IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Hsd3b7

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

(Aliases: AI195443,BB098564)

Ensembl: ENSMUSG00000042289
Entrez: 101502
UniProtKB: Q9EQC1

Process Predictions
Disease Predictions

Hsd3b7 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cellular amide metabolic process	GO:0043603	58	0.979
oxidation reduction process	GO:0055114	342	0.970
monocarboxylic acid metabolic process	GO:0032787	191	0.954
small molecule catabolic process	GO:0044282	71	0.885
monocarboxylic acid catabolic process	GO:0072329	27	0.768
organic acid catabolic process	GO:0016054	51	0.738
fatty acid oxidation	GO:0019395	28	0.729
carboxylic acid catabolic process	GO:0046395	51	0.720
cellular modified amino acid metabolic process	GO:0006575	63	0.711
peptide metabolic process	GO:0006518	46	0.702
cellular lipid metabolic process	GO:0044255	323	0.700
short chain fatty acid catabolic process	GO:0019626	2	0.677
glutathione metabolic process	GO:0006749	16	0.649
cellular lipid catabolic process	GO:0044242	52	0.642
fatty acid metabolic process	GO:0006631	121	0.605
lipid catabolic process	GO:0016042	69	0.583
toxin catabolic process	GO:0009407	1	0.570
fatty acid catabolic process	GO:0009062	25	0.510
xenobiotic catabolic process	GO:0042178	1	0.487
neutral lipid metabolic process	GO:0006638	57	0.442
lipid biosynthetic process	GO:0008610	179	0.390
response to organic cyclic compound	GO:0014070	198	0.379
cellular amino acid metabolic process	GO:0006520	103	0.373
activation of membrane attack complex	GO:0001905	4	0.350
plasma lipoprotein particle clearance	GO:0034381	13	0.341
triglyceride metabolic process	GO:0006641	51	0.339
leukocyte mediated immunity	GO:0002443	174	0.291
acylglycerol metabolic process	GO:0006639	55	0.289
negative regulation of nitric oxide synthase biosynthetic process	GO:0051771	1	0.287
alpha amino acid metabolic process	GO:1901605	59	0.286
establishment of blood nerve barrier	GO:0008065	3	0.261
sterol metabolic process	GO:0016125	58	0.258	Mouse
regulation of phagocytosis	GO:0050764	33	0.255
response to acid chemical	GO:0001101	111	0.229
organic heteropentacyclic compound catabolic process	GO:1901377	1	0.227
carbohydrate catabolic process	GO:0016052	32	0.223
sulfur compound metabolic process	GO:0006790	100	0.217
lipid modification	GO:0030258	65	0.201
superoxide metabolic process	GO:0006801	27	0.191
positive regulation of t cell mediated cytotoxicity	GO:0001916	15	0.185
response to metal ion	GO:0010038	47	0.184
regulation of apoptotic signaling pathway	GO:2001233	197	0.184
regulation of beta amyloid clearance	GO:1900221	1	0.174
secondary metabolite catabolic process	GO:0090487	1	0.172
generation of precursor metabolites and energy	GO:0006091	103	0.168
apoptotic signaling pathway	GO:0097190	306	0.166
protein activation cascade	GO:0072376	19	0.165
alcohol metabolic process	GO:0006066	116	0.165	Mouse
organonitrogen compound catabolic process	GO:1901565	264	0.155
carbohydrate metabolic process	GO:0005975	230	0.153
male gamete generation	GO:0048232	285	0.148
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	61	0.147
glycerolipid metabolic process	GO:0046486	122	0.143
nadph regeneration	GO:0006740	2	0.143
regulation of plasma lipoprotein particle levels	GO:0097006	23	0.143
positive regulation of activation of membrane attack complex	GO:0001970	2	0.141
positive regulation of endocytosis	GO:0045807	42	0.139
regulation of lymphocyte mediated immunity	GO:0002706	84	0.137
response to oxidative stress	GO:0006979	123	0.136
lipid localization	GO:0010876	126	0.133
cofactor metabolic process	GO:0051186	80	0.132
response to reactive oxygen species	GO:0000302	56	0.126
response to molecule of bacterial origin	GO:0002237	143	0.121
organic hydroxy compound catabolic process	GO:1901616	25	0.118
positive regulation of phagocytosis	GO:0050766	26	0.116
response to extracellular stimulus	GO:0009991	127	0.115
