IMP: Integrative Multi-species Prediction

Mus musculus

62 known processes

Tlr1

toll-like receptor 1

Ensembl: ENSMUSG00000044827
Entrez: 21897
UniProtKB: B9EJ46
UniProtKB: Q9EPQ1

Process Predictions
Disease Predictions

Tlr1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
defense response to other organism	GO:0098542	197	0.551	Mouse
immune effector process	GO:0002252	321	0.399	Mouse
cellular response to lipopolysaccharide	GO:0071222	77	0.146	Mouse
immune response regulating signaling pathway	GO:0002764	125	0.140	Mouse
activation of immune response	GO:0002253	138	0.132	Mouse
regulation of cell activation	GO:0050865	289	0.129	Mouse
regulation of innate immune response	GO:0045088	91	0.121	Mouse
regulation of hydrolase activity	GO:0051336	246	0.119
reactive oxygen species biosynthetic process	GO:1903409	8	0.118
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.110	Mouse
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.103	Mouse
cellular response to lipid	GO:0071396	145	0.102	Mouse
regulation of defense response	GO:0031347	233	0.096	Mouse
immune response activating signal transduction	GO:0002757	116	0.093	Mouse
positive regulation of innate immune response	GO:0045089	80	0.090	Mouse
membrane organization	GO:0061024	245	0.084
cellular response to biotic stimulus	GO:0071216	92	0.080	Human Mouse
positive regulation of cytokine production	GO:0001819	174	0.079
purine containing compound metabolic process	GO:0072521	311	0.077
leukocyte activation involved in immune response	GO:0002366	126	0.076	Mouse
regulation of secretion	GO:0051046	274	0.073	Mouse
lymphocyte mediated immunity	GO:0002449	139	0.071
negative regulation of cellular protein metabolic process	GO:0032269	247	0.070
purine nucleoside metabolic process	GO:0042278	241	0.068
nucleobase containing small molecule metabolic process	GO:0055086	352	0.068
response to molecule of bacterial origin	GO:0002237	143	0.067	Human Mouse
activation of innate immune response	GO:0002218	56	0.065	Mouse
response to molecule of fungal origin	GO:0002238	4	0.064	Mouse
lymphocyte proliferation	GO:0046651	164	0.063	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.062
regulation of cellular ketone metabolic process	GO:0010565	66	0.060
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.060
regulation of secretion by cell	GO:1903530	249	0.058	Mouse
t cell activation	GO:0042110	289	0.058
cation transport	GO:0006812	399	0.057
mapk cascade	GO:0000165	281	0.055	Mouse
cellular amine metabolic process	GO:0044106	44	0.055
multicellular organismal homeostasis	GO:0048871	164	0.055	Mouse
leukocyte mediated immunity	GO:0002443	174	0.054
cellular nitrogen compound catabolic process	GO:0044270	280	0.054
purine ribonucleoside catabolic process	GO:0046130	205	0.053
positive regulation of interferon alpha production	GO:0032727	4	0.053	Mouse
ribonucleoside metabolic process	GO:0009119	245	0.052
regulation of protein transport	GO:0051223	163	0.052	Mouse
glycosyl compound catabolic process	GO:1901658	206	0.052
aromatic compound catabolic process	GO:0019439	286	0.052
regulation of cellular catabolic process	GO:0031329	242	0.051
cellular chemical homeostasis	GO:0055082	215	0.051
guanosine containing compound catabolic process	GO:1901069	144	0.050
cellular homeostasis	GO:0019725	240	0.050
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.050
b cell activation	GO:0042113	161	0.049	Mouse
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.049
positive regulation of secretion by cell	GO:1903532	114	0.049	Mouse
pattern recognition receptor signaling pathway	GO:0002221	47	0.049	Mouse
cellular response to cytokine stimulus	GO:0071345	189	0.048
