IMP: Integrative Multi-species Prediction

Mus musculus

28 known processes

Mepe

matrix extracellular phosphoglycoprotein with ASARM motif (bone)

(Aliases: Of45)

Ensembl: ENSMUSG00000053863
Entrez: 94111
UniProtKB: Q8K4L6

Process Predictions
Disease Predictions

Mepe biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
ion transmembrane transport	GO:0034220	361	0.561
transmembrane transport	GO:0055085	412	0.195
leukocyte differentiation	GO:0002521	342	0.137
cation transmembrane transport	GO:0098655	266	0.110
striated muscle tissue development	GO:0014706	293	0.098
gland development	GO:0048732	330	0.094
regulation of cellular amino acid metabolic process	GO:0006521	5	0.093
cellular ketone metabolic process	GO:0042180	84	0.093
inorganic ion transmembrane transport	GO:0098660	234	0.089
nitrogen compound transport	GO:0071705	271	0.080
apoptotic signaling pathway	GO:0097190	306	0.077
amine metabolic process	GO:0009308	45	0.076
regulation of membrane potential	GO:0042391	192	0.072
inorganic cation transmembrane transport	GO:0098662	207	0.070
response to light stimulus	GO:0009416	135	0.065
epithelial cell development	GO:0002064	159	0.064
spermatogenesis	GO:0007283	284	0.064
muscle system process	GO:0003012	141	0.061
muscle tissue development	GO:0060537	308	0.057
cellular response to lipid	GO:0071396	145	0.057
calcium ion transport	GO:0006816	159	0.057
regulation of cellular amine metabolic process	GO:0033238	20	0.054
camera type eye development	GO:0043010	266	0.053
regulation of system process	GO:0044057	200	0.053
regulation of peptide secretion	GO:0002791	77	0.053
response to organic cyclic compound	GO:0014070	198	0.051
response to nutrient levels	GO:0031667	109	0.050
skin development	GO:0043588	220	0.050
response to organonitrogen compound	GO:0010243	246	0.050
cellular amine metabolic process	GO:0044106	44	0.049
male sex differentiation	GO:0046661	109	0.047
negative regulation of cell proliferation	GO:0008285	296	0.044
axonogenesis	GO:0007409	274	0.044
cellular chemical homeostasis	GO:0055082	215	0.043
regulation of epithelial cell proliferation	GO:0050678	141	0.043
calcium ion transmembrane transport	GO:0070588	85	0.043
regulation of homeostatic process	GO:0032844	182	0.043
cellular amino acid metabolic process	GO:0006520	103	0.043
divalent metal ion transport	GO:0070838	172	0.043
epidermis development	GO:0008544	187	0.042
transmission of nerve impulse	GO:0019226	76	0.041
t cell activation	GO:0042110	289	0.040
rhythmic process	GO:0048511	174	0.039
muscle cell development	GO:0055001	133	0.039
stem cell development	GO:0048864	219	0.038
lymphocyte differentiation	GO:0030098	242	0.038
response to extracellular stimulus	GO:0009991	127	0.036
regulation of transmembrane transport	GO:0034762	128	0.036
regulation of secretion	GO:0051046	274	0.036
multicellular organismal response to stress	GO:0033555	62	0.034
cellular homeostasis	GO:0019725	240	0.033
anion transport	GO:0006820	177	0.033
placenta development	GO:0001890	140	0.033
regulation of secretion by cell	GO:1903530	249	0.032
mesenchymal cell differentiation	GO:0048762	107	0.032
homeostasis of number of cells	GO:0048872	210	0.032
negative regulation of cellular protein metabolic process	GO:0032269	247	0.032
blood circulation	GO:0008015	195	0.031
cation transport	GO:0006812	399	0.031
response to radiation	GO:0009314	165	0.031
ossification	GO:0001503	216	0.031
divalent inorganic cation transport	GO:0072511	178	0.031
immune effector process	GO:0002252	321	0.031
stem cell differentiation	GO:0048863	268	0.030
respiratory system development	GO:0060541	190	0.030
hematopoietic progenitor cell differentiation	GO:0002244	143	0.030
sodium ion transport	GO:0006814	73	0.030
multicellular organismal signaling	GO:0035637	91	0.029
regulation of cellular ketone metabolic process	GO:0010565	66	0.029
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.029
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.029
heart morphogenesis	GO:0003007	178	0.029
cardiac chamber development	GO:0003205	108	0.029
fertilization	GO:0009566	127	0.029
cardiac muscle tissue development	GO:0048738	130	0.028
protein catabolic process	GO:0030163	221	0.028
regulation of organ morphogenesis	GO:2000027	144	0.028
regulation of muscle tissue development	GO:1901861	97	0.028
negative regulation of protein metabolic process	GO:0051248	282	0.028
