IMP: Integrative Multi-species Prediction

Mus musculus

82 known processes

Jag2

jagged 2

(Aliases: sm,D12Ggc2e,Serh,mJagged2-1)

Ensembl: ENSMUSG00000002799
Entrez: 16450
UniProtKB: Q9QYE5

Process Predictions
Disease Predictions

Jag2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of neuron projection development	GO:0010975	169	0.971
regulation of neuron differentiation	GO:0045664	281	0.927	Mouse
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.911
compartment pattern specification	GO:0007386	4	0.908	Mouse
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.886
cardiac right atrium morphogenesis	GO:0003213	3	0.856
synapse organization	GO:0050808	125	0.842
embryonic organ morphogenesis	GO:0048562	276	0.809	Mouse
microtubule based process	GO:0007017	236	0.805
spermatogenesis	GO:0007283	284	0.793	Human Rat
appendage development	GO:0048736	166	0.784	Fly
somite specification	GO:0001757	4	0.772	Mouse
muscle tissue development	GO:0060537	308	0.764	Mouse
positive regulation of cell development	GO:0010720	237	0.724
camera type eye development	GO:0043010	266	0.713	Mouse
axonogenesis	GO:0007409	274	0.677
mitotic cell cycle	GO:0000278	195	0.668	Fly
angiogenesis	GO:0001525	201	0.663	Mouse
appendage morphogenesis	GO:0035107	149	0.628	Fly
skeletal system development	GO:0001501	356	0.615
compound eye development	GO:0048749	1	0.605	Fly
negative regulation of neuron differentiation	GO:0045665	101	0.600	Mouse
myotube cell development	GO:0014904	60	0.586
regulation of cardiac cell fate specification	GO:2000043	1	0.549
negative regulation of endothelial cell migration	GO:0010596	4	0.549	Mouse
regulation of somitogenesis	GO:0014807	6	0.543
developmental maturation	GO:0021700	193	0.537
organelle fission	GO:0048285	170	0.536
negative regulation of neuron projection development	GO:0010977	50	0.535
ossification	GO:0001503	216	0.531	Mouse
nuclear division	GO:0000280	158	0.508
positive regulation of neuron projection development	GO:0010976	79	0.494
protein ubiquitination	GO:0016567	171	0.484
limb development	GO:0060173	166	0.478
ameboidal type cell migration	GO:0001667	128	0.476	Mouse
male gamete generation	GO:0048232	285	0.459	Human Rat
negative regulation of cell development	GO:0010721	169	0.459	Mouse
lymphocyte differentiation	GO:0030098	242	0.458
digestive tract morphogenesis	GO:0048546	147	0.456
mapk cascade	GO:0000165	281	0.449
regionalization	GO:0003002	337	0.438	Mouse Fly
meiotic cell cycle	GO:0051321	122	0.437
muscle system process	GO:0003012	141	0.429
blood vessel morphogenesis	GO:0048514	285	0.429	Mouse
skeletal muscle fiber development	GO:0048741	58	0.424
regulation of extracellular matrix assembly	GO:1901201	2	0.423
regulation of cell cycle process	GO:0010564	160	0.422
development of primary sexual characteristics	GO:0045137	143	0.419	Rat
positive regulation of cell migration	GO:0030335	109	0.419
positive regulation of cell cycle	GO:0045787	92	0.418
planar cell polarity pathway involved in pericardium morphogenesis	GO:0061354	2	0.417
dendrite development	GO:0016358	115	0.416
macromolecule catabolic process	GO:0009057	281	0.410
telencephalon development	GO:0021537	186	0.410
negative regulation of fat cell differentiation	GO:0045599	36	0.404	Mouse
regulation of cell cycle	GO:0051726	281	0.402
mitotic cell cycle process	GO:1903047	159	0.398
positive regulation of cellular catabolic process	GO:0031331	148	0.396
neuron projection guidance	GO:0097485	141	0.390
cell adhesion	GO:0007155	329	0.378
regulation of anatomical structure size	GO:0090066	178	0.376
