Mus musculus

0 known processes

Gzmd

granzyme D

(Aliases: Ctla5,CCP5,Ctla-5)

Gzmd biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
positive regulation of transforming growth factor beta secretionGO:200120310.859
transforming growth factor beta secretionGO:003804410.709
regulation of transforming growth factor beta secretionGO:200120110.626
neutrophil mediated killing of gram positive bacteriumGO:007094620.598
Mouse
granzyme mediated apoptotic signaling pathwayGO:000862610.466
Mouse
regulation of interleukin 10 secretionGO:200117940.173
regulation of microvillus organizationGO:003253030.161
regulation of systemic arterial blood pressure mediated by a chemical signalGO:0003044330.154
Mouse
negative regulation of endothelial cell migrationGO:001059640.126
disruption of cells of other organism involved in symbiotic interactionGO:0051818130.125
Mouse
regulation of angiotensin metabolic processGO:006017740.125
Mouse
regulation of microvillus assemblyGO:003253430.114
regulation of blood pressureGO:0008217930.106
Mouse
cell adhesionGO:00071553290.103
lymphocyte mediated immunityGO:00024491390.092
Mouse
interleukin 10 secretionGO:007260840.087
regulation of angiotensin levels in bloodGO:000200240.075
Mouse
lipid biosynthetic processGO:00086101790.067
regulation of cellular ketone metabolic processGO:0010565660.060
defense response to gram positive bacteriumGO:0050830500.059
Mouse
adaptive immune responseGO:00022501550.054
Mouse
killing by host of symbiont cellsGO:0051873110.050
Mouse
cellular response to hormone stimulusGO:00328701500.049
spermatogenesisGO:00072832840.048
regulation of systemic arterial blood pressure by hormoneGO:0001990250.047
Mouse
t cell mediated cytotoxicityGO:0001913260.046
Mouse
cytokine productionGO:00018163190.046
cellular carbohydrate metabolic processGO:00442621190.045
negative regulation of blood vessel endothelial cell migrationGO:004353730.043
cellular response to organonitrogen compoundGO:00714171450.041
medium chain fatty acid metabolic processGO:005179110.041
regulation of kinase activityGO:00435492490.041
cellular ketone metabolic processGO:0042180840.041
calcitriol biosynthetic process from calciolGO:003637830.041
positive regulation of cellular amine metabolic processGO:003324050.040
response to nutrient levelsGO:00316671090.040
blood circulationGO:00080151950.040
Mouse
regulation of cell projection organizationGO:00313442060.039
stimulatory c type lectin receptor signaling pathwayGO:000222320.038
regulation of protein transportGO:00512231630.038
response to molecule of bacterial originGO:00022371430.037
Mouse
regulation of hydrolase activityGO:00513362460.036
response to lipopolysaccharideGO:00324961280.036
Mouse
protein catabolic processGO:00301632210.036
negative regulation of growth of symbiont involved in interaction with hostGO:0044146190.036
Mouse
regulation of hormone levelsGO:00108172110.035
Mouse
negative regulation of cellular protein metabolic processGO:00322692470.035
cell killingGO:0001906670.035
Mouse
response to inorganic substanceGO:0010035960.035
brown fat cell proliferationGO:007034210.035
cellular response to lipidGO:00713961450.035
immune effector processGO:00022523210.034
Mouse
cellular alcohol metabolic processGO:004410730.034
oxidation reduction processGO:00551143420.034
regulation of transferase activityGO:00513382630.033
fat cell differentiationGO:00454441600.033
male gamete generationGO:00482322850.032
defense response to bacteriumGO:00427421190.032
Mouse
growth of symbiont involved in interaction with hostGO:0044116230.032
Mouse
alcohol metabolic processGO:00060661160.031
myeloid leukocyte mediated immunityGO:0002444420.031
Mouse
negative regulation of protein metabolic processGO:00512482820.031
hormone metabolic processGO:0042445860.031
vitamin d3 metabolic processGO:007064030.030
organic hydroxy compound metabolic processGO:19016152030.030
regulation of cellular amine metabolic processGO:0033238200.030
myotube differentiationGO:00149021050.029
cytoplasmic transportGO:00164822340.029
midgut developmentGO:000749440.029
regulation of feeding behaviorGO:006025930.029
negative regulation of protein processingGO:0010955790.029
multicellular organism growthGO:00352641610.029
leukocyte mediated immunityGO:00024431740.029
Mouse
leukocyte mediated cytotoxicityGO:0001909620.028
Mouse
