Mus musculus

54 known processes

Pola2

polymerase (DNA directed), alpha 2

(Aliases: AI573378)

Pola2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular response to dna damage stimulusGO:00069742070.446
dna metabolic processGO:00062593030.385
dna repairGO:00062811070.366
double strand break repair via nonhomologous end joiningGO:0006303100.194
double strand break repairGO:0006302480.178
meiotic cell cycle processGO:1903046770.124
regulation of cell cycleGO:00517262810.114
meiosis iGO:0007127600.098
meiotic cell cycleGO:00513211220.089
organic cyclic compound catabolic processGO:19013612950.087
cellular nitrogen compound catabolic processGO:00442702800.083
cellular amine metabolic processGO:0044106440.081
single fertilizationGO:0007338820.078
rna dependent dna replicationGO:000627830.072
purine nucleoside triphosphate metabolic processGO:00091442260.071
apoptotic signaling pathwayGO:00971903060.071
dna dependent dna replicationGO:0006261240.071
Yeast
nucleus localizationGO:0051647200.068
dna biosynthetic processGO:0071897220.059
Yeast Rat
purine nucleoside metabolic processGO:00422782410.058
negative regulation of protein metabolic processGO:00512482820.055
cellular amino acid metabolic processGO:00065201030.054
ribonucleoside triphosphate metabolic processGO:00091992200.052
regulation of cellular amino acid metabolic processGO:000652150.051
regulation of mitotic cell cycle phase transitionGO:1901990730.050
fertilizationGO:00095661270.050
nucleobase containing small molecule metabolic processGO:00550863520.049
organonitrogen compound catabolic processGO:19015652640.049
glycosyl compound metabolic processGO:19016572460.047
nucleoside phosphate catabolic processGO:19012922220.046
nucleoside phosphate metabolic processGO:00067533380.045
regulation of cellular amine metabolic processGO:0033238200.045
meiotic nuclear divisionGO:00071261150.045
male gamete generationGO:00482322850.043
cellular ketone metabolic processGO:0042180840.043
organelle localizationGO:00516401790.042
glycosyl compound catabolic processGO:19016582060.042
negative regulation of cell cycleGO:00457861230.042
positive regulation of cellular amino acid metabolic processGO:004576430.041
dna dependent dna replication maintenance of fidelityGO:004500530.041
regulation of cellular ketone metabolic processGO:0010565660.040
nucleoside metabolic processGO:00091162460.039
recombinational repairGO:0000725210.039
immune effector processGO:00022523210.038
engulfment of apoptotic cellGO:004365230.038
peptidyl amino acid modificationGO:00181933360.037
purine ribonucleoside triphosphate metabolic processGO:00092052200.037
ribonucleotide metabolic processGO:00092592910.036
purine containing compound metabolic processGO:00725213110.036
cytokine productionGO:00018163190.036
double strand break repair via homologous recombinationGO:0000724210.035
membrane organizationGO:00610242450.035
ribonucleoside metabolic processGO:00091192450.034
purine ribonucleoside metabolic processGO:00461282410.033
positive regulation of cellular amine metabolic processGO:003324050.033
ribonucleotide catabolic processGO:00092612080.032
amine metabolic processGO:0009308450.032
establishment of organelle localizationGO:00516561220.032
regulation of cytokine productionGO:00018172660.032
nucleotide metabolic processGO:00091173320.032
spermatogenesisGO:00072832840.032
heterocycle catabolic processGO:00467002800.031
multicellular organism growthGO:00352641610.031
negative regulation of cellular component organizationGO:00511291940.031
chromatin organizationGO:00063252060.031
macromolecule catabolic processGO:00090572810.031
gonad developmentGO:00084061410.031
development of primary sexual characteristicsGO:00451371430.029
chromatin modificationGO:00165681870.029
intracellular protein transportGO:00068862040.029
purine ribonucleoside triphosphate catabolic processGO:00092071990.029
nucleoside triphosphate metabolic processGO:00091412300.028
nucleotide catabolic processGO:00091662170.028
regulation of defense responseGO:00313472330.027
positive regulation of hydrolase activityGO:00513451480.027
