Mus musculus

28 known processes

Pola1

polymerase (DNA directed), alpha 1

(Aliases: Pola,AW321876)

Pola1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
dna metabolic processGO:00062593030.945
double strand break repairGO:0006302480.840
Human Yeast
meiosis iGO:0007127600.772
meiotic cell cycle processGO:1903046770.725
Yeast
telomere cappingGO:001623340.564
dna dependent dna replicationGO:0006261240.546
Human
chromosome organization involved in meiosisGO:0070192390.425
meiotic cell cycleGO:00513211220.416
Yeast
meiotic chromosome segregationGO:0045132190.357
cellular nitrogen compound catabolic processGO:00442702800.305
microtubule cytoskeleton organizationGO:00002261570.301
synapsisGO:0007129340.283
meiotic nuclear divisionGO:00071261150.274
dna replicationGO:0006260520.259
gonad developmentGO:00084061410.253
dna conformation changeGO:0071103370.244
protein import into nucleusGO:0006606950.226
dna biosynthetic processGO:0071897220.225
purine nucleotide catabolic processGO:00061952110.218
establishment of organelle localizationGO:00516561220.188
Worm
dna repairGO:00062811070.188
Human Yeast
purine ribonucleotide metabolic processGO:00091502900.177
negative regulation of cell cycleGO:00457861230.175
regulation of cell cycleGO:00517262810.171
double strand break repair via homologous recombinationGO:0000724210.164
endocytosisGO:00068971680.155
receptor mediated endocytosisGO:0006898510.154
establishment of protein localization to organelleGO:00725941180.146
organelle assemblyGO:00709251770.145
protein targetingGO:00066051430.145
recombinational repairGO:0000725210.145
nucleocytoplasmic transportGO:00069131390.140
development of primary sexual characteristicsGO:00451371430.135
nucleoside phosphate catabolic processGO:19012922220.133
membrane organizationGO:00610242450.131
nuclear transportGO:00511691390.129
intrinsic apoptotic signaling pathwayGO:00971931320.116
nucleobase containing small molecule metabolic processGO:00550863520.114
glycosyl compound metabolic processGO:19016572460.112
dna endoreduplicationGO:004202340.109
organic cyclic compound catabolic processGO:19013612950.108
regulation of dna dependent dna replicationGO:009032980.107
regulation of apoptotic signaling pathwayGO:20012331970.106
apoptotic signaling pathwayGO:00971903060.105
nucleotide catabolic processGO:00091662170.101
extrinsic apoptotic signaling pathwayGO:00971911260.101
ribonucleotide catabolic processGO:00092612080.097
protein catabolic processGO:00301632210.095
purine nucleoside triphosphate catabolic processGO:00091462030.093
purine nucleoside metabolic processGO:00422782410.093
cellular response to radiationGO:0071478280.092
intracellular protein transportGO:00068862040.091
protein importGO:00170381010.090
cellular response to abiotic stimulusGO:0071214560.088
maintenance of locationGO:0051235890.087
cellular macromolecule catabolic processGO:00442652060.087
microtubule organizing center organizationGO:0031023280.086
regulation of cytoskeleton organizationGO:00514931220.084
intra s dna damage checkpointGO:003157340.083
single organism nuclear importGO:1902593950.083
mitotic chromosome condensationGO:000707610.082
nuclear importGO:0051170950.082
microtubule based processGO:00070172360.079
reciprocal dna recombinationGO:0035825160.078
female meiotic divisionGO:0007143210.077
purine containing compound metabolic processGO:00725213110.076
nucleotide metabolic processGO:00091173320.074
macromolecule catabolic processGO:00090572810.073
purine nucleoside catabolic processGO:00061522050.073
protein localization to nucleusGO:00345041210.072
dna packagingGO:0006323300.072
purine nucleoside triphosphate metabolic processGO:00091442260.070
genitalia developmentGO:0048806370.069
amine metabolic processGO:0009308450.068
engulfment of apoptotic cellGO:004365230.068
cellular protein complex assemblyGO:00436231160.068
regulation of cellular amino acid metabolic processGO:000652150.066
heterocycle catabolic processGO:00467002800.065
cellular ketone metabolic processGO:0042180840.065
telomere maintenanceGO:0000723190.065
cellular response to dna damage stimulusGO:00069742070.064
Human Yeast
regulation of meiosis iGO:006063170.064
nucleoside phosphate metabolic processGO:00067533380.063
positive regulation of hydrolase activityGO:00513451480.063
cellular amino acid metabolic processGO:00065201030.062
