IMP: Integrative Multi-species Prediction

Mus musculus

108 known processes

Six5

sine oculis-related homeobox 5 homolog (Drosophila)

(Aliases: TrexBF,MDMAHP,Dmahp)

Ensembl: ENSMUSG00000040841
Entrez: 20475
UniProtKB: P70178

Process Predictions
Disease Predictions

Six5 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
embryonic organ morphogenesis	GO:0048562	276	0.958	Mouse
epithelial tube morphogenesis	GO:0060562	303	0.869	Mouse
morphogenesis of a branching structure	GO:0001763	203	0.675	Mouse
skeletal system morphogenesis	GO:0048705	203	0.658	Mouse
lung development	GO:0030324	164	0.617
morphogenesis of embryonic epithelium	GO:0016331	159	0.586	Mouse
forebrain development	GO:0030900	302	0.580	Mouse
blood vessel morphogenesis	GO:0048514	285	0.554	Mouse
developmental maturation	GO:0021700	193	0.552	Mouse
embryonic skeletal system development	GO:0048706	120	0.549	Mouse
urogenital system development	GO:0001655	261	0.531	Mouse
branching morphogenesis of an epithelial tube	GO:0048754	159	0.494	Mouse
cardiac chamber morphogenesis	GO:0003206	93	0.487
neural tube development	GO:0021915	160	0.485
stem cell differentiation	GO:0048863	268	0.473	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.460
striated muscle tissue development	GO:0014706	293	0.451	Mouse
morphogenesis of a branching epithelium	GO:0061138	193	0.420	Mouse
skeletal system development	GO:0001501	356	0.416	Mouse
stem cell proliferation	GO:0072089	117	0.403	Mouse
cartilage development	GO:0051216	140	0.403	Mouse
negative regulation of nervous system development	GO:0051961	156	0.395	Mouse
negative regulation of cell development	GO:0010721	169	0.394	Mouse
cell adhesion	GO:0007155	329	0.393
regulation of stem cell proliferation	GO:0072091	78	0.392	Mouse
embryonic skeletal system morphogenesis	GO:0048704	91	0.389	Mouse
non canonical wnt signaling pathway	GO:0035567	33	0.376
central nervous system neuron differentiation	GO:0021953	162	0.373
heart morphogenesis	GO:0003007	178	0.370	Mouse
neural tube formation	GO:0001841	108	0.367
renal tubule development	GO:0061326	87	0.365	Mouse
respiratory tube development	GO:0030323	167	0.362
nephron epithelium development	GO:0072009	92	0.357	Mouse
neural tube closure	GO:0001843	90	0.349
skin development	GO:0043588	220	0.348
stem cell development	GO:0048864	219	0.345	Mouse
nephron tubule morphogenesis	GO:0072078	68	0.338	Mouse
positive regulation of nervous system development	GO:0051962	221	0.335
cell fate commitment	GO:0045165	210	0.327	Mouse Worm
inner ear morphogenesis	GO:0042472	101	0.316	Mouse
embryonic epithelial tube formation	GO:0001838	130	0.316	Mouse
t cell differentiation	GO:0030217	174	0.310
regulation of cellular amino acid metabolic process	GO:0006521	5	0.308
wnt signaling pathway	GO:0016055	188	0.303	Mouse
retinal blood vessel morphogenesis	GO:0061304	3	0.298
actin cytoskeleton organization	GO:0030036	220	0.296	Mouse
regulation of ossification	GO:0030278	112	0.288	Mouse
establishment of planar polarity involved in neural tube closure	GO:0090177	15	0.282
renal tubule morphogenesis	GO:0061333	72	0.280	Mouse
leukocyte differentiation	GO:0002521	342	0.263
progesterone secretion	GO:0042701	1	0.262
mesoderm formation	GO:0001707	62	0.261	Mouse Worm
positive regulation of cell development	GO:0010720	237	0.259
lymphocyte differentiation	GO:0030098	242	0.252
regulation of cellular amine metabolic process	GO:0033238	20	0.239
trachea cartilage morphogenesis	GO:0060535	4	0.239
ureteric bud development	GO:0001657	94	0.235	Mouse
limb development	GO:0060173	166	0.231