regulation of leukocyte proliferation	GO:0070663	121	0.048	Mouse
regulation of mapk cascade	GO:0043408	248	0.048	Mouse
cell activation involved in immune response	GO:0002263	126	0.047	Mouse
negative regulation of cellular amine metabolic process	GO:0033239	1	0.047
adaptive immune response	GO:0002250	155	0.047
glycosyl compound metabolic process	GO:1901657	246	0.046
defense response to virus	GO:0051607	68	0.046
cell surface pattern recognition receptor signaling pathway	GO:0002752	2	0.046	Mouse
leukocyte differentiation	GO:0002521	342	0.046
regulation of cell migration	GO:0030334	219	0.046	Mouse
nucleoside phosphate metabolic process	GO:0006753	338	0.046
carbohydrate derivative catabolic process	GO:1901136	231	0.046
cellular response to peptidoglycan	GO:0071224	4	0.046	Mouse
sequestering of calcium ion	GO:0051208	18	0.045
ribonucleoside catabolic process	GO:0042454	206	0.045
cellular metal ion homeostasis	GO:0006875	151	0.045
cytokine production	GO:0001816	319	0.045
lymphocyte activation involved in immune response	GO:0002285	93	0.045	Mouse
nucleoside metabolic process	GO:0009116	246	0.045
regulation of establishment of protein localization	GO:0070201	181	0.044	Mouse
heterocycle catabolic process	GO:0046700	280	0.044
organic cyclic compound catabolic process	GO:1901361	295	0.044
purine ribonucleotide metabolic process	GO:0009150	290	0.043
hematopoietic progenitor cell differentiation	GO:0002244	143	0.043
negative regulation of phosphorus metabolic process	GO:0010563	184	0.043	Mouse
organonitrogen compound catabolic process	GO:1901565	264	0.043
defense response to bacterium	GO:0042742	119	0.042	Mouse
negative regulation of molecular function	GO:0044092	258	0.042
ribonucleotide catabolic process	GO:0009261	208	0.042
negative regulation of protein metabolic process	GO:0051248	282	0.041
positive regulation of programmed cell death	GO:0043068	218	0.041
amine metabolic process	GO:0009308	45	0.041
rho protein signal transduction	GO:0007266	32	0.040
b cell proliferation	GO:0042100	53	0.040	Mouse
cellular response to molecule of bacterial origin	GO:0071219	83	0.040	Human Mouse
leukocyte proliferation	GO:0070661	172	0.039	Mouse
intestinal epithelial structure maintenance	GO:0060729	4	0.039	Mouse
nucleotide metabolic process	GO:0009117	332	0.038
nucleoside triphosphate metabolic process	GO:0009141	230	0.037
nucleoside catabolic process	GO:0009164	206	0.037
regulation of interferon beta biosynthetic process	GO:0045357	4	0.037	Mouse
response to lipopolysaccharide	GO:0032496	128	0.037	Mouse
negative regulation of immune system process	GO:0002683	209	0.037
purine nucleotide metabolic process	GO:0006163	302	0.037
purine ribonucleoside metabolic process	GO:0046128	241	0.036
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.036
nucleotide catabolic process	GO:0009166	217	0.036
purine ribonucleotide catabolic process	GO:0009154	208	0.036
regulation of protein secretion	GO:0050708	82	0.036	Mouse
negative regulation of phosphorylation	GO:0042326	166	0.036	Mouse
regulation of body fluid levels	GO:0050878	162	0.036	Mouse
nucleoside phosphate catabolic process	GO:1901292	222	0.036
cytoplasmic transport	GO:0016482	234	0.035
positive regulation of secretion	GO:0051047	130	0.035	Mouse
sequestering of metal ion	GO:0051238	19	0.035
response to organic cyclic compound	GO:0014070	198	0.035
detection of bacterium	GO:0016045	7	0.035	Human
regulation of inflammatory response	GO:0050727	147	0.035	Mouse
cellular ion homeostasis	GO:0006873	165	0.035
regulation of cellular component biogenesis	GO:0044087	181	0.034
regulation of protein localization	GO:0032880	231	0.034	Mouse
