Mus musculus

0 known processes

Tle2

transducin-like enhancer of split 2, homolog of Drosophila E(spl)

(Aliases: Grg2,mKIAA4188,KIAA4188)

Tle2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
gtp catabolic processGO:00061841430.170
skeletal system developmentGO:00015013560.147
epithelial tube morphogenesisGO:00605623030.138
positive regulation of cell developmentGO:00107202370.138
Mouse
purine containing compound metabolic processGO:00725213110.119
nucleoside phosphate metabolic processGO:00067533380.118
chemotaxisGO:00069352470.117
nucleobase containing small molecule metabolic processGO:00550863520.107
purine nucleoside catabolic processGO:00061522050.100
positive regulation of gtpase activityGO:0043547850.095
ribonucleotide metabolic processGO:00092592910.085
ribonucleoside metabolic processGO:00091192450.085
purine nucleotide metabolic processGO:00061633020.085
purine containing compound catabolic processGO:00725232130.081
myotube differentiationGO:00149021050.080
regulation of nucleoside metabolic processGO:00091181300.080
bone developmentGO:00603481200.076
purine nucleotide catabolic processGO:00061952110.075
negative regulation of cell proliferationGO:00082852960.073
nucleotide metabolic processGO:00091173320.073
purine ribonucleoside triphosphate metabolic processGO:00092052200.070
embryonic epithelial tube formationGO:00018381300.069
skeletal system morphogenesisGO:00487052030.068
purine ribonucleotide metabolic processGO:00091502900.068
purine ribonucleoside catabolic processGO:00461302050.065
axonogenesisGO:00074092740.065
positive regulation of nucleoside metabolic processGO:0045979910.064
ribose phosphate metabolic processGO:00196932910.064
ribonucleotide catabolic processGO:00092612080.062
positive regulation of nervous system developmentGO:00519622210.060
Mouse
regulation of nucleotide metabolic processGO:00061401690.059
purine ribonucleoside triphosphate catabolic processGO:00092071990.058
sensory perceptionGO:00076002450.057
nucleoside metabolic processGO:00091162460.057
regulation of gtp catabolic processGO:00331241130.056
lung developmentGO:00303241640.056
axon guidanceGO:00074111410.055
neural tube formationGO:00018411080.055
regulation of cell cycleGO:00517262810.055
carbohydrate derivative catabolic processGO:19011362310.053
cartilage developmentGO:00512161400.052
organonitrogen compound catabolic processGO:19015652640.052
cell type specific apoptotic processGO:00972852680.050
positive regulation of gtp catabolic processGO:0033126850.050
glycosyl compound catabolic processGO:19016582060.050
nucleotide catabolic processGO:00091662170.050
central nervous system neuron differentiationGO:00219531620.050
respiratory system developmentGO:00605411900.049
purine nucleoside metabolic processGO:00422782410.049
nucleoside triphosphate metabolic processGO:00091412300.049
kidney developmentGO:00018222130.048
muscle cell differentiationGO:00426922610.048
negative regulation of neuron differentiationGO:00456651010.048
anion transportGO:00068201770.048
kidney epithelium developmentGO:00720731210.046
morphogenesis of a branching structureGO:00017632030.046
connective tissue developmentGO:00614481790.045
membrane organizationGO:00610242450.044
skeletal muscle organ developmentGO:00605381630.044
guanosine containing compound catabolic processGO:19010691440.043
positive regulation of cell deathGO:00109422240.042
positive regulation of purine nucleotide metabolic processGO:19005441140.042
developmental maturationGO:00217001930.042
neuron projection guidanceGO:00974851410.042
bone morphogenesisGO:0060349780.041
cellular amino acid metabolic processGO:00065201030.041
segmentationGO:0035282930.041
organophosphate catabolic processGO:00464342320.040
nephron tubule developmentGO:0072080840.039
purine nucleoside triphosphate catabolic processGO:00091462030.039
protein catabolic processGO:00301632210.039
gtp metabolic processGO:00460391440.039
