IMP: Integrative Multi-species Prediction

Mus musculus

96 known processes

Gdf3

growth differentiation factor 3

(Aliases: Gdf-3,MGC123990,Vgr2,ecat9,MGC123991,C78318,Vgr-2)

Entrez: 14562
Ensembl: ENSMUSG00000030117
UniProtKB: Q07104

Process Predictions
Disease Predictions

Gdf3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
urogenital system development	GO:0001655	261	0.959	Mouse Fly
mesendoderm development	GO:0048382	3	0.900
skeletal system morphogenesis	GO:0048705	203	0.896	Mouse
tendon formation	GO:0035992	4	0.859	Mouse
cardiac muscle tissue morphogenesis	GO:0055008	44	0.854	Mouse
primary neural tube formation	GO:0014020	95	0.850	Mouse
appendage morphogenesis	GO:0035107	149	0.847	Mouse Fly
endochondral bone morphogenesis	GO:0060350	50	0.809	Mouse
regulation of organ morphogenesis	GO:2000027	144	0.808	Mouse
adaptive immune response	GO:0002250	155	0.782
neural tube development	GO:0021915	160	0.757	Mouse
embryonic skeletal system development	GO:0048706	120	0.741	Mouse
embryonic appendage morphogenesis	GO:0035113	126	0.738	Mouse
biomineral tissue development	GO:0031214	64	0.735	Mouse
negative regulation of prostatic bud formation	GO:0060686	4	0.729	Mouse
renal system development	GO:0072001	225	0.718	Mouse Fly
immune effector process	GO:0002252	321	0.714
regionalization	GO:0003002	337	0.707
leukocyte differentiation	GO:0002521	342	0.677
anion transport	GO:0006820	177	0.667
morphogenesis of a branching epithelium	GO:0061138	193	0.652	Mouse
forebrain development	GO:0030900	302	0.648	Mouse
response to growth factor	GO:0070848	198	0.647	Mouse
hindlimb morphogenesis	GO:0035137	42	0.636	Mouse
cell fate commitment involved in formation of primary germ layer	GO:0060795	26	0.633	Mouse
amine metabolic process	GO:0009308	45	0.595
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry	GO:1900094	2	0.584
limb development	GO:0060173	166	0.583	Mouse
b cell activation	GO:0042113	161	0.573
skeletal system development	GO:0001501	356	0.552	Mouse
appendage development	GO:0048736	166	0.548	Mouse Fly
t cell activation	GO:0042110	289	0.537
mechanoreceptor differentiation	GO:0042490	67	0.533	Mouse
positive regulation of cell activation	GO:0050867	158	0.532
bmp signaling pathway	GO:0030509	93	0.528	Mouse Fly
positive regulation of lymphocyte activation	GO:0051251	140	0.527
branching morphogenesis of an epithelial tube	GO:0048754	159	0.525	Mouse
stem cell differentiation	GO:0048863	268	0.515	Mouse Fly
neural tube closure	GO:0001843	90	0.511	Mouse
b cell activation involved in immune response	GO:0002312	50	0.506
cellular metal ion homeostasis	GO:0006875	151	0.506
embryonic limb morphogenesis	GO:0030326	126	0.494	Mouse
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.491
angiogenesis	GO:0001525	201	0.481	Mouse
forebrain regionalization	GO:0021871	25	0.476	Mouse
production of molecular mediator of immune response	GO:0002440	103	0.474
cellular amine metabolic process	GO:0044106	44	0.471
bone development	GO:0060348	120	0.469	Mouse
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	61	0.463
epithelial cell proliferation	GO:0050673	174	0.454	Mouse
blood vessel morphogenesis	GO:0048514	285	0.447	Mouse
axial mesodermal cell fate commitment	GO:0048322	1	0.447
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.444
regulation of cell activation	GO:0050865	289	0.442
embryonic epithelial tube formation	GO:0001838	130	0.431	Mouse
defense response to other organism	GO:0098542	197	0.418
positive regulation of epithelial cell proliferation	GO:0050679	68	0.411	Mouse
cell fate commitment	GO:0045165	210	0.410	Mouse Fly
