Mus musculus

0 known processes

Mthfd2

methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase

(Aliases: NMDMC,AW558851)

Mthfd2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
methionine transportGO:001582110.628
amino acid transmembrane transportGO:0003333370.581
l alpha amino acid transmembrane transportGO:1902475230.392
anion transmembrane transportGO:0098656710.254
neutral amino acid transportGO:0015804130.219
branched chain amino acid transportGO:001580320.199
organic acid transportGO:00158491010.169
cellular amino acid metabolic processGO:00065201030.157
Human
l amino acid transportGO:0015807320.151
anion transportGO:00068201770.145
nitrogen compound transportGO:00717052710.107
cation transportGO:00068123990.099
ion transmembrane transportGO:00342203610.096
carboxylic acid transportGO:00469421000.085
nucleoside phosphate metabolic processGO:00067533380.084
dna metabolic processGO:00062593030.070
cellular amine metabolic processGO:0044106440.068
organic anion transportGO:00157111370.067
organonitrogen compound biosynthetic processGO:19015661920.064
translationGO:0006412930.055
nucleobase containing small molecule metabolic processGO:00550863520.053
cellular ketone metabolic processGO:0042180840.053
amino acid activationGO:004303810.051
regulation of cellular amine metabolic processGO:0033238200.050
monocarboxylic acid metabolic processGO:00327871910.049
amino acid transportGO:0006865610.049
amine metabolic processGO:0009308450.048
regulation of cellular amino acid metabolic processGO:000652150.043
response to organic cyclic compoundGO:00140701980.040
ribose phosphate metabolic processGO:00196932910.040
organophosphate biosynthetic processGO:00904071220.040
dna repairGO:00062811070.039
reactive oxygen species metabolic processGO:0072593840.039
sulfur compound transportGO:007234890.039
transmembrane transportGO:00550854120.038
oxidation reduction processGO:00551143420.038
Human
ossificationGO:00015032160.037
regulation of cellular ketone metabolic processGO:0010565660.036
sulfur amino acid transportGO:000010120.036
cellular response to organonitrogen compoundGO:00714171450.035
microtubule based processGO:00070172360.034
positive regulation of cellular amino acid metabolic processGO:004576430.033
macromolecule catabolic processGO:00090572810.033
alpha amino acid metabolic processGO:1901605590.033
Human
response to organonitrogen compoundGO:00102432460.033
nuclear divisionGO:00002801580.033
nucleotide metabolic processGO:00091173320.032
organelle fissionGO:00482851700.031
apoptotic signaling pathwayGO:00971903060.031
carboxylic acid biosynthetic processGO:0046394860.031
response to radiationGO:00093141650.031
chromatin organizationGO:00063252060.029
male gamete generationGO:00482322850.029
positive regulation of cellular catabolic processGO:00313311480.028
cellular homeostasisGO:00197252400.028
microtubule cytoskeleton organizationGO:00002261570.027
regulation of cellular catabolic processGO:00313292420.027
negative regulation of protein metabolic processGO:00512482820.027
carbohydrate metabolic processGO:00059752300.027
rhythmic processGO:00485111740.027
nucleoside triphosphate metabolic processGO:00091412300.027
cellular response to dna damage stimulusGO:00069742070.026
mitotic cell cycle processGO:19030471590.026
spermatogenesisGO:00072832840.026
cellular response to cytokine stimulusGO:00713451890.026
neuron apoptotic processGO:00514021420.025
response to acid chemicalGO:00011011110.024
cellular lipid metabolic processGO:00442553230.024
cell type specific apoptotic processGO:00972852680.024
meiotic cell cycle processGO:1903046770.023
regulation of cell cycleGO:00517262810.023
negative regulation of molecular functionGO:00440922580.023
striated muscle tissue developmentGO:00147062930.022
regulation of mitotic cell cycleGO:00073461260.022
