IMP: Integrative Multi-species Prediction

Mus musculus

144 known processes

Nfe2l2

nuclear factor, erythroid derived 2, like 2

(Aliases: AI194320,Nrf2)

Ensembl: ENSMUSG00000015839
Entrez: 18024
UniProtKB: Q60795

Process Predictions
Disease Predictions

Nfe2l2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of cellular response to stress	GO:0080135	159	0.888
positive regulation of apoptotic process	GO:0043065	217	0.867
lymphocyte homeostasis	GO:0002260	64	0.819
response to chromate	GO:0046687	1	0.813
cellular ion homeostasis	GO:0006873	165	0.789
regulation of cellular amine metabolic process	GO:0033238	20	0.781
positive regulation of cell death	GO:0010942	224	0.737
metal ion homeostasis	GO:0055065	189	0.719
cellular response to inorganic substance	GO:0071241	37	0.710
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.709	Human
negative regulation of blood vessel endothelial cell migration	GO:0043537	3	0.706
myeloid cell homeostasis	GO:0002262	114	0.694	Mouse
leukocyte homeostasis	GO:0001776	79	0.690
intrinsic apoptotic signaling pathway	GO:0097193	132	0.669	Human
cation homeostasis	GO:0055080	212	0.662
response to extracellular stimulus	GO:0009991	127	0.658
lipid biosynthetic process	GO:0008610	179	0.621
nucleocytoplasmic transport	GO:0006913	139	0.602
cell type specific apoptotic process	GO:0097285	268	0.601	Human
blood coagulation	GO:0007596	76	0.600
positive regulation of apoptotic process involved in mammary gland involution	GO:0060058	4	0.591
cytokine production	GO:0001816	319	0.571
regulation of body fluid levels	GO:0050878	162	0.550
epidermis development	GO:0008544	187	0.543
response to nutrient levels	GO:0031667	109	0.537
regulation of response to wounding	GO:1903034	189	0.532
regulation of membrane potential	GO:0042391	192	0.531
zinc ion homeostasis	GO:0055069	10	0.522
leukocyte apoptotic process	GO:0071887	71	0.522
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.519
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.518
homeostasis of number of cells	GO:0048872	210	0.517	Mouse
glycerolipid biosynthetic process	GO:0045017	50	0.504
amine metabolic process	GO:0009308	45	0.501
negative regulation of neuron death	GO:1901215	98	0.497
cellular lipid metabolic process	GO:0044255	323	0.482
peptidyl amino acid modification	GO:0018193	336	0.478	Mouse
hemostasis	GO:0007599	78	0.474
regulation of cytokine production	GO:0001817	266	0.454
cellular response to dna damage stimulus	GO:0006974	207	0.448
lymphocyte mediated immunity	GO:0002449	139	0.446
cellular response to external stimulus	GO:0071496	88	0.416
regulation of leukocyte apoptotic process	GO:2000106	56	0.415
regulation of ion transport	GO:0043269	215	0.414
sphingolipid metabolic process	GO:0006665	45	0.414
neuron apoptotic process	GO:0051402	142	0.407
t cell apoptotic process	GO:0070231	39	0.406
response to inorganic substance	GO:0010035	96	0.404
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.397
positive regulation of protein kinase activity	GO:0045860	144	0.385
regulation of neuron apoptotic process	GO:0043523	122	0.381
apoptotic signaling pathway	GO:0097190	306	0.373	Human
myeloid leukocyte activation	GO:0002274	83	0.366
positive regulation of cytokine production	GO:0001819	174	0.365
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway	GO:1902176	4	0.362	Human
positive regulation of protein phosphorylation	GO:0001934	242	0.361
cellular zinc ion homeostasis	GO:0006882	9	0.359
neuron death	GO:0070997	154	0.353
regulation of kinase activity	GO:0043549	249	0.351
t cell differentiation in thymus	GO:0033077	77	0.351
ear development	GO:0043583	200	0.349
positive regulation of programmed cell death	GO:0043068	218	0.346
cellular response to antibiotic	GO:0071236	4	0.345
cellular protein catabolic process	GO:0044257	155	0.335	Human
single organism nuclear import	GO:1902593	95	0.334
regulation of apoptotic signaling pathway	GO:2001233	197	0.332	Human
stress response to metal ion	GO:0097501	3	0.331