odontogenesis	GO:0042476	78	0.408	Mouse
cellular ion homeostasis	GO:0006873	165	0.405
lymphocyte mediated immunity	GO:0002449	139	0.403
digestive system development	GO:0055123	200	0.401
epithelial tube morphogenesis	GO:0060562	303	0.396	Mouse Fly
diencephalon development	GO:0021536	63	0.393	Mouse
embryonic heart tube development	GO:0035050	65	0.385	Mouse
lymphocyte activation involved in immune response	GO:0002285	93	0.380
defense response to gram positive bacterium	GO:0050830	50	0.380
oxidation reduction process	GO:0055114	342	0.366	Mouse
positive regulation of protein phosphorylation	GO:0001934	242	0.366	Mouse
sensory organ morphogenesis	GO:0090596	242	0.360	Mouse Fly
limb morphogenesis	GO:0035108	149	0.359	Mouse
intracellular receptor signaling pathway	GO:0030522	74	0.356
regulation of embryonic development	GO:0045995	71	0.349	Mouse
positive regulation of stem cell differentiation	GO:2000738	23	0.346	Mouse
b cell mediated immunity	GO:0019724	71	0.339
smad protein signal transduction	GO:0060395	21	0.337	Mouse
endoderm development	GO:0007492	45	0.335
leukocyte activation involved in immune response	GO:0002366	126	0.333
morphogenesis of a branching structure	GO:0001763	203	0.331	Mouse
neural tube formation	GO:0001841	108	0.328	Mouse
myoblast differentiation	GO:0045445	52	0.327
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.325	Mouse
deltoid tuberosity development	GO:0035993	3	0.313	Mouse
striated muscle tissue development	GO:0014706	293	0.309
mesenchymal cell development	GO:0014031	93	0.307	Mouse
embryonic organ morphogenesis	GO:0048562	276	0.304	Mouse
regulation of adaptive immune response	GO:0002819	90	0.302
gland development	GO:0048732	330	0.300	Mouse Fly
nephron development	GO:0072006	109	0.297	Mouse
regulation of mapk cascade	GO:0043408	248	0.296	Mouse
ossification	GO:0001503	216	0.295	Mouse
cardiac chamber morphogenesis	GO:0003206	93	0.295
myotube differentiation	GO:0014902	105	0.295
glomerulus development	GO:0032835	40	0.291	Mouse
mesenchyme morphogenesis	GO:0072132	32	0.290	Mouse
cation homeostasis	GO:0055080	212	0.283
iron ion homeostasis	GO:0055072	36	0.283
determination of left right symmetry	GO:0007368	80	0.282
heart valve development	GO:0003170	23	0.282	Mouse
leukocyte mediated immunity	GO:0002443	174	0.281
central nervous system neuron differentiation	GO:0021953	162	0.279
cellular response to lipid	GO:0071396	145	0.276
regulation of cytokine production	GO:0001817	266	0.275
kidney development	GO:0001822	213	0.274	Mouse
dna metabolic process	GO:0006259	303	0.271
digestive tract morphogenesis	GO:0048546	147	0.268
kidney epithelium development	GO:0072073	121	0.266	Mouse
axial mesodermal cell fate specification	GO:0048327	1	0.265
cation transport	GO:0006812	399	0.264
regulation of epithelial cell proliferation	GO:0050678	141	0.264	Mouse
astrocyte differentiation	GO:0048708	43	0.262	Mouse
blastocyst development	GO:0001824	80	0.261
inner ear receptor cell differentiation	GO:0060113	61	0.260	Mouse
erythrocyte differentiation	GO:0030218	88	0.259	Mouse
forelimb morphogenesis	GO:0035136	40	0.257
regulation of fat cell differentiation	GO:0045598	81	0.257	Mouse
mapk cascade	GO:0000165	281	0.253	Mouse
regulation of wnt signaling pathway	GO:0030111	123	0.249	Mouse
organonitrogen compound biosynthetic process	GO:1901566	192	0.247
stem cell maintenance	GO:0019827	130	0.247	Fly
cartilage development	GO:0051216	140	0.244	Mouse
muscle tissue morphogenesis	GO:0060415	53	0.243	Mouse
cellular homeostasis	GO:0019725	240	0.241
