Mus musculus

370 known processes

Tlr4

toll-like receptor 4

(Aliases: Rasl2-8,Ran/M1,Lps,Ly87)

Tlr4 biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
interleukin 18 mediated signaling pathwayGO:003565521.000
cellular response to interleukin 18GO:007135131.000
positive regulation of lipopolysaccharide mediated signaling pathwayGO:003166651.000
Mouse
interferon beta biosynthetic processGO:004535041.000
i kappab kinase nf kappab signalingGO:0007249851.000
regulation of interleukin 6 productionGO:0032675551.000
positive regulation of interferon beta biosynthetic processGO:004535931.000
positive regulation of chemokine productionGO:0032722221.000
cellular response to molecule of bacterial originGO:0071219831.000
positive regulation of chemokine biosynthetic processGO:004508061.000
cellular response to biotic stimulusGO:0071216921.000
regulation of defense responseGO:00313472331.000
response to molecule of bacterial originGO:00022371431.000
pattern recognition receptor signaling pathwayGO:0002221471.000
positive regulation of interleukin 6 productionGO:0032755371.000
cellular response to lipopolysaccharideGO:0071222771.000
chemokine biosynthetic processGO:004203381.000
antimicrobial peptide productionGO:000277521.000
cytokine productionGO:00018163191.000
response to lipopolysaccharideGO:00324961281.000
regulation of reactive oxygen species biosynthetic processGO:190342621.000
lipopolysaccharide mediated signaling pathwayGO:0031663251.000
response to interleukin 12GO:007067121.000
negative regulation of inflammatory response to antigenic stimulusGO:0002862101.000
antibacterial peptide productionGO:000277821.000
induction by organism of immune response of other organism involved in symbiotic interactionGO:005255811.000
Mouse
interleukin 23 productionGO:003262721.000
response to molecule of fungal originGO:000223840.999
Mouse
cytokine mediated signaling pathwayGO:00192211150.999
cellular response to lipidGO:00713961450.999
regulation of b cell proliferationGO:0030888390.999
chemokine metabolic processGO:0050755100.999
regulation of cell activationGO:00508652890.999
defense response to other organismGO:00985421970.999
regulation of innate immune responseGO:0045088910.999
positive regulation of tumor necrosis factor superfamily cytokine productionGO:1903557310.999
response to defense related nitric oxide production by other organism involved in symbiotic interactionGO:005255120.998
Mouse
chemokine productionGO:0032602340.998
cytokine biosynthetic processGO:0042089680.998
response to peptidoglycanGO:003249490.998
Mouse
interferon beta productionGO:0032608160.998
regulation of cytokine productionGO:00018172660.998
positive regulation of lymphocyte proliferationGO:0050671700.998
regulation of nucleotide binding oligomerization domain containing 1 signaling pathwayGO:007042830.998
regulation of chemokine biosynthetic processGO:004507380.997
regulation of immune complex clearance by monocytes and macrophagesGO:009026420.997
inflammatory response to woundingGO:009059440.997
regulation of reactive oxygen species metabolic processGO:2000377400.997
positive regulation of b cell activationGO:0050871490.997
positive regulation of interleukin 18 productionGO:003274120.997
Mouse
reactive nitrogen species metabolic processGO:200105700.997
positive regulation of cytokine productionGO:00018191740.996
b cell activationGO:00421131610.996
response to defense related host nitric oxide productionGO:005256520.996
Mouse
immune response regulating signaling pathwayGO:00027641250.996
macrophage activationGO:0042116270.996
Human Rat
response to hostGO:007513630.996
Mouse
positive regulation of defense responseGO:00313491240.995
modulation by symbiont of defense related host nitric oxide productionGO:005216310.995
Mouse
negative regulation of cytokine productionGO:0001818840.995
regulation of lymphocyte activationGO:00512492400.995
negative regulation of t cell proliferationGO:0042130380.995
positive regulation of innate immune responseGO:0045089800.995
interleukin 33 mediated signaling pathwayGO:003817210.994
inflammatory responseGO:00069542440.994
b cell proliferationGO:0042100530.993
response to interleukin 18GO:007067340.993
negative regulation of chemokine biosynthetic processGO:004507920.993
positive regulation of cytokine biosynthetic processGO:0042108400.993
