IMP: Integrative Multi-species Prediction

Mus musculus

68 known processes

Spib

Spi-B transcription factor (Spi-1/PU.1 related)

(Aliases: Spi-B)

Ensembl: ENSMUSG00000008193
Entrez: 272382
UniProtKB: O35906

Process Predictions
Disease Predictions

Spib biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
immune response activating signal transduction	GO:0002757	116	0.784
lymphocyte differentiation	GO:0030098	242	0.779	Mouse
t cell activation	GO:0042110	289	0.762
regulation of lymphocyte activation	GO:0051249	240	0.727
regulation of cell activation	GO:0050865	289	0.688
cytokine production	GO:0001816	319	0.678
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.661
inflammatory response	GO:0006954	244	0.635
leukocyte proliferation	GO:0070661	172	0.624
defense response to other organism	GO:0098542	197	0.623
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.598
cellular ion homeostasis	GO:0006873	165	0.579
regulation of b cell proliferation	GO:0030888	39	0.570
activation of immune response	GO:0002253	138	0.554
negative regulation of cell activation	GO:0050866	111	0.546
positive regulation of cell activation	GO:0050867	158	0.541
response to molecule of bacterial origin	GO:0002237	143	0.535
innate immune response	GO:0045087	157	0.535
cation homeostasis	GO:0055080	212	0.529
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.527
b cell proliferation	GO:0042100	53	0.524
myeloid leukocyte activation	GO:0002274	83	0.502	Mouse
positive regulation of t cell activation	GO:0050870	101	0.470
cytokine secretion	GO:0050663	72	0.456
forebrain development	GO:0030900	302	0.445
cellular calcium ion homeostasis	GO:0006874	119	0.440
negative regulation of synapse assembly	GO:0051964	3	0.439
cellular chemical homeostasis	GO:0055082	215	0.438
leukocyte differentiation	GO:0002521	342	0.436
regulation of homeostatic process	GO:0032844	182	0.418
fatty acid biosynthetic process	GO:0006633	41	0.410
leukocyte migration	GO:0050900	124	0.399
regulation of cell motility	GO:2000145	236	0.386
negative regulation of defense response	GO:0031348	77	0.385
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.383
t cell differentiation	GO:0030217	174	0.383
g protein coupled receptor signaling pathway	GO:0007186	243	0.374
regulation of leukocyte proliferation	GO:0070663	121	0.373
cell adhesion	GO:0007155	329	0.372
positive regulation of cytokine production	GO:0001819	174	0.367
dendritic cell differentiation	GO:0097028	26	0.362	Mouse
adaptive immune response	GO:0002250	155	0.358
positive regulation of cell development	GO:0010720	237	0.355
microglial cell activation involved in immune response	GO:0002282	1	0.352
negative regulation of cell proliferation	GO:0008285	296	0.350
myeloid cell differentiation	GO:0030099	233	0.349
cellular homeostasis	GO:0019725	240	0.340
axonogenesis	GO:0007409	274	0.337
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.332
regulation of map kinase activity	GO:0043405	120	0.329
neuron projection guidance	GO:0097485	141	0.329
regulation of organelle organization	GO:0033043	289	0.319
divalent inorganic cation homeostasis	GO:0072507	138	0.316
positive regulation of nervous system development	GO:0051962	221	0.308
t cell proliferation	GO:0042098	120	0.302
regulation of cytokine production	GO:0001817	266	0.297
positive regulation of t cell receptor signaling pathway	GO:0050862	4	0.296
mast cell degranulation	GO:0043303	19	0.295
regulation of t cell activation	GO:0050863	170	0.293
regulation of ion homeostasis	GO:2000021	64	0.291
ras protein signal transduction	GO:0007265	77	0.288
negative regulation of immune system process	GO:0002683	209	0.286
regulation of mast cell activation	GO:0033003	21	0.281
cerebral cortex development	GO:0021987	86	0.281
immune effector process	GO:0002252	321	0.280
negative regulation of lymphocyte activation	GO:0051250	91	0.277
immune response regulating signaling pathway	GO:0002764	125	0.273
maintenance of location	GO:0051235	89	0.271
positive regulation of cytokine biosynthetic process	GO:0042108	40	0.270