nodal signaling pathway involved in determination of left right asymmetry	GO:0038107	2	0.240
mesenchymal cell differentiation	GO:0048762	107	0.239	Mouse
epithelial tube formation	GO:0072175	130	0.235	Mouse
odontogenesis of dentin containing tooth	GO:0042475	66	0.232	Mouse
cell type specific apoptotic process	GO:0097285	268	0.232
camera type eye development	GO:0043010	266	0.230	Mouse
pericardium development	GO:0060039	16	0.230	Mouse
formation of primary germ layer	GO:0001704	77	0.229	Mouse
myeloid cell differentiation	GO:0030099	233	0.224	Mouse
forebrain neuron differentiation	GO:0021879	52	0.223
embryonic placenta development	GO:0001892	98	0.222
mesoderm formation	GO:0001707	62	0.221	Mouse
determination of heart left right asymmetry	GO:0061371	48	0.220
leukocyte migration	GO:0050900	124	0.219
glial cell differentiation	GO:0010001	131	0.218	Mouse
germ cell development	GO:0007281	185	0.217	Mouse Fly
replacement ossification	GO:0036075	26	0.214	Mouse
developmental maturation	GO:0021700	193	0.211	Fly
head morphogenesis	GO:0060323	34	0.208
divalent inorganic cation transport	GO:0072511	178	0.208
regulation of lymphocyte mediated immunity	GO:0002706	84	0.206
cytokine production	GO:0001816	319	0.205
positive regulation of protein modification process	GO:0031401	299	0.202	Mouse
cell activation involved in immune response	GO:0002263	126	0.202
endodermal cell fate specification	GO:0001714	4	0.200
muscle cell development	GO:0055001	133	0.198
trachea formation	GO:0060440	3	0.198	Mouse
lipid transport	GO:0006869	98	0.196
telencephalon development	GO:0021537	186	0.194	Mouse
regulation of stem cell differentiation	GO:2000736	50	0.192	Mouse
nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry	GO:1900164	2	0.192
determination of left right asymmetry in nervous system	GO:0035545	1	0.190
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.190
embryonic heart tube morphogenesis	GO:0003143	51	0.189
muscle cell proliferation	GO:0033002	52	0.187	Mouse
regulation of gliogenesis	GO:0014013	50	0.186	Mouse
epithelial to mesenchymal transition	GO:0001837	47	0.183	Mouse
alpha beta t cell differentiation	GO:0046632	69	0.183
mesoderm development	GO:0007498	100	0.183
regulation of system process	GO:0044057	200	0.183
proteoglycan metabolic process	GO:0006029	38	0.182	Mouse
cellular chemical homeostasis	GO:0055082	215	0.182
stem cell development	GO:0048864	219	0.180	Mouse Fly
somatic diversification of immune receptors	GO:0002200	53	0.179
t cell differentiation	GO:0030217	174	0.178
regulation of ion transport	GO:0043269	215	0.176
gastrulation	GO:0007369	116	0.175
somitogenesis	GO:0001756	69	0.174
respiratory tube development	GO:0030323	167	0.174	Mouse
cell maturation	GO:0048469	127	0.173	Fly
mesonephric tubule development	GO:0072164	94	0.173	Mouse
male gamete generation	GO:0048232	285	0.172
positive regulation of wnt signaling pathway	GO:0030177	45	0.171	Mouse
morphogenesis of an epithelial fold	GO:0060571	28	0.170	Mouse
positive regulation of mapk cascade	GO:0043410	170	0.170	Mouse
regulation of interleukin 8 production	GO:0032677	3	0.169
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.164	Mouse Fly
multi multicellular organism process	GO:0044706	109	0.161
regulation of t cell activation	GO:0050863	170	0.161
respiratory system development	GO:0060541	190	0.161	Mouse Fly
immunoglobulin mediated immune response	GO:0016064	69	0.160
dna recombination	GO:0006310	92	0.155
action potential	GO:0001508	78	0.154
organic acid transport	GO:0015849	101	0.154
regulation of protein localization	GO:0032880	231	0.154
