Mus musculus

118 known processes

Slc11a2

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

(Aliases: DMT1,Nramp2,van,mk,DCT1)

Slc11a2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cofactor metabolic processGO:0051186800.926
erythrocyte differentiationGO:0030218880.879
transition metal ion transportGO:0000041380.797
homeostasis of number of cellsGO:00488722100.778
cation homeostasisGO:00550802120.728
folic acid containing compound metabolic processGO:000676030.694
transition metal ion homeostasisGO:0055076540.685
myeloid cell differentiationGO:00300992330.504
metal ion homeostasisGO:00550651890.502
iron ion homeostasisGO:0055072360.438
cellular ion homeostasisGO:00068731650.433
Mouse
cellular amino acid metabolic processGO:00065201030.404
myeloid cell homeostasisGO:00022621140.373
inorganic ion transmembrane transportGO:00986602340.357
tetrapyrrole biosynthetic processGO:0033014160.344
cofactor biosynthetic processGO:0051188410.295
porphyrin containing compound metabolic processGO:0006778220.258
tetrapyrrole metabolic processGO:0033013220.254
cellular transition metal ion homeostasisGO:0046916320.219
Mouse
regulation of translational initiation in response to stressGO:004355850.209
porphyrin containing compound biosynthetic processGO:0006779160.204
cellular metal ion homeostasisGO:00068751510.198
Mouse
cation transportGO:00068123990.197
myeloid leukocyte differentiationGO:00025731190.182
pteridine containing compound metabolic processGO:004255850.179
cellular iron ion homeostasisGO:0006879160.177
Mouse
glutathione metabolic processGO:0006749160.150
embryonic hemopoiesisGO:0035162230.150
protein localization to plasma membraneGO:0072659570.144
response to iron ionGO:001003940.143
Human
transmembrane transportGO:00550854120.141
cellular homeostasisGO:00197252400.137
Mouse
oxidation reduction processGO:00551143420.133
lymphocyte proliferationGO:00466511640.129
Mouse
iron ion transportGO:0006826170.128
response to starvationGO:0042594650.126
erythrocyte maturationGO:004324960.114
regulation of reactive oxygen species biosynthetic processGO:190342620.113
amine metabolic processGO:0009308450.104
organonitrogen compound biosynthetic processGO:19015661920.097
regulation of cellular ketone metabolic processGO:0010565660.095
regulation of transcription from rna polymerase ii promoter in response to ironGO:003439530.087
positive regulation of potassium ion transmembrane transporter activityGO:190101810.084
regulation of cellular amino acid metabolic processGO:000652150.083
protein localization to membraneGO:00726571080.082
cellular modified amino acid metabolic processGO:0006575630.081
membrane organizationGO:00610242450.078
multicellular organism growthGO:00352641610.078
cellular ketone metabolic processGO:0042180840.075
t cell activationGO:00421102890.074
Mouse
response to extracellular stimulusGO:00099911270.074
fertilizationGO:00095661270.073
ion transmembrane transportGO:00342203610.072
t cell proliferationGO:00420981200.069
Mouse
circulatory system processGO:00030131970.067
lipid homeostasisGO:0055088630.067
polysaccharide metabolic processGO:0005976390.067
alpha amino acid metabolic processGO:1901605590.066
copper ion transportGO:0006825100.065
Human
carbohydrate transportGO:0008643620.063
trivalent inorganic cation transportGO:007251250.063
endomembrane system organizationGO:00102561470.061
cell maturationGO:00484691270.061
immune effector processGO:00022523210.060
Mouse
wound healingGO:00420601570.060
Mouse
cellular response to nutrient levelsGO:0031669640.058
protein localization to organelleGO:00333651850.058
Mouse
leukocyte differentiationGO:00025213420.058
coenzyme metabolic processGO:0006732520.057
osteoclast differentiationGO:0030316620.056
hindbrain developmentGO:00309021280.055
reactive oxygen species biosynthetic processGO:190340980.055
positive regulation of reactive oxygen species metabolic processGO:2000379110.055
axon guidanceGO:00074111410.053
protein targeting to membraneGO:0006612200.053
body morphogenesisGO:0010171450.052
