Mus musculus

35 known processes

Optn

optineurin

(Aliases: HYPL,4930441O07Rik,NRP,FIP2)

Optn biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
macromolecule catabolic processGO:00090572810.126
protein modification by small protein conjugationGO:00324461870.108
cellular ketone metabolic processGO:0042180840.106
protein modification by small protein conjugation or removalGO:00706472070.106
membrane organizationGO:00610242450.102
cellular lipid metabolic processGO:00442553230.098
regulation of cellular amino acid metabolic processGO:000652150.095
endomembrane system organizationGO:00102561470.082
cellular amine metabolic processGO:0044106440.080
protein ubiquitinationGO:00165671710.075
cellular amino acid metabolic processGO:00065201030.065
positive regulation of macroautophagyGO:001623930.065
regulation of cellular amine metabolic processGO:0033238200.063
amine metabolic processGO:0009308450.062
proteolysis involved in cellular protein catabolic processGO:00516031470.062
modification dependent protein catabolic processGO:00199411330.052
oxidation reduction processGO:00551143420.052
positive regulation of cellular amine metabolic processGO:003324050.050
fatty acid metabolic processGO:00066311210.048
apoptotic signaling pathwayGO:00971903060.047
cellular macromolecule catabolic processGO:00442652060.045
regulation of cellular catabolic processGO:00313292420.043
transmembrane transportGO:00550854120.043
cation transportGO:00068123990.043
cellular homeostasisGO:00197252400.043
membrane fusionGO:0061025380.042
positive regulation of protein phosphorylationGO:00019342420.042
modification dependent macromolecule catabolic processGO:00436321330.041
spermatogenesisGO:00072832840.041
positive regulation of protein modification processGO:00314012990.041
mapk cascadeGO:00001652810.040
homeostasis of number of cellsGO:00488722100.038
peptidyl amino acid modificationGO:00181933360.037
organic hydroxy compound metabolic processGO:19016152030.037
nucleotide metabolic processGO:00091173320.036
nucleobase containing small molecule metabolic processGO:00550863520.036
regulation of cellular ketone metabolic processGO:0010565660.036
organic cyclic compound catabolic processGO:19013612950.035
i kappab kinase nf kappab signalingGO:0007249850.035
male gamete generationGO:00482322850.034
negative regulation of cellular component organizationGO:00511291940.034
response to organic cyclic compoundGO:00140701980.034
lipid modificationGO:0030258650.033
positive regulation of cellular catabolic processGO:00313311480.033
protein oligomerizationGO:0051259670.033
aromatic compound catabolic processGO:00194392860.033
response to extracellular stimulusGO:00099911270.032
cellular response to cytokine stimulusGO:00713451890.032
macroautophagyGO:0016236210.032
cytokine productionGO:00018163190.032
regulation of cell migrationGO:00303342190.032
monocarboxylic acid metabolic processGO:00327871910.031
small gtpase mediated signal transductionGO:0007264970.031
carbohydrate metabolic processGO:00059752300.031
nucleoside phosphate metabolic processGO:00067533380.031
positive regulation of cellular amino acid metabolic processGO:004576430.031
cellular response to arsenic containing substanceGO:007124340.030
protein polyubiquitinationGO:0000209330.030
purine nucleoside metabolic processGO:00422782410.030
carbohydrate derivative catabolic processGO:19011362310.030
cellular response to extracellular stimulusGO:0031668810.030
regulation of protein serine threonine kinase activityGO:00719001570.030
innate immune responseGO:00450871570.030
regulation of organelle organizationGO:00330432890.029
negative regulation of intracellular signal transductionGO:19025321670.029
negative regulation of molecular functionGO:00440922580.029
lipid biosynthetic processGO:00086101790.029
response to nutrient levelsGO:00316671090.029
regulation of cellular response to stressGO:00801351590.029
cellular response to external stimulusGO:0071496880.029
alcohol metabolic processGO:00060661160.029
regulation of kinase activityGO:00435492490.028
protein catabolic processGO:00301632210.028
leukocyte differentiationGO:00025213420.028
ribose phosphate metabolic processGO:00196932910.027
intracellular protein transportGO:00068862040.027
purine ribonucleotide metabolic processGO:00091502900.027
purine containing compound metabolic processGO:00725213110.027
ion transmembrane transportGO:00342203610.027
lipid catabolic processGO:0016042690.027
regulation of cytokine productionGO:00018172660.027
regulation of membrane potentialGO:00423911920.027