morphogenesis of embryonic epitheliumGO:00163311590.039
protein modification by small protein conjugationGO:00324461870.038
extracellular structure organizationGO:00430621480.038
nephron epithelium developmentGO:0072009920.038
regulation of cell adhesionGO:00301551540.037
organic cyclic compound catabolic processGO:19013612950.037
purine ribonucleotide catabolic processGO:00091542080.037
negative regulation of nervous system developmentGO:00519611560.036
positive regulation of apoptotic processGO:00430652170.036
regionalizationGO:00030023370.036
negative regulation of cell developmentGO:00107211690.036
cell maturationGO:00484691270.036
cell adhesionGO:00071553290.036
blood vessel morphogenesisGO:00485142850.036
ribonucleoside triphosphate catabolic processGO:00092031990.035
muscle tissue developmentGO:00605373080.035
gonad developmentGO:00084061410.035
forebrain developmentGO:00309003020.035
aromatic compound catabolic processGO:00194392860.034
stem cell developmentGO:00488642190.034
regulation of neuron projection developmentGO:00109751690.034
purine ribonucleoside metabolic processGO:00461282410.034
wnt signaling pathwayGO:00160551880.034
Human Mouse Fly
ribonucleoside triphosphate metabolic processGO:00091992200.034
regulation of cellular amine metabolic processGO:0033238200.033
positive regulation of ras gtpase activityGO:0032320650.033
positive regulation of neuron differentiationGO:00456661410.033
Mouse
neural tube developmentGO:00219151600.033
regulation of ras gtpase activityGO:0032318880.032
small gtpase mediated signal transductionGO:0007264970.032
positive regulation of cellular catabolic processGO:00313311480.032
ear developmentGO:00435832000.032
ossificationGO:00015032160.032
transmembrane transportGO:00550854120.031
response to growth factorGO:00708481980.031
stem cell proliferationGO:00720891170.031
heterocycle catabolic processGO:00467002800.031
primary neural tube formationGO:0014020950.031
peptidyl amino acid modificationGO:00181933360.030
branching morphogenesis of an epithelial tubeGO:00487541590.030
regulation of purine nucleotide catabolic processGO:00331211220.030
hindbrain developmentGO:00309021280.030
stem cell differentiationGO:00488632680.030
tube formationGO:00351481400.030
protein ubiquitinationGO:00165671710.030
regulation of cellular response to stressGO:00801351590.030
regulation of nucleotide catabolic processGO:00308111220.030
striated muscle tissue developmentGO:00147062930.030
regulation of neuron differentiationGO:00456642810.029
Mouse
regulation of wnt signaling pathwayGO:00301111230.029
Human Fly
renal system developmentGO:00720012250.029
epithelial tube formationGO:00721751300.029
positive regulation of programmed cell deathGO:00430682180.028
lymphocyte differentiationGO:00300982420.028
t cell differentiationGO:00302171740.028
positive regulation of protein modification processGO:00314012990.028
metencephalon developmentGO:0022037890.028
positive regulation of hydrolase activityGO:00513451480.027
regulation of cellular ketone metabolic processGO:0010565660.027
neural tube closureGO:0001843900.027
neuron deathGO:00709971540.027
regulation of mitotic cell cycleGO:00073461260.027
extracellular matrix organizationGO:00301981470.026
syncytium formation by plasma membrane fusionGO:0000768420.026
wnt signaling pathway involved in forebrain neuroblast divisionGO:002187420.026
neuron apoptotic processGO:00514021420.026
nucleoside phosphate catabolic processGO:19012922220.026
regulation of neuron deathGO:19012141340.026
guanosine containing compound metabolic processGO:19010681440.025
negative regulation of immune system processGO:00026832090.025
ribonucleoside catabolic processGO:00424542060.025
cellular response to organonitrogen compoundGO:00714171450.025
positive regulation of purine nucleotide catabolic processGO:0033123880.025
regulation of purine nucleotide metabolic processGO:19005421690.025