regulation of organelle organizationGO:00330432890.060
ribonucleotide metabolic processGO:00092592910.059
cellular response to organonitrogen compoundGO:00714171450.058
ribose phosphate metabolic processGO:00196932910.056
ribonucleoside metabolic processGO:00091192450.056
anatomical structure homeostasisGO:00602491450.055
regulation of kinase activityGO:00435492490.054
male meiosisGO:0007140370.054
nucleoside metabolic processGO:00091162460.054
regulation of transferase activityGO:00513382630.053
glycosyl compound catabolic processGO:19016582060.053
cell divisionGO:00513011200.052
organonitrogen compound catabolic processGO:19015652640.052
nucleic acid phosphodiester bond hydrolysisGO:0090305490.052
male gamete generationGO:00482322850.051
regulation of hydrolase activityGO:00513362460.051
spermatogenesisGO:00072832840.050
female meiosis chromosome segregationGO:001632110.050
organelle fissionGO:00482851700.050
cellular response to ionizing radiationGO:0071479110.049
regulation of cellular ketone metabolic processGO:0010565660.049
protein localization to organelleGO:00333651850.049
mitotic g2 dna damage checkpointGO:000709580.049
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.048
regulation of cell cycle processGO:00105641600.048
cytoplasmic transportGO:00164822340.046
purine ribonucleoside triphosphate metabolic processGO:00092052200.046
negative regulation of cellular component organizationGO:00511291940.046
aromatic compound catabolic processGO:00194392860.046
nucleoside catabolic processGO:00091642060.046
ribonucleoside triphosphate metabolic processGO:00091992200.045
regulation of mitosisGO:0007088290.045
regulation of cell divisionGO:0051302760.044
cellular amine metabolic processGO:0044106440.044
response to organonitrogen compoundGO:00102432460.044
negative regulation of mitotic cell cycle phase transitionGO:1901991450.043
purine nucleotide metabolic processGO:00061633020.043
regulation of cellular component biogenesisGO:00440871810.042
carbohydrate derivative catabolic processGO:19011362310.041
positive regulation of cellular amino acid metabolic processGO:004576430.041
mitotic cell cycle processGO:19030471590.041
regulation of mitotic cell cycle phase transitionGO:1901990730.041
response to radiationGO:00093141650.041
negative regulation of cell cycle processGO:0010948690.041
cell type specific apoptotic processGO:00972852680.041
spindle assembly involved in female meiosisGO:000705630.040
rho protein signal transductionGO:0007266320.040
cellular protein catabolic processGO:00442571550.040
centrosome organizationGO:0051297260.039
cell fate commitmentGO:00451652100.039
regulation of cellular amine metabolic processGO:0033238200.039
mitotic cytokinesisGO:000028140.039
spindle assembly involved in meiosisGO:009030640.038
positive regulation of protein kinase activityGO:00458601440.038
regulation of centriole replicationGO:004659910.037
mitotic cell cycleGO:00002781950.036
purine ribonucleotide catabolic processGO:00091542080.036
response to organic cyclic compoundGO:00140701980.035
regulation of purine nucleotide metabolic processGO:19005421690.035
mitochondrion organizationGO:00070051340.034
positive regulation of cellular amine metabolic processGO:003324050.034
translesion synthesisGO:001998510.034
purine ribonucleoside metabolic processGO:00461282410.034
purine ribonucleoside triphosphate catabolic processGO:00092071990.033
nucleoside triphosphate catabolic processGO:00091432050.032
regulation of dna replicationGO:0006275170.032
small gtpase mediated signal transductionGO:0007264970.032
regulation of nucleoside metabolic processGO:00091181300.032
spindle assembly involved in mitosisGO:009030740.032
muscle cell differentiationGO:00426922610.032
regulation of protein kinase activityGO:00458592320.032
negative regulation of meiotic cell cycleGO:0051447140.031
positive regulation of protein modification processGO:00314012990.031
organophosphate catabolic processGO:00464342320.031
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.031
purine ribonucleoside monophosphate metabolic processGO:0009167800.030
regulation of chromosome organizationGO:0033044830.030
nuclear dna replicationGO:003326030.030
germ cell developmentGO:00072811850.029
nucleoside monophosphate metabolic processGO:0009123850.029
