IMP: Integrative Multi-species Prediction

Mus musculus

98 known processes

Atf3

activating transcription factor 3

(Aliases: LRG-21)

Ensembl: ENSMUSG00000026628
Entrez: 11910
UniProtKB: Q4FJW1
UniProtKB: Q60765

Process Predictions
Disease Predictions

Atf3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of cyclin dependent protein serine threonine kinase activity involved in g2 m transition of mitotic cell cycle	GO:0031660	1	0.803	Fly
cytokine production	GO:0001816	319	0.714
response to molecule of bacterial origin	GO:0002237	143	0.628
regulation of cytokine production	GO:0001817	266	0.574
placenta blood vessel development	GO:0060674	31	0.514	Mouse
leukocyte differentiation	GO:0002521	342	0.511	Mouse
positive regulation of t helper 1 cell differentiation	GO:0045627	4	0.507
positive regulation of transforming growth factor beta2 production	GO:0032915	2	0.505
negative regulation of transcription from rna polymerase ii promoter in response to stress	GO:0097201	1	0.483
response to lipopolysaccharide	GO:0032496	128	0.470
regulation of transferase activity	GO:0051338	263	0.467	Fly
regulation of transcription from rna polymerase ii promoter in response to stress	GO:0043618	8	0.424
positive regulation of nuclear transcribed mrna poly a tail shortening	GO:0060213	4	0.424
negative regulation of cellular protein metabolic process	GO:0032269	247	0.421
positive regulation of fibroblast proliferation	GO:0048146	20	0.408	Mouse
positive regulation of apoptotic process	GO:0043065	217	0.398
placenta development	GO:0001890	140	0.396	Mouse
negative regulation of multi organism process	GO:0043901	68	0.381
conditioned taste aversion	GO:0001661	4	0.369
positive regulation of cell death	GO:0010942	224	0.358
mitochondrion organization	GO:0007005	134	0.346
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	16	0.345	Fly
interspecies interaction between organisms	GO:0044419	83	0.338
transforming growth factor beta2 production	GO:0032906	2	0.325
striated muscle tissue development	GO:0014706	293	0.324
skeletal muscle organ development	GO:0060538	163	0.319
positive regulation of mrna 3 end processing	GO:0031442	5	0.304
regulation of protein kinase activity	GO:0045859	232	0.296	Fly
response to metal ion	GO:0010038	47	0.276	Mouse
regulation of neuron apoptotic process	GO:0043523	122	0.275
t cell differentiation	GO:0030217	174	0.274
cell type specific apoptotic process	GO:0097285	268	0.273
positive regulation of neutrophil mediated killing of symbiont cell	GO:0070961	1	0.273
jnk cascade	GO:0007254	72	0.270
positive regulation of cytokine production	GO:0001819	174	0.266
ras protein signal transduction	GO:0007265	77	0.265
positive regulation of neuron apoptotic process	GO:0043525	25	0.259
immune effector process	GO:0002252	321	0.258
regulation of defense response	GO:0031347	233	0.253
regulation of antimicrobial humoral response	GO:0002759	3	0.253
response to radiation	GO:0009314	165	0.253
regulation of brown fat cell differentiation	GO:0090335	5	0.251
brain segmentation	GO:0035284	3	0.250
blood vessel morphogenesis	GO:0048514	285	0.248
response to endoplasmic reticulum stress	GO:0034976	53	0.241
negative regulation of protein metabolic process	GO:0051248	282	0.241
microglial cell activation	GO:0001774	3	0.241
stress activated protein kinase signaling cascade	GO:0031098	81	0.241
regulation of cell cycle	GO:0051726	281	0.238	Fly
positive regulation of programmed cell death	GO:0043068	218	0.234
negative regulation of response to wounding	GO:1903035	77	0.229
fat cell differentiation	GO:0045444	160	0.227	Mouse
nucleobase containing small molecule metabolic process	GO:0055086	352	0.223