positive regulation of cell death	GO:0010942	224	0.222
cellular amine metabolic process	GO:0044106	44	0.205
formation of primary germ layer	GO:0001704	77	0.203	Mouse Worm
regulation of cell adhesion	GO:0030155	154	0.200
connective tissue development	GO:0061448	179	0.194	Mouse Fly
regulation of apoptotic signaling pathway	GO:2001233	197	0.193
artery development	GO:0060840	53	0.192	Mouse
mesonephric epithelium development	GO:0072163	94	0.190	Mouse
embryonic appendage morphogenesis	GO:0035113	126	0.190
cochlea morphogenesis	GO:0090103	22	0.189	Mouse
epithelial tube formation	GO:0072175	130	0.187	Mouse
regulation of neural precursor cell proliferation	GO:2000177	70	0.183	Mouse
muscular septum morphogenesis	GO:0003150	4	0.180
aorta development	GO:0035904	23	0.179	Mouse
axonogenesis	GO:0007409	274	0.178
mesonephros development	GO:0001823	97	0.178	Mouse
gland development	GO:0048732	330	0.175	Mouse
central nervous system neuron development	GO:0021954	67	0.173
pallium development	GO:0021543	120	0.172
b cell activation	GO:0042113	161	0.171
nephron epithelium morphogenesis	GO:0072088	68	0.170	Mouse
ear morphogenesis	GO:0042471	118	0.170	Mouse
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.165
primary neural tube formation	GO:0014020	95	0.164
regulation of cellular catabolic process	GO:0031329	242	0.163
aortic valve morphogenesis	GO:0003180	4	0.163
cellular ketone metabolic process	GO:0042180	84	0.162
cellular homeostasis	GO:0019725	240	0.160
spermatogenesis	GO:0007283	284	0.159
neural tube patterning	GO:0021532	43	0.158
regulation of muscle tissue development	GO:1901861	97	0.158	Mouse
cell cell signaling involved in mammary gland development	GO:0060764	2	0.158
kidney development	GO:0001822	213	0.157	Mouse
limbic system development	GO:0021761	72	0.156
rho protein signal transduction	GO:0007266	32	0.152
aorta morphogenesis	GO:0035909	22	0.151	Mouse
tube formation	GO:0035148	140	0.149	Mouse
neuron migration	GO:0001764	122	0.147
appendage development	GO:0048736	166	0.147
mesonephric tubule morphogenesis	GO:0072171	63	0.147	Mouse
respiratory system development	GO:0060541	190	0.143	Mouse
cation homeostasis	GO:0055080	212	0.143
ear development	GO:0043583	200	0.142	Mouse
t cell differentiation in thymus	GO:0033077	77	0.141
nephron development	GO:0072006	109	0.141	Mouse
branching involved in ureteric bud morphogenesis	GO:0001658	56	0.139	Mouse
muscle tissue development	GO:0060537	308	0.138	Mouse
sensory organ morphogenesis	GO:0090596	242	0.137	Mouse
bone mineralization	GO:0030282	54	0.137
hippocampus development	GO:0021766	52	0.134
embryonic heart tube development	GO:0035050	65	0.133
wnt signaling pathway involved in forebrain neuroblast division	GO:0021874	2	0.133
negative regulation of leukocyte differentiation	GO:1902106	51	0.131
regulation of ras gtpase activity	GO:0032318	88	0.128
telencephalon development	GO:0021537	186	0.127	Mouse
mesoderm development	GO:0007498	100	0.126	Mouse Worm Fly
neuron projection guidance	GO:0097485	141	0.125
negative regulation of neuron differentiation	GO:0045665	101	0.124	Mouse
small gtpase mediated signal transduction	GO:0007264	97	0.123
wnt signaling pathway planar cell polarity pathway	GO:0060071	27	0.122
maintenance of cell number	GO:0098727	3	0.121
ras protein signal transduction	GO:0007265	77	0.121
regulation of cell projection organization	GO:0031344	206	0.121
regulation of nucleotide metabolic process	GO:0006140	169	0.121
hindbrain development	GO:0030902	128	0.120
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.120
somitogenesis	GO:0001756	69	0.119
