IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Appl2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

(Aliases: Dip3b)

Ensembl: ENSMUSG00000020263
Entrez: 216190
UniProtKB: Q3TVI6
UniProtKB: Q8K3G9

Process Predictions
Disease Predictions

Appl2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
cellular amino acid metabolic process	GO:0006520	103	0.091
cellular ketone metabolic process	GO:0042180	84	0.070
regulation of cellular amino acid metabolic process	GO:0006521	5	0.067
cellular amine metabolic process	GO:0044106	44	0.066
negative regulation of cellular protein metabolic process	GO:0032269	247	0.064
histone lysine methylation	GO:0034968	50	0.054
peptidyl amino acid modification	GO:0018193	336	0.051
nucleobase containing small molecule metabolic process	GO:0055086	352	0.051
response to peptide hormone	GO:0043434	127	0.050
actin cytoskeleton organization	GO:0030036	220	0.049
regulation of cellular ketone metabolic process	GO:0010565	66	0.047
amine metabolic process	GO:0009308	45	0.045
organelle localization	GO:0051640	179	0.043
regionalization	GO:0003002	337	0.042
negative regulation of cellular component organization	GO:0051129	194	0.042
response to organonitrogen compound	GO:0010243	246	0.041
regulation of apoptotic signaling pathway	GO:2001233	197	0.040
cellular nitrogen compound catabolic process	GO:0044270	280	0.038
carbohydrate metabolic process	GO:0005975	230	0.038
reactive oxygen species metabolic process	GO:0072593	84	0.038
dna metabolic process	GO:0006259	303	0.038
urogenital system development	GO:0001655	261	0.038
dephosphorylation	GO:0016311	129	0.038
cation transport	GO:0006812	399	0.037
primary neural tube formation	GO:0014020	95	0.037
posttranscriptional regulation of gene expression	GO:0010608	155	0.037
embryonic epithelial tube formation	GO:0001838	130	0.037
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.036
cell type specific apoptotic process	GO:0097285	268	0.036
stem cell development	GO:0048864	219	0.035
negative regulation of protein metabolic process	GO:0051248	282	0.035
cellular response to cytokine stimulus	GO:0071345	189	0.034
cellular response to hormone stimulus	GO:0032870	150	0.032
small gtpase mediated signal transduction	GO:0007264	97	0.032
cellular carbohydrate metabolic process	GO:0044262	119	0.032
cellular lipid metabolic process	GO:0044255	323	0.032
nucleotide metabolic process	GO:0009117	332	0.032
locomotory behavior	GO:0007626	195	0.032
synaptic transmission	GO:0007268	329	0.032
cellular macromolecule catabolic process	GO:0044265	206	0.031
g protein coupled receptor signaling pathway	GO:0007186	243	0.031
cellular response to organonitrogen compound	GO:0071417	145	0.031
establishment of organelle localization	GO:0051656	122	0.030
regulation of organelle organization	GO:0033043	289	0.030
cellular protein complex assembly	GO:0043623	116	0.030
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.030
regulation of cellular amine metabolic process	GO:0033238	20	0.030
purine nucleoside metabolic process	GO:0042278	241	0.030
positive regulation of protein modification process	GO:0031401	299	0.029
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.029
positive regulation of apoptotic process	GO:0043065	217	0.029
positive regulation of cellular amine metabolic process	GO:0033240	5	0.029
regulation of hydrolase activity	GO:0051336	246	0.028
organophosphate catabolic process	GO:0046434	232	0.028
cellular response to dna damage stimulus	GO:0006974	207	0.028
guanosine containing compound catabolic process	GO:1901069	144	0.027
negative regulation of nervous system development	GO:0051961	156	0.027
chromatin organization	GO:0006325	206	0.027
vesicle localization	GO:0051648	86	0.027
homeostasis of number of cells	GO:0048872	210	0.027
cytokine production	GO:0001816	319	0.026
organonitrogen compound catabolic process	GO:1901565	264	0.026