regulation of cellular catabolic processGO:00313292420.029
regulation of mitotic cell cycleGO:00073461260.029
purine containing compound catabolic processGO:00725232130.029
mitotic recombinationGO:000631230.028
heterochromatin assemblyGO:003150720.028
striated muscle myosin thick filament assemblyGO:007168810.028
positive regulation of cell developmentGO:00107202370.027
dna catabolic processGO:0006308190.027
multicellular organism growthGO:00352641610.027
protein oligomerizationGO:0051259670.027
blood vessel morphogenesisGO:00485142850.027
chromosome segregationGO:0007059480.026
negative regulation of dna dependent dna replicationGO:200010410.026
cellular response to oxidative stressGO:0034599760.026
negative regulation of cell cycle phase transitionGO:1901988480.026
negative regulation of organelle organizationGO:0010639900.026
ribonucleoside catabolic processGO:00424542060.026
regulation of chromatin modificationGO:1903308570.026
digestive tract morphogenesisGO:00485461470.025
regulation of protein localizationGO:00328802310.025
regulation of dna recombinationGO:0000018340.025
microtubule cytoskeleton organization involved in mitosisGO:190285040.025
purine nucleoside monophosphate metabolic processGO:0009126810.024
protein autophosphorylationGO:0046777610.024
wnt signaling pathwayGO:00160551880.024
innate immune responseGO:00450871570.024
myosin filament organizationGO:003103330.024
positive regulation of nervous system developmentGO:00519622210.024
cell cycle checkpointGO:0000075470.024
heterochromatin organizationGO:007082840.024
cellular component assembly involved in morphogenesisGO:00109271390.023
regulation of nucleotide metabolic processGO:00061401690.023
negative regulation of nuclear divisionGO:0051784190.023
chromatin assembly or disassemblyGO:0006333160.023
t cell apoptotic processGO:0070231390.023
response to light stimulusGO:00094161350.023
mrna 3 end processingGO:0031124160.023
response to oxidative stressGO:00069791230.023
multi multicellular organism processGO:00447061090.022
response to denervation involved in regulation of muscle adaptationGO:001489440.022
dna catabolic process endonucleolyticGO:0000737150.022
reciprocal meiotic recombinationGO:0007131160.022
dna recombinationGO:0006310920.021
positive regulation of protein serine threonine kinase activityGO:00719021060.021
cellular response to organic cyclic compoundGO:0071407870.021
positive regulation of peptidase activityGO:0010952490.021
dna dependent dna replication maintenance of fidelityGO:004500530.021
cellular response to hormone stimulusGO:00328701500.021
actomyosin structure organizationGO:0031032560.021
lateral inhibitionGO:004633110.021
striated muscle cell developmentGO:00550021250.021
methylationGO:00322591340.021
protein maturationGO:00516041760.021
neuron deathGO:00709971540.021
peptidyl amino acid modificationGO:00181933360.020
regulation of endopeptidase activityGO:0052548890.020
response to uvGO:0009411440.020
regulation of nuclear cell cycle dna replicationGO:003326220.020
nucleoside triphosphate metabolic processGO:00091412300.020
placenta developmentGO:00018901400.020
establishment or maintenance of cell polarityGO:0007163860.020
neuron apoptotic processGO:00514021420.020
negative regulation of molecular functionGO:00440922580.020
regulation of protein depolymerizationGO:1901879260.019
regulation of transcription by chromatin organizationGO:003440100.019
regulation of cellular response to stressGO:00801351590.019
sister chromatid segregationGO:0000819200.019
chromatin organizationGO:00063252060.019
regulation of histone modificationGO:0031056560.019
response to inorganic substanceGO:0010035960.019
cellular protein complex disassemblyGO:0043624360.019
positive regulation of purine nucleotide catabolic processGO:0033123880.018
leukocyte proliferationGO:00706611720.018
double strand break repair via nonhomologous end joiningGO:0006303100.018
Human
positive regulation of nucleotide catabolic processGO:0030813880.018
membrane invaginationGO:0010324170.018
compound eye developmentGO:004874910.018
dna methylationGO:0006306430.018
muscle tissue developmentGO:00605373080.018
carbohydrate derivative biosynthetic processGO:19011371830.018
regulation of actin filament based processGO:0032970990.018
negative regulation of phosphate metabolic processGO:00459361840.018
