IMP: Integrative Multi-species Prediction

Mus musculus

55 known processes

Vamp4

vesicle-associated membrane protein 4

(Aliases: D1Ertd147e)

Entrez: 53330
Ensembl: ENSMUSG00000026696
UniProtKB: O70480
UniProtKB: Q8BSN6

Process Predictions
Disease Predictions

Vamp4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
synaptic transmission	GO:0007268	329	0.278
regulation of cellular catabolic process	GO:0031329	242	0.195
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.178
purine ribonucleotide metabolic process	GO:0009150	290	0.162
guanosine containing compound metabolic process	GO:1901068	144	0.142
melanosome localization	GO:0032400	12	0.139
exocytosis	GO:0006887	121	0.138	Yeast
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.132
nucleoside phosphate metabolic process	GO:0006753	338	0.130
ribonucleoside metabolic process	GO:0009119	245	0.129
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.119
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.111
ribose phosphate metabolic process	GO:0019693	291	0.109
guanosine containing compound catabolic process	GO:1901069	144	0.107
regulation of secretion	GO:0051046	274	0.104
nucleoside catabolic process	GO:0009164	206	0.103
nucleotide metabolic process	GO:0009117	332	0.103
aromatic compound catabolic process	GO:0019439	286	0.102
purine nucleoside metabolic process	GO:0042278	241	0.101
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.100
purine nucleotide catabolic process	GO:0006195	211	0.095
calcium ion dependent exocytosis	GO:0017156	35	0.095
cellular macromolecule catabolic process	GO:0044265	206	0.092
purine containing compound metabolic process	GO:0072521	311	0.090
organic cyclic compound catabolic process	GO:1901361	295	0.090
establishment of vesicle localization	GO:0051650	81	0.087
nucleoside triphosphate metabolic process	GO:0009141	230	0.084
nucleobase containing small molecule metabolic process	GO:0055086	352	0.081
regulation of exocytosis	GO:0017157	61	0.078
purine nucleotide metabolic process	GO:0006163	302	0.077
vesicle organization	GO:0016050	60	0.077	Human Yeast
macromolecule catabolic process	GO:0009057	281	0.076
cation transport	GO:0006812	399	0.075
vesicle localization	GO:0051648	86	0.072
neurotransmitter secretion	GO:0007269	62	0.071
gtp metabolic process	GO:0046039	144	0.070
cytoplasmic transport	GO:0016482	234	0.069
carbohydrate derivative catabolic process	GO:1901136	231	0.067
purine nucleoside catabolic process	GO:0006152	205	0.066
nucleotide catabolic process	GO:0009166	217	0.064
nitrogen compound transport	GO:0071705	271	0.064
purine ribonucleoside metabolic process	GO:0046128	241	0.063
organophosphate catabolic process	GO:0046434	232	0.061
vacuole organization	GO:0007033	38	0.060
regulation of vesicle mediated transport	GO:0060627	139	0.056
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.053
regulation of intracellular transport	GO:0032386	159	0.052
regulation of secretion by cell	GO:1903530	249	0.051
glycosyl compound metabolic process	GO:1901657	246	0.051
nucleoside triphosphate catabolic process	GO:0009143	205	0.051
purine ribonucleoside catabolic process	GO:0046130	205	0.050
positive regulation of muscle adaptation	GO:0014744	2	0.047
transmembrane transport	GO:0055085	412	0.046
locomotory behavior	GO:0007626	195	0.044
response to organonitrogen compound	GO:0010243	246	0.044
purine ribonucleotide catabolic process	GO:0009154	208	0.044
autophagic vacuole assembly	GO:0000045	13	0.044
organelle assembly	GO:0070925	177	0.044
ribonucleoside catabolic process	GO:0042454	206	0.044
cellular protein catabolic process	GO:0044257	155	0.044
nucleoside phosphate catabolic process	GO:1901292	222	0.043
protein localization to organelle	GO:0033365	185	0.042
negative regulation of cellular component organization	GO:0051129	194	0.042
cellular nitrogen compound catabolic process	GO:0044270	280	0.041
cellular homeostasis	GO:0019725	240	0.040
