IMP: Integrative Multi-species Prediction

Mus musculus

25 known processes

Insl3

insulin-like 3

(Aliases: Rlnl,Rlf)

Entrez: 16336
Ensembl: ENSMUSG00000079019
UniProtKB: Q5RL10

Process Predictions
Disease Predictions

Insl3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
male gamete generation	GO:0048232	285	0.166
chromatin modification	GO:0016568	187	0.115
cell adhesion	GO:0007155	329	0.109
lipid transport	GO:0006869	98	0.101
spermatid development	GO:0007286	108	0.091
chromatin organization	GO:0006325	206	0.091
response to organic cyclic compound	GO:0014070	198	0.077
multicellular organismal homeostasis	GO:0048871	164	0.076
germ cell development	GO:0007281	185	0.074	Rat
fertilization	GO:0009566	127	0.061
organic acid transport	GO:0015849	101	0.059
regulation of hormone levels	GO:0010817	211	0.059
spermatid differentiation	GO:0048515	115	0.057
transmembrane transport	GO:0055085	412	0.057
negative regulation of secretion	GO:0051048	61	0.054
protein maturation	GO:0051604	176	0.054
urogenital system development	GO:0001655	261	0.049
regulation of transferase activity	GO:0051338	263	0.049
defense response to other organism	GO:0098542	197	0.049
regulation of secretion	GO:0051046	274	0.048
spermatogenesis	GO:0007283	284	0.048
purine containing compound metabolic process	GO:0072521	311	0.048	Rat
regulation of cellular amine metabolic process	GO:0033238	20	0.048
cellular response to lipid	GO:0071396	145	0.047
regulation of secretion by cell	GO:1903530	249	0.046
ovarian follicle development	GO:0001541	40	0.045
cellular carbohydrate metabolic process	GO:0044262	119	0.043
apoptotic signaling pathway	GO:0097190	306	0.043
protein processing	GO:0016485	163	0.042
dna metabolic process	GO:0006259	303	0.042
blood circulation	GO:0008015	195	0.042
macromolecule catabolic process	GO:0009057	281	0.041
cellular ketone metabolic process	GO:0042180	84	0.040
regulation of cellular amino acid metabolic process	GO:0006521	5	0.040
organic cyclic compound catabolic process	GO:1901361	295	0.038
aromatic compound catabolic process	GO:0019439	286	0.038
regulation of kinase activity	GO:0043549	249	0.038
kidney development	GO:0001822	213	0.037
development of primary sexual characteristics	GO:0045137	143	0.037
regulation of lipid transport	GO:0032368	36	0.037
regulation of leukocyte differentiation	GO:1902105	159	0.037
female sex differentiation	GO:0046660	84	0.037
regulation of apoptotic signaling pathway	GO:2001233	197	0.035
regionalization	GO:0003002	337	0.035
cellular lipid metabolic process	GO:0044255	323	0.035
cellular response to growth factor stimulus	GO:0071363	197	0.034
negative regulation of cell proliferation	GO:0008285	296	0.034	Rat
lipid localization	GO:0010876	126	0.034
meiotic cell cycle process	GO:1903046	77	0.034
development of primary female sexual characteristics	GO:0046545	73	0.034
carbohydrate metabolic process	GO:0005975	230	0.033
endocrine process	GO:0050886	39	0.033
hormone secretion	GO:0046879	128	0.032
female gamete generation	GO:0007292	74	0.032	Rat
skeletal system development	GO:0001501	356	0.031
renal system development	GO:0072001	225	0.031
nucleotide metabolic process	GO:0009117	332	0.031	Rat
nitrogen compound transport	GO:0071705	271	0.031
synaptic transmission	GO:0007268	329	0.030
camera type eye development	GO:0043010	266	0.030
amide transport	GO:0042886	138	0.028
negative regulation of immune system process	GO:0002683	209	0.028
innate immune response	GO:0045087	157	0.028
cellular amine metabolic process	GO:0044106	44	0.027
nucleobase containing small molecule metabolic process	GO:0055086	352	0.027	Rat
anatomical structure homeostasis	GO:0060249	145	0.027
neuronal action potential	GO:0019228	54	0.027
extracellular matrix organization	GO:0030198	147	0.027
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.027
muscle cell differentiation	GO:0042692	261	0.027
steroid metabolic process	GO:0008202	119	0.027
single fertilization	GO:0007338	82	0.026
