IMP: Integrative Multi-species Prediction

Mus musculus

31 known processes

Trim21

tripartite motif-containing 21

(Aliases: Ssa1,Ro52)

Entrez: 20821
Ensembl: ENSMUSG00000030966
UniProtKB: Q3UCL2
UniProtKB: Q3U7K7

Process Predictions
Disease Predictions

Trim21 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
defense response to other organism	GO:0098542	197	0.983
innate immune response	GO:0045087	157	0.971	Human Mouse
cellular response to interferon beta	GO:0035458	21	0.966
regulation of defense response	GO:0031347	233	0.939	Mouse
positive regulation of innate immune response	GO:0045089	80	0.938	Mouse
regulation of defense response to virus by host	GO:0050691	8	0.925
defense response to virus	GO:0051607	68	0.914
viral process	GO:0016032	41	0.898
response to interferon gamma	GO:0034341	34	0.848
defense response to protozoan	GO:0042832	25	0.829
immune effector process	GO:0002252	321	0.821
regulation of nlrp3 inflammasome complex assembly	GO:1900225	4	0.780	Mouse
innate immune response activating signal transduction	GO:0002758	50	0.775	Mouse
type i interferon production	GO:0032606	29	0.757
regulation of innate immune response	GO:0045088	91	0.757	Mouse
negative regulation of immune system process	GO:0002683	209	0.744	Mouse
interspecies interaction between organisms	GO:0044419	83	0.743
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.703
cellular response to lipopolysaccharide	GO:0071222	77	0.693
regulation of toll like receptor signaling pathway	GO:0034121	20	0.690	Mouse
regulation of defense response to virus	GO:0050688	18	0.689
cytokine production	GO:0001816	319	0.682	Mouse
response to protozoan	GO:0001562	28	0.664
pattern recognition receptor signaling pathway	GO:0002221	47	0.660	Mouse
cellular response to molecule of bacterial origin	GO:0071219	83	0.658
negative regulation of defense response to virus by host	GO:0050689	1	0.655
positive regulation of defense response	GO:0031349	124	0.649	Mouse
regulation of cytokine production	GO:0001817	266	0.645	Mouse
protein modification by small protein conjugation or removal	GO:0070647	207	0.629	Human Mouse
defense response to bacterium	GO:0042742	119	0.610
cellular response to interferon gamma	GO:0071346	25	0.608
negative regulation of nlrp3 inflammasome complex assembly	GO:1900226	2	0.599	Mouse
interferon beta production	GO:0032608	16	0.599
negative regulation of defense response	GO:0031348	77	0.596
protein modification by small protein conjugation	GO:0032446	187	0.590	Human Mouse
positive regulation of interferon alpha production	GO:0032727	4	0.587
cd8 positive alpha beta t cell proliferation	GO:0035740	1	0.581
leukocyte mediated cytotoxicity	GO:0001909	62	0.551
immune response regulating signaling pathway	GO:0002764	125	0.546	Mouse
cellular response to cytokine stimulus	GO:0071345	189	0.541
regulation of response to biotic stimulus	GO:0002831	38	0.537
positive regulation of type i interferon mediated signaling pathway	GO:0060340	4	0.535
negative regulation of cytokine production	GO:0001818	84	0.523	Mouse
positive regulation of viral genome replication	GO:0045070	2	0.515
positive regulation of rig i signaling pathway	GO:1900246	1	0.511
rig i signaling pathway	GO:0039529	4	0.510
immune response activating signal transduction	GO:0002757	116	0.482	Mouse
cellular response to type i interferon	GO:0071357	10	0.478
response to type i interferon	GO:0034340	12	0.476
toll like receptor signaling pathway	GO:0002224	38	0.471	Mouse
natural killer cell proliferation	GO:0001787	3	0.467
regulation of myd88 independent toll like receptor signaling pathway	GO:0034127	1	0.449
response to interferon beta	GO:0035456	22	0.442
regulation of interferon alpha production	GO:0032647	5	0.435
