Mus musculus

33 known processes

Smc1a

structural maintenance of chromosomes 1A

(Aliases: Smc1alpha,KIAA0178,SMC-1A,5830426I24Rik,mKIAA0178,Smc1l1,Smc1,Sb1.8,Smcb)

Smc1a biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
mitotic sister chromatid cohesionGO:000706410.998
Yeast
synapsisGO:0007129340.997
chromosome organization involved in meiosisGO:0070192390.995
dna endoreduplicationGO:004202340.991
Human
regulation of dna endoreduplicationGO:003287530.990
Human
dna replication independent nucleosome assemblyGO:000633610.989
regulation of transcription by chromatin organizationGO:003440100.984
negative regulation of dna dependent dna replicationGO:200010410.981
Human
negative regulation of dna replicationGO:000815640.975
Human
sister chromatid cohesionGO:0007062120.974
Human Yeast Mouse
meiotic sister chromatid segregationGO:004514460.966
meiosis iiGO:000713570.942
dna dependent dna replication maintenance of fidelityGO:004500530.941
meiotic sister chromatid cohesionGO:005117760.940
synaptonemal complex assemblyGO:0007130130.917
dna metabolic processGO:00062593030.913
Human Yeast
meiotic cell cycle processGO:1903046770.881
chromatin assemblyGO:0031497130.859
regulation of cell cycle processGO:00105641600.841
Human
meiotic nuclear divisionGO:00071261150.832
dna replicationGO:0006260520.800
Human
regulation of nuclear cell cycle dna replicationGO:003326220.755
synaptonemal complex organizationGO:0070193150.755
genetic imprintingGO:0071514270.733
dna conformation changeGO:0071103370.722
seminiferous tubule developmentGO:0072520140.707
dna dependent dna replicationGO:0006261240.689
Human
heterochromatin organizationGO:007082840.677
protein methylationGO:0006479810.677
cellular response to dna damage stimulusGO:00069742070.631
Human Yeast
regulation of chromosome organizationGO:0033044830.614
meiotic cell cycleGO:00513211220.600
histone methylationGO:0016571710.563
double strand break repairGO:0006302480.541
Yeast
chromatin modificationGO:00165681870.508
chromatin organizationGO:00063252060.507
dna packagingGO:0006323300.501
organelle fissionGO:00482851700.494
negative regulation of gene expression epigeneticGO:0045814150.489
male gamete generationGO:00482322850.475
dna repairGO:00062811070.469
Yeast
sister chromatid segregationGO:0000819200.459
Yeast
meiotic chromosome segregationGO:0045132190.452
protein localization to organelleGO:00333651850.446
atp catabolic processGO:0006200550.445
negative regulation of cell cycle processGO:0010948690.441
Human
mitotic sister chromatid segregationGO:0000070140.430
Yeast
recombinational repairGO:0000725210.428
regulation of dna replicationGO:0006275170.416
Human
histone modificationGO:00165701590.408
regulation of cell cycleGO:00517262810.408
Human
male sex differentiationGO:00466611090.400
purine ribonucleoside triphosphate metabolic processGO:00092052200.396
development of primary male sexual characteristicsGO:0046546880.387
purine nucleotide catabolic processGO:00061952110.377
positive regulation of nuclear cell cycle dna replicationGO:001057110.372
nucleoside phosphate metabolic processGO:00067533380.360
microtubule based processGO:00070172360.357
meiosis iGO:0007127600.347
mitotic cell cycle processGO:19030471590.344
Human Yeast
glycosyl compound catabolic processGO:19016582060.334
sertoli cell differentiationGO:0060008180.323
regulation of organelle organizationGO:00330432890.312
anatomical structure homeostasisGO:00602491450.312
regulation of chromatin modificationGO:1903308570.298
chromosome segregationGO:0007059480.278
Human Yeast Mouse Worm
chromatin silencingGO:0006342150.275
nucleoside metabolic processGO:00091162460.271
ribonucleoside monophosphate metabolic processGO:0009161800.271
regulation of cellular ketone metabolic processGO:0010565660.268
jnk cascadeGO:0007254720.267
atp metabolic processGO:0046034750.263
mitotic cell cycleGO:00002781950.261
Human Yeast
regulation of cellular amino acid metabolic processGO:000652150.257
organophosphate catabolic processGO:00464342320.255
cellular amine metabolic processGO:0044106440.251
glycerolipid metabolic processGO:00464861220.247
nucleoside monophosphate metabolic processGO:0009123850.243
cellular ketone metabolic processGO:0042180840.242
reciprocal dna recombinationGO:0035825160.240
ribonucleoside metabolic processGO:00091192450.238
nucleoside triphosphate metabolic processGO:00091412300.237
nucleotide metabolic processGO:00091173320.233
positive regulation of chromosome organizationGO:2001252330.231
male gonad developmentGO:0008584880.229
