Mus musculus

164 known processes

Gclc

glutamate-cysteine ligase, catalytic subunit

(Aliases: Glclc,Ggcs-hs,D9Wsu168e,GLCL-H)

Gclc biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
serine family amino acid metabolic processGO:000906970.995
Human
cellular amino acid biosynthetic processGO:0008652220.985
glutathione metabolic processGO:0006749160.965
cellular modified amino acid biosynthetic processGO:0042398120.946
glutathione biosynthetic processGO:000675040.941
regulation of membrane depolarizationGO:0003254110.886
cysteine metabolic processGO:000653430.778
Human
sulfur compound metabolic processGO:00067901000.760
peptide metabolic processGO:0006518460.749
organic acid biosynthetic processGO:0016053860.742
cellular amide metabolic processGO:0043603580.683
cellular modified amino acid metabolic processGO:0006575630.658
regulation of mitochondrial depolarizationGO:005190050.646
sulfur amino acid metabolic processGO:000009690.637
Human
cellular amino acid metabolic processGO:00065201030.619
mitochondrion organizationGO:00070051340.559
regulation of membrane potentialGO:00423911920.528
membrane depolarizationGO:0051899640.448
organonitrogen compound biosynthetic processGO:19015661920.440
regulation of mitochondrial membrane potentialGO:0051881170.426
apoptotic mitochondrial changesGO:0008637480.415
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237450.413
peptide biosynthetic processGO:0043043110.408
response to oxidative stressGO:00069791230.389
Human
small molecule biosynthetic processGO:00442831320.364
regulation of apoptotic signaling pathwayGO:20012331970.308
circulatory system processGO:00030131970.304
Human
extrinsic apoptotic signaling pathwayGO:00971911260.285
negative regulation of apoptotic signaling pathwayGO:20012341040.275
regulation of ion homeostasisGO:2000021640.268
regulation of homeostatic processGO:00328441820.260
vascular process in circulatory systemGO:0003018620.258
Human
regulation of blood vessel sizeGO:0050880560.256
Human
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.226
regulation of ligase activityGO:0051340100.208
regulation of anatomical structure sizeGO:00900661780.206
Human
regulation of tube sizeGO:0035150570.202
Human
cellular lipid metabolic processGO:00442553230.080
transmembrane transportGO:00550854120.074
amine metabolic processGO:0009308450.074
cellular amine metabolic processGO:0044106440.073
response to drugGO:0042493750.069
oxidation reduction processGO:00551143420.068
nucleobase containing small molecule metabolic processGO:00550863520.057
purine ribonucleotide metabolic processGO:00091502900.055
cellular ketone metabolic processGO:0042180840.053
purine nucleotide metabolic processGO:00061633020.049
nucleoside metabolic processGO:00091162460.049
cellular homeostasisGO:00197252400.048
Human
regulation of cellular amino acid metabolic processGO:000652150.046
ribonucleoside metabolic processGO:00091192450.044
organic cyclic compound catabolic processGO:19013612950.043
positive regulation of cellular amino acid metabolic processGO:004576430.042
anion transportGO:00068201770.040
ion transmembrane transportGO:00342203610.038
chromatin modificationGO:00165681870.038
cellular nitrogen compound catabolic processGO:00442702800.037
neural precursor cell proliferationGO:00613511210.037
regulation of cellular amine metabolic processGO:0033238200.037
ribonucleotide metabolic processGO:00092592910.037
histone modificationGO:00165701590.037
macromolecule methylationGO:00434141200.036
negative regulation of protein metabolic processGO:00512482820.036
chromatin organizationGO:00063252060.036
protein alkylationGO:0008213810.035
stem cell proliferationGO:00720891170.035
protein modification by small protein conjugation or removalGO:00706472070.035
carbohydrate derivative biosynthetic processGO:19011371830.035
organic hydroxy compound metabolic processGO:19016152030.035
nucleoside phosphate metabolic processGO:00067533380.035
skeletal system developmentGO:00015013560.034
ribose phosphate metabolic processGO:00196932910.033
methylationGO:00322591340.033
purine ribonucleoside metabolic processGO:00461282410.033
peptidyl amino acid modificationGO:00181933360.033
regulation of organelle organizationGO:00330432890.031