negative regulation of cell proliferation	GO:0008285	296	0.116
gastrulation	GO:0007369	116	0.116	Mouse Worm
regulation of secretion by cell	GO:1903530	249	0.116
muscle cell differentiation	GO:0042692	261	0.116	Mouse Fly
myeloid cell differentiation	GO:0030099	233	0.115
regulation of establishment of planar polarity involved in neural tube closure	GO:0090178	15	0.115
embryonic nail plate morphogenesis	GO:0035880	3	0.115
cardiac right atrium morphogenesis	GO:0003213	3	0.114
sensory perception	GO:0007600	245	0.112	Mouse
metal ion homeostasis	GO:0055065	189	0.112
mesoderm morphogenesis	GO:0048332	64	0.112	Mouse Worm
regulation of cellular ketone metabolic process	GO:0010565	66	0.112
nephron morphogenesis	GO:0072028	69	0.111	Mouse
digestive tract morphogenesis	GO:0048546	147	0.111	Mouse Worm
cell type specific apoptotic process	GO:0097285	268	0.111	Mouse
notch signaling pathway	GO:0007219	71	0.111
regulation of neuron differentiation	GO:0045664	281	0.111	Mouse
mesonephric tubule development	GO:0072164	94	0.110	Mouse
outflow tract morphogenesis	GO:0003151	53	0.108	Mouse
mesenchymal cell differentiation	GO:0048762	107	0.106	Mouse
thymus development	GO:0048538	41	0.106	Mouse
neuroblast differentiation	GO:0014016	2	0.105	Mouse
gliogenesis	GO:0042063	141	0.104
embryonic heart tube morphogenesis	GO:0003143	51	0.103
myoblast differentiation	GO:0045445	52	0.102
epidermis development	GO:0008544	187	0.102
central nervous system vasculogenesis	GO:0022009	3	0.101
regulation of hydrolase activity	GO:0051336	246	0.101
renal system development	GO:0072001	225	0.101	Mouse
regulation of epithelial to mesenchymal transition	GO:0010717	22	0.100
negative regulation of neuron projection development	GO:0010977	50	0.099
regulation of neuron projection development	GO:0010975	169	0.098
cardiac ventricle development	GO:0003231	83	0.098
nephric duct formation	GO:0072179	4	0.098
positive regulation of secondary heart field cardioblast proliferation	GO:0072513	4	0.097	Mouse
regulation of tight junction assembly	GO:2000810	2	0.097
regulation of rho gtpase activity	GO:0032319	58	0.096
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation	GO:0003257	3	0.096
skeletal muscle organ development	GO:0060538	163	0.096	Mouse
establishment of planar polarity of embryonic epithelium	GO:0042249	16	0.096
determination of left right symmetry	GO:0007368	80	0.095
amine metabolic process	GO:0009308	45	0.095
vascular smooth muscle cell differentiation	GO:0035886	11	0.094
positive regulation of apoptotic process	GO:0043065	217	0.094
embryonic digit morphogenesis	GO:0042733	56	0.093
regulation of homeostatic process	GO:0032844	182	0.092
mesonephric duct morphogenesis	GO:0072180	4	0.092
regulation of neuron death	GO:1901214	134	0.091	Mouse
regulation of reproductive process	GO:2000241	66	0.091
regulation of cartilage development	GO:0061035	44	0.090	Mouse
positive regulation of neuroblast proliferation	GO:0002052	19	0.090
glial cell differentiation	GO:0010001	131	0.090
cardiac chamber development	GO:0003205	108	0.090
thymic t cell selection	GO:0045061	22	0.090
cerebellum vasculature development	GO:0061300	1	0.090
planar cell polarity pathway involved in ventricular septum morphogenesis	GO:0061348	2	0.089
tongue development	GO:0043586	18	0.089	Mouse
ureteric bud morphogenesis	GO:0060675	62	0.089	Mouse
appendage morphogenesis	GO:0035107	149	0.089
embryonic limb morphogenesis	GO:0030326	126	0.089
forebrain neuron differentiation	GO:0021879	52	0.088
planar cell polarity pathway involved in outflow tract morphogenesis	GO:0061347	2	0.088