purine nucleotide catabolic processGO:00061952110.027
small gtpase mediated signal transductionGO:0007264970.027
dna replicationGO:0006260520.026
regulation of multi organism processGO:00439001110.026
regulation of kinase activityGO:00435492490.026
regulation of anatomical structure sizeGO:00900661780.025
nucleoside triphosphate catabolic processGO:00091432050.025
aromatic compound catabolic processGO:00194392860.025
dna conformation changeGO:0071103370.025
ribonucleoside triphosphate catabolic processGO:00092031990.025
cell divisionGO:00513011200.025
cation transportGO:00068123990.025
regulation of transferase activityGO:00513382630.025
regulation of organelle organizationGO:00330432890.024
purine ribonucleotide metabolic processGO:00091502900.024
protein polymerizationGO:0051258570.024
regulation of cellular catabolic processGO:00313292420.024
establishment or maintenance of cytoskeleton polarityGO:003095220.024
purine containing compound catabolic processGO:00725232130.023
nuclear transportGO:00511691390.023
microtubule cytoskeleton organizationGO:00002261570.023
regulation of proteolysisGO:00301621640.023
purine nucleoside triphosphate catabolic processGO:00091462030.023
purine nucleoside catabolic processGO:00061522050.023
purine ribonucleoside catabolic processGO:00461302050.023
positive regulation of protein modification processGO:00314012990.022
regulation of cell cycle processGO:00105641600.022
intrinsic apoptotic signaling pathwayGO:00971931320.022
purine nucleotide metabolic processGO:00061633020.022
protein maturationGO:00516041760.022
non recombinational repairGO:0000726100.022
ras protein signal transductionGO:0007265770.022
negative regulation of organelle organizationGO:0010639900.022
posttranscriptional regulation of gene expressionGO:00106081550.021
signal transduction by p53 class mediatorGO:0072331510.021
regulation of chromosome organizationGO:0033044830.021
lymphocyte proliferationGO:00466511640.021
dna endoreduplicationGO:004202340.020
cell adhesionGO:00071553290.020
regulation of membrane potentialGO:00423911920.020
regulation of cellular component biogenesisGO:00440871810.020
histone modificationGO:00165701590.020
negative regulation of cell proliferationGO:00082852960.020
purine ribonucleotide catabolic processGO:00091542080.020
microtubule based processGO:00070172360.019
regulation of mitotic cell cycleGO:00073461260.019
divalent inorganic cation transportGO:00725111780.019
protein catabolic processGO:00301632210.019
regulation of cell motilityGO:20001452360.019
muscle tissue developmentGO:00605373080.019
blood vessel morphogenesisGO:00485142850.019
cell cycle g1 s phase transitionGO:0044843570.019
rho protein signal transductionGO:0007266320.019
ribose phosphate metabolic processGO:00196932910.019
cellular response to cytokine stimulusGO:00713451890.019
leukocyte differentiationGO:00025213420.019
receptor mediated endocytosisGO:0006898510.019
single organism nuclear importGO:1902593950.019
ion transmembrane transportGO:00342203610.019
nuclear dna replicationGO:003326030.019
regulation of apoptotic signaling pathwayGO:20012331970.018
cellular component assembly involved in morphogenesisGO:00109271390.018
transmembrane transportGO:00550854120.018
negative regulation of molecular functionGO:00440922580.018
negative regulation of immune system processGO:00026832090.018
germ cell developmentGO:00072811850.018
mitotic cell cycle processGO:19030471590.018
positive regulation of cell deathGO:00109422240.018
regulation of ras gtpase activityGO:0032318880.018
regulation of cellular component sizeGO:00325351210.018
regulation of cell cycle phase transitionGO:1901987770.018
establishment of protein localization to organelleGO:00725941180.018
regulation of cell migrationGO:00303342190.018
reactive oxygen species metabolic processGO:0072593840.018
cellular ion homeostasisGO:00068731650.018
organelle fissionGO:00482851700.018
maintenance of locationGO:0051235890.018
regulation of protein kinase activityGO:00458592320.018
regulation of cell activationGO:00508652890.018
protein processingGO:00164851630.018
regulation of reactive oxygen species metabolic processGO:2000377400.018