negative regulation of phosphorylation	GO:0042326	166	0.221
regulation of cellular amino acid metabolic process	GO:0006521	5	0.220
regulation of kinase activity	GO:0043549	249	0.218	Fly
positive regulation of protein modification process	GO:0031401	299	0.212	Mouse
osteoclast differentiation	GO:0030316	62	0.203	Mouse
cellular response to gamma radiation	GO:0071480	4	0.202
response to organic cyclic compound	GO:0014070	198	0.201
regulation of neutrophil mediated killing of gram negative bacterium	GO:0070951	1	0.200
myeloid cell differentiation	GO:0030099	233	0.200	Mouse
cation transport	GO:0006812	399	0.199
regulation of leukocyte differentiation	GO:1902105	159	0.196	Mouse
cellular response to inorganic substance	GO:0071241	37	0.193	Mouse
cellular ketone metabolic process	GO:0042180	84	0.190
t cell differentiation in thymus	GO:0033077	77	0.185
covalent chromatin modification	GO:0016569	163	0.181	Mouse
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.180
regulation of nucleotide metabolic process	GO:0006140	169	0.175
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.172
positive regulation of leukocyte differentiation	GO:1902107	86	0.172	Mouse
regulation of multi organism process	GO:0043900	111	0.171
regulation of inflammatory response	GO:0050727	147	0.171
positive regulation of rhodopsin gene expression	GO:0045872	2	0.169
muscle tissue development	GO:0060537	308	0.169
wound healing	GO:0042060	157	0.167	Fly
chromatin organization	GO:0006325	206	0.165	Mouse
nucleoside phosphate metabolic process	GO:0006753	338	0.161
fibroblast proliferation	GO:0048144	35	0.160	Mouse
regulation of fibroblast proliferation	GO:0048145	34	0.159	Mouse
small gtpase mediated signal transduction	GO:0007264	97	0.158
negative regulation of protein modification process	GO:0031400	163	0.158
heterocycle catabolic process	GO:0046700	280	0.157
regulation of cellular catabolic process	GO:0031329	242	0.154
negative regulation of protein kinase activity by regulation of protein phosphorylation	GO:0044387	2	0.153
positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay	GO:1900153	5	0.153
neutrophil mediated killing of gram negative bacterium	GO:0070945	4	0.152
response to transforming growth factor beta	GO:0071559	88	0.152
positive regulation of myeloid leukocyte differentiation	GO:0002763	26	0.149	Mouse
purine ribonucleotide metabolic process	GO:0009150	290	0.149
regeneration	GO:0031099	38	0.148	Fly
myeloid leukocyte activation	GO:0002274	83	0.148
purine nucleotide metabolic process	GO:0006163	302	0.147
positive regulation of ras gtpase activity	GO:0032320	65	0.147
glycosyl compound metabolic process	GO:1901657	246	0.145
interaction with symbiont	GO:0051702	14	0.144
cellular response to biotic stimulus	GO:0071216	92	0.143
negative regulation of molecular function	GO:0044092	258	0.143
negative regulation of viral transcription	GO:0032897	3	0.142
negative regulation of phosphorus metabolic process	GO:0010563	184	0.142
apoptotic mitochondrial changes	GO:0008637	48	0.141
regulation of myeloid leukocyte differentiation	GO:0002761	58	0.140	Mouse
positive regulation of neutrophil mediated cytotoxicity	GO:0070960	1	0.140
regulation of response to biotic stimulus	GO:0002831	38	0.138
cytoplasmic transport	GO:0016482	234	0.137
regulation of osteoclast differentiation	GO:0045670	36	0.134	Mouse
rhythmic process	GO:0048511	174	0.133	Fly
endocytosis	GO:0006897	168	0.132
release of cytochrome c from mitochondria	GO:0001836	23	0.132
mapk cascade	GO:0000165	281	0.132
negative regulation of phosphate metabolic process	GO:0045936	184	0.131
thymocyte migration	GO:0072679	2	0.130
vitellogenesis	GO:0007296	2	0.130	Mouse