purine nucleoside monophosphate catabolic processGO:0009128580.226
purine ribonucleoside monophosphate metabolic processGO:0009167800.212
regulation of respiratory system processGO:0044065130.207
nuclear divisionGO:00002801580.206
signal transduction by p53 class mediatorGO:0072331510.205
stem cell differentiationGO:00488632680.202
dna recombinationGO:0006310920.199
nuclear dna replicationGO:003326030.199
negative regulation of cell cycleGO:00457861230.196
Human
ribonucleoside triphosphate metabolic processGO:00091992200.178
regulation of cellular amine metabolic processGO:0033238200.178
purine nucleoside metabolic processGO:00422782410.170
cellular lipid metabolic processGO:00442553230.168
methylationGO:00322591340.165
purine ribonucleoside triphosphate catabolic processGO:00092071990.164
replication fork processingGO:003129710.162
purine ribonucleoside metabolic processGO:00461282410.162
cellular amino acid metabolic processGO:00065201030.161
purine nucleoside triphosphate catabolic processGO:00091462030.161
positive regulation of dna replicationGO:004574090.160
organonitrogen compound catabolic processGO:19015652640.160
glycosyl compound metabolic processGO:19016572460.157
purine ribonucleoside catabolic processGO:00461302050.155
purine ribonucleotide metabolic processGO:00091502900.155
alpha amino acid metabolic processGO:1901605590.154
ribonucleoside monophosphate catabolic processGO:0009158570.153
ribose phosphate metabolic processGO:00196932910.149
positive regulation of homeostatic processGO:0032846640.148
ventricular system developmentGO:0021591270.147
macromolecule methylationGO:00434141200.142
nucleotide catabolic processGO:00091662170.139
purine nucleoside triphosphate metabolic processGO:00091442260.139
chromatin assembly or disassemblyGO:0006333160.138
dna damage response signal transduction by p53 class mediatorGO:0030330190.135
ribonucleotide metabolic processGO:00092592910.135
reciprocal meiotic recombinationGO:0007131160.134
alcohol metabolic processGO:00060661160.132
forebrain developmentGO:00309003020.130
purine ribonucleoside monophosphate catabolic processGO:0009169570.129
nucleobase containing small molecule metabolic processGO:00550863520.126
glycerophospholipid metabolic processGO:0006650710.124
sertoli cell developmentGO:0060009150.124
purine containing compound metabolic processGO:00725213110.124
cellular biogenic amine metabolic processGO:0006576280.124
purine nucleoside monophosphate metabolic processGO:0009126810.120
double strand break repair via homologous recombinationGO:0000724210.120
carbohydrate derivative catabolic processGO:19011362310.117
phosphatidylcholine metabolic processGO:0046470130.115
positive regulation of cellular component biogenesisGO:0044089940.112
covalent chromatin modificationGO:00165691630.111
neuron projection guidanceGO:00974851410.110
protein localization to chromatinGO:007116830.109
stem cell maintenanceGO:00198271300.108
regulation of system processGO:00440572000.107
epithelial cell developmentGO:00020641590.106
cellular response to inorganic substanceGO:0071241370.103
mitotic spindle organizationGO:0007052100.101
axon guidanceGO:00074111410.100
protein dna complex subunit organizationGO:0071824280.099
proprioceptionGO:001923040.098
nucleoside catabolic processGO:00091642060.094
organic hydroxy compound metabolic processGO:19016152030.092
organic cyclic compound catabolic processGO:19013612950.088
negative regulation of neuron apoptotic processGO:0043524920.086
chemotaxisGO:00069352470.086
oxidation reduction processGO:00551143420.084
spermatogenesisGO:00072832840.084
heterochromatin organization involved in chromatin silencingGO:007086810.083
ribonucleoside triphosphate catabolic processGO:00092031990.082
nucleoside phosphate catabolic processGO:19012922220.078
ribonucleotide catabolic processGO:00092612080.076
gonad developmentGO:00084061410.072
Worm
negative regulation of chromosome organizationGO:2001251300.070
negative regulation of cellular amine metabolic processGO:003323910.069
purine nucleoside catabolic processGO:00061522050.068
nitrogen compound transportGO:00717052710.065
regulation of gene expression by genetic imprintingGO:0006349150.065
intracellular mrna localizationGO:000829840.065
peptidyl amino acid modificationGO:00181933360.065
positive regulation of cellular amine metabolic processGO:003324050.063
microtubule cytoskeleton organizationGO:00002261570.063
nucleoside triphosphate catabolic processGO:00091432050.063
mitotic nuclear divisionGO:0007067480.061