negative regulation of cellular protein metabolic process	GO:0032269	247	0.110
spermatogenesis	GO:0007283	284	0.110
response to steroid hormone	GO:0048545	56	0.102
benzene containing compound metabolic process	GO:0042537	5	0.102
negative regulation of molecular function	GO:0044092	258	0.098
multicellular organismal homeostasis	GO:0048871	164	0.097
regulation of peptidase activity	GO:0052547	96	0.096
positive regulation of immune effector process	GO:0002699	107	0.095
cholesterol storage	GO:0010878	4	0.092
aflatoxin catabolic process	GO:0046223	1	0.089
regulation of phospholipid catabolic process	GO:0060696	2	0.087
reactive nitrogen species metabolic process	GO:2001057	0	0.084
terpenoid metabolic process	GO:0006721	25	0.083
cellular response to hormone stimulus	GO:0032870	150	0.082
lipid oxidation	GO:0034440	29	0.081
sterol homeostasis	GO:0055092	45	0.079
leukocyte mediated cytotoxicity	GO:0001909	62	0.078
immune effector process	GO:0002252	321	0.078
positive regulation of leukocyte mediated cytotoxicity	GO:0001912	31	0.077
organic hydroxy compound metabolic process	GO:1901615	203	0.075	Mouse
regulation of leukocyte mediated immunity	GO:0002703	104	0.075
acylglycerol biosynthetic process	GO:0046463	18	0.073
organic cyclic compound catabolic process	GO:1901361	295	0.073
response to phenylpropanoid	GO:0080184	22	0.072
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.071
coagulation	GO:0050817	78	0.070
heart morphogenesis	GO:0003007	178	0.066
reactive oxygen species metabolic process	GO:0072593	84	0.066
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.065
glucan metabolic process	GO:0044042	32	0.065
regulation of endocytosis	GO:0030100	69	0.064
cellular response to hexose stimulus	GO:0071331	47	0.064
reverse cholesterol transport	GO:0043691	6	0.064
cell adhesion	GO:0007155	329	0.063
cholesterol catabolic process	GO:0006707	5	0.063
toxin metabolic process	GO:0009404	5	0.063
response to lipopolysaccharide	GO:0032496	128	0.062
cellular response to molecule of bacterial origin	GO:0071219	83	0.062
monocyte chemotactic protein 1 production	GO:0071605	1	0.062
response to peptide hormone	GO:0043434	127	0.062
phagocytosis	GO:0006909	66	0.061
cellular response to glucose stimulus	GO:0071333	45	0.060
regulation of endopeptidase activity	GO:0052548	89	0.058
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.058
response to inorganic substance	GO:0010035	96	0.058
cellular chemical homeostasis	GO:0055082	215	0.057
cellular homeostasis	GO:0019725	240	0.056
response to hydroperoxide	GO:0033194	6	0.056
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.056
lymphocyte mediated immunity	GO:0002449	139	0.056
cellular ketone metabolic process	GO:0042180	84	0.055
sterol catabolic process	GO:0016127	5	0.055
regulation of triglyceride biosynthetic process	GO:0010866	10	0.054
regulation of protein activation cascade	GO:2000257	7	0.054
response to alcohol	GO:0097305	48	0.053
icosanoid metabolic process	GO:0006690	33	0.053
positive regulation of lymphocyte mediated immunity	GO:0002708	62	0.052
reactive oxygen species biosynthetic process	GO:1903409	8	0.052
cellular response to oxidative stress	GO:0034599	76	0.051
response to monosaccharide	GO:0034284	67	0.050
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.050
protein processing	GO:0016485	163	0.050
cellular response to monosaccharide stimulus	GO:0071326	47	0.050
positive regulation of mapk cascade	GO:0043410	170	0.049
adaptive immune response	GO:0002250	155	0.049
regulation of kinase activity	GO:0043549	249	0.048
regulation of protein kinase activity	GO:0045859	232	0.047
organ regeneration	GO:0031100	2	0.047
negative regulation of cell proliferation	GO:0008285	296	0.047
response to testosterone	GO:0033574	3	0.047
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.047
response to peptide	GO:1901652	136	0.047
