Mus musculus

70 known processes

Lgmn

legumain

(Aliases: Prsc1,AEP,AI746452,AU022324)

Lgmn biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
ceramide metabolic processGO:0006672310.663
sphingolipid metabolic processGO:0006665450.513
sphingolipid catabolic processGO:003014970.468
cellular response to thyroid hormone stimulusGO:009706710.416
membrane lipid metabolic processGO:0006643530.334
membrane lipid catabolic processGO:004646680.323
glycolipid metabolic processGO:0006664250.215
lipid storageGO:0019915360.209
cellular lipid metabolic processGO:00442553230.170
glycosphingolipid catabolic processGO:004647950.161
ceramide biosynthetic processGO:0046513200.154
vacuole organizationGO:0007033380.136
protein catabolic processGO:00301632210.129
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.123
glycolipid catabolic processGO:001937750.117
adaptive immune responseGO:00022501550.113
cell adhesionGO:00071553290.110
sphingosine metabolic processGO:000667040.109
organelle assemblyGO:00709251770.102
organonitrogen compound catabolic processGO:19015652640.099
regulation of blood pressureGO:0008217930.096
angiogenesisGO:00015252010.096
regulation of apoptotic signaling pathwayGO:20012331970.093
cellular lipid catabolic processGO:0044242520.090
regulation of clathrin mediated endocytosisGO:200036940.087
peptide metabolic processGO:0006518460.087
regulation of peptidase activityGO:0052547960.083
regulation of cell motilityGO:20001452360.083
cellular amino acid metabolic processGO:00065201030.082
inflammatory responseGO:00069542440.077
male gamete generationGO:00482322850.073
cellular response to hormone stimulusGO:00328701500.073
response to organic cyclic compoundGO:00140701980.071
leukocyte mediated immunityGO:00024431740.068
cytoplasmic transportGO:00164822340.068
lysosome organizationGO:0007040210.068
apoptotic signaling pathwayGO:00971903060.067
leukocyte mediated cytotoxicityGO:0001909620.065
regulation of actin cytoskeleton organizationGO:0032956840.064
multi multicellular organism processGO:00447061090.064
oxidation reduction processGO:00551143420.063
cellular ketone metabolic processGO:0042180840.063
protein processingGO:00164851630.062
organelle fusionGO:0048284280.061
neuronal action potentialGO:0019228540.060
sphingolipid biosynthetic processGO:0030148260.058
response to thyroid hormoneGO:009706620.057
response to monosaccharideGO:0034284670.057
positive regulation of lymphocyte activationGO:00512511400.054
maintenance of locationGO:0051235890.054
lipid biosynthetic processGO:00086101790.053
calcium ion transportGO:00068161590.053
regulation of protein localizationGO:00328802310.052
decidualizationGO:0046697100.052
muscle tissue developmentGO:00605373080.051
positive regulation of t cell activationGO:00508701010.049
carbohydrate derivative catabolic processGO:19011362310.049
chemotaxisGO:00069352470.049
positive regulation of programmed cell deathGO:00430682180.048
liposaccharide metabolic processGO:1903509270.048
multicellular organismal signalingGO:0035637910.047
oligosaccharide catabolic processGO:000931320.047
positive regulation of apoptotic signaling pathwayGO:2001235950.047
multicellular organismal macromolecule metabolic processGO:0044259190.046
endocytosisGO:00068971680.046
regulation of cell activationGO:00508652890.045
extracellular matrix organizationGO:00301981470.044
positive regulation of cell migrationGO:00303351090.044
protein polymerizationGO:0051258570.044
cellular amine metabolic processGO:0044106440.043
positive regulation of cell activationGO:00508671580.043
t cell mediated cytotoxicityGO:0001913260.043
ceramide catabolic processGO:004651470.043
cell chemotaxisGO:0060326810.043
cellular protein catabolic processGO:00442571550.042
oligosaccharide metabolic processGO:0009311110.042
kidney developmentGO:00018222130.042
axonogenesisGO:00074092740.042
membrane lipid biosynthetic processGO:0046467320.041
phagolysosome assemblyGO:000184530.041
hormone metabolic processGO:0042445860.041
ion transmembrane transportGO:00342203610.041
maternal process involved in female pregnancyGO:0060135320.041
cell substrate adhesionGO:00315891300.041
barbed end actin filament cappingGO:005101660.041
multicellular organismal homeostasisGO:00488711640.041
regulation of membrane potentialGO:00423911920.040
positive regulation of inflammatory responseGO:0050729470.040
monocarboxylic acid metabolic processGO:00327871910.040
renal system developmentGO:00720012250.040
protein maturationGO:00516041760.039
regulation of hormone levelsGO:00108172110.038