regulation of hormone levels	GO:0010817	211	0.027
regulation of ion transport	GO:0043269	215	0.027
response to acid chemical	GO:0001101	111	0.026
regulation of lymphocyte activation	GO:0051249	240	0.026
germ cell development	GO:0007281	185	0.026
embryonic placenta development	GO:0001892	98	0.026
nuclear transport	GO:0051169	139	0.026
striated muscle contraction	GO:0006941	45	0.025
regulation of lymphocyte differentiation	GO:0045619	107	0.025
developmental maturation	GO:0021700	193	0.025
cellular response to cytokine stimulus	GO:0071345	189	0.025
posttranscriptional regulation of gene expression	GO:0010608	155	0.024
leukocyte proliferation	GO:0070661	172	0.024
protein modification by small protein conjugation or removal	GO:0070647	207	0.024
cardiac ventricle development	GO:0003231	83	0.024
positive regulation of cellular amine metabolic process	GO:0033240	5	0.023
response to lipopolysaccharide	GO:0032496	128	0.023
regulation of cell activation	GO:0050865	289	0.023
regulation of metal ion transport	GO:0010959	106	0.023
sodium ion transmembrane transport	GO:0035725	49	0.023
cellular nitrogen compound catabolic process	GO:0044270	280	0.023
cellular response to organic cyclic compound	GO:0071407	87	0.023
protein modification by small protein conjugation	GO:0032446	187	0.022
locomotory behavior	GO:0007626	195	0.022
nucleocytoplasmic transport	GO:0006913	139	0.022
negative regulation of phosphorus metabolic process	GO:0010563	184	0.022
negative regulation of cellular component organization	GO:0051129	194	0.022
male gonad development	GO:0008584	88	0.022
oxidation reduction process	GO:0055114	342	0.022
regulation of ovulation	GO:0060278	3	0.022
intracellular protein transport	GO:0006886	204	0.022
organic hydroxy compound metabolic process	GO:1901615	203	0.021
regulation of protein transport	GO:0051223	163	0.021
amide transport	GO:0042886	138	0.021
organ growth	GO:0035265	117	0.021
protein maturation	GO:0051604	176	0.021
regulation of t cell proliferation	GO:0042129	92	0.021
learning	GO:0007612	98	0.021
regulation of protein localization	GO:0032880	231	0.021
multicellular organism growth	GO:0035264	161	0.020
male gamete generation	GO:0048232	285	0.020
digestive system development	GO:0055123	200	0.020
positive regulation of protein transport	GO:0051222	93	0.020
sulfur compound metabolic process	GO:0006790	100	0.020
epithelial cell maturation involved in prostate gland development	GO:0060743	4	0.020
hexose metabolic process	GO:0019318	98	0.020
tube formation	GO:0035148	140	0.019
brain segmentation	GO:0035284	3	0.019
macromolecule catabolic process	GO:0009057	281	0.019
sensory perception	GO:0007600	245	0.019
response to testosterone	GO:0033574	3	0.019
positive regulation of protein modification process	GO:0031401	299	0.019
heart contraction	GO:0060047	93	0.019
cellular macromolecule catabolic process	GO:0044265	206	0.019
dephosphorylation	GO:0016311	129	0.019
detection of stimulus	GO:0051606	84	0.019
regulation of neuron differentiation	GO:0045664	281	0.019
cell type specific apoptotic process	GO:0097285	268	0.018
regulation of cell projection organization	GO:0031344	206	0.018
cellular response to nutrient levels	GO:0031669	64	0.018
protein targeting	GO:0006605	143	0.018
cytoplasmic transport	GO:0016482	234	0.018
carbohydrate metabolic process	GO:0005975	230	0.018
bmp signaling pathway	GO:0030509	93	0.018
epithelial cell proliferation	GO:0050673	174	0.018
blastocyst development	GO:0001824	80	0.017
mesenchyme development	GO:0060485	152	0.017
regulation of peptide transport	GO:0090087	91	0.017
stem cell maintenance	GO:0019827	130	0.017
protein localization to nucleus	GO:0034504	121	0.017
regulation of blood circulation	GO:1903522	93	0.017
negative regulation of intracellular signal transduction	GO:1902532	167	0.017
myeloid cell differentiation	GO:0030099	233	0.017
cell maturation	GO:0048469	127	0.017
protein ubiquitination	GO:0016567	171	0.017
erythrocyte differentiation	GO:0030218	88	0.017
cardiac chamber morphogenesis	GO:0003206	93	0.017
carbohydrate homeostasis	GO:0033500	128	0.017
hindbrain development	GO:0030902	128	0.016
positive regulation of antimicrobial peptide production	GO:0002225	1	0.016
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.016
regulation of auditory receptor cell differentiation	GO:0045607	4	0.016
muscle cell differentiation	GO:0042692	261	0.016