dna modificationGO:0006304500.018
protein secretionGO:00093061110.018
regulation of neuron deathGO:19012141340.018
posttranscriptional regulation of gene expressionGO:00106081550.017
positive regulation of neuron differentiationGO:00456661410.017
atp catabolic processGO:0006200550.017
negative regulation of cellular amine metabolic processGO:003323910.017
cdc42 protein signal transductionGO:003248800.017
sensory perceptionGO:00076002450.017
ras protein signal transductionGO:0007265770.017
cell agingGO:0007569350.017
positive regulation of nucleoside metabolic processGO:0045979910.017
cellular lipid metabolic processGO:00442553230.017
negative regulation of dna replicationGO:000815640.017
regulation of dna endoreduplicationGO:003287530.017
positive regulation of programmed cell deathGO:00430682180.016
female gamete generationGO:0007292740.016
purine ribonucleoside catabolic processGO:00461302050.016
regulation of protein serine threonine kinase activityGO:00719001570.016
nuclear divisionGO:00002801580.016
regulation of membrane potentialGO:00423911920.016
digestive system developmentGO:00551232000.016
dna duplex unwindingGO:003250870.016
positive regulation of cell deathGO:00109422240.016
locomotory behaviorGO:00076261950.016
regulation of cysteine type endopeptidase activityGO:2000116650.016
regulation of rho gtpase activityGO:0032319580.016
response to purine containing compoundGO:0014074280.016
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630570.015
regulation of chromatin silencingGO:003193520.015
interleukin 1 alpha secretionGO:005070330.015
negative regulation of microtubule polymerization or depolymerizationGO:0031111150.015
myosin filament assemblyGO:003103420.015
muscle cell developmentGO:00550011330.015
angiogenesisGO:00015252010.015
regulation of purine nucleotide catabolic processGO:00331211220.015
apoptotic mitochondrial changesGO:0008637480.015
response to growth factorGO:00708481980.015
regulation of cell cycle phase transitionGO:1901987770.015
regulation of wnt signaling pathwayGO:00301111230.015
regulation of peptidase activityGO:0052547960.015
organophosphate biosynthetic processGO:00904071220.015
cytokinetic processGO:003250620.015
actin cytoskeleton organizationGO:00300362200.015
regulation of cell projection organizationGO:00313442060.015
developmental maturationGO:00217001930.014
cellular response to growth factor stimulusGO:00713631970.014
positive regulation of transferase activityGO:00513471670.014
positive regulation of cellular component biogenesisGO:0044089940.014
nucleus organizationGO:0006997450.014
peptidyl serine phosphorylationGO:0018105740.014
axonogenesisGO:00074092740.014
endomembrane system organizationGO:00102561470.014
positive regulation of gtp catabolic processGO:0033126850.014
protein import into nucleus translocationGO:0000060120.014
kinetochore organizationGO:005138320.014
lymphocyte proliferationGO:00466511640.014
positive regulation of organelle organizationGO:00106381280.014
dna alkylationGO:0006305430.014
response to topologically incorrect proteinGO:0035966250.014
positive regulation of purine nucleotide metabolic processGO:19005441140.013
nitrogen compound transportGO:00717052710.013
negative regulation of phosphorylationGO:00423261660.013
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281620.013
positive regulation of apoptotic processGO:00430652170.013
negative regulation of apoptotic signaling pathwayGO:20012341040.013
developmental cell growthGO:0048588840.013
regulation of cell motilityGO:20001452360.013
skeletal muscle organ developmentGO:00605381630.013
organelle localizationGO:00516401790.013
Worm
response to ionizing radiationGO:0010212420.013
dendrite developmentGO:00163581150.013
regulation of neuron apoptotic processGO:00435231220.013
dna damage checkpointGO:0000077260.013
neural precursor cell proliferationGO:00613511210.013
morphogenesis of a branching epitheliumGO:00611381930.013
positive regulation of cysteine type endopeptidase activityGO:2001056390.013
positive regulation of protein transportGO:0051222930.013
inflammatory responseGO:00069542440.013
regulation of protein localization to nucleusGO:1900180600.013
regulation of protein transportGO:00512231630.013
proteasomal protein catabolic processGO:0010498980.013
response to lipopolysaccharideGO:00324961280.013
