| protein modification by small protein conjugation | GO:0032446 | 187 | 0.359 | Fly |
| ras protein signal transduction | GO:0007265 | 77 | 0.331 | |
| response to peptide hormone | GO:0043434 | 127 | 0.202 | |
| olfactory learning | GO:0008355 | 2 | 0.153 | |
| compound eye development | GO:0048749 | 1 | 0.143 | |
| negative regulation of protein metabolic process | GO:0051248 | 282 | 0.120 | Fly |
| oocyte construction | GO:0007308 | 2 | 0.117 | |
| oocyte axis specification | GO:0007309 | 2 | 0.106 | |
| protein modification by small protein conjugation or removal | GO:0070647 | 207 | 0.098 | Fly |
| cellular response to peptide | GO:1901653 | 92 | 0.097 | |
| cellular protein catabolic process | GO:0044257 | 155 | 0.092 | |
| cellular homeostasis | GO:0019725 | 240 | 0.089 | |
| microtubule cytoskeleton organization | GO:0000226 | 157 | 0.088 | |
| protein ubiquitination | GO:0016567 | 171 | 0.087 | Fly |
| macromolecule catabolic process | GO:0009057 | 281 | 0.087 | |
| negative regulation of intracellular signal transduction | GO:1902532 | 167 | 0.086 | Human |
| oxidation reduction process | GO:0055114 | 342 | 0.085 | |
| regulation of cell cycle | GO:0051726 | 281 | 0.083 | Fly |
| positive regulation of protein modification process | GO:0031401 | 299 | 0.080 | Fly |
| stem cell differentiation | GO:0048863 | 268 | 0.074 | |
| respiratory system development | GO:0060541 | 190 | 0.069 | Fly |
| fatty acid metabolic process | GO:0006631 | 121 | 0.069 | |
| response to peptide | GO:1901652 | 136 | 0.068 | |
| macromolecule methylation | GO:0043414 | 120 | 0.067 | |
| cellular response to organonitrogen compound | GO:0071417 | 145 | 0.064 | |
| cation transport | GO:0006812 | 399 | 0.064 | |
| synaptic vesicle membrane organization | GO:0048499 | 1 | 0.064 | |
| adherens junction maintenance | GO:0034334 | 1 | 0.062 | |
| cellular chemical homeostasis | GO:0055082 | 215 | 0.057 | |
| apoptotic signaling pathway | GO:0097190 | 306 | 0.056 | |
| regulation of cardioblast differentiation | GO:0051890 | 3 | 0.055 | |
| small gtpase mediated signal transduction | GO:0007264 | 97 | 0.054 | |
| establishment or maintenance of microtubule cytoskeleton polarity | GO:0030951 | 1 | 0.054 | |
| vesicle organization | GO:0016050 | 60 | 0.052 | |
| cell fate commitment | GO:0045165 | 210 | 0.051 | |
| protein catabolic process | GO:0030163 | 221 | 0.051 | |
| positive regulation of cellular protein catabolic process | GO:1903364 | 34 | 0.050 | |
| cytoplasmic transport | GO:0016482 | 234 | 0.050 | Human |
| cilium morphogenesis | GO:0060271 | 102 | 0.049 | |
| cellular response to insulin stimulus | GO:0032869 | 78 | 0.048 | |
| purine nucleotide metabolic process | GO:0006163 | 302 | 0.047 | |
| regulation of histone h3 k27 methylation | GO:0061085 | 6 | 0.047 | |
| regionalization | GO:0003002 | 337 | 0.046 | |
| response to insulin | GO:0032868 | 100 | 0.046 | |
| cellularization | GO:0007349 | 1 | 0.046 | |
| cellular ketone metabolic process | GO:0042180 | 84 | 0.045 | |
| chromatin organization | GO:0006325 | 206 | 0.045 | |
| modification dependent macromolecule catabolic process | GO:0043632 | 133 | 0.042 | |
