IMP: Integrative Multi-species Prediction

Mus musculus

50 known processes

Trpm7

transient receptor potential cation channel, subfamily M, member 7

(Aliases: 4833414K03Rik,Ltpr7,CHAK,TRPPLIK,Ltrpc7,CHAK1,2310022G15Rik,LTrpC-7,5033407O22Rik)

Ensembl: ENSMUSG00000027365
Entrez: 58800
UniProtKB: Q923J1
UniProtKB: A2AI57

Process Predictions
Disease Predictions

Trpm7 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of cell cycle	GO:0051726	281	0.288	Zebrafish
modification dependent protein catabolic process	GO:0019941	133	0.208
organic cyclic compound catabolic process	GO:1901361	295	0.203
cation homeostasis	GO:0055080	212	0.155	Zebrafish Mouse Rat Fly
cellular nitrogen compound catabolic process	GO:0044270	280	0.148
hematopoietic progenitor cell differentiation	GO:0002244	143	0.133
cellular chemical homeostasis	GO:0055082	215	0.131	Mouse Rat
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.127
ion transmembrane transport	GO:0034220	361	0.123
modification dependent macromolecule catabolic process	GO:0043632	133	0.116
protein catabolic process	GO:0030163	221	0.114
cellular metal ion homeostasis	GO:0006875	151	0.110	Mouse Rat
protein modification by small protein conjugation	GO:0032446	187	0.108
atp catabolic process	GO:0006200	55	0.105
embryonic epithelial tube formation	GO:0001838	130	0.101
nucleoside monophosphate metabolic process	GO:0009123	85	0.100
cell division	GO:0051301	120	0.099
neural tube formation	GO:0001841	108	0.094
purine nucleotide metabolic process	GO:0006163	302	0.087
cellular homeostasis	GO:0019725	240	0.085	Mouse Rat
gonad development	GO:0008406	141	0.084	Worm
macromolecule catabolic process	GO:0009057	281	0.084
mitotic cell cycle	GO:0000278	195	0.075	Zebrafish Worm
inorganic ion transmembrane transport	GO:0098660	234	0.075
inorganic cation transmembrane transport	GO:0098662	207	0.074
metencephalon development	GO:0022037	89	0.072
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.071
chromatin organization	GO:0006325	206	0.070
regulation of cellular ketone metabolic process	GO:0010565	66	0.069
ubiquitin dependent protein catabolic process	GO:0006511	129	0.069
histone modification	GO:0016570	159	0.062
regulation of ion transport	GO:0043269	215	0.062
cellular ketone metabolic process	GO:0042180	84	0.062
purine ribonucleoside metabolic process	GO:0046128	241	0.062
cellular amino acid metabolic process	GO:0006520	103	0.062
regulation of organelle organization	GO:0033043	289	0.061
calcium ion homeostasis	GO:0055074	127	0.059	Mouse
cation transport	GO:0006812	399	0.059
actin filament based movement	GO:0030048	23	0.059
regulation of cell cycle process	GO:0010564	160	0.059
atp metabolic process	GO:0046034	75	0.058
aromatic compound catabolic process	GO:0019439	286	0.056
cation transmembrane transport	GO:0098655	266	0.055
glycosyl compound metabolic process	GO:1901657	246	0.055
cellular response to dna damage stimulus	GO:0006974	207	0.055
glycoprotein metabolic process	GO:0009100	116	0.055
chromatin modification	GO:0016568	187	0.053
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.053
divalent inorganic cation homeostasis	GO:0072507	138	0.052	Zebrafish Mouse Rat Fly
angiogenesis	GO:0001525	201	0.051
purine ribonucleotide metabolic process	GO:0009150	290	0.050
calcium ion transport	GO:0006816	159	0.050
multicellular organism growth	GO:0035264	161	0.050
amine metabolic process	GO:0009308	45	0.049
cellular protein catabolic process	GO:0044257	155	0.049
organophosphate catabolic process	GO:0046434	232	0.047
cellular amine metabolic process	GO:0044106	44	0.045
nucleoside catabolic process	GO:0009164	206	0.045
regulation of mitotic cell cycle	GO:0007346	126	0.042	Zebrafish
covalent chromatin modification	GO:0016569	163	0.042
primary neural tube formation	GO:0014020	95	0.041
blood circulation	GO:0008015	195	0.041	Zebrafish
