IMP: Integrative Multi-species Prediction

Mus musculus

235 known processes

Six2

sine oculis-related homeobox 2 homolog (Drosophila)

Ensembl: ENSMUSG00000024134
Entrez: 20472
UniProtKB: Q62232

Process Predictions
Disease Predictions

Six2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
skeletal system development	GO:0001501	356	0.933
skeletal system morphogenesis	GO:0048705	203	0.883
forebrain development	GO:0030900	302	0.883	Mouse
cartilage development	GO:0051216	140	0.879
regionalization	GO:0003002	337	0.877
positive regulation of secondary heart field cardioblast proliferation	GO:0072513	4	0.875	Mouse
diencephalon development	GO:0021536	63	0.871	Mouse
mesoderm development	GO:0007498	100	0.868
stem cell differentiation	GO:0048863	268	0.852
central nervous system neuron differentiation	GO:0021953	162	0.808
digestive tract development	GO:0048565	190	0.799
kidney epithelium development	GO:0072073	121	0.756
embryonic organ morphogenesis	GO:0048562	276	0.750
embryonic skeletal system morphogenesis	GO:0048704	91	0.722
sensory organ morphogenesis	GO:0090596	242	0.713
positive regulation of cell development	GO:0010720	237	0.709
connective tissue development	GO:0061448	179	0.684
cell differentiation in spinal cord	GO:0021515	53	0.684
regulation of organ morphogenesis	GO:2000027	144	0.678
lymphocyte differentiation	GO:0030098	242	0.675
ventral spinal cord interneuron differentiation	GO:0021514	16	0.670
striated muscle tissue development	GO:0014706	293	0.659	Mouse
carbon catabolite repression of transcription from rna polymerase ii promoter	GO:0000437	1	0.652
embryonic skeletal system development	GO:0048706	120	0.642
stem cell development	GO:0048864	219	0.640
mesenchymal cell differentiation	GO:0048762	107	0.617
regulation of neuron differentiation	GO:0045664	281	0.608	Mouse
t cell differentiation	GO:0030217	174	0.599
spinal cord development	GO:0021510	81	0.597
positive regulation of neuron differentiation	GO:0045666	141	0.577
negative regulation of cell proliferation	GO:0008285	296	0.570	Mouse
neuron fate specification	GO:0048665	30	0.567	Mouse
stem cell maintenance	GO:0019827	130	0.563
carbon catabolite activation of transcription from rna polymerase ii promoter	GO:0000436	4	0.559
gland development	GO:0048732	330	0.559	Mouse Fly
cell fate commitment	GO:0045165	210	0.551
neuron projection guidance	GO:0097485	141	0.538
forebrain generation of neurons	GO:0021872	63	0.533
mesenchymal cell development	GO:0014031	93	0.527
negative regulation of nervous system development	GO:0051961	156	0.524	Mouse
epidermis development	GO:0008544	187	0.521
nephron tubule morphogenesis	GO:0072078	68	0.511
paraxial mesodermal cell fate commitment	GO:0048343	2	0.510
subpallium neuron fate commitment	GO:0060163	2	0.508
muscle tissue development	GO:0060537	308	0.505	Mouse
digestive system development	GO:0055123	200	0.491
blood vessel morphogenesis	GO:0048514	285	0.484	Mouse
neural tube formation	GO:0001841	108	0.467
negative regulation of neuron differentiation	GO:0045665	101	0.461	Mouse
limb morphogenesis	GO:0035108	149	0.456
mesonephric tubule development	GO:0072164	94	0.447
ureteric bud development	GO:0001657	94	0.435
pyramidal neuron migration	GO:0021852	1	0.429
negative regulation of cell development	GO:0010721	169	0.426	Mouse
paraxial mesodermal cell differentiation	GO:0048342	2	0.425
nephron epithelium morphogenesis	GO:0072088	68	0.424
t cell activation	GO:0042110	289	0.414
male gamete generation	GO:0048232	285	0.413	Mouse Fly
appendage development	GO:0048736	166	0.408
cell fate specification	GO:0001708	72	0.405
