IMP: Integrative Multi-species Prediction

Mus musculus

89 known processes

Mcl1

myeloid cell leukemia sequence 1

(Aliases: AW556805,Mcl-1)

Entrez: 17210
Ensembl: ENSMUSG00000038612
UniProtKB: P97287

Process Predictions
Disease Predictions

Mcl1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
positive regulation of mitochondrial membrane permeability involved in apoptotic process	GO:1902110	11	0.996	Mouse
release of cytochrome c from mitochondria	GO:0001836	23	0.964	Mouse
negative regulation of cell proliferation	GO:0008285	296	0.926	Mouse
positive regulation of mitochondrion organization	GO:0010822	17	0.926	Worm
positive regulation of cell death	GO:0010942	224	0.923
regulation of mitochondrion organization	GO:0010821	27	0.915	Worm
positive regulation of release of cytochrome c from mitochondria	GO:0090200	5	0.914
homeostasis of number of cells	GO:0048872	210	0.890	Mouse
reactive oxygen species metabolic process	GO:0072593	84	0.890	Mouse
cellular response to dna damage stimulus	GO:0006974	207	0.876
lymphocyte homeostasis	GO:0002260	64	0.854	Mouse
positive regulation of mitochondrial membrane permeability	GO:0035794	12	0.844	Mouse
positive regulation of programmed cell death	GO:0043068	218	0.843
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	57	0.839
amine metabolic process	GO:0009308	45	0.827
negative regulation of cellular amine metabolic process	GO:0033239	1	0.817
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	GO:1901030	6	0.806
mitochondrial membrane organization	GO:0007006	26	0.803	Mouse
apoptotic mitochondrial changes	GO:0008637	48	0.801
response to organic cyclic compound	GO:0014070	198	0.800	Mouse
negative regulation of fibroblast proliferation	GO:0048147	14	0.799	Mouse
response to ionizing radiation	GO:0010212	42	0.794	Mouse
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.777	Zebrafish Mouse
immune effector process	GO:0002252	321	0.764
response to organonitrogen compound	GO:0010243	246	0.761	Mouse
intrinsic apoptotic signaling pathway by p53 class mediator	GO:0072332	35	0.758	Mouse
mitochondrial transport	GO:0006839	36	0.758	Mouse
positive regulation of cysteine type endopeptidase activity	GO:2001056	39	0.756	Mouse
leukocyte differentiation	GO:0002521	342	0.744	Mouse
positive regulation of endopeptidase activity	GO:0010950	43	0.734	Mouse
positive regulation of apoptotic process	GO:0043065	217	0.702
regulation of apoptotic signaling pathway	GO:2001233	197	0.695
cellular response to organonitrogen compound	GO:0071417	145	0.687	Mouse
positive regulation of proteolysis	GO:0045862	85	0.681	Mouse
regulation of cellular ketone metabolic process	GO:0010565	66	0.681
activation of immune response	GO:0002253	138	0.671
extrinsic apoptotic signaling pathway	GO:0097191	126	0.670
t cell activation	GO:0042110	289	0.656	Mouse
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.655
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.653	Zebrafish Mouse
camera type eye development	GO:0043010	266	0.645	Mouse
regulation of endopeptidase activity	GO:0052548	89	0.639	Zebrafish Mouse
regulation of cellular amino acid metabolic process	GO:0006521	5	0.632
cellular macromolecule catabolic process	GO:0044265	206	0.630
regulation of mitochondrial membrane permeability involved in apoptotic process	GO:1902108	14	0.628	Mouse
positive regulation of protein oligomerization	GO:0032461	4	0.623
t cell differentiation in thymus	GO:0033077	77	0.611	Mouse
regulation of mitochondrial membrane permeability	GO:0046902	17	0.611	Mouse
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	36	0.594	Mouse
macromolecule catabolic process	GO:0009057	281	0.583
establishment of protein localization to organelle	GO:0072594	118	0.583	Mouse
