Mus musculus

22 known processes

Itm2b

integral membrane protein 2B

(Aliases: E25BMM,Bri2,AI256040,D14Sel6)

Itm2b biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
positive regulation of leukocyte mediated cytotoxicityGO:0001912310.465
rna polyadenylationGO:004363160.287
regulation of apoptotic signaling pathwayGO:20012331970.236
Mouse
cation homeostasisGO:00550802120.230
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathwayGO:004316230.205
copper ion homeostasisGO:005507090.195
metal ion homeostasisGO:00550651890.184
selenium compound metabolic processGO:000188730.181
endoplasmic reticulum calcium ion homeostasisGO:0032469110.178
cellular amine metabolic processGO:0044106440.159
regulation of leukocyte mediated immunityGO:00027031040.155
regulation of leukocyte mediated cytotoxicityGO:0001910380.154
immune effector processGO:00022523210.143
regulation of cellular amino acid metabolic processGO:000652150.141
positive regulation of t cell mediated cytotoxicityGO:0001916150.136
cellular ketone metabolic processGO:0042180840.130
amine metabolic processGO:0009308450.124
regulation of protein stabilityGO:0031647520.117
iron ion homeostasisGO:0055072360.116
cellular macromolecule catabolic processGO:00442652060.111
regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathwayGO:1902235110.110
cellular protein catabolic processGO:00442571550.108
apoptotic signaling pathwayGO:00971903060.106
cellular metal ion homeostasisGO:00068751510.105
regulation of protein maturationGO:1903317960.098
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.097
oxidation reduction processGO:00551143420.089
negative regulation of glycoprotein metabolic processGO:190301930.088
Human
glycerolipid metabolic processGO:00464861220.088
locomotory behaviorGO:00076261950.088
cellular homeostasisGO:00197252400.087
protein processingGO:00164851630.086
regulation of epidermal growth factor activated receptor activityGO:000717670.085
ensheathment of neuronsGO:0007272760.083
cellular transition metal ion homeostasisGO:0046916320.082
tissue remodelingGO:00487711020.079
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.079
cellular amino acid metabolic processGO:00065201030.078
transition metal ion homeostasisGO:0055076540.076
negative regulation of cell proliferationGO:00082852960.074
phospholipid metabolic processGO:0006644870.073
regulation of lymphocyte mediated immunityGO:0002706840.073
positive regulation of cell killingGO:0031343330.073
mrna 3 end processingGO:0031124160.071
regulation of t cell mediated cytotoxicityGO:0001914180.069
regulation of membrane potentialGO:00423911920.069
rna 3 end processingGO:0031123200.067
ossificationGO:00015032160.067
negative regulation of proteolysisGO:0045861740.066
leukocyte mediated immunityGO:00024431740.065
cellular chemical homeostasisGO:00550822150.065
cellular copper ion homeostasisGO:000687880.065
regulation of peptidase activityGO:0052547960.062
cellular amino acid catabolic processGO:0009063250.062
response to oxidative stressGO:00069791230.062
protein maturationGO:00516041760.062
multicellular organismal catabolic processGO:004424370.062
mrna polyadenylationGO:000637850.060
leukocyte mediated cytotoxicityGO:0001909620.060
regulation of protein processingGO:0070613960.059
myelinationGO:0042552740.056
macromolecule catabolic processGO:00090572810.056
leukocyte activation involved in immune responseGO:00023661260.056
carbohydrate derivative catabolic processGO:19011362310.056
positive regulation of apoptotic signaling pathwayGO:2001235950.055
Mouse
response to organic cyclic compoundGO:00140701980.055
alcohol metabolic processGO:00060661160.054
response to steroid hormoneGO:0048545560.051
cation transportGO:00068123990.050
transmembrane transportGO:00550854120.050
cellular lipid metabolic processGO:00442553230.049
muscle tissue developmentGO:00605373080.049
regulation of adaptive immune responseGO:0002819900.049