| purine ribonucleotide catabolic process | GO:0009154 | 208 | 0.041 | |
| sensory system development | GO:0048880 | 3 | 0.040 | |
| dna metabolic process | GO:0006259 | 303 | 0.040 | |
| negative regulation of dendritic spine morphogenesis | GO:0061002 | 3 | 0.038 | |
| sodium ion transmembrane transport | GO:0035725 | 49 | 0.037 | |
| mrna transport | GO:0051028 | 13 | 0.037 | |
| rna localization | GO:0006403 | 23 | 0.037 | |
| negative regulation of phosphate metabolic process | GO:0045936 | 184 | 0.037 | Fly |
| carbohydrate metabolic process | GO:0005975 | 230 | 0.037 | |
| germ cell development | GO:0007281 | 185 | 0.036 | Fly |
| cellular response to hormone stimulus | GO:0032870 | 150 | 0.035 | |
| regulation of mapk cascade | GO:0043408 | 248 | 0.035 | |
| transmembrane receptor protein tyrosine kinase signaling pathway | GO:0007169 | 247 | 0.034 | Fly |
| actin cytoskeleton organization | GO:0030036 | 220 | 0.034 | |
| retrograde transport endosome to golgi | GO:0042147 | 2 | 0.033 | |
| protein localization to organelle | GO:0033365 | 185 | 0.033 | Human |
| mapk cascade | GO:0000165 | 281 | 0.033 | |
| activation of jnkk activity | GO:0007256 | 3 | 0.033 | |
| negative regulation of phosphorylation | GO:0042326 | 166 | 0.032 | Fly |
| response to organonitrogen compound | GO:0010243 | 246 | 0.032 | |
| oocyte anterior posterior axis specification | GO:0007314 | 2 | 0.031 | |
| ribose phosphate metabolic process | GO:0019693 | 291 | 0.031 | |
| microtubule based process | GO:0007017 | 236 | 0.029 | |
| regulation of cellular amine metabolic process | GO:0033238 | 20 | 0.029 | |
| positive regulation of homeostatic process | GO:0032846 | 64 | 0.029 | |
| regulation of cellular ketone metabolic process | GO:0010565 | 66 | 0.029 | |
| intracellular mrna localization | GO:0008298 | 4 | 0.029 | |
| aromatic compound catabolic process | GO:0019439 | 286 | 0.028 | |
| extracellular structure organization | GO:0043062 | 148 | 0.028 | |
| negative regulation of immune system process | GO:0002683 | 209 | 0.028 | |
| defecation | GO:0030421 | 1 | 0.028 | |
| development of primary sexual characteristics | GO:0045137 | 143 | 0.028 | |
| positive regulation of transferase activity | GO:0051347 | 167 | 0.027 | |
| maternal determination of anterior posterior axis embryo | GO:0008358 | 2 | 0.027 | |
| protein localization to plasma membrane | GO:0072659 | 57 | 0.027 | |
| cell cycle switching | GO:0060184 | 1 | 0.027 | |
| germline cell cycle switching mitotic to meiotic cell cycle | GO:0051729 | 1 | 0.026 | |
| mitotic cell cycle | GO:0000278 | 195 | 0.026 | |
| establishment or maintenance of cell polarity | GO:0007163 | 86 | 0.025 | |
| asymmetric stem cell division | GO:0098722 | 3 | 0.025 | |
| regulation of rna export from nucleus | GO:0046831 | 4 | 0.025 | |
| regulation of fatty acid biosynthetic process | GO:0042304 | 12 | 0.025 | |
| ion transmembrane transport | GO:0034220 | 361 | 0.025 | |
| cellular nitrogen compound catabolic process | GO:0044270 | 280 | 0.025 | |
| ribonucleoprotein complex disassembly | GO:0032988 | 3 | 0.024 | |
| inorganic cation transmembrane transport | GO:0098662 | 207 | 0.024 | |