t cell activation	GO:0042110	289	0.128
circadian rhythm	GO:0007623	114	0.126	Fly
cd4 positive alpha beta t cell cytokine production	GO:0035743	4	0.126
regulation of plasminogen activation	GO:0010755	4	0.124
regulation of transforming growth factor beta2 production	GO:0032909	2	0.124
regulation of organelle organization	GO:0033043	289	0.123	Mouse
positive regulation of monocyte chemotaxis	GO:0090026	2	0.123
ribose phosphate metabolic process	GO:0019693	291	0.123
skeletal muscle cell differentiation	GO:0035914	66	0.122
cation homeostasis	GO:0055080	212	0.122
compound eye development	GO:0048749	1	0.122	Fly
viral gene expression	GO:0019080	3	0.122
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.121
embryonic process involved in female pregnancy	GO:0060136	7	0.121
aromatic compound catabolic process	GO:0019439	286	0.121
regulation of neuron death	GO:1901214	134	0.120
regulation of neutrophil mediated killing of symbiont cell	GO:0070949	2	0.120
positive regulation of organelle organization	GO:0010638	128	0.119	Mouse
histone deacetylation	GO:0016575	26	0.119	Mouse
positive regulation of rho gtpase activity	GO:0032321	41	0.118
regulation of protein autophosphorylation	GO:0031952	8	0.118
central nervous system segmentation	GO:0035283	3	0.118
neuron apoptotic process	GO:0051402	142	0.117
response to drug	GO:0042493	75	0.116	Mouse
organic cyclic compound catabolic process	GO:1901361	295	0.116
modification of morphology or physiology of other organism involved in symbiotic interaction	GO:0051817	16	0.116
nucleoside metabolic process	GO:0009116	246	0.115
interleukin 8 production	GO:0032637	4	0.115
cellular nitrogen compound catabolic process	GO:0044270	280	0.115
response to inorganic substance	GO:0010035	96	0.114	Mouse
positive regulation of gtp catabolic process	GO:0033126	85	0.114
neuron projection regeneration	GO:0031102	14	0.114	Fly
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.114
positive regulation of epithelial cell proliferation	GO:0050679	68	0.113
purine containing compound metabolic process	GO:0072521	311	0.112
nucleotide metabolic process	GO:0009117	332	0.111
negative regulation of fat cell differentiation	GO:0045599	36	0.111	Mouse
regulation of response to wounding	GO:1903034	189	0.111
regulation of membrane potential	GO:0042391	192	0.110
phagocytosis	GO:0006909	66	0.108
axon regeneration	GO:0031103	12	0.107	Fly
regulation of angiogenesis	GO:0045765	81	0.107
apoptotic signaling pathway	GO:0097190	306	0.107
lymphocyte differentiation	GO:0030098	242	0.107
monosaccharide biosynthetic process	GO:0046364	44	0.107
cellular response to lipopolysaccharide	GO:0071222	77	0.106
regulation of interleukin 8 production	GO:0032677	3	0.106
response to mineralocorticoid	GO:0051385	1	0.106
reactive oxygen species metabolic process	GO:0072593	84	0.106
labyrinthine layer blood vessel development	GO:0060716	21	0.106
regulation of chromatin modification	GO:1903308	57	0.106	Mouse
mitotic cell cycle	GO:0000278	195	0.106	Fly
positive regulation of cellular catabolic process	GO:0031331	148	0.105
neuron death	GO:0070997	154	0.105
striated muscle cell development	GO:0055002	125	0.103
camera type eye development	GO:0043010	266	0.103
positive regulation of histone modification	GO:0031058	28	0.103	Mouse
regulation of protein deacetylation	GO:0090311	17	0.103	Mouse
negative regulation of neuron death	GO:1901215	98	0.102
learning	GO:0007612	98	0.102
leukocyte homeostasis	GO:0001776	79	0.102
regulation of leukocyte apoptotic process	GO:2000106	56	0.101
myeloid leukocyte differentiation	GO:0002573	119	0.101	Mouse
embryonic placenta development	GO:0001892	98	0.101
