Mus musculus

107 known processes

Psme4

proteasome (prosome, macropain) activator subunit 4

(Aliases: TEMO,AU041366,KIAA0077,AA409398,mKIAA0077)

Psme4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
proteolysis involved in cellular protein catabolic processGO:00516031470.603
macromolecule catabolic processGO:00090572810.537
modification dependent protein catabolic processGO:00199411330.419
modification dependent macromolecule catabolic processGO:00436321330.393
cellular macromolecule catabolic processGO:00442652060.369
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.342
regulation of cellular catabolic processGO:00313292420.277
cellular protein catabolic processGO:00442571550.270
proteasomal protein catabolic processGO:0010498980.207
positive regulation of cellular catabolic processGO:00313311480.180
regulation of translationGO:0006417710.177
posttranscriptional regulation of gene expressionGO:00106081550.154
mitotic cell cycleGO:00002781950.153
translationGO:0006412930.145
ubiquitin dependent protein catabolic processGO:00065111290.138
protein catabolic processGO:00301632210.109
purine containing compound metabolic processGO:00725213110.103
protein modification by small protein removalGO:0070646210.101
carbohydrate derivative catabolic processGO:19011362310.090
ribose phosphate metabolic processGO:00196932910.087
nucleoside phosphate metabolic processGO:00067533380.086
nucleotide catabolic processGO:00091662170.084
gtp metabolic processGO:00460391440.081
nucleoside triphosphate catabolic processGO:00091432050.079
protein modification by small protein conjugationGO:00324461870.077
regulation of proteolysis involved in cellular protein catabolic processGO:1903050560.076
ras protein signal transductionGO:0007265770.076
organic cyclic compound catabolic processGO:19013612950.075
protein modification by small protein conjugation or removalGO:00706472070.073
purine ribonucleotide metabolic processGO:00091502900.073
lipid localizationGO:00108761260.071
guanosine containing compound metabolic processGO:19010681440.070
purine ribonucleoside catabolic processGO:00461302050.066
purine nucleoside triphosphate metabolic processGO:00091442260.065
membrane organizationGO:00610242450.063
small gtpase mediated signal transductionGO:0007264970.061
endomembrane system organizationGO:00102561470.061
purine nucleotide catabolic processGO:00061952110.061
purine nucleoside metabolic processGO:00422782410.060
positive regulation of proteolysis involved in cellular protein catabolic processGO:1903052310.060
nucleotide metabolic processGO:00091173320.060
regulation of nucleoside metabolic processGO:00091181300.055
nucleoside triphosphate metabolic processGO:00091412300.055
purine nucleoside catabolic processGO:00061522050.052
negative regulation of cellular protein metabolic processGO:00322692470.051
cellular nitrogen compound catabolic processGO:00442702800.050
purine ribonucleoside triphosphate metabolic processGO:00092052200.049
regulation of cell cycleGO:00517262810.049
positive regulation of gtpase activityGO:0043547850.049
nucleoside metabolic processGO:00091162460.049
tissue migrationGO:0090130680.047
organophosphate catabolic processGO:00464342320.046
purine ribonucleotide catabolic processGO:00091542080.046
regulation of hydrolase activityGO:00513362460.046
purine nucleotide metabolic processGO:00061633020.045
regulation of organelle organizationGO:00330432890.044
glycosyl compound metabolic processGO:19016572460.044
purine nucleoside triphosphate catabolic processGO:00091462030.043
regulation of nucleotide metabolic processGO:00061401690.043
maintenance of locationGO:0051235890.042
intracellular steroid hormone receptor signaling pathwayGO:0030518290.042
organonitrogen compound catabolic processGO:19015652640.041
regulation of ras gtpase activityGO:0032318880.041
ribonucleotide catabolic processGO:00092612080.041
purine ribonucleoside metabolic processGO:00461282410.040
nucleobase containing small molecule metabolic processGO:00550863520.040
aromatic compound catabolic processGO:00194392860.040
positive regulation of purine nucleotide catabolic processGO:0033123880.039
ribonucleoside triphosphate catabolic processGO:00092031990.039
regulation of gtp catabolic processGO:00331241130.039
cellular homeostasisGO:00197252400.038
ribonucleotide metabolic processGO:00092592910.037
actin cytoskeleton organizationGO:00300362200.037
intracellular protein transportGO:00068862040.037
regulation of proteasomal protein catabolic processGO:0061136460.037
cellular amine metabolic processGO:0044106440.036
heterocycle catabolic processGO:00467002800.035
ribonucleoside metabolic processGO:00091192450.035
er associated ubiquitin dependent protein catabolic processGO:0030433100.035
ribonucleoside catabolic processGO:00424542060.035