Yeast
gene silencingGO:0016458380.060
polyol metabolic processGO:0019751260.060
blastocyst growthGO:0001832230.058
positive regulation of organelle organizationGO:00106381280.057
stress activated protein kinase signaling cascadeGO:0031098810.055
ribonucleoside catabolic processGO:00424542060.055
dna methylation involved in gamete generationGO:0043046150.054
apoptotic signaling pathwayGO:00971903060.053
purine nucleotide metabolic processGO:00061633020.053
negative regulation of cellular amino acid metabolic processGO:004576300.053
axonogenesisGO:00074092740.052
positive regulation of cell cycle processGO:0090068610.051
regulation of cellular response to stressGO:00801351590.051
dendrite developmentGO:00163581150.050
Fly
endocytosisGO:00068971680.050
Worm
aromatic compound catabolic processGO:00194392860.047
regulation of jnk cascadeGO:0046328620.047
protein localization to chromosomeGO:003450260.046
glutamine family amino acid metabolic processGO:0009064150.046
purine ribonucleotide catabolic processGO:00091542080.044
cellular response to cytokine stimulusGO:00713451890.043
response to organonitrogen compoundGO:00102432460.043
mapk cascadeGO:00001652810.043
glutamine metabolic processGO:000654180.042
response to inorganic substanceGO:0010035960.042
regulation of membrane potentialGO:00423911920.042
cell maturationGO:00484691270.041
Fly
heterocycle catabolic processGO:00467002800.040
spindle organizationGO:0007051280.040
stem cell developmentGO:00488642190.040
development of primary sexual characteristicsGO:00451371430.039
Worm
adult locomotory behaviorGO:0008344910.039
intrinsic apoptotic signaling pathwayGO:00971931320.039
nucleosome positioningGO:001658440.039
nucleosome assemblyGO:000633470.037
amine metabolic processGO:0009308450.036
steroid metabolic processGO:00082021190.036
negative regulation of protein modification processGO:00314001630.035
histone lysine methylationGO:0034968500.035
chromatin remodelingGO:0006338320.035
telomere maintenanceGO:0000723190.035
regulation of cell activationGO:00508652890.034
negative regulation of histone modificationGO:0031057180.034
response to light stimulusGO:00094161350.033
Worm
male meiosisGO:0007140370.033
positive regulation of t cell anergyGO:000266940.033
cellular alcohol biosynthetic processGO:004410830.033
regulation of synapse assemblyGO:0051963290.032
purine containing compound catabolic processGO:00725232130.032
signal transduction in response to dna damageGO:0042770210.032
Human
generation of precursor metabolites and energyGO:00060911030.031
protein targetingGO:00066051430.031
catecholamine secretionGO:0050432150.030
bone developmentGO:00603481200.030
negative regulation of cell proliferationGO:00082852960.029
cerebellum developmentGO:0021549770.029
regulation of systemic arterial blood pressureGO:0003073610.029
regulation of cytoplasmic transportGO:19036491120.029
blastocyst developmentGO:0001824800.027
adult behaviorGO:00305341350.027
neurological system process involved in regulation of systemic arterial blood pressureGO:0001976180.027
regulation of isoprenoid metabolic processGO:001974710.027
regulation of cellular component biogenesisGO:00440871810.027
neuromuscular processGO:0050905990.027
heterochromatin assemblyGO:003150720.027
regulation of rna export from nucleusGO:004683140.026
rna polymerase ii transcriptional preinitiation complex assemblyGO:005112330.026
cellular response to organic cyclic compoundGO:0071407870.026
cell type specific apoptotic processGO:00972852680.025
regulation of rna polymerase ii transcriptional preinitiation complex assemblyGO:004589820.025
regulation of intracellular transportGO:00323861590.025
response to oxygen levelsGO:0070482620.025
carbohydrate metabolic processGO:00059752300.025
learningGO:0007612980.024
protein alkylationGO:0008213810.024
positive regulation of protein complex assemblyGO:0031334450.024
leukocyte differentiationGO:00025213420.024
positive regulation of cellular amino acid metabolic processGO:004576430.023
establishment of protein localization to organelleGO:00725941180.023
fertilizationGO:00095661270.023
sensory perceptionGO:00076002450.023
transcription from rna polymerase i promoterGO:0006360130.022
locomotory behaviorGO:00076261950.022
organic hydroxy compound transportGO:0015850930.022
memoryGO:0007613580.022
positive regulation of nervous system developmentGO:00519622210.022
regulation of peptidyl lysine acetylationGO:2000756220.022
negative regulation of cellular component organizationGO:00511291940.021