regulation of mapk cascade	GO:0043408	248	0.100
rhombomere 5 development	GO:0021571	4	0.099
regulation of gtp catabolic process	GO:0033124	113	0.097
forebrain development	GO:0030900	302	0.097
glycosyl compound catabolic process	GO:1901658	206	0.096
macromolecule deacylation	GO:0098732	37	0.095	Mouse
negative regulation of metanephric glomerular mesangial cell proliferation	GO:0072302	1	0.093
purine nucleotide catabolic process	GO:0006195	211	0.092
labyrinthine layer development	GO:0060711	49	0.092
developmental maturation	GO:0021700	193	0.092
regulation of nucleoside metabolic process	GO:0009118	130	0.091
positive regulation of protein kinase activity	GO:0045860	144	0.091
activation of mapkkk activity	GO:0000185	1	0.091
regulation of ossification	GO:0030278	112	0.091
regulation of rho gtpase activity	GO:0032319	58	0.090
regulation of ras gtpase activity	GO:0032318	88	0.090
positive regulation of nucleotide catabolic process	GO:0030813	88	0.090
positive regulation of neuron death	GO:1901216	28	0.090
negative regulation of respiratory burst involved in inflammatory response	GO:0060266	1	0.089
regulation of protein serine threonine kinase activity	GO:0071900	157	0.088	Fly
chromatin modification	GO:0016568	187	0.086	Mouse
regulation of cellular response to stress	GO:0080135	159	0.085
guanosine containing compound catabolic process	GO:1901069	144	0.085
positive regulation of nucleoside metabolic process	GO:0045979	91	0.085
glucose metabolic process	GO:0006006	92	0.085
positive regulation of nucleotide metabolic process	GO:0045981	114	0.083
positive regulation of protein phosphorylation	GO:0001934	242	0.083
gland development	GO:0048732	330	0.083
mitotic cell cycle process	GO:1903047	159	0.083	Fly
dna metabolic process	GO:0006259	303	0.083
cellular response to follicle stimulating hormone stimulus	GO:0071372	1	0.083
modification of morphology or physiology of other organism	GO:0035821	18	0.082
response to oxidative stress	GO:0006979	123	0.082
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.082
guanosine containing compound metabolic process	GO:1901068	144	0.081
regulation of hydrolase activity	GO:0051336	246	0.081
response to calcium ion	GO:0051592	20	0.081	Mouse
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.081
response to organonitrogen compound	GO:0010243	246	0.081
cellular response to growth factor stimulus	GO:0071363	197	0.081
regulation of respiratory burst involved in inflammatory response	GO:0060264	2	0.081
regulation of chromosome organization	GO:0033044	83	0.080	Mouse
nucleoside triphosphate catabolic process	GO:0009143	205	0.080
response to extracellular stimulus	GO:0009991	127	0.079	Mouse
regulation of ovulation	GO:0060278	3	0.079
regulation of dna templated transcription in response to stress	GO:0043620	9	0.079
regulation of chromatin organization	GO:1902275	57	0.079	Mouse
purine containing compound catabolic process	GO:0072523	213	0.078
histone modification	GO:0016570	159	0.078	Mouse
regulation of histone modification	GO:0031056	56	0.078	Mouse
modification by host of symbiont morphology or physiology	GO:0051851	12	0.078
positive regulation of chromatin modification	GO:1903310	28	0.078	Mouse
cellular response to external stimulus	GO:0071496	88	0.077	Mouse
regulation of rho protein signal transduction	GO:0035023	71	0.077
positive regulation of hematopoietic stem cell proliferation	GO:1902035	2	0.077
amine metabolic process	GO:0009308	45	0.077
adaptive immune response	GO:0002250	155	0.076
positive regulation of blood circulation	GO:1903524	22	0.076
cellular response to oxidative stress	GO:0034599	76	0.075
cellular response to metal ion	GO:0071248	31	0.074	Mouse