myelinationGO:0042552740.038
cellular chemical homeostasisGO:00550822150.038
positive regulation of proteolysisGO:0045862850.038
membrane protein proteolysisGO:0033619100.037
regulation of transferase activityGO:00513382630.037
muscle cell differentiationGO:00426922610.036
multicellular organismal metabolic processGO:0044236280.036
cellular macromolecule catabolic processGO:00442652060.035
cell killingGO:0001906670.035
multicellular organismal macromolecule catabolic processGO:004426610.035
response to interleukin 4GO:0070670230.035
glycosylceramide metabolic processGO:000667740.034
collagen catabolic processGO:003057460.034
regulation of anatomical structure sizeGO:00900661780.034
sphingoid metabolic processGO:004651950.034
collagen metabolic processGO:0032963170.034
lytic vacuole organizationGO:0080171210.034
male sex differentiationGO:00466611090.033
regulation of proteolysisGO:00301621640.033
protein autoprocessingGO:001654020.032
morphogenesis of a branching structureGO:00017632030.032
regulation of system processGO:00440572000.032
positive regulation of mapk cascadeGO:00434101700.031
actin filament organizationGO:00070151130.031
negative regulation of protein metabolic processGO:00512482820.031
response to peptide hormoneGO:00434341270.031
positive regulation of cellular amine metabolic processGO:003324050.030
small molecule biosynthetic processGO:00442831320.030
amine metabolic processGO:0009308450.030
regulation of response to woundingGO:19030341890.030
cellular amide metabolic processGO:0043603580.030
response to peptideGO:19016521360.030
meiotic cell cycleGO:00513211220.029
carbohydrate metabolic processGO:00059752300.029
reactive oxygen species biosynthetic processGO:190340980.029
regulation of epithelial cell proliferationGO:00506781410.029
response to organonitrogen compoundGO:00102432460.028
glial cell differentiationGO:00100011310.028
phagosome maturationGO:009038240.028
positive regulation of cell motilityGO:20001471160.028
transmission of nerve impulseGO:0019226760.028
gliogenesisGO:00420631410.028
adult behaviorGO:00305341350.027
actin cytoskeleton organizationGO:00300362200.027
blood vessel morphogenesisGO:00485142850.027
regulation of blood circulationGO:1903522930.027
divalent inorganic cation transportGO:00725111780.027
glycosphingolipid metabolic processGO:0006687180.026
organic anion transportGO:00157111370.026
carboxylic acid catabolic processGO:0046395510.026
male gonad developmentGO:0008584880.026
bone remodelingGO:0046849530.026
regulation of protein transportGO:00512231630.026
epithelium migrationGO:0090132630.026
t cell mediated immunityGO:0002456500.026
developmental maturationGO:00217001930.026
epithelial cell proliferationGO:00506731740.026
nucleotide metabolic processGO:00091173320.025
regulation of chemotaxisGO:0050920530.025
small molecule catabolic processGO:0044282710.025
regulation of organelle organizationGO:00330432890.025
positive regulation of cellular amino acid metabolic processGO:004576430.025
protein lipid complex subunit organizationGO:0071825120.025
positive regulation of cell adhesionGO:0045785800.025
arp2 3 complex mediated actin nucleationGO:003431430.024
maternal placenta developmentGO:0001893200.024
striated muscle tissue developmentGO:00147062930.024
regulation of lymphocyte activationGO:00512492400.024
response to extracellular stimulusGO:00099911270.024
positive regulation of endocytosisGO:0045807420.023
locomotory behaviorGO:00076261950.023
lipid localizationGO:00108761260.023
ensheathment of neuronsGO:0007272760.022
tissue migrationGO:0090130680.022
nuclear importGO:0051170950.022
neuron projection guidanceGO:00974851410.022
regulation of mapk cascadeGO:00434082480.022
molting cycleGO:0042303900.022
positive regulation of cell deathGO:00109422240.022
cellular component assembly involved in morphogenesisGO:00109271390.022
placenta developmentGO:00018901400.022
cellular response to external stimulusGO:0071496880.022
sensory system developmentGO:004888030.021
regulation of angiotensin levels in bloodGO:000200240.021
cell recognitionGO:0008037830.021
carbohydrate catabolic processGO:0016052320.021
carboxylic acid transportGO:00469421000.021
cellularizationGO:000734910.021
regulation of cell migrationGO:00303342190.021
negative regulation of protein complex disassemblyGO:0043242220.021
action potentialGO:0001508780.021
response to amineGO:0014075160.021
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.020
regulation of endocytosisGO:0030100690.020
fertilizationGO:00095661270.020
t cell activationGO:00421102890.020
