Mus musculus

37 known processes

Map3k12

mitogen-activated protein kinase kinase kinase 12

(Aliases: DLK,Zpk,MUK)

Map3k12 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of membrane potentialGO:00423911920.122
transmembrane transportGO:00550854120.099
ion transmembrane transportGO:00342203610.097
apoptotic signaling pathwayGO:00971903060.080
regulation of kinase activityGO:00435492490.080
Worm
regulation of postsynaptic membrane potentialGO:0060078480.065
membrane depolarizationGO:0051899640.063
intrinsic apoptotic signaling pathwayGO:00971931320.057
cellular ketone metabolic processGO:0042180840.056
regulation of cellular catabolic processGO:00313292420.056
negative regulation of molecular functionGO:00440922580.054
anion transportGO:00068201770.054
cytoplasmic transportGO:00164822340.053
synaptic transmissionGO:00072683290.045
Worm Fly
regulation of actin filament based processGO:0032970990.043
nitrogen compound transportGO:00717052710.043
regulation of protein serine threonine kinase activityGO:00719001570.042
Worm
muscle tissue developmentGO:00605373080.042
negative regulation of phosphate metabolic processGO:00459361840.041
positive regulation of kinase activityGO:00336741550.041
Worm
dna repairGO:00062811070.039
nucleotide metabolic processGO:00091173320.039
regulation of protein kinase activityGO:00458592320.039
Worm
regulation of cellular amino acid metabolic processGO:000652150.038
positive regulation of protein phosphorylationGO:00019342420.037
Worm
male gamete generationGO:00482322850.035
Fly
neuron neuron synaptic transmissionGO:0007270690.035
macromolecule catabolic processGO:00090572810.034
regulation of apoptotic signaling pathwayGO:20012331970.034
multicellular organismal response to stressGO:0033555620.034
negative regulation of protein metabolic processGO:00512482820.034
lipid transportGO:0006869980.033
regulation of cellular amine metabolic processGO:0033238200.033
regulation of secretionGO:00510462740.032
respiratory system developmentGO:00605411900.032
regulation of excitatory postsynaptic membrane potentialGO:0060079410.032
regulation of transmembrane transportGO:00347621280.032
organic anion transportGO:00157111370.032
regulation of stress activated mapk cascadeGO:0032872690.032
lung developmentGO:00303241640.032
negative regulation of phosphorylationGO:00423261660.032
organelle localizationGO:00516401790.031
dna metabolic processGO:00062593030.031
protein modification by small protein conjugationGO:00324461870.031
regulation of jnk cascadeGO:0046328620.031
endomembrane system organizationGO:00102561470.031
Fly
cellular nitrogen compound catabolic processGO:00442702800.031
protein localization to organelleGO:00333651850.031
learning or memoryGO:00076111480.031
regulation of intrinsic apoptotic signaling pathwayGO:2001242610.031
exocytosisGO:00068871210.031
nucleoside metabolic processGO:00091162460.031
actin cytoskeleton organizationGO:00300362200.030
vesicle localizationGO:0051648860.030
cytoskeleton dependent intracellular transportGO:0030705500.030
regulation of cellular response to stressGO:00801351590.030
cell adhesionGO:00071553290.029
leukocyte differentiationGO:00025213420.029
multicellular organismal signalingGO:0035637910.029
regulation of ion transportGO:00432692150.029
intracellular protein transportGO:00068862040.029
jnk cascadeGO:0007254720.029
regulation of organelle organizationGO:00330432890.029
homeostasis of number of cellsGO:00488722100.028
regulation of cytoskeleton organizationGO:00514931220.028
stem cell proliferationGO:00720891170.028
microtubule based transportGO:0010970500.028
regulation of hydrolase activityGO:00513362460.027
aromatic compound catabolic processGO:00194392860.027
establishment of organelle localizationGO:00516561220.027
axon cargo transportGO:0008088330.027
regulation of transferase activityGO:00513382630.027
Worm
amine metabolic processGO:0009308450.027
fat cell differentiationGO:00454441600.027
protein targetingGO:00066051430.027
mitotic cell cycleGO:00002781950.027
protein importGO:00170381010.026
negative regulation of transferase activityGO:0051348850.026
protein polymerizationGO:0051258570.026
nuclear divisionGO:00002801580.026
stress activated mapk cascadeGO:0051403800.026
heterocycle catabolic processGO:00467002800.026
negative regulation of protein modification processGO:00314001630.026
posttranscriptional regulation of gene expressionGO:00106081550.025
nucleocytoplasmic transportGO:00069131390.025
