IMP: Integrative Multi-species Prediction

Mus musculus

118 known processes

Pdgfa

platelet derived growth factor, alpha

Ensembl: ENSMUSG00000025856
Entrez: 18590
UniProtKB: Q99L56
UniProtKB: G5E891
UniProtKB: P20033

Process Predictions
Disease Predictions

Pdgfa biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
response to growth factor	GO:0070848	198	0.443	Mouse
peptidyl amino acid modification	GO:0018193	336	0.436
cellular amine metabolic process	GO:0044106	44	0.396
negative regulation of cell proliferation	GO:0008285	296	0.298	Mouse
epithelial tube morphogenesis	GO:0060562	303	0.275	Mouse Fly
cellular amino acid metabolic process	GO:0006520	103	0.275
regulation of cell motility	GO:2000145	236	0.264	Human Mouse
activation of transmembrane receptor protein tyrosine kinase activity	GO:0007171	3	0.252
positive regulation of protein kinase activity	GO:0045860	144	0.249	Human
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.247
positive regulation of cell migration	GO:0030335	109	0.247	Human Mouse
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.233	Human Mouse
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.228	Mouse
response to radiation	GO:0009314	165	0.226	Fly
cellular response to amino acid stimulus	GO:0071230	29	0.225
blood vessel morphogenesis	GO:0048514	285	0.218
skeletal system development	GO:0001501	356	0.216
embryonic organ morphogenesis	GO:0048562	276	0.213
regulation of bmp signaling pathway	GO:0030510	60	0.213
striated muscle tissue development	GO:0014706	293	0.211	Mouse
cellular response to growth factor stimulus	GO:0071363	197	0.211	Mouse
regulation of apoptotic signaling pathway	GO:2001233	197	0.211	Mouse
negative regulation of protein metabolic process	GO:0051248	282	0.211
muscle tissue development	GO:0060537	308	0.207	Mouse
regulation of cell migration	GO:0030334	219	0.205	Human Mouse
peptidyl tyrosine phosphorylation	GO:0018108	143	0.204
gland development	GO:0048732	330	0.201
regulation of cellular amine metabolic process	GO:0033238	20	0.200
regulation of cellular ketone metabolic process	GO:0010565	66	0.199
response to transforming growth factor beta	GO:0071559	88	0.196
angiogenesis	GO:0001525	201	0.192
cellular ketone metabolic process	GO:0042180	84	0.187
branching morphogenesis of an epithelial tube	GO:0048754	159	0.181	Mouse
digestive tract morphogenesis	GO:0048546	147	0.176	Fly
g protein coupled receptor signaling pathway	GO:0007186	243	0.173
cell growth	GO:0016049	130	0.172	Mouse
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	26	0.172
amine metabolic process	GO:0009308	45	0.166
negative regulation of cellular response to growth factor stimulus	GO:0090288	46	0.165
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.165
negative regulation of intracellular signal transduction	GO:1902532	167	0.156
kidney development	GO:0001822	213	0.156	Human Mouse
epithelial cell proliferation	GO:0050673	174	0.155	Mouse
ossification	GO:0001503	216	0.151
epithelial cell development	GO:0002064	159	0.151	Mouse Fly
forebrain development	GO:0030900	302	0.151
regionalization	GO:0003002	337	0.149
connective tissue development	GO:0061448	179	0.148	Mouse
negative regulation of fat cell differentiation	GO:0045599	36	0.146
neuron projection guidance	GO:0097485	141	0.146	Mouse
stem cell differentiation	GO:0048863	268	0.144
regulation of organ morphogenesis	GO:2000027	144	0.143
ameboidal type cell migration	GO:0001667	128	0.141	Mouse Fly
morphogenesis of a branching structure	GO:0001763	203	0.139
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.137
regulation of kinase activity	GO:0043549	249	0.137	Human
regulation of proteolysis	GO:0030162	164	0.136
regulation of system process	GO:0044057	200	0.135	Mouse
sensory organ morphogenesis	GO:0090596	242	0.134	Mouse
positive regulation of cell development	GO:0010720	237	0.132	Mouse
regulation of transferase activity	GO:0051338	263	0.130	Human
cartilage development	GO:0051216	140	0.130
cardiac muscle tissue development	GO:0048738	130	0.129	Mouse