negative regulation of monocyte chemotactic protein 1 production	GO:0071638	1	0.047
skeletal system development	GO:0001501	356	0.046
intracellular cholesterol transport	GO:0032367	3	0.046
positive regulation of lipid storage	GO:0010884	10	0.046
endocytosis	GO:0006897	168	0.045
regulation of hormone levels	GO:0010817	211	0.045
vitamin metabolic process	GO:0006766	23	0.045
aspartate family amino acid metabolic process	GO:0009066	10	0.044
hexose catabolic process	GO:0019320	3	0.044
regulation of lipid transport	GO:0032368	36	0.044
response to nutrient levels	GO:0031667	109	0.043
liver development	GO:0001889	66	0.043
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.043
cholesterol homeostasis	GO:0042632	44	0.043
hepaticobiliary system development	GO:0061008	67	0.042
regulation of vesicle mediated transport	GO:0060627	139	0.042
intrinsic apoptotic signaling pathway	GO:0097193	132	0.041
cellular response to lipopolysaccharide	GO:0071222	77	0.041
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.040
monosaccharide metabolic process	GO:0005996	106	0.040
peripheral nervous system development	GO:0007422	53	0.040
cellular response to organic cyclic compound	GO:0071407	87	0.040
epithelial cell proliferation	GO:0050673	174	0.040
regulation of cell activation	GO:0050865	289	0.039
regulation of phosphatidylcholine catabolic process	GO:0010899	2	0.039
female meiosis chromosome segregation	GO:0016321	1	0.039
cellular response to carbohydrate stimulus	GO:0071322	50	0.039
regulation of complement activation	GO:0030449	7	0.038
positive regulation of sterol transport	GO:0032373	9	0.038
positive regulation of mitochondrial calcium ion concentration	GO:0051561	3	0.038
regulation of adaptive immune response	GO:0002819	90	0.038
small molecule biosynthetic process	GO:0044283	132	0.038
sphingolipid metabolic process	GO:0006665	45	0.038
negative regulation of proteolysis	GO:0045861	74	0.037
urogenital system development	GO:0001655	261	0.037
positive regulation of apoptotic cell clearance	GO:2000427	3	0.037
positive regulation of protein activation cascade	GO:2000259	2	0.037
lung development	GO:0030324	164	0.037
low density lipoprotein particle clearance	GO:0034383	8	0.037
anatomical structure homeostasis	GO:0060249	145	0.037
positive regulation of cholesterol storage	GO:0010886	3	0.036
t cell activation	GO:0042110	289	0.036
fatty acid derivative metabolic process	GO:1901568	33	0.035
sterol transport	GO:0015918	38	0.035
triglyceride biosynthetic process	GO:0019432	17	0.035
short chain fatty acid metabolic process	GO:0046459	6	0.035
regulation of cholesterol metabolic process	GO:0090181	14	0.035
beta amyloid clearance	GO:0097242	2	0.035
isoprenoid metabolic process	GO:0006720	29	0.034
t cell differentiation	GO:0030217	174	0.033
alcohol catabolic process	GO:0046164	16	0.033
maintenance of location	GO:0051235	89	0.033
cholesterol metabolic process	GO:0008203	56	0.032	Mouse
extrinsic apoptotic signaling pathway	GO:0097191	126	0.032
response to oxygen radical	GO:0000305	16	0.032
hydrogen peroxide catabolic process	GO:0042744	5	0.032
spermatid differentiation	GO:0048515	115	0.032
protein maturation	GO:0051604	176	0.032
very long chain fatty acid metabolic process	GO:0000038	8	0.032
regulation of cellular catabolic process	GO:0031329	242	0.032
multicellular organism growth	GO:0035264	161	0.032
cellular response to oxygen radical	GO:0071450	14	0.032
gland development	GO:0048732	330	0.032
regulation of leukocyte mediated cytotoxicity	GO:0001910	38	0.031
positive regulation of protein modification process	GO:0031401	299	0.031
glycosylation	GO:0070085	62	0.031
monosaccharide biosynthetic process	GO:0046364	44	0.031
regulation of coagulation	GO:0050818	31	0.031
positive regulation of protein phosphorylation	GO:0001934	242	0.031
innate immune response	GO:0045087	157	0.031
cellular glucose homeostasis	GO:0001678	52	0.030
lymphocyte differentiation	GO:0030098	242	0.030
