Mus musculus

64 known processes

Klb

klotho beta

(Aliases: AV071179,betaKlotho)

Klb biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular amine metabolic processGO:0044106440.124
peptidyl amino acid modificationGO:00181933360.115
cellular amino acid metabolic processGO:00065201030.104
amine metabolic processGO:0009308450.096
cation transportGO:00068123990.085
axonogenesisGO:00074092740.082
maintenance of locationGO:0051235890.077
regulation of cellular amine metabolic processGO:0033238200.073
muscle cell differentiationGO:00426922610.073
organic cyclic compound catabolic processGO:19013612950.072
gland developmentGO:00487323300.071
regulation of cellular amino acid metabolic processGO:000652150.068
defense response to other organismGO:00985421970.063
lipid biosynthetic processGO:00086101790.062
regulation of cellular ketone metabolic processGO:0010565660.062
regulation of secretionGO:00510462740.061
negative regulation of endothelial cell migrationGO:001059640.060
regulation of transferase activityGO:00513382630.058
cellular ketone metabolic processGO:0042180840.057
cell fate commitmentGO:00451652100.054
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.053
regulation of cytokine productionGO:00018172660.052
telencephalon developmentGO:00215371860.052
skeletal system developmentGO:00015013560.052
positive regulation of apoptotic processGO:00430652170.051
regulation of protein kinase activityGO:00458592320.051
regulation of cell motilityGO:20001452360.050
regulation of cell activationGO:00508652890.050
innate immune responseGO:00450871570.050
epithelial cell developmentGO:00020641590.048
lipid catabolic processGO:0016042690.046
positive regulation of cell developmentGO:00107202370.045
nucleobase containing small molecule metabolic processGO:00550863520.043
regulation of hormone levelsGO:00108172110.042
nucleoside phosphate metabolic processGO:00067533380.042
regulation of kinase activityGO:00435492490.041
forebrain developmentGO:00309003020.040
epithelial tube morphogenesisGO:00605623030.040
t cell activationGO:00421102890.039
cellular nitrogen compound catabolic processGO:00442702800.039
spermatogenesisGO:00072832840.039
cellular homeostasisGO:00197252400.039
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.039
positive regulation of cell deathGO:00109422240.038
transmembrane transportGO:00550854120.038
aromatic compound catabolic processGO:00194392860.037
organic hydroxy compound metabolic processGO:19016152030.037
cellular lipid metabolic processGO:00442553230.037
immune effector processGO:00022523210.037
carbohydrate metabolic processGO:00059752300.036
positive regulation of programmed cell deathGO:00430682180.036
purine ribonucleoside metabolic processGO:00461282410.036
regionalizationGO:00030023370.036
norepinephrine transportGO:001587420.036
central nervous system neuron differentiationGO:00219531620.036
positive regulation of transferase activityGO:00513471670.035
glycoprotein metabolic processGO:00091001160.035
pallium developmentGO:00215431200.035
cytokine productionGO:00018163190.035
purine nucleotide metabolic processGO:00061633020.034
homeostasis of number of cellsGO:00488722100.033
negative regulation of immune system processGO:00026832090.033
regulation of mapk cascadeGO:00434082480.033
nucleotide metabolic processGO:00091173320.033
purine containing compound metabolic processGO:00725213110.033
cellular response to hormone stimulusGO:00328701500.033
regulation of epithelial cell proliferationGO:00506781410.033
rhythmic processGO:00485111740.033
response to radiationGO:00093141650.033
regulation of lymphocyte activationGO:00512492400.033
germ cell developmentGO:00072811850.032
positive regulation of cellular amine metabolic processGO:003324050.032
ameboidal type cell migrationGO:00016671280.031
endocrine system developmentGO:0035270980.031
camera type eye developmentGO:00430102660.031