histone modification	GO:0016570	159	0.026
glycoprotein metabolic process	GO:0009100	116	0.026
regulation of hormone secretion	GO:0046883	88	0.026
cellular homeostasis	GO:0019725	240	0.026
positive regulation of transferase activity	GO:0051347	167	0.026
meiotic nuclear division	GO:0007126	115	0.025
gonad development	GO:0008406	141	0.025
leukocyte mediated immunity	GO:0002443	174	0.025
regulation of carbohydrate metabolic process	GO:0006109	75	0.025
small gtpase mediated signal transduction	GO:0007264	97	0.025
regulation of reproductive process	GO:2000241	66	0.025
cellular nitrogen compound catabolic process	GO:0044270	280	0.025
cell junction organization	GO:0034330	77	0.025
branching morphogenesis of an epithelial tube	GO:0048754	159	0.025
membrane organization	GO:0061024	245	0.025
exocytosis	GO:0006887	121	0.025
regulation of cell cycle	GO:0051726	281	0.024
peptide secretion	GO:0002790	114	0.024
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.024
carbohydrate derivative catabolic process	GO:1901136	231	0.024
blood vessel morphogenesis	GO:0048514	285	0.024
positive regulation of cellular amine metabolic process	GO:0033240	5	0.024
positive regulation of cell activation	GO:0050867	158	0.024
cellular amino acid metabolic process	GO:0006520	103	0.024
regulation of cellular ketone metabolic process	GO:0010565	66	0.024
cell substrate adhesion	GO:0031589	130	0.023
negative regulation of protein metabolic process	GO:0051248	282	0.023
regulation of neuron differentiation	GO:0045664	281	0.023
meiotic cell cycle	GO:0051321	122	0.022
extrinsic apoptotic signaling pathway	GO:0097191	126	0.022
regulation of protein serine threonine kinase activity	GO:0071900	157	0.022
heart morphogenesis	GO:0003007	178	0.022
regulation of multi organism process	GO:0043900	111	0.022
female gonad development	GO:0008585	71	0.022
microtubule based process	GO:0007017	236	0.021
cellular response to hormone stimulus	GO:0032870	150	0.021
ribose phosphate metabolic process	GO:0019693	291	0.021	Rat
cellular chemical homeostasis	GO:0055082	215	0.021
protein oligomerization	GO:0051259	67	0.021
regulation of lymphocyte activation	GO:0051249	240	0.021
peptide hormone secretion	GO:0030072	109	0.021
glycosyl compound metabolic process	GO:1901657	246	0.021
monocarboxylic acid metabolic process	GO:0032787	191	0.021
regulation of systemic arterial blood pressure	GO:0003073	61	0.020
regulation of protein transport	GO:0051223	163	0.020
negative regulation of cellular component organization	GO:0051129	194	0.020
negative regulation of cell development	GO:0010721	169	0.020
fatty acid metabolic process	GO:0006631	121	0.020
positive regulation of lymphocyte activation	GO:0051251	140	0.019
nucleoside phosphate metabolic process	GO:0006753	338	0.019	Rat
regulation of cell adhesion	GO:0030155	154	0.019
transcription from rna polymerase iii promoter	GO:0006383	3	0.019
protein modification by small protein conjugation or removal	GO:0070647	207	0.019
striated muscle tissue development	GO:0014706	293	0.019
cell matrix adhesion	GO:0007160	68	0.019
heterocycle catabolic process	GO:0046700	280	0.018
placenta development	GO:0001890	140	0.018
ion transmembrane transport	GO:0034220	361	0.018
regulation of blood pressure	GO:0008217	93	0.018
response to drug	GO:0042493	75	0.018
regulation of cytokine production	GO:0001817	266	0.018
ribonucleoside metabolic process	GO:0009119	245	0.018
morphogenesis of a branching structure	GO:0001763	203	0.018
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.018
sensory perception	GO:0007600	245	0.018
regulation of cell activation	GO:0050865	289	0.018
cell maturation	GO:0048469	127	0.018	Rat
adaptive immune response	GO:0002250	155	0.018
alcohol metabolic process	GO:0006066	116	0.018
negative regulation of cellular protein metabolic process	GO:0032269	247	0.018
mitochondrion organization	GO:0007005	134	0.018
positive regulation of nf kappab transcription factor activity	GO:0051092	30	0.018