morphogenesis of a branching epithelium	GO:0061138	193	0.128
regulation of cell substrate adhesion	GO:0010810	73	0.128	Mouse
gastrulation	GO:0007369	116	0.127
glycoprotein biosynthetic process	GO:0009101	89	0.127	Mouse
apoptotic signaling pathway	GO:0097190	306	0.125	Mouse
cardiocyte differentiation	GO:0035051	87	0.124	Mouse
digestive tract development	GO:0048565	190	0.124
negative regulation of molecular function	GO:0044092	258	0.123
circulatory system process	GO:0003013	197	0.122	Mouse
positive regulation of cell motility	GO:2000147	116	0.122	Human Mouse
response to organonitrogen compound	GO:0010243	246	0.122
regulation of protein localization	GO:0032880	231	0.121
negative regulation of cellular protein metabolic process	GO:0032269	247	0.120
regulation of cell cycle	GO:0051726	281	0.116	Mouse
skeletal system morphogenesis	GO:0048705	203	0.115
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.115
mesoderm development	GO:0007498	100	0.114	Mouse
positive regulation of cell death	GO:0010942	224	0.114
developmental growth involved in morphogenesis	GO:0060560	138	0.113	Mouse
regulation of endopeptidase activity	GO:0052548	89	0.111
positive regulation of cell growth	GO:0030307	33	0.110	Mouse
negative regulation of protein modification process	GO:0031400	163	0.109
regulation of neuron differentiation	GO:0045664	281	0.109	Mouse
axonogenesis	GO:0007409	274	0.107	Mouse
negative regulation of protein phosphorylation	GO:0001933	126	0.105
regulation of protein kinase activity	GO:0045859	232	0.105	Human
regulation of binding	GO:0051098	111	0.105
single organism cell adhesion	GO:0098602	156	0.104	Mouse
bone morphogenesis	GO:0060349	78	0.104
sensory perception	GO:0007600	245	0.104
developmental cell growth	GO:0048588	84	0.103	Mouse
negative regulation of phosphorus metabolic process	GO:0010563	184	0.103	Human
regulation of hydrolase activity	GO:0051336	246	0.102
negative regulation of phosphate metabolic process	GO:0045936	184	0.100	Human
gonad development	GO:0008406	141	0.100	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	5	0.100
wnt signaling pathway	GO:0016055	188	0.098
cardiac muscle contraction	GO:0060048	32	0.098	Mouse
regulation of organelle organization	GO:0033043	289	0.097
positive regulation of protein phosphorylation	GO:0001934	242	0.097	Human Mouse
positive regulation of neuron differentiation	GO:0045666	141	0.096	Mouse
epidermis development	GO:0008544	187	0.096
response to amino acid	GO:0043200	37	0.096
stem cell development	GO:0048864	219	0.095
positive regulation of cell projection organization	GO:0031346	95	0.095	Mouse
regulation of peptidase activity	GO:0052547	96	0.094
fibroblast growth factor receptor signaling pathway	GO:0008543	46	0.092	Mouse
renal system process	GO:0003014	48	0.091	Mouse
bmp signaling pathway	GO:0030509	93	0.091
morphogenesis of embryonic epithelium	GO:0016331	159	0.091	Mouse
chemotaxis	GO:0006935	247	0.091	Human Mouse
respiratory system development	GO:0060541	190	0.088
cellular response to acid chemical	GO:0071229	68	0.088
action potential	GO:0001508	78	0.087
positive regulation of programmed cell death	GO:0043068	218	0.087
intrinsic apoptotic signaling pathway	GO:0097193	132	0.087
regulation of cellular component size	GO:0032535	121	0.086	Mouse
chondrocyte differentiation	GO:0002062	72	0.086
regulation of fibroblast proliferation	GO:0048145	34	0.086	Human
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.085
cell adhesion	GO:0007155	329	0.084	Mouse
regulation of protein serine threonine kinase activity	GO:0071900	157	0.084	Human
gtp catabolic process	GO:0006184	143	0.083
synapse organization	GO:0050808	125	0.081
formation of primary germ layer	GO:0001704	77	0.080
fibroblast proliferation	GO:0048144	35	0.080	Human
defense response to other organism	GO:0098542	197	0.080
positive regulation of kinase activity	GO:0033674	155	0.079	Human
macromolecule catabolic process	GO:0009057	281	0.079
regulation of cell cycle process	GO:0010564	160	0.079