t cell homeostasis	GO:0043029	35	0.581	Mouse
positive regulation of peptidase activity	GO:0010952	49	0.566	Mouse
intrinsic apoptotic signaling pathway	GO:0097193	132	0.563
protein localization to membrane	GO:0072657	108	0.563	Mouse
establishment of protein localization to membrane	GO:0090150	54	0.555	Mouse
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	GO:1900740	3	0.554
mitochondrion organization	GO:0007005	134	0.551
cellular response to glucose starvation	GO:0042149	5	0.547	Mouse
response to oxygen levels	GO:0070482	62	0.539	Mouse
mitochondrial outer membrane permeabilization	GO:0097345	10	0.534	Mouse
protein processing	GO:0016485	163	0.530	Zebrafish Mouse
protein maturation	GO:0051604	176	0.525	Zebrafish Mouse
activation of cysteine type endopeptidase activity	GO:0097202	27	0.519	Mouse
cellular response to starvation	GO:0009267	57	0.513	Mouse
t cell differentiation	GO:0030217	174	0.512	Mouse
immune response regulating signaling pathway	GO:0002764	125	0.503
blood vessel morphogenesis	GO:0048514	285	0.499	Mouse
regulation of cellular response to stress	GO:0080135	159	0.495
positive regulation of neuron apoptotic process	GO:0043525	25	0.495
establishment of protein localization to mitochondrion	GO:0072655	11	0.494	Mouse
response to hypoxia	GO:0001666	58	0.483	Mouse
extrinsic apoptotic signaling pathway via death domain receptors	GO:0008625	34	0.482	Mouse
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.475	Mouse
regulation of hydrolase activity	GO:0051336	246	0.450	Zebrafish Mouse Worm
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.449	Human Mouse
regulation of establishment of protein localization	GO:0070201	181	0.447
regulation of intracellular transport	GO:0032386	159	0.443	Mouse
response to dsrna	GO:0043331	30	0.442
response to oxidative stress	GO:0006979	123	0.436
positive regulation of neuron death	GO:1901216	28	0.435
protein insertion into mitochondrial membrane	GO:0051204	4	0.430	Mouse
defense response to other organism	GO:0098542	197	0.429
positive regulation of intrinsic apoptotic signaling pathway	GO:2001244	25	0.422
apoptotic signaling pathway	GO:0097190	306	0.419
cellular amino acid metabolic process	GO:0006520	103	0.413
protein catabolic process	GO:0030163	221	0.408
fibroblast proliferation	GO:0048144	35	0.392	Mouse
protein modification by small protein conjugation	GO:0032446	187	0.391
cell type specific apoptotic process	GO:0097285	268	0.390
lymphocyte differentiation	GO:0030098	242	0.384	Mouse
lymphocyte proliferation	GO:0046651	164	0.378	Mouse
immune response activating signal transduction	GO:0002757	116	0.364
cellular protein catabolic process	GO:0044257	155	0.359
positive regulation of protein modification process	GO:0031401	299	0.359	Mouse
myeloid cell differentiation	GO:0030099	233	0.357
interspecies interaction between organisms	GO:0044419	83	0.352	Mouse
gland development	GO:0048732	330	0.347	Mouse
nucleoside metabolic process	GO:0009116	246	0.334	Worm
defense response to virus	GO:0051607	68	0.331
myeloid leukocyte differentiation	GO:0002573	119	0.324
membrane organization	GO:0061024	245	0.322	Mouse Worm
regulation of leukocyte differentiation	GO:1902105	159	0.321
regulation of protein localization	GO:0032880	231	0.317	Mouse
cellular response to oxygen levels	GO:0071453	20	0.314	Mouse
response to radiation	GO:0009314	165	0.314	Mouse
leukocyte homeostasis	GO:0001776	79	0.313	Mouse
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO:1902043	13	0.307
negative regulation of protein metabolic process	GO:0051248	282	0.303	Zebrafish Mouse
neuron apoptotic process	GO:0051402	142	0.301
regulation of release of cytochrome c from mitochondria	GO:0090199	11	0.300
regulation of lymphocyte activation	GO:0051249	240	0.296