lipid storage	GO:0019915	36	0.030
posttranscriptional regulation of gene expression	GO:0010608	155	0.030
blood coagulation	GO:0007596	76	0.030
negative regulation of protein metabolic process	GO:0051248	282	0.029
hydrogen peroxide metabolic process	GO:0042743	16	0.029
peptidyl tyrosine modification	GO:0018212	145	0.029
nucleocytoplasmic transport	GO:0006913	139	0.029
positive regulation of coagulation	GO:0050820	13	0.028
steroid metabolic process	GO:0008202	119	0.028	Mouse
pentose phosphate shunt	GO:0006098	2	0.028
response to stilbenoid	GO:0035634	22	0.028
aflatoxin metabolic process	GO:0046222	1	0.027
coenzyme metabolic process	GO:0006732	52	0.027
positive regulation of steroid biosynthetic process	GO:0010893	4	0.027
cellular carbohydrate catabolic process	GO:0044275	15	0.027
epithelial cell development	GO:0002064	159	0.027
regulation of body fluid levels	GO:0050878	162	0.027
positive regulation of lipid biosynthetic process	GO:0046889	18	0.026
cell killing	GO:0001906	67	0.026
energy derivation by oxidation of organic compounds	GO:0015980	77	0.026
positive regulation of apoptotic process	GO:0043065	217	0.026
iron ion transport	GO:0006826	17	0.026
protein oligomerization	GO:0051259	67	0.026
t cell mediated cytotoxicity	GO:0001913	26	0.026
cellular amine metabolic process	GO:0044106	44	0.026
positive regulation of myeloid leukocyte mediated immunity	GO:0002888	14	0.025
cellular response to cadmium ion	GO:0071276	3	0.025
phospholipid transfer to membrane	GO:0006649	2	0.025
regulation of homeostatic process	GO:0032844	182	0.025
amide transport	GO:0042886	138	0.025
carbohydrate homeostasis	GO:0033500	128	0.025
tumor necrosis factor production	GO:0032640	50	0.025
response to organonitrogen compound	GO:0010243	246	0.025
negative regulation of peroxidase activity	GO:2000469	1	0.024
positive regulation of response to wounding	GO:1903036	66	0.024
neuromuscular process controlling balance	GO:0050885	59	0.024
regulation of protein stability	GO:0031647	52	0.024
retina homeostasis	GO:0001895	23	0.024
secondary metabolic process	GO:0019748	18	0.024
regulation of protein maturation	GO:1903317	96	0.024
regulation of proteolysis	GO:0030162	164	0.024
glucose catabolic process	GO:0006007	3	0.023
defense response to bacterium	GO:0042742	119	0.023
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway	GO:0002484	3	0.023
wound healing	GO:0042060	157	0.023
macromolecule glycosylation	GO:0043413	55	0.023
positive regulation of phagocytosis engulfment	GO:0060100	3	0.023
prostaglandin metabolic process	GO:0006693	11	0.023
response to superoxide	GO:0000303	16	0.023
regulation of transferase activity	GO:0051338	263	0.022
glucose homeostasis	GO:0042593	128	0.022
phospholipid catabolic process	GO:0009395	5	0.022
gonad development	GO:0008406	141	0.022
cellular response to testosterone stimulus	GO:0071394	1	0.022
regulation of removal of superoxide radicals	GO:2000121	4	0.022
regulation of cellular ketone metabolic process	GO:0010565	66	0.022
regulation of peptide transport	GO:0090087	91	0.022
cell activation involved in immune response	GO:0002263	126	0.022
peptidyl amino acid modification	GO:0018193	336	0.021
cellular response to food	GO:0071240	1	0.021
kidney development	GO:0001822	213	0.021
regulation of tumor necrosis factor superfamily cytokine production	GO:1903555	50	0.021
cellular response to extracellular stimulus	GO:0031668	81	0.021
positive regulation of nf kappab transcription factor activity	GO:0051092	30	0.021
lymphocyte activation involved in immune response	GO:0002285	93	0.020
nuclear transport	GO:0051169	139	0.020
regulation of blood coagulation	GO:0030193	28	0.020
dicarboxylic acid metabolic process	GO:0043648	18	0.020
protein glycosylation	GO:0006486	55	0.020
cellular protein catabolic process	GO:0044257	155	0.020
amine metabolic process	GO:0009308	45	0.020
regulation of triglyceride metabolic process	GO:0090207	17	0.020
