Mus musculus

553 known processes

Psen1

presenilin 1

(Aliases: PS-1,PS1,S182,Ad3h)

Psen1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
somite specificationGO:000175741.000
lateral inhibitionGO:004633111.000
Fly
negative regulation of blood vessel endothelial cell migrationGO:004353731.000
regulation of somitogenesisGO:001480761.000
notch signaling pathwayGO:0007219711.000
notch receptor processingGO:000722041.000
regulation of epidermal growth factor activated receptor activityGO:000717671.000
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161881.000
cardiac right atrium morphogenesisGO:000321330.999
cell migration involved in endocardial cushion formationGO:000327330.999
somitogenesisGO:0001756690.999
negative regulation of neuron differentiationGO:00456651010.999
embryonic organ morphogenesisGO:00485622760.999
neuroblast fate determinationGO:000740010.999
endoplasmic reticulum calcium ion homeostasisGO:0032469110.999
growth involved in heart morphogenesisGO:000324140.999
proteolysis involved in cellular protein catabolic processGO:00516031470.999
protein processingGO:00164851630.998
compartment pattern specificationGO:000738640.998
arterial endothelial cell differentiationGO:006084250.998
positive regulation of transcription from rna polymerase ii promoter in response to stressGO:003600330.998
formation of radial glial scaffoldsGO:002194340.997
neural tube developmentGO:00219151600.997
segment specificationGO:0007379150.996
forebrain developmentGO:00309003020.996
cell cell signaling involved in cell fate commitmentGO:0045168350.996
Fly
axonogenesisGO:00074092740.996
glycoprotein biosynthetic processGO:0009101890.995
neural tube patterningGO:0021532430.995
cell adhesionGO:00071553290.995
Human Fly
ubiquitin dependent protein catabolic processGO:00065111290.994
anagenGO:0042640130.994
epithelial tube morphogenesisGO:00605623030.994
activation of mapkk activityGO:0000186150.994
positive regulation of map kinase activityGO:0043406840.994
negative regulation of cell developmentGO:00107211690.994
canonical wnt signaling pathway involved in heart developmentGO:006131630.993
regulation of cardioblast differentiationGO:005189030.993
regionalizationGO:00030023370.992
photoreceptor cell morphogenesisGO:000859430.992
skeletal system developmentGO:00015013560.992
negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:1902042110.991
Mouse
ventricular trabecula myocardium morphogenesisGO:0003222110.991
modification dependent macromolecule catabolic processGO:00436321330.991
positive regulation of transcription of notch receptor targetGO:000722140.991
atrioventricular node developmentGO:000316230.990
negative regulation of photoreceptor cell differentiationGO:004653340.989
glycoprotein metabolic processGO:00091001160.989
blood vessel endothelial cell differentiationGO:006083760.988
positive regulation of apoptotic signaling pathwayGO:2001235950.987
Mouse
membrane protein proteolysisGO:0033619100.987
Human
endothelial tube morphogenesisGO:006115420.986
regulation of pro b cell differentiationGO:200097350.985
copper ion homeostasisGO:005507090.984
cell fate determination involved in pattern specificationGO:006058210.983
glomerular mesangial cell differentiationGO:007200830.983
modification dependent protein catabolic processGO:00199411330.982
telencephalon cell migrationGO:0022029550.982
myeloid dendritic cell differentiationGO:0043011160.982
neuroblast division in subventricular zoneGO:002184920.980
columnar cuboidal epithelial cell differentiationGO:0002065820.979
Zebrafish
regulation of resting membrane potentialGO:006007530.979
regulation of protein serine threonine kinase activityGO:00719001570.979
positive regulation of proteolysis involved in cellular protein catabolic processGO:1903052310.979
regulation of cell migration involved in sprouting angiogenesisGO:009004940.978
glycosylationGO:0070085620.977
positive regulation of notch signaling pathwayGO:0045747180.977
regulation of cellular amino acid metabolic processGO:000652150.977