positive regulation of reactive oxygen species biosynthetic processGO:190342820.993
neutrophil apoptotic processGO:000178130.992
production of molecular mediator of immune responseGO:00024401030.992
nucleotide binding oligomerization domain containing signaling pathwayGO:007042360.991
regulation of inflammatory responseGO:00507271470.991
positive regulation of antimicrobial peptide productionGO:000222510.990
regulation of lymphocyte proliferationGO:00506701170.988
regulation of interleukin 18 productionGO:003266130.988
Mouse
negative regulation of necroptotic processGO:006054690.987
interleukin 18 productionGO:003262140.985
Mouse
regulation of mhc class ii biosynthetic processGO:004534670.985
positive regulation of natural killer cell activationGO:0032816150.984
regulation of acute inflammatory responseGO:0002673270.983
positive regulation by symbiont of host immune responseGO:005255610.983
Mouse
leukocyte proliferationGO:00706611720.983
stress activated mapk cascadeGO:0051403800.982
positive regulation of cell activationGO:00508671580.981
reactive oxygen species metabolic processGO:0072593840.981
response to organic cyclic compoundGO:00140701980.980
Rat
regulation of tumor necrosis factor productionGO:0032680490.980
positive regulation of leukocyte proliferationGO:0070665730.980
cellular response to oxidative stressGO:0034599760.979
cellular response to bacterial lipopeptideGO:007122130.979
Mouse
regulation of cytokine biosynthetic processGO:0042035590.978
regulation of leukocyte proliferationGO:00706631210.978
regulation of response to woundingGO:19030341890.978
positive regulation of reactive oxygen species metabolic processGO:2000379110.978
type i interferon productionGO:0032606290.977
cellular response to cytokine stimulusGO:00713451890.977
immune response regulating cell surface receptor signaling pathwayGO:0002768800.975
Mouse
lymphocyte proliferationGO:00466511640.975
regulation of nucleotide binding oligomerization domain containing signaling pathwayGO:007042430.974
positive regulation of type i interferon productionGO:0032481140.972
cytokine metabolic processGO:0042107710.972
regulation of interleukin 1 productionGO:0032652260.972
positive regulation by symbiont of host defense responseGO:005250910.971
Mouse
regulation of establishment of protein localizationGO:00702011810.969
Human Mouse
positive regulation of production of molecular mediator of immune responseGO:0002702450.968
positive regulation of protein secretionGO:0050714520.968
Mouse
antibacterial peptide biosynthetic processGO:000278020.967
modulation by symbiont of host immune responseGO:005255310.966
Mouse
positive regulation of protein transportGO:0051222930.966
Human Mouse
response to host immune responseGO:005257230.960
Mouse
positive regulation of b cell proliferationGO:0030890240.960
defense response to virusGO:0051607680.959
regulation of natural killer cell activationGO:0032814220.957
regulation of cellular amine metabolic processGO:0033238200.956
innate immune responseGO:00450871570.956
positive regulation of interferon beta productionGO:003272880.955
regulation of interleukin 1 beta secretionGO:0050706150.954
myd88 dependent toll like receptor signaling pathwayGO:000275570.953
Mouse
necroptotic processGO:0070266210.952
positive regulation of protein modification processGO:00314012990.950
response to interleukin 1GO:0070555110.949
natural killer cell activationGO:0030101440.948
interleukin 6 productionGO:0032635580.948
positive regulation of nf kappab transcription factor activityGO:0051092300.948
Human Rat
regulation of inflammatory response to antigenic stimulusGO:0002861210.947
positive regulation of nitric oxide biosynthetic processGO:0045429140.947
nitric oxide metabolic processGO:0046209250.947
regulation of nucleotide binding oligomerization domain containing 2 signaling pathwayGO:007043230.945
activation of immune responseGO:00022531380.942
regulation of interleukin 17 productionGO:003266080.938
positive regulation of intracellular transportGO:0032388700.936
Human
regulation of cellular amino acid metabolic processGO:000652150.936
cytoplasmic pattern recognition receptor signaling pathwayGO:0002753100.936
regulation of production of molecular mediator of immune responseGO:0002700650.934
tumor necrosis factor productionGO:0032640500.934
immune response activating signal transductionGO:00027571160.933
