IMP: Integrative Multi-species Prediction

Mus musculus

18 known processes

Smc1b

structural maintenance of chromosomes 1B

(Aliases: SMC1beta,Smc1l2,SMC-1B)

Entrez: 140557
Ensembl: ENSMUSG00000022432
UniProtKB: Q920F6
UniProtKB: A1L2Z0

Process Predictions
Disease Predictions

Smc1b biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
synapsis	GO:0007129	34	0.879
pirna metabolic process	GO:0034587	12	0.820
male meiosis	GO:0007140	37	0.578
meiosis i	GO:0007127	60	0.549
meiotic cell cycle process	GO:1903046	77	0.402
dna methylation involved in gamete generation	GO:0043046	15	0.330
meiotic cell cycle	GO:0051321	122	0.279
meiotic nuclear division	GO:0007126	115	0.275
chromosome organization involved in meiosis	GO:0070192	39	0.274
fertilization	GO:0009566	127	0.264
dna recombination	GO:0006310	92	0.238
organelle fission	GO:0048285	170	0.173
male gamete generation	GO:0048232	285	0.166
nuclear division	GO:0000280	158	0.154
spermatogenesis	GO:0007283	284	0.138
cellular response to dna damage stimulus	GO:0006974	207	0.122
cellular lipid metabolic process	GO:0044255	323	0.122
dna metabolic process	GO:0006259	303	0.114
response to radiation	GO:0009314	165	0.093
transmembrane transport	GO:0055085	412	0.089
nitrogen compound transport	GO:0071705	271	0.075
regulation of transferase activity	GO:0051338	263	0.071
methylation	GO:0032259	134	0.070
response to light stimulus	GO:0009416	135	0.070
dna repair	GO:0006281	107	0.067
regulation of cellular amine metabolic process	GO:0033238	20	0.066
detection of abiotic stimulus	GO:0009582	60	0.062
ion transmembrane transport	GO:0034220	361	0.062
regulation of membrane potential	GO:0042391	192	0.060
cell maturation	GO:0048469	127	0.056
muscle contraction	GO:0006936	101	0.056
double strand break repair	GO:0006302	48	0.055
macromolecule methylation	GO:0043414	120	0.055
amine metabolic process	GO:0009308	45	0.054
placenta development	GO:0001890	140	0.054
detection of external stimulus	GO:0009581	61	0.053
cofactor transport	GO:0051181	4	0.052
regulation of cellular amino acid metabolic process	GO:0006521	5	0.052
regulation of system process	GO:0044057	200	0.050
cation transmembrane transport	GO:0098655	266	0.050
cellular amino acid metabolic process	GO:0006520	103	0.048
cellular amine metabolic process	GO:0044106	44	0.046
inflammatory response	GO:0006954	244	0.045
muscle system process	GO:0003012	141	0.044
cellular ketone metabolic process	GO:0042180	84	0.044
regionalization	GO:0003002	337	0.042
multicellular organismal signaling	GO:0035637	91	0.041
mapk cascade	GO:0000165	281	0.040
sulfur compound metabolic process	GO:0006790	100	0.040
germ cell development	GO:0007281	185	0.039
dna modification	GO:0006304	50	0.039
stem cell differentiation	GO:0048863	268	0.039	Mouse
t cell activation	GO:0042110	289	0.039
inorganic ion transmembrane transport	GO:0098660	234	0.038
inorganic cation transmembrane transport	GO:0098662	207	0.038
nucleobase containing small molecule metabolic process	GO:0055086	352	0.038
stem cell development	GO:0048864	219	0.038	Mouse
dna alkylation	GO:0006305	43	0.037
regulation of protein kinase activity	GO:0045859	232	0.037
gonad development	GO:0008406	141	0.037
oocyte maturation	GO:0001556	18	0.036
vitamin a metabolic process	GO:0006776	2	0.035
positive regulation of protein modification process	GO:0031401	299	0.035
rhythmic process	GO:0048511	174	0.035
dna methylation	GO:0006306	43	0.035
regulation of cellular ketone metabolic process	GO:0010565	66	0.035
peptidyl amino acid modification	GO:0018193	336	0.034
sensory perception	GO:0007600	245	0.034
exocytosis	GO:0006887	121	0.034
skin development	GO:0043588	220	0.033
developmental maturation	GO:0021700	193	0.033
carbohydrate metabolic process	GO:0005975	230	0.033
epidermis development	GO:0008544	187	0.033
carbohydrate biosynthetic process	GO:0016051	74	0.033
embryonic organ morphogenesis	GO:0048562	276	0.033
diterpenoid metabolic process	GO:0016101	24	0.032
recombinational repair	GO:0000725	21	0.031