cellular response to nutrient levelsGO:0031669640.027
organonitrogen compound biosynthetic processGO:19015661920.026
ribonucleotide catabolic processGO:00092612080.026
autophagyGO:0006914450.026
skeletal system developmentGO:00015013560.026
negative regulation of cellular protein metabolic processGO:00322692470.026
posttranscriptional regulation of gene expressionGO:00106081550.026
myeloid cell differentiationGO:00300992330.025
organophosphate catabolic processGO:00464342320.025
negative regulation of cellular amino acid metabolic processGO:004576300.025
regulation of transferase activityGO:00513382630.025
nucleoside phosphate catabolic processGO:19012922220.025
locomotory behaviorGO:00076261950.025
ubiquitin dependent protein catabolic processGO:00065111290.025
cellular response to starvationGO:0009267570.025
ribonucleotide metabolic processGO:00092592910.025
immune effector processGO:00022523210.024
cellular protein catabolic processGO:00442571550.024
metal ion homeostasisGO:00550651890.024
purine containing compound catabolic processGO:00725232130.024
regulation of mapk cascadeGO:00434082480.024
cellular response to organonitrogen compoundGO:00714171450.024
mitochondrion degradationGO:000042230.024
glycosyl compound metabolic processGO:19016572460.023
purine nucleotide metabolic processGO:00061633020.023
positive regulation of cell developmentGO:00107202370.023
cellular chemical homeostasisGO:00550822150.023
regulation of defense responseGO:00313472330.023
negative regulation of phosphorus metabolic processGO:00105631840.023
purine ribonucleotide catabolic processGO:00091542080.023
multicellular organismal signalingGO:0035637910.023
camera type eye developmentGO:00430102660.022
male anatomical structure morphogenesisGO:009059840.022
ras protein signal transductionGO:0007265770.022
cation transmembrane transportGO:00986552660.022
cellular nitrogen compound catabolic processGO:00442702800.022
heterocycle catabolic processGO:00467002800.022
sensory perceptionGO:00076002450.022
nitrogen compound transportGO:00717052710.022
small molecule biosynthetic processGO:00442831320.022
glycerolipid metabolic processGO:00464861220.022
negative regulation of cellular amine metabolic processGO:003323910.022
male genitalia morphogenesisGO:004880840.022
cellular lipid catabolic processGO:0044242520.022
purine ribonucleoside metabolic processGO:00461282410.021
cellular response to lipidGO:00713961450.021
organonitrogen compound catabolic processGO:19015652640.021
nucleoside catabolic processGO:00091642060.021
regulation of apoptotic signaling pathwayGO:20012331970.021
response to peptideGO:19016521360.021
negative regulation of protein metabolic processGO:00512482820.020
nucleoside metabolic processGO:00091162460.020
regulation of hormone levelsGO:00108172110.020
development of primary sexual characteristicsGO:00451371430.020
divalent metal ion transportGO:00708381720.020
cellular ion homeostasisGO:00068731650.020
cell adhesionGO:00071553290.020
response to inorganic substanceGO:0010035960.020
regulation of body fluid levelsGO:00508781620.020
maintenance of locationGO:0051235890.020
microtubule based processGO:00070172360.020
gland developmentGO:00487323300.020
small molecule catabolic processGO:0044282710.020
actin cytoskeleton organizationGO:00300362200.020
action potentialGO:0001508780.020
adult behaviorGO:00305341350.020
ossificationGO:00015032160.020
negative regulation of phosphate metabolic processGO:00459361840.020
protein maturationGO:00516041760.020
neuronal action potentialGO:0019228540.019
skin developmentGO:00435882200.019
ribonucleoside metabolic processGO:00091192450.019
transmission of nerve impulseGO:0019226760.019
monocarboxylic acid catabolic processGO:0072329270.019
organic anion transportGO:00157111370.019
reactive nitrogen species metabolic processGO:200105700.019
regulation of anatomical structure sizeGO:00900661780.019
cell maturationGO:00484691270.019
cell type specific apoptotic processGO:00972852680.019
positive regulation of organelle organizationGO:00106381280.019
microtubule cytoskeleton organizationGO:00002261570.019
negative regulation of protein modification processGO:00314001630.019
cytoplasmic transportGO:00164822340.019
anion transportGO:00068201770.019
carboxylic acid transportGO:00469421000.019
epithelial cell proliferationGO:00506731740.018
cofactor metabolic processGO:0051186800.018
cellular response to oxidative stressGO:0034599760.018
muscle tissue developmentGO:00605373080.018
chromatin organizationGO:00063252060.018
divalent inorganic cation transportGO:00725111780.018
