Mus musculus

6 known processes

Spast

spastin

(Aliases: mKIAA1083,Spg4)

Spast biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
protein modification by small protein conjugationGO:00324461870.199
cellular macromolecule catabolic processGO:00442652060.153
macromolecule catabolic processGO:00090572810.124
modification dependent protein catabolic processGO:00199411330.117
protein modification by small protein conjugation or removalGO:00706472070.106
proteolysis involved in cellular protein catabolic processGO:00516031470.095
organic cyclic compound catabolic processGO:19013612950.087
Human Fly
covalent chromatin modificationGO:00165691630.079
small gtpase mediated signal transductionGO:0007264970.079
cellular protein catabolic processGO:00442571550.075
gene silencingGO:0016458380.073
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.073
protein ubiquitinationGO:00165671710.072
protein localization to organelleGO:00333651850.071
regulation of protein transportGO:00512231630.066
proteasomal protein catabolic processGO:0010498980.065
male gamete generationGO:00482322850.061
ras protein signal transductionGO:0007265770.061
protein catabolic processGO:00301632210.061
organelle assemblyGO:00709251770.059
establishment of protein localization to organelleGO:00725941180.058
ubiquitin dependent protein catabolic processGO:00065111290.058
positive regulation of nfat protein import into nucleusGO:005153310.057
regulation of cellular catabolic processGO:00313292420.056
regulation of protein localizationGO:00328802310.056
nuclear transportGO:00511691390.056
regulation of cellular component biogenesisGO:00440871810.054
Fly
regulation of synaptic growth at neuromuscular junctionGO:000858240.053
Fly
chromatin modificationGO:00165681870.053
membrane organizationGO:00610242450.052
forebrain developmentGO:00309003020.051
regulation of organelle organizationGO:00330432890.049
Zebrafish Fly
mapk cascadeGO:00001652810.049
regulation of cellular amino acid metabolic processGO:000652150.049
response to growth factorGO:00708481980.048
cellular response to growth factor stimulusGO:00713631970.048
nucleoside phosphate catabolic processGO:19012922220.047
Human Fly
posttranscriptional regulation of gene expressionGO:00106081550.047
purine nucleoside catabolic processGO:00061522050.046
Human Fly
axonogenesisGO:00074092740.045
Zebrafish
regulation of cellular amine metabolic processGO:0033238200.045
chromatin organizationGO:00063252060.044
nucleocytoplasmic transportGO:00069131390.044
chemotaxisGO:00069352470.044
regulation of establishment of protein localizationGO:00702011810.044
purine nucleoside triphosphate catabolic processGO:00091462030.044
Human Fly
regulation of cell motilityGO:20001452360.043
negative regulation of cellular protein metabolic processGO:00322692470.042
dna metabolic processGO:00062593030.041
protein targetingGO:00066051430.041
striated muscle tissue developmentGO:00147062930.041
cellular response to dna damage stimulusGO:00069742070.041
transforming growth factor beta receptor signaling pathwayGO:0007179710.040
compound eye developmentGO:004874910.040
ribonucleotide metabolic processGO:00092592910.039
Human Fly
carbohydrate derivative catabolic processGO:19011362310.039
Human Fly
histone modificationGO:00165701590.039
nuclear importGO:0051170950.038
negative regulation of mitotic cell cycleGO:0045930580.037
cellular response to transforming growth factor beta stimulusGO:0071560880.037
protein importGO:00170381010.037
intracellular protein transportGO:00068862040.037
cellular amine metabolic processGO:0044106440.037
multicellular organism growthGO:00352641610.035
negative regulation of synapse assemblyGO:005196430.035
Fly
negative regulation of cell cycleGO:00457861230.035
nucleotide metabolic processGO:00091173320.034
Human Fly
single organism nuclear importGO:1902593950.033
negative regulation of protein modification processGO:00314001630.033