| negative regulation of triglyceride metabolic process | GO:0090209 | 4 | 0.024 | |
| glycoprotein metabolic process | GO:0009100 | 116 | 0.024 | |
| ectodermal cell differentiation | GO:0010668 | 3 | 0.024 | |
| cilium assembly | GO:0042384 | 81 | 0.023 | |
| establishment of protein localization to membrane | GO:0090150 | 54 | 0.023 | |
| cellular amine metabolic process | GO:0044106 | 44 | 0.023 | |
| negative regulation of cell cycle | GO:0045786 | 123 | 0.023 | |
| leukocyte apoptotic process | GO:0071887 | 71 | 0.023 | |
| rab protein signal transduction | GO:0032482 | 1 | 0.023 | |
| methylation | GO:0032259 | 134 | 0.023 | |
| plasma membrane organization | GO:0007009 | 90 | 0.023 | |
| cellular response to peptide hormone stimulus | GO:0071375 | 92 | 0.023 | |
| regulation of protein binding | GO:0043393 | 60 | 0.022 | |
| histone lysine methylation | GO:0034968 | 50 | 0.022 | |
| positive regulation of protein phosphorylation | GO:0001934 | 242 | 0.022 | |
| locomotory behavior | GO:0007626 | 195 | 0.022 | |
| transmembrane transport | GO:0055085 | 412 | 0.022 | |
| positive regulation of necrotic cell death | GO:0010940 | 1 | 0.022 | |
| regulation of kinase activity | GO:0043549 | 249 | 0.021 | |
| regulation of transferase activity | GO:0051338 | 263 | 0.021 | |
| organic cyclic compound catabolic process | GO:1901361 | 295 | 0.021 | |
| cardiac cell fate specification | GO:0060912 | 2 | 0.021 | |
| regulation of protein catabolic process | GO:0042176 | 108 | 0.021 | |
| nucleic acid transport | GO:0050657 | 18 | 0.021 | |
| negative regulation of molecular function | GO:0044092 | 258 | 0.021 | |
| negative regulation of cell fate specification | GO:0009996 | 4 | 0.021 | |
| nucleobase containing small molecule metabolic process | GO:0055086 | 352 | 0.021 | |
| neural precursor cell proliferation | GO:0061351 | 121 | 0.021 | |
| carbohydrate derivative biosynthetic process | GO:1901137 | 183 | 0.020 | |
| establishment of rna localization | GO:0051236 | 18 | 0.020 | |
| purine containing compound metabolic process | GO:0072521 | 311 | 0.020 | |
| cellular response to extracellular stimulus | GO:0031668 | 81 | 0.020 | |
| nuclear transport | GO:0051169 | 139 | 0.020 | |
| nucleotide catabolic process | GO:0009166 | 217 | 0.020 | |
| negative regulation of protein modification process | GO:0031400 | 163 | 0.020 | Fly |
| positive regulation of histone h3 k27 methylation | GO:0061087 | 4 | 0.020 | |
| positive regulation of purine nucleotide metabolic process | GO:1900544 | 114 | 0.020 | |
| multicellular organism growth | GO:0035264 | 161 | 0.019 | |
| purine nucleotide catabolic process | GO:0006195 | 211 | 0.019 | |
| erbb signaling pathway | GO:0038127 | 32 | 0.019 | Fly |
| calcium ion transport | GO:0006816 | 159 | 0.019 | |
| positive regulation of proteasomal ubiquitin dependent protein catabolic process | GO:0032436 | 23 | 0.019 | |
| polysaccharide biosynthetic process | GO:0000271 | 20 | 0.019 | |
| regulation of stem cell differentiation | GO:2000736 | 50 | 0.019 | |
| lateral line system development | GO:0048925 | 1 | 0.019 | |
| cell division | GO:0051301 | 120 | 0.019 | |
| regulation of proteolysis | GO:0030162 | 164 | 0.018 | |