bone development	GO:0060348	120	0.088
mesenchyme development	GO:0060485	152	0.087	Mouse
regulation of cellular response to stress	GO:0080135	159	0.087
regulation of bmp signaling pathway	GO:0030510	60	0.086
muscle system process	GO:0003012	141	0.086
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	GO:0014834	3	0.086
regulation of system process	GO:0044057	200	0.086
regulation of protein transport	GO:0051223	163	0.084
neural precursor cell proliferation	GO:0061351	121	0.084	Mouse
astrocyte differentiation	GO:0048708	43	0.084
parathyroid hormone secretion	GO:0035898	2	0.083
cell proliferation involved in outflow tract morphogenesis	GO:0061325	4	0.083
bone morphogenesis	GO:0060349	78	0.083
megakaryocyte differentiation	GO:0030219	26	0.082
regulation of wnt signaling pathway	GO:0030111	123	0.082	Mouse
endocardial cushion to mesenchymal transition involved in heart valve formation	GO:0003199	4	0.082
negative regulation of hepatocyte differentiation	GO:0070367	1	0.081
multicellular organismal homeostasis	GO:0048871	164	0.081
negative regulation of mitotic cell cycle embryonic	GO:0045976	2	0.081
cardiac muscle tissue development	GO:0048738	130	0.081
angiogenesis	GO:0001525	201	0.080
cranial nerve development	GO:0021545	41	0.080	Mouse
sympathetic nervous system development	GO:0048485	22	0.080
regulation of secretion	GO:0051046	274	0.079
lung morphogenesis	GO:0060425	50	0.078
skeletal muscle cell differentiation	GO:0035914	66	0.078	Mouse
homeostasis of number of cells	GO:0048872	210	0.078
cell migration involved in endocardial cushion formation	GO:0003273	3	0.078
camera type eye development	GO:0043010	266	0.076
locomotory behavior	GO:0007626	195	0.076
clara cell differentiation	GO:0060486	4	0.075
positive regulation of protein modification process	GO:0031401	299	0.075
regulation of establishment of planar polarity	GO:0090175	28	0.075
organelle fission	GO:0048285	170	0.075
negative regulation of immune system process	GO:0002683	209	0.075
wound healing	GO:0042060	157	0.074
apoptotic signaling pathway	GO:0097190	306	0.074
organophosphate catabolic process	GO:0046434	232	0.074
ossification	GO:0001503	216	0.074	Mouse
forebrain neuron development	GO:0021884	30	0.074
spinal cord ventral commissure morphogenesis	GO:0021965	2	0.074
establishment or maintenance of cell polarity	GO:0007163	86	0.074
bmp signaling pathway	GO:0030509	93	0.074
central nervous system neuron axonogenesis	GO:0021955	28	0.073
peptidyl amino acid modification	GO:0018193	336	0.071
central nervous system projection neuron axonogenesis	GO:0021952	21	0.071
tissue homeostasis	GO:0001894	115	0.071
b cell differentiation	GO:0030183	78	0.070
metencephalon development	GO:0022037	89	0.070
positive regulation of kinase activity	GO:0033674	155	0.070
histone modification	GO:0016570	159	0.070
nucleoside triphosphate catabolic process	GO:0009143	205	0.070
renal vesicle induction	GO:0072034	3	0.069
rac protein signal transduction	GO:0016601	13	0.069
forebrain generation of neurons	GO:0021872	63	0.069
cardiac right ventricle formation	GO:0003219	3	0.068
regulation of embryonic development	GO:0045995	71	0.068	Mouse
compound eye development	GO:0048749	1	0.068
spinal cord development	GO:0021510	81	0.067
retina development in camera type eye	GO:0060041	119	0.067	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.067
mitral valve development	GO:0003174	4	0.066
asymmetric stem cell division	GO:0098722	3	0.066
cerebral cortex development	GO:0021987	86	0.065
purine ribonucleotide metabolic process	GO:0009150	290	0.065