mesenchyme development	GO:0060485	152	0.399
regulation of cell cycle	GO:0051726	281	0.391	Mouse
respiratory system development	GO:0060541	190	0.390	Mouse
somitogenesis	GO:0001756	69	0.374
ureteric bud morphogenesis	GO:0060675	62	0.373
appendage morphogenesis	GO:0035107	149	0.367
inner ear morphogenesis	GO:0042472	101	0.364	Mouse
auditory receptor cell fate determination	GO:0042668	3	0.361
dendrite development	GO:0016358	115	0.356
neural crest cell differentiation	GO:0014033	54	0.355
regulation of ureteric bud formation	GO:0072106	3	0.352	Mouse
nephron epithelium development	GO:0072009	92	0.349
ear development	GO:0043583	200	0.347
positive regulation of glial cell proliferation	GO:0060252	4	0.342
cardiac chamber morphogenesis	GO:0003206	93	0.342
tube formation	GO:0035148	140	0.332	Mouse
axon guidance	GO:0007411	141	0.332
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	GO:0072108	3	0.328
forebrain neuron differentiation	GO:0021879	52	0.322
germ cell development	GO:0007281	185	0.322	Mouse
endocardial cushion to mesenchymal transition involved in heart valve formation	GO:0003199	4	0.319
camera type eye development	GO:0043010	266	0.319	Mouse
neural tube development	GO:0021915	160	0.318
mesonephric tubule morphogenesis	GO:0072171	63	0.315
lung development	GO:0030324	164	0.307
nephron morphogenesis	GO:0072028	69	0.307
hindbrain development	GO:0030902	128	0.306
cell adhesion	GO:0007155	329	0.305
leukocyte differentiation	GO:0002521	342	0.300
neuron migration	GO:0001764	122	0.298
regulation of retina development in camera type eye	GO:1902866	3	0.297	Mouse
muscle cell differentiation	GO:0042692	261	0.296	Mouse
regulation of bmp signaling pathway	GO:0030510	60	0.293
regulation of cell adhesion	GO:0030155	154	0.292
spermatogenesis	GO:0007283	284	0.290	Mouse Fly
digestive tract morphogenesis	GO:0048546	147	0.289
axonogenesis	GO:0007409	274	0.283
central nervous system neuron development	GO:0021954	67	0.283
morphogenesis of a branching structure	GO:0001763	203	0.281
forebrain neuron fate commitment	GO:0021877	13	0.281
skin development	GO:0043588	220	0.277
regulation of chondrocyte differentiation	GO:0032330	33	0.277
ear morphogenesis	GO:0042471	118	0.277
regulation of stem cell differentiation	GO:2000736	50	0.276	Mouse
cerebral cortex neuron differentiation	GO:0021895	19	0.275
neural crest cell development	GO:0014032	48	0.275
myotube differentiation	GO:0014902	105	0.274	Mouse
neural tube closure	GO:0001843	90	0.273
ventral spinal cord interneuron fate commitment	GO:0060579	14	0.260
nephron development	GO:0072006	109	0.260
chondrocyte differentiation	GO:0002062	72	0.255
telencephalon development	GO:0021537	186	0.255	Mouse
mesoderm morphogenesis	GO:0048332	64	0.246
regulation of heart morphogenesis	GO:2000826	22	0.246	Mouse
pituitary gland development	GO:0021983	38	0.245	Mouse
kidney morphogenesis	GO:0060993	83	0.240
ventricular cardiac muscle tissue morphogenesis	GO:0055010	32	0.237
gliogenesis	GO:0042063	141	0.227	Fly
trachea cartilage morphogenesis	GO:0060535	4	0.226
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation	GO:0003257	3	0.225
regulation of stem cell proliferation	GO:0072091	78	0.222	Mouse
heart morphogenesis	GO:0003007	178	0.221	Mouse
outflow tract morphogenesis	GO:0003151	53	0.218	Mouse
somite development	GO:0061053	81	0.217	Mouse
positive regulation of mitochondrial membrane permeability involved in apoptotic process	GO:1902110	11	0.216
epithelial cell proliferation	GO:0050673	174	0.213	Mouse
regulation of neuron projection development	GO:0010975	169	0.212