regulation of cellular amino acid metabolic processGO:000652150.025
regulation of kinase activityGO:00435492490.025
mesonephros developmentGO:0001823970.025
mitotic cell cycleGO:00002781950.025
telencephalon developmentGO:00215371860.025
regulation of protein localizationGO:00328802310.025
positive regulation of cellular amino acid metabolic processGO:004576430.024
protein modification by small protein conjugation or removalGO:00706472070.024
organonitrogen compound biosynthetic processGO:19015661920.024
gland developmentGO:00487323300.024
t cell activationGO:00421102890.024
mesenchymal cell differentiationGO:00487621070.024
dorsal ventral axon guidanceGO:003356330.024
actin cytoskeleton organizationGO:00300362200.024
Fly
compound eye developmentGO:004874910.024
positive regulation of protein serine threonine kinase activityGO:00719021060.024
glucose metabolic processGO:0006006920.024
nucleoside catabolic processGO:00091642060.023
regulation of secretionGO:00510462740.023
regulation of bindingGO:00510981110.023
multi multicellular organism processGO:00447061090.023
response to organonitrogen compoundGO:00102432460.023
carbohydrate derivative biosynthetic processGO:19011371830.023
somite developmentGO:0061053810.023
embryonic organ morphogenesisGO:00485622760.023
purine nucleoside triphosphate metabolic processGO:00091442260.023
positive regulation of nucleotide catabolic processGO:0030813880.023
germ cell developmentGO:00072811850.022
g protein coupled receptor signaling pathwayGO:00071862430.022
nephron epithelium morphogenesisGO:0072088680.022
trachea cartilage morphogenesisGO:006053540.022
nephron tubule morphogenesisGO:0072078680.022
protein palmitoylationGO:0018345140.021
nitrogen compound transportGO:00717052710.021
cytokine productionGO:00018163190.021
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.021
cellular nitrogen compound catabolic processGO:00442702800.021
regulation of cell migrationGO:00303342190.021
nucleoside triphosphate catabolic processGO:00091432050.021
planar cell polarity pathway involved in ventricular septum morphogenesisGO:006134820.021
cell substrate adhesionGO:00315891300.021
positive regulation of nucleotide metabolic processGO:00459811140.021
cellular response to growth factor stimulusGO:00713631970.021
macromolecule catabolic processGO:00090572810.021
regulation of organelle organizationGO:00330432890.021
urogenital system developmentGO:00016552610.021
somitogenesisGO:0001756690.020
regulation of cell projection organizationGO:00313442060.020
glycosyl compound metabolic processGO:19016572460.020
multicellular organism growthGO:00352641610.020
regulation of homeostatic processGO:00328441820.020
amine metabolic processGO:0009308450.020
cation homeostasisGO:00550802120.020
neuron migrationGO:00017641220.020
ion transmembrane transportGO:00342203610.020
cellular amine metabolic processGO:0044106440.020
regulation of hydrolase activityGO:00513362460.020
epithelial cell proliferationGO:00506731740.020
nephron morphogenesisGO:0072028690.020
male gamete generationGO:00482322850.020
t cell selectionGO:0045058340.020
regulation of transferase activityGO:00513382630.020
regulation of feeding behaviorGO:006025930.019
negative regulation of epithelial cell proliferationGO:0050680640.019
response to acid chemicalGO:00011011110.019
regulation of removal of superoxide radicalsGO:200012140.019
regulation of lymphocyte differentiationGO:00456191070.019
negative regulation of molecular functionGO:00440922580.019
positive regulation of protein kinase activityGO:00458601440.019
regulation of multi organism processGO:00439001110.019
regulation of cell activationGO:00508652890.019
skeletal muscle fiber developmentGO:0048741580.019
regulation of neuron apoptotic processGO:00435231220.019
cognitionGO:00508901490.019
non canonical wnt signaling pathway involved in heart developmentGO:006134130.019
morphogenesis of a branching epitheliumGO:00611381930.018
