Mus musculus

38 known processes

Tle6

transducin-like enhancer of split 6, homolog of Drosophila E(spl)

(Aliases: Grg6,1810057E06Rik)

Tle6 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
dna metabolic processGO:00062593030.119
antimicrobial peptide productionGO:000277520.100
macromolecule catabolic processGO:00090572810.081
cellular macromolecule catabolic processGO:00442652060.080
fertilizationGO:00095661270.077
regulation of cellular catabolic processGO:00313292420.071
cellular lipid metabolic processGO:00442553230.065
regulation of cellular amine metabolic processGO:0033238200.062
negative regulation of nik nf kappab signalingGO:190122320.059
establishment or maintenance of bipolar cell polarityGO:0061245210.054
regulation of cell cycleGO:00517262810.054
regulation of toll like receptor 2 signaling pathwayGO:003413530.051
regionalizationGO:00030023370.051
cellular protein complex assemblyGO:00436231160.050
amine metabolic processGO:0009308450.050
regulation of proteolysisGO:00301621640.046
hematopoietic progenitor cell differentiationGO:00022441430.046
modification dependent macromolecule catabolic processGO:00436321330.045
carbohydrate metabolic processGO:00059752300.043
cellular amino acid metabolic processGO:00065201030.042
cellular amine metabolic processGO:0044106440.041
positive regulation of cellular amino acid metabolic processGO:004576430.040
regulation of cellular amino acid metabolic processGO:000652150.040
endocytosisGO:00068971680.039
protein catabolic processGO:00301632210.038
positive regulation of apoptotic processGO:00430652170.037
cytokine productionGO:00018163190.037
cellular response to biotic stimulusGO:0071216920.036
positive regulation of cell deathGO:00109422240.036
leukocyte migrationGO:00509001240.036
lung developmentGO:00303241640.036
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.036
multi multicellular organism processGO:00447061090.035
negative regulation of cellular component organizationGO:00511291940.034
positive regulation of programmed cell deathGO:00430682180.034
cellular ketone metabolic processGO:0042180840.034
cellular nitrogen compound catabolic processGO:00442702800.033
proteolysis involved in cellular protein catabolic processGO:00516031470.033
cellular amide metabolic processGO:0043603580.033
positive regulation of cell developmentGO:00107202370.032
peptide metabolic processGO:0006518460.032
lateral inhibitionGO:004633110.032
positive regulation of proteolysisGO:0045862850.031
ubiquitin dependent protein catabolic processGO:00065111290.031
cell divisionGO:00513011200.031
regulation of antimicrobial humoral responseGO:000275930.031
organonitrogen compound biosynthetic processGO:19015661920.031
striated muscle tissue developmentGO:00147062930.030
antibacterial peptide biosynthetic processGO:000278020.030
activation of mapk activity involved in innate immune responseGO:003541920.030
positive regulation of hydrolase activityGO:00513451480.030
chemotaxisGO:00069352470.029
response to organonitrogen compoundGO:00102432460.029
notch signaling pathwayGO:0007219710.029
cellular response to dna damage stimulusGO:00069742070.029
interspecies interaction between organismsGO:0044419830.028
muscle cell differentiationGO:00426922610.028
cell fate commitmentGO:00451652100.028
cell type specific apoptotic processGO:00972852680.028
regulation of hydrolase activityGO:00513362460.028
positive regulation of protein modification processGO:00314012990.028
immune effector processGO:00022523210.028
regulation of peptidase activityGO:0052547960.027
regulation of cellular ketone metabolic processGO:0010565660.027
organelle assemblyGO:00709251770.027
cation transportGO:00068123990.026
regulation of cell cycle processGO:00105641600.026
skeletal muscle organ developmentGO:00605381630.026
cell substrate adhesionGO:00315891300.026
heterocycle catabolic processGO:00467002800.026
response to lipopolysaccharideGO:00324961280.026
cellular response to organonitrogen compoundGO:00714171450.026
aromatic compound catabolic processGO:00194392860.026
production of molecular mediator of immune responseGO:00024401030.025
nucleobase containing small molecule metabolic processGO:00550863520.025
cation transmembrane transportGO:00986552660.025
peptidyl amino acid modificationGO:00181933360.025
dna repairGO:00062811070.024
positive regulation of nervous system developmentGO:00519622210.024
positive regulation of cellular amine metabolic processGO:003324050.024
establishment or maintenance of cell polarityGO:0007163860.024
regulation of antimicrobial peptide productionGO:000278410.024