regulation of intracellular transport	GO:0032386	159	0.026
male gamete generation	GO:0048232	285	0.026
glucose homeostasis	GO:0042593	128	0.026
regulation of cell activation	GO:0050865	289	0.025
maintenance of location	GO:0051235	89	0.025
chromatin modification	GO:0016568	187	0.025
ribonucleoside metabolic process	GO:0009119	245	0.025
phospholipid biosynthetic process	GO:0008654	36	0.025
hexose metabolic process	GO:0019318	98	0.025
regulation of protein localization	GO:0032880	231	0.025
compound eye development	GO:0048749	1	0.024
ribonucleoside catabolic process	GO:0042454	206	0.024
epithelial tube morphogenesis	GO:0060562	303	0.024
regulation of transferase activity	GO:0051338	263	0.024
heterocycle catabolic process	GO:0046700	280	0.024
response to light stimulus	GO:0009416	135	0.023
positive regulation of gtp catabolic process	GO:0033126	85	0.023
renal system development	GO:0072001	225	0.023
negative regulation of protein modification process	GO:0031400	163	0.023
regulation of membrane potential	GO:0042391	192	0.022
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.022
regulation of lymphocyte activation	GO:0051249	240	0.022
cellular response to organic cyclic compound	GO:0071407	87	0.022
protein modification by small protein conjugation	GO:0032446	187	0.022
positive regulation of cell death	GO:0010942	224	0.022
ras protein signal transduction	GO:0007265	77	0.022
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.021
neural tube formation	GO:0001841	108	0.021
purine nucleotide metabolic process	GO:0006163	302	0.021
peptidyl tyrosine modification	GO:0018212	145	0.021
macromolecule catabolic process	GO:0009057	281	0.021
transmembrane transport	GO:0055085	412	0.021
regulation of cellular component biogenesis	GO:0044087	181	0.020
ribonucleotide metabolic process	GO:0009259	291	0.020
negative regulation of cell proliferation	GO:0008285	296	0.020
regulation of homeostatic process	GO:0032844	182	0.020
organic cyclic compound catabolic process	GO:1901361	295	0.020
aromatic compound catabolic process	GO:0019439	286	0.020
muscle cell differentiation	GO:0042692	261	0.020
microtubule based process	GO:0007017	236	0.020
rna processing	GO:0006396	105	0.020
rhythmic process	GO:0048511	174	0.020
lipid biosynthetic process	GO:0008610	179	0.020
positive regulation of organelle organization	GO:0010638	128	0.019
purine containing compound metabolic process	GO:0072521	311	0.019
protein modification by small protein conjugation or removal	GO:0070647	207	0.019
cytokine mediated signaling pathway	GO:0019221	115	0.019
carbohydrate derivative biosynthetic process	GO:1901137	183	0.019
embryonic organ morphogenesis	GO:0048562	276	0.019
inorganic ion transmembrane transport	GO:0098660	234	0.019
purine nucleoside catabolic process	GO:0006152	205	0.019
divalent inorganic cation transport	GO:0072511	178	0.019
protein catabolic process	GO:0030163	221	0.019
positive regulation of protein phosphorylation	GO:0001934	242	0.019
positive regulation of programmed cell death	GO:0043068	218	0.019
positive regulation of nervous system development	GO:0051962	221	0.019
nucleoside phosphate metabolic process	GO:0006753	338	0.019
membrane organization	GO:0061024	245	0.018
gland development	GO:0048732	330	0.018
generation of precursor metabolites and energy	GO:0006091	103	0.018
apoptotic signaling pathway	GO:0097190	306	0.018
cellular response to lipid	GO:0071396	145	0.018
mitotic cell cycle	GO:0000278	195	0.018
digestive system development	GO:0055123	200	0.018
regulation of cytokine production	GO:0001817	266	0.018
methylation	GO:0032259	134	0.018
peptidyl tyrosine phosphorylation	GO:0018108	143	0.018
negative regulation of cell development	GO:0010721	169	0.018
dna repair	GO:0006281	107	0.018
glycosyl compound catabolic process	GO:1901658	206	0.018
leukocyte differentiation	GO:0002521	342	0.018