positive regulation of tendon cell differentiation	GO:2001051	1	0.152
cellular ketone metabolic process	GO:0042180	84	0.152
mesenchyme development	GO:0060485	152	0.147	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	5	0.146
lipid localization	GO:0010876	126	0.146
left lung development	GO:0060459	4	0.144
heart trabecula morphogenesis	GO:0061384	26	0.141
specification of organ position	GO:0010159	3	0.141	Mouse
carbohydrate metabolic process	GO:0005975	230	0.140
glycoprotein metabolic process	GO:0009100	116	0.140	Mouse
spermatogenesis	GO:0007283	284	0.139
cardiac septum development	GO:0003279	59	0.138
regulation of production of molecular mediator of immune response	GO:0002700	65	0.138
ureteric bud morphogenesis	GO:0060675	62	0.135	Mouse
macromolecule methylation	GO:0043414	120	0.134
regulation of chondrocyte differentiation	GO:0032330	33	0.133	Mouse
polarity specification of proximal distal axis	GO:0010085	2	0.133
positive regulation of cell development	GO:0010720	237	0.132	Mouse
mesonephros development	GO:0001823	97	0.132	Mouse
muscle contraction	GO:0006936	101	0.132
myeloid cell homeostasis	GO:0002262	114	0.132	Mouse
atrioventricular valve morphogenesis	GO:0003181	13	0.131	Mouse
skeletal muscle fiber development	GO:0048741	58	0.131
regulation of cell migration	GO:0030334	219	0.130	Mouse
cell differentiation involved in kidney development	GO:0061005	33	0.130	Mouse
negative regulation of epithelial cell proliferation	GO:0050680	64	0.130	Mouse
epiblast cell extraembryonic ectoderm cell signaling involved in anterior posterior axis specification	GO:0060802	1	0.129
carbohydrate derivative biosynthetic process	GO:1901137	183	0.129
epithelial cell differentiation involved in kidney development	GO:0035850	23	0.129	Mouse
cellular response to organic cyclic compound	GO:0071407	87	0.126	Mouse
alpha beta t cell activation	GO:0046631	91	0.125
chloride transport	GO:0006821	32	0.124
multicellular organismal homeostasis	GO:0048871	164	0.123
acute inflammatory response	GO:0002526	41	0.123
mesonephric tubule morphogenesis	GO:0072171	63	0.122	Mouse
lymphocyte proliferation	GO:0046651	164	0.122
response to organic cyclic compound	GO:0014070	198	0.122	Mouse
nephron tubule development	GO:0072080	84	0.121	Mouse
bone mineralization	GO:0030282	54	0.120	Mouse
metal ion homeostasis	GO:0055065	189	0.120
negative regulation of cell proliferation	GO:0008285	296	0.118	Mouse
positive regulation of glial cell differentiation	GO:0045687	21	0.118	Mouse
chondrocyte differentiation	GO:0002062	72	0.118	Mouse
response to acid chemical	GO:0001101	111	0.117
chemotaxis	GO:0006935	247	0.117	Fly
floor plate morphogenesis	GO:0033505	3	0.116
heart valve morphogenesis	GO:0003179	21	0.115	Mouse
regulation of cellular amine metabolic process	GO:0033238	20	0.115
somatotropin secreting cell differentiation	GO:0060126	4	0.115
cardiocyte differentiation	GO:0035051	87	0.115	Fly
stem cell proliferation	GO:0072089	117	0.114	Mouse
cardiac muscle cell differentiation	GO:0055007	69	0.114
positive regulation of nervous system development	GO:0051962	221	0.112	Mouse
body morphogenesis	GO:0010171	45	0.112
positive regulation of dna endoreduplication	GO:0032877	2	0.112
mesoderm morphogenesis	GO:0048332	64	0.111	Mouse
cardiac muscle tissue development	GO:0048738	130	0.111	Mouse
mammary gland morphogenesis	GO:0060443	54	0.111	Mouse
pituitary gland development	GO:0021983	38	0.108	Mouse
regulation of bmp signaling pathway	GO:0030510	60	0.108	Mouse
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	68	0.108
kidney morphogenesis	GO:0060993	83	0.108	Mouse