meiotic cell cycleGO:00513211220.025
positive regulation of nervous system developmentGO:00519622210.025
blood circulationGO:00080151950.025
negative regulation of jun kinase activityGO:004350890.025
cellular response to dna damage stimulusGO:00069742070.024
hormone secretionGO:00468791280.024
regulation of hormone levelsGO:00108172110.024
ossificationGO:00015032160.024
protein import into nucleusGO:0006606950.024
fear responseGO:0042596330.024
peptide transportGO:00158331330.024
response to amino acidGO:0043200370.024
carbohydrate derivative biosynthetic processGO:19011371830.024
myeloid cell differentiationGO:00300992330.024
gland developmentGO:00487323300.023
stem cell maintenanceGO:00198271300.023
response to organonitrogen compoundGO:00102432460.023
g protein coupled receptor signaling pathwayGO:00071862430.023
neuronal action potentialGO:0019228540.023
peptide hormone secretionGO:00300721090.023
purine nucleotide catabolic processGO:00061952110.023
skeletal system developmentGO:00015013560.022
positive regulation of apoptotic processGO:00430652170.022
spermatogenesisGO:00072832840.022
Fly
negative regulation of cellular protein metabolic processGO:00322692470.022
steroid metabolic processGO:00082021190.022
divalent inorganic cation transportGO:00725111780.022
wnt signaling pathwayGO:00160551880.022
stress activated protein kinase signaling cascadeGO:0031098810.022
negative regulation of protein phosphorylationGO:00019331260.022
synaptic vesicle transportGO:0048489570.022
regulation of receptor activityGO:0010469410.022
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.022
organic cyclic compound catabolic processGO:19013612950.021
multicellular organism growthGO:00352641610.021
digestive system developmentGO:00551232000.021
negative regulation of phosphorus metabolic processGO:00105631840.021
microtubule based processGO:00070172360.021
positive regulation of homeostatic processGO:0032846640.021
glycoprotein metabolic processGO:00091001160.021
ribonucleoside metabolic processGO:00091192450.021
defecationGO:003042110.021
purine ribonucleoside metabolic processGO:00461282410.021
behavioral fear responseGO:0001662280.021
connective tissue developmentGO:00614481790.021
cellular lipid metabolic processGO:00442553230.021
regulation of map kinase activityGO:00434051200.021
Worm
translationGO:0006412930.021
regulation of cell cycleGO:00517262810.020
purine containing compound metabolic processGO:00725213110.020
ribonucleotide metabolic processGO:00092592910.020
regulation of actin cytoskeleton organizationGO:0032956840.020
nucleoside catabolic processGO:00091642060.020
regulation of homeostatic processGO:00328441820.020
organic hydroxy compound metabolic processGO:19016152030.020
protein modification by small protein conjugation or removalGO:00706472070.020
axonogenesisGO:00074092740.020
Fly
embryonic placenta developmentGO:0001892980.020
organonitrogen compound biosynthetic processGO:19015661920.020
leukocyte migrationGO:00509001240.020
regulation of establishment of protein localizationGO:00702011810.019
learningGO:0007612980.019
placenta developmentGO:00018901400.019
digestive tract morphogenesisGO:00485461470.019
response to molecule of bacterial originGO:00022371430.019
axon transport of mitochondrionGO:001989620.019
muscle contractionGO:00069361010.019
negative regulation of intrinsic apoptotic signaling pathwayGO:2001243340.019
regulation of protein catabolic processGO:00421761080.019
membrane organizationGO:00610242450.019
forebrain developmentGO:00309003020.019
purine ribonucleotide metabolic processGO:00091502900.019
ribose phosphate metabolic processGO:00196932910.019
positive regulation of cellular amino acid metabolic processGO:004576430.019
striated muscle tissue developmentGO:00147062930.019
appendage developmentGO:00487361660.019
cytokine productionGO:00018163190.019
cellular amine metabolic processGO:0044106440.019
actin polymerization or depolymerizationGO:0008154540.019
negative regulation of intracellular signal transductionGO:19025321670.018
negative regulation of protein serine threonine kinase activityGO:0071901490.018
camera type eye developmentGO:00430102660.018
regulation of mapk cascadeGO:00434082480.018
Worm
multi multicellular organism processGO:00447061090.018
negative regulation of kinase activityGO:0033673810.018
cerebellum morphogenesisGO:0021587420.018
microtubule based movementGO:0007018840.018
purine nucleoside triphosphate metabolic processGO:00091442260.018