organelle localization	GO:0051640	179	0.367
actin cytoskeleton organization	GO:0030036	220	0.366
negative regulation of blood vessel endothelial cell migration	GO:0043537	3	0.366	Mouse
cell division	GO:0051301	120	0.360
microtubule cytoskeleton organization	GO:0000226	157	0.352
stem cell differentiation	GO:0048863	268	0.342	Mouse Fly
regulation of cell motility	GO:2000145	236	0.340	Mouse
branching morphogenesis of an epithelial tube	GO:0048754	159	0.338	Mouse
wnt signaling pathway involved in forebrain neuroblast division	GO:0021874	2	0.338
negative regulation of growth	GO:0045926	99	0.336
somitogenesis	GO:0001756	69	0.336	Mouse
heart morphogenesis	GO:0003007	178	0.331	Mouse
cell migration involved in endocardial cushion formation	GO:0003273	3	0.329
epidermis development	GO:0008544	187	0.316
negative regulation of cell proliferation	GO:0008285	296	0.306
regulation of cellular catabolic process	GO:0031329	242	0.304
regulation of epithelial cell migration	GO:0010632	35	0.301	Mouse
protein catabolic process	GO:0030163	221	0.300
regulation of organelle organization	GO:0033043	289	0.298
germ cell development	GO:0007281	185	0.295
regulation of cell adhesion	GO:0030155	154	0.294
forebrain development	GO:0030900	302	0.294
positive regulation of neural precursor cell proliferation	GO:2000179	42	0.293	Mouse
positive regulation of mitotic cell cycle	GO:0045931	41	0.292
developmental cell growth	GO:0048588	84	0.289
muscle fiber development	GO:0048747	76	0.282
epithelium migration	GO:0090132	63	0.281	Mouse
protein localization to plasma membrane	GO:0072659	57	0.280
protein localization to membrane	GO:0072657	108	0.277
cell type specific apoptotic process	GO:0097285	268	0.275
regulation of system process	GO:0044057	200	0.271
regulation of cellular component biogenesis	GO:0044087	181	0.269
kidney development	GO:0001822	213	0.269	Zebrafish Mouse
response to molecule of bacterial origin	GO:0002237	143	0.268
negative regulation of glial cell proliferation	GO:0060253	4	0.267
regulation of cell projection organization	GO:0031344	206	0.266
embryonic limb morphogenesis	GO:0030326	126	0.265
cellular response to fibroblast growth factor stimulus	GO:0044344	47	0.263
lateral inhibition	GO:0046331	1	0.263	Fly
negative regulation of epidermal cell differentiation	GO:0045605	7	0.263	Mouse
connective tissue development	GO:0061448	179	0.262
ras protein signal transduction	GO:0007265	77	0.262
central nervous system neuron differentiation	GO:0021953	162	0.262	Zebrafish
regulation of cell size	GO:0008361	72	0.260
neural precursor cell proliferation	GO:0061351	121	0.259	Mouse
asymmetric stem cell division	GO:0098722	3	0.258
cilium morphogenesis	GO:0060271	102	0.256
positive regulation of cell motility	GO:2000147	116	0.253
skin development	GO:0043588	220	0.253
establishment of protein localization to organelle	GO:0072594	118	0.252
meiotic nuclear division	GO:0007126	115	0.249
axon guidance	GO:0007411	141	0.249
oogenesis	GO:0048477	56	0.243
skeletal muscle organ development	GO:0060538	163	0.242
prostate gland epithelium morphogenesis	GO:0060740	31	0.241
positive regulation of cell activation	GO:0050867	158	0.240
skeletal system morphogenesis	GO:0048705	203	0.240
loop of henle development	GO:0072070	10	0.239	Mouse
epithalamus development	GO:0021538	2	0.239
neuroblast fate determination	GO:0007400	1	0.239
telencephalon cell migration	GO:0022029	55	0.238
odontogenesis	GO:0042476	78	0.233
gland development	GO:0048732	330	0.233	Zebrafish Fly