lymphocyte proliferation	GO:0046651	164	0.269
regulation of protein serine threonine kinase activity	GO:0071900	157	0.269
positive regulation of homeostatic process	GO:0032846	64	0.266
regulation of anatomical structure size	GO:0090066	178	0.266
positive regulation of secretion	GO:0051047	130	0.261
regulation of secretion	GO:0051046	274	0.261
chemotaxis	GO:0006935	247	0.260
activation of innate immune response	GO:0002218	56	0.259
regulation of membrane potential	GO:0042391	192	0.253
regulation of toll like receptor 4 signaling pathway	GO:0034143	4	0.252
multicellular organismal homeostasis	GO:0048871	164	0.248
sequestering of calcium ion	GO:0051208	18	0.248
cytosolic calcium ion homeostasis	GO:0051480	70	0.247
lymphocyte apoptotic process	GO:0070227	54	0.237
olfactory learning	GO:0008355	2	0.235
activation of mapk activity	GO:0000187	59	0.233
regulation of response to wounding	GO:1903034	189	0.230
single organismal cell cell adhesion	GO:0016337	131	0.229
regulation of neuron projection development	GO:0010975	169	0.228
actin filament organization	GO:0007015	113	0.225
cellular metal ion homeostasis	GO:0006875	151	0.225
regulation of mapk cascade	GO:0043408	248	0.224
regulation of secretion by cell	GO:1903530	249	0.224
antigen receptor mediated signaling pathway	GO:0050851	64	0.224
regulation of lymphocyte proliferation	GO:0050670	117	0.223
positive regulation of t cell differentiation	GO:0045582	52	0.223
helper t cell chemotaxis	GO:0035704	1	0.220
regulation of cellular component size	GO:0032535	121	0.220
heart morphogenesis	GO:0003007	178	0.219
regulation of eosinophil degranulation	GO:0043309	1	0.217
regulation of defense response	GO:0031347	233	0.214
b cell homeostasis	GO:0001782	34	0.212
alpha beta t cell activation	GO:0046631	91	0.211
chemokine mediated signaling pathway	GO:0070098	17	0.211
metal ion homeostasis	GO:0055065	189	0.210
exocytosis	GO:0006887	121	0.209
actin polymerization or depolymerization	GO:0008154	54	0.207
positive regulation of cd8 positive alpha beta t cell extravasation	GO:2000451	2	0.205
bone resorption	GO:0045453	38	0.205
regulation of innate immune response	GO:0045088	91	0.203
positive regulation of innate immune response	GO:0045089	80	0.203
regulation of cell adhesion	GO:0030155	154	0.203
glial cell differentiation	GO:0010001	131	0.202
regulation of cellular component biogenesis	GO:0044087	181	0.202
leukocyte chemotaxis	GO:0030595	69	0.196
granulocyte migration	GO:0097530	43	0.195
negative regulation of lymphocyte proliferation	GO:0050672	45	0.192
cd8 positive alpha beta t cell extravasation	GO:0035697	3	0.191
eosinophil activation	GO:0043307	1	0.191
axon guidance	GO:0007411	141	0.188
regulation of blood coagulation	GO:0030193	28	0.187
regulation of leukocyte differentiation	GO:1902105	159	0.187	Zebrafish
platelet activation	GO:0030168	40	0.185
negative regulation of eosinophil degranulation	GO:0043310	1	0.184
cation transport	GO:0006812	399	0.183
positive regulation of protein secretion	GO:0050714	52	0.183
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.183
tissue remodeling	GO:0048771	102	0.182
nephric duct formation	GO:0072179	4	0.178
positive regulation of cell migration	GO:0030335	109	0.177
calcium ion transport into cytosol	GO:0060402	48	0.176
action potential	GO:0001508	78	0.176
positive regulation of secretion by cell	GO:1903532	114	0.175
interferon gamma production	GO:0032609	67	0.174
membrane organization	GO:0061024	245	0.171
positive regulation of lymphocyte activation	GO:0051251	140	0.170
tolerance induction to self antigen	GO:0002513	4	0.170
t cell differentiation in thymus	GO:0033077	77	0.169
calcium ion homeostasis	GO:0055074	127	0.167
mast cell activation	GO:0045576	27	0.167
positive regulation of cellular component biogenesis	GO:0044089	94	0.165
i kappab kinase nf kappab signaling	GO:0007249	85	0.164
lipoxin a4 biosynthetic process	GO:2001303	1	0.163
optic nerve structural organization	GO:0021633	2	0.162
positive regulation of podosome assembly	GO:0071803	3	0.159
regulation of protein complex assembly	GO:0043254	83	0.156