regulation of cellular catabolic process	GO:0031329	242	0.018
nucleotide catabolic process	GO:0009166	217	0.018
myeloid cell differentiation	GO:0030099	233	0.018
positive regulation of protein catabolic process	GO:0045732	60	0.017
cytoplasmic transport	GO:0016482	234	0.017
response to inorganic substance	GO:0010035	96	0.017
response to oxygen levels	GO:0070482	62	0.017
negative regulation of organelle organization	GO:0010639	90	0.017
response to organic cyclic compound	GO:0014070	198	0.017
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.017
tube formation	GO:0035148	140	0.017
glycerophospholipid metabolic process	GO:0006650	71	0.017
regulation of cell cycle	GO:0051726	281	0.017
regulation of anatomical structure size	GO:0090066	178	0.017
spermatid differentiation	GO:0048515	115	0.017
nucleoside phosphate catabolic process	GO:1901292	222	0.017
organophosphate biosynthetic process	GO:0090407	122	0.017
establishment of vesicle localization	GO:0051650	81	0.017
regulation of protein complex assembly	GO:0043254	83	0.017
stem cell differentiation	GO:0048863	268	0.017
ribose phosphate metabolic process	GO:0019693	291	0.017
inorganic cation transmembrane transport	GO:0098662	207	0.017
exocytosis	GO:0006887	121	0.017
negative regulation of intracellular signal transduction	GO:1902532	167	0.017
regulation of protein serine threonine kinase activity	GO:0071900	157	0.017
ribonucleotide catabolic process	GO:0009261	208	0.017
protein targeting	GO:0006605	143	0.016
cation transmembrane transport	GO:0098655	266	0.016
circulatory system process	GO:0003013	197	0.016
actin filament organization	GO:0007015	113	0.016
ion transmembrane transport	GO:0034220	361	0.016
purine ribonucleotide metabolic process	GO:0009150	290	0.016
carbohydrate homeostasis	GO:0033500	128	0.016
glycoprotein metabolic process	GO:0009100	116	0.016
action potential	GO:0001508	78	0.016
kidney development	GO:0001822	213	0.016
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.016
response to peptide	GO:1901652	136	0.016
spermatogenesis	GO:0007283	284	0.016
regulation of cytoskeleton organization	GO:0051493	122	0.016
muscle tissue development	GO:0060537	308	0.016
purine nucleotide catabolic process	GO:0006195	211	0.016
cell adhesion	GO:0007155	329	0.016
oxidation reduction process	GO:0055114	342	0.015
positive regulation of cellular catabolic process	GO:0031331	148	0.015
regulation of secretion	GO:0051046	274	0.015
regulation of metal ion transport	GO:0010959	106	0.015
cellular response to lipopolysaccharide	GO:0071222	77	0.015
cellular response to molecule of bacterial origin	GO:0071219	83	0.015
purine ribonucleoside metabolic process	GO:0046128	241	0.015
intracellular protein transport	GO:0006886	204	0.015
sensory perception	GO:0007600	245	0.015
tissue homeostasis	GO:0001894	115	0.015
protein ubiquitination	GO:0016567	171	0.015
t cell activation	GO:0042110	289	0.015
chemotaxis	GO:0006935	247	0.015
nitrogen compound transport	GO:0071705	271	0.015
regulation of neuron differentiation	GO:0045664	281	0.015
negative regulation of mitotic cell cycle	GO:0045930	58	0.015
hormone mediated signaling pathway	GO:0009755	23	0.015
viral gene expression	GO:0019080	3	0.015
neuronal action potential	GO:0019228	54	0.015
regulation of vesicle mediated transport	GO:0060627	139	0.015
histone h2a ubiquitination	GO:0033522	3	0.015
positive regulation of cell adhesion	GO:0045785	80	0.014
axonogenesis	GO:0007409	274	0.014
neuron death	GO:0070997	154	0.014
regulation of t cell activation	GO:0050863	170	0.014
mapk cascade	GO:0000165	281	0.014
germ cell development	GO:0007281	185	0.014
negative regulation of phosphorylation	GO:0042326	166	0.014
glycosyl compound metabolic process	GO:1901657	246	0.014
regulation of neuron death	GO:1901214	134	0.014
positive regulation of leukocyte differentiation	GO:1902107	86	0.014