monocarboxylic acid metabolic processGO:00327871910.031
positive regulation of mapk cascadeGO:00434101700.031
response to organonitrogen compoundGO:00102432460.031
steroid metabolic processGO:00082021190.031
inflammatory responseGO:00069542440.031
regulation of cell adhesionGO:00301551540.030
chromatin organizationGO:00063252060.030
macromolecule catabolic processGO:00090572810.030
synaptic transmissionGO:00072683290.030
chemotaxisGO:00069352470.030
myeloid cell differentiationGO:00300992330.030
placenta developmentGO:00018901400.030
cellular ion homeostasisGO:00068731650.029
g protein coupled receptor signaling pathwayGO:00071862430.029
cellular response to lipidGO:00713961450.029
response to peptideGO:19016521360.029
positive regulation of protein modification processGO:00314012990.029
negative regulation of phosphorus metabolic processGO:00105631840.028
organic hydroxy compound transportGO:0015850930.028
negative regulation of molecular functionGO:00440922580.028
digestive system developmentGO:00551232000.028
developmental maturationGO:00217001930.028
negative regulation of cellular amino acid metabolic processGO:004576300.028
ribose phosphate metabolic processGO:00196932910.028
lipid localizationGO:00108761260.027
regulation of t cell activationGO:00508631700.027
regulation of cellular catabolic processGO:00313292420.027
negative regulation of cellular component organizationGO:00511291940.027
carbohydrate derivative biosynthetic processGO:19011371830.027
positive regulation of protein kinase activityGO:00458601440.027
nucleoside phosphate catabolic processGO:19012922220.027
oxidation reduction processGO:00551143420.027
Mouse
striated muscle tissue developmentGO:00147062930.027
b cell activationGO:00421131610.027
regulation of organelle organizationGO:00330432890.026
male gamete generationGO:00482322850.026
acylglycerol metabolic processGO:0006639550.026
regulation of leukocyte differentiationGO:19021051590.026
muscle tissue developmentGO:00605373080.026
glycerolipid metabolic processGO:00464861220.026
multicellular organism growthGO:00352641610.026
lymphocyte differentiationGO:00300982420.026
leukocyte differentiationGO:00025213420.026
reactive oxygen species metabolic processGO:0072593840.026
response to growth factorGO:00708481980.026
angiogenesisGO:00015252010.026
sensory organ morphogenesisGO:00905962420.026
regulation of intracellular transportGO:00323861590.025
erythrocyte differentiationGO:0030218880.025
cellular chemical homeostasisGO:00550822150.025
heart morphogenesisGO:00030071780.025
cofactor metabolic processGO:0051186800.025
digestive tract morphogenesisGO:00485461470.025
connective tissue developmentGO:00614481790.025
cation homeostasisGO:00550802120.025
Mouse
reactive nitrogen species metabolic processGO:200105700.024
negative regulation of cell proliferationGO:00082852960.024
chromatin modificationGO:00165681870.024
negative regulation of cellular protein metabolic processGO:00322692470.024
organonitrogen compound biosynthetic processGO:19015661920.024
positive regulation of protein phosphorylationGO:00019342420.024
regulation of system processGO:00440572000.024
regulation of hemostasisGO:1900046280.024
blood vessel morphogenesisGO:00485142850.024
lipid storageGO:0019915360.024
amide transportGO:00428861380.024
hormone metabolic processGO:0042445860.024
ribonucleotide metabolic processGO:00092592910.023
negative regulation of blood vessel endothelial cell migrationGO:004353730.023
positive regulation of cellular amino acid metabolic processGO:004576430.023
histone modificationGO:00165701590.023
cellular divalent inorganic cation homeostasisGO:00725031270.023
activation of immune responseGO:00022531380.023
regulation of cell morphogenesis involved in differentiationGO:00107691510.023
cellular macromolecule catabolic processGO:00442652060.023
regulation of neuron differentiationGO:00456642810.023
negative regulation of phosphate metabolic processGO:00459361840.023