glial cell fate determinationGO:000740330.977
blood vessel lumenizationGO:007255420.976
neuroblast differentiationGO:001401620.974
pharynx developmentGO:006046510.974
glomerular capillary formationGO:007210460.974
ciliary body morphogenesisGO:006107330.971
embryonic heart tube developmentGO:0035050650.969
regulation of cardiac cell fate specificationGO:200004310.966
digestive tract developmentGO:00485651900.966
epithelial cell proliferationGO:00506731740.965
negative regulation of protein maturationGO:1903318790.964
establishment of synaptic vesicle localizationGO:0097480570.964
morphogenesis of an endotheliumGO:000315920.963
regulation of neuron differentiationGO:00456642810.962
somite developmentGO:0061053810.962
apoptotic process involved in embryonic digit morphogenesisGO:190226330.962
notch signaling involved in heart developmentGO:006131450.962
dorsal ventral neural tube patterningGO:0021904280.962
negative regulation of protein phosphorylationGO:00019331260.961
regulation of map kinase activityGO:00434051200.960
peptidyl tyrosine modificationGO:00182121450.960
positive regulation of transcription from rna polymerase ii promoter in response to hypoxiaGO:006141910.958
regulation of blood vessel endothelial cell migrationGO:0043535120.957
glomerular mesangial cell developmentGO:007214430.955
negative regulation of epidermis developmentGO:004568390.954
telencephalon developmentGO:00215371860.952
negative regulation of glial cell proliferationGO:006025340.952
response to symbiontGO:000960820.952
carbohydrate derivative biosynthetic processGO:19011371830.951
appendage developmentGO:00487361660.951
autophagyGO:0006914450.951
inner ear receptor cell differentiationGO:0060113610.949
cardiac endothelial cell differentiationGO:000334840.949
sprouting angiogenesisGO:0002040260.947
kidney developmentGO:00018222130.947
embryonic heart tube morphogenesisGO:0003143510.942
synaptic vesicle transportGO:0048489570.941
negative regulation of endothelial cell migrationGO:001059640.940
cellular ketone metabolic processGO:0042180840.937
brain morphogenesisGO:0048854320.937
negative regulation of neuron projection developmentGO:0010977500.934
cellular amide metabolic processGO:0043603580.932
determination of heart left right asymmetryGO:0061371480.931
regulation of apoptotic signaling pathwayGO:20012331970.931
pericardium morphogenesisGO:000334450.929
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus developmentGO:006052840.928
positive regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032436230.927
regulation of cellular amine metabolic processGO:0033238200.925
glial cell migrationGO:000834770.925
cell fate commitmentGO:00451652100.924
negative regulation of peptidyl tyrosine phosphorylationGO:0050732170.923
negative regulation of epidermal cell differentiationGO:004560570.923
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.923
organic hydroxy compound transportGO:0015850930.923
regulation of astrocyte differentiationGO:0048710200.923
germ cell developmentGO:00072811850.921
regulation of bindingGO:00510981110.920
response to starvationGO:0042594650.919
sensory organ boundary specificationGO:000805210.918
regulation of notch signaling pathwayGO:0008593350.916
Fly
cell fate commitment involved in pattern specificationGO:0060581140.916
negative regulation of cell projection organizationGO:0031345560.915
appendage morphogenesisGO:00351071490.915
myeloid dendritic cell activationGO:0001773250.914
negative regulation of anoikisGO:200081120.913
mesenchyme developmentGO:00604851520.912
embryonic appendage morphogenesisGO:00351131260.910
dendrite developmentGO:00163581150.909
mesangial cell differentiationGO:007200740.909
embryonic skeletal system developmentGO:00487061200.907
negative regulation of cell morphogenesis involved in differentiationGO:0010771480.905
protein glycosylationGO:0006486550.904
protein maturationGO:00516041760.904
dendritic cell differentiationGO:0097028260.904