oxidation reduction process	GO:0055114	342	0.041
forebrain development	GO:0030900	302	0.041
positive regulation of cellular catabolic process	GO:0031331	148	0.041
purine nucleoside monophosphate catabolic process	GO:0009128	58	0.040
maintenance of location	GO:0051235	89	0.039
nucleoside monophosphate catabolic process	GO:0009125	59	0.039
purine ribonucleoside monophosphate catabolic process	GO:0009169	57	0.039
wound healing	GO:0042060	157	0.039
regulation of mesenchymal cell proliferation involved in lung development	GO:2000790	2	0.039
cellular macromolecule catabolic process	GO:0044265	206	0.039
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.038
response to lipopolysaccharide	GO:0032496	128	0.038
hindbrain development	GO:0030902	128	0.036
metal ion homeostasis	GO:0055065	189	0.036	Mouse Rat Fly
myeloid cell differentiation	GO:0030099	233	0.034
purine nucleoside catabolic process	GO:0006152	205	0.034
response to inorganic substance	GO:0010035	96	0.034
tube formation	GO:0035148	140	0.034
meiotic cell cycle	GO:0051321	122	0.034
striated muscle tissue development	GO:0014706	293	0.033
heterocycle catabolic process	GO:0046700	280	0.033
negative regulation of mitotic cell cycle phase transition	GO:1901991	45	0.033
organic anion transport	GO:0015711	137	0.032
purine nucleotide catabolic process	GO:0006195	211	0.032
rna processing	GO:0006396	105	0.032
organelle localization	GO:0051640	179	0.032
epithelial tube formation	GO:0072175	130	0.031
organelle fission	GO:0048285	170	0.030	Worm
regulation of chromatin silencing	GO:0031935	2	0.030
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	40	0.030
negative regulation of cell cycle	GO:0045786	123	0.029
nuclear division	GO:0000280	158	0.029	Worm
carbohydrate derivative biosynthetic process	GO:1901137	183	0.029
purine containing compound metabolic process	GO:0072521	311	0.029
organic hydroxy compound metabolic process	GO:1901615	203	0.029	Zebrafish
compound eye development	GO:0048749	1	0.029
nucleoside triphosphate catabolic process	GO:0009143	205	0.028
posttranscriptional regulation of gene expression	GO:0010608	155	0.028
regulation of embryonic development	GO:0045995	71	0.028
purine nucleoside metabolic process	GO:0042278	241	0.028
ribonucleotide catabolic process	GO:0009261	208	0.028
tube closure	GO:0060606	91	0.028
negative regulation of cell cycle phase transition	GO:1901988	48	0.027
cellular response to lipid	GO:0071396	145	0.026
purine containing compound catabolic process	GO:0072523	213	0.026
regulation of ion transmembrane transport	GO:0034765	119	0.026
ribonucleoside monophosphate catabolic process	GO:0009158	57	0.026
cell cycle g1 s phase transition	GO:0044843	57	0.026
ribonucleotide metabolic process	GO:0009259	291	0.026
protein modification by small protein conjugation or removal	GO:0070647	207	0.026
intracellular protein transport	GO:0006886	204	0.026
regulation of cell cycle phase transition	GO:1901987	77	0.026
carbohydrate derivative catabolic process	GO:1901136	231	0.026
lateral inhibition	GO:0046331	1	0.025
myotube differentiation	GO:0014902	105	0.025
neural tube closure	GO:0001843	90	0.025
negative regulation of protein metabolic process	GO:0051248	282	0.025
gland development	GO:0048732	330	0.025
positive regulation of endocytosis	GO:0045807	42	0.025
nucleoside phosphate catabolic process	GO:1901292	222	0.025
retina development in camera type eye	GO:0060041	119	0.025
transmembrane transport	GO:0055085	412	0.024
mitotic nuclear division	GO:0007067	48	0.024	Worm
ribonucleoside metabolic process	GO:0009119	245	0.024
nucleoside phosphate metabolic process	GO:0006753	338	0.024
regulation of cell activation	GO:0050865	289	0.024
epidermis development	GO:0008544	187	0.024
positive regulation of hydrolase activity	GO:0051345	148	0.024
positive regulation of proteolysis	GO:0045862	85	0.024