negative regulation of nervous system development	GO:0051961	156	0.078
bone development	GO:0060348	120	0.077
digestive system development	GO:0055123	200	0.076
blood circulation	GO:0008015	195	0.075	Mouse
negative regulation of cell migration	GO:0030336	59	0.075	Mouse
cell fate commitment	GO:0045165	210	0.075
biomineral tissue development	GO:0031214	64	0.075
dna metabolic process	GO:0006259	303	0.074	Human
cell junction assembly	GO:0034329	52	0.074
muscle system process	GO:0003012	141	0.073	Mouse
cellular protein complex assembly	GO:0043623	116	0.072
ventricular cardiac muscle cell action potential	GO:0086005	4	0.071
salivary gland development	GO:0007431	37	0.070
central nervous system neuron differentiation	GO:0021953	162	0.070
developmental programmed cell death	GO:0010623	41	0.070
regulation of epithelial cell proliferation	GO:0050678	141	0.070	Mouse
negative regulation of bmp signaling pathway	GO:0030514	35	0.070
negative regulation of immune system process	GO:0002683	209	0.070
epithelial cell morphogenesis	GO:0003382	41	0.070
neuron migration	GO:0001764	122	0.069
neuron projection extension	GO:1990138	64	0.069	Mouse
regulation of membrane potential	GO:0042391	192	0.068
cell junction organization	GO:0034330	77	0.068
positive regulation of apoptotic process	GO:0043065	217	0.068
skeletal muscle organ development	GO:0060538	163	0.068
protein catabolic process	GO:0030163	221	0.067
stem cell maintenance	GO:0019827	130	0.067
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.067
negative regulation of neuron differentiation	GO:0045665	101	0.067
transmembrane transport	GO:0055085	412	0.066
regulation of cellular response to stress	GO:0080135	159	0.065
actin filament based movement	GO:0030048	23	0.065
tube formation	GO:0035148	140	0.064
muscle cell differentiation	GO:0042692	261	0.063	Mouse
organ growth	GO:0035265	117	0.063
camera type eye development	GO:0043010	266	0.063	Mouse
response to light stimulus	GO:0009416	135	0.062
bone mineralization	GO:0030282	54	0.061
regulation of actin filament based process	GO:0032970	99	0.061
regulation of striated muscle cell differentiation	GO:0051153	81	0.061
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	43	0.061
heart contraction	GO:0060047	93	0.061	Mouse
regulation of protein transport	GO:0051223	163	0.061
negative regulation of cellular component organization	GO:0051129	194	0.061
tissue migration	GO:0090130	68	0.061	Mouse Fly
epithelial cell migration	GO:0010631	63	0.059	Mouse Fly
vegf activated neuropilin signaling pathway	GO:0038190	2	0.059	Mouse
heart process	GO:0003015	94	0.058	Mouse
rho protein signal transduction	GO:0007266	32	0.058
single organismal cell cell adhesion	GO:0016337	131	0.058	Mouse
positive regulation of nervous system development	GO:0051962	221	0.057	Mouse
extrinsic apoptotic signaling pathway	GO:0097191	126	0.057	Mouse
heart morphogenesis	GO:0003007	178	0.057	Mouse
skin development	GO:0043588	220	0.057
muscle cell development	GO:0055001	133	0.056	Mouse
regulation of cell growth	GO:0001558	91	0.055	Mouse
odontogenesis of dentin containing tooth	GO:0042475	66	0.055
regulation of cartilage development	GO:0061035	44	0.055
ear development	GO:0043583	200	0.055
actin cytoskeleton organization	GO:0030036	220	0.055
central nervous system neuron development	GO:0021954	67	0.055
cytokine production	GO:0001816	319	0.055
regulation of blood circulation	GO:1903522	93	0.055
epithelium migration	GO:0090132	63	0.055	Mouse Fly
cation transport	GO:0006812	399	0.054
negative regulation of phosphorylation	GO:0042326	166	0.054
regulation of extent of cell growth	GO:0061387	52	0.054	Mouse
adherens junction assembly	GO:0034333	22	0.054
protein localization to plasma membrane	GO:0072659	57	0.054
multi multicellular organism process	GO:0044706	109	0.054
skeletal muscle fiber development	GO:0048741	58	0.053
positive regulation of neuron projection development	GO:0010976	79	0.053	Mouse
actin mediated cell contraction	GO:0070252	15	0.053