regulation of cell migrationGO:00303342190.903
extrinsic apoptotic signaling pathwayGO:00971911260.902
Mouse
heart field specificationGO:000312860.902
positive regulation of protein kinase activityGO:00458601440.901
neuroblast fate commitmentGO:001401710.899
positive regulation of keratinocyte differentiationGO:004561830.898
blood vessel endothelial cell migrationGO:0043534230.896
venous blood vessel morphogenesisGO:004884570.896
choline transportGO:001587130.895
negative regulation of auditory receptor cell differentiationGO:004560820.895
protein catabolic processGO:00301632210.895
positive regulation of mitotic cell cycle phase transitionGO:1901992170.894
extrinsic apoptotic signaling pathway via death domain receptorsGO:0008625340.893
Mouse
negative regulation of kinase activityGO:0033673810.887
negative regulation of glial cell differentiationGO:0045686210.882
regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiationGO:000325660.882
hair follicle morphogenesisGO:0031069290.880
negative regulation of protein processingGO:0010955790.878
regulation of chemotaxisGO:0050920530.876
regulation of transferase activityGO:00513382630.875
determination of left right symmetryGO:0007368800.875
hair follicle developmentGO:0001942850.874
positive regulation of mapk cascadeGO:00434101700.871
regulation of proteolysisGO:00301621640.870
i kappab phosphorylationGO:000725260.869
regulation of cardiac muscle tissue developmentGO:0055024310.864
macromolecule glycosylationGO:0043413550.863
positive regulation of osteoclast differentiationGO:0045672150.863
dorsal aorta morphogenesisGO:003591250.857
cardiac right ventricle formationGO:000321930.857
pigment cell differentiationGO:0050931270.856
Zebrafish
epithelial to mesenchymal transition involved in endocardial cushion formationGO:0003198100.852
negative regulation of apoptotic signaling pathwayGO:20012341040.851
molting cycleGO:0042303900.847
axis elongation involved in somitogenesisGO:009024540.844
morphogenesis of a branching epitheliumGO:00611381930.844
glomerulus vasculature morphogenesisGO:007210360.843
establishment of vesicle localizationGO:0051650810.840
placenta blood vessel developmentGO:0060674310.839
cellular amino acid metabolic processGO:00065201030.836
planar cell polarity pathway involved in cardiac muscle tissue morphogenesisGO:006135020.836
beta amyloid metabolic processGO:0050435140.835
membrane protein ectodomain proteolysisGO:000650970.835
Human
mechanoreceptor differentiationGO:0042490670.834
organelle localizationGO:00516401790.831
cytoskeleton dependent intracellular transportGO:0030705500.830
lung inductionGO:006049230.827
negative regulation of planar cell polarity pathway involved in pericardium morphogenesisGO:200016610.826
respiratory system developmentGO:00605411900.824
Mouse
stem cell maintenanceGO:00198271300.818
positive regulation of cell morphogenesis involved in differentiationGO:0010770720.817
learning or memoryGO:00076111480.817
negative regulation of calcium ion dependent exocytosisGO:004595530.814
negative regulation of mechanoreceptor differentiationGO:004563230.812
melanocyte differentiationGO:0030318250.812
Zebrafish
hair cycleGO:0042633900.811
cardiac cell fate specificationGO:006091220.809
positive regulation of cell cycle g1 s phase transitionGO:190280890.808
glomerular epithelial cell developmentGO:007231060.808
regulation of cell morphogenesis involved in differentiationGO:00107691510.807
renal system developmentGO:00720012250.807
regulation of extracellular matrix assemblyGO:190120120.807
muscle tissue developmentGO:00605373080.805
urogenital system developmentGO:00016552610.804
regulation of synaptic plasticityGO:0048167870.802
positive regulation of extrinsic apoptotic signaling pathwayGO:2001238340.802
Mouse
smooth endoplasmic reticulum calcium ion homeostasisGO:005156320.802
gastrulationGO:00073691160.799
skin morphogenesisGO:0043589380.792
macromolecule catabolic processGO:00090572810.792
cardiac muscle tissue developmentGO:00487381300.791