mesodermal cell fate specification	GO:0007501	11	0.211
apoptotic signaling pathway	GO:0097190	306	0.210
embryonic heart tube morphogenesis	GO:0003143	51	0.209
metanephros development	GO:0001656	79	0.208
embryonic eye morphogenesis	GO:0048048	29	0.208	Mouse
tongue development	GO:0043586	18	0.202	Mouse
extracellular structure organization	GO:0043062	148	0.201
ectoderm formation	GO:0001705	3	0.200
morphogenesis of a branching epithelium	GO:0061138	193	0.200
cell fate specification involved in pattern specification	GO:0060573	11	0.200
mesodermal cell differentiation	GO:0048333	22	0.199
positive regulation of transcription from rna polymerase ii promoter by glucose	GO:0000432	3	0.196
limb development	GO:0060173	166	0.196
positive regulation of nervous system development	GO:0051962	221	0.196
cardiac muscle tissue morphogenesis	GO:0055008	44	0.190
glial cell differentiation	GO:0010001	131	0.189
skeletal muscle cell differentiation	GO:0035914	66	0.188	Mouse
oligodendrocyte differentiation	GO:0048709	53	0.185
chemotaxis	GO:0006935	247	0.184
cardiac neural crest cell migration involved in outflow tract morphogenesis	GO:0003253	3	0.182
regulation of neuroblast proliferation	GO:1902692	27	0.181	Mouse
olfactory bulb development	GO:0021772	30	0.181
ventral spinal cord development	GO:0021517	48	0.181
embryonic epithelial tube formation	GO:0001838	130	0.180	Mouse
cranial nerve morphogenesis	GO:0021602	26	0.179	Mouse
nephric duct formation	GO:0072179	4	0.179
histone modification	GO:0016570	159	0.177
astrocyte fate commitment	GO:0060018	4	0.176
regulation of myotube differentiation	GO:0010830	62	0.175
pharynx development	GO:0060465	1	0.174
ventricular cardiac muscle tissue development	GO:0003229	38	0.174
developmental maturation	GO:0021700	193	0.171	Mouse
cardiac chamber development	GO:0003205	108	0.171
limbic system development	GO:0021761	72	0.169
positive regulation of inner ear receptor cell differentiation	GO:2000982	1	0.169
metanephric nephron morphogenesis	GO:0072273	19	0.168
ossification	GO:0001503	216	0.167
regulation of homeostatic process	GO:0032844	182	0.167
spinal cord association neuron differentiation	GO:0021527	14	0.165
kidney development	GO:0001822	213	0.165
cardiac epithelial to mesenchymal transition	GO:0060317	18	0.162
urogenital system development	GO:0001655	261	0.161
bmp signaling pathway	GO:0030509	93	0.161
multicellular organismal homeostasis	GO:0048871	164	0.161
epithelial tube formation	GO:0072175	130	0.160	Mouse
endocrine system development	GO:0035270	98	0.159	Mouse Fly
hindbrain morphogenesis	GO:0021575	46	0.159
bone morphogenesis	GO:0060349	78	0.159
lung cell differentiation	GO:0060479	30	0.158
regulation of auditory receptor cell differentiation	GO:0045607	4	0.157
primary neural tube formation	GO:0014020	95	0.155
myeloid cell differentiation	GO:0030099	233	0.154
embryonic heart tube development	GO:0035050	65	0.154
alpha beta t cell differentiation	GO:0046632	69	0.153
trophectodermal cell differentiation	GO:0001829	21	0.151
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	GO:2000802	1	0.149
epithelial tube morphogenesis	GO:0060562	303	0.149
myeloid leukocyte differentiation	GO:0002573	119	0.147
positive regulation of ureteric bud formation	GO:0072107	3	0.145	Mouse
pallium development	GO:0021543	120	0.144
cell fate determination	GO:0001709	32	0.144
regulation of nephron tubule epithelial cell differentiation	GO:0072182	9	0.143
regulation of cellular amino acid metabolic process	GO:0006521	5	0.143
positive regulation of auditory receptor cell differentiation	GO:0045609	1	0.143
