IMP: Integrative Multi-species Prediction

Mus musculus

119 known processes

Shc1

src homology 2 domain-containing transforming protein C1

(Aliases: p66shc,Shc,ShcA,p66)

Ensembl: ENSMUSG00000042626
Entrez: 20416
UniProtKB: P98083

Process Predictions
Disease Predictions

Shc1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of mapk cascade	GO:0043408	248	0.995
platelet derived growth factor receptor signaling pathway	GO:0048008	32	0.993
ras protein signal transduction	GO:0007265	77	0.992
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.986
fibroblast growth factor receptor signaling pathway	GO:0008543	46	0.951
negative regulation of cellular amine metabolic process	GO:0033239	1	0.947
response to oxidative stress	GO:0006979	123	0.947	Rat
leukocyte differentiation	GO:0002521	342	0.944
positive regulation of kinase activity	GO:0033674	155	0.906
myeloid cell differentiation	GO:0030099	233	0.901
negative regulation of peptidyl tyrosine phosphorylation	GO:0050732	17	0.892
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.879
epidermal growth factor receptor signaling pathway	GO:0007173	28	0.873
cellular response to fibroblast growth factor stimulus	GO:0044344	47	0.850
rho protein signal transduction	GO:0007266	32	0.832
regulation of ras gtpase activity	GO:0032318	88	0.827
endocytosis	GO:0006897	168	0.824
positive regulation of mapk cascade	GO:0043410	170	0.819
cytoplasmic transport	GO:0016482	234	0.816
actin cytoskeleton organization	GO:0030036	220	0.798
myeloid leukocyte differentiation	GO:0002573	119	0.780
negative regulation of granulocyte differentiation	GO:0030853	3	0.780
regulation of mast cell activation	GO:0033003	21	0.770
negative regulation of phosphorylation	GO:0042326	166	0.769
regulation of b cell differentiation	GO:0045577	23	0.766
amine metabolic process	GO:0009308	45	0.759
regulation of rho gtpase activity	GO:0032319	58	0.758
small gtpase mediated signal transduction	GO:0007264	97	0.757
negative regulation of receptor activity	GO:2000272	5	0.721
regulation of transferase activity	GO:0051338	263	0.720
regulation of ras protein signal transduction	GO:0046578	114	0.717
regulation of map kinase activity	GO:0043405	120	0.714
positive regulation of intracellular transport	GO:0032388	70	0.701
alcohol catabolic process	GO:0046164	16	0.700
regulation of antigen receptor mediated signaling pathway	GO:0050854	29	0.692
positive regulation of rac gtpase activity	GO:0032855	14	0.683
negative regulation of cell activation	GO:0050866	111	0.681
osteoclast differentiation	GO:0030316	62	0.678
regulation of vesicle mediated transport	GO:0060627	139	0.674
positive regulation of rho gtpase activity	GO:0032321	41	0.670
regulation of lymphocyte differentiation	GO:0045619	107	0.666
lysosome localization	GO:0032418	20	0.652
developmental growth involved in morphogenesis	GO:0060560	138	0.646
phosphatidylinositol metabolic process	GO:0046488	45	0.643
response to fibroblast growth factor	GO:0071774	47	0.637
regulation of anatomical structure size	GO:0090066	178	0.631	Rat
negative regulation of phosphorus metabolic process	GO:0010563	184	0.625
positive regulation of leukocyte mediated immunity	GO:0002705	70	0.623
regulation of kinase activity	GO:0043549	249	0.617
mitochondrion distribution	GO:0048311	4	0.616
response to organonitrogen compound	GO:0010243	246	0.616	Rat
negative regulation of protein tyrosine kinase activity	GO:0061099	3	0.614
regulation of cellular response to stress	GO:0080135	159	0.604
lipid storage	GO:0019915	36	0.601
response to growth factor	GO:0070848	198	0.600
synaptic vesicle recycling	GO:0036465	19	0.589
erbb signaling pathway	GO:0038127	32	0.573
negative regulation of epidermal growth factor activated receptor activity	GO:0007175	3	0.556
regulation of protein kinase activity	GO:0045859	232	0.554
guanosine containing compound metabolic process	GO:1901068	144	0.537
regulation of mast cell activation involved in immune response	GO:0033006	17	0.526
mapk cascade	GO:0000165	281	0.525