regulation of endothelial cell chemotaxisGO:200102610.790
positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:1902043130.788
Mouse
regulation of dna templated transcription in response to stressGO:004362090.788
regulation of planar cell polarity pathway involved in ventricular septum morphogenesisGO:200014810.787
negative regulation of endothelial cell differentiationGO:004560220.786
renal tubule developmentGO:0061326870.785
positive regulation of kinase activityGO:00336741550.784
glomerular visceral epithelial cell developmentGO:007201560.782
pyramidal neuron migrationGO:002185210.780
interleukin 4 secretionGO:007260250.772
regulation of gliogenesisGO:0014013500.770
carbohydrate metabolic processGO:00059752300.768
epidermis morphogenesisGO:0048730330.767
cardiac septum morphogenesisGO:0060411460.764
regulation of planar cell polarity pathway involved in outflow tract morphogenesisGO:200016310.763
cardiac muscle tissue morphogenesisGO:0055008440.763
cerebral cortex developmentGO:0021987860.762
canonical wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferationGO:006132420.759
regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:2000058140.757
cell type specific apoptotic processGO:00972852680.756
regulation of kinase activityGO:00435492490.756
regulation of endodermal cell fate specificationGO:004266320.753
cardiac left ventricle morphogenesisGO:000321490.747
vascular smooth muscle cell differentiationGO:0035886110.744
cardiac vascular smooth muscle cell developmentGO:006094830.742
negative regulation of cell proliferationGO:00082852960.738
positive regulation of cell cycleGO:0045787920.734
pulmonary valve morphogenesisGO:000318450.733
hindbrain radial glia guided cell migrationGO:0021932120.733
l amino acid transportGO:0015807320.732
negative regulation of proteolysisGO:0045861740.730
hair cell differentiationGO:0035315400.729
leukocyte differentiationGO:00025213420.729
morphogenesis of embryonic epitheliumGO:00163311590.728
regulation of proteolysis involved in cellular protein catabolic processGO:1903050560.727
peptidyl amino acid modificationGO:00181933360.726
amine metabolic processGO:0009308450.726
pallium developmentGO:00215431200.721
stem cell differentiationGO:00488632680.721
cerebral cortex neuron differentiationGO:0021895190.721
l glutamate transportGO:0015813160.718
endodermal cell fate commitmentGO:0001711120.717
wnt signaling pathway involved in somitogenesisGO:009024440.715
striated muscle contractionGO:0006941450.713
Mouse
regulation of epithelial cell proliferation involved in prostate gland developmentGO:0060768100.712
regulation of protein tyrosine kinase activityGO:0061097170.712
regulation of transcription from rna polymerase ii promoter in response to stressGO:004361880.707
negative regulation of molecular functionGO:00440922580.704
positive regulation of protein phosphorylationGO:00019342420.702
humoral immune responseGO:0006959570.701
epidermis developmentGO:00085441870.701
epithelial cell differentiation involved in prostate gland developmentGO:0060742130.695
cell surface receptor signaling pathway involved in heart developmentGO:0061311150.693
mesoderm developmentGO:00074981000.692
apoptotic process involved in developmentGO:1902742280.691
heart morphogenesisGO:00030071780.689
limb morphogenesisGO:00351081490.688
branching morphogenesis of an epithelial tubeGO:00487541590.677
skeletal system morphogenesisGO:00487052030.675
embryonic limb morphogenesisGO:00303261260.675
negative regulation of cellular protein catabolic processGO:1903363220.672
formation of organ boundaryGO:001016010.671
protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:0042787250.670
regulation of protein kinase activityGO:00458592320.669
peptidyl tyrosine phosphorylationGO:00181081430.669
negative regulation of phosphorylationGO:00423261660.667
positive regulation of myeloid leukocyte differentiationGO:0002763260.665
cell chemotaxisGO:0060326810.663
endodermal cell fate specificationGO:000171440.663