purine ribonucleoside catabolic processGO:00461302050.031
covalent chromatin modificationGO:00165691630.031
response to nutrient levelsGO:00316671090.030
spermatogenesisGO:00072832840.030
reactive oxygen species metabolic processGO:0072593840.030
heterocycle catabolic processGO:00467002800.030
regulation of nucleotide catabolic processGO:00308111220.030
rab protein signal transductionGO:003248210.030
cation transportGO:00068123990.030
organonitrogen compound catabolic processGO:19015652640.030
metal ion homeostasisGO:00550651890.029
response to extracellular stimulusGO:00099911270.029
purine containing compound metabolic processGO:00725213110.029
organophosphate catabolic processGO:00464342320.028
regulation of nucleotide metabolic processGO:00061401690.028
purine containing compound catabolic processGO:00725232130.028
forebrain developmentGO:00309003020.027
regulation of cellular catabolic processGO:00313292420.027
organic acid transportGO:00158491010.027
glycosyl compound catabolic processGO:19016582060.027
positive regulation of cellular catabolic processGO:00313311480.027
positive regulation of cellular amine metabolic processGO:003324050.027
regulation of cellular ketone metabolic processGO:0010565660.026
sphingolipid metabolic processGO:0006665450.026
glycosyl compound metabolic processGO:19016572460.026
gtp catabolic processGO:00061841430.026
cellular chemical homeostasisGO:00550822150.025
purine nucleoside triphosphate metabolic processGO:00091442260.025
apoptotic signaling pathwayGO:00971903060.025
protein ubiquitinationGO:00165671710.025
negative regulation of cellular protein metabolic processGO:00322692470.025
neuronal action potentialGO:0019228540.025
cellular response to dna damage stimulusGO:00069742070.025
positive regulation of gtpase activityGO:0043547850.025
purine nucleotide catabolic processGO:00061952110.024
response to inorganic substanceGO:0010035960.024
respiratory tube developmentGO:00303231670.023
action potentialGO:0001508780.023
organophosphate biosynthetic processGO:00904071220.023
proteasomal protein catabolic processGO:0010498980.023
male gamete generationGO:00482322850.023
maternal determination of anterior posterior axis embryoGO:000835820.023
posttranscriptional regulation of gene expressionGO:00106081550.023
membrane organizationGO:00610242450.023
axonogenesisGO:00074092740.022
anion transmembrane transportGO:0098656710.022
nucleoside phosphate catabolic processGO:19012922220.022
protein catabolic processGO:00301632210.022
nucleotide metabolic processGO:00091173320.022
regulation of purine nucleotide metabolic processGO:19005421690.022
carboxylic acid biosynthetic processGO:0046394860.022
oocyte constructionGO:000730820.022
ribonucleotide catabolic processGO:00092612080.021
organelle fissionGO:00482851700.021
negative regulation of cellular amino acid metabolic processGO:004576300.021
ras protein signal transductionGO:0007265770.021
epithelial tube morphogenesisGO:00605623030.021
cell type specific apoptotic processGO:00972852680.021
ribonucleoside triphosphate metabolic processGO:00091992200.021
respiratory system developmentGO:00605411900.021
positive regulation of cell developmentGO:00107202370.021
negative regulation of molecular functionGO:00440922580.020
positive regulation of nucleotide metabolic processGO:00459811140.020
negative regulation of cellular amine metabolic processGO:003323910.020
oocyte axis specificationGO:000730920.020
purine nucleoside catabolic processGO:00061522050.020
mrna metabolic processGO:0016071840.020
response to radiationGO:00093141650.020
microtubule based processGO:00070172360.020
cellular response to lipidGO:00713961450.020
compound eye developmentGO:004874910.020
membrane lipid biosynthetic processGO:0046467320.020
nucleotide catabolic processGO:00091662170.020
multicellular organismal homeostasisGO:00488711640.020
positive regulation of ras gtpase activityGO:0032320650.020
regulation of cytokine productionGO:00018172660.020
myeloid cell differentiationGO:00300992330.020
modification dependent protein catabolic processGO:00199411330.019
aromatic compound catabolic processGO:00194392860.019
protein methylationGO:0006479810.019
lung developmentGO:00303241640.019
cellular metal ion homeostasisGO:00068751510.019