purine ribonucleoside triphosphate catabolic processGO:00092071990.035
purine containing compound catabolic processGO:00725232130.034
regulation of nucleotide catabolic processGO:00308111220.034
rho protein signal transductionGO:0007266320.034
negative regulation of protein metabolic processGO:00512482820.034
axonogenesisGO:00074092740.033
mitochondrion organizationGO:00070051340.032
regulation of anatomical structure sizeGO:00900661780.032
cellular amino acid metabolic processGO:00065201030.031
protein oligomerizationGO:0051259670.031
adult behaviorGO:00305341350.030
digestive tract morphogenesisGO:00485461470.030
multicellular organismal homeostasisGO:00488711640.030
multicellular organismal macromolecule catabolic processGO:004426610.030
regulation of ras protein signal transductionGO:00465781140.030
positive regulation of purine nucleotide metabolic processGO:19005441140.029
negative regulation of intracellular signal transductionGO:19025321670.029
nitrogen compound transportGO:00717052710.029
lateral inhibitionGO:004633110.029
cellular response to dna damage stimulusGO:00069742070.028
gtp catabolic processGO:00061841430.028
regulation of mitotic cell cycleGO:00073461260.027
positive regulation of nucleotide catabolic processGO:0030813880.027
tube closureGO:0060606910.027
spermatogenesisGO:00072832840.027
protein processingGO:00164851630.027
protein deubiquitinationGO:0016579190.027
regulation of purine nucleotide metabolic processGO:19005421690.026
positive regulation of cellular component biogenesisGO:0044089940.026
negative regulation of apoptotic signaling pathwayGO:20012341040.026
male gamete generationGO:00482322850.026
protein localization to organelleGO:00333651850.025
regulation of protein catabolic processGO:00421761080.025
positive regulation of cellular protein catabolic processGO:1903364340.025
amine metabolic processGO:0009308450.025
cytoplasmic transportGO:00164822340.025
ribonucleoside triphosphate metabolic processGO:00091992200.025
ion transmembrane transportGO:00342203610.025
protein polyubiquitinationGO:0000209330.025
cellular protein complex assemblyGO:00436231160.024
neural tube developmentGO:00219151600.024
cell type specific apoptotic processGO:00972852680.024
engulfment of apoptotic cellGO:004365230.024
transmembrane transportGO:00550854120.023
regulation of cell cycle processGO:00105641600.023
nucleoside phosphate catabolic processGO:19012922220.023
dna metabolic processGO:00062593030.023
plasma membrane organizationGO:0007009900.023
neural tube closureGO:0001843900.023
spermatid differentiationGO:00485151150.023
neural tube formationGO:00018411080.023
regulation of cell motilityGO:20001452360.023
positive regulation of nucleoside metabolic processGO:0045979910.023
action potentialGO:0001508780.022
neuronal action potentialGO:0019228540.022
urogenital system developmentGO:00016552610.022
sensory organ morphogenesisGO:00905962420.022
transmission of nerve impulseGO:0019226760.022
forebrain developmentGO:00309003020.021
negative regulation of cellular component organizationGO:00511291940.021
nucleoside catabolic processGO:00091642060.021
regulation of mitotic cell cycle phase transitionGO:1901990730.021
meiosis iGO:0007127600.021
homeostasis of number of cellsGO:00488722100.021
multicellular organismal protein metabolic processGO:004426820.021
cell substrate adhesionGO:00315891300.021
positive regulation of protein catabolic processGO:0045732600.021
regulation of purine nucleotide catabolic processGO:00331211220.021
negative regulation of cell cycleGO:00457861230.021
response to transforming growth factor betaGO:0071559880.021
ribonucleoside monophosphate metabolic processGO:0009161800.020
positive regulation of nucleotide metabolic processGO:00459811140.020
regulation of transmembrane transportGO:00347621280.020
positive regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032436230.020
regulation of cell migrationGO:00303342190.020
cytoskeleton dependent intracellular transportGO:0030705500.020
cellular ion homeostasisGO:00068731650.020
multicellular organismal agingGO:0010259240.020
response to growth factorGO:00708481980.020
epithelial cell migrationGO:0010631630.020
negative regulation of neuron apoptotic processGO:0043524920.020
regulation of protein maturationGO:1903317960.020
digestive tract developmentGO:00485651900.020
regulation of proteolysisGO:00301621640.019
cellular lipid metabolic processGO:00442553230.019
negative regulation of protein modification processGO:00314001630.019
striated muscle myosin thick filament assemblyGO:007168810.019
cellular response to organonitrogen compoundGO:00714171450.019
regulation of membrane potentialGO:00423911920.019
protein ubiquitinationGO:00165671710.019
guanosine containing compound catabolic processGO:19010691440.019
protein maturationGO:00516041760.018
