IMP: Integrative Multi-species Prediction

Mus musculus

135 known processes

Cdx2

caudal type homeobox 2

(Aliases: Cdx-2)

Entrez: 12591
Ensembl: ENSMUSG00000029646
UniProtKB: P43241
UniProtKB: Q543L9

Process Predictions
Disease Predictions

Cdx2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
embryonic placenta development	GO:0001892	98	0.954
negative regulation of cellular response to growth factor stimulus	GO:0090288	46	0.920
trophectodermal cell differentiation	GO:0001829	21	0.902
striated muscle tissue development	GO:0014706	293	0.853
muscle tissue development	GO:0060537	308	0.838
neural tube development	GO:0021915	160	0.835
stem cell differentiation	GO:0048863	268	0.824
forebrain development	GO:0030900	302	0.796
limbic system development	GO:0021761	72	0.792
embryonic limb morphogenesis	GO:0030326	126	0.762
telencephalon development	GO:0021537	186	0.739
placenta development	GO:0001890	140	0.736
immune effector process	GO:0002252	321	0.727	Fly
stem cell development	GO:0048864	219	0.721
blastocyst formation	GO:0001825	33	0.719
developmental maturation	GO:0021700	193	0.718
embryonic appendage morphogenesis	GO:0035113	126	0.717
regulation of cardiac muscle cell proliferation	GO:0060043	23	0.705
muscle cell development	GO:0055001	133	0.686
blastocyst development	GO:0001824	80	0.672
regionalization	GO:0003002	337	0.655
leukocyte differentiation	GO:0002521	342	0.649
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.642
muscle cell differentiation	GO:0042692	261	0.629
segmentation	GO:0035282	93	0.627	Fly
lymphocyte differentiation	GO:0030098	242	0.604
limb morphogenesis	GO:0035108	149	0.603
appendage morphogenesis	GO:0035107	149	0.586
bmp signaling pathway	GO:0030509	93	0.585
dna recombination	GO:0006310	92	0.571
cell fate commitment	GO:0045165	210	0.570
dna metabolic process	GO:0006259	303	0.558
cardiac muscle cell differentiation	GO:0055007	69	0.552
pallium development	GO:0021543	120	0.551
cardiac chamber morphogenesis	GO:0003206	93	0.548
limb development	GO:0060173	166	0.525
embryonic organ morphogenesis	GO:0048562	276	0.518
t cell differentiation	GO:0030217	174	0.515
stem cell maintenance	GO:0019827	130	0.503
renal system development	GO:0072001	225	0.495
cardiocyte differentiation	GO:0035051	87	0.487
forelimb morphogenesis	GO:0035136	40	0.486
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	26	0.483
regulation of epithelial cell proliferation	GO:0050678	141	0.477
cellular lipid metabolic process	GO:0044255	323	0.473
regulation of multi organism process	GO:0043900	111	0.473	Fly
regulation of body fluid levels	GO:0050878	162	0.470
camera type eye development	GO:0043010	266	0.454
regulation of muscle tissue development	GO:1901861	97	0.449
blood vessel morphogenesis	GO:0048514	285	0.435
angiogenesis	GO:0001525	201	0.434
response to growth factor	GO:0070848	198	0.431
regulation of cellular amine metabolic process	GO:0033238	20	0.427
appendage development	GO:0048736	166	0.423
digestive tract morphogenesis	GO:0048546	147	0.419	Fly
diencephalon development	GO:0021536	63	0.400
urogenital system development	GO:0001655	261	0.396
retinoic acid metabolic process	GO:0042573	12	0.385
chromatin modification	GO:0016568	187	0.385
positive regulation of keratinocyte proliferation	GO:0010838	4	0.381
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	43	0.375
chromatin organization	GO:0006325	206	0.374
negative regulation of phosphorylation	GO:0042326	166	0.358
spermatogenesis	GO:0007283	284	0.354
jnk cascade	GO:0007254	72	0.353
organ growth	GO:0035265	117	0.346
epithelial cell proliferation	GO:0050673	174	0.342
somatic stem cell maintenance	GO:0035019	47	0.339
lymphocyte activation involved in immune response	GO:0002285	93	0.338
labyrinthine layer development	GO:0060711	49	0.338
negative regulation of phosphorus metabolic process	GO:0010563	184	0.337