epithelial tube branching involved in lung morphogenesisGO:0060441280.020
positive regulation of homeostatic processGO:0032846640.020
lipid catabolic processGO:0016042690.020
negative regulation of intracellular signal transductionGO:19025321670.020
establishment of planar polarityGO:0001736280.020
leukocyte chemotaxisGO:0030595690.020
vesicle organizationGO:0016050600.020
anatomical structure maturationGO:0071695490.020
regulation of hydrolase activityGO:00513362460.019
actin polymerization or depolymerizationGO:0008154540.019
membrane organizationGO:00610242450.019
response to nutrient levelsGO:00316671090.019
stem cell differentiationGO:00488632680.019
positive regulation of membrane protein ectodomain proteolysisGO:005104430.019
lateral line system developmentGO:004892510.019
metanephric glomerular visceral epithelial cell developmentGO:007224920.019
epidermis developmentGO:00085441870.019
protein oligomerizationGO:0051259670.019
plasma lipoprotein particle remodelingGO:003436960.019
lung morphogenesisGO:0060425500.019
peptide hormone processingGO:001648690.019
tissue homeostasisGO:00018941150.019
glycosyl compound catabolic processGO:19016582060.019
astrocyte cell migrationGO:004361530.019
response to acid chemicalGO:00011011110.019
ameboidal type cell migrationGO:00016671280.018
regulation of cytoskeleton organizationGO:00514931220.018
positive regulation of protein modification processGO:00314012990.018
carboxylic acid biosynthetic processGO:0046394860.018
single organism cell adhesionGO:00986021560.018
sulfur compound metabolic processGO:00067901000.018
organic acid transportGO:00158491010.018
organic acid catabolic processGO:0016054510.018
striated muscle cell developmentGO:00550021250.018
carbohydrate homeostasisGO:00335001280.018
positive regulation of response to woundingGO:1903036660.018
reactive oxygen species metabolic processGO:0072593840.018
lung developmentGO:00303241640.018
monosaccharide metabolic processGO:00059961060.018
spermatogenesisGO:00072832840.018
peptidyl amino acid modificationGO:00181933360.018
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.018
cellular protein complex assemblyGO:00436231160.017
immune effector processGO:00022523210.017
respiratory system developmentGO:00605411900.017
regulation of inflammatory responseGO:00507271470.017
anion transportGO:00068201770.017
anatomical structure homeostasisGO:00602491450.017
cellular response to extracellular stimulusGO:0031668810.017
engulfment of apoptotic cellGO:004365230.017
mapk cascadeGO:00001652810.017
negative regulation of actin filament depolymerizationGO:003083590.017
regulation of protein stabilityGO:0031647520.017
adult locomotory behaviorGO:0008344910.017
macromolecule catabolic processGO:00090572810.017
metanephric glomerular epithelial cell differentiationGO:007231220.017
sequestering of metal ionGO:0051238190.017
negative regulation of smooth muscle cell migrationGO:001491220.017
lymphocyte homeostasisGO:0002260640.017
regulation of cell projection organizationGO:00313442060.017
lymphocyte mediated immunityGO:00024491390.017
regulation of angiotensin metabolic processGO:006017740.017
alcohol metabolic processGO:00060661160.017
skeletal muscle organ developmentGO:00605381630.017
negative regulation of protein depolymerizationGO:1901880210.016
regulation of cell adhesionGO:00301551540.016
establishment of protein localization to vacuoleGO:007266640.016
transmembrane transportGO:00550854120.016
regulation of cellular amine metabolic processGO:0033238200.016
cell cycle g1 s phase transitionGO:0044843570.016
regulation of cellular response to growth factor stimulusGO:0090287820.016
actin filament polymerizationGO:0030041440.016
regulation of neuron projection developmentGO:00109751690.016
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.015
axon ensheathmentGO:0008366760.015
organic hydroxy compound metabolic processGO:19016152030.015
negative regulation of blood pressureGO:0045776220.015
cellular modified amino acid metabolic processGO:0006575630.015
positive regulation of leukocyte mediated cytotoxicityGO:0001912310.015
posttranscriptional regulation of gene expressionGO:00106081550.015
purine nucleoside triphosphate metabolic processGO:00091442260.015
protein import into nucleusGO:0006606950.015
negative regulation of neuron deathGO:1901215980.015
Human
multicellular organismal catabolic processGO:004424370.015
protein localization to vacuoleGO:007266540.015
small gtpase mediated signal transductionGO:0007264970.015
muscle contractionGO:00069361010.015