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.318	Human
organophosphate biosynthetic process	GO:0090407	122	0.317
organonitrogen compound biosynthetic process	GO:1901566	192	0.316
cellular response to extracellular stimulus	GO:0031668	81	0.314
cellular response to radiation	GO:0071478	28	0.312
glial cell differentiation	GO:0010001	131	0.311
negative regulation of neuron apoptotic process	GO:0043524	92	0.307
regulation of protein kinase activity	GO:0045859	232	0.306
cellular amine metabolic process	GO:0044106	44	0.300
cellular response to cytokine stimulus	GO:0071345	189	0.299	Human
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.298
positive regulation of defense response	GO:0031349	124	0.295
digestive system development	GO:0055123	200	0.295	Fly
fibroblast proliferation	GO:0048144	35	0.291
positive regulation of extrinsic apoptotic signaling pathway	GO:2001238	34	0.289
maintenance of location	GO:0051235	89	0.288	Fly
response to organic cyclic compound	GO:0014070	198	0.287
coagulation	GO:0050817	78	0.282
response to reactive oxygen species	GO:0000302	56	0.281
response to drug	GO:0042493	75	0.270
cellular response to metal ion	GO:0071248	31	0.267
ion transmembrane transport	GO:0034220	361	0.267
inflammatory response to wounding	GO:0090594	4	0.261
mitochondrion organization	GO:0007005	134	0.255
negative regulation of growth	GO:0045926	99	0.254
lipid homeostasis	GO:0055088	63	0.253
positive regulation of glial cell proliferation	GO:0060252	4	0.246
developmental maturation	GO:0021700	193	0.245	Fly
defense response to other organism	GO:0098542	197	0.244
response to radiation	GO:0009314	165	0.243
membrane organization	GO:0061024	245	0.243
regulation of protein localization	GO:0032880	231	0.242
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest	GO:0006977	3	0.241
negative regulation of cytokine production	GO:0001818	84	0.239
divalent inorganic cation homeostasis	GO:0072507	138	0.239
defense response to bacterium	GO:0042742	119	0.237
apoptotic process involved in mammary gland involution	GO:0060057	4	0.234
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.229	Human
positive regulation of neuron apoptotic process	GO:0043525	25	0.228
nitric oxide mediated signal transduction	GO:0007263	4	0.226
protein lipid complex subunit organization	GO:0071825	12	0.223
keratinocyte migration	GO:0051546	3	0.221
phosphatidic acid metabolic process	GO:0046473	2	0.221
skin development	GO:0043588	220	0.220
regulation of ossification	GO:0030278	112	0.217	Mouse
positive regulation of mapk cascade	GO:0043410	170	0.216
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	57	0.215
organic anion transport	GO:0015711	137	0.215
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.214
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.212
protein catabolic process	GO:0030163	221	0.212	Human
positive regulation of intrinsic apoptotic signaling pathway	GO:2001244	25	0.208
phosphatidic acid biosynthetic process	GO:0006654	2	0.204
positive regulation of homeostatic process	GO:0032846	64	0.204
response to light stimulus	GO:0009416	135	0.202
granulocyte migration	GO:0097530	43	0.201
peptidyl serine modification	GO:0018209	83	0.200
epithelial cell proliferation	GO:0050673	174	0.196
intracellular receptor signaling pathway	GO:0030522	74	0.196
activation of cysteine type endopeptidase activity	GO:0097202	27	0.193
transmission of nerve impulse	GO:0019226	76	0.191
regulation of cellular response to oxidative stress	GO:1900407	19	0.191
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.190
cellular response to zinc ion	GO:0071294	3	0.189
glycerophospholipid biosynthetic process	GO:0046474	32	0.187
cellular chemical homeostasis	GO:0055082	215	0.187
mammary gland epithelium development	GO:0061180	65	0.184
myeloid cell differentiation	GO:0030099	233	0.183	Mouse
microtubule cytoskeleton organization	GO:0000226	157	0.182	Fly
regulation of peptidase activity	GO:0052547	96	0.181
b cell proliferation	GO:0042100	53	0.180