cellular ion homeostasisGO:00068731650.048
developmental maturationGO:00217001930.047
regulation of cellular ketone metabolic processGO:0010565660.047
posttranscriptional regulation of gene expressionGO:00106081550.046
negative regulation of protein metabolic processGO:00512482820.046
Human
extracellular structure organizationGO:00430621480.045
heterocycle catabolic processGO:00467002800.045
reactive nitrogen species metabolic processGO:200105700.044
b cell activation involved in immune responseGO:0002312500.044
lymphocyte activation involved in immune responseGO:0002285930.044
t cell mediated immunityGO:0002456500.044
positive regulation of apoptotic processGO:00430652170.044
Mouse
nucleobase containing small molecule metabolic processGO:00550863520.044
organic hydroxy compound metabolic processGO:19016152030.043
regulation of lymphocyte activationGO:00512492400.043
regulation of gamma aminobutyric acid secretionGO:001405220.042
circadian sleep wake cycle rem sleepGO:004274710.041
multi multicellular organism processGO:00447061090.041
proteolysis involved in cellular protein catabolic processGO:00516031470.041
positive regulation of cellular amino acid metabolic processGO:004576430.040
transmission of nerve impulseGO:0019226760.040
response to organonitrogen compoundGO:00102432460.039
microtubule based processGO:00070172360.038
cytokine productionGO:00018163190.038
t cell proliferationGO:00420981200.038
regulation of defense responseGO:00313472330.037
skeletal system developmentGO:00015013560.037
negative regulation of t cell activationGO:0050868650.037
protein modification by small protein conjugationGO:00324461870.036
negative regulation of protein processingGO:0010955790.036
antigen processing and presentation of exogenous peptide antigen via mhc class ibGO:000247730.036
membrane lipid biosynthetic processGO:0046467320.035
negative regulation of protein maturationGO:1903318790.035
cellular response to oxidative stressGO:0034599760.034
peptidyl tyrosine modificationGO:00182121450.034
cell activation involved in immune responseGO:00022631260.033
negative regulation of cellular catabolic processGO:0031330470.033
positive regulation of defense responseGO:00313491240.033
axon ensheathmentGO:0008366760.033
anatomical structure homeostasisGO:00602491450.032
adaptive immune responseGO:00022501550.032
positive regulation of protein modification processGO:00314012990.032
neuromuscular process controlling balanceGO:0050885590.032
regulation of cellular amine metabolic processGO:0033238200.031
nitrogen compound transportGO:00717052710.031
regulation of cellular catabolic processGO:00313292420.031
regulation of protein catabolic processGO:00421761080.031
calcium ion homeostasisGO:00550741270.031
regulation of receptor activityGO:0010469410.031
epidermis developmentGO:00085441870.030
t cell mediated cytotoxicityGO:0001913260.030
negative regulation of cell activationGO:00508661110.030
regulation of intrinsic apoptotic signaling pathwayGO:2001242610.030
regulation of cell killingGO:0031341400.030
regulation of systemic arterial blood pressure by carotid body chemoreceptor signalingGO:000302710.029
lymphocyte mediated immunityGO:00024491390.029
peptide metabolic processGO:0006518460.029
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.029
synaptic transmissionGO:00072683290.029
connective tissue developmentGO:00614481790.028
protein catabolic processGO:00301632210.028
cation transmembrane transportGO:00986552660.028
regulation of cell cycle processGO:00105641600.028
positive regulation of g2 m transition of mitotic cell cycleGO:001097150.028
peptidyl tyrosine phosphorylationGO:00181081430.027
bone developmentGO:00603481200.027
regulation of hormone levelsGO:00108172110.027
cellular divalent inorganic cation homeostasisGO:00725031270.027
organic cyclic compound catabolic processGO:19013612950.026
regulation of lymphocyte proliferationGO:00506701170.026
glycosyl compound catabolic processGO:19016582060.026