endomembrane system organizationGO:00102561470.021
cohesin localization to chromatinGO:007192110.021
respiratory system processGO:0003016250.021
g1 s transition of mitotic cell cycleGO:0000082570.021
regulation of chromatin silencingGO:003193520.021
blood circulationGO:00080151950.021
negative regulation of protein processingGO:0010955790.020
protein catabolic processGO:00301632210.020
positive regulation of chromatin modificationGO:1903310280.020
rna localizationGO:0006403230.020
regulation of protein complex assemblyGO:0043254830.020
nucleocytoplasmic transportGO:00069131390.020
cellularizationGO:000734910.020
dna templated transcriptional preinitiation complex assemblyGO:007089740.020
intraspecies interaction between organismsGO:0051703210.019
cardiolipin metabolic processGO:003204830.019
long term memoryGO:0007616150.019
regulation of cohesin localization to chromatinGO:007192210.019
regulation of neuron differentiationGO:00456642810.019
production of molecular mediator of immune responseGO:00024401030.019
cellular respirationGO:0045333380.019
regulation of stress activated mapk cascadeGO:0032872690.019
nuclear transportGO:00511691390.019
regulation of respiratory gaseous exchange by neurological system processGO:0002087120.018
regulation of defense responseGO:00313472330.018
regulation of chromosome segregationGO:0051983210.018
nucleic acid phosphodiester bond hydrolysisGO:0090305490.018
myeloid cell differentiationGO:00300992330.018
histone acetylationGO:0016573410.018
regulation of synaptic growth at neuromuscular junctionGO:000858240.018
mitochondrial electron transport ubiquinol to cytochrome cGO:000612220.018
oocyte axis specificationGO:000730920.018
nuclear importGO:0051170950.018
lateral inhibitionGO:004633110.018
positive regulation of protein modification processGO:00314012990.017
leukocyte proliferationGO:00706611720.017
lymphocyte anergyGO:000224940.017
gonad morphogenesisGO:003526210.017
cellular nitrogen compound catabolic processGO:00442702800.017
cartilage developmentGO:00512161400.017
protein localization to nucleusGO:00345041210.017
chromatin silencing at rdnaGO:000018330.017
intracellular protein transportGO:00068862040.017
ossificationGO:00015032160.017
negative regulation of histone methylationGO:0031061100.017
positive regulation of protein phosphorylationGO:00019342420.016
protein targeting to vacuoleGO:000662330.016
visual learningGO:0008542440.016
regulation of dna dependent dna replicationGO:009032980.016
Human
regulation of lymphocyte activationGO:00512492400.016
regulation of reactive oxygen species biosynthetic processGO:190342620.016
regulation of respiratory gaseous exchangeGO:0043576180.016
modification dependent macromolecule catabolic processGO:00436321330.016
homeostasis of number of cellsGO:00488722100.016
regulation of leukocyte proliferationGO:00706631210.016
neuron apoptotic processGO:00514021420.016
somatic cell dna recombinationGO:0016444510.015
response to lipopolysaccharideGO:00324961280.015
regulation of cell morphogenesis involved in differentiationGO:00107691510.015
membrane organizationGO:00610242450.015
visual behaviorGO:0007632450.015
histone h4 k20 methylationGO:003477080.015
regulation of histone h3 k36 methylationGO:000041410.015
regulation of histone methylationGO:0031060300.015
regulation of excitatory postsynaptic membrane potentialGO:0060079410.015
cellular protein catabolic processGO:00442571550.015
lymphocyte differentiationGO:00300982420.015
cellular response to hormone stimulusGO:00328701500.015
axon target recognitionGO:000741240.015
response to growth factorGO:00708481980.015
histone h3 k4 methylationGO:0051568230.014
positive regulation of rna polymerase ii transcriptional preinitiation complex assemblyGO:004589920.014
heart morphogenesisGO:00030071780.014
membrane depolarizationGO:0051899640.014
regulation of neuron deathGO:19012141340.014
positive regulation of transcription from rna polymerase i promoterGO:004594330.014
protein modification by small protein conjugation or removalGO:00706472070.014
response to peptide hormoneGO:00434341270.014
oocyte constructionGO:000730820.014
regulation of mapk cascadeGO:00434082480.014
internal peptidyl lysine acetylationGO:0018393420.014
regulation of neurotransmitter levelsGO:0001505870.014
negative regulation of neuron deathGO:1901215980.014
negative regulation of protein metabolic processGO:00512482820.014
regionalizationGO:00030023370.013
glial cell migrationGO:000834770.013
rna stabilizationGO:004348990.013