negative regulation of bmp signaling pathwayGO:0030514350.659
neuron apoptotic processGO:00514021420.652
regulation of mitotic cell cycle phase transitionGO:1901990730.650
negative regulation of astrocyte differentiationGO:0048712100.647
positive regulation of transcription by glucoseGO:004601630.645
coronary vein morphogenesisGO:000316920.641
cell adhesion mediated by integrinGO:0033627180.641
cardiac chamber developmentGO:00032051080.639
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434400.637
digestive tract morphogenesisGO:00485461470.636
myeloid leukocyte differentiationGO:00025731190.635
cell fate specificationGO:0001708720.634
carbon catabolite repression of transcription from rna polymerase ii promoterGO:000043710.633
wnt signaling pathwayGO:00160551880.631
Zebrafish
ameboidal type cell migrationGO:00016671280.630
gland developmentGO:00487323300.628
cognitionGO:00508901490.628
glomerulus morphogenesisGO:0072102100.627
positive regulation of protein modification processGO:00314012990.626
regulation of protein complex assemblyGO:0043254830.626
Mouse
dorsal aorta developmentGO:003590760.622
regulation of receptor recyclingGO:000191980.620
negative regulation of hematopoietic progenitor cell differentiationGO:190153340.620
photoreceptor cell differentiationGO:0046530520.619
cell cell adhesion via plasma membrane adhesion moleculesGO:0098742400.618
establishment of organelle localizationGO:00516561220.616
positive regulation of protein serine threonine kinase activityGO:00719021060.616
heart trabecula morphogenesisGO:0061384260.616
er associated ubiquitin dependent protein catabolic processGO:0030433100.615
positive regulation of proteolysisGO:0045862850.613
cellular homeostasisGO:00197252400.613
positive regulation of bmp signaling pathwayGO:0030513230.609
mitotic cell cycle processGO:19030471590.607
cellular chemical homeostasisGO:00550822150.607
mesangial cell developmentGO:007214340.606
regulation of apoptotic process involved in outflow tract morphogenesisGO:190225620.605
negative regulation of nervous system developmentGO:00519611560.604
positive regulation of astrocyte differentiationGO:004871180.602
germ line stem cell divisionGO:004207820.597
germ line stem cell maintenanceGO:003071860.592
pole plasm assemblyGO:000731520.590
regulation of epidermis developmentGO:0045682330.587
meiotic cell cycleGO:00513211220.587
negative regulation of planar cell polarity pathway involved in heart morphogenesisGO:200016010.580
regulation of mitotic cell cycleGO:00073461260.579
regulation of anoikisGO:200020920.575
regulation of epidermal cell differentiationGO:0045604210.572
negative regulation of protein modification processGO:00314001630.570
digestive system developmentGO:00551232000.569
blood vessel morphogenesisGO:00485142850.568
protein modification by small protein conjugation or removalGO:00706472070.568
ossificationGO:00015032160.568
regulation of cardiac muscle cell differentiationGO:200072590.568
smoothened signaling pathwayGO:00072241050.567
positive regulation of cell cycle phase transitionGO:1901989170.566
memoryGO:0007613580.562
photoreceptor cell developmentGO:0042461400.562
negative regulation of cellular protein metabolic processGO:00322692470.562
hair cycle phaseGO:0044851160.562
regulation of striated muscle cell differentiationGO:0051153810.562
adult behaviorGO:00305341350.561
regulation of auditory receptor cell differentiationGO:004560740.560
limb developmentGO:00601731660.558
neuron projection guidanceGO:00974851410.555
left right pattern formationGO:0060972230.554
synaptic transmissionGO:00072683290.551
negative regulation of striated muscle cell differentiationGO:0051154140.547
segmentationGO:0035282930.544
forebrain cell migrationGO:0021885580.543
insulin secretion involved in cellular response to glucose stimulusGO:0035773360.540
endoderm developmentGO:0007492450.540
cardiac conduction system developmentGO:0003161120.538
regulation of ligase activityGO:0051340100.536