response to starvationGO:0042594650.018
regulation of intrinsic apoptotic signaling pathwayGO:2001242610.018
intrinsic apoptotic signaling pathwayGO:00971931320.018
fat cell differentiationGO:00454441600.018
placenta developmentGO:00018901400.018
multicellular organismal homeostasisGO:00488711640.018
t cell activationGO:00421102890.018
protein importGO:00170381010.017
spermatid developmentGO:00072861080.017
myeloid leukocyte differentiationGO:00025731190.017
glycosyl compound catabolic processGO:19016582060.017
regulation of cellular component biogenesisGO:00440871810.017
purine ribonucleoside catabolic processGO:00461302050.017
regulation of lymphocyte activationGO:00512492400.017
synaptic transmissionGO:00072683290.017
cellular metal ion homeostasisGO:00068751510.017
response to acid chemicalGO:00011011110.017
inorganic cation transmembrane transportGO:00986622070.017
protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:0042787250.017
immune response activating signal transductionGO:00027571160.017
carboxylic acid biosynthetic processGO:0046394860.017
organophosphate biosynthetic processGO:00904071220.017
reactive oxygen species metabolic processGO:0072593840.016
cellular response to molecule of bacterial originGO:0071219830.016
chromatin modificationGO:00165681870.016
regulation of protein kinase activityGO:00458592320.016
defense response to other organismGO:00985421970.016
lateral inhibitionGO:004633110.016
regulation of proteolysisGO:00301621640.016
central nervous system neuron differentiationGO:00219531620.016
nucleoside triphosphate catabolic processGO:00091432050.016
calcium ion transportGO:00068161590.016
regulation of reactive oxygen species metabolic processGO:2000377400.016
lipid oxidationGO:0034440290.016
response to lipopolysaccharideGO:00324961280.016
establishment of protein localization to organelleGO:00725941180.016
positive regulation of mapk cascadeGO:00434101700.016
organic acid biosynthetic processGO:0016053860.016
activation of immune responseGO:00022531380.016
negative regulation of phosphorylationGO:00423261660.016
cellular carbohydrate metabolic processGO:00442621190.016
positive regulation of nervous system developmentGO:00519622210.015
organic acid transportGO:00158491010.015
sulfur compound metabolic processGO:00067901000.015
purine nucleoside triphosphate metabolic processGO:00091442260.015
circulatory system processGO:00030131970.015
nucleotide catabolic processGO:00091662170.015
g protein coupled receptor signaling pathwayGO:00071862430.015
negative regulation of intrinsic apoptotic signaling pathwayGO:2001243340.015
regulation of endopeptidase activityGO:0052548890.015
purine nucleoside catabolic processGO:00061522050.015
regulation of hydrolase activityGO:00513362460.015
negative regulation of protein phosphorylationGO:00019331260.015
regulation of metal ion transportGO:00109591060.015
regulation of secretionGO:00510462740.015
compound eye developmentGO:004874910.015
cation homeostasisGO:00550802120.015
regulation of ion transmembrane transportGO:00347651190.015
positive regulation of programmed cell deathGO:00430682180.015
regulation of cell activationGO:00508652890.015
leukocyte proliferationGO:00706611720.015
positive regulation of cell deathGO:00109422240.015
protein processingGO:00164851630.015
gonad developmentGO:00084061410.015
organelle fissionGO:00482851700.015
male sex differentiationGO:00466611090.015
lymphocyte differentiationGO:00300982420.015
epithelial tube morphogenesisGO:00605623030.015
muscle cell differentiationGO:00426922610.015
regulation of ion transportGO:00432692150.015
forebrain developmentGO:00309003020.015
cellular response to inorganic substanceGO:0071241370.014
plasma membrane organizationGO:0007009900.014
protein targetingGO:00066051430.014
inorganic ion transmembrane transportGO:00986602340.014
regulation of protein localizationGO:00328802310.014
nucleocytoplasmic transportGO:00069131390.014
regulation of cell cycleGO:00517262810.014
cytokine mediated signaling pathwayGO:00192211150.014
positive regulation of hydrolase activityGO:00513451480.014
fatty acid beta oxidationGO:0006635160.014
regulation of secretion by cellGO:19035302490.014
carbohydrate derivative biosynthetic processGO:19011371830.014
regulation of cell motilityGO:20001452360.014
response to peptide hormoneGO:00434341270.014
endocytosisGO:00068971680.014
male gonad developmentGO:0008584880.014
protein localization to nucleusGO:00345041210.014
positive regulation of kinase activityGO:00336741550.014
regulation of bindingGO:00510981110.014