positive regulation of neuroblast proliferation	GO:0002052	19	0.233
muscle contraction	GO:0006936	101	0.229
respiratory system development	GO:0060541	190	0.227
positive regulation of hydrolase activity	GO:0051345	148	0.225
determination of heart left right asymmetry	GO:0061371	48	0.224	Mouse
rhombomere formation	GO:0021594	1	0.223
digestive tract development	GO:0048565	190	0.219
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.218
cellular chemical homeostasis	GO:0055082	215	0.217
cognition	GO:0050890	149	0.215
cartilage development	GO:0051216	140	0.215
gonad development	GO:0008406	141	0.215	Rat
neurotransmitter secretion	GO:0007269	62	0.214
regulation of secretion by cell	GO:1903530	249	0.214
neuron projection extension	GO:1990138	64	0.213
neuron migration	GO:0001764	122	0.213
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.211
positive regulation of cell cycle g1 s phase transition	GO:1902808	9	0.211
segmentation	GO:0035282	93	0.208	Mouse Fly
regulation of secretion	GO:0051046	274	0.204
myoblast differentiation involved in skeletal muscle regeneration	GO:0014835	3	0.204
regulation of pro b cell differentiation	GO:2000973	5	0.204
exocytosis	GO:0006887	121	0.203
striated muscle tissue development	GO:0014706	293	0.203	Mouse
protein modification by small protein conjugation	GO:0032446	187	0.202
limb morphogenesis	GO:0035108	149	0.202
dorsal aorta morphogenesis	GO:0035912	5	0.202	Mouse
blood vessel lumenization	GO:0072554	2	0.201	Mouse
positive regulation of apoptotic process	GO:0043065	217	0.201
leukocyte differentiation	GO:0002521	342	0.198
sensory organ morphogenesis	GO:0090596	242	0.198	Mouse Fly
embryonic skeletal system development	GO:0048706	120	0.196	Mouse
regulation of cellular ketone metabolic process	GO:0010565	66	0.195
negative regulation of nervous system development	GO:0051961	156	0.194	Mouse
endomembrane system organization	GO:0010256	147	0.194
negative regulation of cellular component organization	GO:0051129	194	0.194
developmental growth involved in morphogenesis	GO:0060560	138	0.194
regulation of cell substrate adhesion	GO:0010810	73	0.193
regulation of cell migration	GO:0030334	219	0.193	Mouse
establishment of organelle localization	GO:0051656	122	0.189
negative regulation of cell projection organization	GO:0031345	56	0.188
positive regulation of cell projection organization	GO:0031346	95	0.188
cellular amino acid metabolic process	GO:0006520	103	0.187
membrane organization	GO:0061024	245	0.186
epithelial cell migration	GO:0010631	63	0.185	Mouse
positive regulation of programmed cell death	GO:0043068	218	0.185
cellular response to growth factor stimulus	GO:0071363	197	0.184
planar cell polarity pathway involved in ventricular septum morphogenesis	GO:0061348	2	0.183
cation transport	GO:0006812	399	0.183
regulation of chemotaxis	GO:0050920	53	0.182
glycosyl compound metabolic process	GO:1901657	246	0.181
t cell differentiation	GO:0030217	174	0.180
blood vessel remodeling	GO:0001974	33	0.177	Mouse
epithelial tube morphogenesis	GO:0060562	303	0.177	Mouse
regulation of endothelial cell migration	GO:0010594	22	0.175	Mouse
negative regulation of axon extension	GO:0030517	19	0.174
regulation of ossification	GO:0030278	112	0.174	Mouse
positive regulation of neuron differentiation	GO:0045666	141	0.173
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis	GO:0061350	2	0.173
asymmetric neuroblast division	GO:0055059	1	0.173
negative regulation of molecular function	GO:0044092	258	0.171
endocytosis	GO:0006897	168	0.168