b cell activation involved in immune response	GO:0002312	50	0.034	Mouse
gtp catabolic process	GO:0006184	143	0.034
regulation of lymphocyte activation	GO:0051249	240	0.033	Mouse
regulation of cytokine production	GO:0001817	266	0.033
protein maturation	GO:0051604	176	0.033
purine nucleoside catabolic process	GO:0006152	205	0.033
regulation of organelle organization	GO:0033043	289	0.032
cellular ketone metabolic process	GO:0042180	84	0.032
innate immune response	GO:0045087	157	0.032	Mouse
reactive nitrogen species metabolic process	GO:2001057	0	0.032
protein processing	GO:0016485	163	0.032
regulation of ion transport	GO:0043269	215	0.032
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.032
regulation of lymphocyte proliferation	GO:0050670	117	0.032	Mouse
detection of stimulus	GO:0051606	84	0.032	Human
positive regulation of defense response	GO:0031349	124	0.032	Mouse
tumor necrosis factor superfamily cytokine production	GO:0071706	51	0.031
regulation of leukocyte mediated immunity	GO:0002703	104	0.031
positive regulation of immune effector process	GO:0002699	107	0.031	Mouse
positive regulation of gtp catabolic process	GO:0033126	85	0.031
myeloid cell differentiation	GO:0030099	233	0.031
cellular calcium ion homeostasis	GO:0006874	119	0.030
cytokine secretion	GO:0050663	72	0.030	Mouse
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.030
negative regulation of hydrolase activity	GO:0051346	71	0.030
ribonucleotide metabolic process	GO:0009259	291	0.030
erk1 and erk2 cascade	GO:0070371	77	0.030	Mouse
g protein coupled receptor signaling pathway	GO:0007186	243	0.029
regulation of proteolysis	GO:0030162	164	0.029
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.029
reactive oxygen species metabolic process	GO:0072593	84	0.029
organophosphate catabolic process	GO:0046434	232	0.028
anatomical structure homeostasis	GO:0060249	145	0.028	Mouse
ribose phosphate metabolic process	GO:0019693	291	0.028
regulation of cellular amino acid metabolic process	GO:0006521	5	0.028
regulation of nucleotide metabolic process	GO:0006140	169	0.028
divalent inorganic cation transport	GO:0072511	178	0.028
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.027
t cell proliferation	GO:0042098	120	0.027
purine containing compound catabolic process	GO:0072523	213	0.027
response to organonitrogen compound	GO:0010243	246	0.027	Mouse
metal ion homeostasis	GO:0055065	189	0.027
calcium ion transport	GO:0006816	159	0.027
regulation of b cell activation	GO:0050864	81	0.027	Mouse
regulation of cellular amine metabolic process	GO:0033238	20	0.027
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.026
gtp metabolic process	GO:0046039	144	0.026
cell type specific apoptotic process	GO:0097285	268	0.026
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.026
regulation of protein complex assembly	GO:0043254	83	0.026
positive regulation of hydrolase activity	GO:0051345	148	0.026
positive regulation of cellular amine metabolic process	GO:0033240	5	0.026
maintenance of location	GO:0051235	89	0.025
positive regulation of cell motility	GO:2000147	116	0.025	Mouse
myeloid leukocyte differentiation	GO:0002573	119	0.025
cytosolic calcium ion homeostasis	GO:0051480	70	0.025
calcium ion homeostasis	GO:0055074	127	0.025
regulation of protein serine threonine kinase activity	GO:0071900	157	0.025	Mouse
detection of biotic stimulus	GO:0009595	10	0.025	Human
regulation of ion homeostasis	GO:2000021	64	0.024
homeostasis of number of cells	GO:0048872	210	0.024
sensory perception	GO:0007600	245	0.024
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.024
