Mus musculus

45 known processes

Top2b

topoisomerase (DNA) II beta

(Aliases: D230016L12Rik,Top-2)

Top2b biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
oocyte constructionGO:000730820.215
regulation of cytoskeleton organizationGO:00514931220.162
gonad developmentGO:00084061410.153
microtubule cytoskeleton organizationGO:00002261570.148
Fly
regulation of organelle organizationGO:00330432890.124
mitotic nuclear divisionGO:0007067480.106
Fly
dna metabolic processGO:00062593030.105
Human Yeast Mouse Fly
chromatin assembly or disassemblyGO:0006333160.099
Yeast
myeloid cell homeostasisGO:00022621140.099
regulation of actin cytoskeleton organizationGO:0032956840.098
nuclear divisionGO:00002801580.097
Yeast Fly
cell divisionGO:00513011200.093
Mouse
peptidyl amino acid modificationGO:00181933360.086
regulation of cellular component biogenesisGO:00440871810.082
cellular response to dna damage stimulusGO:00069742070.081
Fly
oocyte axis specificationGO:000730920.080
cell adhesionGO:00071553290.071
regulation of chromosome organizationGO:0033044830.070
positive regulation of mitotic sister chromatid separationGO:190197020.069
response to molecule of bacterial originGO:00022371430.066
histone modificationGO:00165701590.066
natural killer cell differentiationGO:0001779210.063
chromosome segregationGO:0007059480.061
Mouse Fly
regulation of neuron differentiationGO:00456642810.060
regulation of cell activationGO:00508652890.056
regulation of cell morphogenesis involved in differentiationGO:00107691510.056
regulation of cell cycleGO:00517262810.056
Yeast Fly
development of primary sexual characteristicsGO:00451371430.055
chemotaxisGO:00069352470.054
Zebrafish
axon guidanceGO:00074111410.053
Zebrafish
germ cell developmentGO:00072811850.052
gene silencingGO:0016458380.052
Worm Fly
neuron projection guidanceGO:00974851410.052
Zebrafish
inorganic cation transmembrane transportGO:00986622070.051
mrna metabolic processGO:0016071840.050
positive regulation of neuron differentiationGO:00456661410.047
neuron projection extensionGO:1990138640.046
rhythmic processGO:00485111740.046
small gtpase mediated signal transductionGO:0007264970.045
multi organism reproductive behaviorGO:0044705290.045
cellular nitrogen compound catabolic processGO:00442702800.045
Human Yeast Mouse Fly
protein dna complex subunit organizationGO:0071824280.045
negative regulation of nervous system developmentGO:00519611560.044
natural killer cell activationGO:0030101440.043
regulation of cell substrate adhesionGO:0010810730.042
regulation of cellular amino acid metabolic processGO:000652150.041
protein digestionGO:004425610.041
covalent chromatin modificationGO:00165691630.040
meiotic nuclear divisionGO:00071261150.039
Yeast
organelle localizationGO:00516401790.038
Fly
spindle assembly involved in meiosisGO:009030640.038
regulation of mrna splicing via spliceosomeGO:0048024320.038
macromolecule catabolic processGO:00090572810.038
multi multicellular organism processGO:00447061090.037
positive regulation of cell developmentGO:00107202370.036
endocytosisGO:00068971680.036
regulation of apoptotic signaling pathwayGO:20012331970.035
regulation of mitotic sister chromatid segregationGO:0033047120.033
cell growthGO:00160491300.033
muscle cell differentiationGO:00426922610.033
nucleus localizationGO:0051647200.032
protein polymerizationGO:0051258570.032
mitotic cell cycleGO:00002781950.032
Yeast Fly
cellular lipid metabolic processGO:00442553230.032
organic hydroxy compound metabolic processGO:19016152030.032
metaphase plate congressionGO:005131020.031
Fly
regulation of sister chromatid segregationGO:0033045130.031
regulation of cell cycle processGO:00105641600.031
Yeast Fly
response to lipopolysaccharideGO:00324961280.031
microtubule nucleationGO:000702020.030
protein oligomerizationGO:0051259670.030
regulation of neuron projection developmentGO:00109751690.030