leukocyte differentiationGO:00025213420.018
metanephric nephron developmentGO:0072210340.018
cellular homeostasisGO:00197252400.018
negative regulation of mesenchymal cell proliferationGO:007220130.018
regulation of myotube differentiationGO:0010830620.018
carbohydrate metabolic processGO:00059752300.018
negative regulation of multi organism processGO:0043901680.018
developmental growth involved in morphogenesisGO:00605601380.018
circulatory system processGO:00030131970.018
hindbrain morphogenesisGO:0021575460.018
regulation of jun kinase activityGO:0043506400.018
rho protein signal transductionGO:0007266320.018
mapk cascadeGO:00001652810.018
cation transmembrane transportGO:00986552660.018
cellular chemical homeostasisGO:00550822150.018
regulation of cell morphogenesis involved in differentiationGO:00107691510.017
ras protein signal transductionGO:0007265770.017
regulation of cell cycle processGO:00105641600.017
digestive system developmentGO:00551232000.017
regulation of reproductive processGO:2000241660.017
spermatogenesisGO:00072832840.017
positive regulation of kinase activityGO:00336741550.017
learning or memoryGO:00076111480.017
reactive oxygen species metabolic processGO:0072593840.017
regulation of membrane potentialGO:00423911920.017
heart morphogenesisGO:00030071780.017
regulation of response to woundingGO:19030341890.017
response to light stimulusGO:00094161350.017
cellular ketone metabolic processGO:0042180840.016
metal ion homeostasisGO:00550651890.016
cell recognitionGO:0008037830.016
cellular response to oxygen radicalGO:0071450140.016
negative regulation of leukocyte differentiationGO:1902106510.016
gastrulationGO:00073691160.016
angiogenesisGO:00015252010.016
negative regulation of intracellular signal transductionGO:19025321670.016
cation transportGO:00068123990.016
dna metabolic processGO:00062593030.016
tube closureGO:0060606910.016
muscle cell proliferationGO:0033002520.016
regulation of embryonic developmentGO:0045995710.016
mammary placode formationGO:006059640.016
leukocyte activation involved in immune responseGO:00023661260.016
renal tubule developmentGO:0061326870.015
blood circulationGO:00080151950.015
cellular response to transforming growth factor beta stimulusGO:0071560880.015
renal tubule morphogenesisGO:0061333720.015
cell growthGO:00160491300.015
regulation of cellular catabolic processGO:00313292420.015
regulation of chondrocyte differentiationGO:0032330330.015
cell activation involved in immune responseGO:00022631260.015
response to peptideGO:19016521360.015
regulation of striated muscle cell differentiationGO:0051153810.015
t cell differentiation in thymusGO:0033077770.015
development of primary sexual characteristicsGO:00451371430.015
engulfment of apoptotic cellGO:004365230.015
mesodermal cell migrationGO:000807840.015
regulation of vasculature developmentGO:1901342880.015
regulation of reactive oxygen species metabolic processGO:2000377400.015
ureteric bud developmentGO:0001657940.015
cellular response to acid chemicalGO:0071229680.015
lateral line system developmentGO:004892510.015
cellular calcium ion homeostasisGO:00068741190.015
organelle fissionGO:00482851700.015
regulation of protein serine threonine kinase activityGO:00719001570.015
endocytosisGO:00068971680.015
synaptic transmission glutamatergicGO:0035249360.015
embryonic skeletal system morphogenesisGO:0048704910.015
cyclic nucleotide metabolic processGO:0009187590.015
positive regulation of cellular amine metabolic processGO:003324050.015
regulation of gamma aminobutyric acid secretionGO:001405220.014
proteolysis involved in cellular protein catabolic processGO:00516031470.014
cerebellum developmentGO:0021549770.014
vesicle localizationGO:0051648860.014
cellular metal ion homeostasisGO:00068751510.014
regulation of organ morphogenesisGO:20000271440.014
purine containing compound biosynthetic processGO:0072522700.014
