Mus musculus

41 known processes

Btk

Bruton agammaglobulinemia tyrosine kinase

(Aliases: AI528679,xid)

Btk biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
b cell activationGO:00421131610.999
Mouse
positive regulation of mapk cascadeGO:00434101700.992
Mouse
positive regulation of b cell proliferationGO:0030890240.991
b cell proliferationGO:0042100530.988
Mouse
negative regulation of phosphorus metabolic processGO:00105631840.985
Mouse
interleukin 5 secretionGO:007260320.975
immune effector processGO:00022523210.973
Mouse Rat
t cell proliferationGO:00420981200.972
Mouse
b cell receptor signaling pathwayGO:0050853200.961
Mouse
immune response activating signal transductionGO:00027571160.935
Mouse
adaptive immune responseGO:00022501550.934
Mouse
positive regulation of t cell activationGO:00508701010.928
Mouse
defense response to gram positive bacteriumGO:0050830500.925
Mouse
protein secretionGO:00093061110.916
Mouse
mapk cascadeGO:00001652810.905
Mouse
regulation of cell activationGO:00508652890.904
Mouse
interleukin 10 secretionGO:007260840.903
negative regulation of zinc ion transmembrane transportGO:007158320.902
leukocyte mediated immunityGO:00024431740.897
Mouse Rat
erk1 and erk2 cascadeGO:0070371770.875
Mouse
positive regulation of cytokine productionGO:00018191740.872
Mouse
positive regulation of cytokine biosynthetic processGO:0042108400.855
regulation of lymphocyte activationGO:00512492400.853
Mouse
amine metabolic processGO:0009308450.849
regulation of b cell differentiationGO:0045577230.843
regulation of cellular ketone metabolic processGO:0010565660.843
regulation of t cell proliferationGO:0042129920.842
regulation of neutrophil differentiationGO:004565820.839
positive regulation of map kinase activityGO:0043406840.839
regulation of b cell activationGO:0050864810.835
Mouse
immune response activating cell surface receptor signaling pathwayGO:0002429720.828
Mouse
regulation of cytokine biosynthetic processGO:0042035590.826
cytokine biosynthetic processGO:0042089680.823
positive regulation of secretion by cellGO:19035321140.821
Mouse
lymphocyte differentiationGO:00300982420.819
Mouse
myeloid cell differentiationGO:00300992330.818
Mouse
positive regulation of fatty acid transportGO:200019380.802
positive regulation of cell activationGO:00508671580.796
Mouse
defense response to bacteriumGO:00427421190.776
Mouse
ras protein signal transductionGO:0007265770.774
regulation of lipid transportGO:0032368360.769
cellular amine metabolic processGO:0044106440.769
neutrophil differentiationGO:003022330.766
regulation of lymphocyte proliferationGO:00506701170.760
Mouse
regulation of t cell activationGO:00508631700.758
Mouse
response to molecule of bacterial originGO:00022371430.758
Mouse
cellular response to cytokine stimulusGO:00713451890.743
positive regulation of lipid transportGO:0032370220.740
regulation of map kinase activityGO:00434051200.738
Mouse
regulation of tumor necrosis factor biosynthetic processGO:0042534100.737
positive regulation of transferase activityGO:00513471670.722
Mouse
toll like receptor signaling pathwayGO:0002224380.721
Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.718
activation of immune responseGO:00022531380.709
Mouse
bone resorptionGO:0045453380.708
Mouse
cellular ketone metabolic processGO:0042180840.700
anatomical structure homeostasisGO:00602491450.692
Mouse
regulation of leukocyte proliferationGO:00706631210.683
Mouse
defense response to other organismGO:00985421970.681
Mouse
positive regulation of lymphocyte proliferationGO:0050671700.680
positive regulation of b cell activationGO:0050871490.677
regulation of b cell proliferationGO:0030888390.674
Mouse
positive regulation of secretionGO:00510471300.671
Mouse
cytokine productionGO:00018163190.651
Mouse
humoral immune response mediated by circulating immunoglobulinGO:0002455140.650
positive regulation of adaptive immune responseGO:0002821610.640
regulation of hydrolase activityGO:00513362460.617
Mouse
regulation of mapk cascadeGO:00434082480.604
Mouse
positive regulation of leukocyte proliferationGO:0070665730.596