retrograde transport endosome to golgiGO:004214720.015
glucose homeostasisGO:00425931280.015
regulation of cellular ketone metabolic processGO:0010565660.015
vascular process in circulatory systemGO:0003018620.015
branching morphogenesis of an epithelial tubeGO:00487541590.015
mesonephros developmentGO:0001823970.015
negative regulation of platelet derived growth factor receptor alpha signaling pathwayGO:200058420.015
metanephric glomerular epithelial cell developmentGO:007231320.015
ossificationGO:00015032160.015
divalent metal ion transportGO:00708381720.015
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.015
positive regulation of hydrolase activityGO:00513451480.014
myotube cell developmentGO:0014904600.014
purine ribonucleoside triphosphate catabolic processGO:00092071990.014
regulation of arp2 3 complex mediated actin nucleationGO:003431510.014
sterol metabolic processGO:0016125580.014
positive regulation of nervous system developmentGO:00519622210.014
positive regulation of behaviorGO:0048520400.014
establishment of vesicle localizationGO:0051650810.014
phospholipid metabolic processGO:0006644870.014
positive regulation of fibronectin dependent thymocyte migrationGO:200041510.014
regulation of t cell activationGO:00508631700.014
nucleoside phosphate metabolic processGO:00067533380.014
positive regulation of reactive oxygen species biosynthetic processGO:190342820.014
negative regulation of kinase activityGO:0033673810.014
regulation of systemic arterial blood pressure by carotid body chemoreceptor signalingGO:000302710.014
nitrogen compound transportGO:00717052710.014
lipid transportGO:0006869980.014
leukocyte differentiationGO:00025213420.014
negative regulation of proteolysisGO:0045861740.014
regulation of protein serine threonine kinase activityGO:00719001570.014
thymocyte migrationGO:007267920.014
establishment of tissue polarityGO:0007164280.014
positive regulation of chemotaxisGO:0050921380.014
receptor mediated endocytosisGO:0006898510.014
protein targeting to vacuoleGO:000662330.014
cellular response to oxidative stressGO:0034599760.014
cellular homeostasisGO:00197252400.013
innate immune responseGO:00450871570.013
intracellular protein transportGO:00068862040.013
cytokine productionGO:00018163190.013
organic acid biosynthetic processGO:0016053860.013
cation transportGO:00068123990.013
fatty acid metabolic processGO:00066311210.013
wnt signaling pathwayGO:00160551880.013
regulation of secretionGO:00510462740.013
regulation of cellular amino acid metabolic processGO:000652150.013
cellular amino acid catabolic processGO:0009063250.013
circulatory system processGO:00030131970.013
wound healingGO:00420601570.013
Zebrafish
regulation of reactive oxygen species biosynthetic processGO:190342620.013
regulation of cytokine productionGO:00018172660.013
pigmentationGO:0043473710.013
neuromuscular process controlling balanceGO:0050885590.013
regulation of kinase activityGO:00435492490.013
regulation of monocyte chemotaxisGO:009002530.013
positive regulation of reactive oxygen species metabolic processGO:2000379110.013
cellular response to growth factor stimulusGO:00713631970.013
neutrophil migrationGO:1990266370.013
positive regulation of dna templated transcription elongationGO:003278620.013
glycosaminoglycan metabolic processGO:0030203340.013
gonad developmentGO:00084061410.013
response to oxidative stressGO:00069791230.012
purine nucleoside metabolic processGO:00422782410.012
hair cycleGO:0042633900.012
reactive nitrogen species metabolic processGO:200105700.012
regulation of homeostatic processGO:00328441820.012
blood circulationGO:00080151950.012
positive regulation of transferase activityGO:00513471670.012
aromatic compound catabolic processGO:00194392860.012
response to molecule of bacterial originGO:00022371430.012
hindbrain morphogenesisGO:0021575460.012
glucosamine containing compound metabolic processGO:190107130.012
positive regulation of eosinophil migrationGO:200041820.012
regulation of actin nucleationGO:005112540.012
nucleobase containing small molecule metabolic processGO:00550863520.012
regulation of protein depolymerizationGO:1901879260.012
positive regulation of glutamate secretionGO:001404920.012
multi organism reproductive behaviorGO:0044705290.012
metanephric mesenchymal cell migrationGO:003578920.012
heterocycle catabolic processGO:00467002800.012
purine nucleotide metabolic processGO:00061633020.012
cellular response to organonitrogen compoundGO:00714171450.012
cellular ion homeostasisGO:00068731650.012
telencephalon cell migrationGO:0022029550.012
