IMP: Integrative Multi-species Prediction

Mus musculus

23 known processes

Adam24

a disintegrin and metallopeptidase domain 24 (testase 1)

(Aliases: Dtgn5)

Ensembl: ENSMUSG00000046723
Entrez: 13526
UniProtKB: Q8CDV3
UniProtKB: Q9R160

Process Predictions
Disease Predictions

Adam24 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cellular homeostasis	GO:0019725	240	0.091
cation transport	GO:0006812	399	0.079
spermatogenesis	GO:0007283	284	0.073
regulation of membrane potential	GO:0042391	192	0.063	Mouse
fertilization	GO:0009566	127	0.057
male gamete generation	GO:0048232	285	0.052
cellular chemical homeostasis	GO:0055082	215	0.051
spermatid differentiation	GO:0048515	115	0.049
regulation of cellular ketone metabolic process	GO:0010565	66	0.049
leukocyte differentiation	GO:0002521	342	0.049	Mouse
positive regulation of thymocyte migration	GO:2000412	2	0.046	Mouse
cellular ketone metabolic process	GO:0042180	84	0.043
regulation of hormone levels	GO:0010817	211	0.037
ion transmembrane transport	GO:0034220	361	0.034
regulation of cellular amino acid metabolic process	GO:0006521	5	0.033
protein catabolic process	GO:0030163	221	0.033	Mouse
cellular amine metabolic process	GO:0044106	44	0.032
cation transmembrane transport	GO:0098655	266	0.031
small gtpase mediated signal transduction	GO:0007264	97	0.031
regulation of t cell activation	GO:0050863	170	0.031	Mouse
glucose homeostasis	GO:0042593	128	0.031
muscle tissue development	GO:0060537	308	0.031
regulation of lymphocyte activation	GO:0051249	240	0.031	Mouse
transmembrane transport	GO:0055085	412	0.029
neuronal action potential	GO:0019228	54	0.029	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.028
germ cell development	GO:0007281	185	0.028
cellular ion homeostasis	GO:0006873	165	0.027
hematopoietic progenitor cell differentiation	GO:0002244	143	0.027
single fertilization	GO:0007338	82	0.026
regulation of cell cycle	GO:0051726	281	0.026
regulation of transferase activity	GO:0051338	263	0.026	Mouse
regulation of response to wounding	GO:1903034	189	0.026	Mouse
response to radiation	GO:0009314	165	0.026	Mouse
striated muscle tissue development	GO:0014706	293	0.025
action potential	GO:0001508	78	0.025	Mouse
t cell activation	GO:0042110	289	0.025	Mouse
mitochondrion organization	GO:0007005	134	0.025
leukocyte mediated immunity	GO:0002443	174	0.024
muscle system process	GO:0003012	141	0.024
inflammatory response	GO:0006954	244	0.024	Mouse
carbohydrate homeostasis	GO:0033500	128	0.024
cellular response to hexose stimulus	GO:0071331	47	0.024
nitrogen compound transport	GO:0071705	271	0.024
inorganic cation transmembrane transport	GO:0098662	207	0.023
positive regulation of protein modification process	GO:0031401	299	0.023	Mouse
epithelial cell proliferation	GO:0050673	174	0.023
physiological cardiac muscle hypertrophy	GO:0003301	3	0.022
regulation of cellular amine metabolic process	GO:0033238	20	0.022
peptidyl amino acid modification	GO:0018193	336	0.022
exocytosis	GO:0006887	121	0.022
protein maturation	GO:0051604	176	0.022
striated muscle cell development	GO:0055002	125	0.021
aromatic compound catabolic process	GO:0019439	286	0.021
cellular response to carbohydrate stimulus	GO:0071322	50	0.020
spermatid development	GO:0007286	108	0.020
activation of mapk activity involved in innate immune response	GO:0035419	2	0.020	Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.020	Mouse
regulation of protein kinase activity	GO:0045859	232	0.020	Mouse
carbohydrate metabolic process	GO:0005975	230	0.020
heterocycle catabolic process	GO:0046700	280	0.020
regulation of epithelial cell proliferation	GO:0050678	141	0.020