response to epidermal growth factorGO:007084940.014
organelle localizationGO:00516401790.014
developmental maturationGO:00217001930.014
anatomical structure homeostasisGO:00602491450.014
regulation of autophagyGO:0010506300.014
regulation of protein transportGO:00512231630.014
lymphocyte proliferationGO:00466511640.014
regulation of nucleoside metabolic processGO:00091181300.014
rho protein signal transductionGO:0007266320.014
purine nucleoside triphosphate catabolic processGO:00091462030.013
divalent inorganic cation homeostasisGO:00725071380.013
regulation of cytoskeleton organizationGO:00514931220.013
germ cell developmentGO:00072811850.013
stress activated mapk cascadeGO:0051403800.013
muscle system processGO:00030121410.013
response to organonitrogen compoundGO:00102432460.013
positive regulation of protein kinase activityGO:00458601440.013
axonogenesisGO:00074092740.013
lipid localizationGO:00108761260.013
regulation of neuron differentiationGO:00456642810.013
regulation of system processGO:00440572000.013
cell growthGO:00160491300.013
dephosphorylationGO:00163111290.013
regulation of vesicle mediated transportGO:00606271390.013
negative regulation of apoptotic signaling pathwayGO:20012341040.013
cellular protein complex assemblyGO:00436231160.013
hematopoietic progenitor cell differentiationGO:00022441430.013
cytokine biosynthetic processGO:0042089680.013
purine ribonucleoside triphosphate metabolic processGO:00092052200.013
single organism nuclear importGO:1902593950.013
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.013
cellular response to cadmium ionGO:007127630.013
blood circulationGO:00080151950.013
actin filament organizationGO:00070151130.013
cellular response to acid chemicalGO:0071229680.013
regulation of purine nucleotide metabolic processGO:19005421690.013
monosaccharide metabolic processGO:00059961060.013
regulation of response to woundingGO:19030341890.013
striated muscle tissue developmentGO:00147062930.013
nuclear divisionGO:00002801580.013
purine nucleotide catabolic processGO:00061952110.013
response to insulinGO:00328681000.013
metencephalon developmentGO:0022037890.013
sequestering of metal ionGO:0051238190.013
blood vessel morphogenesisGO:00485142850.013
reactive oxygen species biosynthetic processGO:190340980.013
cellular response to organic cyclic compoundGO:0071407870.013
regulation of homeostatic processGO:00328441820.013
regulation of purine nucleotide catabolic processGO:00331211220.013
positive regulation of monocyte chemotaxisGO:009002620.013
regulation of sequence specific dna binding transcription factor activityGO:00510901060.013
negative regulation of organelle organizationGO:0010639900.012
negative regulation of cell developmentGO:00107211690.012
fertilizationGO:00095661270.012
histone modificationGO:00165701590.012
cell junction maintenanceGO:003433140.012
positive regulation of cytokine productionGO:00018191740.012
positive regulation of lymphocyte activationGO:00512511400.012
embryonic organ morphogenesisGO:00485622760.012
nuclear transportGO:00511691390.012
wound healingGO:00420601570.012
regulation of transmembrane transportGO:00347621280.012
protein localization to organelleGO:00333651850.012
translationGO:0006412930.012
sensory organ morphogenesisGO:00905962420.012
meiosis iGO:0007127600.012
response to molecule of bacterial originGO:00022371430.012
interleukin 8 productionGO:003263740.012
inflammatory responseGO:00069542440.012
positive regulation of apoptotic processGO:00430652170.012
acetate metabolic processGO:000608310.012
glycerolipid biosynthetic processGO:0045017500.012
ribonucleoside triphosphate metabolic processGO:00091992200.012
regulation of t cell activationGO:00508631700.012
myeloid cell homeostasisGO:00022621140.012
muscle contractionGO:00069361010.012
regulation of cellular component sizeGO:00325351210.012
cellularizationGO:000734910.012
neuron deathGO:00709971540.012
positive regulation of transferase activityGO:00513471670.012
rna interferenceGO:001624620.012
response to endoplasmic reticulum stressGO:0034976530.012
positive regulation of defense responseGO:00313491240.012
regulation of establishment of protein localizationGO:00702011810.012
epithelial cell developmentGO:00020641590.012
peptidyl serine modificationGO:0018209830.012
nucleoside triphosphate metabolic processGO:00091412300.012
phospholipid metabolic processGO:0006644870.012
interspecies interaction between organismsGO:0044419830.012
fatty acid catabolic processGO:0009062250.012
regulation of innate immune responseGO:0045088910.011
response to oxygen levelsGO:0070482620.011