negative regulation of cellular amine metabolic process	GO:0033239	1	0.016
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.016
fear response	GO:0042596	33	0.016
cellular ion homeostasis	GO:0006873	165	0.016
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.016
regulation of angiotensin levels in blood	GO:0002002	4	0.016
rna processing	GO:0006396	105	0.016
peptide hormone secretion	GO:0030072	109	0.016
membrane depolarization	GO:0051899	64	0.016
fat cell differentiation	GO:0045444	160	0.016
heterocycle catabolic process	GO:0046700	280	0.016
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.015
development of primary sexual characteristics	GO:0045137	143	0.015
negative regulation of molecular function	GO:0044092	258	0.015
cellular response to food	GO:0071240	1	0.015
intrinsic apoptotic signaling pathway	GO:0097193	132	0.015
chemotaxis	GO:0006935	247	0.015
glucose homeostasis	GO:0042593	128	0.015
organonitrogen compound biosynthetic process	GO:1901566	192	0.015
morphogenesis of a branching epithelium	GO:0061138	193	0.015
stem cell proliferation	GO:0072089	117	0.015
negative regulation of lymphocyte activation	GO:0051250	91	0.015
auditory receptor cell differentiation	GO:0042491	37	0.015
cellular response to organonitrogen compound	GO:0071417	145	0.015
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.015
positive regulation of antimicrobial humoral response	GO:0002760	2	0.015
regulation of establishment of protein localization	GO:0070201	181	0.015
cellular response to extracellular stimulus	GO:0031668	81	0.015
learning or memory	GO:0007611	148	0.015
regulation of mapk cascade	GO:0043408	248	0.015
hormone secretion	GO:0046879	128	0.015
peptide transport	GO:0015833	133	0.015
cellular response to oxidative stress	GO:0034599	76	0.015
organic acid transport	GO:0015849	101	0.015
regulation of systemic arterial blood pressure	GO:0003073	61	0.015
protein processing	GO:0016485	163	0.014
insulin secretion	GO:0030073	89	0.014
sensory organ morphogenesis	GO:0090596	242	0.014
regulation of ossification	GO:0030278	112	0.014
negative regulation of phosphate metabolic process	GO:0045936	184	0.014
regulation of ion transmembrane transport	GO:0034765	119	0.014
glycoprotein metabolic process	GO:0009100	116	0.014
response to inorganic substance	GO:0010035	96	0.014
circulatory system process	GO:0003013	197	0.014
cellular response to glucose stimulus	GO:0071333	45	0.014
metal ion homeostasis	GO:0055065	189	0.014
negative regulation of neuron apoptotic process	GO:0043524	92	0.014
cation homeostasis	GO:0055080	212	0.014
regulation of neural retina development	GO:0061074	3	0.014
cognition	GO:0050890	149	0.014
negative regulation of cell development	GO:0010721	169	0.014
negative regulation of protein modification process	GO:0031400	163	0.014
retina development in camera type eye	GO:0060041	119	0.013
notch signaling pathway	GO:0007219	71	0.013
positive regulation of secretion by cell	GO:1903532	114	0.013
morphogenesis of a branching structure	GO:0001763	203	0.013
antimicrobial peptide biosynthetic process	GO:0002777	2	0.013
monosaccharide metabolic process	GO:0005996	106	0.013
mapk cascade	GO:0000165	281	0.013
cellular response to starvation	GO:0009267	57	0.013
lung development	GO:0030324	164	0.013
regulation of organelle organization	GO:0033043	289	0.013
peptidyl amino acid modification	GO:0018193	336	0.013
circadian rhythm	GO:0007623	114	0.013
cellular response to testosterone stimulus	GO:0071394	1	0.013
regulation of action potential	GO:0098900	4	0.013
muscle contraction	GO:0006936	101	0.013
extracellular structure organization	GO:0043062	148	0.013
hormone metabolic process	GO:0042445	86	0.013
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.013
response to starvation	GO:0042594	65	0.013
regulation of calcium ion transport	GO:0051924	69	0.013
hair follicle development	GO:0001942	85	0.013
cellular response to monosaccharide stimulus	GO:0071326	47	0.013
multicellular organismal homeostasis	GO:0048871	164	0.013
chromatin organization	GO:0006325	206	0.013
extrinsic apoptotic signaling pathway	GO:0097191	126	0.013
primary neural tube formation	GO:0014020	95	0.013
response to oxygen levels	GO:0070482	62	0.013
mesoderm formation	GO:0001707	62	0.013
blastocyst formation	GO:0001825	33	0.012
positive regulation of nucleotide metabolic process	GO:0045981	114	0.012
regulation of t cell activation	GO:0050863	170	0.012