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.024
camera type eye development	GO:0043010	266	0.023
nucleotide catabolic process	GO:0009166	217	0.023
regulation of cellular catabolic process	GO:0031329	242	0.023
multi multicellular organism process	GO:0044706	109	0.023
protein maturation	GO:0051604	176	0.023
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.023
response to radiation	GO:0009314	165	0.023	Mouse Rat
nucleoside triphosphate metabolic process	GO:0009141	230	0.022
sensory organ morphogenesis	GO:0090596	242	0.022	Mouse
gene silencing	GO:0016458	38	0.022
muscle contraction	GO:0006936	101	0.022
positive regulation of organelle organization	GO:0010638	128	0.022
cell type specific apoptotic process	GO:0097285	268	0.022
oocyte axis specification	GO:0007309	2	0.022
regulation of homeostatic process	GO:0032844	182	0.022
regulation of metal ion transport	GO:0010959	106	0.022
regulation of cellular amino acid metabolic process	GO:0006521	5	0.022
spermatogenesis	GO:0007283	284	0.022
microtubule cytoskeleton organization	GO:0000226	157	0.022
negative regulation of protein modification process	GO:0031400	163	0.021
response to arsenic containing substance	GO:0046685	5	0.021
regulation of translation	GO:0006417	71	0.021
purine ribonucleotide catabolic process	GO:0009154	208	0.021
regulation of neuron differentiation	GO:0045664	281	0.021
genitalia development	GO:0048806	37	0.021	Worm
regionalization	GO:0003002	337	0.021
homeostasis of number of cells	GO:0048872	210	0.021
nucleobase containing small molecule metabolic process	GO:0055086	352	0.021
negative regulation of cellular protein metabolic process	GO:0032269	247	0.021
regulation of intracellular transport	GO:0032386	159	0.021
myeloid leukocyte differentiation	GO:0002573	119	0.021
negative regulation of phosphorus metabolic process	GO:0010563	184	0.021
axonogenesis	GO:0007409	274	0.021
organelle assembly	GO:0070925	177	0.020
purine ribonucleoside catabolic process	GO:0046130	205	0.020
neurotransmitter secretion	GO:0007269	62	0.020	Zebrafish
proteasomal protein catabolic process	GO:0010498	98	0.020
actin mediated cell contraction	GO:0070252	15	0.020
nucleotide metabolic process	GO:0009117	332	0.020
muscle cell differentiation	GO:0042692	261	0.020
positive regulation of myeloid cell apoptotic process	GO:0033034	4	0.020
negative regulation of molecular function	GO:0044092	258	0.020
peptidyl amino acid modification	GO:0018193	336	0.020
cellular response to hormone stimulus	GO:0032870	150	0.020
stem cell maintenance	GO:0019827	130	0.019
muscle system process	GO:0003012	141	0.019
cochlear nucleus development	GO:0021747	4	0.019
positive regulation of cell cycle process	GO:0090068	61	0.019
regulation of transmembrane transport	GO:0034762	128	0.019
inner ear receptor cell differentiation	GO:0060113	61	0.019
cellular response to insulin stimulus	GO:0032869	78	0.019
sodium ion transport	GO:0006814	73	0.019	Mouse
divalent inorganic cation transport	GO:0072511	178	0.019
neural tube development	GO:0021915	160	0.019
regulation of proteolysis	GO:0030162	164	0.019
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.019
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.019
protein processing	GO:0016485	163	0.018
negative regulation of cellular amine metabolic process	GO:0033239	1	0.018
microtubule anchoring at microtubule organizing center	GO:0072393	5	0.018
response to testosterone	GO:0033574	3	0.018
small gtpase mediated signal transduction	GO:0007264	97	0.018
cellular ion homeostasis	GO:0006873	165	0.018	Mouse Rat
ear development	GO:0043583	200	0.018
protein localization to organelle	GO:0033365	185	0.018
regulation of protein localization	GO:0032880	231	0.018
t cell activation	GO:0042110	289	0.018
phagocytosis	GO:0006909	66	0.018
leukocyte proliferation	GO:0070661	172	0.018
organonitrogen compound catabolic process	GO:1901565	264	0.018
