Mus musculus

226 known processes

Irak1

interleukin-1 receptor-associated kinase 1

(Aliases: IRAK,Plpk,IRAK1-S,AA408924,Il1rak,IRAK-1,mPLK)

Irak1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
immune response activating signal transductionGO:00027571160.391
cytokine productionGO:00018163190.344
Mouse
protein polyubiquitinationGO:0000209330.276
innate immune response activating signal transductionGO:0002758500.244
type i interferon productionGO:0032606290.240
positive regulation of defense responseGO:00313491240.234
activation of innate immune responseGO:0002218560.208
regulation of defense responseGO:00313472330.202
activation of nf kappab inducing kinase activityGO:000725040.167
Human
regulation of nucleotide binding oligomerization domain containing 1 signaling pathwayGO:007042830.162
immune response regulating signaling pathwayGO:00027641250.156
cellular amine metabolic processGO:0044106440.152
cytoplasmic pattern recognition receptor signaling pathwayGO:0002753100.150
pattern recognition receptor signaling pathwayGO:0002221470.129
positive regulation of mapk cascadeGO:00434101700.122
negative regulation of cytokine productionGO:0001818840.120
Mouse
activation of immune responseGO:00022531380.119
cytokine mediated signaling pathwayGO:00192211150.118
response to molecule of fungal originGO:000223840.111
positive regulation of protein modification processGO:00314012990.108
regulation of innate immune responseGO:0045088910.107
regulation of cytokine production involved in immune responseGO:0002718260.101
Mouse
positive regulation of innate immune responseGO:0045089800.094
mapk cascadeGO:00001652810.094
nucleotide binding oligomerization domain containing signaling pathwayGO:007042360.093
protein ubiquitinationGO:00165671710.091
intracellular receptor signaling pathwayGO:0030522740.090
regulation of nucleotide binding oligomerization domain containing signaling pathwayGO:007042430.086
regulation of cell activationGO:00508652890.083
regulation of cellular response to stressGO:00801351590.082
regulation of cellular amino acid metabolic processGO:000652150.080
interleukin 1 mediated signaling pathwayGO:007049840.080
i kappab kinase nf kappab signalingGO:0007249850.079
Human
negative regulation of immune system processGO:00026832090.077
Mouse
positive regulation of protein phosphorylationGO:00019342420.077
cellular amino acid metabolic processGO:00065201030.076
defense response to bacteriumGO:00427421190.075
regulation of type i interferon productionGO:0032479220.075
response to lipopolysaccharideGO:00324961280.069
interleukin 18 mediated signaling pathwayGO:003565520.069
apoptotic signaling pathwayGO:00971903060.068
regulation of jnk cascadeGO:0046328620.066
peptidyl amino acid modificationGO:00181933360.064
negative regulation of ripoptosome assembly involved in necroptotic processGO:190244330.061
cellular ketone metabolic processGO:0042180840.060
stress activated mapk cascadeGO:0051403800.060
negative regulation of interleukin 6 productionGO:0032715170.058
Mouse
tumor necrosis factor mediated signaling pathwayGO:0033209130.058
protein localization to organelleGO:00333651850.058
negative regulation of defense responseGO:0031348770.056
Mouse
homeostasis of number of cellsGO:00488722100.056
regulation of cellular ketone metabolic processGO:0010565660.055
regulation of mapk cascadeGO:00434082480.054
regulation of transferase activityGO:00513382630.054
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.053
response to nitric oxideGO:007173140.053
wnt signaling pathwayGO:00160551880.051
regulation of cytokine productionGO:00018172660.051
Mouse
regulation of apoptotic signaling pathwayGO:20012331970.050
protein modification by small protein conjugation or removalGO:00706472070.048
lymphocyte differentiationGO:00300982420.048
toll like receptor signaling pathwayGO:0002224380.047
regulation of interleukin 6 productionGO:0032675550.046
Mouse
regulation of lymphocyte activationGO:00512492400.046