organonitrogen compound catabolic processGO:19015652640.022
endocytosisGO:00068971680.022
respiratory tube developmentGO:00303231670.022
positive regulation of catecholamine secretionGO:003360520.022
nitrogen compound transportGO:00717052710.022
cation transmembrane transportGO:00986552660.022
covalent chromatin modificationGO:00165691630.022
cellular lipid catabolic processGO:0044242520.022
multi multicellular organism processGO:00447061090.022
mapk cascadeGO:00001652810.022
divalent metal ion transportGO:00708381720.022
small molecule biosynthetic processGO:00442831320.022
regulation of reproductive processGO:2000241660.021
protein ubiquitinationGO:00165671710.021
negative regulation of protein metabolic processGO:00512482820.021
divalent inorganic cation transportGO:00725111780.021
sensory perceptionGO:00076002450.021
response to extracellular stimulusGO:00099911270.021
regulation of reactive oxygen species metabolic processGO:2000377400.021
inner ear morphogenesisGO:00424721010.021
dna metabolic processGO:00062593030.021
anatomical structure homeostasisGO:00602491450.021
neutral lipid metabolic processGO:0006638570.021
striated muscle cell developmentGO:00550021250.021
positive regulation of cell motilityGO:20001471160.021
purine ribonucleotide metabolic processGO:00091502900.021
cell recognitionGO:0008037830.021
blood coagulationGO:0007596760.021
sequestering of calcium ionGO:0051208180.020
purine nucleoside catabolic processGO:00061522050.020
organelle localizationGO:00516401790.020
sensory perception of mechanical stimulusGO:00509541070.020
ovulation cycleGO:0042698590.020
negative regulation of cellular amine metabolic processGO:003323910.020
regulation of protein localizationGO:00328802310.020
regulation of vesicle mediated transportGO:00606271390.020
regulation of inflammatory responseGO:00507271470.020
ribonucleoside metabolic processGO:00091192450.019
skeletal muscle organ developmentGO:00605381630.019
lymphocyte proliferationGO:00466511640.019
wound healingGO:00420601570.019
regulation of defense responseGO:00313472330.019
regulation of organ morphogenesisGO:20000271440.019
digestive tract developmentGO:00485651900.019
purine ribonucleotide catabolic processGO:00091542080.019
sterol homeostasisGO:0055092450.019
regulation of membrane potentialGO:00423911920.019
regulation of cellular component biogenesisGO:00440871810.019
regulation of cell migrationGO:00303342190.019
regulation of protein serine threonine kinase activityGO:00719001570.019
skeletal system morphogenesisGO:00487052030.019
leukocyte proliferationGO:00706611720.019
heterocycle catabolic processGO:00467002800.019
cell type specific apoptotic processGO:00972852680.019
glycosyl compound metabolic processGO:19016572460.019
regulation of apoptotic signaling pathwayGO:20012331970.019
purine nucleoside metabolic processGO:00422782410.019
regulation of microvillus assemblyGO:003253430.019
regulation of secretion by cellGO:19035302490.019
coenzyme metabolic processGO:0006732520.019
regulation of lymphocyte proliferationGO:00506701170.018
negative regulation of protein modification processGO:00314001630.018
nucleotide catabolic processGO:00091662170.018
action potentialGO:0001508780.018
meiotic cell cycle processGO:1903046770.018
negative regulation of phosphorylationGO:00423261660.018
response to peptide hormoneGO:00434341270.018
transmission of nerve impulseGO:0019226760.018
saturated monocarboxylic acid metabolic processGO:003278820.018
ion transmembrane transportGO:00342203610.018
organic anion transportGO:00157111370.018
positive regulation of immune effector processGO:00026991070.018
proteoglycan metabolic processGO:0006029380.017
dendrite developmentGO:00163581150.017
response to oxygen levelsGO:0070482620.017
calcium ion transportGO:00068161590.017
regulation of establishment of protein localizationGO:00702011810.017