small molecule biosynthetic processGO:00442831320.022
negative regulation of cellular protein metabolic processGO:00322692470.022
sensory organ morphogenesisGO:00905962420.022
carbohydrate homeostasisGO:00335001280.021
regulation of cell divisionGO:0051302760.021
cellular chemical homeostasisGO:00550822150.021
chromatin modificationGO:00165681870.021
regulation of cell cycle processGO:00105641600.021
t cell activationGO:00421102890.021
lipid biosynthetic processGO:00086101790.021
neuron deathGO:00709971540.021
forebrain developmentGO:00309003020.020
positive regulation of cell cycleGO:0045787920.020
protein catabolic processGO:00301632210.019
positive regulation of cellular amine metabolic processGO:003324050.019
mitotic nuclear divisionGO:0007067480.019
regulation of organelle organizationGO:00330432890.019
muscle cell differentiationGO:00426922610.019
cellular protein catabolic processGO:00442571550.019
carbohydrate derivative catabolic processGO:19011362310.019
muscle tissue developmentGO:00605373080.019
response to light stimulusGO:00094161350.018
skeletal system developmentGO:00015013560.018
reactive nitrogen species metabolic processGO:200105700.018
positive regulation of cell developmentGO:00107202370.018
ribonucleoside triphosphate metabolic processGO:00091992200.018
response to inorganic substanceGO:0010035960.018
myeloid cell differentiationGO:00300992330.018
regulation of secretion by cellGO:19035302490.018
maintenance of locationGO:0051235890.018
glycosyl compound metabolic processGO:19016572460.018
gland developmentGO:00487323300.018
monosaccharide metabolic processGO:00059961060.017
cation transmembrane transportGO:00986552660.017
myeloid leukocyte differentiationGO:00025731190.017
germ cell developmentGO:00072811850.017
small gtpase mediated signal transductionGO:0007264970.017
circadian rhythmGO:00076231140.017
digestive system developmentGO:00551232000.017
positive regulation of programmed cell deathGO:00430682180.017
hormone secretionGO:00468791280.017
carbohydrate derivative biosynthetic processGO:19011371830.017
dna recombinationGO:0006310920.017
regulation of cell activationGO:00508652890.016
lymphocyte proliferationGO:00466511640.016
ribonucleoside triphosphate catabolic processGO:00092031990.016
regulation of homeostatic processGO:00328441820.016
purine ribonucleotide metabolic processGO:00091502900.016
reactive oxygen species biosynthetic processGO:190340980.016
hexose metabolic processGO:0019318980.016
regulation of hormone levelsGO:00108172110.016
divalent metal ion transportGO:00708381720.016
positive regulation of protein modification processGO:00314012990.016
cellular macromolecule catabolic processGO:00442652060.016
mapk cascadeGO:00001652810.016
protein processingGO:00164851630.016
intrinsic apoptotic signaling pathwayGO:00971931320.016
sensory perceptionGO:00076002450.016
amide transportGO:00428861380.015
negative regulation of cell proliferationGO:00082852960.015
regulation of membrane potentialGO:00423911920.015
regulation of nucleotide metabolic processGO:00061401690.015
leukocyte differentiationGO:00025213420.015
positive regulation of chromosome segregationGO:005198440.015
organic acid biosynthetic processGO:0016053860.015
urogenital system developmentGO:00016552610.015
neuromuscular processGO:0050905990.015
negative regulation of cellular component organizationGO:00511291940.015
cytokine productionGO:00018163190.015
defense response to other organismGO:00985421970.015
meiotic cell cycleGO:00513211220.015
positive regulation of cell deathGO:00109422240.015
t cell proliferationGO:00420981200.015
b cell activationGO:00421131610.015
purine ribonucleoside metabolic processGO:00461282410.015
protein methylationGO:0006479810.015
macromolecule methylationGO:00434141200.015
homeostasis of number of cellsGO:00488722100.014
purine containing compound metabolic processGO:00725213110.014