mrna metabolic processGO:0016071840.025
endomembrane system organizationGO:00102561470.025
cell adhesionGO:00071553290.025
modification dependent macromolecule catabolic processGO:00436321330.025
endocytosisGO:00068971680.025
intrinsic apoptotic signaling pathwayGO:00971931320.025
negative regulation of cytokine productionGO:0001818840.025
protein ubiquitinationGO:00165671710.024
positive regulation of secretionGO:00510471300.024
opsonizationGO:000822830.024
maintenance of locationGO:0051235890.024
negative regulation of cellular protein metabolic processGO:00322692470.024
adult locomotory behaviorGO:0008344910.024
dna recombinationGO:0006310920.024
ribonucleoside metabolic processGO:00091192450.024
neuronal action potentialGO:0019228540.024
action potentialGO:0001508780.024
negative regulation of cellular component organizationGO:00511291940.023
multicellular organismal signalingGO:0035637910.023
nucleotide metabolic processGO:00091173320.023
establishment of vesicle localizationGO:0051650810.023
neuromuscular processGO:0050905990.023
amino acid transportGO:0006865610.023
regulation of intracellular transportGO:00323861590.022
aromatic compound catabolic processGO:00194392860.022
sterol metabolic processGO:0016125580.022
cellular nitrogen compound catabolic processGO:00442702800.022
isoprenoid metabolic processGO:0006720290.022
defense response to other organismGO:00985421970.021
regulation of cellular response to stressGO:00801351590.021
reactive oxygen species biosynthetic processGO:190340980.021
glycerophospholipid metabolic processGO:0006650710.021
spermatogenesisGO:00072832840.021
male gonad developmentGO:0008584880.021
phospholipid transfer to membraneGO:000664920.021
ionotropic glutamate receptor signaling pathwayGO:0035235290.021
regulation of t cell mediated immunityGO:0002709340.021
stem cell differentiationGO:00488632680.021
regulation of neuron differentiationGO:00456642810.021
positive regulation of hydrolase activityGO:00513451480.021
regulation of inflammatory responseGO:00507271470.021
multicellular organismal macromolecule metabolic processGO:0044259190.021
somatic recombination of immunoglobulin genes involved in immune responseGO:0002204360.021
lipid transportGO:0006869980.020
mitotic cell cycle processGO:19030471590.020
pole plasm assemblyGO:000731520.020
cellular protein complex assemblyGO:00436231160.020
regulation of synaptic plasticityGO:0048167870.020
inflammatory responseGO:00069542440.020
regulation of mitotic cell cycle phase transitionGO:1901990730.020
response to drugGO:0042493750.020
granzyme mediated apoptotic signaling pathwayGO:000862610.020
purine ribonucleoside metabolic processGO:00461282410.020
multicellular organismal metabolic processGO:0044236280.020
cellular calcium ion homeostasisGO:00068741190.020
positive regulation of cellular amine metabolic processGO:003324050.020
positive regulation of lymphocyte mediated immunityGO:0002708620.019
divalent inorganic cation homeostasisGO:00725071380.019
regulation of transferase activityGO:00513382630.019
purine ribonucleotide catabolic processGO:00091542080.019
rna processingGO:00063961050.019
carboxylic acid catabolic processGO:0046395510.019
cellular response to external stimulusGO:0071496880.019
gland developmentGO:00487323300.019
lipid biosynthetic processGO:00086101790.019
negative regulation of molecular functionGO:00440922580.019
regulation of endopeptidase activityGO:0052548890.019
regulation of cell motilityGO:20001452360.019
neuroblast division in subventricular zoneGO:002184920.019
cell maturationGO:00484691270.019
regulation of cytokine productionGO:00018172660.019
positive regulation of secretion by cellGO:19035321140.019
male gamete generationGO:00482322850.019
response to radiationGO:00093141650.019
positive regulation of programmed cell deathGO:00430682180.019
Mouse
positive regulation of reactive oxygen species metabolic processGO:2000379110.019