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.033
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.033
homeostasis of number of cellsGO:00488722100.032
peptidyl amino acid modificationGO:00181933360.032
immune effector processGO:00022523210.032
g1 s transition of mitotic cell cycleGO:0000082570.032
ribonucleoside triphosphate metabolic processGO:00091992200.032
Human Fly
response to transforming growth factor betaGO:0071559880.032
amine metabolic processGO:0009308450.031
negative regulation of protein metabolic processGO:00512482820.031
regulation of intracellular transportGO:00323861590.030
purine containing compound metabolic processGO:00725213110.030
Human Fly
cellular amino acid metabolic processGO:00065201030.030
microtubule severingGO:005101350.030
organophosphate catabolic processGO:00464342320.030
Human Fly
cellular ketone metabolic processGO:0042180840.030
regulation of cell migrationGO:00303342190.030
cell divisionGO:00513011200.029
Human
protein polyubiquitinationGO:0000209330.029
positive regulation of cell migrationGO:00303351090.029
regulation of mitotic cell cycleGO:00073461260.029
heterocycle catabolic processGO:00467002800.028
Human Fly
purine ribonucleoside catabolic processGO:00461302050.028
Human Fly
amide transportGO:00428861380.028
aromatic compound catabolic processGO:00194392860.028
Human Fly
nucleoside phosphate metabolic processGO:00067533380.028
Human Fly
purine ribonucleoside metabolic processGO:00461282410.028
Human Fly
positive regulation of cellular catabolic processGO:00313311480.028
maintenance of locationGO:0051235890.028
negative regulation of protein phosphorylationGO:00019331260.028
purine ribonucleoside triphosphate catabolic processGO:00092071990.027
Human Fly
purine nucleotide catabolic processGO:00061952110.027
Human Fly
purine nucleoside metabolic processGO:00422782410.027
Human Fly
regulation of cytoplasmic transportGO:19036491120.027
purine nucleoside triphosphate metabolic processGO:00091442260.027
Human Fly
regulation of cellular response to growth factor stimulusGO:0090287820.027
muscle cell differentiationGO:00426922610.027
protein localization to nucleusGO:00345041210.027
regulation of cellular ketone metabolic processGO:0010565660.027
spermatogenesisGO:00072832840.027
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.027
ribonucleoside triphosphate catabolic processGO:00092031990.026
Human Fly
organelle localizationGO:00516401790.026
synapse organizationGO:00508081250.026
Fly
endomembrane system organizationGO:00102561470.026
Zebrafish
pallium developmentGO:00215431200.026
muscle tissue developmentGO:00605373080.025
leukocyte differentiationGO:00025213420.025
telencephalon developmentGO:00215371860.025
protein import into nucleusGO:0006606950.025
response to radiationGO:00093141650.025
negative regulation of phosphorylationGO:00423261660.025
positive regulation of nucleotide metabolic processGO:00459811140.025
regulation of protein catabolic processGO:00421761080.025
negative regulation of cell cycle phase transitionGO:1901988480.025
positive regulation of cellular amino acid metabolic processGO:004576430.025
negative regulation of phosphate metabolic processGO:00459361840.024
regionalizationGO:00030023370.024
gtp metabolic processGO:00460391440.024
regulation of protein import into nucleusGO:0042306520.024
response to light stimulusGO:00094161350.024
negative regulation of mitotic cell cycle phase transitionGO:1901991450.024
regulation of defense responseGO:00313472330.024
stem cell differentiationGO:00488632680.024
nitrogen compound transportGO:00717052710.024
carbon catabolite regulation of transcriptionGO:004599040.024
stem cell maintenanceGO:00198271300.024
synaptic transmissionGO:00072683290.024
Fly
regulation of mapk cascadeGO:00434082480.024
protein localization to membraneGO:00726571080.023