cellular response to biotic stimulusGO:0071216920.595
Mouse Rat
antigen receptor mediated signaling pathwayGO:0050851640.593
Mouse
lymph node developmentGO:0048535180.577
tyrosine phosphorylation of stat proteinGO:0007260230.574
Mouse
myeloid leukocyte differentiationGO:00025731190.563
Mouse
cellular amino acid metabolic processGO:00065201030.556
cellular response to lipopolysaccharideGO:0071222770.553
Mouse
immune response regulating cell surface receptor signaling pathwayGO:0002768800.548
Mouse
regulation of antigen receptor mediated signaling pathwayGO:0050854290.548
Mouse
icosanoid transportGO:0071715140.546
small gtpase mediated signal transductionGO:0007264970.544
regulation of cellular amino acid metabolic processGO:000652150.539
positive regulation of cellular amine metabolic processGO:003324050.538
monosaccharide metabolic processGO:00059961060.533
regulation of reactive oxygen species metabolic processGO:2000377400.532
negative regulation of growthGO:0045926990.531
Mouse
cytokine production involved in immune responseGO:0002367340.527
hexose metabolic processGO:0019318980.527
calcium ion homeostasisGO:00550741270.524
Mouse
regulation of leukocyte differentiationGO:19021051590.522
Mouse
positive regulation of myeloid leukocyte differentiationGO:0002763260.522
cytokine secretionGO:0050663720.517
Mouse
cytoplasmic transportGO:00164822340.515
Mouse
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.509
regulation of innate immune responseGO:0045088910.507
Mouse
glial cell apoptotic processGO:003434930.507
regulation of protein localizationGO:00328802310.498
Mouse
negative regulation of b cell proliferationGO:0030889130.491
Mouse
regulation of epidermal growth factor receptor signaling pathwayGO:0042058130.489
regulation of interleukin 13 secretionGO:200066520.488
cellular calcium ion homeostasisGO:00068741190.486
Mouse
cellular homeostasisGO:00197252400.484
Mouse
regulation of interleukin 5 secretionGO:200066220.483
lymphocyte proliferationGO:00466511640.474
Mouse
defense response to virusGO:0051607680.465
interferon gamma productionGO:0032609670.461
Mouse
activation of innate immune responseGO:0002218560.458
Mouse
ribonucleoside catabolic processGO:00424542060.453
cation transportGO:00068123990.452
Mouse Rat
extracellular matrix organizationGO:00301981470.451
tissue homeostasisGO:00018941150.451
Mouse
regulation of anatomical structure sizeGO:00900661780.447
Fly
ribonucleoside metabolic processGO:00091192450.446
activation of mapk activityGO:0000187590.446
positive regulation of leukocyte differentiationGO:1902107860.445
Mouse
negative regulation of cellular amine metabolic processGO:003323910.441
regulation of secretionGO:00510462740.440
Mouse
regulation of multi organism processGO:00439001110.436
regulation of protein kinase activityGO:00458592320.432
Mouse
osteoclast differentiationGO:0030316620.429
Mouse
somatic diversification of immune receptorsGO:0002200530.429
regulation of interleukin 6 productionGO:0032675550.427
regulation of cellular amine metabolic processGO:0033238200.425
regulation of lymphocyte differentiationGO:00456191070.421
Mouse
striated muscle cell developmentGO:00550021250.420
innate immune response activating signal transductionGO:0002758500.416
Mouse
response to organonitrogen compoundGO:00102432460.411
negative regulation of cellular amino acid metabolic processGO:004576300.406
positive regulation of ion transportGO:0043270650.397
humoral immune responseGO:0006959570.394
rho protein signal transductionGO:0007266320.393
transmembrane transportGO:00550854120.387
negative regulation of intracellular signal transductionGO:19025321670.387
Mouse
leukocyte proliferationGO:00706611720.383
Mouse
regulation of defense responseGO:00313472330.383
Mouse
synapse organizationGO:00508081250.382
metal ion homeostasisGO:00550651890.376
Mouse
cellular ion homeostasisGO:00068731650.373
Mouse
regulation of transferase activityGO:00513382630.372
Mouse
regulation of cell migrationGO:00303342190.369
Mouse
somatic diversification of immunoglobulins involved in immune responseGO:0002208360.364
