Mus musculus

198 known processes

Mlh1

mutL homolog 1 (E. coli)

(Aliases: AI325952,AI317206,AI561766,1110035C23Rik)

Mlh1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular response to dna damage stimulusGO:00069742070.696
double strand break repairGO:0006302480.693
dna repairGO:00062811070.684
rna 3 end processingGO:0031123200.440
dna replicationGO:0006260520.420
dna metabolic processGO:00062593030.418
cellular hyperosmotic salinity responseGO:007147500.415
double strand break repair via nonhomologous end joiningGO:0006303100.312
intra s dna damage checkpointGO:003157340.268
mrna 3 end processingGO:0031124160.260
non recombinational repairGO:0000726100.212
negative regulation of dna replicationGO:000815640.200
cellular amino acid metabolic processGO:00065201030.170
organelle fissionGO:00482851700.159
regulation of cell cycleGO:00517262810.129
amine metabolic processGO:0009308450.108
apoptotic signaling pathwayGO:00971903060.095
base excision repairGO:000628490.094
dna dependent dna replicationGO:0006261240.094
telomere cappingGO:001623340.089
signal transduction involved in dna damage checkpointGO:007242230.089
response to ionizing radiationGO:0010212420.088
intrinsic apoptotic signaling pathwayGO:00971931320.087
trna wobble base modificationGO:000209720.085
positive regulation of cell deathGO:00109422240.083
macromolecule catabolic processGO:00090572810.082
nuclear divisionGO:00002801580.076
negative regulation of cell cycleGO:00457861230.075
dna integrity checkpointGO:0031570280.073
positive regulation of apoptotic processGO:00430652170.069
cellular response to ionizing radiationGO:0071479110.068
ncrna 3 end processingGO:004362820.066
response to radiationGO:00093141650.066
negative regulation of mitotic cell cycleGO:0045930580.064
regulation of chromosome organizationGO:0033044830.064
regulation of cellular ketone metabolic processGO:0010565660.062
positive regulation of cellular amino acid metabolic processGO:004576430.062
hematopoietic progenitor cell differentiationGO:00022441430.062
nucleic acid phosphodiester bond hydrolysisGO:0090305490.062
cellular ketone metabolic processGO:0042180840.061
cellular nitrogen compound catabolic processGO:00442702800.061
mitotic cell cycleGO:00002781950.057
mitotic cell cycle checkpointGO:0007093310.056
anatomical structure homeostasisGO:00602491450.056
cellular amine metabolic processGO:0044106440.054
positive regulation of cellular amine metabolic processGO:003324050.052
dna damage checkpointGO:0000077260.052
cell cycle checkpointGO:0000075470.051
positive regulation of programmed cell deathGO:00430682180.051
mitotic cell cycle processGO:19030471590.050
regulation of cellular amine metabolic processGO:0033238200.047
response to x rayGO:0010165110.047
regulation of cellular amino acid metabolic processGO:000652150.047
dna catabolic process endonucleolyticGO:0000737150.046
negative regulation of cell cycle processGO:0010948690.046
regulation of mitotic cell cycleGO:00073461260.045
dna recombinationGO:0006310920.044
rna phosphodiester bond hydrolysisGO:0090501190.044
somatic diversification of immune receptorsGO:0002200530.044
production of molecular mediator of immune responseGO:00024401030.043
regulation of cytokine productionGO:00018172660.042
regulation of cell cycle processGO:00105641600.042
organism emergence from protective structureGO:007168440.041
nuclear dna replicationGO:003326030.041
regulation of mitotic cell cycle phase transitionGO:1901990730.039
signal transduction involved in mitotic dna damage checkpointGO:190240230.039
negative regulation of mitotic cell cycle phase transitionGO:1901991450.038
telomere maintenanceGO:0000723190.038
rna processingGO:00063961050.038
dna conformation changeGO:0071103370.037
cytokine productionGO:00018163190.037
chromosome segregationGO:0007059480.037
organonitrogen compound biosynthetic processGO:19015661920.035
regulation of cellular response to stressGO:00801351590.034
response to oxidative stressGO:00069791230.034
cell type specific apoptotic processGO:00972852680.032
lateral inhibitionGO:004633110.032
muscle tissue developmentGO:00605373080.032
dna catabolic processGO:0006308190.032
leukocyte differentiationGO:00025213420.032
posttranscriptional regulation of gene expressionGO:00106081550.031
organic cyclic compound catabolic processGO:19013612950.031
negative regulation of cell cycle phase transitionGO:1901988480.031
microtubule cytoskeleton organizationGO:00002261570.030