leukocyte proliferationGO:00706611720.017
mapk cascadeGO:00001652810.017
inorganic ion transmembrane transportGO:00986602340.017
atp catabolic processGO:0006200550.017
purine ribonucleoside monophosphate metabolic processGO:0009167800.017
cellular protein catabolic processGO:00442571550.017
cellular macromolecule catabolic processGO:00442652060.017
negative regulation of cellular protein metabolic processGO:00322692470.017
regulation of protein localizationGO:00328802310.017
ribonucleoside monophosphate metabolic processGO:0009161800.017
regulation of secretion by cellGO:19035302490.017
negative regulation of cellular amino acid metabolic processGO:004576300.017
ribonucleoside catabolic processGO:00424542060.017
endomembrane system organizationGO:00102561470.017
response to organonitrogen compoundGO:00102432460.017
chromosome organization involved in meiosisGO:0070192390.017
regulation of homeostatic processGO:00328441820.016
carbohydrate derivative catabolic processGO:19011362310.016
negative regulation of intracellular signal transductionGO:19025321670.016
dna recombinationGO:0006310920.016
gland developmentGO:00487323300.016
cell type specific apoptotic processGO:00972852680.016
regulation of cellular response to stressGO:00801351590.016
nucleoside catabolic processGO:00091642060.016
translationGO:0006412930.016
protein import into nucleusGO:0006606950.016
regulation of establishment of protein localizationGO:00702011810.016
male meiosisGO:0007140370.016
positive regulation of programmed cell deathGO:00430682180.016
organophosphate catabolic processGO:00464342320.016
protein targetingGO:00066051430.016
cellular protein complex assemblyGO:00436231160.016
nucleoside monophosphate metabolic processGO:0009123850.016
endocytosisGO:00068971680.016
lymphocyte mediated immunityGO:00024491390.016
regulation of chromatin silencingGO:003193520.016
negative regulation of phosphorylationGO:00423261660.015
lymphocyte differentiationGO:00300982420.015
cellular homeostasisGO:00197252400.015
phagocytosisGO:0006909660.015
striated muscle tissue developmentGO:00147062930.015
interspecies interaction between organismsGO:0044419830.015
t cell activationGO:00421102890.015
reciprocal dna recombinationGO:0035825160.015
atp metabolic processGO:0046034750.015
divalent metal ion transportGO:00708381720.015
spermatid developmentGO:00072861080.015
innate immune responseGO:00450871570.015
regulation of translationGO:0006417710.015
negative regulation of dna replicationGO:000815640.015
leukocyte mediated immunityGO:00024431740.015
response to oxidative stressGO:00069791230.015
somatic diversification of immune receptorsGO:0002200530.015
negative regulation of phosphorus metabolic processGO:00105631840.015
striated muscle myosin thick filament assemblyGO:007168810.015
regulation of ras protein signal transductionGO:00465781140.015
regulation of cell cycle g1 s phase transitionGO:1902806350.015
mitotic cell cycleGO:00002781950.015
cation homeostasisGO:00550802120.014
regulation of leukocyte proliferationGO:00706631210.014
actin cytoskeleton organizationGO:00300362200.014
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.014
modification dependent protein catabolic processGO:00199411330.014
positive regulation of apoptotic signaling pathwayGO:2001235950.014
digestive system developmentGO:00551232000.014
activation of immune responseGO:00022531380.014
positive regulation of protein phosphorylationGO:00019342420.014
cell growthGO:00160491300.014
negative regulation of protein modification processGO:00314001630.014
synapsisGO:0007129340.014
protein modification by small protein conjugation or removalGO:00706472070.014
action potentialGO:0001508780.014
negative regulation of apoptotic signaling pathwayGO:20012341040.014
negative regulation of cell cycle phase transitionGO:1901988480.014
regulation of purine nucleotide metabolic processGO:19005421690.014
purine ribonucleoside monophosphate catabolic processGO:0009169570.014
ubiquitin dependent protein catabolic processGO:00065111290.014
regulation of t cell proliferationGO:0042129920.014