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.360
regulation of myeloid cell differentiationGO:0045637960.359
Mouse
cellular metal ion homeostasisGO:00068751510.354
Mouse
regulation of cytokine secretion involved in immune responseGO:000273940.353
positive regulation of humoral immune responseGO:0002922110.353
guanosine containing compound metabolic processGO:19010681440.351
phosphatidylinositol biosynthetic processGO:0006661150.347
myeloid leukocyte activationGO:0002274830.346
Mouse Rat
cellular divalent inorganic cation homeostasisGO:00725031270.342
Mouse
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630570.341
production of molecular mediator of immune responseGO:00024401030.339
stress activated protein kinase signaling cascadeGO:0031098810.337
positive regulation of myoblast differentiationGO:004566380.336
homeostasis of number of cellsGO:00488722100.335
Mouse
regulation of cytokine productionGO:00018172660.335
Mouse
negative regulation of adaptive immune responseGO:0002820250.332
hemostasisGO:0007599780.327
Mouse
gtp metabolic processGO:00460391440.323
regulation of secretion by cellGO:19035302490.322
Mouse
t cell differentiationGO:00302171740.322
Mouse
alpha beta t cell differentiationGO:0046632690.321
Mouse
response to lipopolysaccharideGO:00324961280.321
Mouse
mast cell activationGO:0045576270.319
Mouse Rat
jak stat cascadeGO:0007259420.319
Mouse
g protein coupled receptor signaling pathwayGO:00071862430.315
negative regulation of lymphocyte proliferationGO:0050672450.309
Mouse
regulation of zinc ion transportGO:007157920.307
negative regulation of interleukin 13 secretionGO:200066610.306
interleukin 12 productionGO:0032615320.306
nucleoside triphosphate metabolic processGO:00091412300.305
divalent inorganic cation homeostasisGO:00725071380.305
Mouse
positive regulation of erk1 and erk2 cascadeGO:0070374470.301
Mouse
protein kinase b signalingGO:0043491740.301
glycosyl compound catabolic processGO:19016582060.299
pattern recognition receptor signaling pathwayGO:0002221470.297
Mouse
myd88 independent toll like receptor signaling pathwayGO:000275630.293
carboxylic acid transportGO:00469421000.293
cellular chemical homeostasisGO:00550822150.290
Mouse
negative regulation of zinc ion transportGO:007158220.289
regulation of membrane potentialGO:00423911920.287
nucleoside triphosphate catabolic processGO:00091432050.284
positive regulation of gtp catabolic processGO:0033126850.284
regulation of cell sizeGO:0008361720.283
purine ribonucleotide catabolic processGO:00091542080.282
monocarboxylic acid transportGO:0015718440.278
regulation of stress activated mapk cascadeGO:0032872690.277
positive regulation of cell deathGO:00109422240.271
Mouse
coagulationGO:0050817780.269
Mouse
positive regulation of interleukin 12 productionGO:0032735210.269
negative regulation of protein serine threonine kinase activityGO:0071901490.268
Mouse
positive regulation of lymphocyte differentiationGO:0045621610.261
Mouse
phospholipid metabolic processGO:0006644870.259
Mouse
cellular response to lipidGO:00713961450.259
Mouse
carbohydrate metabolic processGO:00059752300.258
regulation of zinc ion transmembrane transportGO:007158020.257
nucleoside phosphate catabolic processGO:19012922220.255
positive regulation of cellular amino acid metabolic processGO:004576430.254
positive regulation of defense responseGO:00313491240.245
Mouse
negative regulation of epidermal growth factor receptor signaling pathwayGO:004205960.245
positive regulation of jnk cascadeGO:0046330460.240
positive regulation of cell motilityGO:20001471160.238
Mouse
regulation of inflammatory response to antigenic stimulusGO:0002861210.238
positive regulation of protein phosphorylationGO:00019342420.237
Mouse
ribonucleotide metabolic processGO:00092592910.235
purine nucleoside metabolic processGO:00422782410.234
b cell homeostasisGO:0001782340.234
Mouse
cation homeostasisGO:00550802120.231
Mouse
regulation of response to woundingGO:19030341890.230
Mouse
growth of symbiont in hostGO:0044117230.229