intracellular receptor signaling pathway	GO:0030522	74	0.337
polarity specification of proximal distal axis	GO:0010085	2	0.335
negative regulation of cell proliferation	GO:0008285	296	0.333
lymphocyte proliferation	GO:0046651	164	0.332
sensory organ morphogenesis	GO:0090596	242	0.326
regulation of organ growth	GO:0046620	61	0.323
germ cell development	GO:0007281	185	0.322
positive regulation of epithelial cell proliferation	GO:0050679	68	0.315
regulation of cardiac muscle tissue growth	GO:0055021	26	0.312
regulation of jnk cascade	GO:0046328	62	0.311
palate development	GO:0060021	76	0.310
gland development	GO:0048732	330	0.308
somitogenesis	GO:0001756	69	0.303
regulation of heart growth	GO:0060420	31	0.301
tongue development	GO:0043586	18	0.300
cell activation involved in immune response	GO:0002263	126	0.299
regulation of neuron differentiation	GO:0045664	281	0.296
cellular response to growth factor stimulus	GO:0071363	197	0.295
cellular response to lipid	GO:0071396	145	0.294
neuroblast differentiation	GO:0014016	2	0.293
negative regulation of protein metabolic process	GO:0051248	282	0.289
head morphogenesis	GO:0060323	34	0.288
regulation of cardiac muscle tissue development	GO:0055024	31	0.281
regulation of mapk cascade	GO:0043408	248	0.278
embryonic forelimb morphogenesis	GO:0035115	32	0.276
regulation of cellular response to stress	GO:0080135	159	0.276
cellular response to acid chemical	GO:0071229	68	0.276
heart morphogenesis	GO:0003007	178	0.275
leukocyte activation involved in immune response	GO:0002366	126	0.272
cardiac muscle cell proliferation	GO:0060038	31	0.270
wound healing	GO:0042060	157	0.268
t cell activation involved in immune response	GO:0002286	43	0.267
regulation of cellular ketone metabolic process	GO:0010565	66	0.263
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.262
antimicrobial peptide production	GO:0002775	2	0.261	Fly
embryonic heart tube development	GO:0035050	65	0.261
epithelial tube morphogenesis	GO:0060562	303	0.259
cellular response to starvation	GO:0009267	57	0.255
regulation of chromosome organization	GO:0033044	83	0.251
striated muscle cell development	GO:0055002	125	0.248
negative regulation of striated muscle tissue development	GO:0045843	18	0.245
cardiac muscle tissue growth	GO:0055017	37	0.244
multicellular organismal signaling	GO:0035637	91	0.243
regulation of protein localization	GO:0032880	231	0.238
regulation of stem cell maintenance	GO:2000036	17	0.238
hindgut morphogenesis	GO:0007442	7	0.237	Fly
metanephric loop of henle development	GO:0072236	4	0.236
digestive system development	GO:0055123	200	0.235	Fly
regulation of antimicrobial humoral response	GO:0002759	3	0.234	Fly
apoptotic signaling pathway	GO:0097190	306	0.232
regulation of neuron projection development	GO:0010975	169	0.230
transdifferentiation	GO:0060290	1	0.227
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.227
retinoic acid receptor signaling pathway	GO:0048384	17	0.223
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.222
heart growth	GO:0060419	45	0.220
forebrain neuron differentiation	GO:0021879	52	0.216
cardiac chamber development	GO:0003205	108	0.214
morphogenesis of a branching epithelium	GO:0061138	193	0.212
cardiac muscle tissue development	GO:0048738	130	0.210
lipid biosynthetic process	GO:0008610	179	0.209
intestinal epithelial structure maintenance	GO:0060729	4	0.209
striated muscle cell proliferation	GO:0014855	39	0.203
cellular amino acid metabolic process	GO:0006520	103	0.203
somatotropin secreting cell differentiation	GO:0060126	4	0.202
oxidation reduction process	GO:0055114	342	0.198
regulation of bmp signaling pathway	GO:0030510	60	0.197
regulation of cellular amino acid metabolic process	GO:0006521	5	0.196
regulation of secretion	GO:0051046	274	0.196
antimicrobial peptide biosynthetic process	GO:0002777	2	0.195	Fly
pituitary gland development	GO:0021983	38	0.195