response to camp	GO:0051591	14	0.074
positive regulation of osteoclast differentiation	GO:0045672	15	0.073	Mouse
inflammatory response	GO:0006954	244	0.073
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.073
ceramide biosynthetic process	GO:0046513	20	0.072
heart contraction	GO:0060047	93	0.072
germ cell development	GO:0007281	185	0.071	Fly
negative regulation of inflammatory response	GO:0050728	61	0.071
synapse organization	GO:0050808	125	0.071	Fly
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.071
decidualization	GO:0046697	10	0.070
membrane lipid biosynthetic process	GO:0046467	32	0.070
rho protein signal transduction	GO:0007266	32	0.070
viral process	GO:0016032	41	0.070
positive regulation of leukocyte mediated cytotoxicity	GO:0001912	31	0.070
circulatory system process	GO:0003013	197	0.070
regulation of lymphocyte activation	GO:0051249	240	0.069
negative regulation of ovulation	GO:0060280	1	0.068
cellular response to molecule of bacterial origin	GO:0071219	83	0.068
macrophage activation	GO:0042116	27	0.068
cellular response to calcium ion	GO:0071277	14	0.068	Mouse
general adaptation syndrome	GO:0051866	2	0.067
muscle cell development	GO:0055001	133	0.067
cellular response to dna damage stimulus	GO:0006974	207	0.067
purine nucleoside catabolic process	GO:0006152	205	0.067
humoral immune response	GO:0006959	57	0.067	Fly
mrna 3 end processing	GO:0031124	16	0.066
central nervous system neuron development	GO:0021954	67	0.066
response to reactive oxygen species	GO:0000302	56	0.066
cellular response to organic cyclic compound	GO:0071407	87	0.066
connective tissue development	GO:0061448	179	0.066
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.065
t helper 2 cell cytokine production	GO:0035745	4	0.065
regulation of rhodopsin gene expression	GO:0007468	3	0.065
metanephric glomerular mesangium development	GO:0072223	3	0.065
regulation of eosinophil migration	GO:2000416	2	0.065
regulation of ras protein signal transduction	GO:0046578	114	0.065
purine ribonucleoside catabolic process	GO:0046130	205	0.064
regulation of ion transport	GO:0043269	215	0.064
epithelial cell proliferation	GO:0050673	174	0.064
blood circulation	GO:0008015	195	0.064
positive regulation of purine nucleotide catabolic process	GO:0033123	88	0.063
negative regulation of protein phosphorylation	GO:0001933	126	0.063
regulation of adaptive immune response	GO:0002819	90	0.063
cellular response to lipid	GO:0071396	145	0.063
transmembrane transport	GO:0055085	412	0.063
negative regulation of defense response	GO:0031348	77	0.062
ribonucleoside catabolic process	GO:0042454	206	0.062
ribonucleoside metabolic process	GO:0009119	245	0.062
circadian behavior	GO:0048512	13	0.062	Fly
organophosphate catabolic process	GO:0046434	232	0.062
regulation of defense response to fungus	GO:1900150	1	0.061
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.061
cell cycle g2 m phase transition	GO:0044839	20	0.060	Fly
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.060
fibrinolysis	GO:0042730	3	0.059
regulation of purine nucleotide catabolic process	GO:0033121	122	0.059
intracellular protein transport	GO:0006886	204	0.059
regulation of protein maturation	GO:1903317	96	0.059
glial cell differentiation	GO:0010001	131	0.059
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.058
viral life cycle	GO:0019058	36	0.058
purine ribonucleotide catabolic process	GO:0009154	208	0.057
macromolecule methylation	GO:0043414	120	0.057
axonogenesis	GO:0007409	274	0.057	Fly
adrenal cortex development	GO:0035801	2	0.057
response to nutrient levels	GO:0031667	109	0.057
regulation of neutrophil mediated cytotoxicity	GO:0070948	2	0.057