endochondral bone morphogenesis	GO:0060350	50	0.053
cellular response to gamma radiation	GO:0071480	4	0.053
odontogenesis	GO:0042476	78	0.053
regulation of cell adhesion	GO:0030155	154	0.052	Mouse
regulation of chromatin modification	GO:1903308	57	0.052
embryonic skeletal system development	GO:0048706	120	0.052
positive regulation of cytokine production	GO:0001819	174	0.052
positive regulation of cellular amine metabolic process	GO:0033240	5	0.052
regulation of intracellular transport	GO:0032386	159	0.052
cell matrix adhesion	GO:0007160	68	0.052	Mouse
telencephalon development	GO:0021537	186	0.051
muscle contraction	GO:0006936	101	0.050	Mouse
myeloid leukocyte activation	GO:0002274	83	0.050
regulation of cellular component biogenesis	GO:0044087	181	0.050
striated muscle contraction	GO:0006941	45	0.050	Mouse
membrane organization	GO:0061024	245	0.049
regulation of chondrocyte differentiation	GO:0032330	33	0.049
positive regulation of protein modification process	GO:0031401	299	0.048	Human Mouse
hemostasis	GO:0007599	78	0.048	Human
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.048	Mouse
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.047	Mouse
cell type specific apoptotic process	GO:0097285	268	0.046	Mouse
lymphocyte proliferation	GO:0046651	164	0.046
calcium ion transport	GO:0006816	159	0.046
extracellular structure organization	GO:0043062	148	0.046
developmental maturation	GO:0021700	193	0.046	Mouse
establishment of endothelial blood brain barrier	GO:0014045	3	0.046
stem cell proliferation	GO:0072089	117	0.046
regulation of chemotaxis	GO:0050920	53	0.045	Mouse
regulation of dna replication	GO:0006275	17	0.045	Human
response to oxygen levels	GO:0070482	62	0.045
regulation of canonical wnt signaling pathway	GO:0060828	82	0.045
cell cell junction organization	GO:0045216	72	0.045
regulation of ion transport	GO:0043269	215	0.045
appendage development	GO:0048736	166	0.044
regulation of osteoblast differentiation	GO:0045667	67	0.044
transmission of nerve impulse	GO:0019226	76	0.044
positive regulation of smooth muscle cell migration	GO:0014911	4	0.044	Mouse
cell maturation	GO:0048469	127	0.044	Mouse
regulation of embryonic development	GO:0045995	71	0.044	Mouse
erythrocyte differentiation	GO:0030218	88	0.044	Mouse
regulation of anatomical structure size	GO:0090066	178	0.043	Mouse
myotube differentiation	GO:0014902	105	0.043
retinal ganglion cell axon guidance	GO:0031290	18	0.043	Mouse
response to organic cyclic compound	GO:0014070	198	0.043
positive regulation of cell adhesion	GO:0045785	80	0.043	Mouse
regulation of myotube differentiation	GO:0010830	62	0.043
positive regulation of protein transport	GO:0051222	93	0.043
fat cell differentiation	GO:0045444	160	0.043
urogenital system development	GO:0001655	261	0.043	Human Mouse Fly
germ cell development	GO:0007281	185	0.042	Fly
protein localization to membrane	GO:0072657	108	0.042
regulation of secretion	GO:0051046	274	0.042
anatomical structure homeostasis	GO:0060249	145	0.042	Mouse
metanephros development	GO:0001656	79	0.042	Human Mouse
mitral valve development	GO:0003174	4	0.042
segmentation	GO:0035282	93	0.041
hematopoietic progenitor cell differentiation	GO:0002244	143	0.041	Mouse
regulation of blood pressure	GO:0008217	93	0.041	Mouse
respiratory tube development	GO:0030323	167	0.041
neural tube closure	GO:0001843	90	0.041
multicellular organismal homeostasis	GO:0048871	164	0.041	Mouse
divalent metal ion transport	GO:0070838	172	0.040
photoreceptor cell differentiation	GO:0046530	52	0.040	Mouse
ras protein signal transduction	GO:0007265	77	0.040
regulation of exocytosis	GO:0017157	61	0.040
regulation of wnt signaling pathway	GO:0030111	123	0.040
neuronal action potential	GO:0019228	54	0.040
regulation of protein secretion	GO:0050708	82	0.040
tissue homeostasis	GO:0001894	115	0.040	Mouse
regulation of ossification	GO:0030278	112	0.040
regulation of t cell activation	GO:0050863	170	0.039
negative regulation of cell development	GO:0010721	169	0.039