negative regulation of cell proliferation	GO:0008285	296	0.418
positive regulation of type i interferon production	GO:0032481	14	0.413
positive regulation of cytokine production	GO:0001819	174	0.412
activation of immune response	GO:0002253	138	0.406	Mouse
response to lipopolysaccharide	GO:0032496	128	0.405
response to molecule of bacterial origin	GO:0002237	143	0.396
viral life cycle	GO:0019058	36	0.396
regulation of type i interferon production	GO:0032479	22	0.390
schwann cell proliferation	GO:0014010	2	0.387
regulation of type i interferon mediated signaling pathway	GO:0060338	7	0.372
activation of innate immune response	GO:0002218	56	0.365	Mouse
i kappab kinase nf kappab signaling	GO:0007249	85	0.357
negative regulation of protein metabolic process	GO:0051248	282	0.353	Human
regulation of natural killer cell mediated cytotoxicity	GO:0042269	19	0.352
cellular response to lipid	GO:0071396	145	0.339
citrate metabolic process	GO:0006101	3	0.339
positive regulation of immune effector process	GO:0002699	107	0.338
cellular response to biotic stimulus	GO:0071216	92	0.325
type i interferon signaling pathway	GO:0060337	10	0.324
protein catabolic process	GO:0030163	221	0.313	Mouse
positive regulation of actin nucleation	GO:0051127	3	0.290	Mouse
regulation of cell activation	GO:0050865	289	0.286
negative regulation of multi organism process	GO:0043901	68	0.272	Human Mouse
positive regulation of natural killer cell mediated immunity	GO:0002717	16	0.272
negative regulation of nervous system development	GO:0051961	156	0.270	Mouse
cell killing	GO:0001906	67	0.268
lipopolysaccharide mediated signaling pathway	GO:0031663	25	0.261
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.254
erythrocyte differentiation	GO:0030218	88	0.248	Mouse
regulation of cytokine biosynthetic process	GO:0042035	59	0.246
positive regulation of cytokine biosynthetic process	GO:0042108	40	0.243
aromatic compound catabolic process	GO:0019439	286	0.242
mast cell proliferation	GO:0070662	4	0.235
protein ubiquitination	GO:0016567	171	0.231	Human Mouse
regulation of myd88 dependent toll like receptor signaling pathway	GO:0034124	2	0.227
cd4 positive alpha beta t cell differentiation involved in immune response	GO:0002294	28	0.227
b cell activation	GO:0042113	161	0.226
response to dsrna	GO:0043331	30	0.225
leukocyte mediated immunity	GO:0002443	174	0.220
negative regulation of toll like receptor signaling pathway	GO:0034122	14	0.220	Mouse
cellular macromolecule catabolic process	GO:0044265	206	0.218
regulation of interferon beta production	GO:0032648	13	0.216
gene silencing by mirna	GO:0035195	10	0.209
negative regulation of viral process	GO:0048525	23	0.206	Human Mouse
regulation of rig i signaling pathway	GO:0039535	2	0.205
regulation of adaptive immune response	GO:0002819	90	0.204
regulation of cell cycle	GO:0051726	281	0.204	Human
dna metabolic process	GO:0006259	303	0.204
entry into cell of other organism involved in symbiotic interaction	GO:0051806	15	0.197
regulation of natural killer cell differentiation	GO:0032823	11	0.196
regulation of lymphocyte activation	GO:0051249	240	0.195
t cell differentiation	GO:0030217	174	0.193
regulation of lymphocyte proliferation	GO:0050670	117	0.191
regulation of interferon gamma production	GO:0032649	57	0.190
regulation of b cell activation	GO:0050864	81	0.187
regulation of interferon beta biosynthetic process	GO:0045357	4	0.186
regulation of cd8 positive alpha beta t cell proliferation	GO:2000564	1	0.186
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	61	0.185
lymphocyte proliferation	GO:0046651	164	0.184
organic cyclic compound catabolic process	GO:1901361	295	0.181
cellular response to dna damage stimulus	GO:0006974	207	0.181