protein localization to nucleus	GO:0034504	121	0.180
anatomical structure homeostasis	GO:0060249	145	0.179
chemotaxis	GO:0006935	247	0.178
cytoplasmic transport	GO:0016482	234	0.177
cellular transition metal ion homeostasis	GO:0046916	32	0.176
positive regulation of organelle organization	GO:0010638	128	0.173
ubiquitin dependent protein catabolic process	GO:0006511	129	0.170	Human
urogenital system development	GO:0001655	261	0.168
cell maturation	GO:0048469	127	0.167	Fly
cellular amide metabolic process	GO:0043603	58	0.167
transition metal ion homeostasis	GO:0055076	54	0.167
regulation of cellular ketone metabolic process	GO:0010565	66	0.165
cellular response to abiotic stimulus	GO:0071214	56	0.163
regulation of lipid storage	GO:0010883	20	0.162
negative regulation of phosphorylation	GO:0042326	166	0.158
myeloid cell apoptotic process	GO:0033028	22	0.156
cellular homeostasis	GO:0019725	240	0.155
b cell activation	GO:0042113	161	0.155
response to peptide hormone	GO:0043434	127	0.154
response to endoplasmic reticulum stress	GO:0034976	53	0.154
protein localization to organelle	GO:0033365	185	0.153
regulation of peptidyl serine phosphorylation	GO:0033135	39	0.152
skeletal system development	GO:0001501	356	0.152
ribonucleotide metabolic process	GO:0009259	291	0.152
development of primary sexual characteristics	GO:0045137	143	0.151
response to oxidative stress	GO:0006979	123	0.150
positive regulation of kinase activity	GO:0033674	155	0.149
positive regulation of secretion by cell	GO:1903532	114	0.148
modification dependent macromolecule catabolic process	GO:0043632	133	0.148	Human
female sex differentiation	GO:0046660	84	0.146
regulation of transforming growth factor beta2 production	GO:0032909	2	0.145
dendrite development	GO:0016358	115	0.145	Fly
positive regulation of proteolysis	GO:0045862	85	0.144
regulation of establishment of protein localization	GO:0070201	181	0.144
g1 s transition of mitotic cell cycle	GO:0000082	57	0.143
cellular response to oxidative stress	GO:0034599	76	0.143
multicellular organismal aging	GO:0010259	24	0.143	Fly
regulation of transferase activity	GO:0051338	263	0.142
positive regulation of protein modification process	GO:0031401	299	0.142	Mouse
positive regulation of phagocytosis	GO:0050766	26	0.142
neuronal action potential	GO:0019228	54	0.141
development of primary female sexual characteristics	GO:0046545	73	0.140
response to steroid hormone	GO:0048545	56	0.139
modification by symbiont of host morphology or physiology	GO:0044003	4	0.139
triglyceride metabolic process	GO:0006641	51	0.135
lipid localization	GO:0010876	126	0.135
fertilization	GO:0009566	127	0.135
gonad development	GO:0008406	141	0.134
inflammatory response	GO:0006954	244	0.134
negative regulation of cell cycle	GO:0045786	123	0.133
regulation of lymphocyte apoptotic process	GO:0070228	41	0.132
regulation of hemostasis	GO:1900046	28	0.131
hypoxia inducible factor 1alpha signaling pathway	GO:0097411	2	0.131
regulation of neuron death	GO:1901214	134	0.130
action potential	GO:0001508	78	0.130
cellular response to toxic substance	GO:0097237	7	0.129
rhythmic process	GO:0048511	174	0.128
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.128
negative regulation of homeostatic process	GO:0032845	71	0.128
glycoprotein metabolic process	GO:0009100	116	0.126
negative regulation of protein metabolic process	GO:0051248	282	0.126
membrane lipid metabolic process	GO:0006643	53	0.125
signal transduction in absence of ligand	GO:0038034	55	0.124
gas homeostasis	GO:0033483	3	0.124
regulation of b cell activation	GO:0050864	81	0.124
regulation of cell cycle	GO:0051726	281	0.123
phospholipid biosynthetic process	GO:0008654	36	0.123
intrinsic apoptotic signaling pathway by p53 class mediator	GO:0072332	35	0.122
tissue homeostasis	GO:0001894	115	0.122
response to transition metal nanoparticle	GO:1990267	11	0.122
regulation of protein transport	GO:0051223	163	0.121
digestive tract morphogenesis	GO:0048546	147	0.121