cellular chemical homeostasis	GO:0055082	215	0.031
positive regulation of protein phosphorylation	GO:0001934	242	0.030
regulation of ion transport	GO:0043269	215	0.030
mitotic cell cycle process	GO:1903047	159	0.030
cell type specific apoptotic process	GO:0097285	268	0.030
regulation of kinase activity	GO:0043549	249	0.029
regulation of defense response	GO:0031347	233	0.028
synaptonemal complex organization	GO:0070193	15	0.028
oogenesis	GO:0048477	56	0.028
reciprocal dna recombination	GO:0035825	16	0.028
negative regulation of molecular function	GO:0044092	258	0.028
gene silencing by rna	GO:0031047	19	0.027
regulation of cellular component biogenesis	GO:0044087	181	0.027
regulation of interleukin 1 alpha production	GO:0032650	4	0.027
blood circulation	GO:0008015	195	0.027
protein maturation	GO:0051604	176	0.027
reactive oxygen species metabolic process	GO:0072593	84	0.027
nucleotide metabolic process	GO:0009117	332	0.027
chromosome segregation	GO:0007059	48	0.027
circulatory system process	GO:0003013	197	0.026
maintenance of location	GO:0051235	89	0.026
regulation of cell cycle	GO:0051726	281	0.025
negative regulation of phosphorus metabolic process	GO:0010563	184	0.025
cation transport	GO:0006812	399	0.025
cation homeostasis	GO:0055080	212	0.025
negative regulation of cellular protein metabolic process	GO:0032269	247	0.025
organelle localization	GO:0051640	179	0.025
positive regulation of cellular amine metabolic process	GO:0033240	5	0.025
response to lipopolysaccharide	GO:0032496	128	0.025
regulation of ion transmembrane transport	GO:0034765	119	0.025
striated muscle contraction	GO:0006941	45	0.025
regulation of mapk cascade	GO:0043408	248	0.025
chromatin modification	GO:0016568	187	0.024
response to inorganic substance	GO:0010035	96	0.024
oocyte differentiation	GO:0009994	35	0.024
muscle cell differentiation	GO:0042692	261	0.024
camera type eye development	GO:0043010	266	0.024
regulation of mitotic cell cycle	GO:0007346	126	0.023
sequestering of metal ion	GO:0051238	19	0.023
female gamete generation	GO:0007292	74	0.023
protein processing	GO:0016485	163	0.023
blood vessel morphogenesis	GO:0048514	285	0.023
regulation of cell projection organization	GO:0031344	206	0.022
transmission of nerve impulse	GO:0019226	76	0.022
neuronal action potential	GO:0019228	54	0.022
action potential	GO:0001508	78	0.022
sensory perception of mechanical stimulus	GO:0050954	107	0.022
regulation of homeostatic process	GO:0032844	182	0.022
male sex differentiation	GO:0046661	109	0.022
dendrite development	GO:0016358	115	0.022
cellularization	GO:0007349	1	0.022
response to acid chemical	GO:0001101	111	0.022
adult behavior	GO:0030534	135	0.022
positive regulation of thymocyte migration	GO:2000412	2	0.022
immune effector process	GO:0002252	321	0.022
positive regulation of kinase activity	GO:0033674	155	0.021
cellular nitrogen compound catabolic process	GO:0044270	280	0.021
heterocycle catabolic process	GO:0046700	280	0.021
regulation of cell cycle process	GO:0010564	160	0.021
cell adhesion	GO:0007155	329	0.021
intracellular protein transport	GO:0006886	204	0.021
ribonucleoside metabolic process	GO:0009119	245	0.020
mitotic nuclear division	GO:0007067	48	0.020
stem cell maintenance	GO:0019827	130	0.020	Mouse
multicellular organismal homeostasis	GO:0048871	164	0.020
carboxylic acid transport	GO:0046942	100	0.020
retinoid metabolic process	GO:0001523	24	0.020
anion transport	GO:0006820	177	0.020
reciprocal meiotic recombination	GO:0007131	16	0.020
memory	GO:0007613	58	0.020
chromatin organization	GO:0006325	206	0.019
microtubule based process	GO:0007017	236	0.019
hematopoietic progenitor cell differentiation	GO:0002244	143	0.019
glucose homeostasis	GO:0042593	128	0.019
aromatic compound catabolic process	GO:0019439	286	0.019
neuron death	GO:0070997	154	0.019
apoptotic signaling pathway	GO:0097190	306	0.019
cellular response to cytokine stimulus	GO:0071345	189	0.019
macromolecule catabolic process	GO:0009057	281	0.019