organophosphate catabolic processGO:00464342320.017
regulation of response to woundingGO:19030341890.017
embryonic organ morphogenesisGO:00485622760.017
neuron projection guidanceGO:00974851410.017
purine containing compound catabolic processGO:00725232130.017
cell growthGO:00160491300.017
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101610.017
regulation of body fluid levelsGO:00508781620.017
purine containing compound biosynthetic processGO:0072522700.017
multicellular organismal signalingGO:0035637910.017
sulfur compound metabolic processGO:00067901000.017
tumor necrosis factor productionGO:0032640500.017
positive regulation of cell activationGO:00508671580.017
response to organic cyclic compoundGO:00140701980.016
response to acid chemicalGO:00011011110.016
stem cell differentiationGO:00488632680.016
regulation of bindingGO:00510981110.016
protein modification by small protein conjugationGO:00324461870.016
nucleoside metabolic processGO:00091162460.016
meiotic nuclear divisionGO:00071261150.016
sequestering of metal ionGO:0051238190.016
cartilage developmentGO:00512161400.016
positive regulation of secretion by cellGO:19035321140.016
vitamin d biosynthetic processGO:004236830.016
response to drugGO:0042493750.016
cell fate specificationGO:0001708720.016
positive regulation of nervous system developmentGO:00519622210.016
t cell differentiationGO:00302171740.016
bone developmentGO:00603481200.016
respiratory system developmentGO:00605411900.016
organic acid transportGO:00158491010.016
regulation of leukocyte proliferationGO:00706631210.016
coagulationGO:0050817780.016
organelle fissionGO:00482851700.015
intracellular receptor signaling pathwayGO:0030522740.015
protein modification by small protein conjugation or removalGO:00706472070.015
cellular component assembly involved in morphogenesisGO:00109271390.015
sensory perception of soundGO:0007605970.015
apoptotic signaling pathwayGO:00971903060.015
protein localization to organelleGO:00333651850.015
regulation of bmp signaling pathwayGO:0030510600.015
cellular response to organic cyclic compoundGO:0071407870.015
cytoplasmic transportGO:00164822340.015
protein catabolic processGO:00301632210.015
glycoprotein biosynthetic processGO:0009101890.015
cellular metal ion homeostasisGO:00068751510.015
immune response regulating signaling pathwayGO:00027641250.015
posttranscriptional regulation of gene expressionGO:00106081550.015
extracellular structure organizationGO:00430621480.015
alcohol metabolic processGO:00060661160.015
epithelial cell proliferationGO:00506731740.015
mitotic cell cycleGO:00002781950.015
cellular response to extracellular stimulusGO:0031668810.015
liver developmentGO:0001889660.015
positive regulation of cell projection organizationGO:0031346950.015
epidermis developmentGO:00085441870.015
tissue remodelingGO:00487711020.015
ribonucleotide catabolic processGO:00092612080.015
endothelial cell migrationGO:0043542440.015
microtubule based processGO:00070172360.015
negative regulation of growthGO:0045926990.015
regulation of homeostatic processGO:00328441820.014
lipid transportGO:0006869980.014
inner ear receptor cell differentiationGO:0060113610.014
nucleoside triphosphate catabolic processGO:00091432050.014
positive regulation of kinase activityGO:00336741550.014
multi organism behaviorGO:0051705620.014
ribonucleoside triphosphate metabolic processGO:00091992200.014
hemostasisGO:0007599780.014
ribonucleoside triphosphate catabolic processGO:00092031990.014
negative regulation of protein phosphorylationGO:00019331260.014
actin cytoskeleton organizationGO:00300362200.014
ribonucleoside catabolic processGO:00424542060.014
regulation of feeding behaviorGO:006025930.014
t cell proliferationGO:00420981200.014
organic hydroxy compound biosynthetic processGO:1901617770.014
regulation of coagulationGO:0050818310.014
response to light stimulusGO:00094161350.014
conditioned taste aversionGO:000166140.014