inflammatory response	GO:0006954	244	0.024	Mouse
negative regulation of protein modification process	GO:0031400	163	0.024
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.024
negative regulation of phosphate metabolic process	GO:0045936	184	0.024	Mouse
ras protein signal transduction	GO:0007265	77	0.024
cell adhesion	GO:0007155	329	0.024
guanosine containing compound metabolic process	GO:1901068	144	0.024
divalent metal ion transport	GO:0070838	172	0.023
cation homeostasis	GO:0055080	212	0.023
transmembrane transport	GO:0055085	412	0.023
cation transmembrane transport	GO:0098655	266	0.023
ossification	GO:0001503	216	0.022
regulation of cell adhesion	GO:0030155	154	0.022
positive regulation of gtpase activity	GO:0043547	85	0.022
organonitrogen compound biosynthetic process	GO:1901566	192	0.022
carbohydrate derivative biosynthetic process	GO:1901137	183	0.022
regulation of cellular response to stress	GO:0080135	159	0.022	Mouse
regulation of peptidase activity	GO:0052547	96	0.022
protein modification by small protein conjugation or removal	GO:0070647	207	0.022
muscle cell differentiation	GO:0042692	261	0.022
posttranscriptional regulation of gene expression	GO:0010608	155	0.022
membrane fusion	GO:0061025	38	0.022
pyroptosis	GO:0070269	8	0.021
divalent inorganic cation homeostasis	GO:0072507	138	0.021
inorganic ion transmembrane transport	GO:0098660	234	0.021
regulation of multi organism process	GO:0043900	111	0.021	Mouse
regulation of t cell activation	GO:0050863	170	0.021
positive regulation of protein secretion	GO:0050714	52	0.021	Mouse
regulation of membrane potential	GO:0042391	192	0.021
regulation of nucleotide catabolic process	GO:0030811	122	0.020
regulation of purine nucleotide metabolic process	GO:1900542	169	0.020
leukocyte migration	GO:0050900	124	0.020	Mouse
regulation of response to biotic stimulus	GO:0002831	38	0.020	Mouse
regulation of anatomical structure size	GO:0090066	178	0.020
negative regulation of protein processing	GO:0010955	79	0.020
apoptotic signaling pathway	GO:0097190	306	0.020
positive regulation of erk1 and erk2 cascade	GO:0070374	47	0.020	Mouse
regulation of nucleoside metabolic process	GO:0009118	130	0.020
protein ubiquitination	GO:0016567	171	0.020
cellular response to growth factor stimulus	GO:0071363	197	0.020
positive regulation of protein transport	GO:0051222	93	0.020	Mouse
purinergic nucleotide receptor signaling pathway	GO:0035590	3	0.020
positive regulation of cytokine secretion	GO:0050715	41	0.020	Mouse
nucleoside triphosphate catabolic process	GO:0009143	205	0.020
protein modification by small protein conjugation	GO:0032446	187	0.019
ion transmembrane transport	GO:0034220	361	0.019
i kappab kinase nf kappab signaling	GO:0007249	85	0.019	Mouse
regulation of erk1 and erk2 cascade	GO:0070372	71	0.019	Mouse
negative regulation of cell proliferation	GO:0008285	296	0.019
stem cell differentiation	GO:0048863	268	0.019
defense response to gram positive bacterium	GO:0050830	50	0.019	Mouse
endocytosis	GO:0006897	168	0.019
purine nucleotide catabolic process	GO:0006195	211	0.019
positive regulation of mapk cascade	GO:0043410	170	0.019	Mouse
protein catabolic process	GO:0030163	221	0.019
positive regulation of nucleotide catabolic process	GO:0030813	88	0.019
neuron apoptotic process	GO:0051402	142	0.019
actin cytoskeleton organization	GO:0030036	220	0.019
transmission of nerve impulse	GO:0019226	76	0.019
negative regulation of cellular component organization	GO:0051129	194	0.019
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.018
spermatogenesis	GO:0007283	284	0.018
oxidation reduction process	GO:0055114	342	0.018