ribonucleoside triphosphate metabolic processGO:00091992200.024
positive regulation of neuron differentiationGO:00456661410.024
skeletal system morphogenesisGO:00487052030.024
spermatogenesisGO:00072832840.024
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002824610.023
response to molecule of bacterial originGO:00022371430.023
regulation of antibacterial peptide productionGO:000278610.023
regulation of protein localizationGO:00328802310.023
negative regulation of immune system processGO:00026832090.022
skeletal system developmentGO:00015013560.022
regulation of canonical wnt signaling pathwayGO:0060828820.022
positive regulation of protein transportGO:0051222930.022
muscle tissue developmentGO:00605373080.022
cell adhesionGO:00071553290.022
negative regulation of molecular functionGO:00440922580.022
fat cell differentiationGO:00454441600.022
bone developmentGO:00603481200.022
lymphocyte mediated immunityGO:00024491390.021
microtubule cytoskeleton organization involved in mitosisGO:190285040.021
regulation of establishment of protein localizationGO:00702011810.021
intracellular protein transportGO:00068862040.021
respiratory system developmentGO:00605411900.021
negative regulation of cell cycleGO:00457861230.021
spleen developmentGO:0048536390.021
microtubule based processGO:00070172360.020
regulation of protein transportGO:00512231630.020
membrane organizationGO:00610242450.020
regulation of prostaglandin endoperoxide synthase activityGO:006058420.020
lipid biosynthetic processGO:00086101790.020
positive regulation of antimicrobial peptide productionGO:000222510.020
activation of immune responseGO:00022531380.020
nucleoside metabolic processGO:00091162460.020
cytoplasmic transportGO:00164822340.019
myotube differentiationGO:00149021050.019
neural tube developmentGO:00219151600.019
regulation of interferon gamma productionGO:0032649570.019
regulation of sequence specific dna binding transcription factor activityGO:00510901060.019
regulation of secretionGO:00510462740.019
negative regulation of intracellular signal transductionGO:19025321670.019
positive regulation of peptidase activityGO:0010952490.019
negative regulation of macrophage apoptotic processGO:200011030.019
protein processingGO:00164851630.019
negative regulation of protein metabolic processGO:00512482820.019
smoothened signaling pathwayGO:00072241050.018
positive regulation of cytokine productionGO:00018191740.018
innate immune response in mucosaGO:000222730.018
regulation of organelle organizationGO:00330432890.018
positive regulation of endopeptidase activityGO:0010950430.018
chromatin organizationGO:00063252060.018
oxidation reduction processGO:00551143420.018
negative regulation of immune effector processGO:0002698550.018
symbiosis encompassing mutualism through parasitismGO:0044403830.018
regulation of cellular component biogenesisGO:00440871810.018
positive regulation of cell cycleGO:0045787920.018
antibacterial humoral responseGO:001973180.017
regulation of lymphocyte activationGO:00512492400.017
regulation of protein maturationGO:1903317960.017
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280360.017
inorganic ion transmembrane transportGO:00986602340.017
modification dependent protein catabolic processGO:00199411330.017
apoptotic signaling pathwayGO:00971903060.017
mitotic cell cycleGO:00002781950.017
axonogenesisGO:00074092740.017
germ cell developmentGO:00072811850.017
nucleoside phosphate catabolic processGO:19012922220.017
regulation of endopeptidase activityGO:0052548890.017
cellular response to oxidative stressGO:0034599760.017
regulation of fat cell differentiationGO:0045598810.017
canonical wnt signaling pathwayGO:00600701300.017
regulation of striated muscle cell differentiationGO:0051153810.017
organic hydroxy compound metabolic processGO:19016152030.017
nitrogen compound transportGO:00717052710.017
reactive oxygen species metabolic processGO:0072593840.017
sensory perceptionGO:00076002450.017
response to organic cyclic compoundGO:00140701980.017
leukocyte chemotaxisGO:0030595690.017
glycosyl compound metabolic processGO:19016572460.017
regulation of neuron differentiationGO:00456642810.017
positive regulation of antimicrobial peptide biosynthetic processGO:000280710.017
rho protein signal transductionGO:0007266320.017
positive regulation of cysteine type endopeptidase activityGO:2001056390.017
regulation of protein kinase activityGO:00458592320.017
cell cycle checkpointGO:0000075470.017
regulation of mapk cascadeGO:00434082480.016
positive regulation of immune effector processGO:00026991070.016