regulation of cell cycle phase transitionGO:1901987770.030
heterocycle catabolic processGO:00467002800.030
mrna processingGO:0006397630.029
gland developmentGO:00487323300.029
peptidyl amino acid modificationGO:00181933360.029
somatic cell dna recombinationGO:0016444510.029
meiosis iGO:0007127600.029
protein processingGO:00164851630.029
camera type eye developmentGO:00430102660.029
dna dependent dna replication maintenance of fidelityGO:004500530.029
regulation of defense responseGO:00313472330.028
purine containing compound metabolic processGO:00725213110.028
Yeast
meiotic nuclear divisionGO:00071261150.028
myeloid cell differentiationGO:00300992330.027
multicellular organismal homeostasisGO:00488711640.027
chromatin modificationGO:00165681870.027
regulation of mrna stabilityGO:0043488230.027
negative regulation of cell proliferationGO:00082852960.027
chromatin organizationGO:00063252060.027
protein maturationGO:00516041760.027
positive regulation of cell developmentGO:00107202370.027
t cell differentiation in thymusGO:0033077770.026
regulation of nuclear cell cycle dna replicationGO:003326220.026
homeostasis of number of cellsGO:00488722100.026
signal transduction by p53 class mediatorGO:0072331510.026
purine nucleotide metabolic processGO:00061633020.026
Yeast
cellular response to radiationGO:0071478280.026
stem cell differentiationGO:00488632680.026
nucleobase containing small molecule metabolic processGO:00550863520.025
Yeast
negative regulation of dna dependent dna replicationGO:200010410.025
skin developmentGO:00435882200.025
skeletal muscle organ developmentGO:00605381630.024
signal transduction involved in dna integrity checkpointGO:007240130.024
nucleotide excision repairGO:0006289130.024
neuron deathGO:00709971540.024
gene silencingGO:0016458380.023
meiotic cell cycle processGO:1903046770.023
trna wobble uridine modificationGO:000209820.023
interspecies interaction between organismsGO:0044419830.023
positive regulation of nervous system developmentGO:00519622210.023
positive regulation of protein modification processGO:00314012990.023
blastocyst developmentGO:0001824800.023
rna dependent dna replicationGO:000627830.022
response to organic cyclic compoundGO:00140701980.022
mrna transportGO:0051028130.021
protein acylationGO:0043543640.021
regulation of lymphocyte activationGO:00512492400.021
neuron apoptotic processGO:00514021420.021
cell fate commitmentGO:00451652100.021
reciprocal dna recombinationGO:0035825160.021
regulation of organelle organizationGO:00330432890.021
cellular response to oxidative stressGO:0034599760.021
rna catabolic processGO:0006401290.021
regulation of sequence specific dna binding transcription factor activityGO:00510901060.021
regulation of membrane potentialGO:00423911920.021
positive regulation of cytokine productionGO:00018191740.021
recombinational repairGO:0000725210.021
cellular response to growth factor stimulusGO:00713631970.020
negative regulation of protein metabolic processGO:00512482820.020
cellular response to x rayGO:007148120.020
histone mrna metabolic processGO:000833430.020
intrinsic apoptotic signaling pathway by p53 class mediatorGO:0072332350.019
trna aminoacylation for protein translationGO:000641810.019
extrinsic apoptotic signaling pathwayGO:00971911260.019
negative regulation of cellular protein metabolic processGO:00322692470.019
action potentialGO:0001508780.019
mitotic nuclear divisionGO:0007067480.018
locomotory behaviorGO:00076261950.018
muscle cell differentiationGO:00426922610.018
glial cell differentiationGO:00100011310.018
retina development in camera type eyeGO:00600411190.018
cation transportGO:00068123990.018
digestive system developmentGO:00551232000.018
organonitrogen compound catabolic processGO:19015652640.018
Yeast
response to organonitrogen compoundGO:00102432460.018
positive regulation of protein phosphorylationGO:00019342420.018
mitochondrion organizationGO:00070051340.017
response to gamma radiationGO:0010332220.017
viral processGO:0016032410.017
oxidation reduction processGO:00551143420.017
epithelial tube morphogenesisGO:00605623030.017
glycosyl compound metabolic processGO:19016572460.017
Yeast
carbohydrate derivative biosynthetic processGO:19011371830.017
b cell activationGO:00421131610.017
cell growthGO:00160491300.017
symbiosis encompassing mutualism through parasitismGO:0044403830.017
signal transduction involved in cell cycle checkpointGO:007239530.017
reactive oxygen species metabolic processGO:0072593840.017