alpha beta t cell differentiation involved in immune response	GO:0002293	30	0.179
myeloid cell differentiation	GO:0030099	233	0.178	Mouse
cytoplasmic transport	GO:0016482	234	0.171
regulation of symbiosis encompassing mutualism through parasitism	GO:0043903	52	0.169
adaptive immune response	GO:0002250	155	0.169
protein import	GO:0017038	101	0.165
intracellular protein transport	GO:0006886	204	0.164
reactive oxygen species metabolic process	GO:0072593	84	0.162	Mouse
lymphocyte differentiation	GO:0030098	242	0.157
glycosyl compound metabolic process	GO:1901657	246	0.157
negative regulation of immune effector process	GO:0002698	55	0.156
myeloid cell homeostasis	GO:0002262	114	0.155	Mouse
regulation of mast cell proliferation	GO:0070666	4	0.155
regulation of lymphocyte mediated immunity	GO:0002706	84	0.154
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	68	0.154	Human
b cell activation involved in immune response	GO:0002312	50	0.153
natural killer cell mediated cytotoxicity	GO:0042267	29	0.151
cell fate commitment	GO:0045165	210	0.151
jak stat cascade involved in growth hormone signaling pathway	GO:0060397	4	0.151
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.151
positive regulation of cell activation	GO:0050867	158	0.151
cell activation involved in immune response	GO:0002263	126	0.149
progesterone metabolic process	GO:0042448	4	0.147
t cell activation	GO:0042110	289	0.146
leukocyte proliferation	GO:0070661	172	0.145
negative regulation of cell development	GO:0010721	169	0.144	Mouse
defense response to gram negative bacterium	GO:0050829	28	0.143
leukocyte differentiation	GO:0002521	342	0.141
somatic cell dna recombination	GO:0016444	51	0.139
negative regulation of protein modification process	GO:0031400	163	0.138	Human
response to granulocyte macrophage colony stimulating factor	GO:0097012	3	0.138
cytokine biosynthetic process	GO:0042089	68	0.138
purine ribonucleotide catabolic process	GO:0009154	208	0.137
creatinine metabolic process	GO:0046449	3	0.136
positive regulation of interferon beta production	GO:0032728	8	0.136
regulation of leukocyte differentiation	GO:1902105	159	0.135
natural killer cell activation	GO:0030101	44	0.134
regulation of t cell activation	GO:0050863	170	0.130
cytoplasmic pattern recognition receptor signaling pathway in response to virus	GO:0039528	4	0.130
negative regulation of cellular protein metabolic process	GO:0032269	247	0.129	Human
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.129	Mouse
alpha beta t cell activation involved in immune response	GO:0002287	31	0.129
nucleocytoplasmic transport	GO:0006913	139	0.125
activation of cysteine type endopeptidase activity	GO:0097202	27	0.123
interaction with host	GO:0051701	22	0.122
cd4 positive alpha beta t cell lineage commitment	GO:0043373	6	0.122
positive regulation of peptidase activity	GO:0010952	49	0.121
taurine metabolic process	GO:0019530	4	0.120
cytokine metabolic process	GO:0042107	71	0.119
development of secondary male sexual characteristics	GO:0046544	3	0.118
positive regulation of proteolysis	GO:0045862	85	0.118
viral genome replication	GO:0019079	17	0.118
positive regulation of t cell mediated cytotoxicity	GO:0001916	15	0.115
leukocyte activation involved in immune response	GO:0002366	126	0.113
regulation of mast cell differentiation	GO:0060375	3	0.113
nucleotide catabolic process	GO:0009166	217	0.112
cellular nitrogen compound catabolic process	GO:0044270	280	0.111
negative regulation of phosphate metabolic process	GO:0045936	184	0.110
lymphocyte mediated immunity	GO:0002449	139	0.110
positive regulation of response to cytokine stimulus	GO:0060760	11	0.109
glycosyl compound catabolic process	GO:1901658	206	0.108
positive t cell selection	GO:0043368	23	0.108