regulation of nucleoside metabolic process	GO:0009118	130	0.014
positive regulation of nucleoside metabolic process	GO:0045979	91	0.014
cellular chemical homeostasis	GO:0055082	215	0.014
carbohydrate derivative catabolic process	GO:1901136	231	0.014
regulation of gtp catabolic process	GO:0033124	113	0.014
negative regulation of cell cycle	GO:0045786	123	0.014
regulation of ion transport	GO:0043269	215	0.014
negative regulation of cellular amine metabolic process	GO:0033239	1	0.014
protein localization to membrane	GO:0072657	108	0.014
regulation of mapk cascade	GO:0043408	248	0.014
negative regulation of phosphate metabolic process	GO:0045936	184	0.014
leukocyte mediated immunity	GO:0002443	174	0.014
neural tube closure	GO:0001843	90	0.013
cellular homeostasis	GO:0019725	240	0.013
organic hydroxy compound metabolic process	GO:1901615	203	0.013
multicellular organism growth	GO:0035264	161	0.013
response to nutrient levels	GO:0031667	109	0.013
cellular response to biotic stimulus	GO:0071216	92	0.013
regulation of cell cycle process	GO:0010564	160	0.013
regulation of secretion by cell	GO:1903530	249	0.013
nucleoside metabolic process	GO:0009116	246	0.013
cytoskeleton dependent intracellular transport	GO:0030705	50	0.013
regulation of proteolysis	GO:0030162	164	0.013
actin filament polymerization	GO:0030041	44	0.013
wnt signaling pathway	GO:0016055	188	0.013
rna catabolic process	GO:0006401	29	0.013
cation homeostasis	GO:0055080	212	0.013
protein maturation	GO:0051604	176	0.013
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.013
regulation of cell adhesion	GO:0030155	154	0.013
regulation of kinase activity	GO:0043549	249	0.013
regulation of protein transport	GO:0051223	163	0.013
regulation of protein catabolic process	GO:0042176	108	0.013
immune effector process	GO:0002252	321	0.013
notch signaling pathway	GO:0007219	71	0.013
plasma membrane organization	GO:0007009	90	0.013
multicellular organismal homeostasis	GO:0048871	164	0.012
dorsal ventral axon guidance	GO:0033563	3	0.012
rho protein signal transduction	GO:0007266	32	0.012
nucleoside triphosphate metabolic process	GO:0009141	230	0.012
extrinsic apoptotic signaling pathway	GO:0097191	126	0.012
positive regulation of cell motility	GO:2000147	116	0.012
nucleoside catabolic process	GO:0009164	206	0.012
positive regulation of neuron differentiation	GO:0045666	141	0.012
response to radiation	GO:0009314	165	0.012
dendrite development	GO:0016358	115	0.012
regulation of excitatory postsynaptic membrane potential	GO:0060079	41	0.012
lipid localization	GO:0010876	126	0.012
protein processing	GO:0016485	163	0.012
covalent chromatin modification	GO:0016569	163	0.012
epithelial tube formation	GO:0072175	130	0.012
negative regulation of molecular function	GO:0044092	258	0.012
spermatid development	GO:0007286	108	0.012
gtp metabolic process	GO:0046039	144	0.012
morphogenesis of embryonic epithelium	GO:0016331	159	0.012
glucose metabolic process	GO:0006006	92	0.012
myeloid cell homeostasis	GO:0002262	114	0.012
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.012
regulation of lymphocyte differentiation	GO:0045619	107	0.012
mitotic cell cycle process	GO:1903047	159	0.012
tumor necrosis factor superfamily cytokine production	GO:0071706	51	0.012
carbon catabolite activation of transcription	GO:0045991	4	0.012
extracellular structure organization	GO:0043062	148	0.012
regulation of cellular component size	GO:0032535	121	0.012
cellular ion homeostasis	GO:0006873	165	0.012
regulation of carbohydrate metabolic process	GO:0006109	75	0.012
cell recognition	GO:0008037	83	0.012
negative regulation of immune system process	GO:0002683	209	0.012
carbon catabolite regulation of transcription	GO:0045990	4	0.012
regulation of protein kinase activity	GO:0045859	232	0.012
smoothened signaling pathway	GO:0007224	105	0.012
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.012