actin filament bundle assembly	GO:0051017	40	0.155
positive regulation of leukocyte degranulation	GO:0043302	10	0.155
regulation of kinase activity	GO:0043549	249	0.154
associative learning	GO:0008306	61	0.154
negative regulation of homeostatic process	GO:0032845	71	0.152
mapk cascade	GO:0000165	281	0.152
monocyte extravasation	GO:0035696	2	0.152
negative regulation of protein serine threonine kinase activity	GO:0071901	49	0.152
regulation of vesicle mediated transport	GO:0060627	139	0.150
positive regulation of cell motility	GO:2000147	116	0.150
b cell activation	GO:0042113	161	0.150
cognition	GO:0050890	149	0.149
erythrocyte differentiation	GO:0030218	88	0.148	Mouse
positive regulation of kinase activity	GO:0033674	155	0.148
regulation of lymphocyte apoptotic process	GO:0070228	41	0.146
jnk cascade	GO:0007254	72	0.146
negative regulation of toll like receptor signaling pathway	GO:0034122	14	0.145
negative regulation of growth	GO:0045926	99	0.145
peptidyl amino acid modification	GO:0018193	336	0.143
positive regulation of cell death	GO:0010942	224	0.142
cellular amino acid metabolic process	GO:0006520	103	0.142
anatomical structure homeostasis	GO:0060249	145	0.142
regulation of stress activated mapk cascade	GO:0032872	69	0.142
eosinophil activation involved in immune response	GO:0002278	1	0.141
positive regulation of mapk cascade	GO:0043410	170	0.141
wound healing	GO:0042060	157	0.140
cell substrate adhesion	GO:0031589	130	0.140
t cell receptor signaling pathway	GO:0050852	46	0.140
sequestering of metal ion	GO:0051238	19	0.139
synapse organization	GO:0050808	125	0.138
coagulation	GO:0050817	78	0.138
regulation of endocytosis	GO:0030100	69	0.137
regulation of protein kinase activity	GO:0045859	232	0.135
hemostasis	GO:0007599	78	0.134
response to lipopolysaccharide	GO:0032496	128	0.132
regulation of actin cytoskeleton organization	GO:0032956	84	0.130
fc receptor mediated inhibitory signaling pathway	GO:0002774	1	0.128
lymphocyte homeostasis	GO:0002260	64	0.128
actin cytoskeleton organization	GO:0030036	220	0.127
cell type specific apoptotic process	GO:0097285	268	0.127
positive regulation of t cell costimulation	GO:2000525	2	0.127
interferon beta biosynthetic process	GO:0045350	4	0.126
gliogenesis	GO:0042063	141	0.125
divalent inorganic cation transport	GO:0072511	178	0.125
regulation of asymmetric cell division	GO:0009786	4	0.125
t cell extravasation	GO:0072683	4	0.124
response to transforming growth factor beta	GO:0071559	88	0.123
developmental maturation	GO:0021700	193	0.123
learning or memory	GO:0007611	148	0.123
mast cell activation involved in immune response	GO:0002279	20	0.122
negative regulation of nervous system development	GO:0051961	156	0.122
positive regulation of leukocyte differentiation	GO:1902107	86	0.121
cytokine biosynthetic process	GO:0042089	68	0.121
germ cell development	GO:0007281	185	0.120
positive regulation of apoptotic process	GO:0043065	217	0.119
cytokine mediated signaling pathway	GO:0019221	115	0.119
positive regulation of cytokine secretion	GO:0050715	41	0.119
antigen processing and presentation	GO:0019882	47	0.119
regulation of inflammatory response	GO:0050727	147	0.119
angiogenesis	GO:0001525	201	0.118	Mouse
sensory perception	GO:0007600	245	0.117
regulation of ras protein signal transduction	GO:0046578	114	0.117
b cell receptor signaling pathway	GO:0050853	20	0.117
leukocyte activation involved in immune response	GO:0002366	126	0.116
cytokine metabolic process	GO:0042107	71	0.115
lymphocyte mediated immunity	GO:0002449	139	0.115
kidney development	GO:0001822	213	0.114
single organism cell adhesion	GO:0098602	156	0.114
regulation of cellular ketone metabolic process	GO:0010565	66	0.114
rho protein signal transduction	GO:0007266	32	0.113
regulation of leukocyte apoptotic process	GO:2000106	56	0.113
small molecule biosynthetic process	GO:0044283	132	0.112
cellular response to lipid	GO:0071396	145	0.112
regulation of podosome assembly	GO:0071801	3	0.111
organelle localization	GO:0051640	179	0.110