regulation of bindingGO:00510981110.014
regulation of lymphocyte proliferationGO:00506701170.014
stem cell differentiationGO:00488632680.014
regulation of lymphocyte activationGO:00512492400.014
regulation of secretionGO:00510462740.014
multicellular organismal homeostasisGO:00488711640.014
regulation of mapk cascadeGO:00434082480.013
female meiosis chromosome segregationGO:001632110.013
sequestering of metal ionGO:0051238190.013
t cell proliferationGO:00420981200.013
oxidation reduction processGO:00551143420.013
negative regulation of cellular amine metabolic processGO:003323910.013
immune response regulating signaling pathwayGO:00027641250.013
establishment or maintenance of microtubule cytoskeleton polarityGO:003095110.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.013
negative regulation of protein processingGO:0010955790.013
leukocyte activation involved in immune responseGO:00023661260.013
ribonucleoside monophosphate catabolic processGO:0009158570.013
myosin filament assemblyGO:003103420.013
cellular chemical homeostasisGO:00550822150.013
cell activation involved in immune responseGO:00022631260.013
protein modification by small protein conjugationGO:00324461870.013
cell fate commitmentGO:00451652100.013
wnt signaling pathwayGO:00160551880.013
intra s dna damage checkpointGO:003157340.013
positive regulation of cell cycleGO:0045787920.013
response to acid chemicalGO:00011011110.013
skeletal system developmentGO:00015013560.013
carbohydrate metabolic processGO:00059752300.013
metal ion homeostasisGO:00550651890.013
sister chromatid segregationGO:0000819200.012
extracellular structure organizationGO:00430621480.012
response to inorganic substanceGO:0010035960.012
production of molecular mediator of immune responseGO:00024401030.012
negative regulation of phosphate metabolic processGO:00459361840.012
regulation of neuron differentiationGO:00456642810.012
blastocyst developmentGO:0001824800.012
regulation of nucleoside metabolic processGO:00091181300.012
genitalia developmentGO:0048806370.012
sequestering of calcium ionGO:0051208180.012
negative regulation of cell developmentGO:00107211690.012
transmission of nerve impulseGO:0019226760.012
negative regulation of nervous system developmentGO:00519611560.012
negative regulation of chromatin silencingGO:003193610.012
regulation of protein maturationGO:1903317960.012
camera type eye developmentGO:00430102660.012
angiogenesisGO:00015252010.012
morphogenesis of a branching structureGO:00017632030.012
actin filament polymerizationGO:0030041440.012
regulation of hydrolase activityGO:00513362460.012
locomotory behaviorGO:00076261950.012
nucleocytoplasmic transportGO:00069131390.012
positive regulation of nucleotide metabolic processGO:00459811140.012
lateral inhibitionGO:004633110.012
localization within membraneGO:005166840.012
regulation of protein complex assemblyGO:0043254830.012
calcium ion transportGO:00068161590.012
sensory perceptionGO:00076002450.012
regionalizationGO:00030023370.012
negative regulation of proteolysisGO:0045861740.012
anion transportGO:00068201770.012
regulation of gtp catabolic processGO:00331241130.012
telencephalon developmentGO:00215371860.012
nucleus organizationGO:0006997450.012
regulation of protein catabolic processGO:00421761080.012
regulation of actin filament based processGO:0032970990.012
signal transduction involved in dna damage checkpointGO:007242230.012
symbiosis encompassing mutualism through parasitismGO:0044403830.012
nitrogen compound transportGO:00717052710.012
epithelial tube morphogenesisGO:00605623030.012
negative regulation of mitotic cell cycleGO:0045930580.011
dna damage response signal transduction resulting in transcriptionGO:004277220.011
bone developmentGO:00603481200.011
nucleic acid phosphodiester bond hydrolysisGO:0090305490.011
methylationGO:00322591340.011
negative regulation of protein maturationGO:1903318790.011
hematopoietic progenitor cell differentiationGO:00022441430.011
b cell activationGO:00421131610.011
forebrain developmentGO:00309003020.011
signal transduction in absence of ligandGO:0038034550.011