regulation of epidermal growth factor activated receptor activity	GO:0007176	7	0.523
gland development	GO:0048732	330	0.517
muscle cell differentiation	GO:0042692	261	0.515
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO:1902043	13	0.504
regulation of intracellular transport	GO:0032386	159	0.500
regeneration	GO:0031099	38	0.499	Rat
glycerophospholipid metabolic process	GO:0006650	71	0.496
labyrinthine layer development	GO:0060711	49	0.493
positive regulation of leukocyte differentiation	GO:1902107	86	0.484
peptidyl serine modification	GO:0018209	83	0.478
negative regulation of protein phosphorylation	GO:0001933	126	0.476
lens development in camera type eye	GO:0002088	62	0.476
urogenital system development	GO:0001655	261	0.470
cellular response to peptide	GO:1901653	92	0.467	Rat
cellular response to growth factor stimulus	GO:0071363	197	0.459
regulation of t cell activation	GO:0050863	170	0.451
response to peptide hormone	GO:0043434	127	0.444	Rat
dephosphorylation	GO:0016311	129	0.438
organophosphate catabolic process	GO:0046434	232	0.433
organic hydroxy compound catabolic process	GO:1901616	25	0.412
regulation of cell activation	GO:0050865	289	0.406
leukocyte proliferation	GO:0070661	172	0.405
negative regulation of map kinase activity	GO:0043407	34	0.404
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.398
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.391
b cell differentiation	GO:0030183	78	0.389
phospholipid dephosphorylation	GO:0046839	6	0.387
cell cycle g1 s phase transition	GO:0044843	57	0.381
regulation of proteolysis	GO:0030162	164	0.381
regulation of leukocyte mediated immunity	GO:0002703	104	0.378
peptidyl threonine phosphorylation	GO:0018107	31	0.373
intracellular distribution of mitochondria	GO:0048312	1	0.371
ribonucleotide metabolic process	GO:0009259	291	0.369
positive regulation of protein modification process	GO:0031401	299	0.368
homeostasis of number of cells	GO:0048872	210	0.367
terminal button organization	GO:0072553	3	0.362
t cell receptor signaling pathway	GO:0050852	46	0.360
germ cell development	GO:0007281	185	0.357
organelle localization	GO:0051640	179	0.357
regulation of lymphocyte proliferation	GO:0050670	117	0.357
activation of rac gtpase activity	GO:0032863	2	0.350
negative regulation of phosphate metabolic process	GO:0045936	184	0.349
positive regulation of apoptotic process	GO:0043065	217	0.349
organic cyclic compound catabolic process	GO:1901361	295	0.347
t cell proliferation	GO:0042098	120	0.346
inositol phosphate catabolic process	GO:0071545	4	0.344
organ regeneration	GO:0031100	2	0.342	Rat
synaptic transmission	GO:0007268	329	0.340	Mouse
small molecule catabolic process	GO:0044282	71	0.336
positive regulation of map kinase activity	GO:0043406	84	0.327
axonogenesis	GO:0007409	274	0.326
olfactory learning	GO:0008355	2	0.326
regulation of cellular amine metabolic process	GO:0033238	20	0.321
regulation of mitotic cell cycle	GO:0007346	126	0.321
regulation of cellular catabolic process	GO:0031329	242	0.320
protein localization to nucleus	GO:0034504	121	0.319
regulation of protein tyrosine kinase activity	GO:0061097	17	0.318
cytokine mediated signaling pathway	GO:0019221	115	0.315
cytokine production	GO:0001816	319	0.310
regionalization	GO:0003002	337	0.308
regulation of insulin receptor signaling pathway	GO:0046626	21	0.305
skeletal system morphogenesis	GO:0048705	203	0.305
t cell tolerance induction	GO:0002517	6	0.300
synaptic vesicle localization	GO:0097479	59	0.298
negative regulation of mapk cascade	GO:0043409	65	0.297
mitotic cell cycle	GO:0000278	195	0.296
regulation of actin cytoskeleton organization	GO:0032956	84	0.295
rac protein signal transduction	GO:0016601	13	0.293
cellular response to organonitrogen compound	GO:0071417	145	0.292	Rat
humoral immune response	GO:0006959	57	0.291
regulation of cell cycle	GO:0051726	281	0.291
positive regulation of protein catabolic process	GO:0045732	60	0.290
lymphocyte proliferation	GO:0046651	164	0.290