striated muscle tissue development	GO:0014706	293	0.120
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.119
apoptotic mitochondrial changes	GO:0008637	48	0.118
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.118
negative regulation of interferon gamma mediated signaling pathway	GO:0060336	1	0.118
multicellular organismal homeostasis	GO:0048871	164	0.117
negative regulation of cellular amine metabolic process	GO:0033239	1	0.117
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.117
regulation of proteolysis	GO:0030162	164	0.117
regulation of blood coagulation	GO:0030193	28	0.116
negative regulation of inflammatory response to antigenic stimulus	GO:0002862	10	0.116
transmembrane transport	GO:0055085	412	0.115
regulation of lipid metabolic process	GO:0019216	118	0.115
regulation of vesicle mediated transport	GO:0060627	139	0.114
glycerolipid metabolic process	GO:0046486	122	0.114
regulation of cellular catabolic process	GO:0031329	242	0.113
fatty acid metabolic process	GO:0006631	121	0.112
nuclear import	GO:0051170	95	0.112
negative regulation of mapk cascade	GO:0043409	65	0.111
regulation of protein targeting	GO:1903533	61	0.111
spleen development	GO:0048536	39	0.111
regulation of acute inflammatory response	GO:0002673	27	0.111
respiratory tube development	GO:0030323	167	0.110
erythrocyte differentiation	GO:0030218	88	0.108	Mouse
regulation of cellular protein catabolic process	GO:1903362	61	0.108
regulation of inflammatory response	GO:0050727	147	0.107
muscle tissue development	GO:0060537	308	0.106
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.106
carbohydrate derivative biosynthetic process	GO:1901137	183	0.106
regulation of innate immune response	GO:0045088	91	0.105
regulation of cell activation	GO:0050865	289	0.105
gland development	GO:0048732	330	0.105
positive regulation of immune effector process	GO:0002699	107	0.105
response to low density lipoprotein particle	GO:0055098	2	0.104
cellular response to hormone stimulus	GO:0032870	150	0.104	Zebrafish
cation transport	GO:0006812	399	0.104
carboxylic acid transport	GO:0046942	100	0.103
regulation of cell cycle phase transition	GO:1901987	77	0.102
establishment of protein localization to organelle	GO:0072594	118	0.102
myelination	GO:0042552	74	0.102
mesenchyme development	GO:0060485	152	0.102
regulation of hydrolase activity	GO:0051336	246	0.101
regulation of ion homeostasis	GO:2000021	64	0.101
mapk cascade	GO:0000165	281	0.100
activation of mapkk activity	GO:0000186	15	0.099
protein acylation	GO:0043543	64	0.099	Mouse
positive regulation of cysteine type endopeptidase activity	GO:2001056	39	0.099
stress activated mapk cascade	GO:0051403	80	0.098
regulation of cell migration	GO:0030334	219	0.098
second messenger mediated signaling	GO:0019932	73	0.098
regulation of fibroblast proliferation	GO:0048145	34	0.097
extrinsic apoptotic signaling pathway	GO:0097191	126	0.097
lymphocyte differentiation	GO:0030098	242	0.095
myeloid leukocyte migration	GO:0097529	57	0.095
negative regulation of protein phosphorylation	GO:0001933	126	0.095
regulation of multi organism process	GO:0043900	111	0.095	Fly
branching morphogenesis of an epithelial tube	GO:0048754	159	0.095
sensory perception	GO:0007600	245	0.093
embryonic appendage morphogenesis	GO:0035113	126	0.093
organic acid transport	GO:0015849	101	0.093
oxidation reduction process	GO:0055114	342	0.092
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	31	0.091
negative regulation of immune system process	GO:0002683	209	0.091
signal transduction by p53 class mediator	GO:0072331	51	0.091
regulation of lymphocyte activation	GO:0051249	240	0.091
response to metal ion	GO:0010038	47	0.090
positive regulation of map kinase activity	GO:0043406	84	0.089
odontogenesis	GO:0042476	78	0.089
i kappab kinase nf kappab signaling	GO:0007249	85	0.088
positive regulation of lymphocyte activation	GO:0051251	140	0.088
digestive tract development	GO:0048565	190	0.087	Fly
mitochondrial membrane organization	GO:0007006	26	0.087