rna polyadenylationGO:004363160.017
developmental programmed cell deathGO:0010623410.017
lymphocyte differentiationGO:00300982420.017
sensory organ morphogenesisGO:00905962420.016
purine nucleoside metabolic processGO:00422782410.016
Yeast
regulation of apoptotic signaling pathwayGO:20012331970.016
regulation of neuron deathGO:19012141340.016
regulation of neuron apoptotic processGO:00435231220.016
cellular response to abiotic stimulusGO:0071214560.016
lipoprotein metabolic processGO:0042157430.016
signal transduction involved in mitotic cell cycle checkpointGO:007241330.016
cajal body organizationGO:003057610.016
regulation of dna replicationGO:0006275170.016
mitotic recombinationGO:000631230.016
cell activation involved in immune responseGO:00022631260.016
methylationGO:00322591340.016
nucleoside monophosphate metabolic processGO:0009123850.016
Yeast
regulation of cell activationGO:00508652890.016
chemotaxisGO:00069352470.016
metal ion homeostasisGO:00550651890.016
cellular response to gamma radiationGO:007148040.016
meiotic cell cycleGO:00513211220.016
digestive tract developmentGO:00485651900.015
atp catabolic processGO:0006200550.015
Yeast
calcium ion transportGO:00068161590.015
somatic diversification of immune receptors via germline recombination within a single locusGO:0002562510.015
striated muscle tissue developmentGO:00147062930.015
regulation of histone modificationGO:0031056560.015
wound healingGO:00420601570.015
regulation of chromatin organizationGO:1902275570.015
regulation of reactive oxygen species metabolic processGO:2000377400.015
epidermis developmentGO:00085441870.015
dna endoreduplicationGO:004202340.015
skeletal system developmentGO:00015013560.015
rhythmic processGO:00485111740.015
regulation of hydrolase activityGO:00513362460.015
cellular response to organonitrogen compoundGO:00714171450.015
response to drugGO:0042493750.015
epithelial cell proliferationGO:00506731740.015
divalent inorganic cation transportGO:00725111780.015
t cell activationGO:00421102890.015
mrna metabolic processGO:0016071840.015
regulation of multi organism processGO:00439001110.015
trna metabolic processGO:0006399110.015
histone modificationGO:00165701590.014
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630570.014
response to oxygen levelsGO:0070482620.014
adaptive immune responseGO:00022501550.014
response to lipopolysaccharideGO:00324961280.014
response to uvGO:0009411440.014
lymphocyte mediated immunityGO:00024491390.014
hematopoietic stem cell differentiationGO:006021880.014
protein autophosphorylationGO:0046777610.014
maintenance of locationGO:0051235890.014
nucleoside phosphate catabolic processGO:19012922220.014
Yeast
peptidyl lysine acetylationGO:0018394450.014
nitrogen compound transportGO:00717052710.014
regulation of endopeptidase activityGO:0052548890.014
telomere maintenance via telomeraseGO:000700410.014
immunoglobulin mediated immune responseGO:0016064690.014
regulation of antimicrobial peptide biosynthetic processGO:000280510.014
aromatic compound catabolic processGO:00194392860.014
striated muscle cell developmentGO:00550021250.014
digestive tract morphogenesisGO:00485461470.014
t cell differentiationGO:00302171740.014
organophosphate biosynthetic processGO:00904071220.014
engulfment of apoptotic cellGO:004365230.014
embryonic organ morphogenesisGO:00485622760.014
positive regulation of sequence specific dna binding transcription factor activityGO:0051091680.013
cellular response to peptideGO:1901653920.013
immune effector processGO:00022523210.013
divalent metal ion transportGO:00708381720.013
ribonucleotide catabolic processGO:00092612080.013
Yeast
skeletal muscle cell differentiationGO:0035914660.013
regulation of body fluid levelsGO:00508781620.013
reciprocal meiotic recombinationGO:0007131160.013
germ cell developmentGO:00072811850.013
ribonucleotide metabolic processGO:00092592910.013
Yeast
hyperosmotic salinity responseGO:004253810.013
rna phosphodiester bond hydrolysis exonucleolyticGO:009050340.013
regulation of protein localizationGO:00328802310.013
internal protein amino acid acetylationGO:0006475420.013
positive regulation of protein autophosphorylationGO:003195440.013
regulation of transferase activityGO:00513382630.013
protein palmitoylationGO:0018345140.013
somatic recombination of immunoglobulin gene segmentsGO:0016447420.013
somatic diversification of immune receptors via somatic mutationGO:000256680.013
response to testosteroneGO:003357430.013