regulation of cytoplasmic transportGO:19036491120.014
somitogenesisGO:0001756690.014
regulation of circadian rhythmGO:0042752580.014
cerebral cortex developmentGO:0021987860.014
response to oxidative stressGO:00069791230.014
regulation of ion transportGO:00432692150.014
positive regulation of cell adhesionGO:0045785800.014
positive regulation of response to woundingGO:1903036660.014
ear developmentGO:00435832000.014
cell divisionGO:00513011200.014
detection of abiotic stimulusGO:0009582600.014
formation of primary germ layerGO:0001704770.014
positive regulation of homeostatic processGO:0032846640.014
rna processingGO:00063961050.014
humoral immune responseGO:0006959570.014
mesoderm morphogenesisGO:0048332640.014
hematopoietic progenitor cell differentiationGO:00022441430.013
regulation of leukocyte apoptotic processGO:2000106560.013
neural tube developmentGO:00219151600.013
cellular calcium ion homeostasisGO:00068741190.013
regulation of myeloid cell differentiationGO:0045637960.013
cellular response to external stimulusGO:0071496880.013
regulation of tumor necrosis factor productionGO:0032680490.013
carboxylic acid transportGO:00469421000.013
myeloid cell homeostasisGO:00022621140.013
gastrulationGO:00073691160.013
cellular response to peptideGO:1901653920.013
regulation of wnt signaling pathwayGO:00301111230.013
positive regulation of cell migrationGO:00303351090.013
b cell mediated immunityGO:0019724710.013
negative regulation of kinase activityGO:0033673810.013
limbic system developmentGO:0021761720.013
regulation of cell projection organizationGO:00313442060.013
response to insulinGO:00328681000.013
negative regulation of cell developmentGO:00107211690.013
glycosyl compound catabolic processGO:19016582060.013
regulation of protein transportGO:00512231630.013
developmental growth involved in morphogenesisGO:00605601380.013
organ growthGO:00352651170.013
neural tube formationGO:00018411080.013
intracellular protein transportGO:00068862040.013
triglyceride metabolic processGO:0006641510.013
cytosolic calcium ion homeostasisGO:0051480700.013
spermatid differentiationGO:00485151150.013
detection of stimulusGO:0051606840.013
nuclear divisionGO:00002801580.013
negative regulation of apoptotic signaling pathwayGO:20012341040.013
regulation of lipid metabolic processGO:00192161180.013
tube closureGO:0060606910.013
notch signaling pathwayGO:0007219710.013
b cell differentiationGO:0030183780.012
hindbrain developmentGO:00309021280.012
female sex differentiationGO:0046660840.012
negative regulation of intracellular signal transductionGO:19025321670.012
organelle assemblyGO:00709251770.012
inter male aggressive behaviorGO:000212130.012
response to lipopolysaccharideGO:00324961280.012
cellular protein complex assemblyGO:00436231160.012
negative regulation of t cell activationGO:0050868650.012
response to molecule of bacterial originGO:00022371430.012
positive regulation of apoptotic signaling pathwayGO:2001235950.012
establishment or maintenance of cell polarityGO:0007163860.012
glial cell differentiationGO:00100011310.012
digestionGO:0007586400.012
regulation of lipid biosynthetic processGO:0046890540.012
regulation of mitotic cell cycleGO:00073461260.012
positive regulation of protein serine threonine kinase activityGO:00719021060.012
defense response to bacteriumGO:00427421190.012
primary neural tube formationGO:0014020950.012
cellular response to molecule of bacterial originGO:0071219830.012
endomembrane system organizationGO:00102561470.012
regulation of chromosome organizationGO:0033044830.012
regulation of neurotransmitter levelsGO:0001505870.012
cellular response to peptide hormone stimulusGO:0071375920.012
organic acid catabolic processGO:0016054510.012
negative regulation of cell motilityGO:2000146610.012
neuron migrationGO:00017641220.012
cell maturationGO:00484691270.012
positive regulation of secretionGO:00510471300.012