epithelial cell proliferation	GO:0050673	174	0.012
divalent metal ion transport	GO:0070838	172	0.012
cell cell recognition	GO:0009988	44	0.012
cellular response to nutrient levels	GO:0031669	64	0.012
positive regulation of cell development	GO:0010720	237	0.012
digestive tract development	GO:0048565	190	0.012
purine ribonucleoside catabolic process	GO:0046130	205	0.012
response to growth factor	GO:0070848	198	0.012
learning or memory	GO:0007611	148	0.011
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.011
microtubule based transport	GO:0010970	50	0.011
purine ribonucleotide catabolic process	GO:0009154	208	0.011
reactive oxygen species biosynthetic process	GO:1903409	8	0.011
protein localization to plasma membrane	GO:0072659	57	0.011
negative regulation of neuron differentiation	GO:0045665	101	0.011
adult behavior	GO:0030534	135	0.011
anatomical structure homeostasis	GO:0060249	145	0.011
regulation of leukocyte differentiation	GO:1902105	159	0.011
mitochondrion organization	GO:0007005	134	0.011
transmission of nerve impulse	GO:0019226	76	0.011
retrograde transport endosome to golgi	GO:0042147	2	0.011
response to uv	GO:0009411	44	0.011
endocytosis	GO:0006897	168	0.011
positive regulation of hydrolase activity	GO:0051345	148	0.011
lateral inhibition	GO:0046331	1	0.011
sequestering of metal ion	GO:0051238	19	0.011
positive regulation of nucleotide catabolic process	GO:0030813	88	0.011
energy derivation by oxidation of organic compounds	GO:0015980	77	0.011
intrinsic apoptotic signaling pathway	GO:0097193	132	0.011
regulation of actin filament based process	GO:0032970	99	0.011
regulation of ras gtpase activity	GO:0032318	88	0.011
myeloid leukocyte differentiation	GO:0002573	119	0.011
blood circulation	GO:0008015	195	0.011
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.011
carbohydrate biosynthetic process	GO:0016051	74	0.011
histone modification	GO:0016570	159	0.011
regulation of neuron apoptotic process	GO:0043523	122	0.011
neuromuscular process controlling balance	GO:0050885	59	0.011
regulation of transcription from rna polymerase iii promoter	GO:0006359	2	0.011
cellular response to growth factor stimulus	GO:0071363	197	0.011
nucleoside triphosphate catabolic process	GO:0009143	205	0.010
cellular metal ion homeostasis	GO:0006875	151	0.010
protein methylation	GO:0006479	81	0.010
neuron apoptotic process	GO:0051402	142	0.010
anion transport	GO:0006820	177	0.010
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.010
guanosine containing compound metabolic process	GO:1901068	144	0.010
small molecule catabolic process	GO:0044282	71	0.010
carboxylic acid transport	GO:0046942	100	0.010
regulation of establishment of protein localization	GO:0070201	181	0.010
translation	GO:0006412	93	0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.010
multicellular organismal signaling	GO:0035637	91	0.010
regulation of feeding behavior	GO:0060259	3	0.010
bmp signaling pathway	GO:0030509	93	0.010
muscle system process	GO:0003012	141	0.010
adaptive immune response	GO:0002250	155	0.010
negative regulation of cytokine production	GO:0001818	84	0.010
multi multicellular organism process	GO:0044706	109	0.010
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.010
regulation of lipid metabolic process	GO:0019216	118	0.010
single fertilization	GO:0007338	82	0.010
negative regulation of phosphorus metabolic process	GO:0010563	184	0.010
polysaccharide metabolic process	GO:0005976	39	0.010

Appl2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.037
inherited metabolic disorder	DOID:655	0.022
disease of anatomical entity	DOID:7	0.017
nervous system disease	DOID:863	0.017
organ system cancer	DOID:0050686	0.015
cancer	DOID:162	0.015
disease of cellular proliferation	DOID:14566	0.015
central nervous system disease	DOID:331	0.013

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