leukocyte proliferation	GO:0070661	172	0.107
protein modification by small protein conjugation or removal	GO:0070647	207	0.106
cellular modified amino acid metabolic process	GO:0006575	63	0.106
negative regulation of cellular component organization	GO:0051129	194	0.106
negative regulation of embryonic development	GO:0045992	22	0.105	Mouse
b cell differentiation	GO:0030183	78	0.105
metanephric collecting duct development	GO:0072205	7	0.105	Mouse
regulation of kinase activity	GO:0043549	249	0.104
tendon cell differentiation	GO:0035990	4	0.103	Mouse
positive regulation of gliogenesis	GO:0014015	27	0.103	Mouse
neuroepithelial cell differentiation	GO:0060563	37	0.103	Mouse
embryonic digit morphogenesis	GO:0042733	56	0.103	Mouse
maintenance of location	GO:0051235	89	0.102
organic hydroxy compound metabolic process	GO:1901615	203	0.101
cellular carbohydrate metabolic process	GO:0044262	119	0.101
response to fibroblast growth factor	GO:0071774	47	0.101
muscle cell differentiation	GO:0042692	261	0.101
inflammatory response	GO:0006954	244	0.100	Mouse
peptidyl amino acid modification	GO:0018193	336	0.100
cellular response to growth factor stimulus	GO:0071363	197	0.100	Mouse
heart morphogenesis	GO:0003007	178	0.099	Mouse
regulation of striated muscle cell differentiation	GO:0051153	81	0.099
macromolecule catabolic process	GO:0009057	281	0.099
endocardial cushion morphogenesis	GO:0003203	18	0.099	Mouse
positive regulation of erk1 and erk2 cascade	GO:0070374	47	0.098	Mouse
pallium development	GO:0021543	120	0.098
pancreatic a cell fate commitment	GO:0003326	2	0.097
regulation of lymphocyte activation	GO:0051249	240	0.096
chromatin organization	GO:0006325	206	0.096
organophosphate biosynthetic process	GO:0090407	122	0.096
negative regulation of oxidative phosphorylation uncoupler activity	GO:2000276	2	0.095
pancreatic pp cell fate commitment	GO:0003329	2	0.094
myotube cell development	GO:0014904	60	0.094
transmembrane transport	GO:0055085	412	0.094
tube closure	GO:0060606	91	0.093	Mouse
cardiac chamber development	GO:0003205	108	0.093
bone morphogenesis	GO:0060349	78	0.092	Mouse
striated muscle cell development	GO:0055002	125	0.091
somatic cell dna recombination	GO:0016444	51	0.091
neural tube patterning	GO:0021532	43	0.091	Mouse
regulation of cellular ketone metabolic process	GO:0010565	66	0.090
muscle tissue development	GO:0060537	308	0.090
regulation of leukocyte mediated immunity	GO:0002703	104	0.088
muscle system process	GO:0003012	141	0.088
regulation of stem cell maintenance	GO:2000036	17	0.087
dorsal ventral neural tube patterning	GO:0021904	28	0.087	Mouse
neuron death	GO:0070997	154	0.087
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	43	0.086	Mouse
isotype switching	GO:0045190	36	0.086
cell migration involved in gastrulation	GO:0042074	13	0.085
regulation of endothelial cell differentiation	GO:0045601	10	0.084	Mouse
regulation of membrane potential	GO:0042391	192	0.084
morphogenesis of embryonic epithelium	GO:0016331	159	0.084	Mouse Fly
central nervous system neuron development	GO:0021954	67	0.084
developmental growth involved in morphogenesis	GO:0060560	138	0.083	Mouse
positive regulation of immune effector process	GO:0002699	107	0.083
cytokine secretion	GO:0050663	72	0.083
nucleocytoplasmic transport	GO:0006913	139	0.082
regulation of osteoblast differentiation	GO:0045667	67	0.082	Mouse
glycoprotein biosynthetic process	GO:0009101	89	0.082
cellular amino acid metabolic process	GO:0006520	103	0.082
nephron tubule morphogenesis	GO:0072078	68	0.081	Mouse