regulation of endodermal cell differentiationGO:190322420.536
auditory receptor cell differentiationGO:0042491370.535
carbon catabolite activation of transcription from rna polymerase ii promoterGO:000043640.533
endocytosisGO:00068971680.533
embryonic skeletal system morphogenesisGO:0048704910.532
heparan sulfate proteoglycan metabolic processGO:0030201100.532
neuron migrationGO:00017641220.531
mesenchymal cell differentiationGO:00487621070.530
positive regulation of cardiac muscle cell differentiationGO:200072760.529
regulation of cilium assemblyGO:190201770.529
regulation of epidermal growth factor receptor signaling pathwayGO:0042058130.526
negative regulation of inner ear receptor cell differentiationGO:200098130.525
spermatogenesisGO:00072832840.524
positive regulation of g1 s transition of mitotic cell cycleGO:190008790.523
cellular protein catabolic processGO:00442571550.523
regulation of protein bindingGO:0043393600.522
wnt signaling pathway involved in forebrain neuroblast divisionGO:002187420.521
metanephros developmentGO:0001656790.520
proximal tubule developmentGO:007201450.520
heart formationGO:0060914160.519
negative regulation of epithelial cell migrationGO:001063390.517
myeloid cell differentiationGO:00300992330.517
regulation of glial cell differentiationGO:0045685410.513
compound eye developmentGO:004874910.512
negative regulation of fat cell differentiationGO:0045599360.510
lung developmentGO:00303241640.508
Mouse
inner ear receptor cell fate commitmentGO:006012060.508
negative regulation of pro b cell differentiationGO:200097410.508
forebrain radial glial cell differentiationGO:002186140.507
canonical wnt signaling pathway involved in regulation of cell proliferationGO:004434030.506
regulation of cellular catabolic processGO:00313292420.506
positive regulation of mitotic cell cycleGO:0045931410.503
epithelial cell differentiation involved in kidney developmentGO:0035850230.502
regulation of hematopoietic progenitor cell differentiationGO:1901532180.500
negative regulation of protein tyrosine kinase activityGO:006109930.499
morphogenesis of a polarized epitheliumGO:0001738370.499
nephron tubule morphogenesisGO:0072078680.496
receptor recyclingGO:0001881110.495
long term memoryGO:0007616150.492
glomerular visceral epithelial cell differentiationGO:0072112100.491
regulation of receptor activityGO:0010469410.489
negative regulation of dendritic spine morphogenesisGO:006100230.487
regulation of cell cycle phase transitionGO:1901987770.485
glomerular epithelial cell differentiationGO:0072311100.484
morphogenesis of an epithelial sheetGO:0002011270.484
negative regulation of cellular catabolic processGO:0031330470.483
mitotic cell cycleGO:00002781950.483
regulation of cellular component biogenesisGO:00440871810.481
Mouse
jak stat cascadeGO:0007259420.480
developmental programmed cell deathGO:0010623410.474
regulation of osteoclast differentiationGO:0045670360.473
regulation of lipid metabolic processGO:00192161180.472
sensory organ morphogenesisGO:00905962420.471
organelle assemblyGO:00709251770.470
cardiac muscle cell differentiationGO:0055007690.469
positive regulation of mitotic sister chromatid separationGO:190197020.469
glial cell apoptotic processGO:003434930.469
neuron deathGO:00709971540.468
microtubule based processGO:00070172360.467
small gtpase mediated signal transductionGO:0007264970.464
regulation of establishment of planar polarityGO:0090175280.462
cellular amine metabolic processGO:0044106440.462
regulation of cellular ketone metabolic processGO:0010565660.460
adult locomotory behaviorGO:0008344910.458
nephric duct formationGO:007217940.455
establishment of tissue polarityGO:0007164280.455
neural tube formationGO:00018411080.453
peripheral nervous system neuron axonogenesisGO:004893630.449
cardiac atrium developmentGO:0003230240.449
nodal signaling pathway involved in determination of left right asymmetryGO:003810720.448
carbon catabolite regulation of transcription from rna polymerase ii promoterGO:000042940.445