lipid storage	GO:0019915	36	0.087
positive regulation of apoptotic process involved in morphogenesis	GO:1902339	4	0.086
cytokine mediated signaling pathway	GO:0019221	115	0.086
negative regulation of cell growth	GO:0030308	44	0.086
dna metabolic process	GO:0006259	303	0.085
response to copper ion	GO:0046688	3	0.085
neuron maturation	GO:0042551	29	0.085
positive regulation of protein complex assembly	GO:0031334	45	0.085
response to lipopolysaccharide	GO:0032496	128	0.085
limb development	GO:0060173	166	0.085
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.085
cellular amino acid metabolic process	GO:0006520	103	0.084
innate immune response	GO:0045087	157	0.084
receptor biosynthetic process	GO:0032800	3	0.084
skin morphogenesis	GO:0043589	38	0.084
positive regulation of nervous system development	GO:0051962	221	0.083
regulation of nuclear division	GO:0051783	56	0.083
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.083	Human
wound healing	GO:0042060	157	0.082
b cell differentiation	GO:0030183	78	0.082
organelle fission	GO:0048285	170	0.081
b cell homeostasis	GO:0001782	34	0.081
regulation of homeostatic process	GO:0032844	182	0.081
positive regulation of mitochondrion organization	GO:0010822	17	0.081
regulation of mammary gland involution	GO:1903519	4	0.081
lipid transport	GO:0006869	98	0.080
kidney development	GO:0001822	213	0.080
wnt signaling pathway	GO:0016055	188	0.079
positive regulation of cellular catabolic process	GO:0031331	148	0.079
negative regulation of multi organism process	GO:0043901	68	0.079
negative regulation of cell proliferation	GO:0008285	296	0.079
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.078
skeletal muscle organ development	GO:0060538	163	0.078
embryonic placenta development	GO:0001892	98	0.077	Mouse
organelle localization	GO:0051640	179	0.077	Fly
cellular response to growth factor stimulus	GO:0071363	197	0.077
regulation of leukocyte mediated immunity	GO:0002703	104	0.076
stress activated protein kinase signaling cascade	GO:0031098	81	0.076
cellular response to ionizing radiation	GO:0071479	11	0.076
lactation	GO:0007595	25	0.076
response to oxygen radical	GO:0000305	16	0.076
regulation of endocytosis	GO:0030100	69	0.075
phospholipid metabolic process	GO:0006644	87	0.075
regulation of wnt signaling pathway	GO:0030111	123	0.075
regulation of mast cell differentiation	GO:0060375	3	0.075
protein modification by small protein conjugation	GO:0032446	187	0.074	Human
odontogenesis of dentin containing tooth	GO:0042475	66	0.074
cellular response to organic cyclic compound	GO:0071407	87	0.074
nucleoside phosphate metabolic process	GO:0006753	338	0.074
autophagy	GO:0006914	45	0.074
nucleoside phosphate biosynthetic process	GO:1901293	79	0.074
cellular response to light stimulus	GO:0071482	19	0.074
sensory perception of mechanical stimulus	GO:0050954	107	0.074
positive regulation of response to wounding	GO:1903036	66	0.074
response to ionizing radiation	GO:0010212	42	0.074
ensheathment of neurons	GO:0007272	76	0.073
multicellular organism growth	GO:0035264	161	0.073
rho protein signal transduction	GO:0007266	32	0.073
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.073
positive regulation of hydrolase activity	GO:0051345	148	0.073
response to starvation	GO:0042594	65	0.073
positive regulation of lymphocyte apoptotic process	GO:0070230	13	0.072
negative regulation of protein modification process	GO:0031400	163	0.072
microtubule based process	GO:0007017	236	0.072	Fly
modulation by virus of host morphology or physiology	GO:0019048	3	0.072
regulation of stress activated mapk cascade	GO:0032872	69	0.072
blastocyst development	GO:0001824	80	0.071
negative regulation of leukocyte proliferation	GO:0070664	46	0.071
response to hyperoxia	GO:0055093	2	0.071
regulation of defense response	GO:0031347	233	0.071
negative regulation of epithelial cell proliferation	GO:0050680	64	0.070
regulation of mitotic cell cycle	GO:0007346	126	0.070
