephric epithelium development	GO:0072163	94	0.059
microtubule severing	GO:0051013	5	0.059
b cell homeostasis	GO:0001782	34	0.059
negative regulation of dna replication	GO:0008156	4	0.059
nuclear transport	GO:0051169	139	0.059	Mouse
cardiac chamber development	GO:0003205	108	0.059	Mouse
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.058
synaptic growth at neuromuscular junction	GO:0051124	6	0.058
regulation of homeostatic process	GO:0032844	182	0.058
regulation of transcription factor import into nucleus	GO:0042990	24	0.058
embryonic hemopoiesis	GO:0035162	23	0.057
regulation of heart contraction	GO:0008016	77	0.057	Mouse
limb development	GO:0060173	166	0.057
cardiac ventricle morphogenesis	GO:0003208	50	0.057	Mouse
photoreceptor cell morphogenesis	GO:0008594	3	0.056
immune response regulating signaling pathway	GO:0002764	125	0.056
regulation of cyclic nucleotide metabolic process	GO:0030799	40	0.055
ribonucleoside metabolic process	GO:0009119	245	0.055
establishment or maintenance of bipolar cell polarity	GO:0061245	21	0.055
membrane organization	GO:0061024	245	0.055
adult locomotory behavior	GO:0008344	91	0.055
trachea formation	GO:0060440	3	0.054
cell junction assembly	GO:0034329	52	0.054
regulation of tube size	GO:0035150	57	0.054
establishment of organelle localization	GO:0051656	122	0.054
regulation of body fluid levels	GO:0050878	162	0.054
positive regulation of nucleotide metabolic process	GO:0045981	114	0.053
positive regulation of intracellular transport	GO:0032388	70	0.053	Mouse
positive regulation of erythrocyte differentiation	GO:0045648	11	0.053
regulation of map kinase activity	GO:0043405	120	0.053
negative regulation of peptidyl serine phosphorylation	GO:0033137	10	0.053	Mouse
peptidyl threonine modification	GO:0018210	31	0.053	Mouse
organophosphate biosynthetic process	GO:0090407	122	0.052
trachea development	GO:0060438	18	0.052
cardiac muscle cell proliferation	GO:0060038	31	0.052	Mouse
negative regulation of cell motility	GO:2000146	61	0.052
cell adhesion	GO:0007155	329	0.052	Mouse
regulation of cell growth	GO:0001558	91	0.052
neuron maturation	GO:0042551	29	0.052
regulation of stem cell differentiation	GO:2000736	50	0.052
regulation of muscle contraction	GO:0006937	49	0.051	Mouse
regulation of hormone levels	GO:0010817	211	0.051
regulation of establishment of protein localization	GO:0070201	181	0.051	Mouse
microtubule based process	GO:0007017	236	0.051
hindlimb morphogenesis	GO:0035137	42	0.051
t cell differentiation	GO:0030217	174	0.051
embryonic digit morphogenesis	GO:0042733	56	0.051
centromeric sister chromatid cohesion	GO:0070601	3	0.051

Smad2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.718
cancer	DOID:162	0.659
large intestine cancer	DOID:5672	0.160
colon cancer	DOID:219	0.160
gastrointestinal system cancer	DOID:3119	0.160
intestinal cancer	DOID:10155	0.160
organ system cancer	DOID:0050686	0.160
colorectal cancer	DOID:9256	0.160

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