regulation of chemokine productionGO:0032642300.228
dna metabolic processGO:00062593030.225
Fly
intracellular protein transportGO:00068862040.224
regulation of cellular component sizeGO:00325351210.221
Fly
negative regulation of odontogenesisGO:004248330.220
extrinsic apoptotic signaling pathwayGO:00971911260.219
positive regulation of protein serine threonine kinase activityGO:00719021060.219
organophosphate catabolic processGO:00464342320.218
positive regulation of myeloid cell differentiationGO:0045639430.218
lymphocyte mediated immunityGO:00024491390.217
cytokine mediated signaling pathwayGO:00192211150.216
reactive oxygen species metabolic processGO:0072593840.214
positive regulation of lymphocyte activationGO:00512511400.213
Mouse
syncytium formationGO:0006949430.213
positive regulation of jak stat cascadeGO:0046427220.211
Mouse
phosphatidylinositol 3 phosphate biosynthetic processGO:003609260.211
positive regulation of cytokine secretionGO:0050715410.210
Mouse
wound healingGO:00420601570.207
Mouse
transition metal ion transportGO:0000041380.203
leukocyte chemotaxisGO:0030595690.203
i kappab kinase nf kappab signalingGO:0007249850.202
regulation of ion transportGO:00432692150.201
Mouse
regulation of erk1 and erk2 cascadeGO:0070372710.201
Mouse
dna alkylationGO:0006305430.199
ossificationGO:00015032160.198
regulation of interleukin 10 productionGO:0032653210.197
positive regulation of t cell differentiationGO:0045582520.190
Mouse
b cell differentiationGO:0030183780.190
cell chemotaxisGO:0060326810.188
chemotaxisGO:00069352470.187
nucleoside phosphate metabolic processGO:00067533380.187
glycerolipid biosynthetic processGO:0045017500.186
regulation of interleukin 10 secretionGO:200117940.183
ribonucleotide catabolic processGO:00092612080.183
gtp catabolic processGO:00061841430.183
erbb signaling pathwayGO:0038127320.182
positive regulation of cell developmentGO:00107202370.182
Mouse
gland developmentGO:00487323300.181
Mouse Fly
regulation of alpha beta t cell proliferationGO:0046640180.181
positive regulation of cell migrationGO:00303351090.181
Mouse
negative regulation of mapk cascadeGO:0043409650.181
Mouse
positive regulation of interferon alpha productionGO:003272740.179
regulation of organic acid transportGO:0032890160.178
regulation of icosanoid secretionGO:003230380.177
regulation of sequence specific dna binding transcription factor activityGO:00510901060.176
regulation of mast cell degranulationGO:0043304160.175
Mouse
cdc42 protein signal transductionGO:003248800.174
positive regulation of immune effector processGO:00026991070.173
Mouse
positive regulation of homeostatic processGO:0032846640.172
positive regulation of protein modification processGO:00314012990.171
Mouse
positive regulation of protein secretionGO:0050714520.170
Mouse
dendrite developmentGO:00163581150.170
Mouse
peptidyl amino acid modificationGO:00181933360.170
positive regulation of intracellular transportGO:0032388700.169
Mouse
positive regulation of fever generation by positive regulation of prostaglandin secretionGO:007181220.169
regulation of interleukin 6 biosynthetic processGO:0045408110.169
regulation of alpha beta t cell activationGO:0046634530.169
purine containing compound metabolic processGO:00725213110.169
syncytium formation by plasma membrane fusionGO:0000768420.169
negative regulation of erbb signaling pathwayGO:190118570.168
nucleoside catabolic processGO:00091642060.167
multicellular organismal signalingGO:0035637910.167
purine nucleotide metabolic processGO:00061633020.165
glycerophospholipid biosynthetic processGO:0046474320.162
positive regulation of alpha beta t cell differentiationGO:0046638280.161
lipid modificationGO:0030258650.160
Mouse
nucleotide catabolic processGO:00091662170.160
nitrogen compound transportGO:00717052710.159
Rat
nucleoside metabolic processGO:00091162460.159
calcium mediated signalingGO:0019722460.157
positive regulation of protein kinase activityGO:00458601440.157
regulation of kinase activityGO:00435492490.157
Mouse
positive regulation of interleukin 18 productionGO:003274120.156