positive regulation of gtp catabolic processGO:0033126850.018
regulation of cell activationGO:00508652890.018
morphogenesis of embryonic epitheliumGO:00163311590.018
anatomical structure homeostasisGO:00602491450.018
positive regulation of cellular amine metabolic processGO:003324050.018
jnk cascadeGO:0007254720.018
regulation of cellular ketone metabolic processGO:0010565660.018
cellular response to transforming growth factor beta stimulusGO:0071560880.018
positive regulation of organelle organizationGO:00106381280.018
camera type eye developmentGO:00430102660.018
purine ribonucleoside monophosphate metabolic processGO:0009167800.018
epithelial tube morphogenesisGO:00605623030.018
dna repairGO:00062811070.018
leukocyte migrationGO:00509001240.018
double strand break repairGO:0006302480.018
negative regulation of protein processingGO:0010955790.018
meiotic cell cycle processGO:1903046770.018
metencephalon developmentGO:0022037890.018
regulation of cellular amine metabolic processGO:0033238200.018
cellular component assembly involved in morphogenesisGO:00109271390.018
cellular response to hormone stimulusGO:00328701500.018
positive regulation of ras gtpase activityGO:0032320650.017
cation transportGO:00068123990.017
regulation of protein localizationGO:00328802310.017
chromosome segregationGO:0007059480.017
cellular response to lipidGO:00713961450.017
phagocytosisGO:0006909660.017
regulation of cellular component biogenesisGO:00440871810.017
tissue homeostasisGO:00018941150.017
gastrulationGO:00073691160.017
mitochondrion distributionGO:004831140.017
intracellular receptor signaling pathwayGO:0030522740.017
renal system developmentGO:00720012250.017
regulation of cellular amino acid metabolic processGO:000652150.017
positive regulation of hydrolase activityGO:00513451480.017
regulation of cellular component sizeGO:00325351210.017
innate immune responseGO:00450871570.017
hindbrain developmentGO:00309021280.016
positive regulation of proteolysisGO:0045862850.016
nucleoside monophosphate metabolic processGO:0009123850.016
establishment of protein localization to organelleGO:00725941180.016
neuron apoptotic processGO:00514021420.016
microtubule cytoskeleton organizationGO:00002261570.016
response to peptideGO:19016521360.016
cellular response to growth factor stimulusGO:00713631970.016
regulation of chromosome organizationGO:0033044830.016
development of primary sexual characteristicsGO:00451371430.016
germ cell developmentGO:00072811850.016
negative regulation of molecular functionGO:00440922580.016
protein targetingGO:00066051430.016
chemotaxisGO:00069352470.016
negative regulation of phosphate metabolic processGO:00459361840.016
glycoprotein metabolic processGO:00091001160.016
negative regulation of mitotic cell cycle phase transitionGO:1901991450.016
vesicle coatingGO:000690120.016
cell adhesionGO:00071553290.016
embryonic epithelial tube formationGO:00018381300.016
response to light stimulusGO:00094161350.015
cation transmembrane transportGO:00986552660.015
skeletal muscle organ developmentGO:00605381630.015
cajal body organizationGO:003057610.015
positive regulation of cellular amino acid metabolic processGO:004576430.015
regulation of establishment of protein localizationGO:00702011810.015
cyclin catabolic processGO:000805410.015
cell divisionGO:00513011200.015
organelle disassemblyGO:190300820.015
muscle tissue developmentGO:00605373080.015
purine nucleoside monophosphate catabolic processGO:0009128580.015
epithelial cell developmentGO:00020641590.015
muscle cell differentiationGO:00426922610.015
single organismal cell cell adhesionGO:00163371310.015
mitotic cytokinesisGO:000028140.015
cerebellum developmentGO:0021549770.015
regulation of actin filament based processGO:0032970990.015
regulation of metal ion transportGO:00109591060.015
tube formationGO:00351481400.015
metal ion homeostasisGO:00550651890.015
gonad developmentGO:00084061410.015
negative regulation of phosphorylationGO:00423261660.015
coenzyme metabolic processGO:0006732520.015
multicellular organismal signalingGO:0035637910.014
cellular ketone metabolic processGO:0042180840.014
microtubule based processGO:00070172360.014
regulation of transferase activityGO:00513382630.014
protein localization to membraneGO:00726571080.014
organelle fissionGO:00482851700.014
regionalizationGO:00030023370.014
regulation of defense responseGO:00313472330.014
myosin filament organizationGO:003103330.014
intrinsic apoptotic signaling pathwayGO:00971931320.014
establishment or maintenance of cell polarityGO:0007163860.013
negative regulation of protein maturationGO:1903318790.013
neuron deathGO:00709971540.013
regulation of translational initiationGO:0006446150.013
inorganic cation transmembrane transportGO:00986622070.013
t cell activationGO:00421102890.013
striated muscle tissue developmentGO:00147062930.013