regulation of reactive oxygen species biosynthetic processGO:190342620.011
monocarboxylic acid biosynthetic processGO:0072330610.011
calcium ion homeostasisGO:00550741270.011
regulation of multi organism processGO:00439001110.011
positive regulation of protein serine threonine kinase activityGO:00719021060.011
single organism cell adhesionGO:00986021560.011
guanosine containing compound catabolic processGO:19010691440.011
lipid transportGO:0006869980.011
ribonucleoside catabolic processGO:00424542060.011
glucose metabolic processGO:0006006920.011
developmental growth involved in morphogenesisGO:00605601380.011
coenzyme metabolic processGO:0006732520.011
regulation of fat cell differentiationGO:0045598810.011
carboxylic acid catabolic processGO:0046395510.011
sequestering of calcium ionGO:0051208180.011
meiotic cell cycleGO:00513211220.011
negative regulation of immune system processGO:00026832090.011
purine ribonucleoside triphosphate catabolic processGO:00092071990.011
amide transportGO:00428861380.011
ribonucleoside triphosphate catabolic processGO:00092031990.011
positive regulation of fatty acid oxidationGO:004632140.011
cellular divalent inorganic cation homeostasisGO:00725031270.011
regulation of protein catabolic processGO:00421761080.011
cerebellar cortex developmentGO:0021695480.011
negative regulation of cell activationGO:00508661110.011
cellular amide metabolic processGO:0043603580.011
nuclear importGO:0051170950.011
protein localization to membraneGO:00726571080.011
peptidyl serine phosphorylationGO:0018105740.011
cytokine metabolic processGO:0042107710.011
regulation of lipid metabolic processGO:00192161180.011
peptide transportGO:00158331330.011
digestive system developmentGO:00551232000.011
regulation of neuron apoptotic processGO:00435231220.011
positive regulation of reactive oxygen species biosynthetic processGO:190342820.011
digestive tract developmentGO:00485651900.011
cell substrate adhesionGO:00315891300.011
response to radiationGO:00093141650.011
cellular response to dna damage stimulusGO:00069742070.011
immune response regulating signaling pathwayGO:00027641250.011
myelinationGO:0042552740.011
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281620.011
mitochondrion organizationGO:00070051340.011
spermatid differentiationGO:00485151150.011
hexose metabolic processGO:0019318980.011
cellular response to biotic stimulusGO:0071216920.011
ensheathment of neuronsGO:0007272760.011
cellular alcohol biosynthetic processGO:004410830.011
neuron apoptotic processGO:00514021420.011
positive regulation of growthGO:00459271040.011
positive regulation of proteolysisGO:0045862850.011
membrane tubulationGO:009732040.011
glial cell differentiationGO:00100011310.010
asymmetric stem cell divisionGO:009872230.010
cellular response to hormone stimulusGO:00328701500.010
regulation of mitochondrial fissionGO:009014030.010
regulation of mitotic cell cycleGO:00073461260.010
dna metabolic processGO:00062593030.010
regulation of nucleotide catabolic processGO:00308111220.010
regulation of interleukin 8 productionGO:003267730.010
fat soluble vitamin biosynthetic processGO:004236240.010
regulation of cell adhesionGO:00301551540.010
regulation of translationGO:0006417710.010
response to amino acidGO:0043200370.010
positive regulation of nucleotide metabolic processGO:00459811140.010
male meiosisGO:0007140370.010
leukocyte migrationGO:00509001240.010
protein import into nucleusGO:0006606950.010
regulation of cell projection organizationGO:00313442060.010
epidermis developmentGO:00085441870.010
neutral lipid metabolic processGO:0006638570.010
oocyte axis specificationGO:000730920.010
regulation of map kinase activityGO:00434051200.010
mitotic cell cycle processGO:19030471590.010
exocytosisGO:00068871210.010

Optn disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
connective tissue diseaseDOID:6500.134
disease of anatomical entityDOID:700.134
musculoskeletal system diseaseDOID:1700.134
bone diseaseDOID:008000100.076
bone remodeling diseaseDOID:008000500.061
disease of metabolismDOID:001466700.030
nervous system diseaseDOID:86300.019
central nervous system diseaseDOID:33100.017
inherited metabolic disorderDOID:65500.016
sensory system diseaseDOID:005015500.014
organ system cancerDOID:005068600.013
disease of cellular proliferationDOID:1456600.013
cancerDOID:16200.013
cardiovascular system diseaseDOID:128700.013
immune system diseaseDOID:291400.012
neuromuscular diseaseDOID:44000.011
neuropathyDOID:87000.011
eye and adnexa diseaseDOID:149200.011
eye diseaseDOID:561400.010