cytokine metabolic processGO:0042107710.045
positive regulation of lipopolysaccharide mediated signaling pathwayGO:003166650.045
stress activated protein kinase signaling cascadeGO:0031098810.045
negative regulation of growth of symbiont involved in interaction with hostGO:0044146190.042
negative regulation of apoptotic signaling pathwayGO:20012341040.042
response to organonitrogen compoundGO:00102432460.041
regulation of response to cytokine stimulusGO:0060759230.040
Human
defense response to other organismGO:00985421970.040
regulation of defense response to fungusGO:190015010.040
regulation of membrane potentialGO:00423911920.039
multicellular organismal homeostasisGO:00488711640.039
regulation of nucleotide binding oligomerization domain containing 2 signaling pathwayGO:007043230.039
interleukin 6 productionGO:0032635580.038
Mouse
cytokine biosynthetic processGO:0042089680.038
positive regulation of stress activated mapk cascadeGO:0032874480.037
positive regulation of kinase activityGO:00336741550.037
positive regulation of interleukin 6 biosynthetic processGO:004541060.037
interleukin 23 productionGO:003262720.036
innate immune responseGO:00450871570.036
positive regulation of cellular amine metabolic processGO:003324050.035
positive regulation of chemokine productionGO:0032722220.035
negative regulation of cellular amine metabolic processGO:003323910.034
epithelial cell developmentGO:00020641590.034
production of molecular mediator of immune responseGO:00024401030.034
Mouse
cytokine production involved in immune responseGO:0002367340.034
Mouse
positive regulation of nucleotide binding oligomerization domain containing signaling pathwayGO:007042620.034
positive regulation of jun kinase activityGO:0043507300.034
immune response activating cell surface receptor signaling pathwayGO:0002429720.033
purine ribonucleoside metabolic processGO:00461282410.033
regulation of leukocyte differentiationGO:19021051590.033
cellular response to lipidGO:00713961450.033
detection of molecule of bacterial originGO:003249020.033
regulation of stress activated mapk cascadeGO:0032872690.032
regulation of cellular amine metabolic processGO:0033238200.032
positive regulation of cellular amino acid metabolic processGO:004576430.032
amine metabolic processGO:0009308450.032
response to bacterial lipoproteinGO:003249340.032
negative regulation of phosphorus metabolic processGO:00105631840.032
Mouse
positive regulation of interferon alpha productionGO:003272740.032
response to peptidoglycanGO:003249490.032
immune effector processGO:00022523210.032
Mouse
cellular response to peptidoglycanGO:007122440.032
protein modification by small protein conjugationGO:00324461870.032
negative regulation of intracellular signal transductionGO:19025321670.032
Mouse
regulation of secretionGO:00510462740.032
positive regulation of interleukin 6 productionGO:0032755370.031
nucleotide binding oligomerization domain containing 1 signaling pathwayGO:007042750.031
translationGO:0006412930.031
regulation of wnt signaling pathwayGO:00301111230.031
nucleoside metabolic processGO:00091162460.030
immune response regulating cell surface receptor signaling pathwayGO:0002768800.030
chemokine metabolic processGO:0050755100.030
positive regulation of cytokine production involved in immune responseGO:0002720190.030
nucleotide metabolic processGO:00091173320.030
negative regulation of chemokine productionGO:003268240.030
adaptive immune responseGO:00022501550.029
regulation of interleukin 23 productionGO:003266720.029
positive regulation of jnk cascadeGO:0046330460.029
negative regulation of protein modification processGO:00314001630.029
Mouse
purine nucleoside metabolic processGO:00422782410.029
regulation of cytokine biosynthetic processGO:0042035590.028
posttranscriptional regulation of gene expressionGO:00106081550.028
neuron deathGO:00709971540.028
interferon beta productionGO:0032608160.028