regulation of hydrolase activityGO:00513362460.444
carbon catabolite regulation of transcriptionGO:004599040.442
regulation of transcription from rna polymerase ii promoter in response to hypoxiaGO:006141820.440
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101610.439
regulation of epithelial to mesenchymal transitionGO:0010717220.439
negative regulation of dendrite developmentGO:200017190.438
response to lithium ionGO:0010226100.437
positive regulation of cell fate commitmentGO:001045580.436
signal transduction in absence of ligandGO:0038034550.435
regulation of protein maturationGO:1903317960.434
bone remodelingGO:0046849530.432
multi organism reproductive behaviorGO:0044705290.431
biological phaseGO:0044848200.430
hypermethylation of cpg islandGO:004402730.426
carbon catabolite activation of transcriptionGO:004599140.425
regulation of microtubule based processGO:0032886520.425
cellular response to starvationGO:0009267570.422
erbb signaling pathwayGO:0038127320.421
secondary heart field specificationGO:000313960.418
regulation of stem cell differentiationGO:2000736500.417
negative regulation of cardiac muscle tissue developmentGO:005502680.417
planar cell polarity pathway involved in pericardium morphogenesisGO:006135420.416
endocardial cushion cell differentiationGO:006144310.416
cerebral cortex cell migrationGO:0021795440.415
kidney morphogenesisGO:0060993830.414
embryonic viscerocranium morphogenesisGO:004870380.412
positive regulation of cell developmentGO:00107202370.412
microtubule based movementGO:0007018840.411
hippocampus developmentGO:0021766520.409
positive regulation of creb transcription factor activityGO:003279340.409
cerebral cortex radially oriented cell migrationGO:0021799310.407
clara cell differentiationGO:006048640.405
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesisGO:200014910.405
female sex differentiationGO:0046660840.404
glomerulus vasculature developmentGO:0072012140.401
positive regulation of glial cell differentiationGO:0045687210.395
midbrain hindbrain boundary morphogenesisGO:002155540.394
regulation of cell motilityGO:20001452360.394
meiotic nuclear divisionGO:00071261150.393
osteoclast differentiationGO:0030316620.390
exocytosisGO:00068871210.390
prostate gland morphogenesisGO:0060512320.388
developmental maturationGO:00217001930.388
regulation of mesodermal cell fate specificationGO:004266150.387
positive regulation of cellular protein catabolic processGO:1903364340.386
positive regulation of epithelial to mesenchymal transitionGO:0010718130.386
actin cytoskeleton organizationGO:00300362200.385
developmental growth involved in morphogenesisGO:00605601380.385
negative regulation of protein modification by small protein conjugation or removalGO:1903321200.385
positive regulation of transcription from rna polymerase ii promoter by glucoseGO:000043230.385
mapk cascadeGO:00001652810.383
regulation of peptidyl tyrosine phosphorylationGO:0050730930.382
kidney interstitial fibroblast differentiationGO:007207150.380
odontogenesisGO:0042476780.380
negative regulation of ubiquitin protein transferase activityGO:005144430.378

Psen1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
central nervous system diseaseDOID:33100.981
Human
disease of anatomical entityDOID:700.981
Human
nervous system diseaseDOID:86300.981
Human
heart diseaseDOID:11400.967
Human
cardiovascular system diseaseDOID:128700.967
Human
dementiaDOID:130700.958
Human
alzheimer s diseaseDOID:1065200.958
Human
disease of mental healthDOID:15000.958
Human
tauopathyDOID:68000.958
Human
neurodegenerative diseaseDOID:128900.958
Human
cognitive disorderDOID:156100.958
Human
integumentary system diseaseDOID:1600.954
Human
muscular diseaseDOID:008000000.918
Human
musculoskeletal system diseaseDOID:1700.918
Human
muscle tissue diseaseDOID:6600.918
Human
disease of cellular proliferationDOID:1456600.589
skin diseaseDOID:3700.548
Human
gastrointestinal system diseaseDOID:7700.419