regulation of fibrinolysis	GO:0051917	1	0.057
positive regulation of kinase activity	GO:0033674	155	0.056
chemotaxis	GO:0006935	247	0.056
negative regulation of immune system process	GO:0002683	209	0.056
purine nucleoside metabolic process	GO:0042278	241	0.055
ribonucleotide metabolic process	GO:0009259	291	0.054
tumor necrosis factor production	GO:0032640	50	0.054
regulation of myeloid cell differentiation	GO:0045637	96	0.054	Mouse
cd4 positive alpha beta t cell differentiation	GO:0043367	41	0.053
gtp metabolic process	GO:0046039	144	0.053
blastocyst development	GO:0001824	80	0.053
muscle cell differentiation	GO:0042692	261	0.053
skeletal system development	GO:0001501	356	0.053
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.052
fertilization	GO:0009566	127	0.052
regulation of viral transcription	GO:0046782	3	0.052
cell growth	GO:0016049	130	0.052	Fly
purine ribonucleoside metabolic process	GO:0046128	241	0.052
regulation of fat cell differentiation	GO:0045598	81	0.052	Mouse
positive regulation of eosinophil migration	GO:2000418	2	0.052
regulation of respiratory burst	GO:0060263	2	0.052
negative regulation of viral process	GO:0048525	23	0.052
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.052
negative regulation of jun kinase activity	GO:0043508	9	0.051
response to steroid hormone	GO:0048545	56	0.051
protein localization to organelle	GO:0033365	185	0.051
learning or memory	GO:0007611	148	0.051
homeostasis of number of cells	GO:0048872	210	0.051
regulation of heart contraction	GO:0008016	77	0.051
synapse assembly	GO:0007416	56	0.050	Fly
sensory system development	GO:0048880	3	0.050
regulation of protein localization	GO:0032880	231	0.050
cognition	GO:0050890	149	0.050
ossification	GO:0001503	216	0.049
adipose tissue development	GO:0060612	25	0.049
male gamete generation	GO:0048232	285	0.049
regulation of cell motility	GO:2000145	236	0.049
ribonucleotide catabolic process	GO:0009261	208	0.048
gtp catabolic process	GO:0006184	143	0.048
membrane depolarization	GO:0051899	64	0.048
negative regulation of protein serine threonine kinase activity	GO:0071901	49	0.048
negative regulation of intracellular signal transduction	GO:1902532	167	0.048
regulation of hematopoietic stem cell proliferation	GO:1902033	3	0.048
regulation of thymocyte migration	GO:2000410	2	0.048
positive regulation of b cell chemotaxis	GO:2000538	2	0.048
positive regulation of chromosome organization	GO:2001252	33	0.048	Mouse
cell adhesion	GO:0007155	329	0.047
establishment of protein localization to organelle	GO:0072594	118	0.047
regulation of cell activation	GO:0050865	289	0.046
gene silencing by mirna	GO:0035195	10	0.046
positive regulation of myeloid cell differentiation	GO:0045639	43	0.046	Mouse
carbohydrate derivative catabolic process	GO:1901136	231	0.046
regulation of neutrophil mediated killing of fungus	GO:0070953	1	0.046
positive regulation of hydrolase activity	GO:0051345	148	0.046
protein autophosphorylation	GO:0046777	61	0.046
cellular response to cytokine stimulus	GO:0071345	189	0.046
cellular response to extracellular stimulus	GO:0031668	81	0.046	Mouse
nucleotide catabolic process	GO:0009166	217	0.045
regulation of symbiosis encompassing mutualism through parasitism	GO:0043903	52	0.045
regulation of apoptotic signaling pathway	GO:2001233	197	0.045
calcium ion transport	GO:0006816	159	0.045
positive regulation of sphingolipid biosynthetic process	GO:0090154	1	0.045
angiogenesis	GO:0001525	201	0.045
regulation of t cell activation	GO:0050863	170	0.045
maternal process involved in female pregnancy	GO:0060135	32	0.045
rhombomere 5 formation	GO:0021666	1	0.045