ribonucleotide metabolic process	GO:0009259	291	0.039
response to peptide hormone	GO:0043434	127	0.039
g1 s transition of mitotic cell cycle	GO:0000082	57	0.039
nucleoside metabolic process	GO:0009116	246	0.039
regulation of nucleoside metabolic process	GO:0009118	130	0.038
organelle localization	GO:0051640	179	0.037
negative regulation of protein metabolic process	GO:0051248	282	0.037
skeletal muscle organ development	GO:0060538	163	0.037	Mouse
cellular response to organonitrogen compound	GO:0071417	145	0.037
purine containing compound catabolic process	GO:0072523	213	0.036
protein targeting	GO:0006605	143	0.035
cellular chemical homeostasis	GO:0055082	215	0.034
golgi to endosome transport	GO:0006895	3	0.034
response to endoplasmic reticulum stress	GO:0034976	53	0.034
glucocorticoid mediated signaling pathway	GO:0043402	3	0.033
melanosome transport	GO:0032402	11	0.033
positive regulation of nucleotide metabolic process	GO:0045981	114	0.032
organonitrogen compound catabolic process	GO:1901565	264	0.032
glycosyl compound catabolic process	GO:1901658	206	0.032
pigment granule localization	GO:0051875	13	0.031
leukocyte mediated immunity	GO:0002443	174	0.031
cellular ion homeostasis	GO:0006873	165	0.031
cellular response to nutrient levels	GO:0031669	64	0.031
muscle adaptation	GO:0043500	39	0.030
neurotransmitter transport	GO:0006836	76	0.030
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.030
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.029
negative regulation of cellular protein metabolic process	GO:0032269	247	0.029
heterocycle catabolic process	GO:0046700	280	0.028
response to growth factor	GO:0070848	198	0.028
modification dependent protein catabolic process	GO:0019941	133	0.028
glucose homeostasis	GO:0042593	128	0.028
male gamete generation	GO:0048232	285	0.027
regulation of lymphocyte mediated immunity	GO:0002706	84	0.027
olfactory learning	GO:0008355	2	0.027
regulation of synaptic plasticity	GO:0048167	87	0.026
response to peptide	GO:1901652	136	0.026
regulation of organelle organization	GO:0033043	289	0.026
multicellular organismal response to stress	GO:0033555	62	0.026
carbohydrate metabolic process	GO:0005975	230	0.026
thermosensory behavior	GO:0040040	1	0.026
response to topologically incorrect protein	GO:0035966	25	0.026
regulation of hydrolase activity	GO:0051336	246	0.026
positive regulation of hydrolase activity	GO:0051345	148	0.026
spermatid differentiation	GO:0048515	115	0.025
regulation of establishment of protein localization	GO:0070201	181	0.025
protein catabolic process	GO:0030163	221	0.025
small gtpase mediated signal transduction	GO:0007264	97	0.025
spermatogenesis	GO:0007283	284	0.025
negative regulation of secretion	GO:0051048	61	0.024
transmission of nerve impulse	GO:0019226	76	0.024
inorganic ion transmembrane transport	GO:0098660	234	0.024
glycerophospholipid metabolic process	GO:0006650	71	0.024
protein processing	GO:0016485	163	0.023
peptide hormone secretion	GO:0030072	109	0.023
gtp catabolic process	GO:0006184	143	0.023
locomotion involved in locomotory behavior	GO:0031987	8	0.023
negative regulation of t cell mediated cytotoxicity	GO:0001915	3	0.022
amide transport	GO:0042886	138	0.022
cellular response to topologically incorrect protein	GO:0035967	25	0.022
regulation of leukocyte mediated cytotoxicity	GO:0001910	38	0.022
regulation of adaptive immune response	GO:0002819	90	0.022
microtubule based process	GO:0007017	236	0.022
germ cell development	GO:0007281	185	0.022
establishment of synaptic vesicle localization	GO:0097480	57	0.022
regulation of protein transport	GO:0051223	163	0.022
ribonucleotide catabolic process	GO:0009261	208	0.022
glycosylation	GO:0070085	62	0.022
cellular ketone metabolic process	GO:0042180	84	0.021
peptide transport	GO:0015833	133	0.021
regulation of protein localization	GO:0032880	231	0.021
multi multicellular organism process	GO:0044706	109	0.021