intracellular receptor signaling pathway	GO:0030522	74	0.018	Mouse
inorganic cation transmembrane transport	GO:0098662	207	0.018
positive regulation of cytosolic calcium ion concentration	GO:0007204	65	0.018
regulation of lymphocyte mediated immunity	GO:0002706	84	0.018
interferon gamma production	GO:0032609	67	0.018	Mouse
regulation of actin filament based process	GO:0032970	99	0.018
gland development	GO:0048732	330	0.018
regulation of endopeptidase activity	GO:0052548	89	0.018
regulation of interleukin 18 production	GO:0032661	3	0.018	Mouse
regulation of ossification	GO:0030278	112	0.018
positive regulation of protein modification process	GO:0031401	299	0.018	Mouse
macromolecule catabolic process	GO:0009057	281	0.018
dna metabolic process	GO:0006259	303	0.018
positive regulation of cell development	GO:0010720	237	0.018
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.018
tissue homeostasis	GO:0001894	115	0.018	Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.018
regulation of neuron differentiation	GO:0045664	281	0.018
regulation of neuron death	GO:1901214	134	0.018
response to radiation	GO:0009314	165	0.017
response to growth factor	GO:0070848	198	0.017
regulation of vesicle mediated transport	GO:0060627	139	0.017
release of sequestered calcium ion into cytosol	GO:0051209	42	0.017
epithelial tube morphogenesis	GO:0060562	303	0.017
protein secretion	GO:0009306	111	0.017	Mouse
positive regulation of cell activation	GO:0050867	158	0.017	Mouse
negative regulation of cytokine production	GO:0001818	84	0.017	Mouse
cell killing	GO:0001906	67	0.017
action potential	GO:0001508	78	0.017
t cell differentiation	GO:0030217	174	0.017
regulation of protein processing	GO:0070613	96	0.017
regulation of system process	GO:0044057	200	0.017
negative regulation of protein maturation	GO:1903318	79	0.017
vesicle organization	GO:0016050	60	0.017
digestive system development	GO:0055123	200	0.017
small gtpase mediated signal transduction	GO:0007264	97	0.017
endomembrane system organization	GO:0010256	147	0.017
regulation of cell projection organization	GO:0031344	206	0.017
antimicrobial peptide biosynthetic process	GO:0002777	2	0.017
regulation of antimicrobial peptide biosynthetic process	GO:0002805	1	0.017
digestion	GO:0007586	40	0.016	Mouse
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.016
peptide transport	GO:0015833	133	0.016
negative regulation of multi organism process	GO:0043901	68	0.016	Mouse
organic hydroxy compound metabolic process	GO:1901615	203	0.016
multicellular organismal signaling	GO:0035637	91	0.016
morphogenesis of embryonic epithelium	GO:0016331	159	0.016
innate immune response activating cell surface receptor signaling pathway	GO:0002220	4	0.016	Mouse
toll like receptor signaling pathway	GO:0002224	38	0.016	Mouse
positive regulation of purine nucleotide catabolic process	GO:0033123	88	0.016
stress activated protein kinase signaling cascade	GO:0031098	81	0.016	Mouse
regulation of protein maturation	GO:1903317	96	0.016
regulation of cell motility	GO:2000145	236	0.016	Mouse
regulation of intracellular transport	GO:0032386	159	0.016
positive regulation of nucleotide metabolic process	GO:0045981	114	0.016
regulation of purine nucleotide catabolic process	GO:0033121	122	0.016
intrinsic apoptotic signaling pathway	GO:0097193	132	0.016
regulation of b cell proliferation	GO:0030888	39	0.016	Mouse
neuronal action potential	GO:0019228	54	0.016
regulation of cytokine biosynthetic process	GO:0042035	59	0.016
regulation of jnk cascade	GO:0046328	62	0.016	Mouse
neuron death	GO:0070997	154	0.016
regulation of metal ion transport	GO:0010959	106	0.016