regulation of monocyte extravasation	GO:2000437	2	0.109
positive regulation of transferase activity	GO:0051347	167	0.109
positive regulation of cellular amine metabolic process	GO:0033240	5	0.109
stress activated mapk cascade	GO:0051403	80	0.108
protein secretion	GO:0009306	111	0.108
cellular ketone metabolic process	GO:0042180	84	0.108
regulation of cytokine secretion	GO:0050707	61	0.108
defense response to bacterium	GO:0042742	119	0.106
regulation of acute inflammatory response to antigenic stimulus	GO:0002864	10	0.105
regulation of mast cell activation involved in immune response	GO:0033006	17	0.105
positive regulation of mast cell activation involved in immune response	GO:0033008	10	0.105
positive regulation of immunological synapse formation	GO:2000522	1	0.104
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.103
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.103
negative regulation of intracellular signal transduction	GO:1902532	167	0.103
regulation of myeloid cell differentiation	GO:0045637	96	0.102	Zebrafish
regulation of binding	GO:0051098	111	0.102
humoral immune response	GO:0006959	57	0.101
regulation of t cell costimulation	GO:2000523	2	0.101
tissue homeostasis	GO:0001894	115	0.101
hematopoietic stem cell migration	GO:0035701	1	0.099
antigen processing and presentation of exogenous peptide antigen via mhc class ii	GO:0019886	14	0.098
regulation of cell projection organization	GO:0031344	206	0.098
regulation of acute inflammatory response	GO:0002673	27	0.098
response to growth factor	GO:0070848	198	0.098
thymic t cell selection	GO:0045061	22	0.097
regulation of phospholipase c activity	GO:1900274	3	0.097
response to peptide hormone	GO:0043434	127	0.097
cell activation involved in immune response	GO:0002263	126	0.097
platelet aggregation	GO:0070527	20	0.096
positive regulation of interferon alpha production	GO:0032727	4	0.096
regulation of canonical wnt signaling pathway	GO:0060828	82	0.095
negative regulation of molecular function	GO:0044092	258	0.095
regulation of leukocyte degranulation	GO:0043300	20	0.095
regulation of tumor necrosis factor superfamily cytokine production	GO:1903555	50	0.094
muscle tissue development	GO:0060537	308	0.094
establishment or maintenance of cell polarity	GO:0007163	86	0.093
regulation of t cell receptor signaling pathway	GO:0050856	21	0.093
positive regulation of jnk cascade	GO:0046330	46	0.093
multicellular organismal signaling	GO:0035637	91	0.093
response to testosterone	GO:0033574	3	0.093
response to interferon gamma	GO:0034341	34	0.092
regulation of t cell differentiation	GO:0045580	83	0.092
establishment of organelle localization	GO:0051656	122	0.091
regulation of body fluid levels	GO:0050878	162	0.091
cell growth	GO:0016049	130	0.091
positive regulation of immune effector process	GO:0002699	107	0.091
negative regulation of b cell activation	GO:0050869	27	0.091
leukocyte apoptotic process	GO:0071887	71	0.090
oligodendrocyte differentiation	GO:0048709	53	0.089
regulation of interleukin 8 production	GO:0032677	3	0.089
gland development	GO:0048732	330	0.088
regulation of hormone levels	GO:0010817	211	0.088
adenylate cyclase modulating g protein coupled receptor signaling pathway	GO:0007188	54	0.088
negative regulation of protein metabolic process	GO:0051248	282	0.088
regulation of cellular amine metabolic process	GO:0033238	20	0.087
regulation of calcium ion transport into cytosol	GO:0010522	31	0.087
learning	GO:0007612	98	0.087
sphingosine 1 phosphate signaling pathway	GO:0003376	3	0.087
negative regulation of cell development	GO:0010721	169	0.086
cellular response to biotic stimulus	GO:0071216	92	0.086
alpha beta t cell differentiation	GO:0046632	69	0.086
innate immune response activating signal transduction	GO:0002758	50	0.086
circulatory system process	GO:0003013	197	0.086
positive regulation of map kinase activity	GO:0043406	84	0.086
tumor necrosis factor superfamily cytokine production	GO:0071706	51	0.086
regulation of ion transport	GO:0043269	215	0.085
regulation of t cell extravasation	GO:2000407	3	0.085