morphogenesis of embryonic epithelium	GO:0016331	159	0.166
glomerular mesangial cell development	GO:0072144	3	0.164
sensory perception	GO:0007600	245	0.162
regulation of extent of cell growth	GO:0061387	52	0.162
neural tube development	GO:0021915	160	0.161
determination of left right symmetry	GO:0007368	80	0.158	Mouse
regulation of neural precursor cell proliferation	GO:2000177	70	0.156	Mouse
negative regulation of photoreceptor cell differentiation	GO:0046533	4	0.155
glomerular mesangial cell differentiation	GO:0072008	3	0.154
regulation of axon extension	GO:0030516	43	0.154
cellular response to hormone stimulus	GO:0032870	150	0.153
neural tube formation	GO:0001841	108	0.153
regulation of embryonic development	GO:0045995	71	0.151
regulation of kinase activity	GO:0043549	249	0.150
cell cell adhesion via plasma membrane adhesion molecules	GO:0098742	40	0.150
retina development in camera type eye	GO:0060041	119	0.150	Mouse
regulation of skeletal muscle fiber development	GO:0048742	36	0.150
cell substrate adhesion	GO:0031589	130	0.149
cytokine production	GO:0001816	319	0.149
response to peptide	GO:1901652	136	0.148	Mouse
neuroblast proliferation	GO:0007405	49	0.148
stem cell maintenance	GO:0019827	130	0.146	Fly
lung induction	GO:0060492	3	0.146
digestive system development	GO:0055123	200	0.146
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.144
nucleobase containing small molecule metabolic process	GO:0055086	352	0.142
female gamete generation	GO:0007292	74	0.142
renal vesicle induction	GO:0072034	3	0.141
gtp catabolic process	GO:0006184	143	0.141
pallium development	GO:0021543	120	0.141
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.137
endodermal cell fate specification	GO:0001714	4	0.136
planar cell polarity pathway involved in cardiac right atrium morphogenesis	GO:0061349	2	0.135
transmembrane transport	GO:0055085	412	0.134
brain morphogenesis	GO:0048854	32	0.134
negative regulation of synapse assembly	GO:0051964	3	0.134
kidney epithelium development	GO:0072073	121	0.133	Mouse
positive regulation of dendrite development	GO:1900006	21	0.131
nucleotide catabolic process	GO:0009166	217	0.131
nucleoside metabolic process	GO:0009116	246	0.130
oocyte axis specification	GO:0007309	2	0.130
cellular response to lipid	GO:0071396	145	0.129
regulation of mitotic cell cycle	GO:0007346	126	0.128
locomotory behavior	GO:0007626	195	0.128
cellular homeostasis	GO:0019725	240	0.127
mitochondrion organization	GO:0007005	134	0.127
regulation of metal ion transport	GO:0010959	106	0.126
myeloid cell differentiation	GO:0030099	233	0.126	Mouse
heterocycle catabolic process	GO:0046700	280	0.126
negative regulation of immune system process	GO:0002683	209	0.123	Mouse
cerebral cortex development	GO:0021987	86	0.123
mesoderm development	GO:0007498	100	0.123	Mouse
dephosphorylation	GO:0016311	129	0.122
defense response to other organism	GO:0098542	197	0.122
rho protein signal transduction	GO:0007266	32	0.121
positive regulation of mitotic cell cycle phase transition	GO:1901992	17	0.121
stem cell proliferation	GO:0072089	117	0.121
negative regulation of calcium ion dependent exocytosis	GO:0045955	3	0.121
positive regulation of mapk cascade	GO:0043410	170	0.120
ion transmembrane transport	GO:0034220	361	0.120
purine nucleoside metabolic process	GO:0042278	241	0.120
negative regulation of cell fate specification	GO:0009996	4	0.120
ciliary body morphogenesis	GO:0061073	3	0.119	Mouse
negative regulation of cell morphogenesis involved in differentiation	GO:0010771	48	0.119