| regulation of lymphocyte anergy | GO:0002911 | 4 | 0.018 | |
| epidermal growth factor receptor signaling pathway | GO:0007173 | 28 | 0.018 | Fly |
| ribonucleoside metabolic process | GO:0009119 | 245 | 0.018 | |
| carbohydrate derivative catabolic process | GO:1901136 | 231 | 0.018 | |
| engulfment of apoptotic cell | GO:0043652 | 3 | 0.018 | |
| maintenance of location | GO:0051235 | 89 | 0.018 | |
| clathrin coat assembly | GO:0048268 | 2 | 0.018 | |
| regulation of intracellular transport | GO:0032386 | 159 | 0.017 | |
| protein alkylation | GO:0008213 | 81 | 0.017 | |
| positive regulation of protein catabolic process | GO:0045732 | 60 | 0.017 | |
| oocyte development | GO:0048599 | 33 | 0.017 | |
| regulation of homeostatic process | GO:0032844 | 182 | 0.017 | |
| modification by symbiont of host morphology or physiology | GO:0044003 | 4 | 0.017 | |
| ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway | GO:0043162 | 3 | 0.017 | |
| positive regulation of proteolysis | GO:0045862 | 85 | 0.017 | |
| gtp catabolic process | GO:0006184 | 143 | 0.017 | |
| cation transmembrane transport | GO:0098655 | 266 | 0.017 | |
| chromatin modification | GO:0016568 | 187 | 0.017 | |
| extracellular matrix organization | GO:0030198 | 147 | 0.017 | |
| sensory perception | GO:0007600 | 245 | 0.016 | |
| negative regulation of protein processing | GO:0010955 | 79 | 0.016 | |
| regulation of lymphocyte differentiation | GO:0045619 | 107 | 0.016 | |
| heterocycle catabolic process | GO:0046700 | 280 | 0.016 | |
| regulation of histone methylation | GO:0031060 | 30 | 0.016 | |
| epithelial cell development | GO:0002064 | 159 | 0.016 | Fly |
| nucleobase containing compound transport | GO:0015931 | 27 | 0.016 | |
| negative regulation of cellular protein metabolic process | GO:0032269 | 247 | 0.016 | Fly |
| notch signaling pathway | GO:0007219 | 71 | 0.016 | Fly |
| segmentation | GO:0035282 | 93 | 0.016 | |
| regulation of cellular amino acid metabolic process | GO:0006521 | 5 | 0.016 | |
| establishment of protein localization to plasma membrane | GO:0090002 | 34 | 0.016 | |
| positive regulation of protein kinase activity | GO:0045860 | 144 | 0.016 | |
| regulation of lymphocyte activation | GO:0051249 | 240 | 0.016 | |
| behavioral response to nutrient | GO:0051780 | 1 | 0.016 | |
| negative regulation of insulin receptor signaling pathway | GO:0046627 | 14 | 0.016 | |
| cell cycle switching mitotic to meiotic cell cycle | GO:0051728 | 1 | 0.016 | |
| sperm individualization | GO:0007291 | 1 | 0.015 | |
| cellular response to cytokine stimulus | GO:0071345 | 189 | 0.015 | |
| positive regulation of notch signaling pathway | GO:0045747 | 18 | 0.015 | |
| regulation of leukocyte differentiation | GO:1902105 | 159 | 0.015 | |
| positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway | GO:2001269 | 3 | 0.015 | |
| cell junction maintenance | GO:0034331 | 4 | 0.015 | |
| cellular response to dna damage stimulus | GO:0006974 | 207 | 0.015 | |
| spermatid development | GO:0007286 | 108 | 0.015 | |
| translation | GO:0006412 | 93 | 0.015 | |
| regulation of carbohydrate biosynthetic process | GO:0043255 | 40 | 0.014 | |
