IMP: Integrative Multi-species Prediction

Mus musculus

64 known processes

Trpm8

transient receptor potential cation channel, subfamily M, member 8

(Aliases: TRPP8,CMR1,MGC2849,Trp-p8,LTRPC6,LTrpC-6)

Ensembl: ENSMUSG00000036251
Entrez: 171382
UniProtKB: Q8R4D5

Process Predictions
Disease Predictions

Trpm8 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of membrane potential	GO:0042391	192	0.135
regulation of cellular ketone metabolic process	GO:0010565	66	0.080
muscle system process	GO:0003012	141	0.067
macromolecule catabolic process	GO:0009057	281	0.063
negative regulation of cellular component organization	GO:0051129	194	0.063
monocarboxylic acid metabolic process	GO:0032787	191	0.060
amine metabolic process	GO:0009308	45	0.056
axonogenesis	GO:0007409	274	0.055
carbohydrate metabolic process	GO:0005975	230	0.048
regulation of anatomical structure size	GO:0090066	178	0.045
regionalization	GO:0003002	337	0.044
membrane organization	GO:0061024	245	0.042
regulation of system process	GO:0044057	200	0.041
inorganic ion transmembrane transport	GO:0098660	234	0.040
cellular amino acid metabolic process	GO:0006520	103	0.039
peptidyl serine modification	GO:0018209	83	0.039
protein maturation	GO:0051604	176	0.039
negative regulation of cell development	GO:0010721	169	0.036
regulation of epithelial cell proliferation	GO:0050678	141	0.036
urogenital system development	GO:0001655	261	0.036
cellular amine metabolic process	GO:0044106	44	0.036
regulation of cellular amino acid metabolic process	GO:0006521	5	0.034
circulatory system process	GO:0003013	197	0.033
regulation of secretion	GO:0051046	274	0.032
cellular lipid metabolic process	GO:0044255	323	0.032
skin development	GO:0043588	220	0.032
response to peptide	GO:1901652	136	0.032
muscle contraction	GO:0006936	101	0.030
sensory organ morphogenesis	GO:0090596	242	0.030	Mouse
blood circulation	GO:0008015	195	0.030
cellular response to insulin stimulus	GO:0032869	78	0.029
regulation of kinase activity	GO:0043549	249	0.028
gland development	GO:0048732	330	0.028
protein processing	GO:0016485	163	0.028
regulation of cellular amine metabolic process	GO:0033238	20	0.027
cellular response to hormone stimulus	GO:0032870	150	0.027
multicellular organism growth	GO:0035264	161	0.027
mapk cascade	GO:0000165	281	0.027
regulation of cell projection organization	GO:0031344	206	0.027
action potential	GO:0001508	78	0.027
peptidyl amino acid modification	GO:0018193	336	0.026
regulation of neuron differentiation	GO:0045664	281	0.026
regulation of neuron projection development	GO:0010975	169	0.026
positive regulation of cell development	GO:0010720	237	0.026
chemotaxis	GO:0006935	247	0.026	Mouse
cell fate commitment	GO:0045165	210	0.025
regulation of cellular component size	GO:0032535	121	0.025
hematopoietic progenitor cell differentiation	GO:0002244	143	0.024
learning or memory	GO:0007611	148	0.024
small gtpase mediated signal transduction	GO:0007264	97	0.024
transmission of nerve impulse	GO:0019226	76	0.024
transmembrane transport	GO:0055085	412	0.024
digestive system development	GO:0055123	200	0.024
male gamete generation	GO:0048232	285	0.024
inflammatory response	GO:0006954	244	0.024
response to organonitrogen compound	GO:0010243	246	0.024
telencephalon development	GO:0021537	186	0.023
cognition	GO:0050890	149	0.023
kidney development	GO:0001822	213	0.023
fertilization	GO:0009566	127	0.023
multicellular organismal signaling	GO:0035637	91	0.023
cellular response to organonitrogen compound	GO:0071417	145	0.023
oxidation reduction process	GO:0055114	342	0.022
extracellular matrix organization	GO:0030198	147	0.022
cellular ketone metabolic process	GO:0042180	84	0.022
asymmetric stem cell division	GO:0098722	3	0.022
carbohydrate derivative catabolic process	GO:1901136	231	0.022
multi multicellular organism process	GO:0044706	109	0.022
extracellular structure organization	GO:0043062	148	0.022
aromatic compound catabolic process	GO:0019439	286	0.022
response to peptide hormone	GO:0043434	127	0.021
negative regulation of nervous system development	GO:0051961	156	0.021
regulation of cellular response to stress	GO:0080135	159	0.021
steroid metabolic process	GO:0008202	119	0.021
microtubule based process	GO:0007017	236	0.021
nitrogen compound transport	GO:0071705	271	0.021
organonitrogen compound catabolic process	GO:1901565	264	0.021