male gamete generationGO:00482322850.029
regulation of cellular catabolic processGO:00313292420.029
organophosphate catabolic processGO:00464342320.029
Human Yeast Mouse Fly
ras protein signal transductionGO:0007265770.028
cellular response to transforming growth factor beta stimulusGO:0071560880.028
developmental growth involved in morphogenesisGO:00605601380.028
establishment or maintenance of cell polarityGO:0007163860.028
protein ubiquitinationGO:00165671710.028
regulation of neural precursor cell proliferationGO:2000177700.028
negative regulation of protein depolymerizationGO:1901880210.028
multicellular organismal macromolecule catabolic processGO:004426610.028
lymphocyte differentiationGO:00300982420.027
maintenance of locationGO:0051235890.027
body morphogenesisGO:0010171450.027
actin filament organizationGO:00070151130.027
aromatic compound catabolic processGO:00194392860.026
Human Yeast Mouse Fly
regulation of cellular ketone metabolic processGO:0010565660.026
epithelial cell developmentGO:00020641590.026
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.026
positive regulation of organelle organizationGO:00106381280.026
negative regulation of cell proliferationGO:00082852960.026
development of primary female sexual characteristicsGO:0046545730.025
nucleoside phosphate catabolic processGO:19012922220.025
Human Yeast Mouse Fly
t cell activationGO:00421102890.025
erythrocyte differentiationGO:0030218880.025
female gamete generationGO:0007292740.025
mitotic sister chromatid cohesionGO:000706410.025
microtubule based processGO:00070172360.025
Fly
stem cell differentiationGO:00488632680.025
ovarian follicle developmentGO:0001541400.025
negative regulation of chromatin silencingGO:003193610.024
regulation of actin polymerization or depolymerizationGO:0008064450.024
mitochondrion distributionGO:004831140.024
mitotic sister chromatid segregationGO:0000070140.024
Fly
cellular amino acid metabolic processGO:00065201030.024
compound eye developmentGO:004874910.024
negative regulation of synapse assemblyGO:005196430.024
response to insulinGO:00328681000.024
epithelial cell proliferationGO:00506731740.023
organic cyclic compound catabolic processGO:19013612950.023
Human Yeast Mouse Fly
histone h3 k4 trimethylationGO:008018250.023
neural tube developmentGO:00219151600.022
glycosyl compound metabolic processGO:19016572460.022
Human Yeast Mouse Fly
blastocyst developmentGO:0001824800.022
ossificationGO:00015032160.022
cellular amine metabolic processGO:0044106440.022
positive regulation of gtpase activityGO:0043547850.022
cellular ketone metabolic processGO:0042180840.022
regulation of b cell activationGO:0050864810.021
circulatory system processGO:00030131970.021
nitrogen compound transportGO:00717052710.021
spermatogenesisGO:00072832840.021
centrosome cycleGO:0007098230.021
regulation of system processGO:00440572000.020
spindle assembly involved in female meiosis iGO:000705720.020
intracellular mrna localizationGO:000829840.020
regulation of mapk cascadeGO:00434082480.020
positive regulation of mapk cascadeGO:00434101700.020
regulation of epithelial cell proliferationGO:00506781410.020
microtubule polymerization or depolymerizationGO:0031109260.020
positive regulation of gtp catabolic processGO:0033126850.020
regulation of cellular component sizeGO:00325351210.020
regulation of protein localizationGO:00328802310.020
leukocyte differentiationGO:00025213420.020
transforming growth factor beta receptor signaling pathwayGO:0007179710.019
digestive tract developmentGO:00485651900.019
leukocyte migrationGO:00509001240.019
chromatin organizationGO:00063252060.019
Yeast
regulation of cellular response to stressGO:00801351590.019
mrna processingGO:0006397630.019
cytokine productionGO:00018163190.019
cellular response to insulin stimulusGO:0032869780.019
female gonad developmentGO:0008585710.019
ribonucleoside triphosphate catabolic processGO:00092031990.018