peptidyl lysine modification	GO:0018205	77	0.294
regulation of cellular amine metabolic process	GO:0033238	20	0.288
gene silencing by mirna	GO:0035195	10	0.281
regulation of inflammatory response	GO:0050727	147	0.277
cellular response to extracellular stimulus	GO:0031668	81	0.276	Mouse
regulation of fibroblast proliferation	GO:0048145	34	0.273	Mouse
regulation of neuron apoptotic process	GO:0043523	122	0.272
zymogen activation	GO:0031638	41	0.269	Mouse
response to peptide	GO:1901652	136	0.259
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.255
epidermis development	GO:0008544	187	0.252	Mouse
regulation of multi organism process	GO:0043900	111	0.249	Mouse
osteoclast differentiation	GO:0030316	62	0.247
regulation of membrane potential	GO:0042391	192	0.246	Mouse
cellular response to oxidative stress	GO:0034599	76	0.241
methylation	GO:0032259	134	0.240
cellular nitrogen compound catabolic process	GO:0044270	280	0.239	Worm
regulation of organelle organization	GO:0033043	289	0.238	Zebrafish Worm
glycosyl compound metabolic process	GO:1901657	246	0.235	Worm
positive regulation of organelle organization	GO:0010638	128	0.232	Worm
regulation of cytokine production	GO:0001817	266	0.229
positive regulation of hydrolase activity	GO:0051345	148	0.228	Mouse Worm
positive regulation of extrinsic apoptotic signaling pathway	GO:2001238	34	0.221	Mouse
single organism cell adhesion	GO:0098602	156	0.220	Mouse
nucleobase containing small molecule metabolic process	GO:0055086	352	0.219	Worm
regulation of peptidase activity	GO:0052547	96	0.215	Zebrafish Mouse
negative regulation of phosphorus metabolic process	GO:0010563	184	0.212	Mouse
striated muscle tissue development	GO:0014706	293	0.212	Mouse
multicellular organism growth	GO:0035264	161	0.211	Mouse
regulation of t cell activation	GO:0050863	170	0.207
response to x ray	GO:0010165	11	0.207
response to peptide hormone	GO:0043434	127	0.206
regulation of mitochondrial membrane potential	GO:0051881	17	0.206	Mouse
protein localization to organelle	GO:0033365	185	0.199	Mouse
positive regulation of leukocyte differentiation	GO:1902107	86	0.199
developmental maturation	GO:0021700	193	0.198	Mouse
regulation of organ morphogenesis	GO:2000027	144	0.197	Mouse
organic cyclic compound catabolic process	GO:1901361	295	0.196	Worm
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.195
stem cell maintenance	GO:0019827	130	0.193
cytokine production	GO:0001816	319	0.192
muscle tissue development	GO:0060537	308	0.188	Mouse
cellular amine metabolic process	GO:0044106	44	0.187
renal system development	GO:0072001	225	0.182	Mouse
angiogenesis	GO:0001525	201	0.178	Mouse
response to starvation	GO:0042594	65	0.177	Mouse
negative regulation of protein modification process	GO:0031400	163	0.175	Mouse
regulation of myeloid leukocyte differentiation	GO:0002761	58	0.175
nucleotide catabolic process	GO:0009166	217	0.174	Worm
protein ubiquitination	GO:0016567	171	0.174
striated muscle cell development	GO:0055002	125	0.172	Mouse
skin development	GO:0043588	220	0.169	Mouse
positive regulation of cell development	GO:0010720	237	0.167	Mouse
stem cell development	GO:0048864	219	0.167	Mouse
heterocycle catabolic process	GO:0046700	280	0.164	Worm
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	27	0.163	Mouse
negative regulation of membrane potential	GO:0045837	4	0.163
protein methylation	GO:0006479	81	0.159
modification dependent protein catabolic process	GO:0019941	133	0.158
protein modification by small protein conjugation or removal	GO:0070647	207	0.156
peptidyl amino acid modification	GO:0018193	336	0.155	Mouse
axonogenesis	GO:0007409	274	0.155	Mouse
protein oligomerization	GO:0051259	67	0.155	Mouse
regulation of myotube differentiation	GO:0010830	62	0.154	Mouse