lung epithelial cell differentiation	GO:0060487	29	0.142
alpha beta t cell activation	GO:0046631	91	0.142
regulation of leukocyte differentiation	GO:1902105	159	0.141
spermatid differentiation	GO:0048515	115	0.141	Mouse
peptidyl amino acid modification	GO:0018193	336	0.140
midbrain development	GO:0030901	35	0.139
notch signaling pathway	GO:0007219	71	0.139
regulation of cellular amine metabolic process	GO:0033238	20	0.139
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	GO:2000800	1	0.138
spinal cord dorsal ventral patterning	GO:0021513	23	0.138
metanephric capsule specification	GO:0072267	1	0.137
aorta development	GO:0035904	23	0.137	Mouse
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.137
notochord development	GO:0030903	20	0.136
forebrain morphogenesis	GO:0048853	17	0.135
regulation of transferase activity	GO:0051338	263	0.135
metanephric nephron tubule formation	GO:0072289	4	0.134
epithelial cell development	GO:0002064	159	0.133
segmentation	GO:0035282	93	0.133
amine metabolic process	GO:0009308	45	0.133
muscle cell development	GO:0055001	133	0.132	Mouse
mitral valve development	GO:0003174	4	0.132
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.132
cell fate commitment involved in pattern specification	GO:0060581	14	0.130
sensory perception of sound	GO:0007605	97	0.129	Mouse
epithelial cell fate commitment	GO:0072148	13	0.128
somatotropin secreting cell differentiation	GO:0060126	4	0.128
regulation of cell proliferation involved in heart morphogenesis	GO:2000136	15	0.127	Mouse
somatic stem cell maintenance	GO:0035019	47	0.127
cardiocyte differentiation	GO:0035051	87	0.127
cell maturation	GO:0048469	127	0.126	Mouse
somatic sex determination	GO:0018993	2	0.126
cytokine production	GO:0001816	319	0.125
cerebral cortex development	GO:0021987	86	0.124
primitive streak formation	GO:0090009	10	0.124
nephron tubule epithelial cell differentiation	GO:0072160	11	0.123
visceral motor neuron differentiation	GO:0021524	3	0.123
neuroblast differentiation	GO:0014016	2	0.123	Mouse
peripheral nervous system neuron axonogenesis	GO:0048936	3	0.123
muscle tissue morphogenesis	GO:0060415	53	0.123
blastocyst formation	GO:0001825	33	0.123
formation of primary germ layer	GO:0001704	77	0.122
b cell activation	GO:0042113	161	0.122
renal system development	GO:0072001	225	0.122
endodermal cell fate specification	GO:0001714	4	0.120
regulation of secondary heart field cardioblast proliferation	GO:0003266	9	0.120	Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.119
cell proliferation involved in outflow tract morphogenesis	GO:0061325	4	0.119
regulation of epithelial cell proliferation	GO:0050678	141	0.119	Mouse
hindbrain formation	GO:0021576	1	0.118
embryonic placenta development	GO:0001892	98	0.118
regulation of glial cell differentiation	GO:0045685	41	0.117
metanephric nephron tubule epithelial cell differentiation	GO:0072257	5	0.117
regulation of cell cycle process	GO:0010564	160	0.117	Mouse
kidney rudiment formation	GO:0072003	3	0.117
gastrulation	GO:0007369	116	0.116
positive regulation of lymphocyte activation	GO:0051251	140	0.115
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.115
embryonic camera type eye development	GO:0031076	36	0.115	Mouse
lung epithelium development	GO:0060428	37	0.115
mesenchymal cell proliferation	GO:0010463	44	0.115	Mouse
wnt signaling pathway involved in forebrain neuroblast division	GO:0021874	2	0.114
cellular homeostasis	GO:0019725	240	0.114
carbon catabolite activation of transcription	GO:0045991	4	0.113