myeloid leukocyte differentiation	GO:0002573	119	0.108
production of molecular mediator of immune response	GO:0002440	103	0.107
cellular response to interferon alpha	GO:0035457	4	0.106
regulation of interleukin 2 production	GO:0032663	28	0.106
nucleotide metabolic process	GO:0009117	332	0.105
protein maturation	GO:0051604	176	0.105
positive regulation of cysteine type endopeptidase activity	GO:2001056	39	0.105
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.104
positive regulation of lymphocyte differentiation	GO:0045621	61	0.104
response to organic cyclic compound	GO:0014070	198	0.104
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.103
ribonucleotide metabolic process	GO:0009259	291	0.103
cellular amino acid metabolic process	GO:0006520	103	0.102
regulation of leukocyte proliferation	GO:0070663	121	0.102
regulation of natural killer cell activation	GO:0032814	22	0.101
positive regulation of natural killer cell mediated cytotoxicity	GO:0045954	16	0.100
regulation of t cell differentiation	GO:0045580	83	0.100
creatine metabolic process	GO:0006600	4	0.099
somatic recombination of immunoglobulin gene segments	GO:0016447	42	0.097
t helper cell differentiation	GO:0042093	28	0.096
regulation of viral release from host cell	GO:1902186	6	0.096	Human Mouse
ribose phosphate metabolic process	GO:0019693	291	0.096
macromolecule catabolic process	GO:0009057	281	0.096	Mouse
negative regulation of t cell activation	GO:0050868	65	0.095
organophosphate catabolic process	GO:0046434	232	0.094
protein processing	GO:0016485	163	0.094
regulation of leukocyte apoptotic process	GO:2000106	56	0.094
valine metabolic process	GO:0006573	4	0.094
natural killer cell mediated immunity	GO:0002228	29	0.093
immunoglobulin mediated immune response	GO:0016064	69	0.093
lymphocyte activation involved in immune response	GO:0002285	93	0.092
regulation of multi organism process	GO:0043900	111	0.092
nucleoside phosphate metabolic process	GO:0006753	338	0.092
negative regulation of cell activation	GO:0050866	111	0.091
nucleobase containing small molecule metabolic process	GO:0055086	352	0.091
regulation of lymphocyte differentiation	GO:0045619	107	0.090
myd88 independent toll like receptor signaling pathway	GO:0002756	3	0.090
regulation of endopeptidase activity	GO:0052548	89	0.090
t cell lineage commitment	GO:0002360	13	0.089
positive regulation of endopeptidase activity	GO:0010950	43	0.088
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.088
protein methylation	GO:0006479	81	0.087
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.086
nucleoside triphosphate metabolic process	GO:0009141	230	0.085
regulation of viral genome replication	GO:0045069	13	0.085
somatic recombination of immunoglobulin genes involved in immune response	GO:0002204	36	0.084
purine nucleoside metabolic process	GO:0042278	241	0.084
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.084
isotype switching	GO:0045190	36	0.084
viral gene expression	GO:0019080	3	0.084	Human Mouse
nucleoside metabolic process	GO:0009116	246	0.084
t helper 17 cell lineage commitment	GO:0072540	4	0.083
protein localization to nucleus	GO:0034504	121	0.083
purine nucleoside catabolic process	GO:0006152	205	0.083
t helper 1 cell lineage commitment	GO:0002296	2	0.083
regulation of leukocyte mediated cytotoxicity	GO:0001910	38	0.082
positive regulation of adaptive immune response	GO:0002821	61	0.081
cd4 positive alpha beta t cell activation	GO:0035710	45	0.081
positive regulation of leukocyte mediated cytotoxicity	GO:0001912	31	0.079
necrotic cell death	GO:0070265	30	0.079
regulation of cell motility	GO:2000145	236	0.078
mda 5 signaling pathway	GO:0039530	1	0.078
negative regulation of interferon beta production	GO:0032688	3	0.078