purine ribonucleoside triphosphate catabolic processGO:00092071990.019
germ cell developmentGO:00072811850.019
response to light stimulusGO:00094161350.019
transmission of nerve impulseGO:0019226760.019
regulation of translationGO:0006417710.019
locomotory behaviorGO:00076261950.019
nucleoside catabolic processGO:00091642060.019
regulation of hydrolase activityGO:00513362460.019
carbohydrate derivative catabolic processGO:19011362310.019
regulation of reactive oxygen species metabolic processGO:2000377400.018
inorganic cation transmembrane transportGO:00986622070.018
regulation of transmembrane transportGO:00347621280.018
guanosine containing compound metabolic processGO:19010681440.018
pole plasm assemblyGO:000731520.018
multicellular organismal signalingGO:0035637910.018
divalent inorganic cation transportGO:00725111780.018
inorganic ion transmembrane transportGO:00986602340.018
nitrogen compound transportGO:00717052710.018
purine ribonucleotide catabolic processGO:00091542080.018
ribonucleoside catabolic processGO:00424542060.018
asymmetric stem cell divisionGO:009872230.018
cation homeostasisGO:00550802120.018
alpha amino acid metabolic processGO:1901605590.018
Human
actin cytoskeleton organizationGO:00300362200.018
sulfur compound biosynthetic processGO:0044272370.018
positive regulation of cell deathGO:00109422240.018
rna processingGO:00063961050.018
response to acid chemicalGO:00011011110.018
purine nucleoside metabolic processGO:00422782410.018
regulation of stem cell proliferationGO:0072091780.018
small gtpase mediated signal transductionGO:0007264970.017
cellular response to cytokine stimulusGO:00713451890.017
ubiquitin dependent protein catabolic processGO:00065111290.017
gland developmentGO:00487323300.017
ribonucleoside triphosphate catabolic processGO:00092031990.017
positive regulation of nervous system developmentGO:00519622210.017
positive regulation of apoptotic processGO:00430652170.017
positive regulation of nucleoside metabolic processGO:0045979910.017
chemotaxisGO:00069352470.017
glycoprotein metabolic processGO:00091001160.017
response to organonitrogen compoundGO:00102432460.017
positive regulation of purine nucleotide metabolic processGO:19005441140.016
nuclear transportGO:00511691390.016
regulation of purine nucleotide catabolic processGO:00331211220.016
renal system developmentGO:00720012250.016
cellular response to external stimulusGO:0071496880.016
regulation of cell cycleGO:00517262810.016
membrane lipid metabolic processGO:0006643530.016
phospholipid metabolic processGO:0006644870.016
carbohydrate metabolic processGO:00059752300.016
regulation of ion transmembrane transportGO:00347651190.016
cation transmembrane transportGO:00986552660.016
inflammatory responseGO:00069542440.016
regulation of ion transportGO:00432692150.016
intracellular protein transportGO:00068862040.016
establishment of protein localization to organelleGO:00725941180.016
macromolecule catabolic processGO:00090572810.016
blood circulationGO:00080151950.016
Human
divalent inorganic cation homeostasisGO:00725071380.016
regulation of gtp catabolic processGO:00331241130.015
nucleoside triphosphate metabolic processGO:00091412300.015
lipoprotein metabolic processGO:0042157430.015
negative regulation of transferase activityGO:0051348850.015
glucose homeostasisGO:00425931280.015
response to organic cyclic compoundGO:00140701980.015
protein localization to organelleGO:00333651850.015
regulation of neural precursor cell proliferationGO:2000177700.015
gtp metabolic processGO:00460391440.015
establishment or maintenance of cytoskeleton polarityGO:003095220.015
microtubule cytoskeleton organizationGO:00002261570.015
positive regulation of gtp catabolic processGO:0033126850.015
myeloid cell homeostasisGO:00022621140.015
cytokine productionGO:00018163190.015
cell maturationGO:00484691270.015
regulation of kinase activityGO:00435492490.015
modification dependent macromolecule catabolic processGO:00436321330.015
regulation of secretionGO:00510462740.015
regulation of nucleoside metabolic processGO:00091181300.015
regulation of hormone levelsGO:00108172110.015
rho protein signal transductionGO:0007266320.014
alcohol metabolic processGO:00060661160.014
sensory perceptionGO:00076002450.014
cellular protein complex assemblyGO:00436231160.014