cellular lipid metabolic process	GO:0044255	323	0.085
developmental cell growth	GO:0048588	84	0.084
response to acid chemical	GO:0001101	111	0.083
macromolecule catabolic process	GO:0009057	281	0.083
cell chemotaxis	GO:0060326	81	0.083
regulation of protein secretion	GO:0050708	82	0.082
sensory organ morphogenesis	GO:0090596	242	0.082
positive regulation of protein phosphorylation	GO:0001934	242	0.082
positive regulation of leukocyte apoptotic process	GO:2000108	21	0.081
interleukin 1 beta production	GO:0032611	30	0.081
negative regulation of response to wounding	GO:1903035	77	0.081
negative regulation of leukocyte proliferation	GO:0070664	46	0.081
regulation of interferon gamma production	GO:0032649	57	0.081
substrate adhesion dependent cell spreading	GO:0034446	30	0.081
regulation of actin filament based process	GO:0032970	99	0.080
neuron migration	GO:0001764	122	0.080
regulation of cytokine biosynthetic process	GO:0042035	59	0.080
leukocyte mediated immunity	GO:0002443	174	0.080
ensheathment of neurons	GO:0007272	76	0.079
myeloid cell activation involved in immune response	GO:0002275	34	0.079
regulation of hemostasis	GO:1900046	28	0.078
cell fate commitment	GO:0045165	210	0.078
regulation of neuron differentiation	GO:0045664	281	0.077
regulation of wound healing	GO:0061041	40	0.077
regulation of immune complex clearance by monocytes and macrophages	GO:0090264	2	0.077
mast cell proliferation	GO:0070662	4	0.077
lymphocyte migration	GO:0072676	26	0.076
regulation of transferase activity	GO:0051338	263	0.076
regulation of cytoskeleton organization	GO:0051493	122	0.076
homeostasis of number of cells	GO:0048872	210	0.076	Mouse
cellularization	GO:0007349	1	0.076
establishment of endothelial blood brain barrier	GO:0014045	3	0.075
cellular response to molecule of bacterial origin	GO:0071219	83	0.075
positive regulation of neuron differentiation	GO:0045666	141	0.075
organelle assembly	GO:0070925	177	0.075
organic acid biosynthetic process	GO:0016053	86	0.075
t helper 17 cell chemotaxis	GO:0035705	1	0.074
neural precursor cell proliferation	GO:0061351	121	0.074
regulation of t cell proliferation	GO:0042129	92	0.074
divalent metal ion transport	GO:0070838	172	0.074
toll like receptor signaling pathway	GO:0002224	38	0.074
positive regulation of protein transport	GO:0051222	93	0.074
tumor necrosis factor biosynthetic process	GO:0042533	10	0.073
telencephalon development	GO:0021537	186	0.073
phosphatidylinositol 3 kinase signaling	GO:0014065	36	0.073
protein methylation	GO:0006479	81	0.073
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.072
regulation of cellular amino acid metabolic process	GO:0006521	5	0.072
positive regulation of lymphocyte differentiation	GO:0045621	61	0.071
microtubule based process	GO:0007017	236	0.071
positive regulation of protein modification process	GO:0031401	299	0.071
positive regulation of cardioblast differentiation	GO:0051891	3	0.070
motor neuron axon guidance	GO:0008045	26	0.070
cellular response to growth factor stimulus	GO:0071363	197	0.069
positive regulation of protein kinase activity	GO:0045860	144	0.069
negative regulation of t cell proliferation	GO:0042130	38	0.069
microtubule cytoskeleton organization	GO:0000226	157	0.069
response to extracellular stimulus	GO:0009991	127	0.069
immune complex clearance	GO:0002434	2	0.069
positive regulation of regulated secretory pathway	GO:1903307	10	0.069
small gtpase mediated signal transduction	GO:0007264	97	0.067
epidermis development	GO:0008544	187	0.067
cardiac muscle tissue development	GO:0048738	130	0.067
phagocytosis	GO:0006909	66	0.067
ameboidal type cell migration	GO:0001667	128	0.067
leukocyte degranulation	GO:0043299	27	0.067
regulation of coagulation	GO:0050818	31	0.066
regulation of mast cell degranulation	GO:0043304	16	0.066
leukocyte homeostasis	GO:0001776	79	0.066
immune complex clearance by monocytes and macrophages	GO:0002436	2	0.066
positive regulation of cell adhesion	GO:0045785	80	0.066
wnt signaling pathway	GO:0016055	188	0.066