activation of innate immune responseGO:0002218560.932
nitric oxide biosynthetic processGO:0006809250.931
positive regulation of cellular amino acid metabolic processGO:004576430.930
apoptotic signaling pathwayGO:00971903060.926
cellular response to bacterial lipoproteinGO:007122030.921
Mouse
response to bacterial lipoproteinGO:003249340.921
Mouse
positive regulation of jnk cascadeGO:0046330460.920
positive regulation of tumor necrosis factor productionGO:0032760300.918
negative regulation of growth of symbiont involved in interaction with hostGO:0044146190.918
Mouse
interleukin 6 biosynthetic processGO:0042226120.918
Mouse
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237450.916
adaptive immune responseGO:00022501550.915
Rat
regulation of necroptotic processGO:0060544100.915
regulation of tumor necrosis factor superfamily cytokine productionGO:1903555500.913
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280360.908
negative regulation of phosphorus metabolic processGO:00105631840.908
negative regulation of necrotic cell deathGO:0060547110.907
regulation of monocyte extravasationGO:200043720.906
positive regulation of nucleotide binding oligomerization domain containing 1 signaling pathwayGO:007043010.902
growth of symbiont in hostGO:0044117230.902
Mouse
tumor necrosis factor superfamily cytokine productionGO:0071706510.901
leukocyte activation involved in immune responseGO:00023661260.900
regulation of peptidyl tyrosine phosphorylationGO:0050730930.900
Rat
immunoglobulin mediated immune responseGO:0016064690.899
Rat
growth involved in symbiotic interactionGO:0044110230.897
Mouse
positive regulation of interleukin 1 productionGO:0032732170.896
pyroptosisGO:007026980.894
regulation of secretion by cellGO:19035302490.894
Mouse
positive regulation of inflammatory responseGO:0050729470.893
Rat
defense response to gram negative bacteriumGO:0050829280.891
amine metabolic processGO:0009308450.889
interspecies interaction between organismsGO:0044419830.888
Mouse
positive regulation of cytokine secretionGO:0050715410.888
Mouse
regulation of cellular response to stressGO:00801351590.887
response to low density lipoprotein particleGO:005509820.883
regulation of chronic inflammatory response to antigenic stimulusGO:000287430.881
regulation of growth of symbiont in hostGO:0044126190.879
Mouse
regulation of membrane potentialGO:00423911920.875
regulation of cytokine production involved in immune responseGO:0002718260.872
wound healing involved in inflammatory responseGO:000224640.871
regulation of interleukin 6 biosynthetic processGO:0045408110.871
Mouse
peptidyl amino acid modificationGO:00181933360.871
Rat
type i interferon biosynthetic processGO:004535190.868
positive regulation of t cell proliferationGO:0042102520.867
regulation of nitric oxide biosynthetic processGO:0045428180.866
negative regulation of interleukin 6 productionGO:0032715170.865
regulation of macrophage cytokine productionGO:001093580.865
negative regulation of reactive oxygen species biosynthetic processGO:190342700.862
regulation of interferon gamma productionGO:0032649570.861
regulation of b cell activationGO:0050864810.860
regulation of sequence specific dna binding transcription factor activityGO:00510901060.856
Human Rat
regulation of protein localizationGO:00328802310.854
Human Mouse
positive regulation of secretionGO:00510471300.851
Mouse
positive regulation by organism of defense related nitric oxide production in other organism involved in symbiotic interactionGO:005234510.849
Mouse
response to host defensesGO:005220030.844
Mouse
coagulationGO:0050817780.843
cellular amine metabolic processGO:0044106440.837
t cell activationGO:00421102890.835
cellular response to lipoteichoic acidGO:007122360.831
antibacterial humoral responseGO:001973180.827
extrinsic apoptotic signaling pathway via death domain receptorsGO:0008625340.822
induction by symbiont of host immune responseGO:005255910.819
Mouse
eosinophil activation involved in immune responseGO:000227810.817
positive regulation of nucleotide binding oligomerization domain containing 2 signaling pathwayGO:007043420.815
positive regulation of protein phosphorylationGO:00019342420.815
antibacterial peptide secretionGO:000277910.813
leukocyte apoptotic processGO:0071887710.811
positive regulation of interferon alpha productionGO:003272740.808
fever generationGO:000166070.808