negative regulation of dna recombinationGO:0045910130.018
regulation of secretionGO:00510462740.018
t cell activationGO:00421102890.018
collagen catabolic processGO:003057460.018
dna replicationGO:0006260520.018
purine ribonucleoside catabolic processGO:00461302050.018
chemotaxisGO:00069352470.018
somatic cell dna recombinationGO:0016444510.018
neuron apoptotic processGO:00514021420.018
positive regulation of immune effector processGO:00026991070.018
regulation of reactive oxygen species biosynthetic processGO:190342620.018
circadian rhythmGO:00076231140.018
microtubule based transportGO:0010970500.018
negative regulation of endopeptidase activityGO:0010951440.018
ubiquitin dependent protein catabolic processGO:00065111290.017
nucleoside phosphate metabolic processGO:00067533380.017
negative regulation of leukocyte mediated immunityGO:0002704290.017
regulation of vascular smooth muscle contractionGO:000305610.017
regulation of proteolysisGO:00301621640.017
carbohydrate homeostasisGO:00335001280.017
circulatory system processGO:00030131970.017
regulation of ossificationGO:00302781120.017
learning or memoryGO:00076111480.017
purine nucleoside triphosphate catabolic processGO:00091462030.017
g protein coupled receptor signaling pathwayGO:00071862430.017
regulation of bindingGO:00510981110.017
positive regulation of intrinsic apoptotic signaling pathwayGO:2001244250.017
ribonucleotide catabolic processGO:00092612080.017
muscle cell differentiationGO:00426922610.017
organonitrogen compound biosynthetic processGO:19015661920.017
organophosphate ester transportGO:0015748280.017
positive regulation of cell deathGO:00109422240.017
Mouse
cognitionGO:00508901490.017
positive regulation of nervous system developmentGO:00519622210.017
hormone metabolic processGO:0042445860.017
gonad developmentGO:00084061410.017
regulation of glutamate secretionGO:001404830.016
nucleoside metabolic processGO:00091162460.016
regulation of endocytosisGO:0030100690.016
cytoskeleton dependent intracellular transportGO:0030705500.016
somatic recombination of immunoglobulin gene segmentsGO:0016447420.016
regulation of cell cycleGO:00517262810.016
cellular modified amino acid metabolic processGO:0006575630.016
coagulationGO:0050817780.016
mrna processingGO:0006397630.016
positive regulation of cell adhesionGO:0045785800.016
negative regulation of lymphocyte proliferationGO:0050672450.016
ribose phosphate metabolic processGO:00196932910.016
matingGO:0007618270.016
regulation of immunoglobulin productionGO:0002637420.015
regulation of response to woundingGO:19030341890.015
purine ribonucleoside monophosphate metabolic processGO:0009167800.015
microtubule based movementGO:0007018840.015
response to reactive oxygen speciesGO:0000302560.015
positive regulation of t cell mediated immunityGO:0002711240.015
regulation of neuron deathGO:19012141340.015
organic anion transportGO:00157111370.015
regulation of reactive oxygen species metabolic processGO:2000377400.015
production of molecular mediator of immune responseGO:00024401030.015
response to hypoxiaGO:0001666580.015
adult behaviorGO:00305341350.015
cellular response to thyroid hormone stimulusGO:009706710.015
positive regulation of innate immune responseGO:0045089800.015
myeloid cell differentiationGO:00300992330.015
nucleoside phosphate catabolic processGO:19012922220.015
negative regulation of lymphocyte mediated immunityGO:0002707210.015
reactive oxygen species metabolic processGO:0072593840.015
purine nucleotide metabolic processGO:00061633020.015
nucleoside catabolic processGO:00091642060.015
purine containing compound metabolic processGO:00725213110.015
response to molecule of bacterial originGO:00022371430.014
regulation of postsynaptic membrane potentialGO:0060078480.014
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathwayGO:000248430.014
negative regulation of t cell proliferationGO:0042130380.014
lymphocyte differentiationGO:00300982420.014