cellular carbohydrate metabolic process	GO:0044262	119	0.012
positive regulation of protein phosphorylation	GO:0001934	242	0.012
odontogenesis	GO:0042476	78	0.012
molting cycle	GO:0042303	90	0.012
regulation of tumor necrosis factor production	GO:0032680	49	0.012
action potential	GO:0001508	78	0.012
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.012
regulation of cytokine production	GO:0001817	266	0.012
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.012
regulation of cellular component biogenesis	GO:0044087	181	0.012
innate immune response	GO:0045087	157	0.012
negative regulation of insulin secretion involved in cellular response to glucose stimulus	GO:0061179	4	0.012
nephron development	GO:0072006	109	0.012
calcium ion homeostasis	GO:0055074	127	0.012
cell killing	GO:0001906	67	0.012
sensory perception of sound	GO:0007605	97	0.012
mitochondrion organization	GO:0007005	134	0.012
regulation of intracellular transport	GO:0032386	159	0.012
palate development	GO:0060021	76	0.012
spermatid differentiation	GO:0048515	115	0.012
formation of primary germ layer	GO:0001704	77	0.012
positive regulation of cytokine production	GO:0001819	174	0.012
cell adhesion	GO:0007155	329	0.012
dendrite development	GO:0016358	115	0.012
mesenchymal cell development	GO:0014031	93	0.012
regulation of anatomical structure size	GO:0090066	178	0.012
embryonic organ morphogenesis	GO:0048562	276	0.012
t cell proliferation	GO:0042098	120	0.012
wnt signaling pathway	GO:0016055	188	0.012
defense response to virus	GO:0051607	68	0.011
negative regulation of phosphorylation	GO:0042326	166	0.011
ribonucleotide catabolic process	GO:0009261	208	0.011
amino acid transport	GO:0006865	61	0.011
energy derivation by oxidation of organic compounds	GO:0015980	77	0.011
regulation of hydrolase activity	GO:0051336	246	0.011
nucleobase containing small molecule metabolic process	GO:0055086	352	0.011
neuron projection guidance	GO:0097485	141	0.011
response to peptide hormone	GO:0043434	127	0.011
b cell differentiation	GO:0030183	78	0.011
extracellular matrix organization	GO:0030198	147	0.011
ubiquitin dependent protein catabolic process	GO:0006511	129	0.011
lymphocyte proliferation	GO:0046651	164	0.011
cardiac muscle contraction	GO:0060048	32	0.011
inner ear receptor cell differentiation	GO:0060113	61	0.011
ribonucleoside metabolic process	GO:0009119	245	0.011
regulation of angiotensin metabolic process	GO:0060177	4	0.011
purine containing compound metabolic process	GO:0072521	311	0.011
cellular response to inorganic substance	GO:0071241	37	0.011
modification dependent protein catabolic process	GO:0019941	133	0.011
development of primary male sexual characteristics	GO:0046546	88	0.011
gonad development	GO:0008406	141	0.011
chromatin modification	GO:0016568	187	0.011
entry into cell of other organism involved in symbiotic interaction	GO:0051806	15	0.011
purine nucleoside metabolic process	GO:0042278	241	0.011
ras protein signal transduction	GO:0007265	77	0.011
organophosphate biosynthetic process	GO:0090407	122	0.011
carbohydrate derivative biosynthetic process	GO:1901137	183	0.011
spermatid development	GO:0007286	108	0.011
cellular response to steroid hormone stimulus	GO:0071383	33	0.010
modification dependent macromolecule catabolic process	GO:0043632	133	0.010
cellular response to carbohydrate stimulus	GO:0071322	50	0.010
carboxylic acid transport	GO:0046942	100	0.010
monocarboxylic acid metabolic process	GO:0032787	191	0.010
synapse organization	GO:0050808	125	0.010
positive regulation of t cell activation	GO:0050870	101	0.010
regulation of protein catabolic process	GO:0042176	108	0.010
nucleoside monophosphate metabolic process	GO:0009123	85	0.010
neuron migration	GO:0001764	122	0.010
visual behavior	GO:0007632	45	0.010
mammary gland epithelium development	GO:0061180	65	0.010
cytokine production	GO:0001816	319	0.010
response to molecule of bacterial origin	GO:0002237	143	0.010
nucleoside phosphate catabolic process	GO:1901292	222	0.010
axon guidance	GO:0007411	141	0.010

Mepe disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.016
nervous system disease	DOID:863	0.016
disease of metabolism	DOID:0014667	0.013
musculoskeletal system disease	DOID:17	0.012
connective tissue disease	DOID:65	0.012
bone disease	DOID:0080001	0.012

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