Mus musculus

11 known processes

Apex1

apurinic/apyrimidinic endonuclease 1

(Aliases: Apex,Ref-1,HAP1,APE)

Apex1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
organic cyclic compound catabolic processGO:19013612950.313
Human Worm
amine metabolic processGO:0009308450.178
negative regulation of cell proliferationGO:00082852960.139
chromatin organizationGO:00063252060.138
nucleoside phosphate metabolic processGO:00067533380.136
nucleoside triphosphate metabolic processGO:00091412300.133
cellular macromolecule catabolic processGO:00442652060.130
Human Worm
epithelial cell proliferationGO:00506731740.127
regulation of cellular amino acid metabolic processGO:000652150.126
dna metabolic processGO:00062593030.125
Human Worm
rna processingGO:00063961050.117
mrna metabolic processGO:0016071840.115
organophosphate biosynthetic processGO:00904071220.109
gland developmentGO:00487323300.086
regulation of cellular amine metabolic processGO:0033238200.083
regulation of cellular ketone metabolic processGO:0010565660.077
cytoplasmic transportGO:00164822340.076
nucleoside metabolic processGO:00091162460.075
nucleotide metabolic processGO:00091173320.074
cellular amino acid metabolic processGO:00065201030.069
posttranscriptional regulation of gene expressionGO:00106081550.067
Human
regulation of epithelial cell proliferationGO:00506781410.067
ribose phosphate metabolic processGO:00196932910.066
cellular response to dna damage stimulusGO:00069742070.062
Human Worm
cellular ketone metabolic processGO:0042180840.062
cellular amine metabolic processGO:0044106440.062
embryonic organ morphogenesisGO:00485622760.060
Zebrafish
atp metabolic processGO:0046034750.059
cellular nitrogen compound catabolic processGO:00442702800.059
Human Worm
camera type eye developmentGO:00430102660.059
purine containing compound metabolic processGO:00725213110.059
macromolecule catabolic processGO:00090572810.055
Human Worm
purine nucleotide metabolic processGO:00061633020.055
peptidyl amino acid modificationGO:00181933360.054
t cell activationGO:00421102890.054
positive regulation of cellular amino acid metabolic processGO:004576430.054
positive regulation of protein modification processGO:00314012990.054
rhythmic processGO:00485111740.053
development of primary sexual characteristicsGO:00451371430.053
rna splicingGO:0008380540.051
regulation of organelle organizationGO:00330432890.051
leukocyte proliferationGO:00706611720.049
chromatin modificationGO:00165681870.049
chemotaxisGO:00069352470.048
regulation of organ morphogenesisGO:20000271440.048
purine ribonucleoside triphosphate metabolic processGO:00092052200.047
hematopoietic progenitor cell differentiationGO:00022441430.046
cytokine productionGO:00018163190.046
lymphocyte proliferationGO:00466511640.045
transmembrane transportGO:00550854120.045
organonitrogen compound biosynthetic processGO:19015661920.045
myeloid cell differentiationGO:00300992330.043
nucleobase containing small molecule metabolic processGO:00550863520.043
regulation of ion transportGO:00432692150.043
gonad developmentGO:00084061410.043
female gamete generationGO:0007292740.043
intrinsic apoptotic signaling pathwayGO:00971931320.043
positive regulation of cellular amine metabolic processGO:003324050.043
apoptotic signaling pathwayGO:00971903060.041
regulation of cell migrationGO:00303342190.041
covalent chromatin modificationGO:00165691630.040
actin cytoskeleton organizationGO:00300362200.040
regulation of protein localizationGO:00328802310.040
nucleoside phosphate biosynthetic processGO:1901293790.040
cellular response to organonitrogen compoundGO:00714171450.039
small gtpase mediated signal transductionGO:0007264970.039
sensory organ morphogenesisGO:00905962420.039
negative regulation of epithelial cell proliferationGO:0050680640.039
negative regulation of phosphate metabolic processGO:00459361840.039
glycosyl compound metabolic processGO:19016572460.039
generation of precursor metabolites and energyGO:00060911030.038
mapk cascadeGO:00001652810.037
organelle fissionGO:00482851700.037
rna splicing via transesterification reactionsGO:0000375430.036
nucleotide biosynthetic processGO:0009165780.036
ras protein signal transductionGO:0007265770.036
macromolecule methylationGO:00434141200.036
ion transmembrane transportGO:00342203610.035
glial cell differentiationGO:00100011310.035
cell divisionGO:00513011200.035
nucleoside phosphate catabolic processGO:19012922220.035
cellular response to cytokine stimulusGO:00713451890.035