carbohydrate derivative catabolic process	GO:1901136	231	0.020
rho protein signal transduction	GO:0007266	32	0.020
anion transport	GO:0006820	177	0.020
response to organonitrogen compound	GO:0010243	246	0.020
regulation of lymphocyte differentiation	GO:0045619	107	0.020	Mouse
blood vessel morphogenesis	GO:0048514	285	0.019	Mouse
eosinophil migration	GO:0072677	3	0.019	Mouse
cellular nitrogen compound catabolic process	GO:0044270	280	0.019
cation homeostasis	GO:0055080	212	0.019
cell growth involved in cardiac muscle cell development	GO:0061049	3	0.019
mapk cascade	GO:0000165	281	0.018	Mouse
positive regulation of kinase activity	GO:0033674	155	0.018	Mouse
regulation of eosinophil migration	GO:2000416	2	0.018	Mouse
apoptotic signaling pathway	GO:0097190	306	0.018
regulation of binding	GO:0051098	111	0.018
macromolecule catabolic process	GO:0009057	281	0.018	Mouse
anatomical structure homeostasis	GO:0060249	145	0.017	Mouse
cytoplasmic transport	GO:0016482	234	0.017
regulation of cell growth involved in cardiac muscle cell development	GO:0061050	3	0.017
phospholipid metabolic process	GO:0006644	87	0.017
negative regulation of molecular function	GO:0044092	258	0.017
regulation of hydrolase activity	GO:0051336	246	0.017
regulation of cellular component biogenesis	GO:0044087	181	0.017
regulation of cellular catabolic process	GO:0031329	242	0.017	Mouse
regulation of intracellular transport	GO:0032386	159	0.017
regulation of cell activation	GO:0050865	289	0.017	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.017
muscle cell development	GO:0055001	133	0.017
lymphocyte mediated immunity	GO:0002449	139	0.017
kidney development	GO:0001822	213	0.017
glycoprotein metabolic process	GO:0009100	116	0.016
cellular response to peptide hormone stimulus	GO:0071375	92	0.016
regulation of neuron differentiation	GO:0045664	281	0.016
negative regulation of phosphorylation	GO:0042326	166	0.016
carbohydrate derivative biosynthetic process	GO:1901137	183	0.016
regulation of kinase activity	GO:0043549	249	0.016	Mouse
divalent inorganic cation homeostasis	GO:0072507	138	0.016
connective tissue development	GO:0061448	179	0.016
cellular calcium ion homeostasis	GO:0006874	119	0.016
sensory perception	GO:0007600	245	0.016
embryonic organ morphogenesis	GO:0048562	276	0.016
positive regulation of protein phosphorylation	GO:0001934	242	0.016	Mouse
circadian rhythm	GO:0007623	114	0.016
cellular response to lipid	GO:0071396	145	0.016
posttranscriptional regulation of gene expression	GO:0010608	155	0.016
organic cyclic compound catabolic process	GO:1901361	295	0.016
protein processing	GO:0016485	163	0.015
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.015	Mouse
multi multicellular organism process	GO:0044706	109	0.015
regulation of secretion by cell	GO:1903530	249	0.015
metal ion homeostasis	GO:0055065	189	0.015
regulation of cell motility	GO:2000145	236	0.015	Mouse
positive regulation of transferase activity	GO:0051347	167	0.015	Mouse
negative regulation of cell growth involved in cardiac muscle cell development	GO:0061052	2	0.015
response to nutrient levels	GO:0031667	109	0.015
regulation of proteolysis	GO:0030162	164	0.015	Mouse
lymphocyte differentiation	GO:0030098	242	0.015	Mouse
response to peptide	GO:1901652	136	0.015
olfactory learning	GO:0008355	2	0.015
cellular lipid metabolic process	GO:0044255	323	0.015
renal system development	GO:0072001	225	0.015
response to light stimulus	GO:0009416	135	0.015	Mouse
organelle fission	GO:0048285	170	0.015
regulation of circadian sleep wake cycle	GO:0042749	3	0.014
meiotic nuclear division	GO:0007126	115	0.014