regulation of system processGO:00440572000.014
sequestering of metal ionGO:0051238190.014
nephron developmentGO:00720061090.014
nuclear divisionGO:00002801580.014
canonical wnt signaling pathwayGO:00600701300.014
Human Fly
oocyte axis specificationGO:000730920.014
retina development in camera type eyeGO:00600411190.014
positive regulation of proteolysisGO:0045862850.014
mesenchyme developmentGO:00604851520.014
positive regulation of protein phosphorylationGO:00019342420.014
microtubule based processGO:00070172360.014
pharynx developmentGO:006046510.014
chondrocyte differentiationGO:0002062720.014
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.014
sensory organ morphogenesisGO:00905962420.014
vagus nerve developmentGO:002156430.014
translationGO:0006412930.014
cardiac right atrium morphogenesisGO:000321330.014
mesonephric epithelium developmentGO:0072163940.014
negative regulation of cell cycleGO:00457861230.014
organic hydroxy compound metabolic processGO:19016152030.014
regulation of lymphocyte activationGO:00512492400.014
cellular response to cytokine stimulusGO:00713451890.013
cerebellum morphogenesisGO:0021587420.013
cerebellar cortex developmentGO:0021695480.013
monosaccharide metabolic processGO:00059961060.013
skeletal muscle cell differentiationGO:0035914660.013
positive regulation of cell adhesionGO:0045785800.013
positive regulation of cell motilityGO:20001471160.013
transforming growth factor beta receptor signaling pathwayGO:0007179710.013
ameboidal type cell migrationGO:00016671280.013
response to oxidative stressGO:00069791230.013
notch signaling pathwayGO:0007219710.013
cellular lipid metabolic processGO:00442553230.013
organic anion transportGO:00157111370.013
regulation of cartilage developmentGO:0061035440.013
rhombomere formationGO:002159410.013
negative regulation of cellular component organizationGO:00511291940.013
forebrain generation of neuronsGO:0021872630.013
metanephric loop of henle developmentGO:007223640.013
camera type eye developmentGO:00430102660.013
interleukin 8 productionGO:003263740.013
positive regulation of map kinase activityGO:0043406840.013
female gamete generationGO:0007292740.013
regulation of canonical wnt signaling pathwayGO:0060828820.013
Human Fly
kidney morphogenesisGO:0060993830.013
positive regulation of rho gtpase activityGO:0032321410.013
pallium developmentGO:00215431200.013
regulation of postsynaptic membrane potentialGO:0060078480.012
fat cell differentiationGO:00454441600.012
planar cell polarity pathway involved in pericardium morphogenesisGO:006135420.012
olfactory bulb axon guidanceGO:007167810.012
oogenesisGO:0048477560.012
ureteric bud morphogenesisGO:0060675620.012
regulation of interleukin 8 productionGO:003267730.012
muscle system processGO:00030121410.012
multicellular organismal response to stressGO:0033555620.012
leukocyte migrationGO:00509001240.012
posttranscriptional regulation of gene expressionGO:00106081550.012
cellular divalent inorganic cation homeostasisGO:00725031270.012
exocrine system developmentGO:0035272450.012
cellular response to peptide hormone stimulusGO:0071375920.012
glycoprotein metabolic processGO:00091001160.012
negative regulation of cardiac chamber morphogenesisGO:190122020.012
cerebellar cortex morphogenesisGO:0021696320.012
superoxide metabolic processGO:0006801270.012
oocyte maturationGO:0001556180.012
maintenance of locationGO:0051235890.012
negative regulation of cell projection organizationGO:0031345560.012
regulation of protein transportGO:00512231630.012
planar cell polarity pathway involved in outflow tract morphogenesisGO:006134720.012
inorganic anion transportGO:0015698430.012
sensory perception of mechanical stimulusGO:00509541070.012
cell cycle g1 s phase transitionGO:0044843570.012
mesonephric tubule morphogenesisGO:0072171630.012
regulation of protein catabolic processGO:00421761080.012
glucose homeostasisGO:00425931280.012