nucleoside phosphate metabolic process	GO:0006753	338	0.119
regulation of fat cell differentiation	GO:0045598	81	0.118	Mouse
purine containing compound metabolic process	GO:0072521	311	0.118
response to starvation	GO:0042594	65	0.117
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.115
notch signaling pathway	GO:0007219	71	0.115	Mouse Fly
purine containing compound catabolic process	GO:0072523	213	0.114
regulation of cellular component size	GO:0032535	121	0.114
sensory organ boundary specification	GO:0008052	1	0.112
canonical wnt signaling pathway	GO:0060070	130	0.112
cell maturation	GO:0048469	127	0.112
negative regulation of cell migration	GO:0030336	59	0.112	Mouse
lung field specification	GO:0060424	3	0.111
positive regulation of mesoderm development	GO:2000382	2	0.110
cilium assembly	GO:0042384	81	0.110
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.109
ear morphogenesis	GO:0042471	118	0.109
positive regulation of notch signaling pathway	GO:0045747	18	0.108	Mouse
cell growth	GO:0016049	130	0.108
negative regulation of cell motility	GO:2000146	61	0.108	Mouse
positive regulation of growth	GO:0045927	104	0.107
regulation of cardioblast differentiation	GO:0051890	3	0.107
neurotransmitter transport	GO:0006836	76	0.107
cerebral cortex cell migration	GO:0021795	44	0.107
protein modification by small protein conjugation or removal	GO:0070647	207	0.107
cardiac muscle cell differentiation	GO:0055007	69	0.106
planar cell polarity pathway involved in heart morphogenesis	GO:0061346	3	0.105
planar cell polarity pathway involved in outflow tract morphogenesis	GO:0061347	2	0.105
cell fate commitment	GO:0045165	210	0.105
muscle cell development	GO:0055001	133	0.104
anatomical structure maturation	GO:0071695	49	0.104
vascular smooth muscle cell differentiation	GO:0035886	11	0.103
regulation of membrane potential	GO:0042391	192	0.103
cellular response to molecule of bacterial origin	GO:0071219	83	0.103
positive regulation of protein catabolic process	GO:0045732	60	0.102
wound healing	GO:0042060	157	0.101
carbohydrate metabolic process	GO:0005975	230	0.100
positive regulation of secretion by cell	GO:1903532	114	0.100
purine nucleotide metabolic process	GO:0006163	302	0.100
segment specification	GO:0007379	15	0.100	Mouse
hormone secretion	GO:0046879	128	0.100
muscle cell differentiation	GO:0042692	261	0.100
negative regulation of epithelial cell migration	GO:0010633	9	0.100	Mouse
negative regulation of cell growth	GO:0030308	44	0.099
positive regulation of cell death	GO:0010942	224	0.099
endochondral bone morphogenesis	GO:0060350	50	0.098
inner ear morphogenesis	GO:0042472	101	0.097
spinal cord motor neuron differentiation	GO:0021522	35	0.097	Zebrafish
embryonic epithelial tube formation	GO:0001838	130	0.097
labyrinthine layer blood vessel development	GO:0060716	21	0.096
regulation of nuclear division	GO:0051783	56	0.096
gastrulation	GO:0007369	116	0.096
positive regulation of organelle organization	GO:0010638	128	0.096
multi multicellular organism process	GO:0044706	109	0.095
erk1 and erk2 cascade	GO:0070371	77	0.095
regulation of vesicle mediated transport	GO:0060627	139	0.095
cardiac cell fate specification	GO:0060912	2	0.094
negative regulation of lipid metabolic process	GO:0045833	30	0.093
primary neural tube formation	GO:0014020	95	0.093
positive regulation of ossification	GO:0045778	47	0.092	Mouse
regulation of muscle tissue development	GO:1901861	97	0.092
regulation of branching involved in salivary gland morphogenesis	GO:0060693	11	0.092