interferon gamma productionGO:0032609670.806
innate immune response activating cell surface receptor signaling pathwayGO:000222040.803
Mouse
induction by organism of defense response of other organism involved in symbiotic interactionGO:005225110.800
Mouse
negative regulation of tumor necrosis factor productionGO:0032720170.799
negative regulation of phosphorylationGO:00423261660.797
defense response to gram positive bacteriumGO:0050830500.794
Mouse
nucleotide binding oligomerization domain containing 2 signaling pathwayGO:007043160.788
detection of external biotic stimulusGO:009858190.785
Human
protein secretionGO:00093061110.783
Mouse
cell surface pattern recognition receptor signaling pathwayGO:000275220.780
Mouse
acute inflammatory responseGO:0002526410.778
hepatocyte apoptotic processGO:0097284110.776
positive regulation of nitric oxide synthase biosynthetic processGO:005177060.773
positive regulation of response to woundingGO:1903036660.769
regulation of protein secretionGO:0050708820.767
Mouse
response to bacterial lipopeptideGO:007033930.763
Mouse
protein modification by small protein conjugation or removalGO:00706472070.761
negative regulation of chemokine productionGO:003268240.756
regulation of leukocyte apoptotic processGO:2000106560.747
glial cell apoptotic processGO:003434930.746
humoral immune responseGO:0006959570.743
intrinsic apoptotic signaling pathwayGO:00971931320.743
regulation of cysteine type endopeptidase activityGO:2000116650.739
negative regulation of lymphocyte proliferationGO:0050672450.735
regulation of antibacterial peptide biosynthetic processGO:000280810.730
positive regulation of cd8 positive alpha beta t cell extravasationGO:200045120.730
regulation of protein transportGO:00512231630.728
Human Mouse
cellular amino acid metabolic processGO:00065201030.726
modulation by organism of defense related nitric oxide production in other organism involved in symbiotic interactionGO:005230210.722
Mouse
regulation of proteolysisGO:00301621640.721
regulation of peptidase activityGO:0052547960.720
regulation of interferon beta biosynthetic processGO:004535740.714
negative regulation of immune system processGO:00026832090.711
negative regulation of protein metabolic processGO:00512482820.710
cellular response to estrogen stimulusGO:0071391120.708
positive regulation of peptidase activityGO:0010952490.701
positive regulation of chronic inflammatory responseGO:000267840.701
immune effector processGO:00022523210.700
cellular amide metabolic processGO:0043603580.698
innate immune response activating signal transductionGO:0002758500.695
homeostasis of number of cellsGO:00488722100.694
positive regulation of sequence specific dna binding transcription factor activityGO:0051091680.690
Human Rat
regulation of cytokine secretionGO:0050707610.688
Mouse
peptide transportGO:00158331330.687
Human
multicellular organismal homeostasisGO:00488711640.687
positive regulation of map kinase activityGO:0043406840.684
myeloid leukocyte cytokine productionGO:0061082120.680
regulation of protein serine threonine kinase activityGO:00719001570.678
response to oxidative stressGO:00069791230.676
Rat
positive regulation of proteolysisGO:0045862850.675
regulation of secretionGO:00510462740.675
Mouse
tumor necrosis factor mediated signaling pathwayGO:0033209130.674
regulation of protein bindingGO:0043393600.673
nucleotide binding oligomerization domain containing 1 signaling pathwayGO:007042750.670
regulation of apoptotic signaling pathwayGO:20012331970.669
toxin transportGO:1901998380.668
Mouse
regulation of antimicrobial humoral responseGO:000275930.663
nitric oxide production involved in inflammatory responseGO:000253720.662
regulation of dendritic cell chemotaxisGO:200050810.659
regulation of protein ubiquitinationGO:0031396520.659
nuclear importGO:0051170950.659
Human
regulation of interleukin 8 productionGO:003267730.649
Human
interleukin 1 mediated signaling pathwayGO:007049840.647
nitric oxide synthase biosynthetic processGO:005176770.647
positive regulation of cytoplasmic transportGO:1903651400.645
Human
positive regulation of neuron apoptotic processGO:0043525250.644
regulation of type i interferon productionGO:0032479220.642
positive regulation of antimicrobial humoral responseGO:000276020.639
positive regulation of t cell costimulationGO:200052520.638