negative regulation of proteolysisGO:0045861740.013
negative regulation of intrinsic apoptotic signaling pathwayGO:2001243340.013
nuclear importGO:0051170950.013
compound eye developmentGO:004874910.013
microtubule severingGO:005101350.013
eye photoreceptor cell differentiationGO:0001754410.013
ameboidal type cell migrationGO:00016671280.013
negative regulation of mitotic cell cycleGO:0045930580.013
negative regulation of dna replicationGO:000815640.013
rhythmic processGO:00485111740.013
cellular response to peptide hormone stimulusGO:0071375920.013
protein import into nucleusGO:0006606950.013
myosin filament assemblyGO:003103420.013
regulation of ion transportGO:00432692150.013
response to radiationGO:00093141650.013
single organism nuclear importGO:1902593950.012
mitotic cell cycle processGO:19030471590.012
negative regulation of protein phosphorylationGO:00019331260.012
endocytosisGO:00068971680.012
negative regulation of immune system processGO:00026832090.012
multicellular organismal protein catabolic processGO:004425410.012
locomotory behaviorGO:00076261950.012
organelle assemblyGO:00709251770.012
apoptotic signaling pathwayGO:00971903060.012
regulation of protein processingGO:0070613960.012
digestive system developmentGO:00551232000.012
carbohydrate metabolic processGO:00059752300.012
sequestering of calcium ionGO:0051208180.012
single organism cell adhesionGO:00986021560.012
developmental growth involved in morphogenesisGO:00605601380.012
cilium assemblyGO:0042384810.012
gene silencing by rnaGO:0031047190.012
stress activated mapk cascadeGO:0051403800.012
microtubule based transportGO:0010970500.012
cation homeostasisGO:00550802120.012
regulation of cellular protein catabolic processGO:1903362610.012
amide transportGO:00428861380.012
cellular response to cytokine stimulusGO:00713451890.012
regulation of t cell activationGO:00508631700.012
regulation of cell cycle phase transitionGO:1901987770.012
negative regulation of cell proliferationGO:00082852960.012
myelinationGO:0042552740.012
cellular response to peptideGO:1901653920.012
dendrite developmentGO:00163581150.012
regulation of neuron apoptotic processGO:00435231220.012
stress activated protein kinase signaling cascadeGO:0031098810.011
bmp signaling pathwayGO:0030509930.011
inorganic ion transmembrane transportGO:00986602340.011
negative regulation of cellular catabolic processGO:0031330470.011
gene silencingGO:0016458380.011
regulation of protein complex assemblyGO:0043254830.011
limb developmentGO:00601731660.011
epithelial cell proliferationGO:00506731740.011
blastocyst developmentGO:0001824800.011
chromatin organizationGO:00063252060.011
epithelial tube formationGO:00721751300.011
regulation of protein oligomerizationGO:003245940.011
translational initiationGO:0006413240.011
transforming growth factor beta receptor signaling pathwayGO:0007179710.011
nucleus organizationGO:0006997450.011
positive regulation of cell motilityGO:20001471160.011
localization within membraneGO:005166840.011
nuclear transportGO:00511691390.011
negative regulation of cell cycle processGO:0010948690.011
regulation of secretionGO:00510462740.011
glycoprotein biosynthetic processGO:0009101890.011
regulation of stress activated mapk cascadeGO:0032872690.011
response to insulinGO:00328681000.011
protein homooligomerizationGO:0051260430.011
protein digestionGO:004425610.011
determination of adult lifespanGO:0008340110.011
stem cell differentiationGO:00488632680.011
cytokinetic processGO:003250620.011
negative regulation of nervous system developmentGO:00519611560.011
lipid storageGO:0019915360.011
nucleoside monophosphate catabolic processGO:0009125590.011
regulation of ion transmembrane transportGO:00347651190.011
regulation of neuron deathGO:19012141340.011
adult locomotory behaviorGO:0008344910.011
protein importGO:00170381010.011
positive regulation of growthGO:00459271040.010
phospholipid metabolic processGO:0006644870.010
regulation of homeostatic processGO:00328441820.010
ribonucleoprotein complex disassemblyGO:003298830.010
gliogenesisGO:00420631410.010
wnt signaling pathwayGO:00160551880.010
spermatid developmentGO:00072861080.010
metaphase plate congressionGO:005131020.010
divalent metal ion transportGO:00708381720.010
response to lipopolysaccharideGO:00324961280.010

Psme4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
amino acid metabolic disorderDOID:925200.022
inherited metabolic disorderDOID:65500.022
disease of metabolismDOID:001466700.022
organic acidemiaDOID:006015900.022
disease of cellular proliferationDOID:1456600.017
musculoskeletal system diseaseDOID:1700.016
disease of anatomical entityDOID:700.016
organ system cancerDOID:005068600.015
cancerDOID:16200.015
nervous system diseaseDOID:86300.014
muscular diseaseDOID:008000000.014
immune system diseaseDOID:291400.011