zymogen activation	GO:0031638	41	0.017
cellular response to dna damage stimulus	GO:0006974	207	0.017
nucleotide catabolic process	GO:0009166	217	0.017
oocyte construction	GO:0007308	2	0.017
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.017
positive regulation of protein modification process	GO:0031401	299	0.017
regulation of purine nucleotide metabolic process	GO:1900542	169	0.017	Rat
lymphocyte mediated immunity	GO:0002449	139	0.017
protein localization to organelle	GO:0033365	185	0.017
response to organonitrogen compound	GO:0010243	246	0.017
posttranscriptional regulation of gene expression	GO:0010608	155	0.017
organophosphate catabolic process	GO:0046434	232	0.017
ear development	GO:0043583	200	0.017
developmental growth involved in morphogenesis	GO:0060560	138	0.016
regulation of map kinase activity	GO:0043405	120	0.016
epithelial cell development	GO:0002064	159	0.016
appendage development	GO:0048736	166	0.016
ossification	GO:0001503	216	0.016
inflammatory response	GO:0006954	244	0.016
single organism cell adhesion	GO:0098602	156	0.016
extracellular structure organization	GO:0043062	148	0.016
cellularization	GO:0007349	1	0.016
response to extracellular stimulus	GO:0009991	127	0.016
response to acid chemical	GO:0001101	111	0.016
nephron epithelium development	GO:0072009	92	0.016
regulation of homeostatic process	GO:0032844	182	0.016
somatic sex determination	GO:0018993	2	0.016
small molecule biosynthetic process	GO:0044283	132	0.016
male gonad development	GO:0008584	88	0.016
oogenesis	GO:0048477	56	0.016	Rat
positive regulation of t cell differentiation	GO:0045582	52	0.016
covalent chromatin modification	GO:0016569	163	0.016
regulation of chromosome organization	GO:0033044	83	0.016
muscle tissue development	GO:0060537	308	0.016
regulation of blood vessel size	GO:0050880	56	0.015
mapk cascade	GO:0000165	281	0.015
anion transport	GO:0006820	177	0.015
reactive oxygen species metabolic process	GO:0072593	84	0.015
organic anion transport	GO:0015711	137	0.015
regulation of protein maturation	GO:1903317	96	0.015
regulation of organelle organization	GO:0033043	289	0.015
response to molecule of bacterial origin	GO:0002237	143	0.015
regulation of vesicle mediated transport	GO:0060627	139	0.015
action potential	GO:0001508	78	0.015
response to lipopolysaccharide	GO:0032496	128	0.015
rhythmic process	GO:0048511	174	0.015
intracellular mrna localization	GO:0008298	4	0.015
response to radiation	GO:0009314	165	0.015
forebrain development	GO:0030900	302	0.015
response to peptide hormone	GO:0043434	127	0.015
negative regulation of cellular catabolic process	GO:0031330	47	0.015
compound eye development	GO:0048749	1	0.015
embryonic organ morphogenesis	GO:0048562	276	0.015
positive regulation of lymphocyte differentiation	GO:0045621	61	0.015
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.015
nucleoside triphosphate catabolic process	GO:0009143	205	0.015
response to monosaccharide	GO:0034284	67	0.015
keratinocyte migration	GO:0051546	3	0.014
positive regulation of kinase activity	GO:0033674	155	0.014
ribonucleotide catabolic process	GO:0009261	208	0.014
cell junction assembly	GO:0034329	52	0.014
epidermis development	GO:0008544	187	0.014
lymphocyte differentiation	GO:0030098	242	0.014
hematopoietic progenitor cell differentiation	GO:0002244	143	0.014
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.014
oocyte axis specification	GO:0007309	2	0.014
blood coagulation	GO:0007596	76	0.014
connective tissue development	GO:0061448	179	0.014
tissue homeostasis	GO:0001894	115	0.014
stem cell development	GO:0048864	219	0.014
hemostasis	GO:0007599	78	0.014
organonitrogen compound catabolic process	GO:1901565	264	0.014
cellular response to cadmium ion	GO:0071276	3	0.014
cation transmembrane transport	GO:0098655	266	0.014
positive regulation of growth	GO:0045927	104	0.014
regulation of t cell activation	GO:0050863	170	0.014