negative regulation of immune system processGO:00026832090.023
microtubule based processGO:00070172360.023
defense response to other organismGO:00985421970.023
hindbrain developmentGO:00309021280.023
ribonucleotide catabolic processGO:00092612080.023
Human Fly
regulation of cell cycle processGO:00105641600.022
cell type specific apoptotic processGO:00972852680.022
nucleotide catabolic processGO:00091662170.022
Human Fly
modification dependent macromolecule catabolic processGO:00436321330.022
regulation of ras protein signal transductionGO:00465781140.022
negative regulation of phosphorus metabolic processGO:00105631840.022
skeletal muscle organ developmentGO:00605381630.022
nucleobase containing small molecule metabolic processGO:00550863520.021
Human Fly
regulation of nucleotide catabolic processGO:00308111220.021
regulation of cellular component sizeGO:00325351210.021
Zebrafish
germ cell developmentGO:00072811850.021
learning or memoryGO:00076111480.021
actin cytoskeleton organizationGO:00300362200.021
ribose phosphate metabolic processGO:00196932910.021
Human Fly
spermatid developmentGO:00072861080.021
negative regulation of cell developmentGO:00107211690.020
rna processingGO:00063961050.020
regulation of cell cycleGO:00517262810.020
regulation of nucleocytoplasmic transportGO:0046822730.019
positive regulation of protein modification processGO:00314012990.019
endocytosisGO:00068971680.019
nucleoside metabolic processGO:00091162460.019
Human Fly
t cell differentiationGO:00302171740.019
regulation of cytokine productionGO:00018172660.019
regulation of secretionGO:00510462740.019
purine nucleotide metabolic processGO:00061633020.019
Human Fly
cerebellum developmentGO:0021549770.019
regulation of multi organism processGO:00439001110.018
developmental growth involved in morphogenesisGO:00605601380.018
Zebrafish
regulation of transcription factor import into nucleusGO:0042990240.018
metencephalon developmentGO:0022037890.018
transmission of nerve impulseGO:0019226760.018
hematopoietic progenitor cell differentiationGO:00022441430.018
glycosyl compound metabolic processGO:19016572460.018
Human Fly
methylationGO:00322591340.018
regulation of transforming growth factor beta receptor signaling pathwayGO:0017015430.018
dna repairGO:00062811070.018
gene silencing by rnaGO:0031047190.018
olfactory learningGO:000835520.018
epithelial cell migrationGO:0010631630.017
ribonucleoside metabolic processGO:00091192450.017
Human Fly
positive regulation of protein catabolic processGO:0045732600.017
negative regulation of cell cycle processGO:0010948690.017
regulation of kinase activityGO:00435492490.017
adaptive immune responseGO:00022501550.017
regulation of nucleoside metabolic processGO:00091181300.017
cellular nitrogen compound catabolic processGO:00442702800.017
Human Fly
purine ribonucleotide metabolic processGO:00091502900.017
Human Fly
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.017
cytokine productionGO:00018163190.017
positive regulation of growthGO:00459271040.017
Zebrafish Fly
t cell activationGO:00421102890.017
ribonucleoside catabolic processGO:00424542060.017
Human Fly
nucleoside triphosphate metabolic processGO:00091412300.016
Human Fly
regulation of translationGO:0006417710.016
cellular component assembly involved in morphogenesisGO:00109271390.016
carbon catabolite activation of transcriptionGO:004599140.016
digestive system developmentGO:00551232000.016
axon guidanceGO:00074111410.016
cellular homeostasisGO:00197252400.016
negative regulation of transforming growth factor beta receptor signaling pathwayGO:0030512260.016
lateral inhibitionGO:004633110.015
neuron migrationGO:00017641220.015
stem cell developmentGO:00488642190.015
protein autophosphorylationGO:0046777610.015
transmembrane transportGO:00550854120.015
macromolecule methylationGO:00434141200.015
posttranscriptional gene silencingGO:0016441100.015