hormone secretion	GO:0046879	128	0.065
cell maturation	GO:0048469	127	0.065	Mouse
positive regulation of programmed cell death	GO:0043068	218	0.065
regulation of neuron apoptotic process	GO:0043523	122	0.064	Mouse
prostate gland development	GO:0030850	48	0.064
determination of heart left right asymmetry	GO:0061371	48	0.064
axon guidance	GO:0007411	141	0.064
female sex determination	GO:0030237	1	0.063
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.063
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.062
apical junction assembly	GO:0043297	15	0.062
positive regulation of neuron differentiation	GO:0045666	141	0.062
positive regulation of stem cell proliferation	GO:2000648	59	0.061	Mouse
negative regulation of myeloid cell differentiation	GO:0045638	38	0.061
cardiac ventricle morphogenesis	GO:0003208	50	0.061
macromolecule catabolic process	GO:0009057	281	0.060
regulation of gtp catabolic process	GO:0033124	113	0.060
endochondral bone morphogenesis	GO:0060350	50	0.060
developmental programmed cell death	GO:0010623	41	0.060
planar cell polarity pathway involved in pericardium morphogenesis	GO:0061354	2	0.060
hematopoietic progenitor cell differentiation	GO:0002244	143	0.060
regulation of nucleotide catabolic process	GO:0030811	122	0.060
cytoplasmic transport	GO:0016482	234	0.059	Mouse
nucleobase containing small molecule metabolic process	GO:0055086	352	0.059
inner ear receptor cell differentiation	GO:0060113	61	0.059
anatomical structure homeostasis	GO:0060249	145	0.059
olfactory bulb development	GO:0021772	30	0.059
ameboidal type cell migration	GO:0001667	128	0.059
planar cell polarity pathway involved in neural tube closure	GO:0090179	14	0.059
platelet morphogenesis	GO:0036344	13	0.058
erythrocyte differentiation	GO:0030218	88	0.058
cerebellum vasculature morphogenesis	GO:0061301	1	0.058
organonitrogen compound catabolic process	GO:1901565	264	0.058
cell division	GO:0051301	120	0.057
palate development	GO:0060021	76	0.057
hindbrain formation	GO:0021576	1	0.057
regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045898	2	0.057
cerebellum development	GO:0021549	77	0.057
establishment of planar polarity involved in nephron morphogenesis	GO:0072046	1	0.056
chemotaxis	GO:0006935	247	0.056
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.056
stem cell maintenance	GO:0019827	130	0.055	Mouse
positive regulation of homeostatic process	GO:0032846	64	0.055
positive regulation of epithelial cell proliferation involved in lung morphogenesis	GO:0060501	3	0.055
regulation of protein targeting	GO:1903533	61	0.055
wnt signaling pathway involved in kidney development	GO:0061289	2	0.054
regulation of rac gtpase activity	GO:0032314	13	0.054
establishment of planar polarity	GO:0001736	28	0.053
regulation of cellular ketone metabolic process by regulation of transcription from rna polymerase ii promoter	GO:0072364	7	0.053
skeletal muscle fiber development	GO:0048741	58	0.053
negative regulation of execution phase of apoptosis	GO:1900118	4	0.053
positive regulation of transcription from rna polymerase ii promoter involved in heart development	GO:1901228	4	0.053
multi multicellular organism process	GO:0044706	109	0.052
organonitrogen compound biosynthetic process	GO:1901566	192	0.052
regulation of chorionic trophoblast cell proliferation	GO:1901382	1	0.052
negative regulation of bmp signaling pathway	GO:0030514	35	0.052
protein import into nucleus	GO:0006606	95	0.052	Mouse
neuron death	GO:0070997	154	0.052	Mouse
mammary gland epithelium development	GO:0061180	65	0.051