regulation of membrane potential	GO:0042391	192	0.018
cardiocyte differentiation	GO:0035051	87	0.018
protein polymerization	GO:0051258	57	0.018
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.017
translation	GO:0006412	93	0.017
muscle tissue development	GO:0060537	308	0.017
development of primary sexual characteristics	GO:0045137	143	0.017	Worm
protein oligomerization	GO:0051259	67	0.017	Mouse
apoptotic signaling pathway	GO:0097190	306	0.017
negative regulation of cell proliferation	GO:0008285	296	0.017
positive regulation of cellular amine metabolic process	GO:0033240	5	0.017
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.017	Mouse Rat
blastocyst development	GO:0001824	80	0.017
interkinetic nuclear migration	GO:0022027	8	0.017
neural nucleus development	GO:0048857	22	0.017
female gamete generation	GO:0007292	74	0.017
potassium ion transport	GO:0006813	52	0.016	Mouse
negative regulation of protein processing	GO:0010955	79	0.016
response to uv	GO:0009411	44	0.016
meiotic nuclear division	GO:0007126	115	0.016
establishment of organelle localization	GO:0051656	122	0.016
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.016
cell aging	GO:0007569	35	0.016
ribose phosphate metabolic process	GO:0019693	291	0.016
synaptic transmission	GO:0007268	329	0.015	Zebrafish
lipid localization	GO:0010876	126	0.015
response to molecule of bacterial origin	GO:0002237	143	0.015
negative regulation of mesenchymal cell proliferation	GO:0072201	3	0.015
lymphocyte differentiation	GO:0030098	242	0.015
germ cell development	GO:0007281	185	0.015
regulation of cytokine production	GO:0001817	266	0.015
bone development	GO:0060348	120	0.015
regulation of apoptotic signaling pathway	GO:2001233	197	0.014
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.014
chemotaxis	GO:0006935	247	0.014	Mouse
action potential	GO:0001508	78	0.014
monovalent inorganic cation homeostasis	GO:0055067	33	0.014
regulation of calcium ion transport into cytosol	GO:0010522	31	0.014
morphogenesis of embryonic epithelium	GO:0016331	159	0.014
regulation of protein maturation	GO:1903317	96	0.014
regulation of protein transport	GO:0051223	163	0.014
auditory receptor cell differentiation	GO:0042491	37	0.014
response to light stimulus	GO:0009416	135	0.014	Mouse
ribonucleoside catabolic process	GO:0042454	206	0.014
negative regulation of protein maturation	GO:1903318	79	0.014
neuronal action potential	GO:0019228	54	0.014
cellular response to organonitrogen compound	GO:0071417	145	0.014
cytokine production	GO:0001816	319	0.014
nitrogen compound transport	GO:0071705	271	0.013
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.013
ossification	GO:0001503	216	0.013	Zebrafish
negative regulation of mitotic cell cycle	GO:0045930	58	0.013
regulation of ketone biosynthetic process	GO:0010566	2	0.013
monocyte differentiation	GO:0030224	9	0.013
anion transport	GO:0006820	177	0.013
megakaryocyte differentiation	GO:0030219	26	0.013
peptidyl serine phosphorylation	GO:0018105	74	0.013
neuron migration	GO:0001764	122	0.013
adaptive immune response	GO:0002250	155	0.013
circulatory system process	GO:0003013	197	0.013	Zebrafish
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.013
positive regulation of protein phosphorylation	GO:0001934	242	0.013
protein ubiquitination	GO:0016567	171	0.013
developmental growth involved in morphogenesis	GO:0060560	138	0.013
steroid metabolic process	GO:0008202	119	0.013
regulation of cytoplasmic transport	GO:1903649	112	0.013
leukocyte differentiation	GO:0002521	342	0.013
negative regulation of phosphate metabolic process	GO:0045936	184	0.012
cardiac muscle tissue development	GO:0048738	130	0.012
cellular response to steroid hormone stimulus	GO:0071383	33	0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.012
negative regulation of protein phosphorylation	GO:0001933	126	0.012