apoptotic signaling pathway	GO:0097190	306	0.287
negative regulation of erbb signaling pathway	GO:1901185	7	0.286
positive regulation of myeloid leukocyte mediated immunity	GO:0002888	14	0.284
photoreceptor cell differentiation	GO:0046530	52	0.283
ribonucleoside catabolic process	GO:0042454	206	0.281
erk1 and erk2 cascade	GO:0070371	77	0.280
calcium ion transport into cytosol	GO:0060402	48	0.276
neural precursor cell proliferation	GO:0061351	121	0.276
cell type specific apoptotic process	GO:0097285	268	0.275
nucleoside metabolic process	GO:0009116	246	0.275
blood vessel morphogenesis	GO:0048514	285	0.274
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	6	0.271
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.271
protein catabolic process	GO:0030163	221	0.271
positive regulation of gtpase activity	GO:0043547	85	0.268
immune effector process	GO:0002252	321	0.265	Fly
regulation of protein serine threonine kinase activity	GO:0071900	157	0.265
myotube differentiation	GO:0014902	105	0.264
positive regulation of protein phosphorylation	GO:0001934	242	0.254
response to peptide	GO:1901652	136	0.252	Rat
glycerolipid biosynthetic process	GO:0045017	50	0.252
monocyte differentiation	GO:0030224	9	0.252
cellular ketone metabolic process	GO:0042180	84	0.251
positive regulation of t cell tolerance induction	GO:0002666	6	0.251
synaptic vesicle transport	GO:0048489	57	0.248
fused antrum stage	GO:0048165	1	0.246
forebrain development	GO:0030900	302	0.244
positive regulation of cell death	GO:0010942	224	0.240
protein kinase b signaling	GO:0043491	74	0.239
embryonic placenta development	GO:0001892	98	0.239
negative regulation of cellular protein metabolic process	GO:0032269	247	0.238
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.235
regulation of rho protein signal transduction	GO:0035023	71	0.234
neuron projection extension	GO:1990138	64	0.234
nucleotide catabolic process	GO:0009166	217	0.233
peptidyl amino acid modification	GO:0018193	336	0.233
cell cell signaling involved in cell fate commitment	GO:0045168	35	0.231
intracellular protein transport	GO:0006886	204	0.231
myeloid leukocyte activation	GO:0002274	83	0.229
nucleotide metabolic process	GO:0009117	332	0.228
phosphorylated carbohydrate dephosphorylation	GO:0046838	4	0.228
positive regulation of transferase activity	GO:0051347	167	0.228
positive regulation of cell migration	GO:0030335	109	0.224
release of sequestered calcium ion into cytosol	GO:0051209	42	0.222
positive regulation of protein kinase b signaling	GO:0051897	32	0.221
neutrophil differentiation	GO:0030223	3	0.220
guanosine containing compound catabolic process	GO:1901069	144	0.219
activation of mapk activity	GO:0000187	59	0.218
regulation of lung blood pressure	GO:0014916	2	0.218
nucleoside catabolic process	GO:0009164	206	0.215
purine nucleotide catabolic process	GO:0006195	211	0.215
regulation of receptor activity	GO:0010469	41	0.213
regulation of ion transport	GO:0043269	215	0.211
macromolecule catabolic process	GO:0009057	281	0.210
establishment of organelle localization	GO:0051656	122	0.210
regulation of cell cycle process	GO:0010564	160	0.209
actin filament organization	GO:0007015	113	0.209
regulation of leukocyte differentiation	GO:1902105	159	0.208
lymphocyte differentiation	GO:0030098	242	0.206
t cell activation	GO:0042110	289	0.204
t cell anergy	GO:0002870	4	0.203
nucleoside phosphate metabolic process	GO:0006753	338	0.202
positive regulation of cytoplasmic transport	GO:1903651	40	0.200
positive regulation of tolerance induction	GO:0002645	8	0.197
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.197
digestive system development	GO:0055123	200	0.197
sensory organ morphogenesis	GO:0090596	242	0.196
insulin receptor signaling pathway	GO:0008286	49	0.191	Rat
regulation of jun kinase activity	GO:0043506	40	0.190
positive regulation of jun kinase activity	GO:0043507	30	0.190
regulation of homeostatic process	GO:0032844	182	0.190
regulation of organelle organization	GO:0033043	289	0.189