central nervous system vasculogenesis	GO:0022009	3	0.112
regulation of lymphocyte activation	GO:0051249	240	0.112
positive regulation of mesenchymal cell proliferation involved in ureter development	GO:2000729	3	0.112	Mouse
negative regulation of neuron projection development	GO:0010977	50	0.111
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045899	2	0.111
positive regulation of cellular amine metabolic process	GO:0033240	5	0.110
pericardium development	GO:0060039	16	0.110
response to growth factor	GO:0070848	198	0.110
skeletal muscle organ development	GO:0060538	163	0.109	Mouse
regulation of gliogenesis	GO:0014013	50	0.109
epithelial to mesenchymal transition	GO:0001837	47	0.108
regulation of transcription from rna polymerase ii promoter involved in ventral spinal cord interneuron specification	GO:0021913	4	0.107
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process	GO:2000763	1	0.107
cerebellum formation	GO:0021588	1	0.107
prostate gland stromal morphogenesis	GO:0060741	2	0.106
mesodermal cell fate commitment	GO:0001710	17	0.105
stem cell proliferation	GO:0072089	117	0.105
regulation of system process	GO:0044057	200	0.105
single organismal cell cell adhesion	GO:0016337	131	0.104
cellular response to retinoic acid	GO:0071300	25	0.103
regulation of t cell differentiation	GO:0045580	83	0.103
positive regulation of transcription from rna polymerase ii promoter involved in heart development	GO:1901228	4	0.103
negative regulation of apoptotic process involved in outflow tract morphogenesis	GO:1902257	2	0.103
jak stat cascade	GO:0007259	42	0.101
carbon catabolite regulation of transcription from rna polymerase ii promoter	GO:0000429	4	0.101
regulation of cartilage development	GO:0061035	44	0.100
positive regulation of epithelial cell proliferation involved in lung morphogenesis	GO:0060501	3	0.100
negative regulation of fat cell differentiation	GO:0045599	36	0.099
regulation of kidney development	GO:0090183	40	0.099
compound eye development	GO:0048749	1	0.099	Fly
ameboidal type cell migration	GO:0001667	128	0.098
pancreatic pp cell fate commitment	GO:0003329	2	0.098
cell proliferation involved in heart morphogenesis	GO:0061323	15	0.098	Mouse
positive regulation of gliogenesis	GO:0014015	27	0.097
hair cell differentiation	GO:0035315	40	0.096
cell fate commitment involved in formation of primary germ layer	GO:0060795	26	0.096
pattern specification involved in metanephros development	GO:0072268	4	0.096
mitochondrial outer membrane permeabilization involved in programmed cell death	GO:1902686	11	0.096
tendon cell differentiation	GO:0035990	4	0.095
brain morphogenesis	GO:0048854	32	0.095
cardiac muscle tissue development	GO:0048738	130	0.095
blastocyst development	GO:0001824	80	0.095
pancreatic a cell fate commitment	GO:0003326	2	0.095
specification of organ position	GO:0010159	3	0.094
bone development	GO:0060348	120	0.093
commitment of neuronal cell to specific neuron type in forebrain	GO:0021902	7	0.093
mesoderm formation	GO:0001707	62	0.093
body morphogenesis	GO:0010171	45	0.093
positive regulation of protein phosphorylation	GO:0001934	242	0.092
midbrain hindbrain boundary maturation	GO:0021732	1	0.092
syncytium formation by plasma membrane fusion	GO:0000768	42	0.091
locomotory behavior	GO:0007626	195	0.091
forebrain regionalization	GO:0021871	25	0.091	Mouse
regulation of t cell activation	GO:0050863	170	0.091
mesenchyme morphogenesis	GO:0072132	32	0.090
mesonephros development	GO:0001823	97	0.090
neuron fate determination	GO:0048664	9	0.090
aortic valve morphogenesis	GO:0003180	4	0.090