atp metabolic processGO:0046034750.012
neuron migrationGO:00017641220.012
positive regulation of secretionGO:00510471300.012
mapk cascadeGO:00001652810.012
regulation of leukocyte apoptotic processGO:2000106560.012
negative regulation of kinase activityGO:0033673810.012
viral entry into host cellGO:0046718150.012
male meiosis iGO:0007141160.012
i kappab kinase nf kappab signalingGO:0007249850.012
purine nucleoside monophosphate catabolic processGO:0009128580.012
negative regulation of cell divisionGO:0051782240.012
er nucleus signaling pathwayGO:0006984270.012
regulation of proteolysisGO:00301621640.012
rna catabolic processGO:0006401290.012
cytokine productionGO:00018163190.012
phagocytosisGO:0006909660.012
apoptotic nuclear changesGO:003026290.012
cellular response to lipidGO:00713961450.012
positive regulation of rac gtpase activityGO:0032855140.012
gene silencingGO:0016458380.012
epithelial tube morphogenesisGO:00605623030.012
developmental growth involved in morphogenesisGO:00605601380.012
centromere complex assemblyGO:003450830.012
regulation of cell activationGO:00508652890.012
dna replication initiationGO:000627050.012
Human
spermatid developmentGO:00072861080.012
regulation of neuron differentiationGO:00456642810.012
negative regulation of cellular protein metabolic processGO:00322692470.012
zymogen activationGO:0031638410.012
negative regulation of cellular amino acid metabolic processGO:004576300.012
cell maturationGO:00484691270.012
mitotic cell cycle checkpointGO:0007093310.012
embryonic placenta developmentGO:0001892980.012
regulation of ras gtpase activityGO:0032318880.012
dna hypermethylationGO:004402630.011
positive regulation of gtpase activityGO:0043547850.011
canonical wnt signaling pathwayGO:00600701300.011
urogenital system developmentGO:00016552610.011
establishment or maintenance of microtubule cytoskeleton polarityGO:003095110.011
leukocyte differentiationGO:00025213420.011
ribonucleoside monophosphate catabolic processGO:0009158570.011
histone modificationGO:00165701590.011
regulation of bindingGO:00510981110.011
cellular response to peptideGO:1901653920.011
srebp signaling pathwayGO:003293340.011
cellular component disassembly involved in execution phase of apoptosisGO:000692190.011
response to steroid hormoneGO:0048545560.011
apoptotic dna fragmentationGO:000630970.011
positive regulation of cell cycle processGO:0090068610.011
cellular response to acid chemicalGO:0071229680.011
adult behaviorGO:00305341350.011
rna 3 end processingGO:0031123200.011
extrinsic apoptotic signaling pathway in absence of ligandGO:0097192550.011
regulation of interleukin 1 alpha productionGO:003265040.011
response to hypoxiaGO:0001666580.011
anion transportGO:00068201770.011
neural tube formationGO:00018411080.011
apoptotic cell clearanceGO:0043277170.011
negative regulation of meiotic cell cycle phase transitionGO:190199430.011
multi organism behaviorGO:0051705620.011
positive regulation of mapk cascadeGO:00434101700.011
nucleoside monophosphate catabolic processGO:0009125590.011
regulation of lymphocyte apoptotic processGO:0070228410.011
b cell activationGO:00421131610.011
metaphase plate congressionGO:005131020.011
regulation of cell morphogenesis involved in differentiationGO:00107691510.010
regulation of rho protein signal transductionGO:0035023710.010
response to endoplasmic reticulum stressGO:0034976530.010
skin developmentGO:00435882200.010
guanosine containing compound metabolic processGO:19010681440.010
meiotic chromosome condensationGO:001003230.010
negative regulation of transferase activityGO:0051348850.010
cellular response to inorganic substanceGO:0071241370.010
regulation of ras protein signal transductionGO:00465781140.010
response to molecule of bacterial originGO:00022371430.010
mitotic centrosome separationGO:000710040.010
regulation of cell migrationGO:00303342190.010
cellular chemical homeostasisGO:00550822150.010
mrna processingGO:0006397630.010
sensory perception of soundGO:0007605970.010
gtp catabolic processGO:00061841430.010
macromolecular complex disassemblyGO:0032984430.010

Pola1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.014
cancerDOID:16200.014
central nervous system diseaseDOID:33100.014
nervous system diseaseDOID:86300.014
disease of anatomical entityDOID:700.014
organ system cancerDOID:005068600.011