mitotic cell cycle	GO:0000278	195	0.050
cellular chemical homeostasis	GO:0055082	215	0.050
regulation of stem cell maintenance	GO:2000036	17	0.050
gtp catabolic process	GO:0006184	143	0.050
positive regulation of stem cell differentiation	GO:2000738	23	0.050
limb morphogenesis	GO:0035108	149	0.050
canonical wnt signaling pathway	GO:0060070	130	0.049
tube closure	GO:0060606	91	0.049
cochlea development	GO:0090102	35	0.048	Mouse
nucleoside metabolic process	GO:0009116	246	0.048
negative regulation of neuron projection regeneration	GO:0070571	3	0.048
regulation of establishment of protein localization	GO:0070201	181	0.048
lateral inhibition	GO:0046331	1	0.047
positive regulation of mesenchymal cell proliferation	GO:0002053	33	0.047	Mouse
bronchus development	GO:0060433	10	0.047
mechanoreceptor differentiation	GO:0042490	67	0.047
regulation of lymphocyte differentiation	GO:0045619	107	0.047
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.047
learning or memory	GO:0007611	148	0.047
regulation of ras protein signal transduction	GO:0046578	114	0.047
neural crest cell differentiation	GO:0014033	54	0.046
ribonucleoside metabolic process	GO:0009119	245	0.046
actin filament bundle assembly	GO:0051017	40	0.046
cardiac epithelial to mesenchymal transition	GO:0060317	18	0.046
midbrain hindbrain boundary maturation during brain development	GO:0022004	1	0.046
asymmetric neuroblast division	GO:0055059	1	0.045
t cell activation	GO:0042110	289	0.045
non canonical wnt signaling pathway involved in heart development	GO:0061341	3	0.045
oligodendrocyte differentiation	GO:0048709	53	0.045
renal outer medulla development	GO:0072054	2	0.045
negative regulation of catenin import into nucleus	GO:0035414	2	0.045
hematopoietic stem cell differentiation	GO:0060218	8	0.045
cellular response to hormone stimulus	GO:0032870	150	0.044
establishment of organ orientation	GO:0048561	1	0.044
positive regulation of dna templated transcription initiation	GO:2000144	5	0.044
blood circulation	GO:0008015	195	0.044
syncytiotrophoblast cell differentiation involved in labyrinthine layer development	GO:0060715	2	0.044
cardiocyte differentiation	GO:0035051	87	0.044
cell cycle g2 m phase transition	GO:0044839	20	0.044
regulation of cellular component biogenesis	GO:0044087	181	0.044	Mouse
regulation of ovulation	GO:0060278	3	0.044
digestive system development	GO:0055123	200	0.043	Mouse Worm
regulation of cell activation	GO:0050865	289	0.043
sensory perception of mechanical stimulus	GO:0050954	107	0.043	Mouse
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	68	0.043
regionalization	GO:0003002	337	0.043	Mouse
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis	GO:0061350	2	0.043
kidney morphogenesis	GO:0060993	83	0.043	Mouse
cell fate specification	GO:0001708	72	0.042	Mouse Worm
commissural neuron axon guidance	GO:0071679	8	0.042
glomerular mesangial cell development	GO:0072144	3	0.042
regulation of protein localization	GO:0032880	231	0.042	Mouse
cellular response to growth factor stimulus	GO:0071363	197	0.042
guanosine containing compound metabolic process	GO:1901068	144	0.041
lung field specification	GO:0060424	3	0.041
stem cell division	GO:0017145	30	0.041
positive regulation of gtpase activity	GO:0043547	85	0.041
response to organonitrogen compound	GO:0010243	246	0.041
astrocyte fate commitment	GO:0060018	4	0.040
mesonephric duct formation	GO:0072181	2	0.040
purine ribonucleoside metabolic process	GO:0046128	241	0.040
lateral sprouting involved in mammary gland duct morphogenesis	GO:0060599	2	0.040