gliogenesis	GO:0042063	141	0.081	Mouse
regulation of cartilage development	GO:0061035	44	0.081	Mouse
cellular macromolecule catabolic process	GO:0044265	206	0.081
organ growth	GO:0035265	117	0.081	Fly
somatic recombination of immunoglobulin gene segments	GO:0016447	42	0.081
left lung morphogenesis	GO:0060460	3	0.080
ubiquitin dependent protein catabolic process	GO:0006511	129	0.080
amide transport	GO:0042886	138	0.079
somatic diversification of immunoglobulins involved in immune response	GO:0002208	36	0.078
endodermal cell fate commitment	GO:0001711	12	0.078
positive regulation of leukocyte proliferation	GO:0070665	73	0.078
ureteric bud development	GO:0001657	94	0.078	Mouse
cell differentiation in spinal cord	GO:0021515	53	0.077
cell fate specification	GO:0001708	72	0.077	Fly
regulation of hormone levels	GO:0010817	211	0.077
blastocyst formation	GO:0001825	33	0.076
segmentation	GO:0035282	93	0.076
somatic recombination of immunoglobulin genes involved in immune response	GO:0002204	36	0.076
positive regulation of protein kinase activity	GO:0045860	144	0.076
ion transmembrane transport	GO:0034220	361	0.075
fat cell differentiation	GO:0045444	160	0.075	Mouse
fertilization	GO:0009566	127	0.075
inorganic anion transport	GO:0015698	43	0.074
regulation of cytokine secretion	GO:0050707	61	0.074
oogenesis	GO:0048477	56	0.073	Fly
negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis	GO:0072040	4	0.073
protein catabolic process	GO:0030163	221	0.073
genetic imprinting	GO:0071514	27	0.073
endocrine system development	GO:0035270	98	0.072	Mouse
axon guidance	GO:0007411	141	0.071
regulation of chromosome organization	GO:0033044	83	0.071
somatic diversification of immunoglobulins	GO:0016445	43	0.071
positive regulation of epithelial to mesenchymal transition	GO:0010718	13	0.070	Mouse
cerebral cortex development	GO:0021987	86	0.070
homeostasis of number of cells	GO:0048872	210	0.070	Mouse
reactive oxygen species metabolic process	GO:0072593	84	0.070
regulation of organ growth	GO:0046620	61	0.069	Fly
carboxylic acid transport	GO:0046942	100	0.068
regulation of intracellular transport	GO:0032386	159	0.068
dna modification	GO:0006304	50	0.068
negative regulation of stem cell maintenance	GO:1902455	4	0.068
calcium ion transport	GO:0006816	159	0.067
negative regulation of secretion by cell	GO:1903531	54	0.067
multicellular organismal signaling	GO:0035637	91	0.067
embryonic skeletal joint morphogenesis	GO:0060272	11	0.067	Mouse
regulation of establishment of protein localization	GO:0070201	181	0.066
regulation of oxidative phosphorylation uncoupler activity	GO:2000275	3	0.066
myeloid leukocyte differentiation	GO:0002573	119	0.066
positive regulation of osteoblast differentiation	GO:0045669	34	0.066	Mouse
oocyte construction	GO:0007308	2	0.066	Fly
positive regulation of interferon gamma production	GO:0032729	39	0.066
roof plate formation	GO:0021509	1	0.065
negative regulation of cytokine production	GO:0001818	84	0.065
endothelium development	GO:0003158	45	0.065	Mouse
regulation of multicellular organismal metabolic process	GO:0044246	14	0.065
kidney mesenchyme morphogenesis	GO:0072131	4	0.064
hemangioblast cell differentiation	GO:0060217	1	0.064
methylation	GO:0032259	134	0.064
regulation of protein complex assembly	GO:0043254	83	0.064
regulation of secretion	GO:0051046	274	0.063
regulation of b cell mediated immunity	GO:0002712	37	0.063
bundle of his development	GO:0003166	4	0.063
positive regulation of ossification	GO:0045778	47	0.062	Mouse
response to dietary excess	GO:0002021	18	0.062