meiotic nuclear division	GO:0007126	115	0.194
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.194
mesenchymal cell development	GO:0014031	93	0.192
prostate glandular acinus development	GO:0060525	12	0.190
positive regulation of production of molecular mediator of immune response	GO:0002702	45	0.190	Fly
regulation of angiogenesis	GO:0045765	81	0.190
ear development	GO:0043583	200	0.188
regulation of stress activated mapk cascade	GO:0032872	69	0.187
cytoplasmic transport	GO:0016482	234	0.187
cardiac muscle cell development	GO:0055013	39	0.185
hexose metabolic process	GO:0019318	98	0.184
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.183
hematopoietic stem cell proliferation	GO:0071425	13	0.183
response to acid chemical	GO:0001101	111	0.182
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.180
endodermal cell fate specification	GO:0001714	4	0.179
morphogenesis of embryonic epithelium	GO:0016331	159	0.174
neuroepithelial cell differentiation	GO:0060563	37	0.174
regulation of apoptotic signaling pathway	GO:2001233	197	0.173
skeletal system development	GO:0001501	356	0.173	Mouse
stress activated protein kinase signaling cascade	GO:0031098	81	0.171
fertilization	GO:0009566	127	0.171
regulation of homeostatic process	GO:0032844	182	0.171
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.170
somatic cell dna recombination	GO:0016444	51	0.170
regulation of cell cycle	GO:0051726	281	0.168
response to extracellular stimulus	GO:0009991	127	0.167
positive regulation of cell death	GO:0010942	224	0.167
paraxial mesodermal cell differentiation	GO:0048342	2	0.165
cardiac ventricle morphogenesis	GO:0003208	50	0.164
cytokine production	GO:0001816	319	0.163
regulation of protein transport	GO:0051223	163	0.163
face morphogenesis	GO:0060325	29	0.162
cardiac cell development	GO:0055006	41	0.161
hippocampus development	GO:0021766	52	0.161
somatic diversification of immune receptors via germline recombination within a single locus	GO:0002562	51	0.159
regulation of cell migration	GO:0030334	219	0.157
positive regulation of neuron differentiation	GO:0045666	141	0.155
meiotic cell cycle	GO:0051321	122	0.154
response to starvation	GO:0042594	65	0.153
amine metabolic process	GO:0009308	45	0.153
tissue migration	GO:0090130	68	0.152
somite development	GO:0061053	81	0.152
mesoderm development	GO:0007498	100	0.152
regulation of asymmetric cell division	GO:0009786	4	0.151
cell differentiation involved in embryonic placenta development	GO:0060706	26	0.151
bone development	GO:0060348	120	0.151	Mouse
retinoid metabolic process	GO:0001523	24	0.150
cell cycle arrest	GO:0007050	37	0.150
positive regulation of programmed cell death	GO:0043068	218	0.150
respiratory system development	GO:0060541	190	0.150
alpha beta t cell differentiation	GO:0046632	69	0.149
branching morphogenesis of an epithelial tube	GO:0048754	159	0.149
skeletal system morphogenesis	GO:0048705	203	0.149	Mouse
carbohydrate metabolic process	GO:0005975	230	0.148
face development	GO:0060324	38	0.148
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.148
negative regulation of epithelial cell proliferation	GO:0050680	64	0.147
neural tube patterning	GO:0021532	43	0.147
regulation of secretion by cell	GO:1903530	249	0.146
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.145
cellular chemical homeostasis	GO:0055082	215	0.144
dendrite development	GO:0016358	115	0.143
peptidyl tyrosine phosphorylation	GO:0018108	143	0.141
regulation of response to wounding	GO:1903034	189	0.141
negative regulation of nervous system development	GO:0051961	156	0.141
positive regulation of immune effector process	GO:0002699	107	0.140	Fly
negative regulation of cellular amine metabolic process	GO:0033239	1	0.140
auditory receptor cell fate determination	GO:0042668	3	0.139
regulation of chromatin modification	GO:1903308	57	0.139