t cell selection	GO:0045058	34	0.040
peptide secretion	GO:0002790	114	0.040
bone marrow development	GO:0048539	3	0.040
regulation of cardioblast differentiation	GO:0051890	3	0.040
lymphocyte activation involved in immune response	GO:0002285	93	0.040
glandular epithelial cell differentiation	GO:0002067	38	0.040
regulation of retina development in camera type eye	GO:1902866	3	0.039	Mouse
regulation of myeloid cell differentiation	GO:0045637	96	0.039
sequestering of metal ion	GO:0051238	19	0.039
compartment pattern specification	GO:0007386	4	0.039
lung cell differentiation	GO:0060479	30	0.039
cell surface receptor signaling pathway involved in heart development	GO:0061311	15	0.039
cell cell signaling involved in cell fate commitment	GO:0045168	35	0.039	Mouse
immune effector process	GO:0002252	321	0.039
positive regulation of long term neuronal synaptic plasticity	GO:0048170	3	0.039
sensory perception of sound	GO:0007605	97	0.039	Mouse
peptide transport	GO:0015833	133	0.039
regulation of canonical wnt signaling pathway involved in controlling type b pancreatic cell proliferation	GO:2000079	1	0.039
mesonephric tubule formation	GO:0072172	11	0.039	Mouse
purine nucleoside metabolic process	GO:0042278	241	0.039
cd4 positive alpha beta t cell differentiation involved in immune response	GO:0002294	28	0.039
positive regulation of hydrolase activity	GO:0051345	148	0.039
negative regulation of glial cell proliferation	GO:0060253	4	0.038
cerebellar cortex development	GO:0021695	48	0.038
positive regulation of mesonephros development	GO:0061213	20	0.038	Mouse
cell substrate adhesion	GO:0031589	130	0.038
fasciculation of motor neuron axon	GO:0097156	2	0.038
forebrain regionalization	GO:0021871	25	0.038	Mouse
positive regulation of cytosolic calcium ion concentration	GO:0007204	65	0.037
myotube differentiation	GO:0014902	105	0.037	Mouse Fly
cellular response to organonitrogen compound	GO:0071417	145	0.037
hypophysis morphogenesis	GO:0048850	3	0.037
carbohydrate homeostasis	GO:0033500	128	0.037
regulation of intracellular protein transport	GO:0033157	82	0.037
development of primary sexual characteristics	GO:0045137	143	0.037	Mouse Fly
mitotic cell cycle process	GO:1903047	159	0.037
peptidyl tyrosine modification	GO:0018212	145	0.037
meiotic cell cycle	GO:0051321	122	0.037
blood coagulation	GO:0007596	76	0.037
negative regulation of mesenchymal cell proliferation	GO:0072201	3	0.036
endocardial cell differentiation	GO:0060956	4	0.036
cell differentiation in spinal cord	GO:0021515	53	0.036
ventral midline development	GO:0007418	4	0.036
head morphogenesis	GO:0060323	34	0.036
midbrain hindbrain boundary maturation	GO:0021732	1	0.036
cell aging	GO:0007569	35	0.036
macromolecule methylation	GO:0043414	120	0.036
apoptotic process involved in morphogenesis	GO:0060561	25	0.035
cellular response to lipid	GO:0071396	145	0.035
nucleoside phosphate metabolic process	GO:0006753	338	0.035
regulation of myeloid leukocyte differentiation	GO:0002761	58	0.035
regulation of protein serine threonine kinase activity	GO:0071900	157	0.035
platelet formation	GO:0030220	12	0.035
regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	GO:2000702	1	0.035
positive regulation of neuron apoptotic process	GO:0043525	25	0.035
skin morphogenesis	GO:0043589	38	0.035
mesenchymal cell development	GO:0014031	93	0.035
regulation of cell fate commitment	GO:0010453	19	0.035
embryonic placenta development	GO:0001892	98	0.035
multicellular organismal reproductive behavior	GO:0033057	23	0.035
cardiac septum morphogenesis	GO:0060411	46	0.035