nephrogenic mesenchyme development	GO:0072076	3	0.089
negative regulation of intracellular signal transduction	GO:1902532	167	0.089
apoptotic process involved in outflow tract morphogenesis	GO:0003275	2	0.088
embryonic digestive tract morphogenesis	GO:0048557	17	0.088
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.088
regulation of organ formation	GO:0003156	34	0.087	Mouse
cell differentiation involved in kidney development	GO:0061005	33	0.087
carbohydrate homeostasis	GO:0033500	128	0.087
optic nerve development	GO:0021554	8	0.086
trabecula morphogenesis	GO:0061383	40	0.085
mitotic cell cycle	GO:0000278	195	0.084
respiratory tube development	GO:0030323	167	0.084
negative regulation of cell fate specification	GO:0009996	4	0.084
rhombomere development	GO:0021546	8	0.084
autonomic nervous system development	GO:0048483	43	0.084	Mouse
cochlea morphogenesis	GO:0090103	22	0.083	Mouse
mesodermal to mesenchymal transition involved in gastrulation	GO:0060809	1	0.083
palate development	GO:0060021	76	0.083
histone acetylation	GO:0016573	41	0.082
ras protein signal transduction	GO:0007265	77	0.081
regulation of membrane permeability	GO:0090559	18	0.080
nephron tubule formation	GO:0072079	20	0.080	Mouse
multicellular organism growth	GO:0035264	161	0.080
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.080
lung induction	GO:0060492	3	0.079
cell proliferation in hindbrain	GO:0021534	10	0.079
positive regulation of transcription by glucose	GO:0046016	3	0.079
regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis	GO:0072039	4	0.079
renal tubule development	GO:0061326	87	0.079
regulation of stem cell maintenance	GO:2000036	17	0.078
hypothalamus development	GO:0021854	16	0.078
positive regulation of keratinocyte proliferation	GO:0010838	4	0.078
mammary gland epithelium development	GO:0061180	65	0.078
cardiac ventricle morphogenesis	GO:0003208	50	0.078
regulation of epithelial cell differentiation involved in kidney development	GO:2000696	10	0.078
cardiac septum morphogenesis	GO:0060411	46	0.078
regulation of cellular ketone metabolic process	GO:0010565	66	0.078
hypophysis morphogenesis	GO:0048850	3	0.078
myeloid cell homeostasis	GO:0002262	114	0.077
branching involved in ureteric bud morphogenesis	GO:0001658	56	0.077
covalent chromatin modification	GO:0016569	163	0.076
aorta morphogenesis	GO:0035909	22	0.076	Mouse
regulation of fat cell differentiation	GO:0045598	81	0.075
positive regulation of cell cycle	GO:0045787	92	0.075
regulation of protein kinase activity	GO:0045859	232	0.075
metencephalon development	GO:0022037	89	0.074
response to acid chemical	GO:0001101	111	0.074
regulation of epithelial to mesenchymal transition	GO:0010717	22	0.074
organelle fission	GO:0048285	170	0.074
mesenchymal stem cell maintenance involved in nephron morphogenesis	GO:0072038	7	0.073
paramesonephric duct development	GO:0061205	3	0.073
positive regulation of cell death	GO:0010942	224	0.073
forebrain cell migration	GO:0021885	58	0.072
regulation of apoptotic signaling pathway	GO:2001233	197	0.072
regulation of cell migration	GO:0030334	219	0.072
positive regulation of leukocyte differentiation	GO:1902107	86	0.072
renal vesicle induction	GO:0072034	3	0.071
cell migration involved in gastrulation	GO:0042074	13	0.071
endocardial cushion morphogenesis	GO:0003203	18	0.071
somite rostral caudal axis specification	GO:0032525	13	0.070
middle ear morphogenesis	GO:0042474	23	0.070
tongue morphogenesis	GO:0043587	8	0.069	Mouse
detection of monosaccharide stimulus	GO:0034287	1	0.069
microtubule cytoskeleton organization	GO:0000226	157	0.069