regulation of tolerance induction to self antigen	GO:0002649	1	0.188
negative regulation of immune system process	GO:0002683	209	0.187
regulation of cellular senescence	GO:2000772	6	0.186
skin development	GO:0043588	220	0.185
cellular amino acid metabolic process	GO:0006520	103	0.184
lateral inhibition	GO:0046331	1	0.184
protein targeting	GO:0006605	143	0.181
positive regulation of ras gtpase activity	GO:0032320	65	0.179
myeloid cell homeostasis	GO:0002262	114	0.178
vesicle localization	GO:0051648	86	0.178
regulation of actin filament based process	GO:0032970	99	0.173
negative regulation of bone remodeling	GO:0046851	6	0.172
regulation of cell migration	GO:0030334	219	0.168
cell activation involved in immune response	GO:0002263	126	0.167
regulation of autophagy	GO:0010506	30	0.166
establishment of vesicle localization	GO:0051650	81	0.165
stress activated protein kinase signaling cascade	GO:0031098	81	0.163
modification dependent protein catabolic process	GO:0019941	133	0.163
positive regulation of t cell differentiation	GO:0045582	52	0.163
regulation of lymphocyte activation	GO:0051249	240	0.159
skeletal system development	GO:0001501	356	0.159
organonitrogen compound catabolic process	GO:1901565	264	0.158
regulation of jnk cascade	GO:0046328	62	0.158
regulation of t cell differentiation	GO:0045580	83	0.157
t cell differentiation	GO:0030217	174	0.157
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.155
positive regulation of extrinsic apoptotic signaling pathway	GO:2001238	34	0.155
transmembrane transport	GO:0055085	412	0.155
activation of jun kinase activity	GO:0007257	15	0.155
positive regulation of cell activation	GO:0050867	158	0.154
regulation of cytoskeleton organization	GO:0051493	122	0.153
gtp catabolic process	GO:0006184	143	0.153
immune response activating signal transduction	GO:0002757	116	0.153
endomembrane system organization	GO:0010256	147	0.153
regulation of cell motility	GO:2000145	236	0.152
regulation of epithelial cell proliferation	GO:0050678	141	0.152
male sex differentiation	GO:0046661	109	0.151
glycosyl compound metabolic process	GO:1901657	246	0.151
cellular component assembly involved in morphogenesis	GO:0010927	139	0.150
negative regulation of b cell receptor signaling pathway	GO:0050859	4	0.149
gtp metabolic process	GO:0046039	144	0.149
regulation of apoptotic signaling pathway	GO:2001233	197	0.148
regulation of mast cell degranulation	GO:0043304	16	0.148
mast cell degranulation	GO:0043303	19	0.147
nucleoside phosphate catabolic process	GO:1901292	222	0.147
embryonic organ morphogenesis	GO:0048562	276	0.147
gastrulation	GO:0007369	116	0.146
cellular nitrogen compound catabolic process	GO:0044270	280	0.146
regulation of cellular amino acid metabolic process	GO:0006521	5	0.145
negative regulation of osteoclast differentiation	GO:0045671	12	0.145
regulation of cell projection organization	GO:0031344	206	0.144
maintenance of location	GO:0051235	89	0.144
stress activated mapk cascade	GO:0051403	80	0.143
regulation of terminal button organization	GO:2000331	1	0.142
growth plate cartilage chondrocyte growth	GO:0003430	2	0.142
b cell proliferation	GO:0042100	53	0.138
wnt signaling pathway	GO:0016055	188	0.138
negative regulation of leukocyte proliferation	GO:0070664	46	0.137
jnk cascade	GO:0007254	72	0.136
neuroblast proliferation	GO:0007405	49	0.136
positive regulation of cellular catabolic process	GO:0031331	148	0.136
autophagy	GO:0006914	45	0.133
regulation of nucleoside metabolic process	GO:0009118	130	0.133
tissue remodeling	GO:0048771	102	0.132
spermatid development	GO:0007286	108	0.132
axon extension involved in axon guidance	GO:0048846	14	0.132
lens fiber cell apoptotic process	GO:1990086	4	0.132
lipid localization	GO:0010876	126	0.131
response to uv	GO:0009411	44	0.131
gastrulation with mouth forming second	GO:0001702	29	0.130
negative regulation of kinase activity	GO:0033673	81	0.130
ion transmembrane transport	GO:0034220	361	0.127
protein localization to organelle	GO:0033365	185	0.126