antigen processing and presentation of peptide antigen	GO:0048002	29	0.077
alpha beta t cell activation	GO:0046631	91	0.077
purine containing compound catabolic process	GO:0072523	213	0.077
interleukin 2 biosynthetic process	GO:0042094	15	0.077
positive regulation of apoptotic process	GO:0043065	217	0.077
regulation of proteolysis	GO:0030162	164	0.076
regulation of b cell differentiation	GO:0045577	23	0.076
extrinsic apoptotic signaling pathway	GO:0097191	126	0.075
protein polyubiquitination	GO:0000209	33	0.075	Human
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.074
positive regulation of viral entry into host cell	GO:0046598	3	0.074
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	36	0.074
regulation of defense response to bacterium	GO:1900424	3	0.074
positive regulation of leukocyte differentiation	GO:1902107	86	0.074
somatic diversification of immunoglobulins involved in immune response	GO:0002208	36	0.073
t cell proliferation	GO:0042098	120	0.073
regulation of macrophage fusion	GO:0034239	3	0.072
cd4 positive alpha beta t cell differentiation	GO:0043367	41	0.072
defense response to gram positive bacterium	GO:0050830	50	0.072
alpha beta t cell differentiation	GO:0046632	69	0.070
gamma delta t cell differentiation	GO:0042492	11	0.070
regulation of hormone levels	GO:0010817	211	0.070
response to interleukin 2	GO:0070669	2	0.070
nucleoside phosphate catabolic process	GO:1901292	222	0.069
multicellular organismal homeostasis	GO:0048871	164	0.069
t cell selection	GO:0045058	34	0.069
negative regulation of phosphorylation	GO:0042326	166	0.068
regulation of alpha beta t cell proliferation	GO:0046640	18	0.068
fatty acid metabolic process	GO:0006631	121	0.068
response to interleukin 15	GO:0070672	3	0.068
negative regulation of molecular function	GO:0044092	258	0.068	Human
positive regulation of programmed cell death	GO:0043068	218	0.067
cytokine mediated signaling pathway	GO:0019221	115	0.067
regulation of peptidase activity	GO:0052547	96	0.067
dicarboxylic acid metabolic process	GO:0043648	18	0.066
autophagy	GO:0006914	45	0.066
male sex differentiation	GO:0046661	109	0.066
regulation of b cell mediated immunity	GO:0002712	37	0.066
entry into host cell	GO:0030260	15	0.064
negative regulation of cellular component organization	GO:0051129	194	0.064	Mouse
regulation of inflammatory response	GO:0050727	147	0.064
positive regulation of leukocyte mediated immunity	GO:0002705	70	0.064
regulation of interleukin 2 biosynthetic process	GO:0045076	13	0.063
alpha amino acid metabolic process	GO:1901605	59	0.063
development of primary female sexual characteristics	GO:0046545	73	0.063
apoptotic signaling pathway	GO:0097190	306	0.063
somatic diversification of immune receptors	GO:0002200	53	0.062
protein import into nucleus	GO:0006606	95	0.062
negative regulation of glycolytic process	GO:0045820	4	0.062
cellular response to granulocyte macrophage colony stimulating factor stimulus	GO:0097011	3	0.062
regulation of response to wounding	GO:1903034	189	0.061
positive regulation of cell killing	GO:0031343	33	0.061
regulation of natural killer cell mediated immunity	GO:0002715	19	0.061
regulation of erythrocyte differentiation	GO:0045646	23	0.061
mitotic cell cycle	GO:0000278	195	0.061
regulation of cellular catabolic process	GO:0031329	242	0.061
organonitrogen compound catabolic process	GO:1901565	264	0.059
macromolecule methylation	GO:0043414	120	0.059
interleukin 2 production	GO:0032623	33	0.059
negative regulation of defense response to virus	GO:0050687	6	0.059
dna recombination	GO:0006310	92	0.059
purine ribonucleotide metabolic process	GO:0009150	290	0.058
syncytium formation	GO:0006949	43	0.058