cellular amino acid metabolic processGO:00065201030.028
positive regulation of cytokine productionGO:00018191740.028
macromolecule catabolic processGO:00090572810.028
negative regulation of molecular functionGO:00440922580.028
negative regulation of phosphorylationGO:00423261660.028
disruption by host of symbiont cellsGO:0051852110.028
Mouse
cellular response to organic cyclic compoundGO:0071407870.027
regulation of systemic arterial blood pressure by circulatory renin angiotensinGO:0001991130.027
Mouse
regulation of establishment of protein localizationGO:00702011810.027
protein secretionGO:00093061110.027
protein maturationGO:00516041760.026
regulation of secretion by cellGO:19035302490.026
olfactory learningGO:000835520.026
response to organic cyclic compoundGO:00140701980.026
regulation of defense responseGO:00313472330.026
positive regulation of cell projection organizationGO:0031346950.025
negative regulation of protein phosphorylationGO:00019331260.025
regulation of lipid metabolic processGO:00192161180.025
endocrine processGO:0050886390.025
Mouse
regulation of angiogenesisGO:0045765810.025
negative regulation of phosphorus metabolic processGO:00105631840.025
nitrogen compound transportGO:00717052710.025
positive regulation of cellular amino acid metabolic processGO:004576430.024
organophosphate biosynthetic processGO:00904071220.024
regulation of protein localizationGO:00328802310.024
response to peptide hormoneGO:00434341270.024
axonogenesisGO:00074092740.024
carboxylic acid transportGO:00469421000.024
regulation of peptidase activityGO:0052547960.024
muscle tissue developmentGO:00605373080.023
organic anion transportGO:00157111370.023
regulation of brown fat cell proliferationGO:007034710.023
regulation of systemic arterial blood pressureGO:0003073610.022
Mouse
growth of symbiont in hostGO:0044117230.022
Mouse
cellular alcohol biosynthetic processGO:004410830.022
striated muscle tissue developmentGO:00147062930.022
regulation of proteolysisGO:00301621640.022
response to organonitrogen compoundGO:00102432460.022
transmembrane transportGO:00550854120.022
glucose metabolic processGO:0006006920.022
cellular nitrogen compound catabolic processGO:00442702800.022
regulation of cytokine productionGO:00018172660.022
circulatory system processGO:00030131970.022
Mouse
anion transportGO:00068201770.022
reactive nitrogen species metabolic processGO:200105700.022
sprouting angiogenesisGO:0002040260.021
regulation of systemic arterial blood pressure by renin angiotensinGO:0003081200.021
Mouse
negative regulation of protein modification processGO:00314001630.021
innate immune response activating cell surface receptor signaling pathwayGO:000222040.021
symbiosis encompassing mutualism through parasitismGO:0044403830.021
Mouse
positive regulation of natural killer cell mediated immunityGO:0002717160.020
protein modification by small protein conjugation or removalGO:00706472070.020
cellular protein catabolic processGO:00442571550.020
regulation of synaptic growth at neuromuscular junctionGO:000858240.020
placenta developmentGO:00018901400.020
regulation of secretionGO:00510462740.020
renal system process involved in regulation of blood volumeGO:000197740.020
monosaccharide metabolic processGO:00059961060.020
regulation of reactive oxygen species metabolic processGO:2000377400.020
g protein coupled receptor signaling pathwayGO:00071862430.020
defense response to other organismGO:00985421970.019
Mouse
regulation of symbiosis encompassing mutualism through parasitismGO:0043903520.019
Mouse
regulation of lipid biosynthetic processGO:0046890540.019
cell substrate adhesionGO:00315891300.019
organonitrogen compound biosynthetic processGO:19015661920.019
membrane organizationGO:00610242450.018
positive regulation of angiogenesisGO:0045766460.018
regulation of carbohydrate metabolic processGO:0006109750.018
dephosphorylationGO:00163111290.018
regulation of myotube differentiationGO:0010830620.018
purine ribonucleotide metabolic processGO:00091502900.018
response to steroid hormoneGO:0048545560.018
ribose phosphate metabolic processGO:00196932910.018
purine nucleotide metabolic processGO:00061633020.018
cellular response to peptide hormone stimulusGO:0071375920.018
organic hydroxy compound biosynthetic processGO:1901617770.018
muscle cell differentiationGO:00426922610.018