regulation of interleukin 1 production	GO:0032652	26	0.066
endomembrane system organization	GO:0010256	147	0.066
negative regulation of kinase activity	GO:0033673	81	0.066
intracellular receptor signaling pathway	GO:0030522	74	0.066
osteoclast differentiation	GO:0030316	62	0.065
microglia differentiation	GO:0014004	2	0.065
regulation of cd8 positive alpha beta t cell extravasation	GO:2000449	3	0.065
negative regulation of t cell activation	GO:0050868	65	0.065
carbohydrate homeostasis	GO:0033500	128	0.064
mitotic cell cycle process	GO:1903047	159	0.064
acute inflammatory response	GO:0002526	41	0.064
tumor necrosis factor production	GO:0032640	50	0.064
axon ensheathment	GO:0008366	76	0.064
myd88 independent toll like receptor signaling pathway	GO:0002756	3	0.063
regulation of b cell activation	GO:0050864	81	0.063
positive regulation of defense response	GO:0031349	124	0.063
positive regulation of cytosolic calcium ion concentration	GO:0007204	65	0.063
negative regulation of leukocyte differentiation	GO:1902106	51	0.062
positive regulation of tumor necrosis factor superfamily cytokine production	GO:1903557	31	0.062
regulation of lipid metabolic process	GO:0019216	118	0.062
mast cell mediated immunity	GO:0002448	20	0.061
regulation of intracellular transport	GO:0032386	159	0.061
regulation of antigen receptor mediated signaling pathway	GO:0050854	29	0.061
immunoglobulin mediated immune response	GO:0016064	69	0.061
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.061
positive regulation of wnt signaling pathway	GO:0030177	45	0.061
regulation of rho protein signal transduction	GO:0035023	71	0.060
negative regulation of cellular component organization	GO:0051129	194	0.060
transmission of nerve impulse	GO:0019226	76	0.060
positive regulation of neuron projection development	GO:0010976	79	0.060
branching involved in mammary gland duct morphogenesis	GO:0060444	27	0.060
regulation of tumor necrosis factor biosynthetic process	GO:0042534	10	0.060
stimulatory c type lectin receptor signaling pathway	GO:0002223	2	0.060
renal system development	GO:0072001	225	0.060
synaptic transmission	GO:0007268	329	0.059
myeloid leukocyte mediated immunity	GO:0002444	42	0.059
protein kinase b signaling	GO:0043491	74	0.059
glycoprotein metabolic process	GO:0009100	116	0.059
regulation of cell cycle process	GO:0010564	160	0.058
ossification	GO:0001503	216	0.058
oogenesis	GO:0048477	56	0.058
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	61	0.058
hormone secretion	GO:0046879	128	0.057
regulation of adaptive immune response	GO:0002819	90	0.057
carbohydrate transport	GO:0008643	62	0.057
positive regulation of tyrosine phosphorylation of stat5 protein	GO:0042523	6	0.057
neuronal action potential	GO:0019228	54	0.057
epithelial tube morphogenesis	GO:0060562	303	0.056	Mouse
regulation of epithelial cell proliferation	GO:0050678	141	0.056
cell recognition	GO:0008037	83	0.056
blood coagulation	GO:0007596	76	0.056
neurohypophysis development	GO:0021985	2	0.055
negative regulation of inflammatory response	GO:0050728	61	0.055
fc receptor mediated stimulatory signaling pathway	GO:0002431	4	0.055
negative regulation of erk1 and erk2 cascade	GO:0070373	21	0.055
positive regulation of exocytosis	GO:0045921	20	0.055
immune response inhibiting signal transduction	GO:0002765	4	0.055
muscle tissue morphogenesis	GO:0060415	53	0.055
regulation of platelet activation	GO:0010543	17	0.055
positive regulation of protein complex assembly	GO:0031334	45	0.054
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation	GO:2000526	1	0.054
inner ear morphogenesis	GO:0042472	101	0.054
positive regulation of phospholipase c activity	GO:0010863	2	0.054
eosinophil mediated immunity	GO:0002447	1	0.054
negative regulation of phosphate metabolic process	GO:0045936	184	0.053
regulated secretory pathway	GO:0045055	32	0.053
negative regulation of multi organism process	GO:0043901	68	0.053
phospholipid metabolic process	GO:0006644	87	0.053
response to ethanol	GO:0045471	18	0.053
canonical wnt signaling pathway	GO:0060070	130	0.052