positive regulation of cellular catabolic process	GO:0031331	148	0.016
positive regulation of antimicrobial peptide production	GO:0002225	1	0.016
detection of other organism	GO:0098543	8	0.015	Human
nitrogen compound transport	GO:0071705	271	0.015
antigen receptor mediated signaling pathway	GO:0050851	64	0.015
transepithelial chloride transport	GO:0030321	4	0.015
glycoprotein metabolic process	GO:0009100	116	0.015
cellular response to abiotic stimulus	GO:0071214	56	0.015
toll like receptor 7 signaling pathway	GO:0034154	4	0.015
regulation of interferon beta production	GO:0032648	13	0.015	Mouse
organophosphate biosynthetic process	GO:0090407	122	0.015
regulation of ras protein signal transduction	GO:0046578	114	0.015
skin development	GO:0043588	220	0.015
positive regulation of cell death	GO:0010942	224	0.015
carbohydrate homeostasis	GO:0033500	128	0.015
response to drug	GO:0042493	75	0.015	Mouse
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.015
regulation of transferase activity	GO:0051338	263	0.015	Mouse
leukocyte homeostasis	GO:0001776	79	0.015
cellular lipid metabolic process	GO:0044255	323	0.015
positive regulation of cellular component biogenesis	GO:0044089	94	0.015
alpha beta t cell activation	GO:0046631	91	0.015
axonogenesis	GO:0007409	274	0.015
peptidyl amino acid modification	GO:0018193	336	0.015
regulation of leukocyte differentiation	GO:1902105	159	0.015
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.015
regulation of cytoskeleton organization	GO:0051493	122	0.015
negative regulation of cell activation	GO:0050866	111	0.015
cellular response to interferon beta	GO:0035458	21	0.014
regulation of cell cycle process	GO:0010564	160	0.014
skeletal system development	GO:0001501	356	0.014
negative regulation of ripoptosome assembly involved in necroptotic process	GO:1902443	3	0.014
interferon beta biosynthetic process	GO:0045350	4	0.014	Mouse
regulation of cell cycle	GO:0051726	281	0.014
protein localization to membrane	GO:0072657	108	0.014
regulation of interleukin 1 alpha production	GO:0032650	4	0.014
glucose homeostasis	GO:0042593	128	0.014
regulation of osteoblast differentiation	GO:0045667	67	0.014
calcium ion transport into cytosol	GO:0060402	48	0.014
negative regulation of proteolysis	GO:0045861	74	0.014
modification by symbiont of host morphology or physiology	GO:0044003	4	0.014	Mouse
tube formation	GO:0035148	140	0.014
cellular response to dna damage stimulus	GO:0006974	207	0.014
positive regulation by symbiont of defense related host nitric oxide production	GO:0052347	1	0.014	Mouse
cellular response to hormone stimulus	GO:0032870	150	0.014
positive regulation by symbiont of host defense response	GO:0052509	1	0.014	Mouse
microtubule based process	GO:0007017	236	0.014
actin filament polymerization	GO:0030041	44	0.014
positive regulation of apoptotic process	GO:0043065	217	0.014
regulation of tumor necrosis factor production	GO:0032680	49	0.014
dephosphorylation	GO:0016311	129	0.014
chemotaxis	GO:0006935	247	0.014
cellular response to organonitrogen compound	GO:0071417	145	0.014	Mouse
regulation of map kinase activity	GO:0043405	120	0.014	Mouse
innate immune response activating signal transduction	GO:0002758	50	0.014	Mouse
response to bacterial lipopeptide	GO:0070339	3	0.014	Human Mouse
nitric oxide biosynthetic process	GO:0006809	25	0.014	Mouse
regulation of actin cytoskeleton organization	GO:0032956	84	0.014
compound eye development	GO:0048749	1	0.014
positive regulation of leukocyte proliferation	GO:0070665	73	0.014	Mouse
nucleocytoplasmic transport	GO:0006913	139	0.014
thrombin receptor signaling pathway	GO:0070493	2	0.014