negative regulation of cell proliferationGO:00082852960.015
nucleoside catabolic processGO:00091642060.015
Human Fly
positive regulation of purine nucleotide catabolic processGO:0033123880.015
rna interferenceGO:001624620.015
regulation of muscle system processGO:0090257800.015
mitotic cell cycleGO:00002781950.015
Fly
oocyte axis specificationGO:000730920.015
regulation of protein localization to nucleusGO:1900180600.015
locomotory behaviorGO:00076261950.015
Fly
lung developmentGO:00303241640.015
regulation of hormone levelsGO:00108172110.015
tissue migrationGO:0090130680.015
positive regulation of purine nucleotide metabolic processGO:19005441140.015
purine ribonucleotide catabolic processGO:00091542080.015
Human Fly
cell growthGO:00160491300.015
Zebrafish
regulation of ras gtpase activityGO:0032318880.015
negative regulation of gene expression epigeneticGO:0045814150.015
lymphocyte mediated immunityGO:00024491390.015
positive regulation of cytoplasmic transportGO:1903651400.014
cellular response to organonitrogen compoundGO:00714171450.014
negative regulation of intracellular signal transductionGO:19025321670.014
ameboidal type cell migrationGO:00016671280.014
spermatid differentiationGO:00485151150.014
negative regulation of molecular functionGO:00440922580.014
peptide transportGO:00158331330.014
regulation of secretion by cellGO:19035302490.014
neuron projection guidanceGO:00974851410.014
organonitrogen compound catabolic processGO:19015652640.014
Human Fly
mitotic cell cycle checkpointGO:0007093310.014
regulation of anatomical structure sizeGO:00900661780.014
Zebrafish
development of primary sexual characteristicsGO:00451371430.014
learningGO:0007612980.014
myeloid cell homeostasisGO:00022621140.014
positive regulation of hydrolase activityGO:00513451480.014
protein k48 linked ubiquitinationGO:007093670.014
positive regulation of nucleotide catabolic processGO:0030813880.014
cellularizationGO:000734910.014
lipid localizationGO:00108761260.014
digestive tract developmentGO:00485651900.014
regulation of protein targetingGO:1903533610.014
negative regulation of nervous system developmentGO:00519611560.014
Fly
chromatin silencingGO:0006342150.014
response to inorganic substanceGO:0010035960.013
hormone secretionGO:00468791280.013
divalent metal ion transportGO:00708381720.013
regulation of actin filament based processGO:0032970990.013
regulation of cellular response to stressGO:00801351590.013
exocytosisGO:00068871210.013
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101610.013
nucleoside triphosphate catabolic processGO:00091432050.013
Human Fly
positive regulation of cellular amine metabolic processGO:003324050.013
respiratory system developmentGO:00605411900.013
anatomical structure homeostasisGO:00602491450.013
actin filament organizationGO:00070151130.013
germline cell cycle switching mitotic to meiotic cell cycleGO:005172910.013
gtp catabolic processGO:00061841430.013
regulation of cell sizeGO:0008361720.013
Zebrafish
cognitionGO:00508901490.013
positive regulation of proteolysis involved in cellular protein catabolic processGO:1903052310.013
mitotic cell cycle processGO:19030471590.013
Fly
regulation of mitotic cell cycle phase transitionGO:1901990730.013
cation transportGO:00068123990.013
lymphocyte differentiationGO:00300982420.013
positive regulation of protein phosphorylationGO:00019342420.013
regulation of cell activationGO:00508652890.013
regulation of cell morphogenesis involved in differentiationGO:00107691510.013
Zebrafish Fly
regulation of system processGO:00440572000.013
adult behaviorGO:00305341350.012
peptide hormone secretionGO:00300721090.012
skeletal system developmentGO:00015013560.012
positive regulation of nucleoside metabolic processGO:0045979910.012
jnk cascadeGO:0007254720.012
negative regulation of mapk cascadeGO:0043409650.012
regulation of membrane potentialGO:00423911920.012