positive regulation of purine nucleotide catabolic process	GO:0033123	88	0.052
cellular amine metabolic process	GO:0044106	44	0.052
mature dendritic cell differentiation	GO:0097029	3	0.052
positive regulation of acute inflammatory response	GO:0002675	16	0.052
positive regulation of interferon gamma production	GO:0032729	39	0.051
organelle fission	GO:0048285	170	0.051
regulation of exocytosis	GO:0017157	61	0.051
granulocyte chemotaxis	GO:0071621	39	0.051
negative regulation of myeloid leukocyte differentiation	GO:0002762	20	0.051
cell junction organization	GO:0034330	77	0.051
positive regulation of antigen receptor mediated signaling pathway	GO:0050857	9	0.051
extracellular structure organization	GO:0043062	148	0.051
regulation of ossification	GO:0030278	112	0.051
skin development	GO:0043588	220	0.051
positive regulation of t cell extravasation	GO:2000409	2	0.051
regulation of homotypic cell cell adhesion	GO:0034110	13	0.051
regulation of actin polymerization or depolymerization	GO:0008064	45	0.051
negative regulation of cytokine production	GO:0001818	84	0.050
digestive tract development	GO:0048565	190	0.050
metanephric loop of henle development	GO:0072236	4	0.050
regulation of protein catabolic process	GO:0042176	108	0.050
telencephalon cell migration	GO:0022029	55	0.050
negative regulation of phosphorylation	GO:0042326	166	0.049
regulation of vasculature development	GO:1901342	88	0.049
regulation of erythrocyte differentiation	GO:0045646	23	0.049
myeloid leukocyte migration	GO:0097529	57	0.049
interleukin 4 production	GO:0032633	24	0.049
positive regulation of stress activated mapk cascade	GO:0032874	48	0.049
oxidation reduction process	GO:0055114	342	0.049
positive regulation of organelle organization	GO:0010638	128	0.048
cellular extravasation	GO:0045123	17	0.048
positive regulation of b cell receptor signaling pathway	GO:0050861	4	0.048
positive regulation of hematopoietic stem cell migration	GO:2000473	1	0.047
cellular response to extracellular stimulus	GO:0031668	81	0.047
protein catabolic process	GO:0030163	221	0.046
insulin secretion	GO:0030073	89	0.046
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.046
digestive tract morphogenesis	GO:0048546	147	0.046
positive regulation of dendritic cell chemotaxis	GO:2000510	1	0.045
negative regulation of transferase activity	GO:0051348	85	0.045
microglia development	GO:0014005	2	0.045
release of sequestered calcium ion into cytosol	GO:0051209	42	0.045
t cell selection	GO:0045058	34	0.045
glial cell development	GO:0021782	54	0.045
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger	GO:0007187	55	0.044
negative regulation of mapk cascade	GO:0043409	65	0.044
formation of primary germ layer	GO:0001704	77	0.044
cell maturation	GO:0048469	127	0.044
negative regulation of map kinase activity	GO:0043407	34	0.044
nitrogen compound transport	GO:0071705	271	0.044
positive regulation of lymphocyte proliferation	GO:0050671	70	0.044
regulation of bone resorption	GO:0045124	24	0.043
regulation of dendritic cell apoptotic process	GO:2000668	3	0.043
regulation of blood pressure	GO:0008217	93	0.043
negative regulation of b cell proliferation	GO:0030889	13	0.043
regulation of jnk cascade	GO:0046328	62	0.043
cardiac muscle tissue growth involved in heart morphogenesis	GO:0003245	1	0.043
positive regulation of interleukin 8 secretion	GO:2000484	1	0.043
positive regulation of hydrolase activity	GO:0051345	148	0.042
regulation of calcium mediated signaling	GO:0050848	19	0.042
positive regulation of leukocyte proliferation	GO:0070665	73	0.042
regulation of synapse assembly	GO:0051963	29	0.042
protein autophosphorylation	GO:0046777	61	0.041

Spib disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
primary immunodeficiency disease	DOID:612	0.260
immune system disease	DOID:2914	0.260
disease of anatomical entity	DOID:7	0.260
blood protein disease	DOID:620	0.095
hematopoietic system disease	DOID:74	0.095
musculoskeletal system disease	DOID:17	0.042

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