regulation of reproductive process	GO:2000241	66	0.091
fat cell differentiation	GO:0045444	160	0.091	Mouse
axis elongation involved in somitogenesis	GO:0090245	4	0.091
regulation of osteoblast differentiation	GO:0045667	67	0.091	Mouse
modification dependent macromolecule catabolic process	GO:0043632	133	0.091
ascending aorta morphogenesis	GO:0035910	3	0.090
midbrain hindbrain boundary development	GO:0030917	9	0.090
neural tube closure	GO:0001843	90	0.090
intracellular protein transport	GO:0006886	204	0.090
positive regulation of transcription from rna polymerase ii promoter in response to stress	GO:0036003	3	0.089
neural tube patterning	GO:0021532	43	0.089
salivary gland morphogenesis	GO:0007435	33	0.089	Fly
inorganic cation transmembrane transport	GO:0098662	207	0.089
neuromuscular process	GO:0050905	99	0.088
cellular carbohydrate metabolic process	GO:0044262	119	0.088
regulation of cellular amino acid metabolic process	GO:0006521	5	0.087
diencephalon development	GO:0021536	63	0.087
neuronal stem cell division	GO:0036445	10	0.087
innate immune response	GO:0045087	157	0.087
blood circulation	GO:0008015	195	0.087
tube closure	GO:0060606	91	0.087
embryonic heart tube development	GO:0035050	65	0.087	Mouse
cellular nitrogen compound catabolic process	GO:0044270	280	0.086
filopodium assembly	GO:0046847	19	0.086
positive regulation of protein phosphorylation	GO:0001934	242	0.086
hematopoietic progenitor cell differentiation	GO:0002244	143	0.086
myoblast differentiation	GO:0045445	52	0.086
thyroid stimulating hormone secreting cell differentiation	GO:0060129	4	0.086
cellular response to oxidative stress	GO:0034599	76	0.086
defense response to bacterium	GO:0042742	119	0.086
outflow tract morphogenesis	GO:0003151	53	0.086	Mouse
chemotaxis	GO:0006935	247	0.085
nucleoside triphosphate catabolic process	GO:0009143	205	0.085
regulation of wnt signaling pathway	GO:0030111	123	0.085
negative regulation of mechanoreceptor differentiation	GO:0045632	3	0.085	Mouse
small molecule biosynthetic process	GO:0044283	132	0.084
mitral valve development	GO:0003174	4	0.084
cell chemotaxis	GO:0060326	81	0.083
protein maturation	GO:0051604	176	0.082
regulation of exocytosis	GO:0017157	61	0.082
positive regulation of stem cell proliferation	GO:2000648	59	0.082
calcium ion transport	GO:0006816	159	0.082
cytokine mediated signaling pathway	GO:0019221	115	0.081
protein import into nucleus	GO:0006606	95	0.081
placenta blood vessel development	GO:0060674	31	0.081
tissue migration	GO:0090130	68	0.080	Mouse
nucleotide metabolic process	GO:0009117	332	0.080
mesangial cell differentiation	GO:0072007	4	0.080
endothelial cell migration	GO:0043542	44	0.080	Mouse
pericardium development	GO:0060039	16	0.080	Mouse
canonical wnt signaling pathway involved in regulation of cell proliferation	GO:0044340	3	0.079
aromatic compound catabolic process	GO:0019439	286	0.079
regulation of binding	GO:0051098	111	0.079
establishment of protein localization to membrane	GO:0090150	54	0.079
prostate gland morphogenesis	GO:0060512	32	0.078
apoptotic signaling pathway	GO:0097190	306	0.078
trabecula morphogenesis	GO:0061383	40	0.078	Mouse
regulation of apoptotic signaling pathway	GO:2001233	197	0.078
positive regulation of epithelial cell proliferation	GO:0050679	68	0.078
nucleoside triphosphate metabolic process	GO:0009141	230	0.077
regulation of leukocyte differentiation	GO:1902105	159	0.077
positive regulation of organ growth	GO:0046622	29	0.077
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	1	0.077