respiratory system development	GO:0060541	190	0.020
cellular response to biotic stimulus	GO:0071216	92	0.020
development of primary sexual characteristics	GO:0045137	143	0.020
intracellular sterol transport	GO:0032366	3	0.020
skeletal system morphogenesis	GO:0048705	203	0.019
cellular response to bacterial lipopeptide	GO:0071221	3	0.019
cellular alcohol metabolic process	GO:0044107	3	0.019
glycerolipid catabolic process	GO:0046503	16	0.019
glycolytic process	GO:0006096	20	0.019
negative regulation of insulin secretion involved in cellular response to glucose stimulus	GO:0061179	4	0.019
mitochondrial calcium ion homeostasis	GO:0051560	7	0.019
negative regulation of endopeptidase activity	GO:0010951	44	0.019
tumor necrosis factor superfamily cytokine production	GO:0071706	51	0.019
mapk cascade	GO:0000165	281	0.019
cellular amino acid catabolic process	GO:0009063	25	0.018
ceramide metabolic process	GO:0006672	31	0.018
regulation of defense response	GO:0031347	233	0.018
regulation of insulin secretion involved in cellular response to glucose stimulus	GO:0061178	31	0.018
regulation of lymphocyte activation	GO:0051249	240	0.018
positive regulation of proteolysis	GO:0045862	85	0.018
cation transport	GO:0006812	399	0.018
cellular response to starvation	GO:0009267	57	0.018
male sex differentiation	GO:0046661	109	0.018
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	31	0.018
membrane lipid biosynthetic process	GO:0046467	32	0.018
acute inflammatory response to antigenic stimulus	GO:0002438	12	0.018
endoplasmic reticulum calcium ion homeostasis	GO:0032469	11	0.018
response to hydrogen peroxide	GO:0042542	32	0.018
positive regulation of complement activation	GO:0045917	2	0.018
positive regulation of t cell activation	GO:0050870	101	0.017
production of molecular mediator of immune response	GO:0002440	103	0.017
cellular response to hydroperoxide	GO:0071447	4	0.017
positive regulation of lipid transport	GO:0032370	22	0.017
carbohydrate derivative biosynthetic process	GO:1901137	183	0.017
lipoprotein transport	GO:0042953	7	0.017
protein folding	GO:0006457	28	0.017
intracellular lipid transport	GO:0032365	3	0.017
regulation of type ii hypersensitivity	GO:0002892	4	0.017
lysosome organization	GO:0007040	21	0.017
drug catabolic process	GO:0042737	2	0.017
regulation of t cell activation	GO:0050863	170	0.017
regulation of protein targeting	GO:1903533	61	0.017
leukocyte proliferation	GO:0070661	172	0.017
cation homeostasis	GO:0055080	212	0.017
pyruvate metabolic process	GO:0006090	28	0.017
glutamine family amino acid biosynthetic process	GO:0009084	2	0.017
single fertilization	GO:0007338	82	0.017
cellular amino acid biosynthetic process	GO:0008652	22	0.017
response to epidermal growth factor	GO:0070849	4	0.017
regeneration	GO:0031099	38	0.016
macromolecule catabolic process	GO:0009057	281	0.016
negative regulation of immune system process	GO:0002683	209	0.016
regulation of b cell mediated immunity	GO:0002712	37	0.016
aromatic compound catabolic process	GO:0019439	286	0.016
rna interference	GO:0016246	2	0.016
response to xenobiotic stimulus	GO:0009410	13	0.016
protein tetramerization	GO:0051262	23	0.016
negative regulation of transferase activity	GO:0051348	85	0.016
organic heteropentacyclic compound metabolic process	GO:1901376	1	0.016
negative regulation of kinase activity	GO:0033673	81	0.016
vitamin d3 metabolic process	GO:0070640	3	0.016
adiponectin activated signaling pathway	GO:0033211	4	0.016
positive regulation of transferase activity	GO:0051347	167	0.016
insulin secretion involved in cellular response to glucose stimulus	GO:0035773	36	0.016
cholesterol import	GO:0070508	2	0.016
gliogenesis	GO:0042063	141	0.016
regulation of immunoglobulin mediated immune response	GO:0002889	37	0.016
renal system development	GO:0072001	225	0.016
inclusion body assembly	GO:0070841	3	0.016
protein localization to organelle	GO:0033365	185	0.016
angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure	GO:0001998	3	0.016
negative regulation of protein processing	GO:0010955	79	0.016
regulation of peroxidase activity	GO:2000468	1	0.016
dopamine catabolic process	GO:0042420	4	0.016
tricarboxylic acid metabolic process	GO:0072350	5	0.016
hexose metabolic process	GO:0019318	98	0.015
response to nitrosative stress	GO:0051409	1	0.015
pyridine containing compound metabolic process	GO:0072524	14	0.015
glycogen metabolic process	GO:0005977	32	0.015
cellular response to lipid	GO:0071396	145	0.015
positive regulation of triglyceride metabolic process	GO:0090208	9	0.015
cellular glucan metabolic process	GO:0006073	32	0.015
positive regulation of adaptive immune response	GO:0002821	61	0.015
sterol transmembrane transport	GO:0035382	2	0.015
cell recognition	GO:0008037	83	0.015
striated muscle myosin thick filament assembly	GO:0071688	1	0.015
regulation of protein serine threonine kinase activity	GO:0071900	157	0.015
negative regulation of oxidoreductase activity	GO:0051354	4	0.015
nuclear import	GO:0051170	95	0.015
complement activation	GO:0006956	16	0.015
membrane depolarization	GO:0051899	64	0.015
dna metabolic process	GO:0006259	303	0.015
positive regulation of lymphocyte activation	GO:0051251	140	0.015
secondary alcohol metabolic process	GO:1902652	3	0.015
energy reserve metabolic process	GO:0006112	39	0.015
response to endoplasmic reticulum stress	GO:0034976	53	0.015
cellular response to cytokine stimulus	GO:0071345	189	0.015
organonitrogen compound biosynthetic process	GO:1901566	192	0.014
fat soluble vitamin biosynthetic process	GO:0042362	4	0.014
myosin filament assembly	GO:0031034	2	0.014
multi multicellular organism process	GO:0044706	109	0.014
regulation of cellular amine metabolic process	GO:0033238	20	0.014
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	61	0.014
hatching	GO:0035188	4	0.014
antigen processing and presentation of endogenous peptide antigen via mhc class i	GO:0019885	3	0.014
positive regulation of cholesterol transport	GO:0032376	9	0.014
removal of superoxide radicals	GO:0019430	12	0.014
cellular response to superoxide	GO:0071451	14	0.014
diterpenoid metabolic process	GO:0016101	24	0.014
respiratory tube development	GO:0030323	167	0.014
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.014
negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis	GO:2000151	1	0.014
t cell mediated immunity	GO:0002456	50	0.014
positive regulation of cell death	GO:0010942	224	0.014
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.014
striated muscle tissue development	GO:0014706	293	0.014
stem cell differentiation	GO:0048863	268	0.014
positive regulation of b cell mediated immunity	GO:0002714	26	0.014
cellular response to epidermal growth factor stimulus	GO:0071364	4	0.014
cholesterol transport	GO:0030301	38	0.014
negative regulation of protein maturation	GO:1903318	79	0.014
hormone metabolic process	GO:0042445	86	0.014
axonogenesis	GO:0007409	274	0.014
palate development	GO:0060021	76	0.014
drug metabolic process	GO:0017144	4	0.014
cellular response to organonitrogen compound	GO:0071417	145	0.014
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.013
positive regulation of protein localization to cell surface	GO:2000010	2	0.013
regulation of hypersensitivity	GO:0002883	10	0.013
transition metal ion transport	GO:0000041	38	0.013
response to temperature stimulus	GO:0009266	55	0.013
positive regulation of kinase activity	GO:0033674	155	0.013
fibrinolysis	GO:0042730	3	0.013
cellular metal ion homeostasis	GO:0006875	151	0.013
regulation of t cell mediated cytotoxicity	GO:0001914	18	0.013
divalent inorganic cation transport	GO:0072511	178	0.013
cellular respiration	GO:0045333	38	0.013
response to heat	GO:0009408	27	0.013
regulation of lipid metabolic process	GO:0019216	118	0.013
bone resorption	GO:0045453	38	0.013