regulation of homeostatic process	GO:0032844	182	0.013
regulation of t cell proliferation	GO:0042129	92	0.013
regulation of cytoplasmic transport	GO:1903649	112	0.013
actin polymerization or depolymerization	GO:0008154	54	0.013
cytokine metabolic process	GO:0042107	71	0.013
negative regulation of intracellular signal transduction	GO:1902532	167	0.013	Mouse
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.013
positive regulation of kinase activity	GO:0033674	155	0.013	Mouse
digestive tract development	GO:0048565	190	0.013
negative regulation of t cell activation	GO:0050868	65	0.013
regulation of protein catabolic process	GO:0042176	108	0.013
regulation of cytokine secretion	GO:0050707	61	0.013	Mouse
alpha beta t cell differentiation	GO:0046632	69	0.013
antimicrobial peptide production	GO:0002775	2	0.013
anion transport	GO:0006820	177	0.013
regulation of intracellular protein transport	GO:0033157	82	0.013
negative regulation of protein phosphorylation	GO:0001933	126	0.013
regulation of natural killer cell activation	GO:0032814	22	0.013
organic hydroxy compound transport	GO:0015850	93	0.013
forebrain development	GO:0030900	302	0.013
positive regulation of lymphocyte activation	GO:0051251	140	0.013	Mouse
negative regulation of chromatin silencing	GO:0031936	1	0.013
blood circulation	GO:0008015	195	0.013
jnk cascade	GO:0007254	72	0.013	Mouse
interleukin 18 production	GO:0032621	4	0.013	Mouse
negative regulation of growth	GO:0045926	99	0.013	Mouse
regulation of interleukin 1 beta production	GO:0032651	25	0.013
carbohydrate metabolic process	GO:0005975	230	0.012
negative regulation of mapk cascade	GO:0043409	65	0.012	Mouse
ear development	GO:0043583	200	0.012
negative regulation of b cell receptor signaling pathway	GO:0050859	4	0.012
inorganic anion transport	GO:0015698	43	0.012
vesicle fusion	GO:0006906	16	0.012
neural tube formation	GO:0001841	108	0.012
positive regulation of interferon gamma production	GO:0032729	39	0.012	Mouse
positive regulation of stress activated mapk cascade	GO:0032874	48	0.012	Mouse
response to host defenses	GO:0052200	3	0.012	Mouse
male gamete generation	GO:0048232	285	0.012
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.012
regulation of gtp catabolic process	GO:0033124	113	0.012
positive regulation of cell migration	GO:0030335	109	0.012	Mouse
intracellular protein transport	GO:0006886	204	0.012
positive regulation of antimicrobial peptide biosynthetic process	GO:0002807	1	0.012
glycoprotein biosynthetic process	GO:0009101	89	0.012
negative regulation of lymphocyte activation	GO:0051250	91	0.012
modulation by symbiont of host immune response	GO:0052553	1	0.012	Mouse
production of molecular mediator of immune response	GO:0002440	103	0.012	Mouse
type i interferon production	GO:0032606	29	0.012	Mouse
interferon beta production	GO:0032608	16	0.012	Mouse
mitotic cell cycle	GO:0000278	195	0.012
negative regulation of gene silencing	GO:0060969	2	0.012
regulation of type i interferon production	GO:0032479	22	0.012	Mouse
regulation of hormone levels	GO:0010817	211	0.012
regulation of antimicrobial peptide production	GO:0002784	1	0.012
interspecies interaction between organisms	GO:0044419	83	0.012	Mouse
leukocyte mediated cytotoxicity	GO:0001909	62	0.012
negative regulation of peptidase activity	GO:0010466	46	0.012
organelle assembly	GO:0070925	177	0.012
epithelial structure maintenance	GO:0010669	9	0.012	Mouse
positive regulation of protein kinase activity	GO:0045860	144	0.011	Mouse
regulation of tumor necrosis factor superfamily cytokine production	GO:1903555	50	0.011
cd4 positive alpha beta t cell activation	GO:0035710	45	0.011