| myeloid leukocyte differentiation | GO:0002573 | 119 | 0.014 | |
| purine nucleoside triphosphate catabolic process | GO:0009146 | 203 | 0.014 | |
| posttranslational protein targeting to membrane | GO:0006620 | 2 | 0.014 | |
| regulation of cytoplasmic transport | GO:1903649 | 112 | 0.014 | |
| regulation of binding | GO:0051098 | 111 | 0.014 | |
| membrane tubulation | GO:0097320 | 4 | 0.014 | |
| modification dependent protein catabolic process | GO:0019941 | 133 | 0.014 | |
| glycoprotein biosynthetic process | GO:0009101 | 89 | 0.014 | |
| protein localization to membrane | GO:0072657 | 108 | 0.014 | Human |
| oocyte differentiation | GO:0009994 | 35 | 0.014 | |
| regulation of cytoplasmic translation | GO:2000765 | 4 | 0.014 | |
| stem cell development | GO:0048864 | 219 | 0.014 | |
| t cell differentiation in thymus | GO:0033077 | 77 | 0.014 | |
| organelle assembly | GO:0070925 | 177 | 0.014 | |
| t cell activation | GO:0042110 | 289 | 0.014 | |
| positive regulation of cellular catabolic process | GO:0031331 | 148 | 0.013 | |
| learning | GO:0007612 | 98 | 0.013 | |
| regulation of jak stat cascade | GO:0046425 | 34 | 0.013 | Human |
| regulation of cardiac cell fate specification | GO:2000043 | 1 | 0.013 | |
| cerebellar granule cell precursor tangential migration | GO:0021935 | 1 | 0.013 | |
| transition metal ion transport | GO:0000041 | 38 | 0.013 | |
| transmembrane receptor protein serine threonine kinase signaling pathway | GO:0007178 | 194 | 0.013 | |
| anion transport | GO:0006820 | 177 | 0.013 | |
| positive regulation of proteolysis involved in cellular protein catabolic process | GO:1903052 | 31 | 0.013 | |
| circadian rhythm | GO:0007623 | 114 | 0.013 | |
| positive regulation of binding | GO:0051099 | 49 | 0.013 | |
| histone methylation | GO:0016571 | 71 | 0.013 | |
| establishment or maintenance of cytoskeleton polarity | GO:0030952 | 2 | 0.013 | |
| response to nutrient levels | GO:0031667 | 109 | 0.013 | |
| positive regulation of membrane protein ectodomain proteolysis | GO:0051044 | 3 | 0.012 | |
| cellular lipid metabolic process | GO:0044255 | 323 | 0.012 | |
| protein methylation | GO:0006479 | 81 | 0.012 | |
| negative regulation of cell activation | GO:0050866 | 111 | 0.012 | |
| satellite cell activation involved in skeletal muscle regeneration | GO:0014901 | 3 | 0.012 | |
| nuclear transcribed mrna catabolic process | GO:0000956 | 16 | 0.012 | |
| mesodermal cell migration | GO:0008078 | 4 | 0.012 | |
| mitotic cell cycle process | GO:1903047 | 159 | 0.012 | |
| glycosyl compound catabolic process | GO:1901658 | 206 | 0.012 | |
| male gamete generation | GO:0048232 | 285 | 0.012 | |
| fatty acid biosynthetic process | GO:0006633 | 41 | 0.012 | |
| protein maturation | GO:0051604 | 176 | 0.012 | |
| ribonucleotide metabolic process | GO:0009259 | 291 | 0.012 | |
| regulation of intrinsic apoptotic signaling pathway | GO:2001242 | 61 | 0.012 | |
| rhythmic process | GO:0048511 | 174 | 0.012 | |
| negative regulation of mapk cascade | GO:0043409 | 65 | 0.012 | |
| cognition | GO:0050890 | 149 | 0.012 | |
| fibroblast growth factor receptor signaling pathway | GO:0008543 | 46 | 0.012 | Fly |