negative regulation of molecular functionGO:00440922580.035
positive regulation of apoptotic processGO:00430652170.035
maturation of ssu rrnaGO:003049010.034
purine ribonucleoside triphosphate catabolic processGO:00092071990.034
purine nucleoside metabolic processGO:00422782410.034
purine nucleotide biosynthetic processGO:0006164650.032
regulation of inflammatory responseGO:00507271470.032
histone modificationGO:00165701590.032
regulation of cell cycleGO:00517262810.032
negative regulation of protein metabolic processGO:00512482820.032
regionalizationGO:00030023370.032
transcription coupled nucleotide excision repairGO:000628320.031
dna repairGO:00062811070.031
Human Worm
positive regulation of cell developmentGO:00107202370.031
proteolysis involved in cellular protein catabolic processGO:00516031470.031
regulation of sequence specific dna binding transcription factor activityGO:00510901060.030
mitochondrion organizationGO:00070051340.030
neuron projection guidanceGO:00974851410.030
regulation of proteolysisGO:00301621640.030
cation transportGO:00068123990.030
positive regulation of protein phosphorylationGO:00019342420.029
stem cell differentiationGO:00488632680.029
regulation of transmembrane transportGO:00347621280.029
regulation of hydrolase activityGO:00513362460.029
ribonucleotide metabolic processGO:00092592910.028
respiratory system developmentGO:00605411900.028
ribonucleoside triphosphate metabolic processGO:00091992200.028
mitotic cell cycleGO:00002781950.028
regulation of membrane potentialGO:00423911920.028
protein modification by small protein conjugation or removalGO:00706472070.028
nuclear divisionGO:00002801580.027
cellular homeostasisGO:00197252400.027
negative regulation of cellular amino acid metabolic processGO:004576300.027
regulation of hormone levelsGO:00108172110.027
ribonucleoside metabolic processGO:00091192450.026
regulation of feeding behaviorGO:006025930.026
positive regulation of programmed cell deathGO:00430682180.026
purine containing compound biosynthetic processGO:0072522700.026
dna dealkylationGO:0035510110.026
Human
nitrogen compound transportGO:00717052710.026
branching morphogenesis of an epithelial tubeGO:00487541590.026
methylationGO:00322591340.026
trna wobble uridine modificationGO:000209820.025
protein processingGO:00164851630.025
histone methylationGO:0016571710.025
leukocyte migrationGO:00509001240.025
symbiosis encompassing mutualism through parasitismGO:0044403830.025
ossificationGO:00015032160.025
positive regulation of cell deathGO:00109422240.025
regulation of defense responseGO:00313472330.024
negative regulation of protein phosphorylationGO:00019331260.024
modification dependent macromolecule catabolic processGO:00436321330.024
response to acid chemicalGO:00011011110.024
purine ribonucleotide metabolic processGO:00091502900.024
purine containing compound catabolic processGO:00725232130.024
male gamete generationGO:00482322850.024
regulation of mapk cascadeGO:00434082480.024
negative regulation of apoptotic signaling pathwayGO:20012341040.024
trna wobble base modificationGO:000209720.024
cation homeostasisGO:00550802120.024
negative regulation of intracellular signal transductionGO:19025321670.023
ribonucleoside monophosphate metabolic processGO:0009161800.023
leukocyte differentiationGO:00025213420.023
protein maturationGO:00516041760.023
sensory perceptionGO:00076002450.023
regulation of neuron differentiationGO:00456642810.023
mrna processingGO:0006397630.023
carbohydrate derivative biosynthetic processGO:19011371830.022
segmentationGO:0035282930.022
wound healingGO:00420601570.022
developmental growth involved in morphogenesisGO:00605601380.022
regulation of leukocyte differentiationGO:19021051590.022
molting cycleGO:0042303900.022
regulation of cell growthGO:0001558910.022
axonogenesisGO:00074092740.021
regulation of ion transmembrane transportGO:00347651190.021
regulation of cell morphogenesis involved in differentiationGO:00107691510.021
multicellular organismal homeostasisGO:00488711640.021
carboxylic acid biosynthetic processGO:0046394860.020
negative regulation of phosphorylationGO:00423261660.020
cellular lipid metabolic processGO:00442553230.020
cellular response to acid chemicalGO:0071229680.020
inorganic cation transmembrane transportGO:00986622070.020
nuclear transportGO:00511691390.020
dna templated transcriptional preinitiation complex assemblyGO:007089740.020
regulation of cell motilityGO:20001452360.019