tissue homeostasisGO:00018941150.014
organic hydroxy compound transportGO:0015850930.014
leukocyte differentiationGO:00025213420.014
divalent inorganic cation transportGO:00725111780.014
wound healingGO:00420601570.014
innate immune responseGO:00450871570.014
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002824610.014
regulation of peptidyl tyrosine phosphorylationGO:0050730930.014
regulation of leukocyte proliferationGO:00706631210.014
regulation of protein localizationGO:00328802310.014
natural killer cell degranulationGO:004332030.014
regulation of neuron projection developmentGO:00109751690.014
fibril organizationGO:009743520.014
cellular response to hormone stimulusGO:00328701500.014
somatic diversification of immune receptorsGO:0002200530.014
positive regulation of protein catabolic processGO:0045732600.014
nucleoside triphosphate metabolic processGO:00091412300.014
protein autoprocessingGO:001654020.014
negative regulation of lymphocyte activationGO:0051250910.014
cellular response to lipidGO:00713961450.014
developmental growth involved in morphogenesisGO:00605601380.013
regulation of protein tyrosine kinase activityGO:0061097170.013
cellular biogenic amine metabolic processGO:0006576280.013
regulation of intracellular protein transportGO:0033157820.013
positive regulation of reactive oxygen species biosynthetic processGO:190342820.013
regulation of cell migrationGO:00303342190.013
negative regulation of neuron deathGO:1901215980.013
cellular response to drugGO:0035690150.013
learningGO:0007612980.013
pyruvate transportGO:000684820.013
iron ion import into cellGO:009745940.013
cellular response to extracellular stimulusGO:0031668810.013
regulation of b cell activationGO:0050864810.013
ear developmentGO:00435832000.013
positive regulation of lymphocyte activationGO:00512511400.013
striated muscle tissue developmentGO:00147062930.013
somatic diversification of immunoglobulinsGO:0016445430.013
dendrite developmentGO:00163581150.013
dna metabolic processGO:00062593030.013
organelle fissionGO:00482851700.013
regulation of transporter activityGO:0032409570.013
stem cell developmentGO:00488642190.013
nuclear divisionGO:00002801580.013
regulation of excitatory postsynaptic membrane potentialGO:0060079410.013
lymphocyte proliferationGO:00466511640.013
blood vessel morphogenesisGO:00485142850.013
antigen processing and presentation of endogenous peptide antigen via mhc class ib via er pathway tap dependentGO:000248920.013
immunoglobulin production involved in immunoglobulin mediated immune responseGO:0002381430.013
negative regulation of nervous system developmentGO:00519611560.013
response to inorganic substanceGO:0010035960.013
negative regulation of peptidase activityGO:0010466460.013
axonogenesisGO:00074092740.013
response to thyroid hormoneGO:009706620.013
sequestering of metal ionGO:0051238190.013
negative regulation of protein catabolic processGO:0042177360.012
memoryGO:0007613580.012
cellular response to growth factor stimulusGO:00713631970.012
negative regulation of apoptotic signaling pathwayGO:20012341040.012
synapse organizationGO:00508081250.012
regulation of multi organism processGO:00439001110.012
positive regulation of protein phosphorylationGO:00019342420.012
response to nutrient levelsGO:00316671090.012
male sex differentiationGO:00466611090.012
small molecule catabolic processGO:0044282710.012
biomineral tissue developmentGO:0031214640.012
cellular amide metabolic processGO:0043603580.012
response to lipopolysaccharideGO:00324961280.012
negative regulation of intracellular signal transductionGO:19025321670.012
interferon gamma productionGO:0032609670.012
negative regulation of neuron differentiationGO:00456651010.012
collagen metabolic processGO:0032963170.012
ribonucleoside triphosphate catabolic processGO:00092031990.012
response to light stimulusGO:00094161350.012
positive regulation of cytokine productionGO:00018191740.012