regulation of neuron death	GO:1901214	134	0.153
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.153
innate immune response	GO:0045087	157	0.150
protein localization to nucleus	GO:0034504	121	0.148
regulation of myeloid cell differentiation	GO:0045637	96	0.147
regulation of developmental pigmentation	GO:0048070	14	0.143	Mouse
positive regulation of myeloid leukocyte differentiation	GO:0002763	26	0.143
negative regulation of phosphate metabolic process	GO:0045936	184	0.142	Mouse
response to light stimulus	GO:0009416	135	0.141	Mouse
regulation of cellular component biogenesis	GO:0044087	181	0.139
monosaccharide metabolic process	GO:0005996	106	0.139
cellular ketone metabolic process	GO:0042180	84	0.139
positive regulation of protein complex assembly	GO:0031334	45	0.136
respiratory tube development	GO:0030323	167	0.135
muscle cell development	GO:0055001	133	0.135	Mouse
protein acylation	GO:0043543	64	0.135
skeletal muscle organ development	GO:0060538	163	0.131	Mouse
regulation of proteolysis	GO:0030162	164	0.127	Zebrafish Mouse
morphogenesis of a branching epithelium	GO:0061138	193	0.125	Mouse
skeletal muscle fiber development	GO:0048741	58	0.124	Mouse
regulation of innate immune response	GO:0045088	91	0.124
stem cell differentiation	GO:0048863	268	0.124	Mouse
regulation of glucose metabolic process	GO:0010906	60	0.123
positive regulation of cellular component biogenesis	GO:0044089	94	0.122
organonitrogen compound catabolic process	GO:1901565	264	0.121	Worm
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.121	Worm
peptidyl serine modification	GO:0018209	83	0.121	Mouse
viral process	GO:0016032	41	0.119	Mouse
mammary gland epithelium development	GO:0061180	65	0.119	Mouse
digestive tract development	GO:0048565	190	0.118	Mouse
proteasomal protein catabolic process	GO:0010498	98	0.118
innate immune response activating signal transduction	GO:0002758	50	0.117
regulation of protein transport	GO:0051223	163	0.117
hemostasis	GO:0007599	78	0.117
erk1 and erk2 cascade	GO:0070371	77	0.116
macromolecule methylation	GO:0043414	120	0.114
negative regulation of cellular protein metabolic process	GO:0032269	247	0.112	Zebrafish Mouse
peptidyl tyrosine modification	GO:0018212	145	0.111
digestive system development	GO:0055123	200	0.109	Mouse
alpha beta t cell differentiation	GO:0046632	69	0.109	Mouse
adaptive immune response	GO:0002250	155	0.107
respiratory system development	GO:0060541	190	0.107
negative regulation of intracellular signal transduction	GO:1902532	167	0.107
fat cell differentiation	GO:0045444	160	0.107
carbohydrate metabolic process	GO:0005975	230	0.105
regulation of body fluid levels	GO:0050878	162	0.105
monosaccharide transport	GO:0015749	58	0.105
membrane lipid metabolic process	GO:0006643	53	0.104	Mouse
positive regulation of cytokine production	GO:0001819	174	0.102
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.102
positive regulation of myeloid cell differentiation	GO:0045639	43	0.101
purine ribonucleotide metabolic process	GO:0009150	290	0.101	Worm
regulation of symbiosis encompassing mutualism through parasitism	GO:0043903	52	0.100	Mouse
epithelial cell development	GO:0002064	159	0.099
response to superoxide	GO:0000303	16	0.099
cellular response to peptide	GO:1901653	92	0.099
positive regulation of protein phosphorylation	GO:0001934	242	0.098	Mouse
lymphocyte mediated immunity	GO:0002449	139	0.097
positive regulation of lymphocyte activation	GO:0051251	140	0.095
negative regulation of peptidyl serine phosphorylation	GO:0033137	10	0.095	Mouse
regulation of peptidyl lysine acetylation	GO:2000756	22	0.094
spongiotrophoblast layer development	GO:0060712	15	0.094
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.094	Worm