peptidyl amino acid modification	GO:0018193	336	0.058
immunoglobulin production	GO:0002377	73	0.058
regulation of hydrolase activity	GO:0051336	246	0.058
negative regulation of phosphorus metabolic process	GO:0010563	184	0.057
positive regulation of myeloid leukocyte differentiation	GO:0002763	26	0.057
covalent chromatin modification	GO:0016569	163	0.057
ribonucleoside metabolic process	GO:0009119	245	0.057
negative regulation of viral release from host cell	GO:1902187	6	0.056	Human Mouse
ubiquitin dependent protein catabolic process	GO:0006511	129	0.056
modulation of molecular function in other organism	GO:0044359	1	0.056
response to growth factor	GO:0070848	198	0.055
chromatin organization	GO:0006325	206	0.055
interferon gamma mediated signaling pathway	GO:0060333	5	0.055
negative regulation of innate immune response	GO:0045824	17	0.055
regulation of activated t cell proliferation	GO:0046006	16	0.055
response to organonitrogen compound	GO:0010243	246	0.055
stem cell development	GO:0048864	219	0.055
cellular amide metabolic process	GO:0043603	58	0.055
cellular protein catabolic process	GO:0044257	155	0.054
programmed necrotic cell death	GO:0097300	28	0.054
purine nucleotide metabolic process	GO:0006163	302	0.054
positive regulation of lymphocyte mediated immunity	GO:0002708	62	0.054
t cell differentiation involved in immune response	GO:0002292	30	0.054
homeostasis of number of cells	GO:0048872	210	0.054	Mouse
positive regulation of lymphocyte activation	GO:0051251	140	0.053
epidermis development	GO:0008544	187	0.053
modification dependent macromolecule catabolic process	GO:0043632	133	0.053
positive regulation of mapk cascade	GO:0043410	170	0.052
adhesion of symbiont to host	GO:0044406	8	0.052
modification dependent protein catabolic process	GO:0019941	133	0.052
t cell activation involved in immune response	GO:0002286	43	0.052
regulation of cd8 positive alpha beta t cell activation	GO:2001185	3	0.051
generation of precursor metabolites and energy	GO:0006091	103	0.051
negative regulation of lymphocyte activation	GO:0051250	91	0.051
antibacterial peptide production	GO:0002778	2	0.051
negative regulation of viral transcription	GO:0032897	3	0.051	Human Mouse
leukocyte apoptotic process	GO:0071887	71	0.050
cd4 positive or cd8 positive alpha beta t cell lineage commitment	GO:0043369	8	0.050
interferon alpha production	GO:0032607	7	0.050
t cell differentiation in thymus	GO:0033077	77	0.050
hematopoietic progenitor cell differentiation	GO:0002244	143	0.050
nucleoside catabolic process	GO:0009164	206	0.050
glial cell differentiation	GO:0010001	131	0.050
negative regulation of interferon alpha production	GO:0032687	1	0.050
purine nucleotide catabolic process	GO:0006195	211	0.049
mammary gland epithelium development	GO:0061180	65	0.049
cell type specific apoptotic process	GO:0097285	268	0.049
b cell mediated immunity	GO:0019724	71	0.048
negative regulation of viral entry into host cell	GO:0046597	10	0.048	Mouse
skin development	GO:0043588	220	0.048
nucleoside triphosphate catabolic process	GO:0009143	205	0.048
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.048
syncytium formation by plasma membrane fusion	GO:0000768	42	0.048
nuclear import	GO:0051170	95	0.048
positive regulation of gamma delta t cell differentiation	GO:0045588	6	0.048
positive regulation of mast cell differentiation	GO:0060376	1	0.048
temperature homeostasis	GO:0001659	26	0.047
stem cell differentiation	GO:0048863	268	0.047
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	27	0.047
regulation of t cell proliferation	GO:0042129	92	0.047
regulation of protein ubiquitination	GO:0031396	52	0.046
gene silencing by rna	GO:0031047	19	0.046
production of small rna involved in gene silencing by rna	GO:0070918	6	0.046