glycoprotein catabolic processGO:000651650.012
forebrain developmentGO:00309003020.012
negative regulation of cell developmentGO:00107211690.012
regulation of natural killer cell mediated immunityGO:0002715190.012
antigen processing and presentation of exogenous protein antigen via mhc class ib tap dependentGO:000248130.011
somatic diversification of immune receptors via germline recombination within a single locusGO:0002562510.011
immunoglobulin productionGO:0002377730.011
regulation of mapk cascadeGO:00434082480.011
regulation of leukocyte differentiationGO:19021051590.011
regulation of interferon gamma productionGO:0032649570.011
neuron deathGO:00709971540.011
regulation of cell cycle phase transitionGO:1901987770.011
ribonucleotide metabolic processGO:00092592910.011
cell cycle g2 m phase transitionGO:0044839200.011
embryonic organ morphogenesisGO:00485622760.011
cell killingGO:0001906670.011
regulation of body fluid levelsGO:00508781620.011
response to endoplasmic reticulum stressGO:0034976530.011
organonitrogen compound catabolic processGO:19015652640.011
regulation of kinase activityGO:00435492490.011
mitotic cell cycleGO:00002781950.011
protein modification by small protein conjugation or removalGO:00706472070.011
protein stabilizationGO:0050821250.011
cellular alcohol metabolic processGO:004410730.011
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.011
regulation of protein bindingGO:0043393600.011
intracellular cholesterol transportGO:003236730.011
regulation of interleukin 4 productionGO:0032673180.011
negative regulation of response to woundingGO:1903035770.011
negative regulation of leukocyte proliferationGO:0070664460.011
anion transportGO:00068201770.011
negative regulation of cell cycleGO:00457861230.011
cell recognitionGO:0008037830.011
cell type specific apoptotic processGO:00972852680.011
regulation of cytoplasmic transportGO:19036491120.011
b cell mediated immunityGO:0019724710.011
peptidyl amino acid modificationGO:00181933360.010
keratinocyte proliferationGO:0043616210.010
response to peptideGO:19016521360.010
negative regulation of phosphate metabolic processGO:00459361840.010
development of primary male sexual characteristicsGO:0046546880.010
regulation of cell activationGO:00508652890.010
mating behaviorGO:0007617200.010
membrane depolarizationGO:0051899640.010
defense response to bacteriumGO:00427421190.010
small molecule biosynthetic processGO:00442831320.010
rhythmic processGO:00485111740.010
hatchingGO:003518840.010
cytokine production involved in immune responseGO:0002367340.010
regulation of erbb signaling pathwayGO:1901184160.010
positive regulation of adaptive immune responseGO:0002821610.010

Itm2b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.981
Human
lysosomal storage diseaseDOID:321100.613
inherited metabolic disorderDOID:65500.613
amyloidosisDOID:912000.358
Human
acquired metabolic diseaseDOID:006015800.358
Human
disease of anatomical entityDOID:700.209
eye and adnexa diseaseDOID:149200.209
nervous system diseaseDOID:86300.209
eye diseaseDOID:561400.209
retinal diseaseDOID:567900.209
retinal degenerationDOID:846600.209
sensory system diseaseDOID:005015500.209
central nervous system diseaseDOID:33100.074
brain diseaseDOID:93600.074
neurodegenerative diseaseDOID:128900.043
cognitive disorderDOID:156100.043
disease of mental healthDOID:15000.043
tauopathyDOID:68000.043
alzheimer s diseaseDOID:1065200.043
dementiaDOID:130700.043
lipid storage diseaseDOID:945500.028
sphingolipidosisDOID:192700.023
degeneration of macula and posterior poleDOID:200700.015
age related macular degenerationDOID:1087100.015
macular degenerationDOID:444800.015
musculoskeletal system diseaseDOID:1700.012
bone diseaseDOID:008000100.012
bone development diseaseDOID:008000600.012
connective tissue diseaseDOID:6500.012
lipid metabolism disorderDOID:314600.011
immune system diseaseDOID:291400.011
hematopoietic system diseaseDOID:7400.011