positive regulation of protein transportGO:0051222930.156
Mouse
cellular response to external stimulusGO:0071496880.156
negative regulation of secretionGO:0051048610.156
regulation of cytokine production involved in immune responseGO:0002718260.156
somatic recombination of immunoglobulin genes involved in immune responseGO:0002204360.155
regulation of alpha beta t cell differentiationGO:0046637350.154
ion transmembrane transportGO:00342203610.152
negative regulation of hydrolase activityGO:0051346710.151
multicellular organismal homeostasisGO:00488711640.151
Mouse
regulation of inflammatory responseGO:00507271470.151
Mouse
interleukin 18 productionGO:003262140.150
proteolysis involved in cellular protein catabolic processGO:00516031470.150
negative regulation of interleukin 13 productionGO:003269620.147
zinc ion transportGO:0006829120.147
purine ribonucleotide metabolic processGO:00091502900.146
divalent metal ion transportGO:00708381720.146
Mouse
regulation of cellular catabolic processGO:00313292420.145
glycerolipid metabolic processGO:00464861220.144
Mouse
regulation of actin polymerization or depolymerizationGO:0008064450.144
Fly
regulation of protein secretionGO:0050708820.143
Mouse
purine nucleoside catabolic processGO:00061522050.143
regulation of interleukin 12 productionGO:0032655300.141
purine ribonucleoside triphosphate catabolic processGO:00092071990.140
regulation of osteoclast differentiationGO:0045670360.140
axonogenesisGO:00074092740.139
regulation of tumor necrosis factor productionGO:0032680490.139
negative regulation of ras protein signal transductionGO:0046580180.139
negative regulation of t cell proliferationGO:0042130380.138
regulation of organelle organizationGO:00330432890.138
Mouse Fly
negative regulation of cell proliferationGO:00082852960.137
Mouse
leukocyte differentiationGO:00025213420.136
Mouse
developmental cell growthGO:0048588840.136
negative regulation of cellular protein metabolic processGO:00322692470.135
Mouse
acid secretionGO:0046717330.135
leukocyte migrationGO:00509001240.133
lipid transportGO:0006869980.132
mitotic cell cycleGO:00002781950.132
inorganic cation transmembrane transportGO:00986622070.132
glucose metabolic processGO:0006006920.132
neutrophil chemotaxisGO:0030593360.130
positive regulation of interleukin 6 productionGO:0032755370.130
dna methylationGO:0006306430.130
translational initiationGO:0006413240.129
ribonucleoside triphosphate metabolic processGO:00091992200.128
regulation of apoptotic signaling pathwayGO:20012331970.128
action potentialGO:0001508780.127
regulation of cell cycleGO:00517262810.127
regulation of gtp catabolic processGO:00331241130.127
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002824610.126
posttranscriptional regulation of gene expressionGO:00106081550.124
positive regulation of cytosolic calcium ion concentrationGO:0007204650.124
Mouse
regulation of protein serine threonine kinase activityGO:00719001570.124
Mouse
nucleotide metabolic processGO:00091173320.123
aromatic compound catabolic processGO:00194392860.123
tumor necrosis factor superfamily cytokine productionGO:0071706510.122
response to peptide hormoneGO:00434341270.122
granulocyte differentiationGO:0030851170.122
regulation of type 2 immune responseGO:0002828180.121
positive regulation of rac gtpase activityGO:0032855140.121
b cell activation involved in immune responseGO:0002312500.121
cognitionGO:00508901490.121
Fly
negative regulation of molecular functionGO:00440922580.119
Mouse
regulation of cell motilityGO:20001452360.119
Mouse
epidermal growth factor receptor signaling pathwayGO:0007173280.119
positive regulation of purine nucleotide catabolic processGO:0033123880.118
positive regulation of alpha beta t cell activationGO:0046635390.116
cellular response to peptidoglycanGO:007122440.115
cytokine metabolic processGO:0042107710.114
positive regulation of fever generationGO:003162260.114
regulation of organ growthGO:0046620610.113
immunoglobulin mediated immune responseGO:0016064690.111
positive regulation of t cell proliferationGO:0042102520.111