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.039	Mouse
axon guidance	GO:0007411	141	0.039	Mouse
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.039
regulation of defense response	GO:0031347	233	0.038
regulation of cell projection organization	GO:0031344	206	0.038	Mouse
covalent chromatin modification	GO:0016569	163	0.038
multicellular organismal signaling	GO:0035637	91	0.038
immune effector process	GO:0002252	321	0.038
actin filament organization	GO:0007015	113	0.038
regulation of cytokine production	GO:0001817	266	0.038
nucleotide catabolic process	GO:0009166	217	0.038
mitral valve morphogenesis	GO:0003183	4	0.038
pallium development	GO:0021543	120	0.038
t cell activation	GO:0042110	289	0.038
endothelial cell migration	GO:0043542	44	0.038	Mouse
cellular macromolecule catabolic process	GO:0044265	206	0.038
cation transmembrane transport	GO:0098655	266	0.038
protein maturation	GO:0051604	176	0.038
lens development in camera type eye	GO:0002088	62	0.038
regulation of endocytosis	GO:0030100	69	0.037
negative regulation of cell cycle	GO:0045786	123	0.037
regulation of neuron projection development	GO:0010975	169	0.037	Mouse
microtubule based process	GO:0007017	236	0.037
negative regulation of cell adhesion	GO:0007162	45	0.037	Mouse
somitogenesis	GO:0001756	69	0.037
positive regulation of fibroblast proliferation	GO:0048146	20	0.036	Human
regulation of cellular catabolic process	GO:0031329	242	0.036
syncytium formation	GO:0006949	43	0.036
sequestering of calcium ion	GO:0051208	18	0.036
localization within membrane	GO:0051668	4	0.036
autonomic nervous system development	GO:0048483	43	0.036
determination of left right symmetry	GO:0007368	80	0.036
positive regulation of proteolysis	GO:0045862	85	0.036
vascular endothelial growth factor signaling pathway	GO:0038084	10	0.035	Mouse
compound eye development	GO:0048749	1	0.035
nephron epithelium morphogenesis	GO:0072088	68	0.035	Mouse
negative regulation of cell motility	GO:2000146	61	0.035	Mouse
modification dependent macromolecule catabolic process	GO:0043632	133	0.035
positive regulation of peptidase activity	GO:0010952	49	0.035
hindbrain development	GO:0030902	128	0.034
locomotory behavior	GO:0007626	195	0.034
regulation of establishment of protein localization	GO:0070201	181	0.034
cellular response to abiotic stimulus	GO:0071214	56	0.034	Fly
neural precursor cell proliferation	GO:0061351	121	0.034	Mouse
regulation of secretion by cell	GO:1903530	249	0.034
regulation of homeostatic process	GO:0032844	182	0.034
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.034
detection of external stimulus	GO:0009581	61	0.034
regulation of muscle tissue development	GO:1901861	97	0.034
epithelial tube formation	GO:0072175	130	0.033
somite development	GO:0061053	81	0.033
appendage morphogenesis	GO:0035107	149	0.033
embryonic limb morphogenesis	GO:0030326	126	0.033
positive regulation of hydrolase activity	GO:0051345	148	0.033
regulation of heart contraction	GO:0008016	77	0.033
negative regulation of ossification	GO:0030279	49	0.033
regulation of mapk cascade	GO:0043408	248	0.032	Human Mouse
development of primary sexual characteristics	GO:0045137	143	0.032	Mouse
myeloid cell differentiation	GO:0030099	233	0.032	Mouse
positive regulation of growth	GO:0045927	104	0.032	Mouse
blood vessel endothelial cell migration	GO:0043534	23	0.032
mapk cascade	GO:0000165	281	0.032	Human Mouse
retina development in camera type eye	GO:0060041	119	0.032
placenta development	GO:0001890	140	0.032	Mouse
mesenchymal cell proliferation	GO:0010463	44	0.032
development of primary female sexual characteristics	GO:0046545	73	0.032	Mouse
i kappab kinase nf kappab signaling	GO:0007249	85	0.031
positive regulation of lymphocyte activation	GO:0051251	140	0.031
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.031
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.031
leukocyte differentiation	GO:0002521	342	0.031
negative regulation of wnt signaling pathway	GO:0030178	73	0.031