cellular protein catabolic processGO:00442571550.019
response to organonitrogen compoundGO:00102432460.019
nucleoside triphosphate catabolic processGO:00091432050.019
activation of immune responseGO:00022531380.019
regulation of purine nucleotide metabolic processGO:19005421690.019
negative regulation of cellular protein metabolic processGO:00322692470.019
innate immune responseGO:00450871570.019
gliogenesisGO:00420631410.019
regulation of cytokine productionGO:00018172660.019
anion transportGO:00068201770.019
purine nucleotide catabolic processGO:00061952110.018
negative regulation of cell developmentGO:00107211690.018
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.018
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.018
anatomical structure homeostasisGO:00602491450.018
double strand break repair via nonhomologous end joiningGO:0006303100.018
striated muscle tissue developmentGO:00147062930.018
purine nucleoside monophosphate metabolic processGO:0009126810.017
cell adhesionGO:00071553290.017
morphogenesis of a branching epitheliumGO:00611381930.017
negative regulation of multi organism processGO:0043901680.017
protein ubiquitinationGO:00165671710.017
protein acylationGO:0043543640.017
divalent inorganic cation homeostasisGO:00725071380.017
alpha amino acid metabolic processGO:1901605590.017
engulfment of apoptotic cellGO:004365230.017
response to organic cyclic compoundGO:00140701980.017
regulation of nucleoside metabolic processGO:00091181300.017
metal ion homeostasisGO:00550651890.017
forebrain developmentGO:00309003020.017
t cell differentiationGO:00302171740.017
carbohydrate derivative catabolic processGO:19011362310.016
inflammatory responseGO:00069542440.016
locomotory behaviorGO:00076261950.016
negative regulation of cell cycleGO:00457861230.016
intracellular receptor signaling pathwayGO:0030522740.016
mrna 3 end processingGO:0031124160.016
negative regulation of protein modification processGO:00314001630.016
ribose phosphate biosynthetic processGO:0046390590.016
germ cell developmentGO:00072811850.016
retina development in camera type eyeGO:00600411190.016
purine ribonucleoside metabolic processGO:00461282410.016
regulation of apoptotic signaling pathwayGO:20012331970.016
cell growthGO:00160491300.016
oxidation reduction processGO:00551143420.016
Human
spermatogenesisGO:00072832840.015
ncrna processingGO:0034470260.015
mesenchymal cell differentiationGO:00487621070.015
signal transduction by p53 class mediatorGO:0072331510.015
sodium ion transportGO:0006814730.015
cellular response to hormone stimulusGO:00328701500.015
negative regulation of cellular amine metabolic processGO:003323910.015
cellular response to oxidative stressGO:0034599760.015
regulation of sarcomere organizationGO:006029740.015
cellular chemical homeostasisGO:00550822150.015
canonical wnt signaling pathwayGO:00600701300.015
epidermis developmentGO:00085441870.015
reactive oxygen species metabolic processGO:0072593840.015
negative regulation of phosphorus metabolic processGO:00105631840.015
regulation of jak stat cascadeGO:0046425340.015
regulation of protein kinase activityGO:00458592320.015
calcium ion transportGO:00068161590.015
regulation of establishment of protein localizationGO:00702011810.015
positive regulation of cellular respirationGO:190185730.015
regulation of endopeptidase activityGO:0052548890.014
positive regulation of peptidase activityGO:0010952490.014
hematopoietic stem cell differentiationGO:006021880.014
cellular response to external stimulusGO:0071496880.014
mrna splicing via spliceosomeGO:0000398430.014
oocyte anterior posterior axis specificationGO:000731420.014
negative regulation of mammary gland epithelial cell proliferationGO:003360030.014
cell type specific apoptotic processGO:00972852680.014
cation transmembrane transportGO:00986552660.014
negative regulation of immune system processGO:00026832090.014
regulation of peptidyl tyrosine phosphorylationGO:0050730930.014
purine nucleoside triphosphate catabolic processGO:00091462030.014
regulation of kinase activityGO:00435492490.013
protein modification by small protein conjugationGO:00324461870.013
purine nucleoside catabolic processGO:00061522050.013
wnt signaling pathwayGO:00160551880.013
notch signaling pathwayGO:0007219710.013
regulation of ras protein signal transductionGO:00465781140.013
purine nucleoside triphosphate metabolic processGO:00091442260.013
positive regulation of mapk cascadeGO:00434101700.013
blastocyst developmentGO:0001824800.013