cerebellar purkinje cell layer developmentGO:0021680260.051
multicellular organismal homeostasisGO:00488711640.051
nitrogen compound transportGO:00717052710.050
Mouse
multicellular organismal signalingGO:0035637910.049
cell activation involved in immune responseGO:00022631260.047
Mouse
calcium ion transport from endoplasmic reticulum to cytosolGO:1903514120.047
small gtpase mediated signal transductionGO:0007264970.047
positive regulation of cellular amino acid metabolic processGO:004576430.045
regulation of tissue remodelingGO:0034103380.045
regulation of intracellular phGO:0051453110.044
Mouse
neuron projection guidanceGO:00974851410.044
release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:0014808120.043
negative regulation of heart rateGO:001045940.043
positive regulation of natural killer cell mediated immunityGO:0002717160.043
hemoglobin metabolic processGO:0020027130.042
regulation of protein bindingGO:0043393600.042
sensory perceptionGO:00076002450.042
transmission of nerve impulseGO:0019226760.041
lymphocyte homeostasisGO:0002260640.041
peptidyl amino acid modificationGO:00181933360.041
positive regulation of bone resorptionGO:0045780130.040
cellular chemical homeostasisGO:00550822150.040
Mouse
male gamete generationGO:00482322850.039
cellular response to dna damage stimulusGO:00069742070.039
trabecula formationGO:0060343240.039
cellular carbohydrate metabolic processGO:00442621190.038
sensory perception of mechanical stimulusGO:00509541070.038
regulation of lymphocyte activationGO:00512492400.037
cellular amine metabolic processGO:0044106440.037
bone remodelingGO:0046849530.037
heart processGO:0003015940.037
spermatogenesisGO:00072832840.037
monosaccharide metabolic processGO:00059961060.036
developmental maturationGO:00217001930.036
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.036
action potentialGO:0001508780.036
reactive nitrogen species metabolic processGO:200105700.035
urogenital system developmentGO:00016552610.035
trabecula morphogenesisGO:0061383400.034
t cell mediated immunityGO:0002456500.034
Mouse
fibrinolysisGO:004273030.034
axon ensheathmentGO:0008366760.034
tissue remodelingGO:00487711020.034
protein localization to juxtaparanode region of axonGO:007120540.033
response to light stimulusGO:00094161350.033
positive regulation of reactive oxygen species biosynthetic processGO:190342820.033
regulation of carbohydrate biosynthetic processGO:0043255400.033
peroxisome organizationGO:000703170.033
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.033
Mouse
positive regulation of potassium ion transportGO:004326830.033
inflammatory responseGO:00069542440.032
Mouse
sequestering of metal ionGO:0051238190.032
positive regulation of bone remodelingGO:0046852130.032
regulation of cellular amine metabolic processGO:0033238200.032
cellular response to lipopolysaccharideGO:0071222770.032
leukocyte activation involved in immune responseGO:00023661260.031
Mouse
cellular polysaccharide metabolic processGO:0044264380.031
regulation of ion transportGO:00432692150.031
regulation of response to dna damage stimulusGO:2001020340.030
sterol homeostasisGO:0055092450.030
regulation of sodium ion transportGO:0002028290.030
protein heterooligomerizationGO:0051291140.030
chemotaxisGO:00069352470.029
establishment of glial blood brain barrierGO:006085720.029
nucleocytoplasmic transportGO:00069131390.029
Mouse
tissue homeostasisGO:00018941150.028
anatomical structure homeostasisGO:00602491450.028
positive regulation of homeostatic processGO:0032846640.028
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.028
sa node cell to atrial cardiac muscle cell signallingGO:008601840.028
regulation of cytokine productionGO:00018172660.026
Mouse
translationGO:0006412930.026
glucose 6 phosphate metabolic processGO:005115680.026
adaptive immune responseGO:00022501550.026
Mouse
multicellular organismal iron ion homeostasisGO:006058680.025
regulation of homeostatic processGO:00328441820.025
common partner smad protein phosphorylationGO:000718220.025