metanephric mesenchymal cell proliferation involved in metanephros development	GO:0072136	2	0.062
negative regulation of secretion	GO:0051048	61	0.062
mesodermal cell differentiation	GO:0048333	22	0.062	Mouse
axonogenesis	GO:0007409	274	0.061
organic anion transport	GO:0015711	137	0.061
cellular calcium ion homeostasis	GO:0006874	119	0.061
pharynx development	GO:0060465	1	0.061
positive regulation of leukocyte differentiation	GO:1902107	86	0.061
regulation of transferase activity	GO:0051338	263	0.060
endothelial cell differentiation	GO:0045446	41	0.060	Mouse
calcium ion homeostasis	GO:0055074	127	0.060
immunoglobulin production involved in immunoglobulin mediated immune response	GO:0002381	43	0.060
protein modification by small protein conjugation	GO:0032446	187	0.060
regulation of cellular component biogenesis	GO:0044087	181	0.060
auditory receptor cell fate specification	GO:0042667	1	0.059
cardiac ventricle development	GO:0003231	83	0.059
lung development	GO:0030324	164	0.059	Mouse
prostate gland development	GO:0030850	48	0.059	Mouse
cell fate determination	GO:0001709	32	0.059	Mouse
forebrain neuron fate commitment	GO:0021877	13	0.059
ventricular cardiac muscle tissue development	GO:0003229	38	0.059
morphogenesis of an epithelial bud	GO:0060572	18	0.058	Mouse
tissue remodeling	GO:0048771	102	0.058
regulation of receptor activity	GO:0010469	41	0.058
negative regulation of cell development	GO:0010721	169	0.058
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.058
renal tubule development	GO:0061326	87	0.058	Mouse Fly
negative regulation of t cell proliferation	GO:0042130	38	0.057
regulation of cytoplasmic transport	GO:1903649	112	0.057
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.057	Mouse Fly
somite rostral caudal axis specification	GO:0032525	13	0.057
divalent metal ion transport	GO:0070838	172	0.056
nodal signaling pathway	GO:0038092	10	0.056
embryonic axis specification	GO:0000578	30	0.056
cytokine biosynthetic process	GO:0042089	68	0.056
neuronal action potential	GO:0019228	54	0.056
positive regulation of t cell activation	GO:0050870	101	0.056
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.056
trophectodermal cellular morphogenesis	GO:0001831	3	0.056
mesenchymal cell proliferation	GO:0010463	44	0.055	Mouse
digestive tract development	GO:0048565	190	0.055
regulation of protein kinase activity	GO:0045859	232	0.055
tendon development	GO:0035989	6	0.055	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.055
cd4 positive alpha beta t cell activation	GO:0035710	45	0.055
membrane organization	GO:0061024	245	0.055
interspecies interaction between organisms	GO:0044419	83	0.055
response to nutrient levels	GO:0031667	109	0.055
chromatin modification	GO:0016568	187	0.055
positive regulation of neuron differentiation	GO:0045666	141	0.054	Mouse
ear development	GO:0043583	200	0.054	Mouse
corticotropin hormone secreting cell differentiation	GO:0060128	3	0.054	Mouse
protein localization to organelle	GO:0033365	185	0.054
blood circulation	GO:0008015	195	0.054
negative regulation of protein metabolic process	GO:0051248	282	0.054
renal filtration cell differentiation	GO:0061318	10	0.053	Mouse Fly
regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis	GO:0072039	4	0.053
defense response to gram negative bacterium	GO:0050829	28	0.053
cardiac ventricle morphogenesis	GO:0003208	50	0.053
positive regulation of cell migration	GO:0030335	109	0.053	Mouse
nitrogen compound transport	GO:0071705	271	0.053
lymphocyte differentiation	GO:0030098	242	0.052