insulin secretion	GO:0030073	89	0.021
establishment of protein localization to organelle	GO:0072594	118	0.021
establishment of pigment granule localization	GO:0051905	12	0.021
regulation of purine nucleotide metabolic process	GO:1900542	169	0.020
adaptive immune response	GO:0002250	155	0.020
synaptic vesicle localization	GO:0097479	59	0.020
retrograde vesicle mediated transport golgi to er	GO:0006890	1	0.020
cation transmembrane transport	GO:0098655	266	0.020
multicellular organism growth	GO:0035264	161	0.020
positive regulation of protein modification process	GO:0031401	299	0.020
protein targeting to vacuole	GO:0006623	3	0.020
regulation of hormone levels	GO:0010817	211	0.020
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.019
regulation of cellular amino acid metabolic process	GO:0006521	5	0.019
maintenance of location	GO:0051235	89	0.019
regulation of membrane potential	GO:0042391	192	0.019
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.019
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.019
lymphocyte mediated immunity	GO:0002449	139	0.019
protein kinase b signaling	GO:0043491	74	0.019
chemotaxis	GO:0006935	247	0.019
positive regulation of nucleotide catabolic process	GO:0030813	88	0.019
mitotic cell cycle	GO:0000278	195	0.019
cellularization	GO:0007349	1	0.019
positive regulation of nfat protein import into nucleus	GO:0051533	1	0.019
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.018
positive regulation of intracellular transport	GO:0032388	70	0.018
positive regulation of gtp catabolic process	GO:0033126	85	0.018
positive regulation of hormone secretion	GO:0046887	38	0.018
oxidation reduction process	GO:0055114	342	0.018
hormone secretion	GO:0046879	128	0.018
cellular response to hormone stimulus	GO:0032870	150	0.018
vesicle fusion	GO:0006906	16	0.018	Human Yeast
regulation of proteolysis	GO:0030162	164	0.018
cellular lipid metabolic process	GO:0044255	323	0.018
modification dependent macromolecule catabolic process	GO:0043632	133	0.018
carbohydrate homeostasis	GO:0033500	128	0.018
regulation of cytoplasmic transport	GO:1903649	112	0.018
protein localization to vacuole	GO:0072665	4	0.017
retrograde transport endosome to golgi	GO:0042147	2	0.017
cell cycle g1 s phase transition	GO:0044843	57	0.017
hematopoietic progenitor cell differentiation	GO:0002244	143	0.017
peptide secretion	GO:0002790	114	0.017
spermatid development	GO:0007286	108	0.017
leukocyte mediated cytotoxicity	GO:0001909	62	0.017
establishment of melanosome localization	GO:0032401	11	0.017
posttranscriptional regulation of gene expression	GO:0010608	155	0.017
cellular amine metabolic process	GO:0044106	44	0.017
response to nutrient levels	GO:0031667	109	0.017
ubiquitin dependent protein catabolic process	GO:0006511	129	0.016
leukocyte differentiation	GO:0002521	342	0.016
membrane organization	GO:0061024	245	0.016
lymphocyte proliferation	GO:0046651	164	0.016
synaptic vesicle priming	GO:0016082	8	0.016
positive regulation of nucleoside metabolic process	GO:0045979	91	0.016
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.016
rna splicing	GO:0008380	54	0.016
regulation of peptide transport	GO:0090087	91	0.016
regulation of neurotransmitter levels	GO:0001505	87	0.016
regulation of lymphocyte activation	GO:0051249	240	0.016
regulation of insulin secretion involved in cellular response to glucose stimulus	GO:0061178	31	0.016
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.016
negative regulation of secretion by cell	GO:1903531	54	0.016
protein maturation	GO:0051604	176	0.016
central nervous system neuron differentiation	GO:0021953	162	0.016
rna splicing via transesterification reactions	GO:0000375	43	0.016
second messenger mediated signaling	GO:0019932	73	0.016
regulation of locomotion involved in locomotory behavior	GO:0090325	1	0.016
negative regulation of intracellular signal transduction	GO:1902532	167	0.015