central nervous system neuron differentiation	GO:0021953	162	0.021
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.021
nucleobase containing small molecule metabolic process	GO:0055086	352	0.021
synapse organization	GO:0050808	125	0.021
cell growth involved in cardiac muscle cell development	GO:0061049	3	0.021
ossification	GO:0001503	216	0.021
pallium development	GO:0021543	120	0.020
physiological cardiac muscle hypertrophy	GO:0003301	3	0.020
endomembrane system organization	GO:0010256	147	0.020
regulation of response to wounding	GO:1903034	189	0.020
forebrain development	GO:0030900	302	0.020
response to radiation	GO:0009314	165	0.020	Mouse
dna metabolic process	GO:0006259	303	0.020
spermatogenesis	GO:0007283	284	0.020
positive regulation of vasoconstriction	GO:0045907	4	0.020
sensory perception	GO:0007600	245	0.020
actin filament organization	GO:0007015	113	0.019
regulation of cell cycle	GO:0051726	281	0.019
heterocycle catabolic process	GO:0046700	280	0.019
positive regulation of cellular amine metabolic process	GO:0033240	5	0.019
regulation of transferase activity	GO:0051338	263	0.019
cation transport	GO:0006812	399	0.019
morphogenesis of embryonic epithelium	GO:0016331	159	0.019
response to nutrient levels	GO:0031667	109	0.019
positive regulation of kinase activity	GO:0033674	155	0.019
cell adhesion	GO:0007155	329	0.019	Mouse
regulation of organelle organization	GO:0033043	289	0.019
cellular ion homeostasis	GO:0006873	165	0.018
leukocyte differentiation	GO:0002521	342	0.018
organic cyclic compound catabolic process	GO:1901361	295	0.018
cellular response to peptide	GO:1901653	92	0.018
regulation of cellular component biogenesis	GO:0044087	181	0.018
negative regulation of cell cycle	GO:0045786	123	0.018
cation transmembrane transport	GO:0098655	266	0.018
regulation of binding	GO:0051098	111	0.018
regulation of blood circulation	GO:1903522	93	0.017
single fertilization	GO:0007338	82	0.017
germ cell development	GO:0007281	185	0.017
response to fibroblast growth factor	GO:0071774	47	0.017
metal ion homeostasis	GO:0055065	189	0.017
respiratory tube development	GO:0030323	167	0.017
regulation of ossification	GO:0030278	112	0.017
synaptic transmission	GO:0007268	329	0.017
apoptotic signaling pathway	GO:0097190	306	0.017
epidermis development	GO:0008544	187	0.017
response to testosterone	GO:0033574	3	0.017
regulation of transporter activity	GO:0032409	57	0.017
negative regulation of neuron projection regeneration	GO:0070571	3	0.017
positive regulation of cell death	GO:0010942	224	0.017
nuclear division	GO:0000280	158	0.017
rhythmic process	GO:0048511	174	0.017
purine nucleotide metabolic process	GO:0006163	302	0.016
regulation of ion transport	GO:0043269	215	0.016
purine containing compound metabolic process	GO:0072521	311	0.016
photoreceptor cell development	GO:0042461	40	0.016	Mouse
cellular response to peptide hormone stimulus	GO:0071375	92	0.016
homeostasis of number of cells	GO:0048872	210	0.016
organic acid catabolic process	GO:0016054	51	0.016
response to extracellular stimulus	GO:0009991	127	0.016
negative regulation of cellular amine metabolic process	GO:0033239	1	0.016
wnt signaling pathway	GO:0016055	188	0.016
reactive oxygen species metabolic process	GO:0072593	84	0.016
protein ubiquitination	GO:0016567	171	0.016
developmental maturation	GO:0021700	193	0.016
regulation of mapk cascade	GO:0043408	248	0.016
insulin receptor signaling pathway	GO:0008286	49	0.016
ribonucleotide metabolic process	GO:0009259	291	0.016
reactive nitrogen species metabolic process	GO:2001057	0	0.016
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.016
mesodermal cell migration	GO:0008078	4	0.015
glycosylation	GO:0070085	62	0.015
purine nucleoside metabolic process	GO:0042278	241	0.015
cellular response to lipid	GO:0071396	145	0.015
small molecule biosynthetic process	GO:0044283	132	0.015
neuronal action potential	GO:0019228	54	0.015
inorganic cation transmembrane transport	GO:0098662	207	0.015
nucleotide metabolic process	GO:0009117	332	0.015
regulation of action potential	GO:0098900	4	0.015
endothelial cell differentiation	GO:0045446	41	0.015
negative regulation of phosphorylation	GO:0042326	166	0.015
posttranscriptional regulation of gene expression	GO:0010608	155	0.015
protein localization to organelle	GO:0033365	185	0.015