embryonic placenta development	GO:0001892	98	0.094
synaptic transmission	GO:0007268	329	0.094
urogenital system development	GO:0001655	261	0.094	Mouse
cation transport	GO:0006812	399	0.094	Mouse
limb morphogenesis	GO:0035108	149	0.091	Mouse
fibroblast apoptotic process	GO:0044346	9	0.091	Mouse
cellular response to oxygen radical	GO:0071450	14	0.091
positive regulation of response to dna damage stimulus	GO:2001022	14	0.091
endocytosis	GO:0006897	168	0.090
regulation of mapk cascade	GO:0043408	248	0.088
regulation of alpha beta t cell differentiation	GO:0046637	35	0.087
response to hydrogen peroxide	GO:0042542	32	0.087	Mouse
leukocyte activation involved in immune response	GO:0002366	126	0.086
thymus development	GO:0048538	41	0.086	Mouse
regulation of muscle tissue development	GO:1901861	97	0.086	Mouse
positive regulation of neuron differentiation	GO:0045666	141	0.086	Mouse
negative regulation of neuron apoptotic process	GO:0043524	92	0.085	Mouse
regulation of protein kinase activity	GO:0045859	232	0.084
regulation of b cell apoptotic process	GO:0002902	13	0.084	Mouse
positive regulation of interferon alpha production	GO:0032727	4	0.084
ubiquitin dependent protein catabolic process	GO:0006511	129	0.084
post embryonic camera type eye development	GO:0031077	8	0.082	Mouse
purine nucleoside metabolic process	GO:0042278	241	0.082	Worm
leukocyte proliferation	GO:0070661	172	0.082	Mouse
regulation of removal of superoxide radicals	GO:2000121	4	0.081
negative regulation of protein phosphorylation	GO:0001933	126	0.081	Mouse
nitrogen compound transport	GO:0071705	271	0.079
cellular response to hypoxia	GO:0071456	17	0.078	Mouse
ribonucleoside metabolic process	GO:0009119	245	0.077	Worm
regulation of cell projection assembly	GO:0060491	38	0.075
response to molecule of bacterial origin	GO:0002237	143	0.075
chromatin modification	GO:0016568	187	0.075
response to inorganic substance	GO:0010035	96	0.074	Mouse
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	GO:1901028	7	0.074
regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	GO:1900739	3	0.073
ribonucleoside catabolic process	GO:0042454	206	0.073	Worm
erythrocyte differentiation	GO:0030218	88	0.073
response to insulin	GO:0032868	100	0.073
purine nucleotide biosynthetic process	GO:0006164	65	0.073
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.073	Worm
negative regulation of molecular function	GO:0044092	258	0.072	Zebrafish
wound healing	GO:0042060	157	0.072
sphingolipid metabolic process	GO:0006665	45	0.071	Mouse
glucose metabolic process	GO:0006006	92	0.071
myotube differentiation	GO:0014902	105	0.071	Mouse
mapk cascade	GO:0000165	281	0.071
mitotic cell cycle	GO:0000278	195	0.071	Zebrafish Mouse
chromatin organization	GO:0006325	206	0.070
leukocyte mediated immunity	GO:0002443	174	0.069
covalent chromatin modification	GO:0016569	163	0.069
retina development in camera type eye	GO:0060041	119	0.068	Mouse
negative regulation of phosphorylation	GO:0042326	166	0.068	Mouse
cytoplasmic transport	GO:0016482	234	0.068	Mouse
regulation of lymphocyte proliferation	GO:0050670	117	0.067
regulation of protein autophosphorylation	GO:0031952	8	0.067
positive regulation of cellular carbohydrate metabolic process	GO:0010676	29	0.067
endothelial cell differentiation	GO:0045446	41	0.067
negative regulation of cell motility	GO:2000146	61	0.067	Mouse
calcium ion homeostasis	GO:0055074	127	0.067	Mouse
labyrinthine layer blood vessel development	GO:0060716	21	0.067
negative regulation of ossification	GO:0030279	49	0.067	Mouse
signal transduction by p53 class mediator	GO:0072331	51	0.066	Mouse
positive regulation of mapk cascade	GO:0043410	170	0.066
positive regulation of leukocyte apoptotic process	GO:2000108	21	0.066	Mouse