venous blood vessel morphogenesis	GO:0048845	7	0.077
regulation of cellular response to stress	GO:0080135	159	0.077
positive regulation of protein modification process	GO:0031401	299	0.076
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.076
peptidyl amino acid modification	GO:0018193	336	0.076
keratinocyte differentiation	GO:0030216	48	0.076
cellular metal ion homeostasis	GO:0006875	151	0.075
positive regulation of nervous system development	GO:0051962	221	0.075
actin filament bundle assembly	GO:0051017	40	0.075
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.075
muscle cell proliferation	GO:0033002	52	0.075
g protein coupled receptor signaling pathway	GO:0007186	243	0.075
cytoplasmic transport	GO:0016482	234	0.074
regulation of lymphocyte activation	GO:0051249	240	0.074
neuroepithelial cell differentiation	GO:0060563	37	0.073
positive regulation of cell division	GO:0051781	31	0.073
oxygen homeostasis	GO:0032364	2	0.073
leukocyte apoptotic process	GO:0071887	71	0.073
hair cycle phase	GO:0044851	16	0.072
regulation of transporter activity	GO:0032409	57	0.072
positive regulation of cell cycle process	GO:0090068	61	0.072
response to organic cyclic compound	GO:0014070	198	0.072
regulation of protein kinase activity	GO:0045859	232	0.071
lung development	GO:0030324	164	0.071
establishment of synaptic vesicle localization	GO:0097480	57	0.071
positive regulation of nuclear division	GO:0051785	27	0.071
epithelial cell fate commitment	GO:0072148	13	0.070
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.070
tube formation	GO:0035148	140	0.070
purine nucleoside catabolic process	GO:0006152	205	0.069
neuroblast differentiation	GO:0014016	2	0.069
positive regulation of osteoblast differentiation	GO:0045669	34	0.069	Mouse
establishment of organ orientation	GO:0048561	1	0.069
carbohydrate homeostasis	GO:0033500	128	0.068
rhombomere morphogenesis	GO:0021593	2	0.068
embryonic skeletal system morphogenesis	GO:0048704	91	0.068
receptor mediated endocytosis	GO:0006898	51	0.068
response to lipopolysaccharide	GO:0032496	128	0.068
photoreceptor cell differentiation	GO:0046530	52	0.068
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.067
regulation of cell division	GO:0051302	76	0.067
urogenital system development	GO:0001655	261	0.066	Zebrafish Mouse
forebrain cell migration	GO:0021885	58	0.066
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.066
nephron epithelium development	GO:0072009	92	0.066	Mouse
regulation of calcium ion dependent exocytosis	GO:0017158	16	0.066
positive regulation of map kinase activity	GO:0043406	84	0.065
positive regulation of epithelial cell proliferation involved in lung morphogenesis	GO:0060501	3	0.065
mesonephric epithelium development	GO:0072163	94	0.065
ureteric bud development	GO:0001657	94	0.065
positive regulation of mesenchymal cell proliferation	GO:0002053	33	0.065
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.065
branch elongation involved in salivary gland morphogenesis	GO:0060667	2	0.064
regulation of ion transport	GO:0043269	215	0.064
growth involved in heart morphogenesis	GO:0003241	4	0.064
regulation of blood circulation	GO:1903522	93	0.064
actin filament organization	GO:0007015	113	0.063
purine ribonucleotide metabolic process	GO:0009150	290	0.063
neural crest cell migration involved in autonomic nervous system development	GO:1901166	5	0.063
stress activated mapk cascade	GO:0051403	80	0.063
developmental programmed cell death	GO:0010623	41	0.063