eosinophil migrationGO:007267730.012
glycerolipid metabolic processGO:00464861220.012
response to lipopolysaccharideGO:00324961280.012
developmental growth involved in morphogenesisGO:00605601380.012
regulation of endopeptidase activityGO:0052548890.012
cellular response to monosaccharide stimulusGO:0071326470.012
myeloid leukocyte migrationGO:0097529570.012
regulation of plasma lipoprotein particle levelsGO:0097006230.012
urogenital system developmentGO:00016552610.011
cation transmembrane transportGO:00986552660.011
regulation of cellular component biogenesisGO:00440871810.011
regulation of actin filament based processGO:0032970990.011
regulation of reactive oxygen species metabolic processGO:2000377400.011
positive regulation of protein kinase b signalingGO:0051897320.011
regulation of cytoplasmic transportGO:19036491120.011
extracellular matrix dependent thymocyte migrationGO:007268010.011
leukocyte apoptotic processGO:0071887710.011
regulation of neuron apoptotic processGO:00435231220.011
Human
protein depolymerizationGO:0051261340.011
regulation of body fluid levelsGO:00508781620.011
regulation of tube sizeGO:0035150570.011
peripheral nervous system developmentGO:0007422530.011
single fertilizationGO:0007338820.011
rhythmic processGO:00485111740.011
negative regulation of cell projection organizationGO:0031345560.011
nucleoside catabolic processGO:00091642060.011
carbohydrate biosynthetic processGO:0016051740.011
neuron projection extensionGO:1990138640.011
nerve developmentGO:0021675670.011
cell growthGO:00160491300.011
rho protein signal transductionGO:0007266320.011
negative regulation of cellular component organizationGO:00511291940.011
purine ribonucleoside metabolic processGO:00461282410.011
lipoprotein metabolic processGO:0042157430.011
purine nucleoside catabolic processGO:00061522050.011
positive regulation of t cell proliferationGO:0042102520.011
regulation of lipid metabolic processGO:00192161180.011
cellular response to molecule of bacterial originGO:0071219830.011
keratinocyte proliferationGO:0043616210.011
multicellular organism growthGO:00352641610.011
fatty acid biosynthetic processGO:0006633410.011
negative regulation of cytoskeleton organizationGO:0051494360.011
mesenchyme developmentGO:00604851520.011
positive regulation of map kinase activityGO:0043406840.011
metal ion homeostasisGO:00550651890.011
cation homeostasisGO:00550802120.011
phospholipid transfer to membraneGO:000664920.011
positive regulation of vasodilationGO:004590930.011
gland developmentGO:00487323300.010
response to growth factorGO:00708481980.010
regulation of cell shapeGO:0008360390.010
lipid modificationGO:0030258650.010
amino acid transportGO:0006865610.010
negative regulation of molecular functionGO:00440922580.010
positive regulation of secretion by cellGO:19035321140.010
antigen processing and presentationGO:0019882470.010
negative regulation of hypersensitivityGO:000288430.010
positive regulation of exocytosisGO:0045921200.010
vasodilationGO:0042311280.010
diol metabolic processGO:003431150.010
negative regulation of cell proliferationGO:00082852960.010
response to tumor necrosis factorGO:0034612260.010
germ cell developmentGO:00072811850.010
regulation of cellular component sizeGO:00325351210.010
lymphocyte activation involved in immune responseGO:0002285930.010
neuromuscular processGO:0050905990.010
acetylcholine transportGO:001587020.010
alpha beta t cell activationGO:0046631910.010
regulation of systemic arterial blood pressureGO:0003073610.010

Lgmn disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
inherited metabolic disorderDOID:65500.891
disease of metabolismDOID:001466700.891
lysosomal storage diseaseDOID:321100.827
lipid storage diseaseDOID:945500.827
nervous system diseaseDOID:86300.574
disease of anatomical entityDOID:700.574
sphingolipidosisDOID:192700.355
central nervous system diseaseDOID:33100.239
cerebral degenerationDOID:144300.179
brain diseaseDOID:93600.179
connective tissue diseaseDOID:6500.039
musculoskeletal system diseaseDOID:1700.039
lymphatic system diseaseDOID:7500.035
immune system diseaseDOID:291400.035
neuropathyDOID:87000.027
neuromuscular diseaseDOID:44000.027
charcot marie tooth diseaseDOID:1059500.027
neuronal ceroid lipofuscinosisDOID:1450300.022
disease of mental healthDOID:15000.020
neurodegenerative diseaseDOID:128900.018
eye diseaseDOID:561400.015
retinal diseaseDOID:567900.015
sensory system diseaseDOID:005015500.015
eye and adnexa diseaseDOID:149200.015
electroclinical syndromeDOID:005070100.010
epilepsy syndromeDOID:182600.010