negative regulation of molecular functionGO:00440922580.028
Human Mouse
positive regulation of cytokine productionGO:00018191740.028
response to molecule of bacterial originGO:00022371430.027
antimicrobial peptide productionGO:000277520.027
cellular response to interleukin 18GO:007135130.027
negative regulation of protein phosphorylationGO:00019331260.027
Mouse
anatomical structure homeostasisGO:00602491450.027
growth of symbiont in hostGO:0044117230.027
leukocyte differentiationGO:00025213420.027
leukocyte mediated immunityGO:00024431740.027
tissue homeostasisGO:00018941150.027
regulation of chemokine productionGO:0032642300.026
regulation of jun kinase activityGO:0043506400.026
positive regulation of interleukin 8 productionGO:003275720.026
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.026
lymphocyte mediated immunityGO:00024491390.026
purine nucleotide metabolic processGO:00061633020.025
positive regulation of cell activationGO:00508671580.025
regulation of reactive oxygen species metabolic processGO:2000377400.025
regulation of response to biotic stimulusGO:0002831380.025
reactive oxygen species metabolic processGO:0072593840.025
purine ribonucleoside triphosphate metabolic processGO:00092052200.025
response to oxidative stressGO:00069791230.024
interleukin 2 productionGO:0032623330.024
nitrogen compound transportGO:00717052710.024
regulation of antimicrobial humoral responseGO:000275930.024
cellular response to biotic stimulusGO:0071216920.024
regulation of map kinase activityGO:00434051200.024
positive regulation of antimicrobial humoral responseGO:000276020.024
regulation of protein ubiquitinationGO:0031396520.024
intrinsic apoptotic signaling pathwayGO:00971931320.024
regulation of production of molecular mediator of immune responseGO:0002700650.024
Mouse
heterocycle catabolic processGO:00467002800.024
regulation of multi organism processGO:00439001110.023
nucleobase containing small molecule metabolic processGO:00550863520.023
negative regulation of toll signaling pathwayGO:004575110.023
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.023
antibacterial peptide productionGO:000277820.023
regulation of chemokine secretionGO:009019640.022
regulation of interleukin 8 productionGO:003267730.022
regulation of chemokine biosynthetic processGO:004507380.022
humoral immune responseGO:0006959570.022
modulation of growth of symbiont involved in interaction with hostGO:0044144190.022
negative regulation of cellular amino acid metabolic processGO:004576300.022
positive regulation of antimicrobial peptide productionGO:000222510.022
endomembrane system organizationGO:00102561470.022
antigen receptor mediated signaling pathwayGO:0050851640.022
alpha beta t cell activationGO:0046631910.022
ion transmembrane transportGO:00342203610.022
positive regulation of nucleotide binding oligomerization domain containing 2 signaling pathwayGO:007043420.022
regulation of establishment of protein localizationGO:00702011810.022
aromatic compound catabolic processGO:00194392860.022
positive regulation of map kinase activityGO:0043406840.021
nucleotide binding oligomerization domain containing 2 signaling pathwayGO:007043160.021
negative regulation of protein metabolic processGO:00512482820.021
Mouse
regulation of cellular catabolic processGO:00313292420.021
t cell activationGO:00421102890.021
regulation of sequence specific dna binding transcription factor activityGO:00510901060.021
growth involved in symbiotic interactionGO:0044110230.021
compound eye developmentGO:004874910.021
protein k63 linked ubiquitinationGO:007053460.021
regulation of interferon beta biosynthetic processGO:004535740.021
extrinsic apoptotic signaling pathwayGO:00971911260.021
regulation of growth of symbiont in hostGO:0044126190.021
interleukin 10 secretionGO:007260840.021
positive regulation of cytokine biosynthetic processGO:0042108400.021
nucleoside phosphate catabolic processGO:19012922220.021