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	34	0.069	Human
regulation of inflammatory response to antigenic stimulus	GO:0002861	21	0.069
cellular metal ion homeostasis	GO:0006875	151	0.069
regulation of protein complex assembly	GO:0043254	83	0.069
sensory perception of sound	GO:0007605	97	0.069
cellular response to nutrient levels	GO:0031669	64	0.069
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.069
positive regulation of neuron death	GO:1901216	28	0.069
positive regulation of interferon alpha production	GO:0032727	4	0.068
interspecies interaction between organisms	GO:0044419	83	0.068
leukocyte differentiation	GO:0002521	342	0.068
cellular response to starvation	GO:0009267	57	0.068
regulation of neuron differentiation	GO:0045664	281	0.068
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO:1902043	13	0.067
positive regulation of cell cycle	GO:0045787	92	0.067
regulation of organelle organization	GO:0033043	289	0.066
negative regulation of cellular protein metabolic process	GO:0032269	247	0.066
regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway	GO:1903376	3	0.066
regulation of protein serine threonine kinase activity	GO:0071900	157	0.066
cellular response to vitamin	GO:0071295	2	0.066
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	40	0.066
eye photoreceptor cell differentiation	GO:0001754	41	0.065
tissue migration	GO:0090130	68	0.065
protein import into nucleus	GO:0006606	95	0.065
multicellular organismal signaling	GO:0035637	91	0.065
purine nucleotide biosynthetic process	GO:0006164	65	0.065
negative regulation of lymphocyte apoptotic process	GO:0070229	24	0.065
epithelial tube morphogenesis	GO:0060562	303	0.064
actin filament organization	GO:0007015	113	0.064
hair follicle development	GO:0001942	85	0.064
positive regulation of myeloid cell differentiation	GO:0045639	43	0.064
regulation of b cell mediated immunity	GO:0002712	37	0.064
platelet activation	GO:0030168	40	0.063
negative regulation of nervous system development	GO:0051961	156	0.063
regulation of intracellular transport	GO:0032386	159	0.063
t cell activation	GO:0042110	289	0.063
regulation of cytoskeleton organization	GO:0051493	122	0.063
induction by organism of immune response of other organism involved in symbiotic interaction	GO:0052558	1	0.063
lymphocyte proliferation	GO:0046651	164	0.063
peptide metabolic process	GO:0006518	46	0.062
stem cell maintenance	GO:0019827	130	0.062
macrophage fusion	GO:0034238	3	0.062
negative regulation of inflammatory response	GO:0050728	61	0.062
glutamate metabolic process	GO:0006536	9	0.062
regulation of epithelial cell proliferation	GO:0050678	141	0.061
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.061
response to acid chemical	GO:0001101	111	0.061	Zebrafish
oxygen homeostasis	GO:0032364	2	0.061
reactive nitrogen species metabolic process	GO:2001057	0	0.060
regulation of cellular response to hypoxia	GO:1900037	2	0.060
intestinal absorption	GO:0050892	13	0.060
mammary gland morphogenesis	GO:0060443	54	0.060
male sex differentiation	GO:0046661	109	0.060
regulation of glutamine family amino acid metabolic process	GO:0000820	1	0.059
negative regulation of intracellular signal transduction	GO:1902532	167	0.059	Human
protein import	GO:0017038	101	0.059
purine ribonucleotide metabolic process	GO:0009150	290	0.058
immune response regulating signaling pathway	GO:0002764	125	0.058
glycerophospholipid metabolic process	GO:0006650	71	0.058
nucleotide biosynthetic process	GO:0009165	78	0.057
activation of immune response	GO:0002253	138	0.057
nucleoside monophosphate metabolic process	GO:0009123	85	0.057
protein oligomerization	GO:0051259	67	0.057
positive regulation of osteoclast differentiation	GO:0045672	15	0.057
organophosphate ester transport	GO:0015748	28	0.056
organic hydroxy compound transport	GO:0015850	93	0.056
immune effector process	GO:0002252	321	0.056
myeloid leukocyte differentiation	GO:0002573	119	0.055
intestinal epithelial structure maintenance	GO:0060729	4	0.055