regulation of establishment of protein localization	GO:0070201	181	0.137
neuron projection guidance	GO:0097485	141	0.137
rna polymerase ii transcriptional preinitiation complex assembly	GO:0051123	3	0.136
cellular ketone metabolic process	GO:0042180	84	0.135
keratinocyte proliferation	GO:0043616	21	0.134
response to vitamin a	GO:0033189	1	0.133
pharynx development	GO:0060465	1	0.133
artery development	GO:0060840	53	0.132
morphogenesis of a branching structure	GO:0001763	203	0.131
regulation of cell motility	GO:2000145	236	0.131
respiratory tube development	GO:0030323	167	0.130
calcium ion transport	GO:0006816	159	0.128
cellular response to extracellular stimulus	GO:0031668	81	0.128
cerebellum development	GO:0021549	77	0.128
mapk cascade	GO:0000165	281	0.128
axonogenesis	GO:0007409	274	0.127
cell differentiation in spinal cord	GO:0021515	53	0.127
cardiac ventricle development	GO:0003231	83	0.125
negative regulation of cellular component organization	GO:0051129	194	0.124
multicellular organismal water homeostasis	GO:0050891	23	0.124
cell fate specification	GO:0001708	72	0.123
cellular response to organic cyclic compound	GO:0071407	87	0.123
water homeostasis	GO:0030104	27	0.123
negative regulation of protein modification process	GO:0031400	163	0.123
blood circulation	GO:0008015	195	0.122
salivary gland morphogenesis	GO:0007435	33	0.122
regulation of production of molecular mediator of immune response	GO:0002700	65	0.122	Fly
positive regulation of apoptotic process	GO:0043065	217	0.121
heart contraction	GO:0060047	93	0.121
skin development	GO:0043588	220	0.121
negative regulation of cell development	GO:0010721	169	0.121
regulation of endopeptidase activity	GO:0052548	89	0.120
homeostasis of number of cells	GO:0048872	210	0.120
regulation of cell size	GO:0008361	72	0.119
endomembrane system organization	GO:0010256	147	0.118
production of molecular mediator of immune response	GO:0002440	103	0.118	Fly
transmission of nerve impulse	GO:0019226	76	0.118
response to nutrient levels	GO:0031667	109	0.117
negative regulation of keratinocyte differentiation	GO:0045617	4	0.117
cellular response to light stimulus	GO:0071482	19	0.117
response to organonitrogen compound	GO:0010243	246	0.117
embryonic heart tube morphogenesis	GO:0003143	51	0.117
regulation of protein complex assembly	GO:0043254	83	0.115
body morphogenesis	GO:0010171	45	0.115
regulation of lipid metabolic process	GO:0019216	118	0.114
transmembrane transport	GO:0055085	412	0.113
endocrine system development	GO:0035270	98	0.111
gastrulation	GO:0007369	116	0.111	Fly
inflammatory response	GO:0006954	244	0.111
forebrain generation of neurons	GO:0021872	63	0.110
muscle fiber development	GO:0048747	76	0.110
rostrocaudal neural tube patterning	GO:0021903	12	0.110
av node cell to bundle of his cell communication	GO:0086067	2	0.110
ensheathment of neurons	GO:0007272	76	0.109
blastoderm segmentation	GO:0007350	13	0.109	Fly
negative regulation of protein phosphorylation	GO:0001933	126	0.108
negative regulation of neuron differentiation	GO:0045665	101	0.108
alpha beta t cell activation involved in immune response	GO:0002287	31	0.108
neural precursor cell proliferation	GO:0061351	121	0.107
nuclear division	GO:0000280	158	0.107
digestive tract development	GO:0048565	190	0.106	Fly
myeloid leukocyte differentiation	GO:0002573	119	0.106
positive regulation of antimicrobial peptide production	GO:0002225	1	0.106	Fly
positive regulation of lymphocyte activation	GO:0051251	140	0.105
regulation of stem cell differentiation	GO:2000736	50	0.105
positive regulation of growth	GO:0045927	104	0.104
regulation of cell projection organization	GO:0031344	206	0.104
negative regulation of cell cycle	GO:0045786	123	0.103
ameboidal type cell migration	GO:0001667	128	0.103
glycoprotein metabolic process	GO:0009100	116	0.102
t cell activation	GO:0042110	289	0.102
neuron migration	GO:0001764	122	0.102