microglial cell activation involved in immune responseGO:000228210.636
interleukin 1 alpha secretionGO:005070330.636
organic acid transportGO:00158491010.635
negative regulation of molecular functionGO:00440922580.635
lipid localizationGO:00108761260.634
keratinocyte migrationGO:005154630.632
eosinophil degranulationGO:004330810.629
programmed necrotic cell deathGO:0097300280.627
intestinal epithelial structure maintenanceGO:006072940.626
antibiotic transportGO:004289110.625
Mouse
tissue homeostasisGO:00018941150.619
monocyte extravasationGO:003569620.615
mapk cascadeGO:00001652810.614
regulation of necrotic cell deathGO:0010939130.613
protein ubiquitinationGO:00165671710.610
immune complex clearance by monocytes and macrophagesGO:000243620.607
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281620.607
positive regulation of secretion by cellGO:19035321140.605
Mouse
peptidyl serine modificationGO:0018209830.604
regulation of interleukin 1 secretionGO:0050704150.603
positive regulation of cysteine type endopeptidase activityGO:2001056390.602
interleukin 1 productionGO:0032612310.596
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.593
Rat
lipid homeostasisGO:0055088630.592
positive regulation of mhc class ii biosynthetic processGO:004534840.591
modification of morphology or physiology of other organism involved in symbiotic interactionGO:0051817160.591
Mouse
positive regulation of stress activated mapk cascadeGO:0032874480.590
regulation of chemokine secretionGO:009019640.589
regulation of natural killer cell differentiationGO:0032823110.586
modulation by organism of defense response of other organism involved in symbiotic interactionGO:005225510.585
Mouse
negative regulation of cell activationGO:00508661110.585
positive regulation of protein ubiquitinationGO:0031398270.585
regulation of ion transportGO:00432692150.582
positive regulation of kinase activityGO:00336741550.582
neuron deathGO:00709971540.581
cd4 positive alpha beta t cell differentiationGO:0043367410.580
positive regulation of interleukin 1 secretionGO:0050716140.578
toll like receptor signaling pathwayGO:0002224380.577
Mouse Rat
positive regulation of apoptotic signaling pathwayGO:2001235950.576
response to vitamin aGO:003318910.576
positive regulation of multi organism processGO:0043902260.575
Mouse
dna metabolic processGO:00062593030.574
response to inorganic substanceGO:0010035960.570
fatty acid metabolic processGO:00066311210.568
Rat
positive regulation of immune complex clearance by monocytes and macrophagesGO:009026520.567
regulation of rna stabilityGO:0043487260.564
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathwayGO:200126930.564
positive regulation of hemostasisGO:1900048100.563
response to endoplasmic reticulum stressGO:0034976530.561
inflammatory cell apoptotic processGO:0006925110.560
positive regulation of interferon gamma productionGO:0032729390.560
action potentialGO:0001508780.558
positive regulation of antibacterial peptide biosynthetic processGO:000696310.558
positive regulation of myeloid cell differentiationGO:0045639430.557
negative regulation of leukocyte proliferationGO:0070664460.552
immune response activating cell surface receptor signaling pathwayGO:0002429720.550
Mouse
response to organonitrogen compoundGO:00102432460.547
Mouse Rat
regulation of lipopolysaccharide mediated signaling pathwayGO:003166490.547
Mouse
vascular endothelial growth factor productionGO:0010573130.546
epithelial cell proliferationGO:00506731740.544
regulation of apoptotic dna fragmentationGO:190251050.540
interleukin 6 mediated signaling pathwayGO:007010260.540
negative regulation of t cell activationGO:0050868650.535
regulation of chronic inflammatory responseGO:000267670.534
blood vessel morphogenesisGO:00485142850.530
response to oxygen levelsGO:0070482620.528
Rat
anatomical structure homeostasisGO:00602491450.525
regulation of mapk cascadeGO:00434082480.522
positive regulation of immunological synapse formationGO:200052210.522
negative regulation of protein processingGO:0010955790.518
organ or tissue specific immune responseGO:0002251130.515
positive regulation of lymphocyte activationGO:00512511400.511
production of molecular mediator involved in inflammatory responseGO:0002532210.511
epidermal growth factor receptor signaling pathwayGO:0007173280.508
response to alcoholGO:0097305480.506
Rat