purine nucleotide metabolic processGO:00061633020.018
regulation of system processGO:00440572000.018
positive regulation of protein kinase activityGO:00458601440.018
Worm
cognitionGO:00508901490.018
cellular amino acid metabolic processGO:00065201030.018
oxidation reduction processGO:00551143420.018
cardiac muscle tissue developmentGO:00487381300.018
establishment of vesicle localizationGO:0051650810.018
nucleoside phosphate metabolic processGO:00067533380.018
sequestering of calcium ionGO:0051208180.018
regulation of secretion by cellGO:19035302490.018
sequestering of metal ionGO:0051238190.018
meiotic nuclear divisionGO:00071261150.017
regulation of stem cell proliferationGO:0072091780.017
canonical wnt signaling pathwayGO:00600701300.017
transmission of nerve impulseGO:0019226760.017
t cell activationGO:00421102890.017
alcohol metabolic processGO:00060661160.017
response to lipopolysaccharideGO:00324961280.017
embryonic limb morphogenesisGO:00303261260.017
positive regulation of cellular catabolic processGO:00313311480.017
reactive oxygen species metabolic processGO:0072593840.017
carboxylic acid transportGO:00469421000.017
regulation of cellular ketone metabolic processGO:0010565660.017
glycoprotein biosynthetic processGO:0009101890.017
actin filament based movementGO:0030048230.017
mapk cascadeGO:00001652810.017
Worm
gastrulationGO:00073691160.017
reactive nitrogen species metabolic processGO:200105700.017
neurotransmitter secretionGO:0007269620.017
respiratory tube developmentGO:00303231670.017
purine nucleoside metabolic processGO:00422782410.017
behavioral defense responseGO:0002209280.017
nucleobase containing small molecule metabolic processGO:00550863520.017
skeletal muscle organ developmentGO:00605381630.017
regulation of transporter activityGO:0032409570.016
regulation of protein localizationGO:00328802310.016
adult locomotory behaviorGO:0008344910.016
rna processingGO:00063961050.016
action potentialGO:0001508780.016
cellular response to biotic stimulusGO:0071216920.016
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.016
cell type specific apoptotic processGO:00972852680.016
endocytosisGO:00068971680.016
ribonucleotide catabolic processGO:00092612080.016
epidermis developmentGO:00085441870.016
proteolysis involved in cellular protein catabolic processGO:00516031470.016
nucleoside phosphate catabolic processGO:19012922220.016
cellular response to lipidGO:00713961450.016
determination of left right symmetryGO:0007368800.016
cartilage developmentGO:00512161400.016
regulation of cell migrationGO:00303342190.016
negative regulation of apoptotic signaling pathwayGO:20012341040.016
dna recombinationGO:0006310920.016
carbohydrate derivative catabolic processGO:19011362310.016
nuclear transportGO:00511691390.016
regulation of jun kinase activityGO:0043506400.016
purine containing compound catabolic processGO:00725232130.016
leukocyte proliferationGO:00706611720.015
tissue remodelingGO:00487711020.015
peptide secretionGO:00027901140.015
fertilizationGO:00095661270.015
neuron projection guidanceGO:00974851410.015
lipid localizationGO:00108761260.015
response to radiationGO:00093141650.015
leukocyte mediated immunityGO:00024431740.015
retina development in camera type eyeGO:00600411190.015
modification dependent protein catabolic processGO:00199411330.015
carbohydrate homeostasisGO:00335001280.015
protein processingGO:00164851630.015
positive regulation of mapk cascadeGO:00434101700.015
Worm
regulation of reactive oxygen species metabolic processGO:2000377400.015
anion transmembrane transportGO:0098656710.015
t cell differentiationGO:00302171740.014
regulation of lymphocyte activationGO:00512492400.014
glial cell differentiationGO:00100011310.014
regulation of phospholipase a2 activityGO:003242930.014
organelle fissionGO:00482851700.014
synaptic vesicle localizationGO:0097479590.014
positive regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:200006080.014
sensory perceptionGO:00076002450.014
dendrite developmentGO:00163581150.014
purine ribonucleoside catabolic processGO:00461302050.014
protein maturationGO:00516041760.014
regulation of cell morphogenesis involved in differentiationGO:00107691510.014
protein ubiquitinationGO:00165671710.014
positive regulation of nucleotide metabolic processGO:00459811140.014
neuromuscular processGO:0050905990.014
glycosyl compound metabolic processGO:19016572460.014
tissue homeostasisGO:00018941150.014