lipid biosynthetic processGO:00086101790.014
anatomical structure homeostasisGO:00602491450.014
regulation of secretion by cellGO:19035302490.014
nucleoside triphosphate catabolic processGO:00091432050.014
neuron deathGO:00709971540.014
cellular divalent inorganic cation homeostasisGO:00725031270.014
regulation of protein kinase activityGO:00458592320.014
cellular ion homeostasisGO:00068731650.014
mapk cascadeGO:00001652810.014
camera type eye developmentGO:00430102660.014
intracellular mrna localizationGO:000829840.014
guanosine containing compound catabolic processGO:19010691440.014
negative regulation of cell proliferationGO:00082852960.014
purine nucleoside triphosphate catabolic processGO:00091462030.014
negative regulation of phosphorus metabolic processGO:00105631840.014
regulation of response to woundingGO:19030341890.014
ossificationGO:00015032160.014
regulation of neuron differentiationGO:00456642810.014
positive regulation of protein phosphorylationGO:00019342420.014
establishment or maintenance of microtubule cytoskeleton polarityGO:003095110.014
urogenital system developmentGO:00016552610.014
fat cell differentiationGO:00454441600.014
carbohydrate homeostasisGO:00335001280.014
regulation of protein localizationGO:00328802310.014
response to reactive oxygen speciesGO:0000302560.013
snrna processingGO:001618010.013
regulation of system processGO:00440572000.013
endomembrane system organizationGO:00102561470.013
innate immune responseGO:00450871570.013
regulation of lymphocyte activationGO:00512492400.013
glycerolipid metabolic processGO:00464861220.013
primary neural tube formationGO:0014020950.013
glycoprotein biosynthetic processGO:0009101890.013
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.013
dna endoreduplicationGO:004202340.013
carboxylic acid transportGO:00469421000.013
regulation of chromatin modificationGO:1903308570.013
hematopoietic progenitor cell differentiationGO:00022441430.013
morphogenesis of embryonic epitheliumGO:00163311590.013
regulation of cell activationGO:00508652890.013
monocarboxylic acid metabolic processGO:00327871910.013
regulation of cellular component sizeGO:00325351210.013
cytoplasmic transportGO:00164822340.013
digestive system developmentGO:00551232000.013
positive regulation of programmed cell deathGO:00430682180.013
organic hydroxy compound transportGO:0015850930.013
purine ribonucleoside triphosphate metabolic processGO:00092052200.013
nucleoside monophosphate metabolic processGO:0009123850.013
response to metal ionGO:0010038470.013
homeostasis of number of cellsGO:00488722100.013
negative regulation of protein phosphorylationGO:00019331260.013
regulation of inflammatory responseGO:00507271470.013
cognitionGO:00508901490.013
embryonic organ morphogenesisGO:00485622760.013
proteolysis involved in cellular protein catabolic processGO:00516031470.013
lipid transportGO:0006869980.013
placenta developmentGO:00018901400.013
cellular response to hormone stimulusGO:00328701500.012
response to uvGO:0009411440.012
leukocyte differentiationGO:00025213420.012
cellularizationGO:000734910.012
myelinationGO:0042552740.012
protein maturationGO:00516041760.012
bone developmentGO:00603481200.012
mitotic cell cycle processGO:19030471590.012
monocarboxylic acid transportGO:0015718440.012
striated muscle tissue developmentGO:00147062930.012
carbon catabolite activation of transcriptionGO:004599140.012
negative regulation of protein modification processGO:00314001630.012
positive regulation of secretionGO:00510471300.012
negative regulation of growthGO:0045926990.012
fertilizationGO:00095661270.012
regulation of ras protein signal transductionGO:00465781140.012
protein modification by small protein conjugationGO:00324461870.012
divalent metal ion transportGO:00708381720.012
muscle system processGO:00030121410.012
cofactor transportGO:005118140.012
oocyte anterior posterior axis specificationGO:000731420.012
ear developmentGO:00435832000.012
negative regulation of cellular component organizationGO:00511291940.012
positive regulation of reactive oxygen species metabolic processGO:2000379110.012
nucleocytoplasmic transportGO:00069131390.012
organ growthGO:00352651170.012
negative regulation of phosphate metabolic processGO:00459361840.012