cellular lipid metabolic processGO:00442553230.025
cellular divalent inorganic cation homeostasisGO:00725031270.025
nuclear divisionGO:00002801580.025
primary neural tube formationGO:0014020950.024
plasma membrane organizationGO:0007009900.024
posttranscriptional regulation of gene expressionGO:00106081550.024
Mouse
cellular response to extracellular stimulusGO:0031668810.024
regulation of reactive oxygen species metabolic processGO:2000377400.024
cellular response to erythropoietinGO:003601810.024
regulation of leukocyte mediated immunityGO:00027031040.023
dephosphorylationGO:00163111290.023
bone resorptionGO:0045453380.023
protein importGO:00170381010.023
Mouse
cellular amide metabolic processGO:0043603580.023
bmp signaling pathwayGO:0030509930.023
digestive tract developmentGO:00485651900.022
axonogenesisGO:00074092740.022
cytokine mediated signaling pathwayGO:00192211150.022
regulation of membrane potentialGO:00423911920.022
alcohol metabolic processGO:00060661160.022
negative regulation of cellular amino acid metabolic processGO:004576300.022
intrinsic apoptotic signaling pathwayGO:00971931320.021
reactive oxygen species metabolic processGO:0072593840.021
heart contractionGO:0060047930.021
iron ion import into cellGO:009745940.021
spleen developmentGO:0048536390.020
translational initiationGO:0006413240.020
neural tube closureGO:0001843900.020
cholesterol homeostasisGO:0042632440.020
leukocyte proliferationGO:00706611720.020
Mouse
regulation of hormone levelsGO:00108172110.020
ras protein signal transductionGO:0007265770.020
coagulationGO:0050817780.020
regulation of cell activationGO:00508652890.020
hemostasisGO:0007599780.020
regulation of bmp signaling pathwayGO:0030510600.020
positive regulation of immune effector processGO:00026991070.020
cell fate commitmentGO:00451652100.020
visual perceptionGO:0007601520.020
erythropoietin mediated signaling pathwayGO:003816210.019
photoreceptor cell differentiationGO:0046530520.019
cation transmembrane transportGO:00986552660.019
positive regulation of cellular amine metabolic processGO:003324050.019
production of molecular mediator of immune responseGO:00024401030.019
Mouse
regulation of cellular response to stressGO:00801351590.019
b cell differentiationGO:0030183780.019
regulation of t cell activationGO:00508631700.019
hormone metabolic processGO:0042445860.019
eye photoreceptor cell differentiationGO:0001754410.019
cell cell junction assemblyGO:0007043270.019
glucan metabolic processGO:0044042320.018
positive regulation of potassium ion transmembrane transportGO:190138130.018
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101610.018
amino acid transportGO:0006865610.018
Mouse
sensory perception of soundGO:0007605970.018
regulation of protein stabilityGO:0031647520.018
cellular response to inorganic substanceGO:0071241370.018
regulation of leukocyte differentiationGO:19021051590.017
cellular component assembly involved in morphogenesisGO:00109271390.017
response to erythropoietinGO:003601710.017
actin mediated cell contractionGO:0070252150.017
establishment of protein localization to plasma membraneGO:0090002340.017
glucose transportGO:0015758560.017
positive regulation of intrinsic apoptotic signaling pathwayGO:2001244250.017
regulation of metal ion transportGO:00109591060.017
divalent inorganic cation transportGO:00725111780.017
nuclear transportGO:00511691390.017
Mouse
metencephalon developmentGO:0022037890.016
tube formationGO:00351481400.016
lipid storageGO:0019915360.016
release of sequestered calcium ion into cytosolGO:0051209420.016
positive regulation of insulin secretionGO:0032024260.016
sodium ion transportGO:0006814730.016
positive regulation of calcium ion transportGO:0051928270.016
protein modification by small protein conjugation or removalGO:00706472070.016
positive regulation of leukocyte proliferationGO:0070665730.016
positive regulation of cell killingGO:0031343330.015
protein localization to nucleusGO:00345041210.015
Mouse
apoptotic signaling pathwayGO:00971903060.015
calcium ion transportGO:00068161590.015