negative regulation of cell growth involved in cardiac muscle cell development	GO:0061052	2	0.015
regulation of angiotensin levels in blood	GO:0002002	4	0.015
cell type specific apoptotic process	GO:0097285	268	0.015
organelle fission	GO:0048285	170	0.015
negative regulation of protein metabolic process	GO:0051248	282	0.015
response to insulin	GO:0032868	100	0.015
regulation of ion transmembrane transport	GO:0034765	119	0.015
g protein coupled receptor signaling pathway	GO:0007186	243	0.015
sulfur compound metabolic process	GO:0006790	100	0.015
positive regulation of secretion by cell	GO:1903532	114	0.015
protein modification by small protein conjugation or removal	GO:0070647	207	0.014
somitogenesis	GO:0001756	69	0.014
renal system development	GO:0072001	225	0.014
protein localization to membrane	GO:0072657	108	0.014
cellular nitrogen compound catabolic process	GO:0044270	280	0.014
lipid biosynthetic process	GO:0008610	179	0.014
ribose phosphate metabolic process	GO:0019693	291	0.014
phospholipid metabolic process	GO:0006644	87	0.014
cellular response to external stimulus	GO:0071496	88	0.014
divalent inorganic cation homeostasis	GO:0072507	138	0.014
learning	GO:0007612	98	0.014
regulation of lymphocyte mediated immunity	GO:0002706	84	0.014
regulation of feeding behavior	GO:0060259	3	0.014
organonitrogen compound biosynthetic process	GO:1901566	192	0.014
heart process	GO:0003015	94	0.014
macromolecule glycosylation	GO:0043413	55	0.014
epithelial cell proliferation	GO:0050673	174	0.014
small molecule catabolic process	GO:0044282	71	0.014
positive regulation of secretion	GO:0051047	130	0.014
response to lipopolysaccharide	GO:0032496	128	0.014
development of primary male sexual characteristics	GO:0046546	88	0.014
carbohydrate derivative biosynthetic process	GO:1901137	183	0.014
neuron projection guidance	GO:0097485	141	0.014
physiological muscle hypertrophy	GO:0003298	3	0.014
positive regulation of growth	GO:0045927	104	0.014
cellular response to extracellular stimulus	GO:0031668	81	0.014
positive regulation of protein modification process	GO:0031401	299	0.014
monosaccharide metabolic process	GO:0005996	106	0.014
cytokine production	GO:0001816	319	0.014
purine ribonucleoside metabolic process	GO:0046128	241	0.014
response to acid chemical	GO:0001101	111	0.014
respiratory system development	GO:0060541	190	0.014
nucleotide catabolic process	GO:0009166	217	0.014
mesonephric epithelium development	GO:0072163	94	0.014
regulation of secretion by cell	GO:1903530	249	0.014
cell maturation	GO:0048469	127	0.013
glycoprotein metabolic process	GO:0009100	116	0.013
negative regulation of phosphate metabolic process	GO:0045936	184	0.013
tube formation	GO:0035148	140	0.013
protein glycosylation	GO:0006486	55	0.013
vasodilation	GO:0042311	28	0.013
cellular metal ion homeostasis	GO:0006875	151	0.013
embryonic placenta development	GO:0001892	98	0.013
regulation of vesicle mediated transport	GO:0060627	139	0.013
negative regulation of cellular protein metabolic process	GO:0032269	247	0.013
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.013
negative regulation of neuron projection development	GO:0010977	50	0.013
epithelial tube morphogenesis	GO:0060562	303	0.013
positive regulation of organelle organization	GO:0010638	128	0.013
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.013
positive regulation of nervous system development	GO:0051962	221	0.013
glycoprotein biosynthetic process	GO:0009101	89	0.013
nucleoside triphosphate metabolic process	GO:0009141	230	0.013
oocyte construction	GO:0007308	2	0.012
protein oligomerization	GO:0051259	67	0.012
nucleocytoplasmic transport	GO:0006913	139	0.012
regulation of cell growth	GO:0001558	91	0.012
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.012
purine ribonucleotide metabolic process	GO:0009150	290	0.012
nucleoside phosphate metabolic process	GO:0006753	338	0.012
nucleoside metabolic process	GO:0009116	246	0.012
cellular homeostasis	GO:0019725	240	0.012
stem cell maintenance	GO:0019827	130	0.012
positive regulation of ion transport	GO:0043270	65	0.012
regulation of hormone levels	GO:0010817	211	0.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.012
ribonucleotide catabolic process	GO:0009261	208	0.012
regulation of cell growth involved in cardiac muscle cell development	GO:0061050	3	0.012