inorganic cation transmembrane transport	GO:0098662	207	0.015
cellular metal ion homeostasis	GO:0006875	151	0.015
learning	GO:0007612	98	0.015
anion transport	GO:0006820	177	0.015
regulation of nucleotide metabolic process	GO:0006140	169	0.015
metal ion homeostasis	GO:0055065	189	0.015
positive regulation of protein transport	GO:0051222	93	0.015
ion transmembrane transport	GO:0034220	361	0.015
multicellular organismal signaling	GO:0035637	91	0.015
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.015
proteasomal protein catabolic process	GO:0010498	98	0.015
organelle fission	GO:0048285	170	0.015
positive regulation of protein phosphorylation	GO:0001934	242	0.014
cation homeostasis	GO:0055080	212	0.014
regulation of neuron differentiation	GO:0045664	281	0.014
t cell mediated immunity	GO:0002456	50	0.014
cognition	GO:0050890	149	0.014
endocytosis	GO:0006897	168	0.014	Yeast
divalent metal ion transport	GO:0070838	172	0.014
regulation of cellular component biogenesis	GO:0044087	181	0.014
neuron death	GO:0070997	154	0.014
carbohydrate derivative biosynthetic process	GO:1901137	183	0.014
muscle tissue development	GO:0060537	308	0.014	Mouse
establishment of protein localization to vacuole	GO:0072666	4	0.014
developmental maturation	GO:0021700	193	0.014
regulation of purine nucleotide catabolic process	GO:0033121	122	0.014
regulation of nucleotide catabolic process	GO:0030811	122	0.014
cellular amino acid metabolic process	GO:0006520	103	0.014
ras protein signal transduction	GO:0007265	77	0.014
cellular response to lipid	GO:0071396	145	0.014
immune effector process	GO:0002252	321	0.014
cellular response to growth factor stimulus	GO:0071363	197	0.013
positive regulation of nervous system development	GO:0051962	221	0.013
negative regulation of protein maturation	GO:1903318	79	0.013
regulation of gtp catabolic process	GO:0033124	113	0.013
regulation of cell killing	GO:0031341	40	0.013
response to oxidative stress	GO:0006979	123	0.013
embryonic organ morphogenesis	GO:0048562	276	0.013
protein autophosphorylation	GO:0046777	61	0.013
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.013
dna recombination	GO:0006310	92	0.013
mitochondrion degradation	GO:0000422	3	0.013
muscle cell differentiation	GO:0042692	261	0.013
regulation of ras gtpase activity	GO:0032318	88	0.013
pigment granule transport	GO:0051904	12	0.013
multi organism behavior	GO:0051705	62	0.013
positive regulation of ras gtpase activity	GO:0032320	65	0.013
synaptic vesicle exocytosis	GO:0016079	26	0.013
relaxation of muscle	GO:0090075	18	0.013
adult locomotory behavior	GO:0008344	91	0.013
associative learning	GO:0008306	61	0.013
positive regulation of purine nucleotide catabolic process	GO:0033123	88	0.013
macromolecule methylation	GO:0043414	120	0.012
smoothened signaling pathway	GO:0007224	105	0.012
cell killing	GO:0001906	67	0.012
response to insulin	GO:0032868	100	0.012
positive regulation of cellular amine metabolic process	GO:0033240	5	0.012
cellular protein complex disassembly	GO:0043624	36	0.012
cellular response to glucose stimulus	GO:0071333	45	0.012
regulation of hormone secretion	GO:0046883	88	0.012
regionalization	GO:0003002	337	0.012
response to oxygen levels	GO:0070482	62	0.012
establishment of organelle localization	GO:0051656	122	0.012
protein import	GO:0017038	101	0.012
regulation of protein processing	GO:0070613	96	0.012
cytokine production	GO:0001816	319	0.012
regulation of protein catabolic process	GO:0042176	108	0.012
regulation of defense response	GO:0031347	233	0.012
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.012
wnt signaling pathway	GO:0016055	188	0.012
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.012
t cell homeostasis	GO:0043029	35	0.012
positive regulation of secretion by cell	GO:1903532	114	0.012
cellular response to external stimulus	GO:0071496	88	0.012
compound eye development	GO:0048749	1	0.012