regulation of defense response to bacteriumGO:190042430.012
inflammatory responseGO:00069542440.012
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280360.012
tissue homeostasisGO:00018941150.012
cellular lipid metabolic processGO:00442553230.012
regulation of cysteine type endopeptidase activityGO:2000116650.012
pallium developmentGO:00215431200.012
cellular response to acid chemicalGO:0071229680.012
positive regulation of hydrolase activityGO:00513451480.012
ncrna processingGO:0034470260.012
multicellular organismal signalingGO:0035637910.012
gliogenesisGO:00420631410.012
cardiac muscle cell contractionGO:008600370.012
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:190217640.012
regulation of kinase activityGO:00435492490.012
deoxyribose phosphate metabolic processGO:001969290.012
regulation of chromatin modificationGO:1903308570.012
dna templated transcription terminationGO:000635340.012
forebrain developmentGO:00309003020.012
ectopic germ cell programmed cell deathGO:003523490.012
maintenance of protein localization in organelleGO:007259520.012
negative regulation of growthGO:0045926990.012
antimicrobial peptide biosynthetic processGO:000277720.012
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.012
transmembrane transportGO:00550854120.012
cation homeostasisGO:00550802120.011
3 utr mediated mrna stabilizationGO:007093520.011
ribonucleoside catabolic processGO:00424542060.011
Yeast
negative regulation of cellular amino acid metabolic processGO:004576300.011
myeloid leukocyte differentiationGO:00025731190.011
lymphocyte proliferationGO:00466511640.011
positive regulation of endopeptidase activityGO:0010950430.011
pancreas developmentGO:0031016570.011
macromolecule methylationGO:00434141200.011
purine ribonucleoside triphosphate metabolic processGO:00092052200.011
Yeast
regulation of ion transportGO:00432692150.011
regulation of proteolysisGO:00301621640.011
organophosphate catabolic processGO:00464342320.011
Yeast
cellular ion homeostasisGO:00068731650.011
multicellular organism growthGO:00352641610.011
limb developmentGO:00601731660.011
nucleotide metabolic processGO:00091173320.011
Yeast
innate immune responseGO:00450871570.011
negative regulation of immune system processGO:00026832090.011
antibacterial peptide biosynthetic processGO:000278020.011
respiratory system developmentGO:00605411900.011
lipid biosynthetic processGO:00086101790.011
nucleoside metabolic processGO:00091162460.011
Yeast
regulation of cell migrationGO:00303342190.011
stem cell developmentGO:00488642190.011
purine nucleoside monophosphate catabolic processGO:0009128580.011
Yeast
appendage morphogenesisGO:00351071490.011
neuron migrationGO:00017641220.011
regulation of secretion by cellGO:19035302490.010
mitotic g1 dna damage checkpointGO:003157140.010
organelle assemblyGO:00709251770.010
rna interferenceGO:001624620.010
regulation of t cell activationGO:00508631700.010
cellular chemical homeostasisGO:00550822150.010
leukocyte mediated immunityGO:00024431740.010
response to acid chemicalGO:00011011110.010
protein modification by small protein conjugationGO:00324461870.010
leukocyte proliferationGO:00706611720.010
leukocyte activation involved in immune responseGO:00023661260.010
apoptotic dna fragmentationGO:000630970.010
body fluid secretionGO:0007589530.010
regulation of chromatin silencingGO:003193520.010
lymphocyte homeostasisGO:0002260640.010
urogenital system developmentGO:00016552610.010
lymphocyte apoptotic processGO:0070227540.010
positive regulation of apoptotic signaling pathwayGO:2001235950.010
regulation of leukocyte proliferationGO:00706631210.010
hatchingGO:003518840.010
cytoplasmic transportGO:00164822340.010
regulation of symbiosis encompassing mutualism through parasitismGO:0043903520.010
cartilage developmentGO:00512161400.010
carbohydrate derivative catabolic processGO:19011362310.010
Yeast
negative regulation of cellular amine metabolic processGO:003323910.010
purine nucleoside triphosphate catabolic processGO:00091462030.010
Yeast
viral life cycleGO:0019058360.010
translationGO:0006412930.010
purine nucleotide catabolic processGO:00061952110.010
Yeast

Mlh1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.087
disease of cellular proliferationDOID:1456600.087
organ system cancerDOID:005068600.071
thoracic cancerDOID:509300.033
nervous system diseaseDOID:86300.018
disease of anatomical entityDOID:700.018
breast cancerDOID:161200.016
immune system cancerDOID:006008300.012
hematologic cancerDOID:253100.012