regulation of ossificationGO:00302781120.012
positive regulation of muscle cell differentiationGO:0051149390.012
sequestering of calcium ionGO:0051208180.011
epithelial cell developmentGO:00020641590.011
positive regulation of transferase activityGO:00513471670.011
hormone secretionGO:00468791280.011
regulation of cell cycle phase transitionGO:1901987770.011
planar cell polarity pathway involved in heart morphogenesisGO:006134630.011
mitotic cytokinesisGO:000028140.011
regulation of ral gtpase activityGO:003231540.011
appendage morphogenesisGO:00351071490.011
muscle cell developmentGO:00550011330.011
cell fate commitmentGO:00451652100.011
Fly
mitotic cell cycle processGO:19030471590.011
odontogenesisGO:0042476780.011
muscle fiber developmentGO:0048747760.011
forebrain regionalizationGO:0021871250.011
negative regulation of response to woundingGO:1903035770.011
regulation of anion transportGO:0044070270.011
positive regulation of neuron apoptotic processGO:0043525250.011
modification dependent protein catabolic processGO:00199411330.011
cellular protein catabolic processGO:00442571550.011
myotube cell developmentGO:0014904600.011
response to peptide hormoneGO:00434341270.011
cerebellar cortex formationGO:0021697220.011
calcium ion homeostasisGO:00550741270.011
inorganic ion transmembrane transportGO:00986602340.011
monocarboxylic acid metabolic processGO:00327871910.011
cellular response to dna damage stimulusGO:00069742070.011
inorganic cation transmembrane transportGO:00986622070.011
positive regulation of gene silencing by mirnaGO:200063710.011
neuron neuron synaptic transmissionGO:0007270690.011
digestive tract morphogenesisGO:00485461470.011
leukocyte mediated immunityGO:00024431740.011
formation of organ boundaryGO:001016010.011
rac protein signal transductionGO:0016601130.011
mechanoreceptor differentiationGO:0042490670.011
alcohol metabolic processGO:00060661160.011
potassium ion transmembrane transportGO:0071805430.011
regulation of asymmetric cell divisionGO:000978640.011
striated muscle cell proliferationGO:0014855390.011
embryonic skeletal system developmentGO:00487061200.011
negative regulation of cellular protein metabolic processGO:00322692470.011
cerebral cortex developmentGO:0021987860.011
alpha beta t cell differentiationGO:0046632690.011
branching involved in ureteric bud morphogenesisGO:0001658560.011
metanephros developmentGO:0001656790.011
cellular response to insulin stimulusGO:0032869780.011
single organism cell adhesionGO:00986021560.011
regulation of mitotic cell cycle phase transitionGO:1901990730.011
negative regulation of neuron projection developmentGO:0010977500.010
circadian rhythmGO:00076231140.010
cellular response to molecule of bacterial originGO:0071219830.010
carbohydrate homeostasisGO:00335001280.010
protein lipidationGO:0006497280.010
lung alveolus developmentGO:0048286450.010
regulation of protein kinase activityGO:00458592320.010
metanephric s shaped body morphogenesisGO:007228420.010
oocyte anterior posterior axis specificationGO:000731420.010
placenta developmentGO:00018901400.010
regulation of sequence specific dna binding transcription factor activityGO:00510901060.010
defense response to other organismGO:00985421970.010
positive regulation of long term neuronal synaptic plasticityGO:004817030.010
cellular ion homeostasisGO:00068731650.010
anatomical structure maturationGO:0071695490.010
regulation of cell motilityGO:20001452360.010
regulation of defense responseGO:00313472330.010
oocyte differentiationGO:0009994350.010

Tle2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.015
cancerDOID:16200.015
organ system cancerDOID:005068600.015
bone diseaseDOID:008000100.014
connective tissue diseaseDOID:6500.014
disease of anatomical entityDOID:700.014
musculoskeletal system diseaseDOID:1700.014
bone development diseaseDOID:008000600.014
nervous system diseaseDOID:86300.013
osteochondrodysplasiaDOID:225600.012