response to acid chemicalGO:00011011110.018
reactive oxygen species metabolic processGO:0072593840.018
cellular response to steroid hormone stimulusGO:0071383330.018
fat soluble vitamin biosynthetic processGO:004236240.018
inflammatory responseGO:00069542440.017
skin developmentGO:00435882200.017
glycerolipid metabolic processGO:00464861220.017
modification by host of symbiont morphology or physiologyGO:0051851120.017
Mouse
spermatid developmentGO:00072861080.017
protein processingGO:00164851630.017
amino acid transmembrane transportGO:0003333370.017
cellular response to lipopolysaccharideGO:0071222770.017
cytokine secretionGO:0050663720.017
reactive oxygen species biosynthetic processGO:190340980.017
negative regulation of phosphate metabolic processGO:00459361840.017
mapk cascadeGO:00001652810.017
negative regulation of feeding behaviorGO:200025210.017
peptidyl serine modificationGO:0018209830.017
protein modification by small protein conjugationGO:00324461870.017
cellular response to molecule of fungal originGO:007122620.017
regulation of cellular amino acid metabolic processGO:000652150.017
regulation of lymphocyte activationGO:00512492400.016
cellular response to molecule of bacterial originGO:0071219830.016
negative regulation of growthGO:0045926990.016
Mouse
small molecule biosynthetic processGO:00442831320.016
regulation of cellular carbohydrate metabolic processGO:0010675750.016
steroid metabolic processGO:00082021190.016
negative regulation of proteolysisGO:0045861740.016
secondary alcohol metabolic processGO:190265230.016
erk1 and erk2 cascadeGO:0070371770.016
small gtpase mediated signal transductionGO:0007264970.016
cellular amine metabolic processGO:0044106440.016
dna metabolic processGO:00062593030.016
cellular response to biotic stimulusGO:0071216920.016
neutrophil mediated cytotoxicityGO:007094280.016
Mouse
cellular macromolecule catabolic processGO:00442652060.016
carbohydrate metabolic processGO:00059752300.016
alcohol biosynthetic processGO:0046165430.016
neutrophil mediated immunityGO:0002446190.016
Mouse
proteolysis involved in cellular protein catabolic processGO:00516031470.016
disruption of cells of other organismGO:0044364130.015
Mouse
positive regulation of protein phosphorylationGO:00019342420.015
positive regulation of protein secretionGO:0050714520.015
energy derivation by oxidation of organic compoundsGO:0015980770.015
nuclear transportGO:00511691390.015
regulation of protein maturationGO:1903317960.015
positive regulation of secretionGO:00510471300.015
single fertilizationGO:0007338820.015
visual perceptionGO:0007601520.015
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.015
gonad developmentGO:00084061410.015
organic acid transportGO:00158491010.015
regulation of protein secretionGO:0050708820.015
growth involved in symbiotic interactionGO:0044110230.015
Mouse
androgen biosynthetic processGO:000670240.015
angiogenesisGO:00015252010.015
cellular response to dna damage stimulusGO:00069742070.015
positive regulation of innate immune responseGO:0045089800.015
negative regulation of cell proliferationGO:00082852960.015
regulation of endopeptidase activityGO:0052548890.015
modification dependent protein catabolic processGO:00199411330.015
positive regulation of defense responseGO:00313491240.015
calcium ion dependent exocytosisGO:0017156350.014
regulation of innate immune responseGO:0045088910.014
response to oxidative stressGO:00069791230.014
glycerolipid biosynthetic processGO:0045017500.014
cellular response to peptideGO:1901653920.014
response to vitamin dGO:003328030.014
regulation of skeletal muscle fiber developmentGO:0048742360.014
anatomical structure homeostasisGO:00602491450.014
digestive system developmentGO:00551232000.014
skeletal muscle organ developmentGO:00605381630.014
t cell mediated immunityGO:0002456500.014
Mouse
organic cyclic compound catabolic processGO:19013612950.014
positive regulation of protein transportGO:0051222930.014
segmentationGO:0035282930.014
organelle localizationGO:00516401790.014
renal system processGO:0003014480.014
regulation of system processGO:00440572000.014
regulation of cell migrationGO:00303342190.014
positive regulation of immune effector processGO:00026991070.014
apoptotic signaling pathwayGO:00971903060.014
Mouse
hexose metabolic processGO:0019318980.014
positive regulation of secretion by cellGO:19035321140.014