regulation of lymphocyte mediated immunity	GO:0002706	84	0.055
release of cytochrome c from mitochondria	GO:0001836	23	0.055
acylglycerol metabolic process	GO:0006639	55	0.055
positive regulation of cellular component biogenesis	GO:0044089	94	0.055
regulation of myeloid cell apoptotic process	GO:0033032	19	0.055
acute inflammatory response	GO:0002526	41	0.054
positive regulation of secretion	GO:0051047	130	0.054
purine containing compound biosynthetic process	GO:0072522	70	0.054
positive regulation of innate immune response	GO:0045089	80	0.054
regulation of fat cell differentiation	GO:0045598	81	0.054
regulation of protein import into nucleus translocation	GO:0033158	2	0.053
regulation of fatty acid metabolic process	GO:0019217	28	0.053
regulation of calcium ion transport into cytosol	GO:0010522	31	0.053
organonitrogen compound catabolic process	GO:1901565	264	0.053
t cell homeostasis	GO:0043029	35	0.053
calcium ion homeostasis	GO:0055074	127	0.053
maternal process involved in female pregnancy	GO:0060135	32	0.052
positive regulation of leukocyte apoptotic process	GO:2000108	21	0.052
nuclear division	GO:0000280	158	0.052
positive regulation of peptidase activity	GO:0010952	49	0.052
cholesterol homeostasis	GO:0042632	44	0.051
cell adhesion	GO:0007155	329	0.051
embryonic limb morphogenesis	GO:0030326	126	0.051
negative regulation of endothelial cell migration	GO:0010596	4	0.051
anion transport	GO:0006820	177	0.051
positive regulation of phagocytosis engulfment	GO:0060100	3	0.051
regulation of organ morphogenesis	GO:2000027	144	0.051
response to interleukin 15	GO:0070672	3	0.051
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	56	0.051
cellular response to lipid	GO:0071396	145	0.051	Zebrafish
sensory organ morphogenesis	GO:0090596	242	0.051
cellular response to organonitrogen compound	GO:0071417	145	0.050
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.050
nucleobase containing small molecule metabolic process	GO:0055086	352	0.050
response to iron ion	GO:0010039	4	0.050
regulation of purine nucleotide metabolic process	GO:1900542	169	0.049
mast cell apoptotic process	GO:0033024	5	0.049
bone development	GO:0060348	120	0.049
glial cell apoptotic process	GO:0034349	3	0.049
regulation of nucleotide metabolic process	GO:0006140	169	0.049
positive regulation of lymphocyte proliferation	GO:0050671	70	0.048
macromolecule catabolic process	GO:0009057	281	0.048	Human
lung development	GO:0030324	164	0.048
positive regulation of gluconeogenesis	GO:0045722	11	0.048
regulation of leukocyte differentiation	GO:1902105	159	0.048
renal system development	GO:0072001	225	0.048
modification dependent protein catabolic process	GO:0019941	133	0.048	Human
negative regulation of mitotic cell cycle	GO:0045930	58	0.047
cell aging	GO:0007569	35	0.047
ras protein signal transduction	GO:0007265	77	0.047
cytokine biosynthetic process	GO:0042089	68	0.047
hair follicle morphogenesis	GO:0031069	29	0.047
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	36	0.047
mitochondrial transport	GO:0006839	36	0.047
positive regulation of adaptive immune response	GO:0002821	61	0.047
regulation of triglyceride biosynthetic process	GO:0010866	10	0.047
regulation of transmembrane transport	GO:0034762	128	0.047
intracellular protein transport	GO:0006886	204	0.047
positive regulation of dendrite development	GO:1900006	21	0.047

Nfe2l2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.356
inherited metabolic disorder	DOID:655	0.356
retinal disease	DOID:5679	0.268
sensory system disease	DOID:0050155	0.268
disease of anatomical entity	DOID:7	0.268
eye and adnexa disease	DOID:1492	0.268
nervous system disease	DOID:863	0.268
eye disease	DOID:5614	0.268
retinal degeneration	DOID:8466	0.198
immune system disease	DOID:2914	0.110
disease of cellular proliferation	DOID:14566	0.095
anemia	DOID:2355	0.070
hematopoietic system disease	DOID:74	0.070
integumentary system disease	DOID:16	0.057

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