inorganic ion transmembrane transportGO:00986602340.013
regulation of secretion by cellGO:19035302490.013
oogenesisGO:0048477560.013
myeloid leukocyte differentiationGO:00025731190.013
nucleotide catabolic processGO:00091662170.013
nucleocytoplasmic transportGO:00069131390.013
pharynx developmentGO:006046510.013
regulation of mitotic cell cycle phase transitionGO:1901990730.013
response to drugGO:0042493750.013
aromatic compound catabolic processGO:00194392860.013
Human Worm
regulation of cellular response to stressGO:00801351590.013
Human
muscle tissue developmentGO:00605373080.013
regulation of transporter activityGO:0032409570.012
morphogenesis of a branching structureGO:00017632030.012
response to oxidative stressGO:00069791230.012
multicellular organismal signalingGO:0035637910.012
mesenchyme developmentGO:00604851520.012
cellular metal ion homeostasisGO:00068751510.012
peptidyl lysine modificationGO:0018205770.012
purine ribonucleoside catabolic processGO:00461302050.012
urogenital system developmentGO:00016552610.012
maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:000046310.012
cellular response to lipidGO:00713961450.012
peptidyl lysine acetylationGO:0018394450.012
endocytosisGO:00068971680.012
small molecule biosynthetic processGO:00442831320.012
synaptic transmissionGO:00072683290.012
response to extracellular stimulusGO:00099911270.012
dna dependent dna replicationGO:0006261240.012
axon guidanceGO:00074111410.012
nucleoside monophosphate metabolic processGO:0009123850.012
response to inorganic substanceGO:0010035960.012
multicellular organism growthGO:00352641610.012
purine ribonucleoside monophosphate metabolic processGO:0009167800.012
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281620.012
response to peptideGO:19016521360.012
amide transportGO:00428861380.011
divalent metal ion transportGO:00708381720.011
organophosphate catabolic processGO:00464342320.011
regulation of glial cell differentiationGO:0045685410.011
regulation of intracellular protein transportGO:0033157820.011
protein localization to organelleGO:00333651850.011
negative regulation of hydrolase activityGO:0051346710.011
cellular protein complex assemblyGO:00436231160.011
mitotic cell cycle processGO:19030471590.011
peptide secretionGO:00027901140.011
positive regulation of hydrolase activityGO:00513451480.011
polyamine biosynthetic processGO:000659620.011
blood circulationGO:00080151950.011
Zebrafish
interspecies interaction between organismsGO:0044419830.011
regulation of reactive oxygen species metabolic processGO:2000377400.011
organic acid biosynthetic processGO:0016053860.011
g protein coupled receptor signaling pathwayGO:00071862430.011
placenta developmentGO:00018901400.011
regulation of neuron projection developmentGO:00109751690.011
body morphogenesisGO:0010171450.011
regulation of protein catabolic processGO:00421761080.011
circulatory system processGO:00030131970.011
Zebrafish
nuclear exportGO:0051168340.011
skin developmentGO:00435882200.011
positive regulation of cytokine productionGO:00018191740.011
peptide transportGO:00158331330.011
mesenchymal cell developmentGO:0014031930.011
regulation of rna splicingGO:0043484370.011
skeletal system morphogenesisGO:00487052030.011
columnar cuboidal epithelial cell differentiationGO:0002065820.011
negative regulation of growthGO:0045926990.011
developmental programmed cell deathGO:0010623410.010
regulation of myeloid cell differentiationGO:0045637960.010
cellular response to peptideGO:1901653920.010
organelle localizationGO:00516401790.010
protein oligomerizationGO:0051259670.010
protein kinase b signalingGO:0043491740.010
oocyte constructionGO:000730820.010
dna demethylationGO:0080111100.010
Human
divalent inorganic cation transportGO:00725111780.010
cellularizationGO:000734910.010
positive regulation of proteolysisGO:0045862850.010
positive regulation of sequence specific dna binding transcription factor activityGO:0051091680.010
regulation of protein processingGO:0070613960.010
peptidyl tyrosine modificationGO:00182121450.010
ribonucleotide biosynthetic processGO:0009260590.010
digestive system developmentGO:00551232000.010
protein catabolic processGO:00301632210.010
regulation of protein kinase b signalingGO:0051896560.010

Apex1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.028
nervous system diseaseDOID:86300.028
central nervous system diseaseDOID:33100.022
neurodegenerative diseaseDOID:128900.022
disease of cellular proliferationDOID:1456600.012