dendritic spine organization	GO:0097061	26	0.126
regulation of membrane potential	GO:0042391	192	0.126
positive regulation of leukocyte degranulation	GO:0043302	10	0.125
regulation of hydrolase activity	GO:0051336	246	0.124
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.123
single organismal cell cell adhesion	GO:0016337	131	0.122
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.120
positive regulation of mast cell degranulation	GO:0043306	10	0.119
placenta development	GO:0001890	140	0.119
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	23	0.118
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.117
regulation of tolerance induction	GO:0002643	10	0.117
negative regulation of protein modification process	GO:0031400	163	0.116
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.116
tissue regeneration	GO:0042246	22	0.115
positive regulation of stress activated mapk cascade	GO:0032874	48	0.114
regulation of erythrocyte differentiation	GO:0045646	23	0.114
regulation of myeloid leukocyte differentiation	GO:0002761	58	0.113
protein import into nucleus	GO:0006606	95	0.112
optic placode formation	GO:0001743	2	0.112
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.112
positive regulation of protein kinase activity	GO:0045860	144	0.111
spermatid differentiation	GO:0048515	115	0.110
regulation of cytoplasmic transport	GO:1903649	112	0.110
ribose phosphate metabolic process	GO:0019693	291	0.110
ruffle organization	GO:0031529	16	0.108
canonical wnt signaling pathway	GO:0060070	130	0.108
positive regulation of b cell differentiation	GO:0045579	13	0.108
regulation of t cell proliferation	GO:0042129	92	0.107
response to endoplasmic reticulum stress	GO:0034976	53	0.107	Worm
response to sterol	GO:0036314	4	0.106
regulation of nucleotide catabolic process	GO:0030811	122	0.106
compound eye development	GO:0048749	1	0.105
regulation of cellular component biogenesis	GO:0044087	181	0.105
angiogenesis	GO:0001525	201	0.105
stem cell development	GO:0048864	219	0.101
lateral mesoderm morphogenesis	GO:0048369	3	0.101
epidermis development	GO:0008544	187	0.101
regulation of dendritic spine morphogenesis	GO:0061001	17	0.100
female sex differentiation	GO:0046660	84	0.099
negative regulation of intracellular signal transduction	GO:1902532	167	0.098
regulation of lymphocyte anergy	GO:0002911	4	0.098
cell chemotaxis	GO:0060326	81	0.097
regulation of leukocyte proliferation	GO:0070663	121	0.097
protein ubiquitination	GO:0016567	171	0.097
positive regulation of lymphocyte anergy	GO:0002913	4	0.097
neuron projection extension involved in neuron projection guidance	GO:1902284	14	0.096
positive regulation of myeloid cell differentiation	GO:0045639	43	0.096
gonad development	GO:0008406	141	0.095
purine ribonucleotide catabolic process	GO:0009154	208	0.095
photoreceptor cell development	GO:0042461	40	0.094
positive regulation of gtp catabolic process	GO:0033126	85	0.094
locomotory behavior	GO:0007626	195	0.094
regulation of osteoclast differentiation	GO:0045670	36	0.094
purine nucleoside catabolic process	GO:0006152	205	0.094
cell aging	GO:0007569	35	0.094
synaptic vesicle endocytosis	GO:0048488	19	0.093
cellular response to epidermal growth factor stimulus	GO:0071364	4	0.093
actin filament polymerization	GO:0030041	44	0.093
positive regulation of immune effector process	GO:0002699	107	0.092
regulation of smad protein import into nucleus	GO:0060390	3	0.092
determination of adult lifespan	GO:0008340	11	0.092
axon guidance	GO:0007411	141	0.091
inositol lipid mediated signaling	GO:0048017	41	0.091
digestive tract morphogenesis	GO:0048546	147	0.090
single organism cell adhesion	GO:0098602	156	0.089
bone resorption	GO:0045453	38	0.089
neural plate mediolateral regionalization	GO:0021998	1	0.088
purine nucleoside metabolic process	GO:0042278	241	0.088
regulation of endocytosis	GO:0030100	69	0.087
myeloid cell activation involved in immune response	GO:0002275	34	0.087
single organism nuclear import	GO:1902593	95	0.086
bronchus morphogenesis	GO:0060434	2	0.086