angiogenesisGO:00015252010.014
glycosyl compound catabolic processGO:19016582060.014
rna interferenceGO:001624620.014
cell divisionGO:00513011200.014
ribonucleoside triphosphate metabolic processGO:00091992200.014
gene silencingGO:0016458380.014
rho protein signal transductionGO:0007266320.014
regulation of wnt signaling pathwayGO:00301111230.014
macromolecular complex disassemblyGO:0032984430.014
negative regulation of cell cycleGO:00457861230.014
mitotic cell cycle processGO:19030471590.014
regulation of leukocyte mediated immunityGO:00027031040.014
purine ribonucleotide catabolic processGO:00091542080.013
regulation of sequence specific dna binding transcription factor activityGO:00510901060.013
formation of radial glial scaffoldsGO:002194340.013
negative regulation of wnt signaling pathwayGO:0030178730.013
positive regulation of programmed cell deathGO:00430682180.013
regulation of muscle tissue developmentGO:1901861970.013
amide transportGO:00428861380.013
nuclear importGO:0051170950.013
adult behaviorGO:00305341350.013
gonad developmentGO:00084061410.013
leukocyte activation involved in immune responseGO:00023661260.013
regulation of intracellular transportGO:00323861590.013
cellular response to molecule of bacterial originGO:0071219830.013
cellular response to organonitrogen compoundGO:00714171450.013
genitalia developmentGO:0048806370.013
reactive oxygen species biosynthetic processGO:190340980.013
insulin secretionGO:0030073890.013
regulation of striated muscle cell differentiationGO:0051153810.013
embryonic organ morphogenesisGO:00485622760.013
purine nucleoside triphosphate catabolic processGO:00091462030.013
intestinal epithelial structure maintenanceGO:006072940.013
myeloid cell homeostasisGO:00022621140.013
regulation of epithelial cell proliferationGO:00506781410.013
modification dependent macromolecule catabolic processGO:00436321330.013
regulation of nucleotide metabolic processGO:00061401690.013
oligodendrocyte differentiationGO:0048709530.013
kidney developmentGO:00018222130.013
axon guidanceGO:00074111410.013
protein localization to nucleusGO:00345041210.013
cell activation involved in immune responseGO:00022631260.013
positive regulation of stem cell proliferationGO:2000648590.013
positive regulation of lipid transportGO:0032370220.013
cellular response to acid chemicalGO:0071229680.013
regulation of protein transportGO:00512231630.013
b cell activationGO:00421131610.012
actin mediated cell contractionGO:0070252150.012
maintenance of locationGO:0051235890.012
nucleoside triphosphate catabolic processGO:00091432050.012
establishment of synaptic vesicle localizationGO:0097480570.012
neural precursor cell proliferationGO:00613511210.012
muscle system processGO:00030121410.012
cardiac cell fate specificationGO:006091220.012
negative regulation of mapk cascadeGO:0043409650.012
artery developmentGO:0060840530.012
chemotaxisGO:00069352470.012
branching morphogenesis of an epithelial tubeGO:00487541590.012
regulation of cell cycle processGO:00105641600.012
mechanoreceptor differentiationGO:0042490670.012
regulation of cellular component sizeGO:00325351210.012
regulation of peptide transportGO:0090087910.012
regulation of vesicle mediated transportGO:00606271390.012
morphogenesis of a branching epitheliumGO:00611381930.012
positive regulation of cytokine productionGO:00018191740.012
nucleoside triphosphate metabolic processGO:00091412300.012
regulation of synaptic transmission glutamatergicGO:0051966190.012
regulation of cell activationGO:00508652890.012
limb morphogenesisGO:00351081490.012
purine ribonucleoside triphosphate metabolic processGO:00092052200.012
regulation of bindingGO:00510981110.012
negative regulation of cell proliferationGO:00082852960.012
skin developmentGO:00435882200.012
mrna metabolic processGO:0016071840.012
skeletal system morphogenesisGO:00487052030.012
bone mineralizationGO:0030282540.012
regulation of ion transmembrane transporter activityGO:0032412540.012
sensory perception of soundGO:0007605970.012
peptidyl amino acid modificationGO:00181933360.012
single organism nuclear importGO:1902593950.012
cardiac chamber morphogenesisGO:0003206930.012
positive regulation of stress activated mapk cascadeGO:0032874480.012
response to acid chemicalGO:00011011110.012
glutamate receptor signaling pathwayGO:0007215350.012
wound healingGO:00420601570.012
hindbrain morphogenesisGO:0021575460.012
positive regulation of proteolysisGO:0045862850.012