regulation of vascular endothelial growth factor productionGO:0010574130.506
positive regulation of protein modification by small protein conjugation or removalGO:1903322300.503
growth of symbiont involved in interaction with hostGO:0044116230.503
Mouse
regulation of bindingGO:00510981110.502
Rat
positive regulation of protein bindingGO:0032092290.501
protein oligomerizationGO:0051259670.499
regulation of cellular ketone metabolic processGO:0010565660.499
response to defenses of other organism involved in symbiotic interactionGO:005217330.497
Mouse
interleukin 17 productionGO:0032620110.494
regulation of protein homodimerization activityGO:004349640.493
neuronal action potentialGO:0019228540.492
positive regulation of mapk cascadeGO:00434101700.491
lymphocyte homeostasisGO:0002260640.489
defense response to bacteriumGO:00427421190.489
response to tumor necrosis factorGO:0034612260.489
regulation of neuron deathGO:19012141340.489
granulocyte chemotaxisGO:0071621390.489
positive regulation of cell developmentGO:00107202370.487
negative regulation of ripoptosome assembly involved in necroptotic processGO:190244330.484
response to glucocorticoidGO:0051384200.482
Rat
negative regulation of phosphate metabolic processGO:00459361840.482
cellular response to organonitrogen compoundGO:00714171450.481
Mouse
cellular ketone metabolic processGO:0042180840.480
necroptotic signaling pathwayGO:009752730.479
cellular response to tumor necrosis factorGO:0071356210.478
regulation of tumor necrosis factor biosynthetic processGO:0042534100.476
Human Mouse
antimicrobial peptide biosynthetic processGO:000277720.476
somatic diversification of immune receptorsGO:0002200530.475
regulation of cytoplasmic transportGO:19036491120.473
Human
regulation of defense response to bacteriumGO:190042430.472
response to dsrnaGO:0043331300.469
macrophage activation involved in immune responseGO:000228170.465
erk1 and erk2 cascadeGO:0070371770.465
response to immune response of other organism involved in symbiotic interactionGO:005256430.465
Mouse
regulation of response to cytokine stimulusGO:0060759230.465
cellular response to interleukin 4GO:0071353210.464
intrinsic apoptotic signaling pathway in response to oxidative stressGO:0008631190.463
negative regulation of macrophage cytokine productionGO:001093610.461
myeloid cell differentiationGO:00300992330.459
positive regulation of hematopoietic stem cell migrationGO:200047310.458
lymphocyte apoptotic processGO:0070227540.457
positive regulation of membrane protein ectodomain proteolysisGO:005104430.452
regulation of interleukin 1 alpha secretionGO:005070530.452
chemokine mediated signaling pathwayGO:0070098170.451
cellular response to abiotic stimulusGO:0071214560.450
Human Rat
positive regulation of apoptotic cell clearanceGO:200042730.447
jnk cascadeGO:0007254720.445
regulation of interleukin 1 beta productionGO:0032651250.438
response to ethanolGO:0045471180.436
Rat
anion transportGO:00068201770.432
negative regulation of hydrolase activityGO:0051346710.431
eosinophil activationGO:004330710.427
b cell homeostasisGO:0001782340.425
release of cytochrome c from mitochondriaGO:0001836230.424
positive regulation of nucleotide binding oligomerization domain containing signaling pathwayGO:007042620.422
regulation of response to oxidative stressGO:1902882190.418
superoxide metabolic processGO:0006801270.416
response to iron ionGO:001003940.416
positive regulation of immunoglobulin productionGO:0002639280.415
macrophage cytokine productionGO:001093490.409
positive regulation by organism of immune response of other organism involved in symbiotic interactionGO:005255510.407
Mouse
peptidyl tyrosine phosphorylationGO:00181081430.406
Rat
lactationGO:0007595250.402
stress activated protein kinase signaling cascadeGO:0031098810.399
negative regulation of t helper 1 type immune responseGO:000282650.399
positive regulation of interleukin 1 alpha secretionGO:005071730.396
negative regulation of endopeptidase activityGO:0010951440.396
positive regulation of apoptotic processGO:00430652170.393
Rat
regulation of vasculature developmentGO:1901342880.392
transmembrane transportGO:00550854120.392
regulation of neuron apoptotic processGO:00435231220.389
protein catabolic processGO:00301632210.388
regulation of map kinase activityGO:00434051200.383
positive regulation of response to biotic stimulusGO:0002833150.383