regulation of immunoglobulin mediated immune response	GO:0002889	37	0.052
protein secretion	GO:0009306	111	0.052
multi organism behavior	GO:0051705	62	0.051
connective tissue development	GO:0061448	179	0.051	Mouse
monocarboxylic acid metabolic process	GO:0032787	191	0.051
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process	GO:2000763	1	0.051
regulation of defense response	GO:0031347	233	0.051
regulation of lipid metabolic process	GO:0019216	118	0.051
embryonic skeletal joint development	GO:0072498	13	0.050	Mouse
cytoplasmic transport	GO:0016482	234	0.050
regulation of leukocyte differentiation	GO:1902105	159	0.050
nephrogenic mesenchyme development	GO:0072076	3	0.050
interleukin 8 production	GO:0032637	4	0.050
positive regulation of fat cell differentiation	GO:0045600	32	0.049	Mouse
insulin secretion	GO:0030073	89	0.049
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.049
g protein coupled receptor signaling pathway	GO:0007186	243	0.049
positive regulation of cardiac muscle cell proliferation	GO:0060045	15	0.049
modification dependent macromolecule catabolic process	GO:0043632	133	0.049
positive regulation of lymphocyte proliferation	GO:0050671	70	0.049
alpha beta t cell differentiation involved in immune response	GO:0002293	30	0.049
sclerotome development	GO:0061056	4	0.049
positive regulation of auditory receptor cell differentiation	GO:0045609	1	0.048
ventricular septum development	GO:0003281	42	0.048
spinal cord motor neuron differentiation	GO:0021522	35	0.048
protein maturation	GO:0051604	176	0.048
negative regulation of cell activation	GO:0050866	111	0.048
positive regulation of cell death	GO:0010942	224	0.048
notch signaling pathway	GO:0007219	71	0.047	Mouse
aromatic compound catabolic process	GO:0019439	286	0.047
regulation of b cell activation	GO:0050864	81	0.047
mesenchymal cell proliferation involved in ureter development	GO:0072198	4	0.047	Mouse
multicellular organismal metabolic process	GO:0044236	28	0.047
forebrain generation of neurons	GO:0021872	63	0.047
positive regulation of semaphorin plexin signaling pathway involved in outflow tract morphogenesis	GO:2000764	1	0.047
anatomical structure homeostasis	GO:0060249	145	0.047
trophectodermal cell differentiation	GO:0001829	21	0.046
placenta development	GO:0001890	140	0.046
calcium mediated signaling	GO:0019722	46	0.046
antimicrobial peptide biosynthetic process	GO:0002777	2	0.046
cardiac atrium morphogenesis	GO:0003209	23	0.046
regulation of chloride transport	GO:2001225	2	0.046
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation	GO:0003257	3	0.046
positive regulation of cell motility	GO:2000147	116	0.045	Mouse
regulation of inflammatory response	GO:0050727	147	0.045
inorganic cation transmembrane transport	GO:0098662	207	0.045
intracellular protein transport	GO:0006886	204	0.045
dna alkylation	GO:0006305	43	0.045
cardiac neural crest cell migration involved in outflow tract morphogenesis	GO:0003253	3	0.045
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.044
regulation of acute inflammatory response	GO:0002673	27	0.044
positive regulation of lymphocyte mediated immunity	GO:0002708	62	0.044
branching involved in ureteric bud morphogenesis	GO:0001658	56	0.044	Mouse
spinal cord development	GO:0021510	81	0.043

Gdf3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
heart disease	DOID:114	0.172
disease of anatomical entity	DOID:7	0.172
cardiovascular system disease	DOID:1287	0.172
immune system disease	DOID:2914	0.057
hematopoietic system disease	DOID:74	0.057

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