regulation of protein transport	GO:0051223	163	0.046
gland development	GO:0048732	330	0.045
positive regulation of natural killer cell activation	GO:0032816	15	0.045
macrophage fusion	GO:0034238	3	0.045
stem cell maintenance	GO:0019827	130	0.045
positive regulation of response to wounding	GO:1903036	66	0.045
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.044
isoleucine metabolic process	GO:0006549	4	0.044
peptidyl lysine methylation	GO:0018022	29	0.044
regulation of intracellular transport	GO:0032386	159	0.044
regulation of intracellular protein transport	GO:0033157	82	0.044
positive regulation of b cell activation	GO:0050871	49	0.044
regulation of interleukin 1 alpha production	GO:0032650	4	0.043
posttranscriptional regulation of gene expression	GO:0010608	155	0.043	Human
negative regulation of intracellular signal transduction	GO:1902532	167	0.043
hair follicle development	GO:0001942	85	0.043
alpha beta t cell lineage commitment	GO:0002363	7	0.043
positive regulation of cellular component biogenesis	GO:0044089	94	0.043	Mouse
carbohydrate metabolic process	GO:0005975	230	0.042
positive regulation of hydrolase activity	GO:0051345	148	0.042
positive regulation of cell death	GO:0010942	224	0.042
nlrp3 inflammasome complex assembly	GO:0044546	5	0.042	Mouse
regulation of leukocyte mediated immunity	GO:0002703	104	0.041
regulation of autophagy	GO:0010506	30	0.041
isotype switching to ige isotypes	GO:0048289	7	0.041
positive regulation of interferon gamma production	GO:0032729	39	0.041
regulation of natural killer cell proliferation	GO:0032817	2	0.041
entry into other organism involved in symbiotic interaction	GO:0051828	15	0.040
interleukin 4 mediated signaling pathway	GO:0035771	2	0.040
cellular ketone metabolic process	GO:0042180	84	0.040
myd88 dependent toll like receptor signaling pathway	GO:0002755	7	0.040
peptidyl tyrosine modification	GO:0018212	145	0.040
leukocyte homeostasis	GO:0001776	79	0.039
positive regulation of interleukin 2 biosynthetic process	GO:0045086	8	0.039
regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway	GO:0039531	2	0.039
response to peptide hormone	GO:0043434	127	0.039
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.039	Human
regulation of type 2 immune response	GO:0002828	18	0.039
negative regulation of protein phosphorylation	GO:0001933	126	0.038
peptidyl tyrosine phosphorylation	GO:0018108	143	0.038
positive regulation of production of molecular mediator of immune response	GO:0002702	45	0.038
gliogenesis	GO:0042063	141	0.038
allantoin metabolic process	GO:0000255	3	0.038
t cell mediated cytotoxicity	GO:0001913	26	0.038
heterocycle catabolic process	GO:0046700	280	0.038
germ cell development	GO:0007281	185	0.038
pyroptosis	GO:0070269	8	0.038
ribonucleoside catabolic process	GO:0042454	206	0.038
positive regulation of leukocyte proliferation	GO:0070665	73	0.038
epithelial cell proliferation	GO:0050673	174	0.037
cytoplasmic pattern recognition receptor signaling pathway	GO:0002753	10	0.037
tumor necrosis factor production	GO:0032640	50	0.037	Mouse
natural killer cell differentiation	GO:0001779	21	0.037
protein targeting	GO:0006605	143	0.037
regulation of myeloid cell differentiation	GO:0045637	96	0.037
negative regulation of type 2 immune response	GO:0002829	8	0.036
cellular lipid metabolic process	GO:0044255	323	0.036
female sex differentiation	GO:0046660	84	0.036
tumor necrosis factor superfamily cytokine production	GO:0071706	51	0.036	Mouse
regulation of immunoglobulin production	GO:0002637	42	0.036
negative regulation of angiogenesis	GO:0016525	25	0.036
b cell differentiation	GO:0030183	78	0.036
regulation of mapk cascade	GO:0043408	248	0.036
hair follicle cell proliferation	GO:0071335	3	0.036