skeletal muscle cell differentiation	GO:0035914	66	0.011
neuronal action potential	GO:0019228	54	0.011
response to unfolded protein	GO:0006986	21	0.011
regulation of protein targeting	GO:1903533	61	0.011
localization within membrane	GO:0051668	4	0.011
regulation of cellular response to stress	GO:0080135	159	0.011
negative regulation of proteolysis	GO:0045861	74	0.011
regulation of skeletal muscle adaptation	GO:0014733	12	0.011
negative regulation of lymphocyte mediated immunity	GO:0002707	21	0.011
regulation of postsynaptic membrane potential	GO:0060078	48	0.011
cell type specific apoptotic process	GO:0097285	268	0.011
regulation of excitatory postsynaptic membrane potential	GO:0060079	41	0.011
extracellular structure organization	GO:0043062	148	0.011
striated muscle tissue development	GO:0014706	293	0.011	Mouse
glucosamine containing compound metabolic process	GO:1901071	3	0.011
divalent inorganic cation homeostasis	GO:0072507	138	0.011
chromosome organization involved in meiosis	GO:0070192	39	0.011
regulation of organelle assembly	GO:1902115	19	0.011
amine metabolic process	GO:0009308	45	0.011
regulation of t cell mediated immunity	GO:0002709	34	0.011
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	43	0.011
regulation of autophagic vacuole assembly	GO:2000785	4	0.011
nuclear division	GO:0000280	158	0.011
vesicle docking	GO:0048278	7	0.011
regulation of protein localization to nucleus	GO:1900180	60	0.011
striated muscle hypertrophy	GO:0014897	24	0.011
negative regulation of nervous system development	GO:0051961	156	0.011
negative regulation of molecular function	GO:0044092	258	0.011
macroautophagy	GO:0016236	21	0.011
meiotic cell cycle	GO:0051321	122	0.011
activation of rac gtpase activity	GO:0032863	2	0.011
regulation of homeostatic process	GO:0032844	182	0.011
negative regulation of synapse assembly	GO:0051964	3	0.011
cellular response to organic cyclic compound	GO:0071407	87	0.011
regulation of vacuole organization	GO:0044088	4	0.011
defense response to bacterium	GO:0042742	119	0.011
neuron neuron synaptic transmission	GO:0007270	69	0.011
glycerolipid metabolic process	GO:0046486	122	0.011
dephosphorylation	GO:0016311	129	0.011
single organism cell adhesion	GO:0098602	156	0.011
regulation of cellular ketone metabolic process	GO:0010565	66	0.011
t cell differentiation	GO:0030217	174	0.011
defense response to other organism	GO:0098542	197	0.010
mapk cascade	GO:0000165	281	0.010
regulation of apoptotic signaling pathway	GO:2001233	197	0.010
positive regulation of intracellular protein transport	GO:0090316	42	0.010
endoplasmic reticulum unfolded protein response	GO:0030968	19	0.010
positive regulation of secretion	GO:0051047	130	0.010
stem cell differentiation	GO:0048863	268	0.010
positive regulation of cellular component biogenesis	GO:0044089	94	0.010
cellular response to carbohydrate stimulus	GO:0071322	50	0.010
homeostasis of number of cells	GO:0048872	210	0.010
positive regulation of cellular catabolic process	GO:0031331	148	0.010
negative regulation of leukocyte mediated immunity	GO:0002704	29	0.010
mrna processing	GO:0006397	63	0.010
reactive oxygen species metabolic process	GO:0072593	84	0.010
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.010
female meiotic division	GO:0007143	21	0.010
regulation of transferase activity	GO:0051338	263	0.010
regulation of muscle adaptation	GO:0043502	31	0.010

Vamp4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.059
nervous system disease	DOID:863	0.059
central nervous system disease	DOID:331	0.020
eye and adnexa disease	DOID:1492	0.020
eye disease	DOID:5614	0.020
sensory system disease	DOID:0050155	0.020
retinal degeneration	DOID:8466	0.016
retinal disease	DOID:5679	0.016
neurodegenerative disease	DOID:1289	0.015
cancer	DOID:162	0.015
organ system cancer	DOID:0050686	0.015
disease of cellular proliferation	DOID:14566	0.015

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