positive regulation of transcription from rna polymerase ii promoter in response to stress	GO:0036003	3	0.045
regulation of myotube differentiation	GO:0010830	62	0.044
maternal placenta development	GO:0001893	20	0.044
nuclear transcribed mrna poly a tail shortening	GO:0000289	7	0.044
organonitrogen compound catabolic process	GO:1901565	264	0.044
skeletal muscle fiber development	GO:0048741	58	0.043
response to growth factor	GO:0070848	198	0.043
negative regulation of neuron apoptotic process	GO:0043524	92	0.043
gliogenesis	GO:0042063	141	0.043
defense response to bacterium	GO:0042742	119	0.043
negative regulation of proteolysis	GO:0045861	74	0.043
nucleoside triphosphate metabolic process	GO:0009141	230	0.042
negative regulation of cell cycle	GO:0045786	123	0.042
regulation of defense response to bacterium	GO:1900424	3	0.042
cellular amine metabolic process	GO:0044106	44	0.042
multicellular organismal homeostasis	GO:0048871	164	0.042
protein modification by small protein conjugation	GO:0032446	187	0.042
negative regulation of endopeptidase activity	GO:0010951	44	0.041
negative regulation of cyclin dependent protein serine threonine kinase activity	GO:0045736	9	0.041
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.041
regulation of map kinase activity	GO:0043405	120	0.040
nucleoside phosphate catabolic process	GO:1901292	222	0.040
nucleoside catabolic process	GO:0009164	206	0.040
alpha beta t cell activation	GO:0046631	91	0.040
arachidonic acid metabolite production involved in inflammatory response	GO:0002538	2	0.039
developmental growth involved in morphogenesis	GO:0060560	138	0.039	Fly
carbohydrate metabolic process	GO:0005975	230	0.039
positive regulation of mitochondrial membrane permeability involved in apoptotic process	GO:1902110	11	0.039
leukocyte activation involved in immune response	GO:0002366	126	0.039
response to light stimulus	GO:0009416	135	0.039
rna processing	GO:0006396	105	0.038
positive regulation of osteoblast differentiation	GO:0045669	34	0.038
viral transcription	GO:0019083	3	0.038
response to corticosterone	GO:0051412	1	0.038
regulation of cellular component biogenesis	GO:0044087	181	0.038
positive regulation of gtpase activity	GO:0043547	85	0.038
liver development	GO:0001889	66	0.038
regulation of osteoblast differentiation	GO:0045667	67	0.037
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.037
cellular amino acid metabolic process	GO:0006520	103	0.037
heart morphogenesis	GO:0003007	178	0.037
response to catecholamine	GO:0071869	4	0.037
innate immune response	GO:0045087	157	0.037
blastocyst formation	GO:0001825	33	0.037
nuclear transcribed mrna catabolic process	GO:0000956	16	0.036
alpha beta t cell differentiation involved in immune response	GO:0002293	30	0.036
canonical wnt signaling pathway	GO:0060070	130	0.036
smad protein signal transduction	GO:0060395	21	0.036
response to starvation	GO:0042594	65	0.036
negative regulation of innate immune response	GO:0045824	17	0.036
response to purine containing compound	GO:0014074	28	0.036
regulation of muscle tissue development	GO:1901861	97	0.035
monosaccharide metabolic process	GO:0005996	106	0.035
hexose metabolic process	GO:0019318	98	0.035
cellular calcium ion homeostasis	GO:0006874	119	0.035
positive regulation of syncytium formation by plasma membrane fusion	GO:0060143	17	0.035
negative regulation of cellular component organization	GO:0051129	194	0.035
regulation of stress activated mapk cascade	GO:0032872	69	0.035
regulation of neuron projection development	GO:0010975	169	0.034
negative regulation of protein autophosphorylation	GO:0031953	2	0.034
rhombomere morphogenesis	GO:0021593	2	0.034