asymmetric stem cell divisionGO:009872230.016
organic cyclic compound catabolic processGO:19013612950.016
response to oxidative stressGO:00069791230.016
central nervous system neuron differentiationGO:00219531620.016
transforming growth factor beta receptor signaling pathwayGO:0007179710.016
negative regulation of wnt signaling pathwayGO:0030178730.016
ion transmembrane transportGO:00342203610.016
protein modification by small protein conjugation or removalGO:00706472070.016
negative regulation of protein catabolic processGO:0042177360.016
positive regulation of protein kinase activityGO:00458601440.016
intracellular receptor signaling pathwayGO:0030522740.016
inorganic cation transmembrane transportGO:00986622070.016
cell chemotaxisGO:0060326810.016
b cell activationGO:00421131610.016
mesoderm developmentGO:00074981000.016
transmembrane transportGO:00550854120.016
regulation of interleukin 8 productionGO:003267730.016
myeloid leukocyte migrationGO:0097529570.016
regulation of cell activationGO:00508652890.016
purine nucleoside metabolic processGO:00422782410.016
regulation of inflammatory responseGO:00507271470.016
digestive tract developmentGO:00485651900.016
dna methylation involved in gamete generationGO:0043046150.016
regulation of mitotic cell cycle phase transitionGO:1901990730.016
humoral immune responseGO:0006959570.016
phospholipid metabolic processGO:0006644870.016
response to peptideGO:19016521360.016
regulation of cell cycle phase transitionGO:1901987770.016
i kappab kinase nf kappab signalingGO:0007249850.015
positive regulation of kinase activityGO:00336741550.015
regulation of adaptive immune responseGO:0002819900.015
regulation of ossificationGO:00302781120.015
regulation of symbiosis encompassing mutualism through parasitismGO:0043903520.015
interleukin 8 productionGO:003263740.015
camera type eye developmentGO:00430102660.015
leukocyte mediated immunityGO:00024431740.015
purine ribonucleoside triphosphate catabolic processGO:00092071990.015
purine ribonucleoside metabolic processGO:00461282410.015
ribonucleoside catabolic processGO:00424542060.015
protein modification by small protein conjugationGO:00324461870.015
inflammatory responseGO:00069542440.015
wound healingGO:00420601570.015
regulation of cellular response to stressGO:00801351590.015
digestive system developmentGO:00551232000.015
midbrain hindbrain boundary developmentGO:003091790.015
regulation of protein processingGO:0070613960.015
negative regulation of interleukin 2 productionGO:003270380.015
negative regulation of multi organism processGO:0043901680.015
blood vessel morphogenesisGO:00485142850.015
compound eye developmentGO:004874910.015
regulation of cell adhesionGO:00301551540.015
antibacterial peptide productionGO:000277820.015
regulation of cell motilityGO:20001452360.015
regulation of secretion by cellGO:19035302490.014
epithelial tube formationGO:00721751300.014
response to inorganic substanceGO:0010035960.014
regulation of response to woundingGO:19030341890.014
immune response regulating signaling pathwayGO:00027641250.014
connective tissue developmentGO:00614481790.014
ossificationGO:00015032160.014
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281620.014
regulation of defense response to bacteriumGO:190042430.014
regulation of wnt signaling pathwayGO:00301111230.014
stem cell differentiationGO:00488632680.014
protein ubiquitinationGO:00165671710.014
positive regulation of protein phosphorylationGO:00019342420.014
negative regulation of cell developmentGO:00107211690.014
regulation of antibacterial peptide biosynthetic processGO:000280810.014
regulation of autophagyGO:0010506300.014
muscle cell developmentGO:00550011330.014
positive regulation of leukocyte mediated immunityGO:0002705700.014
chromatin modificationGO:00165681870.014
mapk cascadeGO:00001652810.014
myeloid cell differentiationGO:00300992330.014
ras protein signal transductionGO:0007265770.014
positive regulation of transferase activityGO:00513471670.014
innate immune responseGO:00450871570.014
male gonad developmentGO:0008584880.014
male sex differentiationGO:00466611090.014
regulation of hormone levelsGO:00108172110.014
nucleoside phosphate metabolic processGO:00067533380.014
regulation of reproductive processGO:2000241660.014
regulation of system processGO:00440572000.014
small molecule biosynthetic processGO:00442831320.014
embryonic placenta developmentGO:0001892980.014
placenta developmentGO:00018901400.014
oocyte constructionGO:000730820.014
meiosis iGO:0007127600.014
ribonucleotide catabolic processGO:00092612080.014