positive regulation of protein kinase activity	GO:0045860	144	0.014
organic acid biosynthetic process	GO:0016053	86	0.014
defense response to bacterium	GO:0042742	119	0.014
epithelial tube morphogenesis	GO:0060562	303	0.014
kidney epithelium development	GO:0072073	121	0.014
respiratory tube development	GO:0030323	167	0.014
regulation of ion transport	GO:0043269	215	0.014
cytokine mediated signaling pathway	GO:0019221	115	0.014
positive regulation of intracellular transport	GO:0032388	70	0.014
epithelium migration	GO:0090132	63	0.013
negative regulation of reproductive process	GO:2000242	31	0.013
cellular response to extracellular stimulus	GO:0031668	81	0.013
male sex differentiation	GO:0046661	109	0.013
negative regulation of protein maturation	GO:1903318	79	0.013
reactive oxygen species biosynthetic process	GO:1903409	8	0.013
regulation of cell cycle process	GO:0010564	160	0.013
sensory organ morphogenesis	GO:0090596	242	0.013
cellular response to biotic stimulus	GO:0071216	92	0.013
alpha amino acid metabolic process	GO:1901605	59	0.013
regulation of leukocyte apoptotic process	GO:2000106	56	0.013
nephron development	GO:0072006	109	0.013
purine nucleoside metabolic process	GO:0042278	241	0.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.013
olfactory learning	GO:0008355	2	0.013
purine nucleotide metabolic process	GO:0006163	302	0.013	Rat
dna conformation change	GO:0071103	37	0.013
macromolecule methylation	GO:0043414	120	0.013
renal tubule morphogenesis	GO:0061333	72	0.013
multicellular organism growth	GO:0035264	161	0.013
protein localization to membrane	GO:0072657	108	0.013
cation transport	GO:0006812	399	0.013
ribonucleotide metabolic process	GO:0009259	291	0.013	Rat
negative regulation of protein modification process	GO:0031400	163	0.013
regulation of protein kinase activity	GO:0045859	232	0.013
positive regulation of t cell activation	GO:0050870	101	0.013
positive regulation of innate immune response	GO:0045089	80	0.013
endocrine hormone secretion	GO:0060986	15	0.013
regulation of establishment of protein localization	GO:0070201	181	0.013
myeloid cell homeostasis	GO:0002262	114	0.013
negative regulation of secretion by cell	GO:1903531	54	0.013
mesonephric tubule development	GO:0072164	94	0.013
cellular response to lipopolysaccharide	GO:0071222	77	0.013
regulation of neural precursor cell proliferation	GO:2000177	70	0.012
negative regulation of phosphorus metabolic process	GO:0010563	184	0.012
viral process	GO:0016032	41	0.012
binding of sperm to zona pellucida	GO:0007339	34	0.012
regulation of endocytosis	GO:0030100	69	0.012
positive regulation of leukocyte differentiation	GO:1902107	86	0.012
regulation of protein processing	GO:0070613	96	0.012
maternal determination of anterior posterior axis embryo	GO:0008358	2	0.012
negative regulation of cell cycle	GO:0045786	123	0.012
neurotransmitter transport	GO:0006836	76	0.012
methylation	GO:0032259	134	0.012
organic hydroxy compound biosynthetic process	GO:1901617	77	0.012
regulation of neuron projection development	GO:0010975	169	0.012
adult behavior	GO:0030534	135	0.012
regulation of response to wounding	GO:1903034	189	0.012
skeletal muscle organ development	GO:0060538	163	0.012
cellular response to organic cyclic compound	GO:0071407	87	0.012
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.012
synapse organization	GO:0050808	125	0.012
regulation of endocrine process	GO:0044060	13	0.012
protein alkylation	GO:0008213	81	0.012
peptide transport	GO:0015833	133	0.012
nucleoside catabolic process	GO:0009164	206	0.012
regulation of stem cell proliferation	GO:0072091	78	0.012
ribonucleoside catabolic process	GO:0042454	206	0.012
regulation of intracellular transport	GO:0032386	159	0.012
protein catabolic process	GO:0030163	221	0.012
positive regulation of leukocyte mediated immunity	GO:0002705	70	0.012
cellular glucose homeostasis	GO:0001678	52	0.012