organism emergence from protective structureGO:007168440.013
inflammatory responseGO:00069542440.013
nuclear membrane organizationGO:007176340.013
fat cell differentiationGO:00454441600.013
positive regulation of innate immune responseGO:0045089800.013
peptidyl lysine modificationGO:0018205770.013
protein polymerizationGO:0051258570.013
calcium ion transportGO:00068161590.013
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.013
positive regulation of defense responseGO:00313491240.013
sensory perception of painGO:0019233470.013
regulation of mitotic cell cycle phase transitionGO:1901990730.013
Human
coenzyme biosynthetic processGO:0009108230.013
negative regulation of defense responseGO:0031348770.013
myeloid leukocyte differentiationGO:00025731190.013
maintenance of locationGO:0051235890.013
b cell differentiationGO:0030183780.013
insulin receptor signaling pathwayGO:0008286490.013
cell activation involved in immune responseGO:00022631260.013
multicellular organism growthGO:00352641610.013
developmental maturationGO:00217001930.012
Fly
circulatory system processGO:00030131970.012
cognitionGO:00508901490.012
innate immune responseGO:00450871570.012
immune effector processGO:00022523210.012
negative regulation of synapse assemblyGO:005196430.012
regulation of ketone biosynthetic processGO:001056620.012
associative learningGO:0008306610.012
regulation of cell adhesionGO:00301551540.012
negative regulation of cellular catabolic processGO:0031330470.012
response to decreased oxygen levelsGO:0036293590.012
negative regulation of chromatin modificationGO:1903309190.012
learning or memoryGO:00076111480.012
regulation of protein localizationGO:00328802310.012
regulation of response to woundingGO:19030341890.012
response to inactivityGO:001485440.012
cellular response to peptideGO:1901653920.012
cellular response to sterolGO:003631520.012
histone h3 k9 trimethylationGO:003612460.012
histone h3 k9 dimethylationGO:003612340.012
regulation of innate immune responseGO:0045088910.012
establishment or maintenance of microtubule cytoskeleton polarityGO:003095110.012
respiratory gaseous exchangeGO:0007585430.012
regulation of neuron projection developmentGO:00109751690.011
male anatomical structure morphogenesisGO:009059840.011
positive regulation of cell cycleGO:0045787920.011
nucleoside monophosphate catabolic processGO:0009125590.011
monoamine transportGO:0015844330.011
protein heterotetramerizationGO:005129040.011
response to hypoxiaGO:0001666580.011
regulation of protein targetingGO:1903533610.011
negative regulation of molecular functionGO:00440922580.011
regulation of lymphocyte anergyGO:000291140.011
regulation of circadian sleep wake cycleGO:004274930.011
protein maturationGO:00516041760.011
regulation of t cell anergyGO:000266740.011
mitotic chromosome condensationGO:000707610.011
actin filament organizationGO:00070151130.011
negative regulation of translational initiationGO:004594740.011
response to molecule of bacterial originGO:00022371430.011
regulation of hormone levelsGO:00108172110.011
catecholamine transportGO:0051937210.011
adaptive immune responseGO:00022501550.011
negative regulation of organelle organizationGO:0010639900.011
regulation of leukocyte differentiationGO:19021051590.011
mitochondrial atp synthesis coupled electron transportGO:004277580.011
hindbrain developmentGO:00309021280.010
phospholipid metabolic processGO:0006644870.010
positive regulation of histone methylationGO:0031062160.010
negative regulation of immune system processGO:00026832090.010
phosphatidylglycerol metabolic processGO:004647130.010
cofactor metabolic processGO:0051186800.010
proteolysis involved in cellular protein catabolic processGO:00516031470.010
sensory organ morphogenesisGO:00905962420.010

Smc1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cornelia de lange syndromeDOID:1172500.955
Human
developmental disorder of mental healthDOID:006003700.205
autism spectrum disorderDOID:006004100.205
pervasive developmental disorderDOID:006004000.205
disease of mental healthDOID:15000.205
disease of anatomical entityDOID:700.049
nervous system diseaseDOID:86300.049
congenital nervous system abnormalityDOID:249000.034
physical disorderDOID:008001500.034
autistic disorderDOID:1284900.027
eye and adnexa diseaseDOID:149200.026
sensory system diseaseDOID:005015500.026
immune system diseaseDOID:291400.025
central nervous system diseaseDOID:33100.022
neurodegenerative diseaseDOID:128900.022
eye diseaseDOID:561400.017
retinal diseaseDOID:567900.017
retinal degenerationDOID:846600.013