fatty acid metabolic processGO:00066311210.014
positive regulation of organelle organizationGO:00106381280.014
mitotic cell cycleGO:00002781950.014
organophosphate catabolic processGO:00464342320.014
aromatic compound catabolic processGO:00194392860.014
negative regulation of cellular amino acid metabolic processGO:004576300.014
membrane organizationGO:00610242450.014
negative regulation of cellular amine metabolic processGO:003323910.014
sequestering of metal ionGO:0051238190.014
regulation of nucleoside metabolic processGO:00091181300.014
regulation of cellular component sizeGO:00325351210.014
sequestering of calcium ionGO:0051208180.014
trna aminoacylationGO:004303910.014
positive regulation of apoptotic processGO:00430652170.014
regulation of neuron differentiationGO:00456642810.014
inflammatory responseGO:00069542440.014
dna endoreduplicationGO:004202340.014
glucose homeostasisGO:00425931280.014
ras protein signal transductionGO:0007265770.014
connective tissue developmentGO:00614481790.014
organic cyclic compound catabolic processGO:19013612950.014
cellular carbohydrate metabolic processGO:00442621190.014
protein ubiquitinationGO:00165671710.014
glucose metabolic processGO:0006006920.014
regulation of protein catabolic processGO:00421761080.013
regulation of purine nucleotide metabolic processGO:19005421690.013
purine nucleoside metabolic processGO:00422782410.013
multicellular organism growthGO:00352641610.013
response to extracellular stimulusGO:00099911270.013
peptide transportGO:00158331330.013
purine nucleoside triphosphate metabolic processGO:00091442260.013
regulation of reactive oxygen species metabolic processGO:2000377400.013
leukocyte proliferationGO:00706611720.013
protein alkylationGO:0008213810.013
circadian regulation of gene expressionGO:0032922480.013
cell maturationGO:00484691270.013
carbohydrate biosynthetic processGO:0016051740.013
cell adhesionGO:00071553290.013
ribonucleoside metabolic processGO:00091192450.013
ribonucleotide metabolic processGO:00092592910.013
coenzyme metabolic processGO:0006732520.013
Human
cellular response to acid chemicalGO:0071229680.013
regulation of protein kinase activityGO:00458592320.013
compound eye developmentGO:004874910.013
histone modificationGO:00165701590.013
methylationGO:00322591340.013
skeletal muscle organ developmentGO:00605381630.012
regulation of cytokine productionGO:00018172660.012
cytoplasmic transportGO:00164822340.012
purine nucleoside triphosphate catabolic processGO:00091462030.012
cellular response to lipidGO:00713961450.012
regulation of response to woundingGO:19030341890.012
regulation of transferase activityGO:00513382630.012
nucleotide catabolic processGO:00091662170.012
regulation of apoptotic signaling pathwayGO:20012331970.012
nucleoside catabolic processGO:00091642060.012
regulation of chromosome organizationGO:0033044830.012
positive regulation of purine nucleotide metabolic processGO:19005441140.012
peptidyl amino acid modificationGO:00181933360.012
cellular response to hormone stimulusGO:00328701500.012
regulation of proteolysisGO:00301621640.012
regulation of cell adhesionGO:00301551540.012
cellular biogenic amine metabolic processGO:0006576280.012
mitochondrion organizationGO:00070051340.012
camera type eye developmentGO:00430102660.012
amino acid import into cellGO:190283740.012
regulation of cell projection organizationGO:00313442060.012
attachment of spindle microtubules to kinetochoreGO:000860840.012
chromosome organization involved in meiosisGO:0070192390.012
positive regulation of nucleotide metabolic processGO:00459811140.012
respiratory tube developmentGO:00303231670.012
cellular component assembly involved in morphogenesisGO:00109271390.012
calcium ion transportGO:00068161590.012
positive regulation of protein phosphorylationGO:00019342420.012