purine nucleotide metabolic process	GO:0006163	302	0.085
regulation of t cell tolerance induction	GO:0002664	6	0.084
protein import	GO:0017038	101	0.084
response to epidermal growth factor	GO:0070849	4	0.082
multicellular organismal aging	GO:0010259	24	0.082
regulation of secretion by cell	GO:1903530	249	0.082
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.081
purine ribonucleoside metabolic process	GO:0046128	241	0.081
positive regulation of programmed cell death	GO:0043068	218	0.081
tor signaling	GO:0031929	21	0.081	Fly
cellular response to amino acid stimulus	GO:0071230	29	0.081
negative regulation of bone resorption	GO:0045779	6	0.081
negative regulation of homeostatic process	GO:0032845	71	0.080
positive regulation of b cell tolerance induction	GO:0002663	2	0.080
hexose metabolic process	GO:0019318	98	0.080
activation of immune response	GO:0002253	138	0.079
regulation of cell projection assembly	GO:0060491	38	0.078
regulation of t cell anergy	GO:0002667	4	0.078
response to radiation	GO:0009314	165	0.078
positive regulation of smad protein import into nucleus	GO:0060391	2	0.078
mitotic cell cycle process	GO:1903047	159	0.077
proteasomal protein catabolic process	GO:0010498	98	0.077
cellular response to insulin stimulus	GO:0032869	78	0.077	Rat
regulation of cellular ketone metabolic process	GO:0010565	66	0.077
response to cholesterol	GO:0070723	4	0.076
cellular protein catabolic process	GO:0044257	155	0.076
camera type eye development	GO:0043010	266	0.076
mast cell activation involved in immune response	GO:0002279	20	0.076
positive regulation of erythrocyte differentiation	GO:0045648	11	0.076
molting cycle	GO:0042303	90	0.076
positive regulation of lymphocyte differentiation	GO:0045621	61	0.075
phosphatidylinositol biosynthetic process	GO:0006661	15	0.075
bone morphogenesis	GO:0060349	78	0.075
positive regulation of protein import into nucleus	GO:0042307	26	0.075
negative regulation of cell development	GO:0010721	169	0.075
activation of mapkk activity	GO:0000186	15	0.075
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.075
negative regulation of antigen receptor mediated signaling pathway	GO:0050858	16	0.075
regulation of protein catabolic process	GO:0042176	108	0.074
cell recognition	GO:0008037	83	0.073
regulation of purine nucleotide catabolic process	GO:0033121	122	0.073
mammary gland morphogenesis	GO:0060443	54	0.073
response to calcium ion	GO:0051592	20	0.073
negative regulation of transferase activity	GO:0051348	85	0.072
modification dependent macromolecule catabolic process	GO:0043632	133	0.072
regulation of neuronal synaptic plasticity	GO:0048168	30	0.071
regulation of anti mullerian hormone signaling pathway	GO:1902612	1	0.071
regulation of stress activated mapk cascade	GO:0032872	69	0.071
actin cytoskeleton reorganization	GO:0031532	21	0.070
activation of ras gtpase activity	GO:0032856	11	0.069
regulation of cell adhesion	GO:0030155	154	0.069
macrophage differentiation	GO:0030225	20	0.069
morphogenesis of a branching structure	GO:0001763	203	0.069
stem cell maintenance	GO:0019827	130	0.069
nucleoside triphosphate metabolic process	GO:0009141	230	0.069
regulated secretory pathway	GO:0045055	32	0.067
organophosphate biosynthetic process	GO:0090407	122	0.067
leukocyte mediated immunity	GO:0002443	174	0.067
bone remodeling	GO:0046849	53	0.067
regulation of muscle tissue development	GO:1901861	97	0.067
inorganic ion transmembrane transport	GO:0098660	234	0.066
purine containing compound catabolic process	GO:0072523	213	0.066
epithelial tube morphogenesis	GO:0060562	303	0.066
cellular senescence	GO:0090398	11	0.066
mitochondrion organization	GO:0007005	134	0.065
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	13	0.065
positive regulation of t cell mediated cytotoxicity	GO:0001916	15	0.065
regulation of synaptic vesicle recycling	GO:1903421	2	0.065
dendritic spine development	GO:0060996	30	0.064
innate immune response	GO:0045087	157	0.064	Fly