organonitrogen compound catabolic processGO:19015652640.020
purine nucleoside triphosphate metabolic processGO:00091442260.020
negative regulation of cell proliferationGO:00082852960.020
negative regulation of growth of symbiont in hostGO:0044130190.020
positive regulation of apoptotic processGO:00430652170.020
defense response to gram negative bacteriumGO:0050829280.020
action potentialGO:0001508780.020
regulation of symbiosis encompassing mutualism through parasitismGO:0043903520.020
nucleoside triphosphate metabolic processGO:00091412300.019
antibacterial peptide biosynthetic processGO:000278020.019
regulation of cytoplasmic transportGO:19036491120.019
negative regulation of response to cytokine stimulusGO:006076190.019
ribonucleoside triphosphate metabolic processGO:00091992200.019
myd88 independent toll like receptor signaling pathwayGO:000275630.019
ribonucleoside metabolic processGO:00091192450.019
3 utr mediated mrna stabilizationGO:007093520.019
growth of symbiont involved in interaction with hostGO:0044116230.019
negative regulation of interleukin 10 secretionGO:200118020.019
ripoptosome assembly involved in necroptotic processGO:190102660.019
proteolysis involved in cellular protein catabolic processGO:00516031470.019
protein catabolic processGO:00301632210.019
Mouse
regulation of cell cycleGO:00517262810.019
muscle cell proliferationGO:0033002520.018
macromolecule catabolic processGO:00090572810.018
Mouse
b cell activationGO:00421131610.018
purine ribonucleotide metabolic processGO:00091502900.018
b cell mediated immunityGO:0019724710.018
regulation of kinase activityGO:00435492490.018
response to organic cyclic compoundGO:00140701980.018
Mouse
defense response to virusGO:0051607680.018
transmission of nerve impulseGO:0019226760.018
cellular response to abiotic stimulusGO:0071214560.018
carbohydrate derivative biosynthetic processGO:19011371830.018
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.018
protein localization to endosomeGO:003601020.017
lymphocyte activation involved in immune responseGO:0002285930.017
regulation of t cell activationGO:00508631700.017
regulation of tumor necrosis factor superfamily cytokine productionGO:1903555500.017
Mouse
organelle localizationGO:00516401790.017
regulation of hormone levelsGO:00108172110.017
negative regulation of transferase activityGO:0051348850.017
Mouse
purine containing compound metabolic processGO:00725213110.017
cellular response to molecule of bacterial originGO:0071219830.017
tube closureGO:0060606910.017
interleukin 6 biosynthetic processGO:0042226120.017
neuronal action potentialGO:0019228540.017
regulation of protein complex assemblyGO:0043254830.017
regulation of leukocyte proliferationGO:00706631210.017
amide transportGO:00428861380.017
regulation of toll signaling pathwayGO:000859210.017
negative regulation of lymphocyte activationGO:0051250910.017
chemokine productionGO:0032602340.017
chemokine biosynthetic processGO:004203380.017
membrane organizationGO:00610242450.017
interleukin 33 mediated signaling pathwayGO:003817210.017
positive regulation of chemokine biosynthetic processGO:004508060.017
negative regulation of hormone metabolic processGO:003235140.017
canonical wnt signaling pathwayGO:00600701300.017
histone modificationGO:00165701590.017
ossificationGO:00015032160.016
positive regulation of nf kappab transcription factor activityGO:0051092300.016
negative regulation of cellular protein metabolic processGO:00322692470.016
Mouse
response to interleukin 1GO:0070555110.016
sterol transportGO:0015918380.016
tube formationGO:00351481400.016
regulation of interferon gamma productionGO:0032649570.016
cytoplasmic transportGO:00164822340.016
organophosphate catabolic processGO:00464342320.015
cellular response to oxidative stressGO:0034599760.015
nucleoside phosphate metabolic processGO:00067533380.015
skin developmentGO:00435882200.015
regulation of protein serine threonine kinase activityGO:00719001570.015