wnt signaling pathwayGO:00160551880.012
regulation of cell cycleGO:00517262810.012
nucleoside catabolic processGO:00091642060.012
activation of transmembrane receptor protein tyrosine kinase activityGO:000717130.012
purine ribonucleoside catabolic processGO:00461302050.011
macromolecule glycosylationGO:0043413550.011
extracellular matrix organizationGO:00301981470.011
negative regulation of cellular response to growth factor stimulusGO:0090288460.011
central nervous system neuron developmentGO:0021954670.011
regulation of interleukin 6 productionGO:0032675550.011
glycosylationGO:0070085620.011
peptidyl tyrosine modificationGO:00182121450.011
triglyceride catabolic processGO:001943390.011
nucleoside phosphate biosynthetic processGO:1901293790.011
bmp signaling pathwayGO:0030509930.011
protein secretionGO:00093061110.011
circadian rhythmGO:00076231140.011
cytokine metabolic processGO:0042107710.011
meiotic cell cycleGO:00513211220.011
metanephric loop of henle developmentGO:007223640.011
succinyl coa metabolic processGO:000610410.011
regulation of interleukin 8 productionGO:003267730.011
embryonic skeletal system developmentGO:00487061200.011
phenol containing compound metabolic processGO:0018958600.011
pharynx developmentGO:006046510.011
mrna metabolic processGO:0016071840.011
negative regulation of cell migrationGO:0030336590.011
purine nucleoside triphosphate catabolic processGO:00091462030.011
cell adhesionGO:00071553290.011
alcohol biosynthetic processGO:0046165430.011
response to transforming growth factor betaGO:0071559880.011
renal system developmentGO:00720012250.011
tube formationGO:00351481400.011
regulation of cell cycle processGO:00105641600.011
regulation of multi organism processGO:00439001110.011
organic hydroxy compound catabolic processGO:1901616250.011
axon guidanceGO:00074111410.011
lung developmentGO:00303241640.011
cellular response to inorganic substanceGO:0071241370.011
positive regulation of epithelial cell proliferationGO:0050679680.011
neuromuscular processGO:0050905990.011
fatty acid metabolic processGO:00066311210.011
blood vessel endothelial cell migrationGO:0043534230.011
regulation of norepinephrine secretionGO:001406120.011
macromolecule methylationGO:00434141200.011
female gamete generationGO:0007292740.011
endothelial cell differentiationGO:0045446410.010
bone mineralizationGO:0030282540.010
myeloid leukocyte differentiationGO:00025731190.010
lateral line system developmentGO:004892510.010
regulation of map kinase activityGO:00434051200.010
development of primary female sexual characteristicsGO:0046545730.010
regulation of cellular response to stressGO:00801351590.010
regulation of endopeptidase activityGO:0052548890.010
microtubule cytoskeleton organizationGO:00002261570.010
multicellular organismal homeostasisGO:00488711640.010
gliogenesisGO:00420631410.010
muscle cell developmentGO:00550011330.010
small molecule catabolic processGO:0044282710.010
positive regulation of keratinocyte proliferationGO:001083840.010
regulation of protein maturationGO:1903317960.010
developmental cell growthGO:0048588840.010
regulation of microvillus organizationGO:003253030.010
amino acid transmembrane transportGO:0003333370.010
regulation of neuron projection developmentGO:00109751690.010
regulation of blood coagulationGO:0030193280.010
organic acid biosynthetic processGO:0016053860.010
transforming growth factor beta receptor signaling pathwayGO:0007179710.010
positive regulation of interleukin 8 productionGO:003275720.010

Klb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.036
disease of anatomical entityDOID:700.036
disease of metabolismDOID:001466700.029
sensory system diseaseDOID:005015500.028
eye and adnexa diseaseDOID:149200.028
eye diseaseDOID:561400.016
retinal degenerationDOID:846600.015
retinal diseaseDOID:567900.015
musculoskeletal system diseaseDOID:1700.014
inherited metabolic disorderDOID:65500.011