endothelium development	GO:0003158	45	0.069
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	GO:0060528	4	0.068
olfactory lobe development	GO:0021988	32	0.068
lateral sprouting involved in mammary gland duct morphogenesis	GO:0060599	2	0.067
osteoclast differentiation	GO:0030316	62	0.067
negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis	GO:0072040	4	0.067
peptidyl tyrosine phosphorylation	GO:0018108	143	0.067
cardiac ventricle development	GO:0003231	83	0.067
metanephric tubule development	GO:0072170	18	0.066
positive regulation of stem cell proliferation	GO:2000648	59	0.066	Mouse
regulation of neuron migration	GO:2001222	22	0.066
paraxial mesoderm development	GO:0048339	18	0.066
positive regulation of apoptotic process	GO:0043065	217	0.066
protein localization to organelle	GO:0033365	185	0.066
negative regulation of gliogenesis	GO:0014014	23	0.066
cell differentiation in hindbrain	GO:0021533	24	0.065
endoderm formation	GO:0001706	20	0.065
regulation of neuron death	GO:1901214	134	0.065	Mouse
regulation of cell activation	GO:0050865	289	0.065
regulation of cardiac muscle tissue growth	GO:0055021	26	0.065
cytoplasmic transport	GO:0016482	234	0.065
regulation of muscle tissue development	GO:1901861	97	0.065	Mouse
regulation of lymphocyte proliferation	GO:0050670	117	0.065
mesangial cell differentiation	GO:0072007	4	0.065
thymus development	GO:0048538	41	0.064	Mouse
regulation of histone modification	GO:0031056	56	0.064
retina development in camera type eye	GO:0060041	119	0.064	Mouse
positive regulation of myeloid cell differentiation	GO:0045639	43	0.064
kidney mesenchyme development	GO:0072074	14	0.064
dorsal spinal cord development	GO:0021516	20	0.064
lateral motor column neuron migration	GO:0097477	3	0.064
atrioventricular valve morphogenesis	GO:0003181	13	0.064
negative regulation of cell activation	GO:0050866	111	0.064
apoptotic process involved in morphogenesis	GO:0060561	25	0.064
positive regulation of t cell differentiation	GO:0045582	52	0.063
odontogenesis of dentin containing tooth	GO:0042475	66	0.063
mesenchymal cell proliferation involved in ureter development	GO:0072198	4	0.062	Mouse
glossopharyngeal nerve morphogenesis	GO:0021615	4	0.062
pattern specification involved in kidney development	GO:0061004	8	0.062
tendon formation	GO:0035992	4	0.061
intestinal epithelial cell maturation	GO:0060574	2	0.061
embryonic viscerocranium morphogenesis	GO:0048703	8	0.061
regulation of cardioblast differentiation	GO:0051890	3	0.061
morphogenesis of embryonic epithelium	GO:0016331	159	0.060	Mouse
establishment of organ orientation	GO:0048561	1	0.060
rhombomere morphogenesis	GO:0021593	2	0.060
positive regulation of t cell activation	GO:0050870	101	0.060
rhombomere 3 morphogenesis	GO:0021658	2	0.060
cell division	GO:0051301	120	0.060
protein modification by small protein conjugation	GO:0032446	187	0.060
polarity specification of proximal distal axis	GO:0010085	2	0.060
auditory receptor cell fate specification	GO:0042667	1	0.060
cardiac septum development	GO:0003279	59	0.060
regulation of binding	GO:0051098	111	0.060
regulation of skeletal muscle fiber differentiation	GO:1902809	3	0.059
mesenchymal to epithelial transition	GO:0060231	12	0.059
cellular chemical homeostasis	GO:0055082	215	0.059
lateral line system development	GO:0048925	1	0.059
face morphogenesis	GO:0060325	29	0.059
divalent inorganic cation homeostasis	GO:0072507	138	0.059
semaphorin plexin signaling pathway involved in outflow tract morphogenesis	GO:0071527	1	0.058