response to peptideGO:19016521360.014
posttranscriptional regulation of gene expressionGO:00106081550.014
oocyte constructionGO:000730820.014
rhodopsin mediated signaling pathwayGO:001605640.014
negative regulation of protein maturationGO:1903318790.014
regulation of protein processingGO:0070613960.014
actin mediated cell contractionGO:0070252150.014
c21 steroid hormone biosynthetic processGO:000670030.014
negative regulation of growth of symbiont in hostGO:0044130190.014
Mouse
sympathetic neuron projection guidanceGO:009749140.013
regulation of reactive oxygen species biosynthetic processGO:190342620.013
regulation of body fluid levelsGO:00508781620.013
carbohydrate biosynthetic processGO:0016051740.013
regulation of nucleotide metabolic processGO:00061401690.013
ear morphogenesisGO:00424711180.013
regulation of protein serine threonine kinase activityGO:00719001570.013
regulation of cell motilityGO:20001452360.013
regulation of anatomical structure sizeGO:00900661780.013
response to oxygen levelsGO:0070482620.013
regulation of cell activationGO:00508652890.013
ribonucleoside metabolic processGO:00091192450.013
lipid transportGO:0006869980.013
carbohydrate derivative biosynthetic processGO:19011371830.013
vitamin d biosynthetic processGO:004236830.013
cellular lipid metabolic processGO:00442553230.013
endocytosisGO:00068971680.013
stem cell proliferationGO:00720891170.013
positive regulation of neuron differentiationGO:00456661410.013
purine nucleoside triphosphate metabolic processGO:00091442260.013
sperm motilityGO:0030317470.013
defense response to fungusGO:0050832120.013
Mouse
epidermis developmentGO:00085441870.013
protein ubiquitinationGO:00165671710.013
regionalizationGO:00030023370.013
negative regulation of insulin secretion involved in cellular response to glucose stimulusGO:006117940.013
negative regulation of cellular amine metabolic processGO:003323910.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.013
Mouse
neutrophil mediated killing of bacteriumGO:007094460.013
Mouse
endomembrane system organizationGO:00102561470.013
sulfur compound metabolic processGO:00067901000.013
regulation of cellular component biogenesisGO:00440871810.012
mesodermal cell migrationGO:000807840.012
regulation of homeostatic processGO:00328441820.012
fertilizationGO:00095661270.012
regulation of response to woundingGO:19030341890.012
positive regulation of cell developmentGO:00107202370.012
purine nucleoside metabolic processGO:00422782410.012
carbohydrate derivative catabolic processGO:19011362310.012
innate immune response activating signal transductionGO:0002758500.012
regulation of muscle system processGO:0090257800.012
isoprenoid metabolic processGO:0006720290.012
aromatic compound catabolic processGO:00194392860.012
regulation of vasculature developmentGO:1901342880.012
regulation of protein catabolic processGO:00421761080.012
response to drugGO:0042493750.012
negative regulation of brown fat cell proliferationGO:007034810.012
plasma membrane organizationGO:0007009900.012
multicellular organismal signalingGO:0035637910.012
gland developmentGO:00487323300.012
neutrophil mediated killing of symbiont cellGO:007094380.012
Mouse
positive regulation of natural killer cell mediated cytotoxicityGO:0045954160.012
amine metabolic processGO:0009308450.012
negative regulation of muscle cell differentiationGO:0051148330.012
sterol homeostasisGO:0055092450.012
nucleoside triphosphate catabolic processGO:00091432050.012
response to molecule of fungal originGO:000223840.012
negative regulation of hydrolase activityGO:0051346710.012
fat cell proliferationGO:007034140.012
response to extracellular stimulusGO:00099911270.012
regulation of action potentialGO:009890040.012
generation of precursor metabolites and energyGO:00060911030.012
ion transmembrane transportGO:00342203610.012
regulation of myoblast differentiationGO:0045661290.012
cell type specific apoptotic processGO:00972852680.012
maintenance of locationGO:0051235890.012
compound eye developmentGO:004874910.012
nucleoside metabolic processGO:00091162460.012
regulation of cellular response to stressGO:00801351590.012
regulation of erk1 and erk2 cascadeGO:0070372710.011
negative regulation of angiogenesisGO:0016525250.011
positive regulation of transferase activityGO:00513471670.011