heart morphogenesisGO:00030071780.013
fatty acid metabolic processGO:00066311210.013
activation of mapk activityGO:0000187590.013
small gtpase mediated signal transductionGO:0007264970.013
regulation of leukocyte mediated immunityGO:00027031040.013
response to acid chemicalGO:00011011110.013
posttranscriptional regulation of gene expressionGO:00106081550.013
nucleotide metabolic processGO:00091173320.013
nucleoside triphosphate catabolic processGO:00091432050.013
regulation of synaptic growth at neuromuscular junctionGO:000858240.013
hexose metabolic processGO:0019318980.013
respiratory tube developmentGO:00303231670.013
regulation of inflammatory response to antigenic stimulusGO:0002861210.013
alcohol metabolic processGO:00060661160.013
nuclear divisionGO:00002801580.013
response to growth factorGO:00708481980.013
phagocytosisGO:0006909660.013
organophosphate catabolic processGO:00464342320.013
regulation of myotube differentiationGO:0010830620.013
regulation of multi organism processGO:00439001110.013
negative regulation of phosphate metabolic processGO:00459361840.013
regulation of cell migrationGO:00303342190.013
tube formationGO:00351481400.013
stem cell proliferationGO:00720891170.013
regulation of intracellular transportGO:00323861590.013
carbohydrate derivative catabolic processGO:19011362310.013
locomotory behaviorGO:00076261950.013
chromosome segregationGO:0007059480.013
rna interferenceGO:001624620.013
establishment or maintenance of apical basal cell polarityGO:0035088210.013
nuclear transportGO:00511691390.013
regulation of epithelial cell proliferationGO:00506781410.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.013
purine containing compound metabolic processGO:00725213110.013
purine ribonucleotide catabolic processGO:00091542080.013
positive regulation of sequence specific dna binding transcription factor activityGO:0051091680.013
organelle localizationGO:00516401790.013
gonad developmentGO:00084061410.013
tube closureGO:0060606910.013
positive regulation of production of molecular mediator of immune responseGO:0002702450.013
methylationGO:00322591340.013
glycerophospholipid metabolic processGO:0006650710.012
neuron deathGO:00709971540.012
helper t cell enhancement of adaptive immune responseGO:003539710.012
cellular protein catabolic processGO:00442571550.012
positive regulation of protein modification by small protein conjugation or removalGO:1903322300.012
regulation of antimicrobial peptide biosynthetic processGO:000280510.012
regulation of body fluid levelsGO:00508781620.012
purine nucleotide metabolic processGO:00061633020.012
positive regulation of notch signaling pathwayGO:0045747180.012
epithelial cell proliferationGO:00506731740.012
positive regulation of cellular catabolic processGO:00313311480.012
cellular homeostasisGO:00197252400.012
positive regulation of protein serine threonine kinase activityGO:00719021060.012
regulation of interleukin 18 productionGO:003266130.012
negative regulation of cellular protein metabolic processGO:00322692470.012
mitotic nuclear divisionGO:0007067480.012
regulation of defense responseGO:00313472330.012
cellular response to lipidGO:00713961450.012
male genitalia morphogenesisGO:004880840.012
cellular response to molecule of bacterial originGO:0071219830.012
epithelial tube morphogenesisGO:00605623030.012
determination of left right symmetryGO:0007368800.012
nucleocytoplasmic transportGO:00069131390.012
ribonucleotide metabolic processGO:00092592910.012
regulation of transferase activityGO:00513382630.012
positive regulation of secretion by cellGO:19035321140.012
metanephric loop of henle developmentGO:007223640.012
immune response activating signal transductionGO:00027571160.012
developmental maturationGO:00217001930.012
cardiac chamber morphogenesisGO:0003206930.012
embryonic organ morphogenesisGO:00485622760.012
glucose metabolic processGO:0006006920.012
positive regulation of antibacterial peptide biosynthetic processGO:000696310.012
peptide biosynthetic processGO:0043043110.012
synapse organizationGO:00508081250.012
cell maturationGO:00484691270.012
circulatory system processGO:00030131970.012
peptide transportGO:00158331330.012
antimicrobial peptide biosynthetic processGO:000277720.012
organonitrogen compound catabolic processGO:19015652640.012
neural tube formationGO:00018411080.011
regulation of protein modification by small protein conjugation or removalGO:1903320570.011
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.011
male gamete generationGO:00482322850.011
epidermis developmentGO:00085441870.011