dna modification	GO:0006304	50	0.011
blood coagulation	GO:0007596	76	0.011	Mouse
retrograde transport endosome to golgi	GO:0042147	2	0.011
renal system development	GO:0072001	225	0.011
kidney development	GO:0001822	213	0.011
monocarboxylic acid metabolic process	GO:0032787	191	0.011
muscle system process	GO:0003012	141	0.011
positive regulation of cytokine biosynthetic process	GO:0042108	40	0.011
dna recombination	GO:0006310	92	0.011
response to acid chemical	GO:0001101	111	0.011
positive regulation of production of molecular mediator of immune response	GO:0002702	45	0.011	Mouse
protein localization to organelle	GO:0033365	185	0.011
regulation of cell killing	GO:0031341	40	0.011
induction by organism of immune response of other organism involved in symbiotic interaction	GO:0052558	1	0.011	Mouse
regulation of blood circulation	GO:1903522	93	0.011
regulation of antimicrobial humoral response	GO:0002759	3	0.011
negative regulation of myeloid cell differentiation	GO:0045638	38	0.011
positive regulation of nucleoside metabolic process	GO:0045979	91	0.011
morphogenesis of a branching structure	GO:0001763	203	0.011
immunoglobulin production	GO:0002377	73	0.011
regulation of stress activated mapk cascade	GO:0032872	69	0.011	Mouse
peptide metabolic process	GO:0006518	46	0.011
negative regulation of organelle organization	GO:0010639	90	0.011
positive regulation of t cell extravasation	GO:2000409	2	0.011
nucleotide biosynthetic process	GO:0009165	78	0.011
regulation of renin secretion into blood stream	GO:1900133	4	0.011
developmental maturation	GO:0021700	193	0.011
stem cell development	GO:0048864	219	0.011
regulation of response to wounding	GO:1903034	189	0.011	Mouse
regulation of interleukin 10 production	GO:0032653	21	0.011	Mouse
positive regulation of nervous system development	GO:0051962	221	0.011
regulation of apoptotic signaling pathway	GO:2001233	197	0.011
cognition	GO:0050890	149	0.011
interleukin 8 production	GO:0032637	4	0.011
positive regulation of coagulation	GO:0050820	13	0.011	Mouse
respiratory tube development	GO:0030323	167	0.010
cellular protein complex assembly	GO:0043623	116	0.010
epithelial tube formation	GO:0072175	130	0.010
circulatory system process	GO:0003013	197	0.010
positive regulation of leukocyte mediated immunity	GO:0002705	70	0.010
peptide hormone secretion	GO:0030072	109	0.010
lipid biosynthetic process	GO:0008610	179	0.010
cytokine biosynthetic process	GO:0042089	68	0.010
positive regulation of endocytosis	GO:0045807	42	0.010
cytosolic calcium ion transport	GO:0060401	48	0.010
organelle localization	GO:0051640	179	0.010
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.010
placenta development	GO:0001890	140	0.010
cellular macromolecule catabolic process	GO:0044265	206	0.010
positive regulation of organelle organization	GO:0010638	128	0.010
morphogenesis of a branching epithelium	GO:0061138	193	0.010
alcohol metabolic process	GO:0006066	116	0.010
plasma membrane organization	GO:0007009	90	0.010
detection of external biotic stimulus	GO:0098581	9	0.010	Human
spermatid differentiation	GO:0048515	115	0.010
lateral inhibition	GO:0046331	1	0.010
chloride transport	GO:0006821	32	0.010
chromatin modification	GO:0016568	187	0.010
cell fate commitment	GO:0045165	210	0.010
second messenger mediated signaling	GO:0019932	73	0.010
organelle fusion	GO:0048284	28	0.010

Tlr1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.018
musculoskeletal system disease	DOID:17	0.015
disease of anatomical entity	DOID:7	0.015
connective tissue disease	DOID:65	0.015
nervous system disease	DOID:863	0.014

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