response to growth factor	GO:0070848	198	0.034
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.034
cardiac septum development	GO:0003279	59	0.034
canonical wnt signaling pathway involved in regulation of cell proliferation	GO:0044340	3	0.034
coagulation	GO:0050817	78	0.034
methylation	GO:0032259	134	0.034
cytokine production	GO:0001816	319	0.034
hindbrain morphogenesis	GO:0021575	46	0.034
cation transmembrane transport	GO:0098655	266	0.034
platelet activation	GO:0030168	40	0.033
protein localization to nucleus	GO:0034504	121	0.033	Mouse
regulation of protein import into nucleus	GO:0042306	52	0.033
calcium ion homeostasis	GO:0055074	127	0.033
polarity specification of proximal distal axis	GO:0010085	2	0.033
positive regulation of protein kinase activity	GO:0045860	144	0.033
negative regulation of fat cell differentiation	GO:0045599	36	0.033
morphogenesis of a polarized epithelium	GO:0001738	37	0.033
blastocyst formation	GO:0001825	33	0.032
regulation of endopeptidase activity	GO:0052548	89	0.032
cardiac muscle cell myoblast differentiation	GO:0060379	8	0.032
nephron tubule development	GO:0072080	84	0.032	Mouse
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	GO:0060528	4	0.032
planar cell polarity pathway involved in heart morphogenesis	GO:0061346	3	0.032
positive regulation of protein transport	GO:0051222	93	0.032
regulation of osteoblast differentiation	GO:0045667	67	0.032
synapse organization	GO:0050808	125	0.032	Mouse
coronary vasculature development	GO:0060976	12	0.032
purine ribonucleotide catabolic process	GO:0009154	208	0.032
arterial endothelial cell differentiation	GO:0060842	5	0.031
muscle cell fate specification	GO:0042694	1	0.031
positive regulation of cellular catabolic process	GO:0031331	148	0.031
protein modification by small protein conjugation or removal	GO:0070647	207	0.031
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.031
definitive hemopoiesis	GO:0060216	20	0.031
regulation of cell cycle process	GO:0010564	160	0.031	Mouse
regulation of binding	GO:0051098	111	0.031
epithelial cell proliferation	GO:0050673	174	0.031	Mouse
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.031
cell cell junction assembly	GO:0007043	27	0.031
glucose homeostasis	GO:0042593	128	0.031
positive regulation of fibroblast growth factor receptor signaling pathway	GO:0045743	3	0.031
inner ear receptor cell development	GO:0060119	39	0.030
cellular ion homeostasis	GO:0006873	165	0.030
hemostasis	GO:0007599	78	0.030
axis elongation involved in somitogenesis	GO:0090245	4	0.030
modification dependent macromolecule catabolic process	GO:0043632	133	0.030
regulation of proteolysis	GO:0030162	164	0.030
elastic fiber assembly	GO:0048251	4	0.030
negative regulation of cartilage development	GO:0061037	17	0.030
cellular metal ion homeostasis	GO:0006875	151	0.030
cerebellum morphogenesis	GO:0021587	42	0.030
leukocyte activation involved in immune response	GO:0002366	126	0.030
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.030
wnt signaling pathway involved in somitogenesis	GO:0090244	4	0.030
regulation of hormone secretion	GO:0046883	88	0.030
myeloid cell homeostasis	GO:0002262	114	0.030
transcription initiation from rna polymerase ii promoter	GO:0006367	8	0.030
dna replication	GO:0006260	52	0.030
regulation of epithelial cell proliferation	GO:0050678	141	0.029	Mouse

Six5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.053
disease of anatomical entity	DOID:7	0.046
musculoskeletal system disease	DOID:17	0.046

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