regulation of t cell activationGO:00508631700.012
positive regulation of intracellular transportGO:0032388700.012
regulation of hydrolase activityGO:00513362460.012
nuclear divisionGO:00002801580.012
Fly
digestive tract morphogenesisGO:00485461470.012
response to insulinGO:00328681000.012
regulation of cell cycle phase transitionGO:1901987770.012
regulation of leukocyte differentiationGO:19021051590.012
positive regulation of cellular component biogenesisGO:0044089940.012
Fly
regulation of chromosome organizationGO:0033044830.012
cell adhesionGO:00071553290.012
positive regulation of cell motilityGO:20001471160.012
cell fate commitmentGO:00451652100.012
mrna metabolic processGO:0016071840.012
respiratory tube developmentGO:00303231670.011
stress activated protein kinase signaling cascadeGO:0031098810.011
plasma membrane organizationGO:0007009900.011
carbohydrate derivative biosynthetic processGO:19011371830.011
response to peptideGO:19016521360.011
protein modification by small protein removalGO:0070646210.011
cerebral cortex developmentGO:0021987860.011
blood vessel morphogenesisGO:00485142850.011
meiotic nuclear divisionGO:00071261150.011
response to temperature stimulusGO:0009266550.011
neuron apoptotic processGO:00514021420.011
response to extracellular stimulusGO:00099911270.011
wnt signaling pathwayGO:00160551880.011
purine ribonucleoside triphosphate metabolic processGO:00092052200.011
Human Fly
developmental cell growthGO:0048588840.011
Zebrafish
cell cycle g1 s phase transitionGO:0044843570.011
cation transmembrane transportGO:00986552660.011
organonitrogen compound biosynthetic processGO:19015661920.011
meiotic cell cycleGO:00513211220.011
divalent inorganic cation transportGO:00725111780.011
regulation of cell projection organizationGO:00313442060.011
Zebrafish Fly
developmental maturationGO:00217001930.011
regulation of purine nucleotide metabolic processGO:19005421690.011
cellular response to external stimulusGO:0071496880.011
regulation of intracellular protein transportGO:0033157820.011
regulation of histone modificationGO:0031056560.011
regulation of purine nucleotide catabolic processGO:00331211220.011
epithelium migrationGO:0090132630.011
bmp signaling pathwayGO:0030509930.011
purine containing compound catabolic processGO:00725232130.011
Human Fly
innate immune responseGO:00450871570.011
regulation of cellular protein catabolic processGO:1903362610.011
positive regulation of neuron differentiationGO:00456661410.011
Zebrafish Fly
cellular response to nutrient levelsGO:0031669640.011
gland developmentGO:00487323300.011
regulation of lymphocyte differentiationGO:00456191070.010
neuronal action potentialGO:0019228540.010
hyperosmotic responseGO:000697240.010
regulation of innate immune responseGO:0045088910.010
regulation of chromatin modificationGO:1903308570.010
oocyte constructionGO:000730820.010
leukocyte mediated immunityGO:00024431740.010
gonad developmentGO:00084061410.010
positive regulation of mapk cascadeGO:00434101700.010
regulation of dna recombinationGO:0000018340.010
guanosine containing compound metabolic processGO:19010681440.010
negative regulation of neuron deathGO:1901215980.010
positive regulation of protein transportGO:0051222930.010
regulation of neuron differentiationGO:00456642810.010
Zebrafish Fly
regulation of lymphocyte mediated immunityGO:0002706840.010
regulation of muscle tissue developmentGO:1901861970.010
regulation of epithelial cell migrationGO:0010632350.010
cellular chemical homeostasisGO:00550822150.010
positive regulation of innate immune responseGO:0045089800.010

Spast disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.075
Human
nervous system diseaseDOID:86300.075
Human
organ system cancerDOID:005068600.018
disease of cellular proliferationDOID:1456600.018
cancerDOID:16200.018
neurodegenerative diseaseDOID:128900.010
central nervous system diseaseDOID:33100.010
Human