Mouse
positive regulation of acute inflammatory responseGO:0002675160.382
positive regulation of extrinsic apoptotic signaling pathwayGO:2001238340.380
positive regulation of glial cell proliferationGO:006025240.380
lymphocyte chemotaxisGO:0048247100.375
natural killer cell mediated cytotoxicityGO:0042267290.372
regulation of thymocyte apoptotic processGO:0070243140.372
intracellular receptor signaling pathwayGO:0030522740.370
t cell apoptotic processGO:0070231390.369
carboxylic acid transportGO:00469421000.369
organic hydroxy compound metabolic processGO:19016152030.367
regulation of interleukin 23 productionGO:003266720.367
negative regulation of angiogenesisGO:0016525250.366
response to lipoteichoic acidGO:007039160.365
response to drugGO:0042493750.363
Mouse
positive regulation of interleukin 6 biosynthetic processGO:004541060.360
Mouse
positive regulation of protein import into nucleusGO:0042307260.360
Human
negative regulation of cyclin dependent protein serine threonine kinase activityGO:004573690.357
negative regulation of interferon gamma mediated signaling pathwayGO:006033610.353
somatic recombination of immunoglobulin gene segmentsGO:0016447420.353
activation of cysteine type endopeptidase activityGO:0097202270.352
regulation of endopeptidase activityGO:0052548890.350
interleukin 1 beta secretionGO:0050702160.350
alpha amino acid metabolic processGO:1901605590.349
response to hyperoxiaGO:005509320.348
defense response to fungusGO:0050832120.347
positive regulation of t cell extravasationGO:200040920.345
cell fate commitmentGO:00451652100.345
negative regulation of b cell apoptotic processGO:000290370.344
single organism nuclear importGO:1902593950.343
Human
negative regulation of ion transportGO:0043271280.341
mitochondrion organizationGO:00070051340.341
nucleocytoplasmic transportGO:00069131390.341
Human
extrinsic apoptotic signaling pathwayGO:00971911260.340
organonitrogen compound biosynthetic processGO:19015661920.340
cellular response to peptideGO:1901653920.337
negative regulation of myeloid dendritic cell activationGO:003088630.335
response to lithium ionGO:0010226100.332
lymphocyte activation involved in immune responseGO:0002285930.330
t cell differentiationGO:00302171740.330
angiogenesisGO:00015252010.329
tyrosine phosphorylation of stat1 proteinGO:004250830.327
modification of morphology or physiology of other organismGO:0035821180.326
Mouse
epithelial tube morphogenesisGO:00605623030.325
regulation of protein processingGO:0070613960.324
leukocyte homeostasisGO:0001776790.323
ossificationGO:00015032160.322
regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathwayGO:200126740.321
negative regulation of interferon gamma productionGO:0032689180.321
negative regulation of apoptotic signaling pathwayGO:20012341040.319
positive regulation of coagulationGO:0050820130.319
cellular response to steroid hormone stimulusGO:0071383330.319
positive regulation of transcription factor import into nucleusGO:004299380.315
Human
regulation of chemokine productionGO:0032642300.315
epidermis developmentGO:00085441870.314
activation of mapk activity involved in innate immune responseGO:003541920.314
protein processingGO:00164851630.310
positive regulation of tumor necrosis factor biosynthetic processGO:004253580.309
Human Mouse
positive regulation of apoptotic process involved in mammary gland involutionGO:006005840.309
myelinationGO:0042552740.305
blood coagulationGO:0007596760.303
t cell extravasationGO:007268340.302
negative regulation of inflammatory responseGO:0050728610.297
regulation of antibacterial peptide productionGO:000278610.294
modulation by organism of immune response of other organism involved in symbiotic interactionGO:005255210.294
Mouse
myd88 independent toll like receptor signaling pathwayGO:000275630.290
negative regulation of cell proliferationGO:00082852960.289
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.289
positive regulation of hypersensitivityGO:000288570.289
b cell activation involved in immune responseGO:0002312500.286
negative regulation of cysteine type endopeptidase activityGO:2000117220.286
t cell homeostasisGO:0043029350.286

Tlr4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.749
Human
disease of cellular proliferationDOID:1456600.749
Human
organ system cancerDOID:005068600.676
Human