skeletal system development	GO:0001501	356	0.066
rna catabolic process	GO:0006401	29	0.066
liver development	GO:0001889	66	0.065
cellular carbohydrate metabolic process	GO:0044262	119	0.065
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.065
hexose metabolic process	GO:0019318	98	0.065
removal of superoxide radicals	GO:0019430	12	0.064
muscle fiber development	GO:0048747	76	0.064	Mouse
regulation of ossification	GO:0030278	112	0.064	Mouse
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.064	Worm
glycosyl compound catabolic process	GO:1901658	206	0.064	Worm
regulation of protein complex assembly	GO:0043254	83	0.064
small gtpase mediated signal transduction	GO:0007264	97	0.064
activation of innate immune response	GO:0002218	56	0.063
positive regulation of t cell differentiation	GO:0045582	52	0.063
regulation of defense response	GO:0031347	233	0.062
labyrinthine layer development	GO:0060711	49	0.062
regulation of cell size	GO:0008361	72	0.062
apical constriction	GO:0003383	4	0.062
regulation of lymphocyte differentiation	GO:0045619	107	0.062
skin morphogenesis	GO:0043589	38	0.062	Mouse
organophosphate biosynthetic process	GO:0090407	122	0.062
dna damage response signal transduction by p53 class mediator	GO:0030330	19	0.061
peptide hormone secretion	GO:0030072	109	0.061
g1 s transition of mitotic cell cycle	GO:0000082	57	0.061	Mouse
response to lipopolysaccharide	GO:0032496	128	0.061
chromosome segregation	GO:0007059	48	0.061
negative regulation of intracellular transport	GO:0032387	38	0.061	Mouse
purine nucleotide catabolic process	GO:0006195	211	0.060	Worm
interferon gamma production	GO:0032609	67	0.060
cell division	GO:0051301	120	0.060	Zebrafish
regulation of cell activation	GO:0050865	289	0.060
intracellular receptor signaling pathway	GO:0030522	74	0.060
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.060	Mouse
ossification	GO:0001503	216	0.060	Mouse
peptidyl lysine acetylation	GO:0018394	45	0.060
regulation of leukocyte proliferation	GO:0070663	121	0.060
cellular response to abiotic stimulus	GO:0071214	56	0.059	Mouse
nephron epithelium development	GO:0072009	92	0.059	Mouse
gastrulation	GO:0007369	116	0.059
regulation of hormone levels	GO:0010817	211	0.058
cytokine biosynthetic process	GO:0042089	68	0.058
regulation of response to wounding	GO:1903034	189	0.058
regulation of b cell differentiation	GO:0045577	23	0.058
regulation of cytoplasmic transport	GO:1903649	112	0.058	Mouse
lipid transport	GO:0006869	98	0.057
regulation of neutrophil differentiation	GO:0045658	2	0.057
nuclear transport	GO:0051169	139	0.057
nucleoside triphosphate metabolic process	GO:0009141	230	0.057	Worm
regulation of b cell activation	GO:0050864	81	0.057
multicellular organismal homeostasis	GO:0048871	164	0.057	Zebrafish Mouse
anatomical structure homeostasis	GO:0060249	145	0.057	Zebrafish Mouse
nephron development	GO:0072006	109	0.057	Mouse
protein alkylation	GO:0008213	81	0.056
positive regulation of growth	GO:0045927	104	0.055	Mouse
dna modification	GO:0006304	50	0.055
aromatic compound catabolic process	GO:0019439	286	0.055	Worm
negative regulation of cellular component organization	GO:0051129	194	0.055	Zebrafish
positive regulation of nuclear transcribed mrna poly a tail shortening	GO:0060213	4	0.055
single organism nuclear import	GO:1902593	95	0.054
coagulation	GO:0050817	78	0.054
epithelial cell morphogenesis	GO:0003382	41	0.054
regulation of striated muscle cell differentiation	GO:0051153	81	0.054	Mouse
cellular response to lipopolysaccharide	GO:0071222	77	0.054
cellular response to hormone stimulus	GO:0032870	150	0.054
cellular response to superoxide	GO:0071451	14	0.053
muscle system process	GO:0003012	141	0.053