hair follicle development	GO:0001942	85	0.063
mitotic nuclear division	GO:0007067	48	0.063
protein autophosphorylation	GO:0046777	61	0.063
response to light stimulus	GO:0009416	135	0.063
central nervous system vasculogenesis	GO:0022009	3	0.062
peripheral nervous system neuron axonogenesis	GO:0048936	3	0.062
regulation of insulin receptor signaling pathway	GO:0046626	21	0.062
sprouting angiogenesis	GO:0002040	26	0.062
neuron apoptotic process	GO:0051402	142	0.062
negative regulation of triglyceride biosynthetic process	GO:0010868	2	0.062
multicellular organismal reproductive behavior	GO:0033057	23	0.062
regulation of cell cycle phase transition	GO:1901987	77	0.062
purine ribonucleotide catabolic process	GO:0009154	208	0.062
regulation of hormone levels	GO:0010817	211	0.062
plasma membrane organization	GO:0007009	90	0.061
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.061
organonitrogen compound biosynthetic process	GO:1901566	192	0.061
establishment of endothelial blood brain barrier	GO:0014045	3	0.061
negative regulation of ossification	GO:0030279	49	0.061
neuroblast division	GO:0055057	10	0.061
response to growth factor	GO:0070848	198	0.061
myotube differentiation	GO:0014902	105	0.061
sensory perception of mechanical stimulus	GO:0050954	107	0.061
establishment of planar polarity involved in nephron morphogenesis	GO:0072046	1	0.061
lipid biosynthetic process	GO:0008610	179	0.061
branching involved in salivary gland morphogenesis	GO:0060445	26	0.061
extracellular structure organization	GO:0043062	148	0.060
central nervous system morphogenesis	GO:0021551	2	0.060
ventricular cardiac muscle cell action potential	GO:0086005	4	0.060
t cell activation	GO:0042110	289	0.060
regulation of filopodium assembly	GO:0051489	13	0.060
regulation of defense response	GO:0031347	233	0.060
regulation of stem cell proliferation	GO:0072091	78	0.060
morphogenesis of an epithelial fold	GO:0060571	28	0.060
positive regulation of cardiac muscle tissue development	GO:0055025	19	0.060
cellular response to biotic stimulus	GO:0071216	92	0.060
blastoderm segmentation	GO:0007350	13	0.060
regulation of neurotransmitter levels	GO:0001505	87	0.059
fibroblast growth factor receptor signaling pathway	GO:0008543	46	0.059
modification dependent protein catabolic process	GO:0019941	133	0.059
regulation of protein transport	GO:0051223	163	0.059
circulatory system process	GO:0003013	197	0.059
type b pancreatic cell proliferation	GO:0044342	10	0.058
heart contraction	GO:0060047	93	0.058
habenula development	GO:0021986	2	0.058
regulation of proteolysis	GO:0030162	164	0.058
establishment of planar polarity involved in neural tube closure	GO:0090177	15	0.058
single organismal cell cell adhesion	GO:0016337	131	0.057
regulation of protein localization	GO:0032880	231	0.057
regulation of leukocyte proliferation	GO:0070663	121	0.057
regulation of endothelial cell chemotaxis	GO:2001026	1	0.057
respiratory tube development	GO:0030323	167	0.057
response to organonitrogen compound	GO:0010243	246	0.057	Mouse
organic hydroxy compound biosynthetic process	GO:1901617	77	0.057
sulfur compound metabolic process	GO:0006790	100	0.057
glycerolipid metabolic process	GO:0046486	122	0.056
nephron tubule development	GO:0072080	84	0.056	Mouse

Jag2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.198
cardiovascular system disease	DOID:1287	0.198
heart disease	DOID:114	0.164
musculoskeletal system disease	DOID:17	0.126
nervous system disease	DOID:863	0.110

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