cellular component assembly involved in morphogenesis	GO:0010927	139	0.031
regulation of axon extension	GO:0030516	43	0.031	Mouse
regulation of cytokine biosynthetic process	GO:0042035	59	0.031
mesonephros development	GO:0001823	97	0.031	Mouse
endomembrane system organization	GO:0010256	147	0.030
nitrogen compound transport	GO:0071705	271	0.030
cellular response to extracellular stimulus	GO:0031668	81	0.030
mesonephric epithelium development	GO:0072163	94	0.030	Mouse
positive regulation of epithelial cell proliferation	GO:0050679	68	0.030	Mouse
ureteric bud development	GO:0001657	94	0.030	Mouse
neural tube formation	GO:0001841	108	0.030
regulation of response to wounding	GO:1903034	189	0.029	Human
mesoderm formation	GO:0001707	62	0.029
platelet derived growth factor receptor signaling pathway	GO:0048008	32	0.029	Human
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.029
positive regulation of osteoblast differentiation	GO:0045669	34	0.029
response to decreased oxygen levels	GO:0036293	59	0.029
adult behavior	GO:0030534	135	0.029
regulation of vesicle mediated transport	GO:0060627	139	0.029
activation of adenylate cyclase activity	GO:0007190	4	0.029
regulation of morphogenesis of a branching structure	GO:0060688	53	0.029
regulation of transmembrane transport	GO:0034762	128	0.029
regulation of fat cell differentiation	GO:0045598	81	0.029
negative regulation of epithelial cell proliferation	GO:0050680	64	0.029
carbohydrate metabolic process	GO:0005975	230	0.028	Mouse
cellular metal ion homeostasis	GO:0006875	151	0.028
renal system development	GO:0072001	225	0.028	Human Mouse Fly
muscle fiber development	GO:0048747	76	0.028	Mouse
intracellular protein transport	GO:0006886	204	0.028
visual perception	GO:0007601	52	0.028
mesenchymal cell development	GO:0014031	93	0.028
cellular response to fibroblast growth factor stimulus	GO:0044344	47	0.028	Mouse
modification dependent protein catabolic process	GO:0019941	133	0.028
protein localization to nucleus	GO:0034504	121	0.027
cytokine biosynthetic process	GO:0042089	68	0.027
limb development	GO:0060173	166	0.027
exocrine system development	GO:0035272	45	0.027
wound healing	GO:0042060	157	0.027	Human
regulation of mitotic cell cycle	GO:0007346	126	0.027	Mouse
detection of stimulus	GO:0051606	84	0.027
regulation of body fluid levels	GO:0050878	162	0.027	Human Mouse
regulation of intracellular protein transport	GO:0033157	82	0.027
muscle tissue morphogenesis	GO:0060415	53	0.027
peptidyl tyrosine modification	GO:0018212	145	0.027
peptidyl serine phosphorylation	GO:0018105	74	0.027
inorganic ion transmembrane transport	GO:0098660	234	0.027
organonitrogen compound biosynthetic process	GO:1901566	192	0.026
cellular chemical homeostasis	GO:0055082	215	0.026
protein modification by small protein conjugation	GO:0032446	187	0.026
negative regulation of protein processing	GO:0010955	79	0.026
positive regulation of axon extension	GO:0045773	20	0.026	Mouse
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.026
response to hypoxia	GO:0001666	58	0.026
cytokine metabolic process	GO:0042107	71	0.026
mesoderm morphogenesis	GO:0048332	64	0.026
regulation of neuron migration	GO:2001222	22	0.026
reactive oxygen species metabolic process	GO:0072593	84	0.026
metanephric nephron development	GO:0072210	34	0.026	Mouse
detection of abiotic stimulus	GO:0009582	60	0.025
leukocyte migration	GO:0050900	124	0.025
inflammatory response	GO:0006954	244	0.025
negative regulation of proteolysis	GO:0045861	74	0.025
protein modification by small protein conjugation or removal	GO:0070647	207	0.025
protein ubiquitination	GO:0016567	171	0.025
striated muscle myosin thick filament assembly	GO:0071688	1	0.025
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.025
focal adhesion assembly	GO:0048041	19	0.025
satellite cell activation involved in skeletal muscle regeneration	GO:0014901	3	0.025
response to inorganic substance	GO:0010035	96	0.025
myotube cell development	GO:0014904	60	0.025