icosanoid secretionGO:0032309120.111
immunoglobulin secretionGO:0048305170.111
ensheathment of neuronsGO:0007272760.110
regulation of myotube differentiationGO:0010830620.110
negative regulation of growth of symbiont in hostGO:0044130190.108
positive regulation of nucleoside metabolic processGO:0045979910.108
t helper 2 cell differentiationGO:0045064120.108
isotype switchingGO:0045190360.107
second messenger mediated signalingGO:0019932730.107
positive regulation of nf kappab transcription factor activityGO:0051092300.107
dna hypomethylationGO:004402810.107
positive regulation of cytokine secretion involved in immune responseGO:000274120.107
circadian temperature homeostasisGO:006008620.107
ribonucleoside triphosphate catabolic processGO:00092031990.107
granulocyte activationGO:0036230100.106
purine nucleoside triphosphate metabolic processGO:00091442260.105
positive regulation of kinase activityGO:00336741550.104
Mouse
positive regulation of cellular catabolic processGO:00313311480.103
organic hydroxy compound metabolic processGO:19016152030.103
regulation of nucleotide binding oligomerization domain containing 1 signaling pathwayGO:007042830.102
regulation of cellular response to stressGO:00801351590.102
jnk cascadeGO:0007254720.102
tumor necrosis factor biosynthetic processGO:0042533100.101
regulation of ras protein signal transductionGO:00465781140.101
positive regulation of lymphocyte migrationGO:2000403110.101
epithelial tube morphogenesisGO:00605623030.100
Mouse
negative regulation of interleukin 10 secretionGO:200118020.100
regulation of mitotic cell cycleGO:00073461260.100
positive regulation of cytokine production involved in immune responseGO:0002720190.100
sphingolipid biosynthetic processGO:0030148260.100
regulation of rho gtpase activityGO:0032319580.100
positive regulation of lipopolysaccharide mediated signaling pathwayGO:003166650.099
nuclear importGO:0051170950.098
regulation of cd4 positive alpha beta t cell activationGO:2000514240.098
learning or memoryGO:00076111480.098
Fly
organic acid transportGO:00158491010.097
positive regulation of jun kinase activityGO:0043507300.097
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002823230.097
muscle cell differentiationGO:00426922610.097
regulation of synaptic growth at neuromuscular junctionGO:000858240.097
protein modification by small protein conjugationGO:00324461870.097
positive regulation of protein kinase b signalingGO:0051897320.097
morphogenesis of a branching structureGO:00017632030.096
Mouse
anion transportGO:00068201770.096
leukocyte activation involved in immune responseGO:00023661260.096
Mouse Rat
interleukin 13 secretionGO:007261120.095
blood coagulationGO:0007596760.095
Mouse
positive regulation of stress activated mapk cascadeGO:0032874480.094
somatic diversification of immunoglobulinsGO:0016445430.094
somatic diversification of immune receptors via germline recombination within a single locusGO:0002562510.093
myeloid cell activation involved in immune responseGO:0002275340.093
Mouse Rat
positive regulation of response to woundingGO:1903036660.093
regulation of erbb signaling pathwayGO:1901184160.093
phosphatidylinositol 3 kinase signalingGO:0014065360.093
regulation of tyrosine phosphorylation of stat proteinGO:0042509200.093
Mouse
regulation of jnk cascadeGO:0046328620.093
positive regulation of programmed cell deathGO:00430682180.092
Mouse
regulation of ras gtpase activityGO:0032318880.092
membrane invaginationGO:0010324170.092
microtubule based processGO:00070172360.092
negative regulation of b cell receptor signaling pathwayGO:005085940.091
positive regulation of sequence specific dna binding transcription factor activityGO:0051091680.091
regulation of actin filament lengthGO:0030832450.090
Fly
t cell mediated immunityGO:0002456500.090
regulation of cd4 positive alpha beta t cell differentiationGO:0043370210.089
regulation of interleukin 17 productionGO:003266080.089
regulation of cell adhesionGO:00301551540.089
Mouse
positive regulation of proteolysisGO:0045862850.088