cellular lipid metabolic processGO:00442553230.011
multicellular organismal signalingGO:0035637910.011
circulatory system processGO:00030131970.011
regulation of ion transportGO:00432692150.011
dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697820.011
actin polymerization or depolymerizationGO:0008154540.011
regulation of actin filament lengthGO:0030832450.011
modification dependent macromolecule catabolic processGO:00436321330.011
morphogenesis of a branching epitheliumGO:00611381930.011
actin filament organizationGO:00070151130.011
intestinal epithelial structure maintenanceGO:006072940.011
regulation of lymphocyte mediated immunityGO:0002706840.011
myosin filament organizationGO:003103330.011
mitotic cytokinesisGO:000028140.011
response to molecule of bacterial originGO:00022371430.011
positive regulation of nucleotide catabolic processGO:0030813880.011
stem cell maintenanceGO:00198271300.011
extrinsic apoptotic signaling pathway in absence of ligandGO:0097192550.011
carbohydrate derivative biosynthetic processGO:19011371830.011
immunoglobulin productionGO:0002377730.011
compound eye developmentGO:004874910.011
regulation of innate immune responseGO:0045088910.011
positive regulation of purine nucleotide catabolic processGO:0033123880.011
gene silencingGO:0016458380.011
glycoprotein metabolic processGO:00091001160.011
inflammatory responseGO:00069542440.011
regulation of protein transportGO:00512231630.011
divalent inorganic cation homeostasisGO:00725071380.011
protein methylationGO:0006479810.011
proteasomal protein catabolic processGO:0010498980.011
cell agingGO:0007569350.011
positive regulation of secretionGO:00510471300.011
histone methylationGO:0016571710.011
negative regulation of cytokine productionGO:0001818840.011
synaptic transmissionGO:00072683290.011
covalent chromatin modificationGO:00165691630.011
regulation of dna replicationGO:0006275170.011
proteolysis involved in cellular protein catabolic processGO:00516031470.011
negative regulation of growthGO:0045926990.011
somatic diversification of immune receptors via germline recombination within a single locusGO:0002562510.011
gtp catabolic processGO:00061841430.011
regulation of cysteine type endopeptidase activityGO:2000116650.011
leukocyte migrationGO:00509001240.010
regulation of cytoskeleton organizationGO:00514931220.010
regulation of actin polymerization or depolymerizationGO:0008064450.010
axonogenesisGO:00074092740.010
regulation of synaptic growth at neuromuscular junctionGO:000858240.010
protein alkylationGO:0008213810.010
digestive tract developmentGO:00485651900.010
regulation of cell projection organizationGO:00313442060.010
regulation of rho protein signal transductionGO:0035023710.010
regulation of transcription by chromatin organizationGO:003440100.010
positive regulation of t cell receptor signaling pathwayGO:005086240.010
stem cell developmentGO:00488642190.010
response to lipopolysaccharideGO:00324961280.010
cilium morphogenesisGO:00602711020.010
adaptive immune responseGO:00022501550.010
neuron migrationGO:00017641220.010
wound healingGO:00420601570.010
regulation of g1 s transition of mitotic cell cycleGO:2000045350.010
blood circulationGO:00080151950.010
membrane invaginationGO:0010324170.010
response to endoplasmic reticulum stressGO:0034976530.010
regulation of intrinsic apoptotic signaling pathwayGO:2001242610.010
cytokine mediated signaling pathwayGO:00192211150.010
negative regulation of protein phosphorylationGO:00019331260.010
regulation of inflammatory responseGO:00507271470.010
cellular response to abiotic stimulusGO:0071214560.010

Pola2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.043
disease of cellular proliferationDOID:1456600.043
immune system diseaseDOID:291400.042
disease of anatomical entityDOID:700.042
aplastic anemiaDOID:1244900.041
hematopoietic system diseaseDOID:7400.041
anemiaDOID:235500.041
congenital hypoplastic anemiaDOID:134200.041
bone marrow diseaseDOID:496100.041
organ system cancerDOID:005068600.021
nervous system diseaseDOID:86300.015
central nervous system diseaseDOID:33100.011
disease of metabolismDOID:001466700.011