male anatomical structure morphogenesis	GO:0090598	4	0.012
development of primary male sexual characteristics	GO:0046546	88	0.011
lymphocyte proliferation	GO:0046651	164	0.011
purine ribonucleotide catabolic process	GO:0009154	208	0.011
multicellular organismal signaling	GO:0035637	91	0.011
organelle fission	GO:0048285	170	0.011
visual behavior	GO:0007632	45	0.011
ureteric bud morphogenesis	GO:0060675	62	0.011
carbohydrate homeostasis	GO:0033500	128	0.011
regulation of cell motility	GO:2000145	236	0.011
positive regulation of map kinase activity	GO:0043406	84	0.011
regulation of system process	GO:0044057	200	0.011
reactive nitrogen species metabolic process	GO:2001057	0	0.011
regulation of hydrolase activity	GO:0051336	246	0.011
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.011
purine ribonucleoside catabolic process	GO:0046130	205	0.011
response to hypoxia	GO:0001666	58	0.011
negative regulation of intracellular signal transduction	GO:1902532	167	0.011
positive regulation of programmed cell death	GO:0043068	218	0.011
defense response to gram negative bacterium	GO:0050829	28	0.011
purine nucleotide catabolic process	GO:0006195	211	0.011
positive regulation of angiogenesis	GO:0045766	46	0.011
cellular response to steroid hormone stimulus	GO:0071383	33	0.011
histone lysine methylation	GO:0034968	50	0.011
immune response regulating signaling pathway	GO:0002764	125	0.011
purine ribonucleotide metabolic process	GO:0009150	290	0.011	Rat
regulation of cellular protein catabolic process	GO:1903362	61	0.011
negative regulation of mapk cascade	GO:0043409	65	0.011
dna packaging	GO:0006323	30	0.011
response to oxygen levels	GO:0070482	62	0.011
locomotory behavior	GO:0007626	195	0.011
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.011
macromolecule deacylation	GO:0098732	37	0.011
response to light stimulus	GO:0009416	135	0.011
ras protein signal transduction	GO:0007265	77	0.011
regulation of protein localization	GO:0032880	231	0.011
regulation of lymphocyte differentiation	GO:0045619	107	0.011
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.011
regulation of protein catabolic process	GO:0042176	108	0.011
carboxylic acid biosynthetic process	GO:0046394	86	0.010
sodium ion transport	GO:0006814	73	0.010
single organismal cell cell adhesion	GO:0016337	131	0.010
carboxylic acid transport	GO:0046942	100	0.010
nucleoside phosphate biosynthetic process	GO:1901293	79	0.010	Rat
purine ribonucleoside metabolic process	GO:0046128	241	0.010
atp metabolic process	GO:0046034	75	0.010
cellular lipid catabolic process	GO:0044242	52	0.010
translation	GO:0006412	93	0.010
glycosyl compound catabolic process	GO:1901658	206	0.010
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.010
peptidyl tyrosine phosphorylation	GO:0018108	143	0.010
cellular response to molecule of bacterial origin	GO:0071219	83	0.010
nucleic acid phosphodiester bond hydrolysis	GO:0090305	49	0.010
hepaticobiliary system development	GO:0061008	67	0.010
intrinsic apoptotic signaling pathway	GO:0097193	132	0.010
nucleoside phosphate catabolic process	GO:1901292	222	0.010
regulation of mapk cascade	GO:0043408	248	0.010
cellular macromolecule catabolic process	GO:0044265	206	0.010
regulation of membrane potential	GO:0042391	192	0.010
viral life cycle	GO:0019058	36	0.010
negative regulation of t cell activation	GO:0050868	65	0.010
spermatogenesis exchange of chromosomal proteins	GO:0035093	4	0.010

Insl3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.046
disease of anatomical entity	DOID:7	0.046
disease of metabolism	DOID:0014667	0.031
central nervous system disease	DOID:331	0.028
musculoskeletal system disease	DOID:17	0.022
cancer	DOID:162	0.022
disease of cellular proliferation	DOID:14566	0.022
neurodegenerative disease	DOID:1289	0.021
motor neuron disease	DOID:231	0.016
physical disorder	DOID:0080015	0.015
organ system cancer	DOID:0050686	0.012

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