regulation of embryonic development	GO:0045995	71	0.053
b cell differentiation	GO:0030183	78	0.052	Mouse
organonitrogen compound biosynthetic process	GO:1901566	192	0.052
tyrosine phosphorylation of stat1 protein	GO:0042508	3	0.052
cellular response to peptide hormone stimulus	GO:0071375	92	0.051
tissue remodeling	GO:0048771	102	0.050	Mouse
negative regulation of stem cell differentiation	GO:2000737	14	0.050
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator	GO:0042771	24	0.050
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.050	Human Mouse
regulation of nucleotide metabolic process	GO:0006140	169	0.050	Worm
regulation of secretion by cell	GO:1903530	249	0.048
positive regulation of defense response	GO:0031349	124	0.048
nucleoside triphosphate catabolic process	GO:0009143	205	0.048	Worm
regulation of stem cell differentiation	GO:2000736	50	0.048
viral life cycle	GO:0019058	36	0.048	Mouse
pattern recognition receptor signaling pathway	GO:0002221	47	0.047
ras protein signal transduction	GO:0007265	77	0.047
cellular response to cytokine stimulus	GO:0071345	189	0.047
response to acid chemical	GO:0001101	111	0.047	Mouse
meiotic cell cycle	GO:0051321	122	0.047
ear development	GO:0043583	200	0.047	Mouse
regulation of chromatin modification	GO:1903308	57	0.047
regulation of kinase activity	GO:0043549	249	0.047
b cell activation	GO:0042113	161	0.047	Mouse
protein import	GO:0017038	101	0.046
regulation of response to biotic stimulus	GO:0002831	38	0.046
cellular response to biotic stimulus	GO:0071216	92	0.046
meiotic nuclear division	GO:0007126	115	0.046
organelle fission	GO:0048285	170	0.046	Zebrafish
t cell proliferation	GO:0042098	120	0.045	Mouse
regulation of microvillus assembly	GO:0032534	3	0.045
cellular homeostasis	GO:0019725	240	0.045	Mouse
regulation of synaptic vesicle exocytosis	GO:2000300	11	0.044
positive regulation of smooth muscle cell migration	GO:0014911	4	0.044	Mouse
rna 3 end processing	GO:0031123	20	0.044
positive regulation of cell activation	GO:0050867	158	0.044
response to nutrient levels	GO:0031667	109	0.044	Mouse
lung development	GO:0030324	164	0.044
regulation of t cell differentiation	GO:0045580	83	0.044
purine ribonucleoside catabolic process	GO:0046130	205	0.044	Worm
jnk cascade	GO:0007254	72	0.044
positive regulation of alpha beta t cell differentiation	GO:0046638	28	0.044
posttranscriptional regulation of gene expression	GO:0010608	155	0.043	Mouse
ribonucleotide catabolic process	GO:0009261	208	0.043	Worm
positive regulation of kinase activity	GO:0033674	155	0.043
peptide secretion	GO:0002790	114	0.043
regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO:1902041	22	0.043
cytokine mediated signaling pathway	GO:0019221	115	0.043
negative regulation of immune system process	GO:0002683	209	0.043
positive regulation of leukocyte proliferation	GO:0070665	73	0.042
carbohydrate derivative biosynthetic process	GO:1901137	183	0.042	Mouse
regulation of microvillus organization	GO:0032530	3	0.042
regulation of tyrosine phosphorylation of stat1 protein	GO:0042510	2	0.042
divalent metal ion transport	GO:0070838	172	0.042	Mouse
negative regulation of inflammatory response	GO:0050728	61	0.042
regulation of interleukin 8 production	GO:0032677	3	0.042
regulation of protein acetylation	GO:1901983	22	0.041
negative regulation of cytokine production	GO:0001818	84	0.041
negative regulation of hydrolase activity	GO:0051346	71	0.041	Zebrafish
myoblast differentiation	GO:0045445	52	0.041
generation of precursor metabolites and energy	GO:0006091	103	0.041
organic hydroxy compound transport	GO:0015850	93	0.041
regulation of ion transport	GO:0043269	215	0.040	Mouse
regulation of neuron projection development	GO:0010975	169	0.040