immunoglobulin mediated immune response	GO:0016064	69	0.064
optic placode formation involved in camera type eye formation	GO:0046619	2	0.064
positive regulation of cellular protein catabolic process	GO:1903364	34	0.064
mullerian duct regression	GO:0001880	1	0.064
regulation of purine nucleotide metabolic process	GO:1900542	169	0.063
cellular amine metabolic process	GO:0044106	44	0.062
membrane organization	GO:0061024	245	0.062
circulatory system process	GO:0003013	197	0.062	Rat
insulin secretion	GO:0030073	89	0.062
inorganic cation transmembrane transport	GO:0098662	207	0.062
response to monosaccharide	GO:0034284	67	0.062
sequestering of metal ion	GO:0051238	19	0.062
glycerolipid metabolic process	GO:0046486	122	0.062
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	40	0.061
positive regulation of mitotic cell cycle	GO:0045931	41	0.061
lateral mesodermal cell differentiation	GO:0048371	3	0.061
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.060
positive regulation of proteolysis	GO:0045862	85	0.060
lymphocyte anergy	GO:0002249	4	0.060
ruffle assembly	GO:0097178	13	0.060
regulation of exocytosis	GO:0017157	61	0.060
carbohydrate metabolic process	GO:0005975	230	0.060
tolerance induction to self antigen	GO:0002513	4	0.060
nucleobase containing small molecule metabolic process	GO:0055086	352	0.060
anti mullerian hormone signaling pathway	GO:1990262	1	0.059
positive regulation of nucleoside metabolic process	GO:0045979	91	0.059
negative regulation of molecular function	GO:0044092	258	0.059
regulation of rac protein signal transduction	GO:0035020	19	0.059
cellular homeostasis	GO:0019725	240	0.058
maintenance of protein location in nucleus	GO:0051457	2	0.058
actin polymerization or depolymerization	GO:0008154	54	0.058
organelle assembly	GO:0070925	177	0.058
endochondral bone morphogenesis	GO:0060350	50	0.058
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	31	0.058
regulation of cell size	GO:0008361	72	0.058
negative regulation of protein metabolic process	GO:0051248	282	0.057
peptidyl threonine modification	GO:0018210	31	0.057
trivalent inorganic cation transport	GO:0072512	5	0.057
positive regulation of skeletal muscle tissue regeneration	GO:0043415	4	0.057
positive regulation of exocytosis	GO:0045921	20	0.057
negative regulation of ras protein signal transduction	GO:0046580	18	0.056
b cell tolerance induction	GO:0002514	2	0.056
fatty acid metabolic process	GO:0006631	121	0.056
negative regulation of lymphocyte activation	GO:0051250	91	0.055
regulation of neutrophil differentiation	GO:0045658	2	0.055
regulation of excitatory postsynaptic membrane potential	GO:0060079	41	0.055
spermatogenesis	GO:0007283	284	0.055
regulation of protein localization	GO:0032880	231	0.055
g protein coupled receptor signaling pathway	GO:0007186	243	0.055
branching morphogenesis of an epithelial tube	GO:0048754	159	0.055
male gamete generation	GO:0048232	285	0.054
regulation of hormone levels	GO:0010817	211	0.054
blastocyst development	GO:0001824	80	0.054
positive regulation of protein localization to nucleus	GO:1900182	30	0.054
positive regulation of cell cycle	GO:0045787	92	0.054
mitochondrion localization	GO:0051646	9	0.054
regulation of b cell tolerance induction	GO:0002661	2	0.053
engulfment of apoptotic cell	GO:0043652	3	0.053
cellular response to cytokine stimulus	GO:0071345	189	0.053
regulation of erk1 and erk2 cascade	GO:0070372	71	0.052
reactive oxygen species metabolic process	GO:0072593	84	0.052
regulation of embryonic development	GO:0045995	71	0.052
myosin filament assembly	GO:0031034	2	0.052
sulfur compound metabolic process	GO:0006790	100	0.052
renal system development	GO:0072001	225	0.052
exocytosis	GO:0006887	121	0.052
epithelial cell proliferation	GO:0050673	174	0.051

Shc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
cancer	DOID:162	0.222
disease of cellular proliferation	DOID:14566	0.222
organ system cancer	DOID:0050686	0.142
gastrointestinal system cancer	DOID:3119	0.061

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