positive regulation of lymphocyte activationGO:00512511400.015
transmembrane transportGO:00550854120.015
nuclear transportGO:00511691390.015
mitotic cell cycle processGO:19030471590.015
positive regulation of transferase activityGO:00513471670.015
regulation of reactive oxygen species biosynthetic processGO:190342620.015
lipopolysaccharide mediated signaling pathwayGO:0031663250.015
nucleotide binding domain leucine rich repeat containing receptor signaling pathwayGO:003587260.015
ribose phosphate metabolic processGO:00196932910.015
regulation of protein modification by small protein conjugation or removalGO:1903320570.015
purine ribonucleoside triphosphate catabolic processGO:00092071990.014
inflammatory responseGO:00069542440.014
organic hydroxy compound metabolic processGO:19016152030.014
immunoglobulin mediated immune responseGO:0016064690.014
ribonucleotide metabolic processGO:00092592910.014
regulation of canonical wnt signaling pathwayGO:0060828820.014
regulation of lipopolysaccharide mediated signaling pathwayGO:003166490.014
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.014
protein secretionGO:00093061110.014
cellular nitrogen compound catabolic processGO:00442702800.014
multicellular organismal signalingGO:0035637910.014
purine nucleotide catabolic processGO:00061952110.014
nucleotide catabolic processGO:00091662170.014
positive regulation of leukocyte proliferationGO:0070665730.014
glycoprotein biosynthetic processGO:0009101890.014
negative regulation of interferon gamma productionGO:0032689180.014
negative regulation of sterol transportGO:003237240.014
regulation of t cell mediated immunityGO:0002709340.014
regulation of bindingGO:00510981110.014
mitochondrion organizationGO:00070051340.014
regulation of response to woundingGO:19030341890.014
negative regulation of cholesterol transportGO:003237540.013
morphogenesis of embryonic epitheliumGO:00163311590.013
protein glycosylationGO:0006486550.013
purine nucleoside triphosphate catabolic processGO:00091462030.013
regulation of secretion by cellGO:19035302490.013
glycosyl compound metabolic processGO:19016572460.013
cell type specific apoptotic processGO:00972852680.013
glycoprotein metabolic processGO:00091001160.013
jnk cascadeGO:0007254720.013
cellular response to lipopolysaccharideGO:0071222770.013
regulation of antimicrobial peptide productionGO:000278410.013
respiratory gaseous exchangeGO:0007585430.013
organophosphate biosynthetic processGO:00904071220.013
organonitrogen compound biosynthetic processGO:19015661920.013
positive regulation of immune effector processGO:00026991070.013
leukocyte apoptotic processGO:0071887710.013
peptidyl lysine modificationGO:0018205770.013
regionalizationGO:00030023370.013
reactive oxygen species biosynthetic processGO:190340980.013
glycosyl compound catabolic processGO:19016582060.012
regulation of protein localization to nucleusGO:1900180600.012
respiratory tube developmentGO:00303231670.012
skeletal system developmentGO:00015013560.012
protein acylationGO:0043543640.012
peptidyl tyrosine phosphorylationGO:00181081430.012
cation transportGO:00068123990.012
dna repairGO:00062811070.012
macromolecule glycosylationGO:0043413550.012
lung developmentGO:00303241640.012
cellular response to cytokine stimulusGO:00713451890.012
glycosylationGO:0070085620.012
purine containing compound catabolic processGO:00725232130.012
negative regulation of chemokine biosynthetic processGO:004507920.012
response to inorganic substanceGO:0010035960.012
cellular response to growth factor stimulusGO:00713631970.012
g protein coupled receptor signaling pathwayGO:00071862430.012
positive regulation of secretionGO:00510471300.012
regulation of interleukin 12 productionGO:0032655300.012
Mouse
organic hydroxy compound transportGO:0015850930.012
carbohydrate homeostasisGO:00335001280.012
positive regulation of production of molecular mediator of immune responseGO:0002702450.012
rho protein signal transductionGO:0007266320.012