response to inorganic substance	GO:0010035	96	0.102
regulation of mitotic cell cycle	GO:0007346	126	0.102
ossification	GO:0001503	216	0.101
paraxial mesodermal cell fate commitment	GO:0048343	2	0.101
positive regulation of organelle organization	GO:0010638	128	0.100
regulation of keratinocyte proliferation	GO:0010837	15	0.100
negative regulation of type b pancreatic cell apoptotic process	GO:2000675	3	0.099
pancreatic a cell fate commitment	GO:0003326	2	0.098
positive regulation of stem cell proliferation	GO:2000648	59	0.098
negative regulation of prostatic bud formation	GO:0060686	4	0.098
cellular ion homeostasis	GO:0006873	165	0.097
cell maturation	GO:0048469	127	0.097
single organismal cell cell adhesion	GO:0016337	131	0.096
epithelial tube formation	GO:0072175	130	0.096
cell type specific apoptotic process	GO:0097285	268	0.095
keratinocyte differentiation	GO:0030216	48	0.095
embryonic skeletal system development	GO:0048706	120	0.094
cerebral cortex development	GO:0021987	86	0.094
bone morphogenesis	GO:0060349	78	0.094	Mouse
t cell proliferation	GO:0042098	120	0.094
bundle of his development	GO:0003166	4	0.093
epithelial cell development	GO:0002064	159	0.093
embryonic eye morphogenesis	GO:0048048	29	0.093
purine containing compound metabolic process	GO:0072521	311	0.093
primary neural tube formation	GO:0014020	95	0.093
central nervous system neuron development	GO:0021954	67	0.093
covalent chromatin modification	GO:0016569	163	0.092
9 cis retinoic acid metabolic process	GO:0042905	5	0.092
embryonic digit morphogenesis	GO:0042733	56	0.092
regulation of mast cell differentiation	GO:0060375	3	0.091
central nervous system neuron differentiation	GO:0021953	162	0.091
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process	GO:2000763	1	0.091
cellular response to nutrient levels	GO:0031669	64	0.090
fat cell differentiation	GO:0045444	160	0.090
ventricular septum development	GO:0003281	42	0.090
regulation of antimicrobial peptide production	GO:0002784	1	0.089	Fly
regulation of stem cell proliferation	GO:0072091	78	0.089
cell fate determination	GO:0001709	32	0.089
regulation of cell cycle process	GO:0010564	160	0.089
cell recognition	GO:0008037	83	0.089
response to transforming growth factor beta	GO:0071559	88	0.088
hindlimb morphogenesis	GO:0035137	42	0.088
protein secretion	GO:0009306	111	0.087
regulation of organelle organization	GO:0033043	289	0.087
cd4 positive alpha beta t cell activation	GO:0035710	45	0.087
meiotic cell cycle process	GO:1903046	77	0.087
positive regulation of cell development	GO:0010720	237	0.087
positive regulation of cytokine production	GO:0001819	174	0.087
monocarboxylic acid metabolic process	GO:0032787	191	0.087
response to drug	GO:0042493	75	0.086
response to purine containing compound	GO:0014074	28	0.086
positive regulation of auditory receptor cell differentiation	GO:0045609	1	0.086
olfactory lobe development	GO:0021988	32	0.086
axon guidance	GO:0007411	141	0.085
cellular response to organonitrogen compound	GO:0071417	145	0.085
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.085
b cell activation	GO:0042113	161	0.084
foramen ovale closure	GO:0035922	1	0.084
embryonic epithelial tube formation	GO:0001838	130	0.084
reactive oxygen species metabolic process	GO:0072593	84	0.083
embryonic heart tube formation	GO:0003144	1	0.083
spemann organizer formation	GO:0060061	2	0.083
negative regulation of cellular protein metabolic process	GO:0032269	247	0.083
regulation of cell adhesion	GO:0030155	154	0.083
regulation of lymphocyte proliferation	GO:0050670	117	0.082
muscle system process	GO:0003012	141	0.082
gene silencing	GO:0016458	38	0.082
lung development	GO:0030324	164	0.081
mesodermal cell differentiation	GO:0048333	22	0.080
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.080
regulation of histone modification	GO:0031056	56	0.080