positive regulation of purine nucleotide catabolic processGO:0033123880.011
nucleoside triphosphate metabolic processGO:00091412300.011
positive regulation of purine nucleotide metabolic processGO:19005441140.011
nuclear importGO:0051170950.011
negative regulation of cellular catabolic processGO:0031330470.011
actin filament organizationGO:00070151130.011
negative regulation of protein processingGO:0010955790.011
antigen processing and presentationGO:0019882470.011
protein localization to organelleGO:00333651850.011
sodium ion transportGO:0006814730.011
negative regulation of protein maturationGO:1903318790.011
steroid metabolic processGO:00082021190.011
protein palmitoylationGO:0018345140.011
regulation of chemotaxisGO:0050920530.011
regulation of protein catabolic processGO:00421761080.011
action potentialGO:0001508780.011
morphogenesis of embryonic epitheliumGO:00163311590.011
macromolecule methylationGO:00434141200.011
positive regulation of defense response to bacteriumGO:190042610.011
hormone secretionGO:00468791280.011
regulation of protein complex assemblyGO:0043254830.011
negative regulation of mitotic cell cycleGO:0045930580.011
activation of cysteine type endopeptidase activityGO:0097202270.011
protein importGO:00170381010.011
exocytosisGO:00068871210.011
glycoprotein metabolic processGO:00091001160.011
cytokine secretionGO:0050663720.011
growth of symbiont in hostGO:0044117230.011
purine nucleoside triphosphate metabolic processGO:00091442260.011
regulation of apoptotic signaling pathwayGO:20012331970.011
negative regulation of cellular amino acid metabolic processGO:004576300.011
carbohydrate derivative biosynthetic processGO:19011371830.011
regulation of cytokine productionGO:00018172660.011
pole plasm assemblyGO:000731520.011
positive regulation of lymphocyte mediated immunityGO:0002708620.011
defense response to gram positive bacteriumGO:0050830500.011
pharynx developmentGO:006046510.011
skeletal muscle cell differentiationGO:0035914660.011
blood circulationGO:00080151950.011
pattern recognition receptor signaling pathwayGO:0002221470.011
asymmetric neuroblast divisionGO:005505910.011
tumor necrosis factor productionGO:0032640500.011
cellular response to transforming growth factor beta stimulusGO:0071560880.011
divalent metal ion transportGO:00708381720.011
innate immune response activating signal transductionGO:0002758500.011
regulation of reactive oxygen species metabolic processGO:2000377400.011
purine nucleotide catabolic processGO:00061952110.011
regulation of mitotic cell cycleGO:00073461260.011
wnt signaling pathwayGO:00160551880.011
Mouse
positive regulation of secretionGO:00510471300.011
negative regulation of sequence specific dna binding transcription factor activityGO:0043433400.011
regulation of protein serine threonine kinase activityGO:00719001570.011
t cell activationGO:00421102890.011
myeloid cell homeostasisGO:00022621140.011
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.011
negative regulation of cell activationGO:00508661110.010
gtp metabolic processGO:00460391440.010
regulation of production of molecular mediator of immune responseGO:0002700650.010
positive regulation of interleukin 1 beta productionGO:0032731160.010
purine ribonucleotide metabolic processGO:00091502900.010
urogenital system developmentGO:00016552610.010
segmentationGO:0035282930.010
ribose phosphate metabolic processGO:00196932910.010
protein localization to nucleusGO:00345041210.010
protein maturationGO:00516041760.010
stem cell developmentGO:00488642190.010
positive regulation of nucleoside metabolic processGO:0045979910.010
mitotic sister chromatid separationGO:005130690.010
development of primary male sexual characteristicsGO:0046546880.010
cellular carbohydrate metabolic processGO:00442621190.010
alpha amino acid metabolic processGO:1901605590.010
regulation of cellular response to oxidative stressGO:1900407190.010
lymphocyte proliferationGO:00466511640.010
positive regulation of interleukin 8 productionGO:003275720.010
regulation of lymphocyte mediated immunityGO:0002706840.010
peptidyl tyrosine phosphorylationGO:00181081430.010
regulation of purine nucleotide metabolic processGO:19005421690.010
nucleoside catabolic processGO:00091642060.010
interferon gamma productionGO:0032609670.010
hindbrain developmentGO:00309021280.010
blastocyst developmentGO:0001824800.010

Tle6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.023
nervous system diseaseDOID:86300.023
musculoskeletal system diseaseDOID:1700.012
sensory system diseaseDOID:005015500.010
eye and adnexa diseaseDOID:149200.010
eye diseaseDOID:561400.010