regulation of cytoplasmic transportGO:19036491120.011
positive regulation of endothelial cell migrationGO:0010595120.011
substrate dependent cerebral cortex tangential migrationGO:002182530.011
single organism nuclear importGO:1902593950.011
negative regulation of lymphocyte activationGO:0051250910.011
proteasomal protein catabolic processGO:0010498980.011
regulation of tube sizeGO:0035150570.011
camera type eye developmentGO:00430102660.011
sa node cell action potentialGO:008601540.011
actin filament based movementGO:0030048230.011
developmental maturationGO:00217001930.011
peptide metabolic processGO:0006518460.011
positive regulation of inositol phosphate biosynthetic processGO:006073220.011
establishment of protein localization to organelleGO:00725941180.011
positive regulation of kinase activityGO:00336741550.011
cellular homeostasisGO:00197252400.011
oocyte axis specificationGO:000730920.011
antimicrobial peptide biosynthetic processGO:000277720.011
nucleotide metabolic processGO:00091173320.011
cell maturationGO:00484691270.011
regulation of striated muscle cell differentiationGO:0051153810.011
insulin receptor signaling pathwayGO:0008286490.011
cardiac muscle cell contractionGO:008600370.011
response to light stimulusGO:00094161350.011
regulation of hippo signalingGO:003533010.011
spermatid differentiationGO:00485151150.011
interferon gamma productionGO:0032609670.011
feeding behaviorGO:0007631620.011
progesterone metabolic processGO:004244840.011
purine ribonucleotide catabolic processGO:00091542080.011
nucleobase containing small molecule metabolic processGO:00550863520.011
positive regulation of reactive oxygen species biosynthetic processGO:190342820.011
positive regulation of hydrolase activityGO:00513451480.011
amino acid transportGO:0006865610.011
transmission of nerve impulseGO:0019226760.011
cellular response to acid chemicalGO:0071229680.011
myoblast differentiationGO:0045445520.011
peptide secretionGO:00027901140.011
protein localization to organelleGO:00333651850.011
heterocycle catabolic processGO:00467002800.011
positive regulation of cytokine secretionGO:0050715410.011
homeostasis of number of cellsGO:00488722100.011
response to testosteroneGO:003357430.011
trunk segmentationGO:003529040.011
nuclear divisionGO:00002801580.011
glycosyl compound metabolic processGO:19016572460.011
negative regulation of mitotic cell cycleGO:0045930580.011
positive regulation of nervous system developmentGO:00519622210.011
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.011
peptidyl serine phosphorylationGO:0018105740.011
ubiquitin dependent protein catabolic processGO:00065111290.011
skeletal muscle fiber developmentGO:0048741580.011
natural killer cell activationGO:0030101440.011
response to amino acidGO:0043200370.010
regulation of peptidyl tyrosine phosphorylationGO:0050730930.010
purine ribonucleoside catabolic processGO:00461302050.010
cellular response to external stimulusGO:0071496880.010
regulation of mapk cascadeGO:00434082480.010
anion transmembrane transportGO:0098656710.010
positive regulation of reactive oxygen species metabolic processGO:2000379110.010
purine ribonucleoside metabolic processGO:00461282410.010
cholesterol homeostasisGO:0042632440.010
intracellular protein transportGO:00068862040.010
glycoprotein metabolic processGO:00091001160.010
positive regulation of proteolysisGO:0045862850.010
response to retinoic acidGO:0032526560.010
positive regulation of protein kinase activityGO:00458601440.010
blood coagulationGO:0007596760.010
modification dependent macromolecule catabolic processGO:00436321330.010
monosaccharide transportGO:0015749580.010
detection of stimulusGO:0051606840.010
cell cell adhesion via plasma membrane adhesion moleculesGO:0098742400.010
positive regulation of protein modification processGO:00314012990.010

Gzmd disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.026
disease of anatomical entityDOID:700.026
central nervous system diseaseDOID:33100.021
neurodegenerative diseaseDOID:128900.018
sensory system diseaseDOID:005015500.015
cardiovascular system diseaseDOID:128700.015
eye and adnexa diseaseDOID:149200.014
eye diseaseDOID:561400.014
retinal diseaseDOID:567900.014
disease of metabolismDOID:001466700.013
retinal degenerationDOID:846600.011
amyotrophic lateral sclerosisDOID:33200.011
motor neuron diseaseDOID:23100.011