regulation of response to biotic stimulus	GO:0002831	38	0.080	Fly
glial cell development	GO:0021782	54	0.079
organelle fission	GO:0048285	170	0.079
regulation of intrinsic apoptotic signaling pathway by p53 class mediator	GO:1902253	13	0.078
protein processing	GO:0016485	163	0.078
negative regulation of phosphate metabolic process	GO:0045936	184	0.078
muscle cell apoptotic process	GO:0010657	18	0.078
response to radiation	GO:0009314	165	0.077
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	40	0.077
positive regulation of macroautophagy	GO:0016239	3	0.077
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation	GO:0003257	3	0.077
regulation of cytokine production	GO:0001817	266	0.076
multicellular organismal response to stress	GO:0033555	62	0.075
cellular homeostasis	GO:0019725	240	0.075
regulation of epithelial cell migration	GO:0010632	35	0.075
negative regulation of oxidative phosphorylation uncoupler activity	GO:2000276	2	0.074
coagulation	GO:0050817	78	0.074
odontogenesis of dentin containing tooth	GO:0042475	66	0.074
regulation of wound healing	GO:0061041	40	0.073
mesoderm formation	GO:0001707	62	0.073
cellular response to inorganic substance	GO:0071241	37	0.073
hypophysis morphogenesis	GO:0048850	3	0.073
pancreas development	GO:0031016	57	0.073
lung induction	GO:0060492	3	0.073
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.072
axial mesoderm development	GO:0048318	8	0.072
regulation of leukocyte differentiation	GO:1902105	159	0.072
tissue remodeling	GO:0048771	102	0.072
leukocyte proliferation	GO:0070661	172	0.072
positive regulation of mapk cascade	GO:0043410	170	0.072
forebrain morphogenesis	GO:0048853	17	0.071
determination of left right symmetry	GO:0007368	80	0.071
male gamete generation	GO:0048232	285	0.070
skeletal muscle organ development	GO:0060538	163	0.070
hindbrain development	GO:0030902	128	0.070
his purkinje system development	GO:0003164	4	0.070
alpha beta t cell differentiation involved in immune response	GO:0002293	30	0.070
cellular response to external stimulus	GO:0071496	88	0.070
response to oxygen levels	GO:0070482	62	0.070
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045899	2	0.070
regulation of binding	GO:0051098	111	0.069
neural crest cell development	GO:0014032	48	0.069
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	GO:2000802	1	0.069
negative regulation of growth	GO:0045926	99	0.069
mesenchyme development	GO:0060485	152	0.069
midgut development	GO:0007494	4	0.068
sensory perception of mechanical stimulus	GO:0050954	107	0.068
pancreatic pp cell differentiation	GO:0003312	2	0.068
regulation of membrane potential	GO:0042391	192	0.068
spinal cord development	GO:0021510	81	0.068
cell growth	GO:0016049	130	0.068
response to molecule of bacterial origin	GO:0002237	143	0.068
hematopoietic progenitor cell differentiation	GO:0002244	143	0.067
positive regulation of protein phosphorylation	GO:0001934	242	0.067
intrinsic apoptotic signaling pathway	GO:0097193	132	0.067
neural tube formation	GO:0001841	108	0.067
nucleoside phosphate metabolic process	GO:0006753	338	0.067
oogenesis	GO:0048477	56	0.066
ion transmembrane transport	GO:0034220	361	0.066
generation of precursor metabolites and energy	GO:0006091	103	0.066
regulation of leukocyte proliferation	GO:0070663	121	0.066
multicellular organism growth	GO:0035264	161	0.065
proteoglycan biosynthetic process	GO:0030166	20	0.065
mitral valve development	GO:0003174	4	0.065
positive regulation of stem cell differentiation	GO:2000738	23	0.064
circulatory system process	GO:0003013	197	0.064
neuronal action potential	GO:0019228	54	0.064
negative regulation of epidermal cell differentiation	GO:0045605	7	0.064
divalent inorganic cation transport	GO:0072511	178	0.064
negative regulation of gastrulation	GO:2000542	3	0.064
regulation of peptidase activity	GO:0052547	96	0.064