regulation of lipid biosynthetic process	GO:0046890	54	0.013
tissue homeostasis	GO:0001894	115	0.013
peroxisome organization	GO:0007031	7	0.013
positive regulation of intrinsic apoptotic signaling pathway	GO:2001244	25	0.013
heme metabolic process	GO:0042168	16	0.013
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.013
glycoprotein biosynthetic process	GO:0009101	89	0.013
canonical wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development	GO:0061310	1	0.013
regulation of protein processing	GO:0070613	96	0.013
sphingolipid biosynthetic process	GO:0030148	26	0.013
pyridine nucleotide metabolic process	GO:0019362	12	0.013
positive regulation of inflammatory response to antigenic stimulus	GO:0002863	11	0.013
intracellular protein transport	GO:0006886	204	0.013
positive regulation of lipid metabolic process	GO:0045834	40	0.013
cytokine production involved in immune response	GO:0002367	34	0.013
inflammatory response to antigenic stimulus	GO:0002437	30	0.012
regulation of cellular amino acid metabolic process	GO:0006521	5	0.012
regulation of nucleocytoplasmic transport	GO:0046822	73	0.012
nitric oxide metabolic process	GO:0046209	25	0.012
cell proliferation in external granule layer	GO:0021924	10	0.012
acute inflammatory response	GO:0002526	41	0.012
neutral lipid biosynthetic process	GO:0046460	18	0.012
lytic vacuole organization	GO:0080171	21	0.012
phospholipid transport	GO:0015914	21	0.012
sperm motility	GO:0030317	47	0.012
negative regulation of cellular amide metabolic process	GO:0034249	4	0.012
porphyrin containing compound metabolic process	GO:0006778	22	0.012
calcitriol biosynthetic process from calciol	GO:0036378	3	0.012
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis	GO:2000162	1	0.012
regulation of intracellular transport	GO:0032386	159	0.012
planar cell polarity pathway involved in pericardium morphogenesis	GO:0061354	2	0.012
plasma lipoprotein particle organization	GO:0071827	11	0.012
response to oxygen levels	GO:0070482	62	0.012
regulation of monocyte chemotactic protein 1 production	GO:0071637	1	0.012
cellular response to external stimulus	GO:0071496	88	0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.012
citrulline metabolic process	GO:0000052	3	0.012
nadp metabolic process	GO:0006739	6	0.012
positive regulation of programmed cell death	GO:0043068	218	0.012
muscle tissue development	GO:0060537	308	0.012
negative regulation of platelet derived growth factor receptor beta signaling pathway	GO:2000587	2	0.012

Hsd3b7 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
inherited metabolic disorder	DOID:655	0.961
disease of metabolism	DOID:0014667	0.961
sensory system disease	DOID:0050155	0.234
eye disease	DOID:5614	0.234
disease of anatomical entity	DOID:7	0.234
eye and adnexa disease	DOID:1492	0.234
nervous system disease	DOID:863	0.234
immune system disease	DOID:2914	0.161
lipid metabolism disorder	DOID:3146	0.111
hemolytic anemia	DOID:583	0.061
hemolytic uremic syndrome	DOID:12554	0.061
hematopoietic system disease	DOID:74	0.061
normocytic anemia	DOID:720	0.061
anemia	DOID:2355	0.061
retinal disease	DOID:5679	0.054
lipid storage disease	DOID:9455	0.050
lysosomal storage disease	DOID:3211	0.050
central nervous system disease	DOID:331	0.031
macular degeneration	DOID:4448	0.030
retinal degeneration	DOID:8466	0.030
age related macular degeneration	DOID:10871	0.030
degeneration of macula and posterior pole	DOID:2007	0.030
brain disease	DOID:936	0.024
electroclinical syndrome	DOID:0050701	0.021
epilepsy syndrome	DOID:1826	0.021
neuronal ceroid lipofuscinosis	DOID:14503	0.019
cardiovascular system disease	DOID:1287	0.018
connective tissue disease	DOID:65	0.014
musculoskeletal system disease	DOID:17	0.014
bone disease	DOID:0080001	0.014
variable age at onset electroclinical syndrome	DOID:0050706	0.014
progressive myoclonus epilepsy	DOID:891	0.013

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