planar cell polarity pathway involved in pericardium morphogenesis	GO:0061354	2	0.058
cellular response to glucose stimulus	GO:0071333	45	0.058
positive regulation of mapk cascade	GO:0043410	170	0.058
cellular ketone metabolic process	GO:0042180	84	0.057
sperm motility	GO:0030317	47	0.057
cellular amine metabolic process	GO:0044106	44	0.057
axial mesoderm formation	GO:0048320	3	0.057
biomineral tissue development	GO:0031214	64	0.056
determination of left right symmetry	GO:0007368	80	0.056
cell type specific apoptotic process	GO:0097285	268	0.056	Mouse
epithelial cell differentiation involved in mammary gland alveolus development	GO:0061030	4	0.056
regulation of astrocyte differentiation	GO:0048710	20	0.056
rhombomere formation	GO:0021594	1	0.056
syncytium formation	GO:0006949	43	0.055
head morphogenesis	GO:0060323	34	0.055
dentate gyrus development	GO:0021542	14	0.054
establishment of planar polarity involved in nephron morphogenesis	GO:0072046	1	0.054
segment specification	GO:0007379	15	0.054
neural crest cell migration	GO:0001755	32	0.054
vagus nerve development	GO:0021564	3	0.054
regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045898	2	0.054
regulation of mesenchymal cell proliferation involved in ureter development	GO:0072199	3	0.054	Mouse
forelimb morphogenesis	GO:0035136	40	0.053
peripheral nervous system development	GO:0007422	53	0.053
positive regulation of neuroblast proliferation	GO:0002052	19	0.053
artery development	GO:0060840	53	0.053	Mouse
epithelial mesenchymal signaling involved in prostate gland development	GO:0060738	2	0.053
mitral valve morphogenesis	GO:0003183	4	0.053
skin morphogenesis	GO:0043589	38	0.053
positive regulation of cell activation	GO:0050867	158	0.053
forebrain neuron development	GO:0021884	30	0.053
respiratory gaseous exchange	GO:0007585	43	0.052
regulation of striated muscle cell differentiation	GO:0051153	81	0.052
extraocular skeletal muscle development	GO:0002074	2	0.052
t cell differentiation in thymus	GO:0033077	77	0.052
sclerotome development	GO:0061056	4	0.052
epithelial cell differentiation involved in kidney development	GO:0035850	23	0.052
dorsal ventral neural tube patterning	GO:0021904	28	0.051
otic vesicle development	GO:0071599	14	0.051	Mouse
determination of heart left right asymmetry	GO:0061371	48	0.051
nephron tubule development	GO:0072080	84	0.051
specification of loop of henle identity	GO:0072086	4	0.051
regulation of lymphocyte differentiation	GO:0045619	107	0.051
b cell differentiation	GO:0030183	78	0.051
gonad development	GO:0008406	141	0.051	Mouse
cardiac muscle cell differentiation	GO:0055007	69	0.050
mammary gland epithelial cell proliferation	GO:0033598	24	0.050
cd4 positive alpha beta t cell activation	GO:0035710	45	0.050
circadian rhythm	GO:0007623	114	0.050	Mouse Fly
regulation of neural retina development	GO:0061074	3	0.050	Mouse
glomerular mesangial cell development	GO:0072144	3	0.050
positive regulation of skeletal muscle fiber development	GO:0048743	3	0.050
regulation of cardiac chamber formation	GO:1901210	1	0.050
renal capsule formation	GO:0072129	1	0.049
cardioblast proliferation	GO:0003263	8	0.049	Mouse
mesenchymal to epithelial transition involved in metanephros morphogenesis	GO:0003337	9	0.049
mesonephric epithelium development	GO:0072163	94	0.049
intrinsic apoptotic signaling pathway	GO:0097193	132	0.049
negative regulation of molecular function	GO:0044092	258	0.049

Six2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.092
	musculoskeletal system disease	DOID:17	0	0.092

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