carbohydrate derivative catabolic process	GO:1901136	231	0.063
positive regulation of exit from mitosis	GO:0031536	1	0.063
organic cyclic compound catabolic process	GO:1901361	295	0.063
spinal cord motor neuron differentiation	GO:0021522	35	0.063
single fertilization	GO:0007338	82	0.063
positive regulation of cell adhesion	GO:0045785	80	0.063
positive regulation of muscle tissue development	GO:1901863	32	0.063
embryonic skeletal system morphogenesis	GO:0048704	91	0.062
regulation of carbohydrate metabolic process	GO:0006109	75	0.062
t cell differentiation in thymus	GO:0033077	77	0.062
epithelial cell differentiation involved in prostate gland development	GO:0060742	13	0.062
epithelial structure maintenance	GO:0010669	9	0.062
neural tube closure	GO:0001843	90	0.062
astrocyte fate commitment	GO:0060018	4	0.061
isoprenoid metabolic process	GO:0006720	29	0.061
female genitalia morphogenesis	GO:0048807	3	0.061
cellular amine metabolic process	GO:0044106	44	0.061
glucose homeostasis	GO:0042593	128	0.061
pancreatic pp cell fate commitment	GO:0003329	2	0.060
somatic recombination of immunoglobulin gene segments	GO:0016447	42	0.059
regulation of cellular component biogenesis	GO:0044087	181	0.059
semaphorin plexin signaling pathway involved in outflow tract morphogenesis	GO:0071527	1	0.059
regulation of b cell activation	GO:0050864	81	0.059
fatty acid metabolic process	GO:0006631	121	0.059
epithelial to mesenchymal transition	GO:0001837	47	0.059
hormone metabolic process	GO:0042445	86	0.059
epithelium migration	GO:0090132	63	0.058
neuromuscular process	GO:0050905	99	0.058
adaptive immune response	GO:0002250	155	0.058
cardiac right atrium morphogenesis	GO:0003213	3	0.058
glial cell differentiation	GO:0010001	131	0.058
stress activated mapk cascade	GO:0051403	80	0.058
positive regulation of hormone secretion	GO:0046887	38	0.057
tube formation	GO:0035148	140	0.057
endocrine pancreas development	GO:0031018	29	0.057
negative regulation of molecular function	GO:0044092	258	0.057
glycerolipid biosynthetic process	GO:0045017	50	0.057
brown fat cell differentiation	GO:0050873	36	0.057
macromolecule catabolic process	GO:0009057	281	0.057
regulation of protein secretion	GO:0050708	82	0.057
positive regulation of cysteine type endopeptidase activity	GO:2001056	39	0.057
divalent metal ion transport	GO:0070838	172	0.056
mitral valve morphogenesis	GO:0003183	4	0.056
multi multicellular organism process	GO:0044706	109	0.056
organic hydroxy compound biosynthetic process	GO:1901617	77	0.056
cellular response to fibroblast growth factor stimulus	GO:0044344	47	0.056
negative regulation of cytokine production	GO:0001818	84	0.056
forebrain neuron fate commitment	GO:0021877	13	0.056
cellular nitrogen compound catabolic process	GO:0044270	280	0.056
forebrain neuron development	GO:0021884	30	0.056
regulation of vasculature development	GO:1901342	88	0.056
negative regulation of proteolysis	GO:0045861	74	0.056
neural crest cell differentiation	GO:0014033	54	0.055
glucose metabolic process	GO:0006006	92	0.055
single organism cell adhesion	GO:0098602	156	0.055
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.055
neuron apoptotic process	GO:0051402	142	0.055
mesenchyme morphogenesis	GO:0072132	32	0.055
carbohydrate homeostasis	GO:0033500	128	0.055
cell adhesion	GO:0007155	329	0.055
ear morphogenesis	GO:0042471	118	0.055
thyroid stimulating hormone secreting cell differentiation	GO:0060129	4	0.054
positive regulation of secretion by cell	GO:1903532	114	0.054

Cdx2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
diabetes mellitus	DOID:9351	0.157
type 2 diabetes mellitus	DOID:9352	0.157
disease of metabolism	DOID:0014667	0.157
carbohydrate metabolism disease	DOID:0050013	0.157
glucose metabolism disease	DOID:4194	0.157
acquired metabolic disease	DOID:0060158	0.157

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