regulation of establishment of protein localizationGO:00702011810.087
Mouse
immune response regulating signaling pathwayGO:00027641250.087
Mouse
regulation of leukocyte mediated immunityGO:00027031040.086
Mouse
regulation of intracellular transportGO:00323861590.086
Mouse
negative regulation of interleukin 5 productionGO:003271440.086
carbohydrate derivative catabolic processGO:19011362310.085
cellular response to molecule of bacterial originGO:0071219830.084
Mouse
membrane organizationGO:00610242450.084
regulation of jak stat cascadeGO:0046425340.084
Mouse
positive regulation of interferon gamma productionGO:0032729390.084
regulation of rho protein signal transductionGO:0035023710.083
skeletal muscle organ developmentGO:00605381630.083
neuronal action potentialGO:0019228540.083
purine nucleotide catabolic processGO:00061952110.082
positive regulation of chemotaxisGO:0050921380.081
regulation of production of molecular mediator of immune responseGO:0002700650.081
negative regulation of odontogenesis of dentin containing toothGO:004248910.080
camera type eye developmentGO:00430102660.080
axon ensheathmentGO:0008366760.080
glucose transportGO:0015758560.080
Mouse
t cell activationGO:00421102890.079
Mouse
antibacterial humoral responseGO:001973180.079
platelet activationGO:0030168400.079
Mouse
natural killer cell activationGO:0030101440.078
cellular response to starvationGO:0009267570.078
early endosome to late endosome transportGO:004502220.077
purinergic nucleotide receptor signaling pathwayGO:003559030.077
regulation of purine nucleotide metabolic processGO:19005421690.077
hypomethylation of cpg islandGO:004402910.077
neutrophil migrationGO:1990266370.077
innate immune responseGO:00450871570.076
Mouse
multicellular organism growthGO:00352641610.076
activation of jun kinase activityGO:0007257150.076
response to starvationGO:0042594650.076
negative regulation of interleukin 5 secretionGO:200066310.075
interleukin 6 productionGO:0032635580.075
synaptic transmissionGO:00072683290.075
intrinsic apoptotic signaling pathwayGO:00971931320.075
positive regulation of dendritic cell chemotaxisGO:200051010.075
positive regulation of lymphocyte mediated immunityGO:0002708620.075
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.074
lymphocyte migrationGO:0072676260.074
tissue remodelingGO:00487711020.073
Mouse
insulin receptor signaling pathwayGO:0008286490.073
regulation of epithelial cell proliferationGO:00506781410.073
cellular response to growth factor stimulusGO:00713631970.073
Mouse
inflammatory response to antigenic stimulusGO:0002437300.072
cell killingGO:0001906670.071
cd4 positive alpha beta t cell cytokine productionGO:003574340.071
regulation of hormone levelsGO:00108172110.070
Rat
positive regulation of nucleotide metabolic processGO:00459811140.070
negative regulation of kinase activityGO:0033673810.070
Mouse
regulation of cell morphogenesis involved in differentiationGO:00107691510.070
organonitrogen compound biosynthetic processGO:19015661920.069
inflammatory responseGO:00069542440.069
Mouse Rat
mitotic cell cycle processGO:19030471590.069
thymic t cell selectionGO:0045061220.068
regulation of protein targetingGO:1903533610.068
response to organic cyclic compoundGO:00140701980.068
cation transmembrane transportGO:00986552660.068
positive regulation of gtpase activityGO:0043547850.067
response to acid chemicalGO:00011011110.067
Mouse
organonitrogen compound catabolic processGO:19015652640.066
regulation of cellular component biogenesisGO:00440871810.066
Mouse Fly

Btk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
primary immunodeficiency diseaseDOID:61200.897
Human
immune system diseaseDOID:291400.897
Human
disease of anatomical entityDOID:700.897
Human
b cell deficiencyDOID:211500.897
Human
blood protein diseaseDOID:62000.621
Human
hematopoietic system diseaseDOID:7400.621
Human
agammaglobulinemiaDOID:258300.492
Human
common variable immunodeficiencyDOID:1217700.120
blood platelet diseaseDOID:221800.077
hemorrhagic diseaseDOID:221300.077
blood coagulation diseaseDOID:124700.077