stress activated mapk cascade	GO:0051403	80	0.034
muscle cell proliferation	GO:0033002	52	0.033
positive regulation of cell motility	GO:2000147	116	0.033
neural tube development	GO:0021915	160	0.033
positive regulation of cell killing	GO:0031343	33	0.033
protein import into nucleus	GO:0006606	95	0.033
regulation of killing of cells of other organism	GO:0051709	4	0.033
response to organophosphorus	GO:0046683	22	0.033
negative regulation of cellular amine metabolic process	GO:0033239	1	0.033
protein deacetylation	GO:0006476	32	0.033	Mouse
negative regulation of cell proliferation	GO:0008285	296	0.033
metal ion homeostasis	GO:0055065	189	0.033
divalent inorganic cation transport	GO:0072511	178	0.033
extrinsic apoptotic signaling pathway	GO:0097191	126	0.032
positive regulation of transcription from rna polymerase i promoter	GO:0045943	3	0.032
g2 m transition of mitotic cell cycle	GO:0000086	20	0.032	Fly
mrna processing	GO:0006397	63	0.032
cell maturation	GO:0048469	127	0.032
regulation of striated muscle cell differentiation	GO:0051153	81	0.032
alpha beta t cell differentiation	GO:0046632	69	0.032
regulation of skeletal muscle fiber development	GO:0048742	36	0.032
regulation of ion transmembrane transport	GO:0034765	119	0.031
negative regulation of metanephric glomerulus development	GO:0072299	1	0.031
t cell activation involved in immune response	GO:0002286	43	0.031
positive regulation of mapk cascade	GO:0043410	170	0.031
regulation of alpha beta t cell differentiation	GO:0046637	35	0.031
rna stabilization	GO:0043489	9	0.031
positive regulation of defense response	GO:0031349	124	0.031
adrenal cortex formation	GO:0035802	2	0.031
regulation of system process	GO:0044057	200	0.031
positive regulation of cell activation	GO:0050867	158	0.031
female gamete generation	GO:0007292	74	0.031	Mouse Fly
positive regulation of neutrophil mediated killing of fungus	GO:0070965	1	0.031
organelle assembly	GO:0070925	177	0.030
negative regulation of t helper 2 cell differentiation	GO:0045629	4	0.030
regulation of monocyte chemotaxis	GO:0090025	3	0.030
sperm motility	GO:0030317	47	0.030
carbohydrate biosynthetic process	GO:0016051	74	0.030
cellular ion homeostasis	GO:0006873	165	0.030
protein ubiquitination	GO:0016567	171	0.030
rna 3 end processing	GO:0031123	20	0.030
nucleocytoplasmic transport	GO:0006913	139	0.029
cellular chemical homeostasis	GO:0055082	215	0.029
chondrocyte differentiation	GO:0002062	72	0.029
negative regulation of muscle cell differentiation	GO:0051148	33	0.029
cellular response to nutrient levels	GO:0031669	64	0.029
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.029
glomerular mesangial cell proliferation	GO:0072110	3	0.029
negative regulation of cell activation	GO:0050866	111	0.029
skin development	GO:0043588	220	0.029
positive regulation of t helper 2 cell cytokine production	GO:2000553	3	0.029
regulation of cell migration involved in sprouting angiogenesis	GO:0090049	4	0.029
response to hydrogen peroxide	GO:0042542	32	0.029
macromolecule catabolic process	GO:0009057	281	0.029
membrane organization	GO:0061024	245	0.029
regulation of ceramide biosynthetic process	GO:2000303	1	0.029
chorio allantoic fusion	GO:0060710	8	0.029
myotube cell development	GO:0014904	60	0.029

Atf3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.072
nervous system disease	DOID:863	0.072
neuropathy	DOID:870	0.072
neuromuscular disease	DOID:440	0.059
cancer	DOID:162	0.037
disease of cellular proliferation	DOID:14566	0.037
organ system cancer	DOID:0050686	0.034
charcot marie tooth disease	DOID:10595	0.033

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