myelination	GO:0042552	74	0.014	Mouse
cellular response to testosterone stimulus	GO:0071394	1	0.014
oxidation reduction process	GO:0055114	342	0.014
positive regulation of lymphocyte activation	GO:0051251	140	0.014	Mouse
negative regulation of cellular protein metabolic process	GO:0032269	247	0.014
urogenital system development	GO:0001655	261	0.014
cellular response to organonitrogen compound	GO:0071417	145	0.014
cellular response to peptide	GO:1901653	92	0.014
cellular response to cytokine stimulus	GO:0071345	189	0.014
regulation of secretion	GO:0051046	274	0.014
fat cell differentiation	GO:0045444	160	0.014
response to extracellular stimulus	GO:0009991	127	0.014
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.014
muscle cell differentiation	GO:0042692	261	0.014
regulation of neuron death	GO:1901214	134	0.014	Mouse
insulin receptor signaling pathway	GO:0008286	49	0.014
organonitrogen compound catabolic process	GO:1901565	264	0.014
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.014
cognition	GO:0050890	149	0.013	Mouse
protein modification by small protein conjugation	GO:0032446	187	0.013
myotube differentiation	GO:0014902	105	0.013
nucleocytoplasmic transport	GO:0006913	139	0.013
nuclear division	GO:0000280	158	0.013
cellular glucose homeostasis	GO:0001678	52	0.013
sequestering of metal ion	GO:0051238	19	0.013
physiological muscle hypertrophy	GO:0003298	3	0.013
defense response to bacterium	GO:0042742	119	0.013
leukocyte proliferation	GO:0070661	172	0.013
ras protein signal transduction	GO:0007265	77	0.013
endocytosis	GO:0006897	168	0.013
immune effector process	GO:0002252	321	0.013
methylation	GO:0032259	134	0.013
regulation of protein catabolic process	GO:0042176	108	0.013	Mouse
negative regulation of protein phosphorylation	GO:0001933	126	0.013
purine nucleotide metabolic process	GO:0006163	302	0.013
nucleoside phosphate catabolic process	GO:1901292	222	0.013
extracellular structure organization	GO:0043062	148	0.013
sperm egg recognition	GO:0035036	37	0.013	Mouse
response to monosaccharide	GO:0034284	67	0.013
cellular macromolecule catabolic process	GO:0044265	206	0.013
actin cytoskeleton organization	GO:0030036	220	0.013
insulin secretion	GO:0030073	89	0.013
camera type eye development	GO:0043010	266	0.013
negative regulation of protein metabolic process	GO:0051248	282	0.013
positive regulation of eosinophil migration	GO:2000418	2	0.013	Mouse
dna metabolic process	GO:0006259	303	0.013
response to peptide hormone	GO:0043434	127	0.012
regulation of organelle organization	GO:0033043	289	0.012
glycoprotein biosynthetic process	GO:0009101	89	0.012
skeletal system morphogenesis	GO:0048705	203	0.012
tube formation	GO:0035148	140	0.012
gland development	GO:0048732	330	0.012
regulation of protein serine threonine kinase activity	GO:0071900	157	0.012	Mouse
regulation of protein processing	GO:0070613	96	0.012
macromolecule methylation	GO:0043414	120	0.012
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.012	Mouse
cellular response to glucose stimulus	GO:0071333	45	0.012
sequestering of calcium ion	GO:0051208	18	0.012
negative regulation of blood vessel endothelial cell migration	GO:0043537	3	0.012
cellular response to organic cyclic compound	GO:0071407	87	0.012
nucleobase containing small molecule metabolic process	GO:0055086	352	0.012
positive regulation of map kinase activity	GO:0043406	84	0.012	Mouse
hormone secretion	GO:0046879	128	0.012
peptide secretion	GO:0002790	114	0.012
response to testosterone	GO:0033574	3	0.012
purine ribonucleoside metabolic process	GO:0046128	241	0.012
multicellular organism growth	GO:0035264	161	0.011