positive regulation of transferase activity	GO:0051347	167	0.012
regulation of cell cycle process	GO:0010564	160	0.012
stem cell proliferation	GO:0072089	117	0.012
glycosyl compound metabolic process	GO:1901657	246	0.012
cellular macromolecule catabolic process	GO:0044265	206	0.012
ear development	GO:0043583	200	0.012
organic hydroxy compound metabolic process	GO:1901615	203	0.012
limb morphogenesis	GO:0035108	149	0.012
neurological system process involved in regulation of systemic arterial blood pressure	GO:0001976	18	0.012
negative regulation of organelle organization	GO:0010639	90	0.012
positive regulation of apoptotic process	GO:0043065	217	0.012
negative regulation of molecular function	GO:0044092	258	0.012
meiotic nuclear division	GO:0007126	115	0.012
protein catabolic process	GO:0030163	221	0.012
glycerolipid metabolic process	GO:0046486	122	0.012
interleukin 8 production	GO:0032637	4	0.012
regulation of protein kinase activity	GO:0045859	232	0.012
regulation of protein processing	GO:0070613	96	0.012
circadian rhythm	GO:0007623	114	0.011
amide transport	GO:0042886	138	0.011
mitotic cell cycle	GO:0000278	195	0.011
response to monosaccharide	GO:0034284	67	0.011
cytoplasmic transport	GO:0016482	234	0.011
appendage morphogenesis	GO:0035107	149	0.011
zymogen activation	GO:0031638	41	0.011
anatomical structure homeostasis	GO:0060249	145	0.011
regulation of systemic arterial blood pressure	GO:0003073	61	0.011
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.011
negative regulation of protein modification process	GO:0031400	163	0.011
response to molecule of bacterial origin	GO:0002237	143	0.011
protein modification by small protein conjugation	GO:0032446	187	0.011
retina development in camera type eye	GO:0060041	119	0.011
organelle assembly	GO:0070925	177	0.011
regulation of body fluid levels	GO:0050878	162	0.011
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.011
response to inorganic substance	GO:0010035	96	0.011
dna recombination	GO:0006310	92	0.011
positive regulation of protein phosphorylation	GO:0001934	242	0.011
t cell differentiation	GO:0030217	174	0.011
potassium ion transmembrane transport	GO:0071805	43	0.011	Mouse
memory	GO:0007613	58	0.011
regulation of protein localization	GO:0032880	231	0.011
positive regulation of binding	GO:0051099	49	0.011
axon guidance	GO:0007411	141	0.011
ion transmembrane transport	GO:0034220	361	0.011
cilium assembly	GO:0042384	81	0.011
organophosphate catabolic process	GO:0046434	232	0.011
sensory perception of sound	GO:0007605	97	0.011
negative regulation of response to wounding	GO:1903035	77	0.011
epithelial cell development	GO:0002064	159	0.011
regulation of neurotransmitter levels	GO:0001505	87	0.011
ribonucleoside metabolic process	GO:0009119	245	0.011
detection of stimulus	GO:0051606	84	0.011
leukocyte mediated immunity	GO:0002443	174	0.011
regulation of cytokine production	GO:0001817	266	0.011
oocyte axis specification	GO:0007309	2	0.011
glucose homeostasis	GO:0042593	128	0.011
sperm egg recognition	GO:0035036	37	0.010
male sex differentiation	GO:0046661	109	0.010
heart morphogenesis	GO:0003007	178	0.010
regulation of lipid metabolic process	GO:0019216	118	0.010
protein targeting	GO:0006605	143	0.010
cellular protein complex assembly	GO:0043623	116	0.010
binding of sperm to zona pellucida	GO:0007339	34	0.010
kidney mesenchyme morphogenesis	GO:0072131	4	0.010
regulation of metal ion transport	GO:0010959	106	0.010
carboxylic acid biosynthetic process	GO:0046394	86	0.010
negative regulation of phosphorus metabolic process	GO:0010563	184	0.010
single organism cell adhesion	GO:0098602	156	0.010
regulation of blood pressure	GO:0008217	93	0.010
negative regulation of cytokine production	GO:0001818	84	0.010
potassium ion transport	GO:0006813	52	0.010	Mouse
regulation of cell size	GO:0008361	72	0.010
organic acid biosynthetic process	GO:0016053	86	0.010
carbohydrate biosynthetic process	GO:0016051	74	0.010
negative regulation of multi organism process	GO:0043901	68	0.010

Trpm8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.016
disease of anatomical entity	DOID:7	0.016
disease of metabolism	DOID:0014667	0.014
disease of cellular proliferation	DOID:14566	0.011
musculoskeletal system disease	DOID:17	0.010

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