| regulation of translation | GO:0006417 | 71 | 0.012 | |
| positive regulation of cell activation | GO:0050867 | 158 | 0.012 | |
| negative regulation of proteolysis | GO:0045861 | 74 | 0.012 | |
| nitrogen compound transport | GO:0071705 | 271 | 0.011 | |
| divalent inorganic cation transport | GO:0072511 | 178 | 0.011 | |
| regulation of synaptic growth at neuromuscular junction | GO:0008582 | 4 | 0.011 | |
| posttranscriptional regulation of gene expression | GO:0010608 | 155 | 0.011 | |
| mrna transcription from rna polymerase ii promoter | GO:0042789 | 4 | 0.011 | |
| striated muscle tissue development | GO:0014706 | 293 | 0.011 | |
| ephrin receptor signaling pathway | GO:0048013 | 20 | 0.011 | |
| organic anion transport | GO:0015711 | 137 | 0.011 | |
| mitotic cytokinesis | GO:0000281 | 4 | 0.011 | |
| negative regulation of phosphorus metabolic process | GO:0010563 | 184 | 0.011 | Fly |
| antimicrobial peptide production | GO:0002775 | 2 | 0.011 | |
| ribonucleotide catabolic process | GO:0009261 | 208 | 0.011 | |
| fat cell differentiation | GO:0045444 | 160 | 0.011 | |
| small molecule biosynthetic process | GO:0044283 | 132 | 0.011 | |
| brain segmentation | GO:0035284 | 3 | 0.011 | |
| regulation of t cell activation | GO:0050863 | 170 | 0.011 | |
| cell type specific apoptotic process | GO:0097285 | 268 | 0.011 | |
| mrna metabolic process | GO:0016071 | 84 | 0.011 | |
| nucleotide metabolic process | GO:0009117 | 332 | 0.011 | |
| gonad development | GO:0008406 | 141 | 0.011 | |
| negative regulation of apoptotic signaling pathway | GO:2001234 | 104 | 0.011 | |
| negative regulation of cellular component organization | GO:0051129 | 194 | 0.011 | |
| protein processing | GO:0016485 | 163 | 0.011 | |
| circadian temperature homeostasis | GO:0060086 | 2 | 0.011 | |
| negative regulation of triglyceride biosynthetic process | GO:0010868 | 2 | 0.011 | |
| learning or memory | GO:0007611 | 148 | 0.011 | |
| purine nucleoside metabolic process | GO:0042278 | 241 | 0.011 | |
| negative regulation of epidermal growth factor receptor signaling pathway | GO:0042059 | 6 | 0.010 | Fly |
| cellular response to starvation | GO:0009267 | 57 | 0.010 | |
| carbohydrate transport | GO:0008643 | 62 | 0.010 | |
| nucleoside phosphate metabolic process | GO:0006753 | 338 | 0.010 | |
| regulation of chromatin modification | GO:1903308 | 57 | 0.010 | |
| negative regulation of intrinsic apoptotic signaling pathway | GO:2001243 | 34 | 0.010 | |
| regulation of apoptotic signaling pathway | GO:2001233 | 197 | 0.010 | |
| glucose metabolic process | GO:0006006 | 92 | 0.010 | |
| regulation of secretion | GO:0051046 | 274 | 0.010 | Human |
| positive regulation of ran gtpase activity | GO:0032853 | 3 | 0.010 | |
| regulation of membrane protein ectodomain proteolysis | GO:0051043 | 3 | 0.010 | |
| purine ribonucleoside triphosphate catabolic process | GO:0009207 | 199 | 0.010 | |
| insulin receptor signaling pathway | GO:0008286 | 49 | 0.010 | |
| leukocyte proliferation | GO:0070661 | 172 | 0.010 | |
| early endosome to late endosome transport | GO:0045022 | 2 | 0.010 | |
| purine ribonucleoside metabolic process | GO:0046128 | 241 | 0.010 | |