negative regulation of cell activationGO:00508661110.012
response to interleukin 18GO:007067340.012
positive regulation of lymphocyte proliferationGO:0050671700.012
microtubule based processGO:00070172360.012
muscle cell differentiationGO:00426922610.012
cellular response to acid chemicalGO:0071229680.012
interleukin 8 productionGO:003263740.012
regulation of adaptive immune responseGO:0002819900.011
chromatin organizationGO:00063252060.011
regulation of translationGO:0006417710.011
nik nf kappab signalingGO:0038061140.011
Human
negative regulation of lymphocyte proliferationGO:0050672450.011
carbohydrate derivative catabolic processGO:19011362310.011
regulation of protein transportGO:00512231630.011
regulation of interleukin 2 productionGO:0032663280.011
negative regulation of multi organism processGO:0043901680.011
epithelial cell proliferationGO:00506731740.011
symbiosis encompassing mutualism through parasitismGO:0044403830.011
t cell receptor signaling pathwayGO:0050852460.011
response to reactive oxygen speciesGO:0000302560.011
epidermis developmentGO:00085441870.011
negative regulation of protein modification by small protein conjugation or removalGO:1903321200.011
negative regulation of protein ubiquitinationGO:0031397190.011
regulation of alpha beta t cell activationGO:0046634530.011
steroid metabolic processGO:00082021190.011
lymphocyte apoptotic processGO:0070227540.011
adult locomotory behaviorGO:0008344910.011
cellular response to organonitrogen compoundGO:00714171450.011
exocytosisGO:00068871210.011
peptide transportGO:00158331330.011
detection of stimulusGO:0051606840.011
regulation of toll like receptor signaling pathwayGO:0034121200.011
Mouse
guanosine containing compound catabolic processGO:19010691440.011
atp metabolic processGO:0046034750.011
jak stat cascadeGO:0007259420.011
primary neural tube formationGO:0014020950.011
lipid localizationGO:00108761260.010
synaptic transmissionGO:00072683290.010
lateral inhibitionGO:004633110.010
tumor necrosis factor superfamily cytokine productionGO:0071706510.010
Mouse
cellular homeostasisGO:00197252400.010
endothelium developmentGO:0003158450.010
midgut developmentGO:000749440.010
regulation of rna stabilityGO:0043487260.010
cation transmembrane transportGO:00986552660.010
negative regulation of leukocyte proliferationGO:0070664460.010
regulation of lymphocyte mediated immunityGO:0002706840.010
interleukin 12 biosynthetic processGO:004209080.010
carbohydrate metabolic processGO:00059752300.010
interspecies interaction between organismsGO:0044419830.010
myd88 dependent toll like receptor signaling pathwayGO:000275570.010
protein localization to plasma membraneGO:0072659570.010
chromatin modificationGO:00165681870.010
glucose homeostasisGO:00425931280.010
neural tube closureGO:0001843900.010
alpha beta t cell proliferationGO:0046633210.010
regulation of myeloid cell differentiationGO:0045637960.010
myosin filament assemblyGO:003103420.010
positive regulation of multi organism processGO:0043902260.010
plasma membrane organizationGO:0007009900.010
rhythmic processGO:00485111740.010
type i interferon biosynthetic processGO:004535190.010
positive regulation of protein import into nucleusGO:0042307260.010
regulation of protein localizationGO:00328802310.010
hormone secretionGO:00468791280.010

Irak1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.025
organ system cancerDOID:005068600.024
cancerDOID:16200.024
disease of cellular proliferationDOID:1456600.024
nervous system diseaseDOID:86300.019
disease of anatomical entityDOID:700.019
musculoskeletal system diseaseDOID:1700.017
hematologic cancerDOID:253100.017
immune system cancerDOID:006008300.017
eye and adnexa diseaseDOID:149200.015
retinal diseaseDOID:567900.015
eye diseaseDOID:561400.015
sensory system diseaseDOID:005015500.015
bone diseaseDOID:008000100.014
connective tissue diseaseDOID:6500.014
inherited metabolic disorderDOID:65500.011