rhythmic process	GO:0048511	174	0.011
protein modification by small protein conjugation or removal	GO:0070647	207	0.011
regulation of multi organism process	GO:0043900	111	0.011
chemotaxis	GO:0006935	247	0.011	Mouse
regulation of cell projection organization	GO:0031344	206	0.011
respiratory system development	GO:0060541	190	0.011
nucleotide catabolic process	GO:0009166	217	0.011
protein kinase b signaling	GO:0043491	74	0.011	Mouse
regulation of insulin secretion involved in cellular response to glucose stimulus	GO:0061178	31	0.011
divalent metal ion transport	GO:0070838	172	0.011
learning or memory	GO:0007611	148	0.011	Mouse
transition metal ion homeostasis	GO:0055076	54	0.011
negative regulation of cell development	GO:0010721	169	0.011
nucleoside triphosphate metabolic process	GO:0009141	230	0.011
stem cell development	GO:0048864	219	0.011	Mouse
regulation of establishment of protein localization	GO:0070201	181	0.011
cellular response to hormone stimulus	GO:0032870	150	0.011
compound eye development	GO:0048749	1	0.011
wnt signaling pathway	GO:0016055	188	0.011
protein ubiquitination	GO:0016567	171	0.011
blastocyst development	GO:0001824	80	0.011
maintenance of location	GO:0051235	89	0.011
regulation of t cell proliferation	GO:0042129	92	0.011
peptide transport	GO:0015833	133	0.011
regulation of striated muscle cell differentiation	GO:0051153	81	0.011
response to organic cyclic compound	GO:0014070	198	0.011	Mouse
negative regulation of response to wounding	GO:1903035	77	0.011
ribonucleotide catabolic process	GO:0009261	208	0.011
cellular metal ion homeostasis	GO:0006875	151	0.011
regulation of defense response	GO:0031347	233	0.011	Mouse
response to transforming growth factor beta	GO:0071559	88	0.011	Mouse
negative regulation of cellular component organization	GO:0051129	194	0.010
positive regulation of membrane protein ectodomain proteolysis	GO:0051044	3	0.010	Mouse
tissue homeostasis	GO:0001894	115	0.010	Mouse
single organism cell adhesion	GO:0098602	156	0.010	Mouse
regulation of muscle tissue development	GO:1901861	97	0.010
positive regulation of defense response	GO:0031349	124	0.010	Mouse
calcium ion homeostasis	GO:0055074	127	0.010
endomembrane system organization	GO:0010256	147	0.010
ribonucleoside metabolic process	GO:0009119	245	0.010
purine containing compound metabolic process	GO:0072521	311	0.010
amide transport	GO:0042886	138	0.010
b cell mediated immunity	GO:0019724	71	0.010
intracellular protein transport	GO:0006886	204	0.010
cellular carbohydrate metabolic process	GO:0044262	119	0.010
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.010
response to insulin	GO:0032868	100	0.010
cellular response to monosaccharide stimulus	GO:0071326	47	0.010
purine ribonucleotide catabolic process	GO:0009154	208	0.010
purine containing compound catabolic process	GO:0072523	213	0.010
ribose phosphate metabolic process	GO:0019693	291	0.010
negative regulation of endothelial cell migration	GO:0010596	4	0.010
organophosphate catabolic process	GO:0046434	232	0.010
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway	GO:1902176	4	0.010
organic hydroxy compound transport	GO:0015850	93	0.010
ribonucleotide metabolic process	GO:0009259	291	0.010
extracellular matrix organization	GO:0030198	147	0.010
epithelial cell development	GO:0002064	159	0.010

Adam24 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.033
disease of anatomical entity	DOID:7	0.033
disease of metabolism	DOID:0014667	0.016
disease of cellular proliferation	DOID:14566	0.012
cancer	DOID:162	0.012
sensory system disease	DOID:0050155	0.011

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