skin development	GO:0043588	220	0.012
regulation of protein processing	GO:0070613	96	0.012
nucleus localization	GO:0051647	20	0.012
skeletal system development	GO:0001501	356	0.012	Zebrafish
regulation of stem cell proliferation	GO:0072091	78	0.012
cellular response to abiotic stimulus	GO:0071214	56	0.012	Mouse
dna metabolic process	GO:0006259	303	0.012
pharynx development	GO:0060465	1	0.012
cellular response to lipopolysaccharide	GO:0071222	77	0.012
vacuole organization	GO:0007033	38	0.012
meiotic cell cycle process	GO:1903046	77	0.012
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.012
nucleoside metabolic process	GO:0009116	246	0.012
central nervous system neuron differentiation	GO:0021953	162	0.012
retina morphogenesis in camera type eye	GO:0060042	45	0.012
learning or memory	GO:0007611	148	0.012	Rat
extrinsic apoptotic signaling pathway	GO:0097191	126	0.012
negative regulation of translation	GO:0017148	22	0.012
response to growth factor	GO:0070848	198	0.012
rna interference	GO:0016246	2	0.011
cytoplasmic transport	GO:0016482	234	0.011
defense response to other organism	GO:0098542	197	0.011
regulation of protein ubiquitination	GO:0031396	52	0.011
regulation of cellular response to stress	GO:0080135	159	0.011
oocyte construction	GO:0007308	2	0.011
signal transduction by p53 class mediator	GO:0072331	51	0.011
cellular protein complex assembly	GO:0043623	116	0.011
regulation of establishment of protein localization	GO:0070201	181	0.011
endocytosis	GO:0006897	168	0.011
mitotic cell cycle process	GO:1903047	159	0.011	Worm
positive regulation of protein modification process	GO:0031401	299	0.011
cellularization	GO:0007349	1	0.011
ras protein signal transduction	GO:0007265	77	0.011
mrna metabolic process	GO:0016071	84	0.011
respiratory system development	GO:0060541	190	0.011
granulocyte differentiation	GO:0030851	17	0.011
intrinsic apoptotic signaling pathway	GO:0097193	132	0.011
hydrogen ion transmembrane transport	GO:1902600	25	0.011
glycoprotein biosynthetic process	GO:0009101	89	0.011
cell adhesion	GO:0007155	329	0.011
endoderm development	GO:0007492	45	0.011
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.011
nuclear import	GO:0051170	95	0.011
regulation of intracellular protein transport	GO:0033157	82	0.011
glycosyl compound catabolic process	GO:1901658	206	0.011
bone morphogenesis	GO:0060349	78	0.011
cell proliferation in forebrain	GO:0021846	30	0.010
establishment of rna localization	GO:0051236	18	0.010
regulation of isoprenoid metabolic process	GO:0019747	1	0.010
carboxylic acid biosynthetic process	GO:0046394	86	0.010
nucleocytoplasmic transport	GO:0006913	139	0.010
regulation of protein catabolic process	GO:0042176	108	0.010
positive regulation of ion transport	GO:0043270	65	0.010
skeletal system morphogenesis	GO:0048705	203	0.010
regulation of neurotransmitter levels	GO:0001505	87	0.010	Zebrafish
positive regulation of homeostatic process	GO:0032846	64	0.010
blood vessel morphogenesis	GO:0048514	285	0.010
regulation of lymphocyte activation	GO:0051249	240	0.010
negative regulation of cell cycle process	GO:0010948	69	0.010
histone lysine demethylation	GO:0070076	13	0.010
positive regulation of fatty acid biosynthetic process	GO:0045723	3	0.010

Trpm7 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.101
glomerulosclerosis	DOID:0050851	0.101
nephritis	DOID:10952	0.101
glomerulonephritis	DOID:2921	0.101
focal segmental glomerulosclerosis	DOID:1312	0.101
kidney disease	DOID:557	0.101
urinary system disease	DOID:18	0.101
nervous system disease	DOID:863	0.066
sensory system disease	DOID:0050155	0.040
organ system cancer	DOID:0050686	0.032
cancer	DOID:162	0.032
disease of cellular proliferation	DOID:14566	0.032
endocrine gland cancer	DOID:170	0.017

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