Human Yeast Mouse Fly
positive regulation of cellular amine metabolic processGO:003324050.018
female sex differentiationGO:0046660840.018
regulation of rna splicingGO:0043484370.018
chromatin modificationGO:00165681870.018
Yeast
positive regulation of protein phosphorylationGO:00019342420.017
leukocyte proliferationGO:00706611720.017
regulation of b cell differentiationGO:0045577230.017
peptidyl lysine trimethylationGO:0018023120.017
cell fate commitmentGO:00451652100.017
regulation of ras protein signal transductionGO:00465781140.017
regulation of neurotransmitter levelsGO:0001505870.017
protein catabolic processGO:00301632210.017
mrna localization resulting in posttranscriptional regulation of gene expressionGO:001060920.017
peptidyl lysine modificationGO:0018205770.017
regulation of mrna processingGO:0050684410.017
cell matrix adhesionGO:0007160680.017
phagocytosisGO:0006909660.016
establishment of organelle localizationGO:00516561220.016
Fly
negative regulation of rna splicingGO:0033119120.016
carbohydrate derivative catabolic processGO:19011362310.016
Human Yeast Mouse Fly
mapk cascadeGO:00001652810.016
dendrite developmentGO:00163581150.016
regulation of leukocyte differentiationGO:19021051590.016
protein modification by small protein conjugationGO:00324461870.016
embryonic limb morphogenesisGO:00303261260.016
response to organonitrogen compoundGO:00102432460.016
peyer s patch developmentGO:0048541120.016
ribonucleoprotein complex subunit organizationGO:0071826280.016
single organism cell adhesionGO:00986021560.016
mrna transportGO:0051028130.015
mesoderm developmentGO:00074981000.015
negative regulation of immune system processGO:00026832090.015
negative regulation of gene expression epigeneticGO:0045814150.015
Fly
t cell differentiationGO:00302171740.015
homeostasis of number of cellsGO:00488722100.015
positive regulation of cell cycle processGO:0090068610.015
blood circulationGO:00080151950.015
regulation of mitotic cell cycleGO:00073461260.015
Yeast Fly
positive regulation of protein modification processGO:00314012990.015
organelle assemblyGO:00709251770.015
b cell proliferationGO:0042100530.015
photoreceptor cell developmentGO:0042461400.015
positive regulation of nervous system developmentGO:00519622210.015
regulation of mitosisGO:0007088290.014
positive regulation of glucose metabolic processGO:0010907210.014
negative regulation of apoptotic signaling pathwayGO:20012341040.014
megakaryocyte differentiationGO:0030219260.014
regulation of neuron apoptotic processGO:00435231220.014
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathwayGO:004316230.014
cellular polysaccharide metabolic processGO:0044264380.014
cation transmembrane transportGO:00986552660.014
negative regulation of organelle organizationGO:0010639900.014
neuroblast differentiationGO:001401620.014
developmental maturationGO:00217001930.014
regulation of cytokine productionGO:00018172660.014
response to peptide hormoneGO:00434341270.014
regulation of chromosome segregationGO:0051983210.014
regulation of leukocyte proliferationGO:00706631210.013
lateral mesodermal cell fate commitmentGO:004837220.013
actin polymerization or depolymerizationGO:0008154540.013
regulation of microtubule cytoskeleton organizationGO:0070507370.013
blastocyst formationGO:0001825330.013
oocyte differentiationGO:0009994350.013
formation of primary germ layerGO:0001704770.013
ovulation cycleGO:0042698590.013
liver developmentGO:0001889660.013
centrosome organizationGO:0051297260.013
nucleoside catabolic processGO:00091642060.013
Human Yeast Mouse Fly
meiotic cell cycle processGO:1903046770.013
Yeast
spindle assembly involved in female meiosisGO:000705630.013
sperm individualizationGO:000729110.013
multicellular organismal reproductive behaviorGO:0033057230.013
dna dependent dna replicationGO:0006261240.013
Yeast
oocyte developmentGO:0048599330.013