dephosphorylationGO:00163111290.012
cellular response to acid chemicalGO:0071229680.012
immune effector processGO:00022523210.012
positive regulation of transferase activityGO:00513471670.012
regulation of cellular response to stressGO:00801351590.012
histone h3 k4 methylationGO:0051568230.012
regulation of body fluid levelsGO:00508781620.012
asymmetric neuroblast divisionGO:005505910.012
neutral lipid metabolic processGO:0006638570.011
multi multicellular organism processGO:00447061090.011
sensory organ morphogenesisGO:00905962420.011
lateral inhibitionGO:004633110.011
calcium ion homeostasisGO:00550741270.011
developmental maturationGO:00217001930.011
regulation of lipid metabolic processGO:00192161180.011
tube formationGO:00351481400.011
epithelial cell developmentGO:00020641590.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.011
wnt signaling pathwayGO:00160551880.011
heart processGO:0003015940.011
ear morphogenesisGO:00424711180.011
muscle tissue developmentGO:00605373080.011
transition metal ion homeostasisGO:0055076540.011
positive regulation of kinase activityGO:00336741550.011
development of primary sexual characteristicsGO:00451371430.011
nucleotide transmembrane transportGO:190167920.011
synaptic transmissionGO:00072683290.011
regulation of neuron deathGO:19012141340.011
cell adhesionGO:00071553290.011
positive regulation of protein modification processGO:00314012990.011
organic anion transportGO:00157111370.011
regulation of cellular component biogenesisGO:00440871810.011
epidermis developmentGO:00085441870.011
purine containing compound biosynthetic processGO:0072522700.011
cellular response to nutrient levelsGO:0031669640.011
organelle assemblyGO:00709251770.011
intrinsic apoptotic signaling pathwayGO:00971931320.011
snrna metabolic processGO:001607310.011
tube closureGO:0060606910.011
response to peptideGO:19016521360.011
positive regulation of purine nucleotide catabolic processGO:0033123880.011
skeletal muscle organ developmentGO:00605381630.011
regulation of ossificationGO:00302781120.011
positive regulation of nucleotide catabolic processGO:0030813880.011
single organism nuclear importGO:1902593950.011
negative regulation of mesenchymal cell proliferationGO:007220130.011
regulation of metal ion transportGO:00109591060.011
cellular response to extracellular stimulusGO:0031668810.011
i kappab kinase nf kappab signalingGO:0007249850.011
regulation of protein catabolic processGO:00421761080.011
purine ribonucleoside monophosphate metabolic processGO:0009167800.011
regulation of defense responseGO:00313472330.010
cardiac chamber developmentGO:00032051080.010
acylglycerol metabolic processGO:0006639550.010
sequestering of metal ionGO:0051238190.010
regulation of ras gtpase activityGO:0032318880.010
protein processingGO:00164851630.010
gonad developmentGO:00084061410.010
myeloid leukocyte differentiationGO:00025731190.010
negative regulation of phosphorylationGO:00423261660.010
skin developmentGO:00435882200.010
appendage developmentGO:00487361660.010
sphingolipid biosynthetic processGO:0030148260.010
response to endoplasmic reticulum stressGO:0034976530.010
response to oxygen radicalGO:0000305160.010
cellular macromolecule catabolic processGO:00442652060.010
limb morphogenesisGO:00351081490.010
dna repairGO:00062811070.010
mitotic cell cycleGO:00002781950.010
actin filament polymerizationGO:0030041440.010
positive regulation of homeostatic processGO:0032846640.010
ribonucleoside monophosphate metabolic processGO:0009161800.010
regulation of mitotic cell cycleGO:00073461260.010
production of molecular mediator of immune responseGO:00024401030.010
monosaccharide metabolic processGO:00059961060.010

Gclc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.032
inherited metabolic disorderDOID:65500.032
nervous system diseaseDOID:86300.017
disease of anatomical entityDOID:700.017
musculoskeletal system diseaseDOID:1700.016
disease of cellular proliferationDOID:1456600.015
cancerDOID:16200.015
organ system cancerDOID:005068600.015
bone diseaseDOID:008000100.013
connective tissue diseaseDOID:6500.013
immune system diseaseDOID:291400.012
hematopoietic system diseaseDOID:7400.012
eye and adnexa diseaseDOID:149200.011
sensory system diseaseDOID:005015500.011
eye diseaseDOID:561400.010