hexose transportGO:0008645560.015
platelet derived growth factor receptor alpha signaling pathwayGO:003579030.015
regulation of vesicle mediated transportGO:00606271390.015
Mouse
iron ion importGO:009728650.015
zymogen activationGO:0031638410.015
Human
cellular response to thyroid hormone stimulusGO:009706710.015
cell cell junction organizationGO:0045216720.015
compound eye developmentGO:004874910.015
positive regulation of protein bindingGO:0032092290.015
regulation of bone remodelingGO:0046850280.015
regulation of cell killingGO:0031341400.015
organic anion transportGO:00157111370.015
Mouse
protein modification by small protein conjugationGO:00324461870.014
epithelial cell developmentGO:00020641590.014
gland developmentGO:00487323300.014
learning or memoryGO:00076111480.014
cytosolic calcium ion homeostasisGO:0051480700.014
regulation of wnt signaling pathwayGO:00301111230.014
mitotic cell cycle processGO:19030471590.014
regulation of myeloid cell differentiationGO:0045637960.014
positive regulation of cell activationGO:00508671580.014
rho protein signal transductionGO:0007266320.014
response to copper ionGO:004668830.014
central nervous system neuron differentiationGO:00219531620.014
response to radiationGO:00093141650.014
cytoplasmic transportGO:00164822340.014
Mouse
hexose metabolic processGO:0019318980.014
sequestering of calcium ionGO:0051208180.014
divalent inorganic cation homeostasisGO:00725071380.014
sulfur compound metabolic processGO:00067901000.014
hydrogen ion transmembrane transportGO:1902600250.014
regulation of peptide transportGO:0090087910.014
protein targetingGO:00066051430.014
Mouse
respiratory system developmentGO:00605411900.013
cytokine productionGO:00018163190.013
Mouse
regulation of lymphocyte mediated immunityGO:0002706840.013
intracellular protein transportGO:00068862040.013
Mouse
digestive system developmentGO:00551232000.013
neural tube formationGO:00018411080.013
glucan biosynthetic processGO:0009250140.013
neuronal action potentialGO:0019228540.013
regulation of phGO:0006885260.013
Mouse
cellular response to external stimulusGO:0071496880.013
organic acid transportGO:00158491010.013
Mouse
establishment or maintenance of cytoskeleton polarityGO:003095220.013
potassium ion transmembrane transportGO:0071805430.013
oxidoreduction coenzyme metabolic processGO:0006733160.013
nuclear importGO:0051170950.013
Mouse
regulation of t cell mediated immunityGO:0002709340.013
embryonic epithelial tube formationGO:00018381300.013
lymphocyte differentiationGO:00300982420.013
regulation of transmembrane transportGO:00347621280.013
regulation of cardiac muscle cell membrane potentialGO:008603630.013
lung developmentGO:00303241640.013
response to nutrient levelsGO:00316671090.013
positive regulation of defense responseGO:00313491240.013
regulation of antimicrobial humoral responseGO:000275930.013
blood circulationGO:00080151950.013
antigen processing and presentation of exogenous antigenGO:0019884260.013
cellular polysaccharide biosynthetic processGO:0033692190.013
endothelium developmentGO:0003158450.012
lymphocyte activation involved in immune responseGO:0002285930.012
Mouse
vitamin transmembrane transportGO:003546140.012
striated muscle adaptationGO:0014888260.012
nucleoside triphosphate catabolic processGO:00091432050.012
response to molecule of bacterial originGO:00022371430.012
Mouse
purine containing compound metabolic processGO:00725213110.012
regulation of defense responseGO:00313472330.012
myelinationGO:0042552740.012
cellular response to granulocyte macrophage colony stimulating factor stimulusGO:009701130.012
positive regulation of hormone secretionGO:0046887380.012
organic hydroxy compound metabolic processGO:19016152030.012
cell adhesionGO:00071553290.012
positive regulation of lymphocyte activationGO:00512511400.012
glucose metabolic processGO:0006006920.012
progesterone metabolic processGO:004244840.012
positive regulation of growthGO:00459271040.012
metanephric glomerular mesangium developmentGO:007222330.012