nucleoside triphosphate metabolic processGO:00091412300.013
Human Yeast Mouse Fly
hindbrain developmentGO:00309021280.013
apoptotic signaling pathwayGO:00971903060.013
spermatid developmentGO:00072861080.013
b cell differentiationGO:0030183780.013
regulation of cell growthGO:0001558910.012
regulation of cellular amine metabolic processGO:0033238200.012
stem cell maintenanceGO:00198271300.012
mitotic cytokinesisGO:000028140.012
response to growth factorGO:00708481980.012
protein polyubiquitinationGO:0000209330.012
modification dependent macromolecule catabolic processGO:00436321330.012
regulation of microtubule polymerization or depolymerizationGO:0031110200.012
mrna destabilizationGO:006115740.012
regulation of gtp catabolic processGO:00331241130.012
ribonucleoside catabolic processGO:00424542060.012
Human Yeast Mouse Fly
calcium ion transportGO:00068161590.012
regulation of synaptic growth at neuromuscular junctionGO:000858240.012
regulation of actin filament based processGO:0032970990.012
cellularizationGO:000734910.012
regulation of cell shapeGO:0008360390.012
protein localization to organelleGO:00333651850.012
regulation of protein depolymerizationGO:1901879260.012
cellular protein catabolic processGO:00442571550.012
microtubule organizing center organizationGO:0031023280.012
protein modification by small protein conjugation or removalGO:00706472070.012
mitotic sister chromatid separationGO:005130690.011
positive regulation of growthGO:00459271040.011
digestive system developmentGO:00551232000.011
posttranscriptional regulation of gene expressionGO:00106081550.011
Worm
macromolecule methylationGO:00434141200.011
purine ribonucleoside catabolic processGO:00461302050.011
Human Yeast Mouse Fly
purine ribonucleotide catabolic processGO:00091542080.011
Human Yeast Mouse Fly
positive regulation of lymphocyte activationGO:00512511400.011
cerebellum developmentGO:0021549770.011
negative regulation of t cell proliferationGO:0042130380.011
ribonucleotide catabolic processGO:00092612080.011
Human Yeast Mouse Fly
cellular macromolecule catabolic processGO:00442652060.011
regulation of rna stabilityGO:0043487260.011
neural precursor cell proliferationGO:00613511210.011
positive regulation of chromosome segregationGO:005198440.011
positive regulation of cellular catabolic processGO:00313311480.011
regulation of cellular response to hypoxiaGO:190003720.011
regulation of t cell proliferationGO:0042129920.011
digestive tract morphogenesisGO:00485461470.011
myeloid cell differentiationGO:00300992330.011
glycosyl compound catabolic processGO:19016582060.011
Human Yeast Mouse Fly
circadian rhythmGO:00076231140.011
regulation of cell projection organizationGO:00313442060.011
purine ribonucleoside metabolic processGO:00461282410.011
Human Yeast Mouse Fly
multi organism behaviorGO:0051705620.011
regulation of translationGO:0006417710.010
protein acylationGO:0043543640.010
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.010
positive regulation of cell activationGO:00508671580.010
leukocyte tethering or rollingGO:005090130.010
positive regulation of transferase activityGO:00513471670.010
meiotic spindle organizationGO:000021290.010
cation transportGO:00068123990.010
regulation of cardiac cell fate specificationGO:200004310.010
negative regulation of cell activationGO:00508661110.010
negative regulation of hepatocyte proliferationGO:200034630.010
histone h3 k4 methylationGO:0051568230.010

Top2b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.245
nervous system diseaseDOID:86300.245
central nervous system diseaseDOID:33100.115
neurodegenerative diseaseDOID:128900.075
sensory system diseaseDOID:005015500.058
eye and adnexa diseaseDOID:149200.038
eye diseaseDOID:561400.023
x linked diseaseDOID:005073500.010
endocrine gland cancerDOID:17000.010
cancerDOID:16200.010
disease of cellular proliferationDOID:1456600.010
organ system cancerDOID:005068600.010