lymphocyte homeostasis	GO:0002260	64	0.036
regulation of interleukin 6 production	GO:0032675	55	0.035	Mouse
development of primary sexual characteristics	GO:0045137	143	0.035
positive regulation of interleukin 1 alpha secretion	GO:0050717	3	0.035
interferon gamma production	GO:0032609	67	0.034
negative regulation of macrophage fusion	GO:0034240	1	0.034
positive regulation of b cell differentiation	GO:0045579	13	0.034
purine ribonucleoside metabolic process	GO:0046128	241	0.034
multicellular organism growth	GO:0035264	161	0.034
cellular lactam metabolic process	GO:0072338	3	0.034
negative regulation of t cell differentiation	GO:0045581	23	0.034
gene silencing	GO:0016458	38	0.034
epithelial tube formation	GO:0072175	130	0.034
regulation of gamma delta t cell activation	GO:0046643	9	0.033
t cell homeostasis	GO:0043029	35	0.033
regulation of dna recombination	GO:0000018	34	0.033
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.033
ribonucleotide catabolic process	GO:0009261	208	0.033
cell adhesion	GO:0007155	329	0.033
methylation	GO:0032259	134	0.033
tricarboxylic acid metabolic process	GO:0072350	5	0.032
regulation of mitotic cell cycle	GO:0007346	126	0.032
positive regulation of interleukin 2 production	GO:0032743	19	0.032
regulation of protein localization	GO:0032880	231	0.032
carbohydrate derivative catabolic process	GO:1901136	231	0.032
blood vessel morphogenesis	GO:0048514	285	0.032
negative regulation of regulatory t cell differentiation	GO:0045590	2	0.032
positive regulation of myeloid cell differentiation	GO:0045639	43	0.032
regulation of transferase activity	GO:0051338	263	0.031
mucosal associated lymphoid tissue development	GO:0048537	12	0.031
gtp metabolic process	GO:0046039	144	0.031
entry into host	GO:0044409	15	0.031
alpha beta t cell proliferation	GO:0046633	21	0.031
regulation of syncytium formation by plasma membrane fusion	GO:0060142	23	0.031
regulation of homeostatic process	GO:0032844	182	0.031
lipid localization	GO:0010876	126	0.031
monocarboxylic acid metabolic process	GO:0032787	191	0.031
negative regulation of vasculature development	GO:1901343	26	0.031
positive regulation of myelination	GO:0031643	5	0.030
regulation of cell killing	GO:0031341	40	0.030
positive regulation of t cell activation	GO:0050870	101	0.030
negative regulation of rig i signaling pathway	GO:0039536	2	0.030
somatic diversification of immunoglobulins	GO:0016445	43	0.030
regulation of angiogenesis	GO:0045765	81	0.030
neuron migration	GO:0001764	122	0.029
protein localization to organelle	GO:0033365	185	0.029
regulation of glycolytic process	GO:0006110	10	0.029
t helper 1 type immune response	GO:0042088	25	0.029
regulation of myeloid leukocyte differentiation	GO:0002761	58	0.029
purine containing compound metabolic process	GO:0072521	311	0.029
establishment of protein localization to organelle	GO:0072594	118	0.029
response to peptide	GO:1901652	136	0.029
positive regulation of inflammatory response	GO:0050729	47	0.029
histone acetylation	GO:0016573	41	0.029
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.029
regulation of protein complex assembly	GO:0043254	83	0.029	Mouse
photoreceptor cell differentiation	GO:0046530	52	0.029
gamma delta t cell activation	GO:0046629	13	0.029
toll like receptor 7 signaling pathway	GO:0034154	4	0.028
steroid metabolic process	GO:0008202	119	0.028
interferon beta biosynthetic process	GO:0045350	4	0.028
cellular response to organic cyclic compound	GO:0071407	87	0.028

Trim21 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.052
cancer	DOID:162	0.052
organ system cancer	DOID:0050686	0.052
gastrointestinal system cancer	DOID:3119	0.052

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