cellular response to starvationGO:0009267570.012
divalent metal ion transportGO:00708381720.012
hormone secretionGO:00468791280.012
leukocyte mediated cytotoxicityGO:0001909620.012
hemoglobin biosynthetic processGO:004254170.012
regulation of bone resorptionGO:0045124240.012
macromolecule catabolic processGO:00090572810.012
stem cell differentiationGO:00488632680.012
regulation of translational initiationGO:0006446150.012
negative regulation of cellular amine metabolic processGO:003323910.012
cellular response to biotic stimulusGO:0071216920.012
lymphocyte mediated immunityGO:00024491390.012
Mouse
regulation of cell cycleGO:00517262810.012
response to glycosideGO:190341620.011
endocytosisGO:00068971680.011
Mouse
retina morphogenesis in camera type eyeGO:0060042450.011
positive regulation of cell cycleGO:0045787920.011
glycerolipid metabolic processGO:00464861220.011
oocyte axis specificationGO:000730920.011
protein processingGO:00164851630.011
Human
response to interleukin 15GO:007067230.011
cellular protein complex assemblyGO:00436231160.011
myosin filament organizationGO:003103330.011
regulation of peptide hormone secretionGO:0090276750.011
carbohydrate biosynthetic processGO:0016051740.011
cellular response to lipidGO:00713961450.011
organophosphate catabolic processGO:00464342320.011
potassium ion transportGO:0006813520.011
regulation of bindingGO:00510981110.011
inorganic cation import into cellGO:009865940.011
monosaccharide biosynthetic processGO:0046364440.011
regulation of apoptotic signaling pathwayGO:20012331970.011
mitotic cell cycleGO:00002781950.011
anion transmembrane transportGO:0098656710.011
positive regulation of t cell activationGO:00508701010.011
central nervous system neuron developmentGO:0021954670.011
regulation of innate immune responseGO:0045088910.011
mitotic nuclear divisionGO:0007067480.011
membrane lipid metabolic processGO:0006643530.011
exocytosisGO:00068871210.011
peptide hormone secretionGO:00300721090.011
cellular response to x rayGO:007148120.011
protein catabolic processGO:00301632210.011
kit signaling pathwayGO:003810930.011
regulation of heart contractionGO:0008016770.011
metanephric glomerular capillary formationGO:007227730.011
regulation of b cell differentiationGO:0045577230.011
cellularizationGO:000734910.011
erk1 and erk2 cascadeGO:0070371770.011
regulation of cell shapeGO:0008360390.011
monosaccharide transportGO:0015749580.010
synapse organizationGO:00508081250.010
gastrulationGO:00073691160.010
regulation of t cell differentiationGO:0045580830.010
leukocyte mediated immunityGO:00024431740.010
Mouse
apical constrictionGO:000338340.010
polysaccharide biosynthetic processGO:0000271200.010
pyridine containing compound metabolic processGO:0072524140.010
oocyte constructionGO:000730820.010
membrane lipid biosynthetic processGO:0046467320.010
regulation of synaptic growth at neuromuscular junctionGO:000858240.010
purine nucleotide catabolic processGO:00061952110.010
natural killer cell mediated cytotoxicityGO:0042267290.010
insulin secretionGO:0030073890.010
nucleotide metabolic processGO:00091173320.010
regulation of secretionGO:00510462740.010
muscle cell differentiationGO:00426922610.010
extracellular matrix organizationGO:00301981470.010
hematopoietic progenitor cell differentiationGO:00022441430.010
striated muscle myosin thick filament assemblyGO:007168810.010

Slc11a2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
hematopoietic system diseaseDOID:7400.765
Human
anemiaDOID:235500.765
Human
disease of anatomical entityDOID:700.765
Human
immune system diseaseDOID:291400.765
Human
metal metabolism disorderDOID:89600.146
disease of metabolismDOID:001466700.146
inherited metabolic disorderDOID:65500.146
normocytic anemiaDOID:72000.122
hemolytic anemiaDOID:58300.122
nervous system diseaseDOID:86300.027
central nervous system diseaseDOID:33100.024
organ system cancerDOID:005068600.017
immune system cancerDOID:006008300.017
disease of cellular proliferationDOID:1456600.017
cancerDOID:16200.017
hematologic cancerDOID:253100.012