negative regulation of leukocyte differentiation	GO:1902106	51	0.040
cellular response to lipid	GO:0071396	145	0.040
negative regulation of cell cycle	GO:0045786	123	0.040	Zebrafish Mouse
carbohydrate derivative catabolic process	GO:1901136	231	0.040	Worm
rna processing	GO:0006396	105	0.040
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.040
negative regulation of protein transport	GO:0051224	46	0.040
dephosphorylation	GO:0016311	129	0.039	Mouse
appendage morphogenesis	GO:0035107	149	0.039	Mouse
lipid localization	GO:0010876	126	0.039
amide transport	GO:0042886	138	0.039
epithelial tube morphogenesis	GO:0060562	303	0.039	Mouse
inflammatory response	GO:0006954	244	0.039
negative regulation of tumor necrosis factor biosynthetic process	GO:0042536	1	0.038
cellular response to organic cyclic compound	GO:0071407	87	0.038
guanosine containing compound catabolic process	GO:1901069	144	0.038	Worm
regulation of cellular catabolic process	GO:0031329	242	0.038	Worm
regulation of protein localization to nucleus	GO:1900180	60	0.038
t helper cell differentiation	GO:0042093	28	0.038
gliogenesis	GO:0042063	141	0.038
modification dependent macromolecule catabolic process	GO:0043632	133	0.037
regulation of erk1 and erk2 cascade	GO:0070372	71	0.037
negative regulation of mitotic cell cycle	GO:0045930	58	0.037	Zebrafish Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.037
ribose phosphate biosynthetic process	GO:0046390	59	0.037
mesenchymal cell differentiation	GO:0048762	107	0.037	Mouse
response to oxygen radical	GO:0000305	16	0.037
negative regulation of organelle organization	GO:0010639	90	0.037	Zebrafish
regulation of mrna stability	GO:0043488	23	0.037
hepaticobiliary system development	GO:0061008	67	0.037
regulation of system process	GO:0044057	200	0.037
positive regulation of nucleotide metabolic process	GO:0045981	114	0.037	Worm
regulation of cellular component size	GO:0032535	121	0.037
positive regulation of gene silencing by mirna	GO:2000637	1	0.036
syncytium formation by plasma membrane fusion	GO:0000768	42	0.036
negative regulation of defense response	GO:0031348	77	0.036
positive regulation of fat cell differentiation	GO:0045600	32	0.036
regulation of osteoclast differentiation	GO:0045670	36	0.036
negative regulation of multi organism process	GO:0043901	68	0.036
cellularization	GO:0007349	1	0.036
intracellular protein transport	GO:0006886	204	0.035
negative regulation of t cell activation	GO:0050868	65	0.035
negative regulation of neuron death	GO:1901215	98	0.035	Mouse
endothelium development	GO:0003158	45	0.035
neural tube development	GO:0021915	160	0.035
nuclear division	GO:0000280	158	0.035	Zebrafish
nucleocytoplasmic transport	GO:0006913	139	0.035
cell adhesion	GO:0007155	329	0.034	Mouse
response to drug	GO:0042493	75	0.034	Mouse
skeletal muscle cell differentiation	GO:0035914	66	0.034
regulation of response to dna damage stimulus	GO:2001020	34	0.034	Human
cell activation involved in immune response	GO:0002263	126	0.034
dendrite development	GO:0016358	115	0.034
somitogenesis	GO:0001756	69	0.034
hexose transport	GO:0008645	56	0.034
positive regulation of podosome assembly	GO:0071803	3	0.034
cytokine metabolic process	GO:0042107	71	0.034
purine containing compound catabolic process	GO:0072523	213	0.034	Worm
positive regulation of carbohydrate metabolic process	GO:0045913	30	0.034
t cell apoptotic process	GO:0070231	39	0.034	Mouse
regulation of osteoblast differentiation	GO:0045667	67	0.034
nucleoside phosphate metabolic process	GO:0006753	338	0.034	Worm

Mcl1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.135
cancer	DOID:162	0.060
organ system cancer	DOID:0050686	0.047

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