regulation of proteasomal protein catabolic processGO:0061136460.012
single organism cell adhesionGO:00986021560.012
regulation of secretionGO:00510462740.012
negative regulation of cell developmentGO:00107211690.012
response to nutrient levelsGO:00316671090.012
sulfur compound metabolic processGO:00067901000.012
proteolysis involved in cellular protein catabolic processGO:00516031470.012
nucleocytoplasmic transportGO:00069131390.011
cell activation involved in immune responseGO:00022631260.011
actin cytoskeleton organizationGO:00300362200.011
cellular response to abiotic stimulusGO:0071214560.011
response to amino acidGO:0043200370.011
metal ion homeostasisGO:00550651890.011
regulation of mapk cascadeGO:00434082480.011
peptide hormone secretionGO:00300721090.011
regulation of hydrolase activityGO:00513362460.011
positive regulation of leukocyte differentiationGO:1902107860.011
male sex differentiationGO:00466611090.011
cellular metal ion homeostasisGO:00068751510.011
nucleoside metabolic processGO:00091162460.011
response to peptideGO:19016521360.011
anatomical structure homeostasisGO:00602491450.011
cellular amino acid biosynthetic processGO:0008652220.011
regulation of cell migrationGO:00303342190.011
regulation of anatomical structure sizeGO:00900661780.011
myosin filament assemblyGO:003103420.011
protein maturationGO:00516041760.011
response to oxidative stressGO:00069791230.011
regulation of leukocyte differentiationGO:19021051590.011
glycosyl compound catabolic processGO:19016582060.011
alcohol metabolic processGO:00060661160.011
lung developmentGO:00303241640.011
regulation of cytoskeleton organizationGO:00514931220.011
lymphocyte differentiationGO:00300982420.011
negative regulation of protein modification processGO:00314001630.011
leukocyte mediated immunityGO:00024431740.011
regulation of kinase activityGO:00435492490.011
regulation of nucleotide catabolic processGO:00308111220.011
regulation of cell sizeGO:0008361720.011
organonitrogen compound catabolic processGO:19015652640.011
purine containing compound catabolic processGO:00725232130.011
nucleoside phosphate catabolic processGO:19012922220.011
renal system developmentGO:00720012250.011
protein modification by small protein conjugation or removalGO:00706472070.011
covalent chromatin modificationGO:00165691630.010
positive regulation of protein kinase activityGO:00458601440.010
organism emergence from protective structureGO:007168440.010
innate immune responseGO:00450871570.010
regulation of protein serine threonine kinase activityGO:00719001570.010
kidney developmentGO:00018222130.010
posttranscriptional regulation of gene expressionGO:00106081550.010
cofactor metabolic processGO:0051186800.010
Human
positive regulation of cell activationGO:00508671580.010
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630570.010
modification dependent macromolecule catabolic processGO:00436321330.010
leukocyte apoptotic processGO:0071887710.010
response to peptide hormoneGO:00434341270.010
response to insulinGO:00328681000.010
regulation of wnt signaling pathwayGO:00301111230.010
ribose phosphate biosynthetic processGO:0046390590.010
cytokine mediated signaling pathwayGO:00192211150.010
regulation of cell motilityGO:20001452360.010
ribonucleoside catabolic processGO:00424542060.010

Mthfd2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.172
nervous system diseaseDOID:86300.172
neuropathyDOID:87000.172
neuromuscular diseaseDOID:44000.085
disease of cellular proliferationDOID:1456600.042
cancerDOID:16200.025
charcot marie tooth disease type 2DOID:005053900.023
charcot marie tooth diseaseDOID:1059500.023
central nervous system diseaseDOID:33100.022
neurodegenerative diseaseDOID:128900.021
organ system cancerDOID:005068600.019
disease of metabolismDOID:001466700.015
immune system diseaseDOID:291400.012
inherited metabolic disorderDOID:65500.010