regulation of n methyl d aspartate selective glutamate receptor activityGO:2000310100.012
regulation of cellular component biogenesisGO:00440871810.012
rhythmic processGO:00485111740.012
protein oligomerizationGO:0051259670.012
cardiac muscle contractionGO:0060048320.012
purine nucleoside catabolic processGO:00061522050.012
response to organic cyclic compoundGO:00140701980.012
positive regulation of protein transportGO:0051222930.012
plasma membrane organizationGO:0007009900.012
telencephalon developmentGO:00215371860.011
lymphocyte proliferationGO:00466511640.011
spermatid differentiationGO:00485151150.011
organonitrogen compound catabolic processGO:19015652640.011
palate developmentGO:0060021760.011
purine ribonucleoside triphosphate catabolic processGO:00092071990.011
actin filament polymerizationGO:0030041440.011
reproductive behaviorGO:0019098320.011
regulation of leukocyte differentiationGO:19021051590.011
regulation of protein ubiquitinationGO:0031396520.011
cardiac muscle cell contractionGO:008600370.011
ear developmentGO:00435832000.011
protein catabolic processGO:00301632210.011
positive regulation of reactive oxygen species biosynthetic processGO:190342820.011
lipid biosynthetic processGO:00086101790.011
inflammatory responseGO:00069542440.011
cardiac chamber developmentGO:00032051080.011
hematopoietic progenitor cell differentiationGO:00022441430.011
regulation of peptide secretionGO:0002791770.011
microtubule cytoskeleton organizationGO:00002261570.011
regulation of lipid metabolic processGO:00192161180.011
monocarboxylic acid metabolic processGO:00327871910.011
regulation of cytoplasmic transportGO:19036491120.011
muscle cell differentiationGO:00426922610.011
cellular ion homeostasisGO:00068731650.011
compound eye developmentGO:004874910.011
small gtpase mediated signal transductionGO:0007264970.011
ras protein signal transductionGO:0007265770.011
regulation of dna bindingGO:0051101390.011
carbohydrate metabolic processGO:00059752300.011
regulation of actin polymerization or depolymerizationGO:0008064450.011
spermatid developmentGO:00072861080.011
regulation of anatomical structure sizeGO:00900661780.011
regulation of fat cell differentiationGO:0045598810.011
germ cell developmentGO:00072811850.011
positive regulation of cellular protein catabolic processGO:1903364340.011
regulation of ion homeostasisGO:2000021640.011
positive regulation of protein catabolic processGO:0045732600.011
protein autophosphorylationGO:0046777610.011
cellular protein complex assemblyGO:00436231160.011
positive regulation of transferase activityGO:00513471670.011
Worm
cellular response to ammonium ionGO:007124220.011
regulation of cellular protein catabolic processGO:1903362610.011
regulation of purine nucleotide metabolic processGO:19005421690.011
regulation of protein complex assemblyGO:0043254830.010
appendage morphogenesisGO:00351071490.010
negative regulation of cellular amino acid metabolic processGO:004576300.010
response to monosaccharideGO:0034284670.010
negative regulation of immune system processGO:00026832090.010
positive regulation of protein modification processGO:00314012990.010
Worm
regulation of neuron deathGO:19012141340.010
glucose homeostasisGO:00425931280.010
t cell proliferationGO:00420981200.010
cation transmembrane transportGO:00986552660.010
organic acid transportGO:00158491010.010
meiotic cell cycle processGO:1903046770.010
cell maturationGO:00484691270.010
positive regulation of leukocyte mediated immunityGO:0002705700.010
cellular macromolecule catabolic processGO:00442652060.010
negative regulation of fat cell differentiationGO:0045599360.010
multi organism behaviorGO:0051705620.010
cellular homeostasisGO:00197252400.010
positive regulation of secretionGO:00510471300.010
positive regulation of cell developmentGO:00107202370.010
blastocyst developmentGO:0001824800.010
immune effector processGO:00022523210.010

Map3k12 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.072
acquired metabolic diseaseDOID:006015800.030
carbohydrate metabolism diseaseDOID:005001300.030
glucose metabolism diseaseDOID:419400.026
diabetes mellitusDOID:935100.024
nervous system diseaseDOID:86300.024
disease of anatomical entityDOID:700.024
type 2 diabetes mellitusDOID:935200.020
central nervous system diseaseDOID:33100.012
neurodegenerative diseaseDOID:128900.012
sensory system diseaseDOID:005015500.011
disease of cellular proliferationDOID:1456600.011
cancerDOID:16200.011
eye and adnexa diseaseDOID:149200.010