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.025	Mouse
actin polymerization or depolymerization	GO:0008154	54	0.025
regulation of chromatin organization	GO:1902275	57	0.025
heart valve development	GO:0003170	23	0.024
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.024
skeletal muscle cell differentiation	GO:0035914	66	0.024
mitotic cell cycle process	GO:1903047	159	0.024
cell substrate adhesion	GO:0031589	130	0.024	Mouse
interleukin 8 production	GO:0032637	4	0.024
regulation of systemic arterial blood pressure	GO:0003073	61	0.024	Mouse
nucleoside triphosphate catabolic process	GO:0009143	205	0.024
protein kinase b signaling	GO:0043491	74	0.024	Human Mouse
nuclear transport	GO:0051169	139	0.024
negative regulation of homeostatic process	GO:0032845	71	0.024
cellular ion homeostasis	GO:0006873	165	0.024
organonitrogen compound catabolic process	GO:1901565	264	0.024
regulation of protein maturation	GO:1903317	96	0.024
canonical wnt signaling pathway	GO:0060070	130	0.024
telencephalon cell migration	GO:0022029	55	0.024
ensheathment of neurons	GO:0007272	76	0.024
regulation of cardiac cell fate specification	GO:2000043	1	0.024
cardiac muscle cell development	GO:0055013	39	0.024	Mouse
negative regulation of protein maturation	GO:1903318	79	0.023
organic hydroxy compound metabolic process	GO:1901615	203	0.023
positive regulation of retinal ganglion cell axon guidance	GO:1902336	2	0.023	Mouse
adherens junction organization	GO:0034332	28	0.023
cardiac muscle cell differentiation	GO:0055007	69	0.023	Mouse
negative regulation of cellular amine metabolic process	GO:0033239	1	0.023
ribose phosphate metabolic process	GO:0019693	291	0.023
cellular homeostasis	GO:0019725	240	0.023
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.023
feeding behavior	GO:0007631	62	0.023
male gamete generation	GO:0048232	285	0.023
regulation of angiogenesis	GO:0045765	81	0.023	Mouse
limb morphogenesis	GO:0035108	149	0.023
cellular response to external stimulus	GO:0071496	88	0.023
transforming growth factor beta2 production	GO:0032906	2	0.023
regulation of cell activation	GO:0050865	289	0.023	Human
cardiac chamber development	GO:0003205	108	0.023
regulation of multi organism process	GO:0043900	111	0.023
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.023	Fly
mitotic cytokinesis	GO:0000281	4	0.023
glycosyl compound metabolic process	GO:1901657	246	0.022
positive regulation of cytokine biosynthetic process	GO:0042108	40	0.022
molting cycle	GO:0042303	90	0.022
cardiac chamber morphogenesis	GO:0003206	93	0.022
formation of organ boundary	GO:0010160	1	0.022
cerebral cortex development	GO:0021987	86	0.022
regulation of skeletal muscle fiber development	GO:0048742	36	0.022
female sex differentiation	GO:0046660	84	0.022	Mouse
cellular calcium ion homeostasis	GO:0006874	119	0.022
divalent inorganic cation homeostasis	GO:0072507	138	0.022
positive regulation of mapk cascade	GO:0043410	170	0.022	Human Mouse
negative regulation of hydrolase activity	GO:0051346	71	0.022
rhodopsin mediated signaling pathway	GO:0016056	4	0.022
cell fate specification	GO:0001708	72	0.022
myosin filament assembly	GO:0031034	2	0.022
cell recognition	GO:0008037	83	0.022
cation homeostasis	GO:0055080	212	0.022
oxidation reduction process	GO:0055114	342	0.022
gtp metabolic process	GO:0046039	144	0.021
mesodermal cell migration	GO:0008078	4	0.021
layer formation in cerebral cortex	GO:0021819	13	0.021
salivary gland morphogenesis	GO:0007435	33	0.021
branching involved in salivary gland morphogenesis	GO:0060445	26	0.021

Pdgfa disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.073
musculoskeletal system disease	DOID:17	0.073
muscular disease	DOID:0080000	0.050
cancer	DOID:162	0.032
disease of cellular proliferation	DOID:14566	0.032
organ system cancer	DOID:0050686	0.025
nervous system disease	DOID:863	0.023
neuromuscular disease	DOID:440	0.021
neuropathy	DOID:870	0.021

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