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.018
synaptonemal complex assembly	GO:0007130	13	0.018
negative regulation of protein metabolic process	GO:0051248	282	0.018
protein kinase b signaling	GO:0043491	74	0.018
nucleoside phosphate catabolic process	GO:1901292	222	0.018
regulation of inflammatory response	GO:0050727	147	0.018
posttranscriptional regulation of gene expression	GO:0010608	155	0.018
sensory organ morphogenesis	GO:0090596	242	0.018
regulation of response to wounding	GO:1903034	189	0.018
positive regulation of cell development	GO:0010720	237	0.018
mitochondrion organization	GO:0007005	134	0.018
response to peptide	GO:1901652	136	0.018
signal transduction by p53 class mediator	GO:0072331	51	0.018
oxidation reduction process	GO:0055114	342	0.018
organic acid transport	GO:0015849	101	0.017
cognition	GO:0050890	149	0.017
protein localization to organelle	GO:0033365	185	0.017
negative regulation of phosphate metabolic process	GO:0045936	184	0.017
regulation of muscle system process	GO:0090257	80	0.017
nucleocytoplasmic transport	GO:0006913	139	0.016
adult locomotory behavior	GO:0008344	91	0.016
gland development	GO:0048732	330	0.016
protein catabolic process	GO:0030163	221	0.016
oocyte axis specification	GO:0007309	2	0.016
development of primary sexual characteristics	GO:0045137	143	0.016
positive regulation of transferase activity	GO:0051347	167	0.016
regulation of cell migration	GO:0030334	219	0.016
vascular process in circulatory system	GO:0003018	62	0.016
divalent inorganic cation transport	GO:0072511	178	0.016
organic anion transport	GO:0015711	137	0.016
regulation of transmembrane transport	GO:0034762	128	0.016
positive regulation of interleukin 1 alpha production	GO:0032730	4	0.016
olfactory learning	GO:0008355	2	0.016
negative regulation of blood vessel endothelial cell migration	GO:0043537	3	0.016
negative regulation of cell cycle process	GO:0010948	69	0.016
regulation of thymocyte migration	GO:2000410	2	0.016
regulation of secretion by cell	GO:1903530	249	0.015
nucleoside phosphate metabolic process	GO:0006753	338	0.015
locomotory behavior	GO:0007626	195	0.015
purine containing compound catabolic process	GO:0072523	213	0.015
activation of mapk activity involved in innate immune response	GO:0035419	2	0.015
regulation of lipid metabolic process	GO:0019216	118	0.015
leukocyte apoptotic process	GO:0071887	71	0.015
positive regulation of mapk cascade	GO:0043410	170	0.015
amino acid transport	GO:0006865	61	0.015
mitotic cell cycle	GO:0000278	195	0.015
response to oxidative stress	GO:0006979	123	0.015
positive regulation of glutamate secretion	GO:0014049	2	0.015
organelle assembly	GO:0070925	177	0.015
cellular metal ion homeostasis	GO:0006875	151	0.015
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.015
rna interference	GO:0016246	2	0.015
negative regulation of transposition	GO:0010529	2	0.014
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.014
divalent metal ion transport	GO:0070838	172	0.014
glycosyl compound metabolic process	GO:1901657	246	0.014
monocarboxylic acid metabolic process	GO:0032787	191	0.014
epithelial cell development	GO:0002064	159	0.014
organophosphate catabolic process	GO:0046434	232	0.014
development of primary male sexual characteristics	GO:0046546	88	0.014
regulation of hormone levels	GO:0010817	211	0.014
regulation of cellular response to stress	GO:0080135	159	0.014
protein acylation	GO:0043543	64	0.014
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.014
cytoplasmic transport	GO:0016482	234	0.014
male meiosis i	GO:0007141	16	0.014
glycerolipid metabolic process	GO:0046486	122	0.014
negative regulation of protein modification process	GO:0031400	163	0.014
response to molecule of bacterial origin	GO:0002237	143	0.014
purine nucleotide metabolic process	GO:0006163	302	0.014
sequestering of calcium ion	GO:0051208	18	0.014
sensory perception of light stimulus	GO:0050953	54	0.014
intracellular mrna localization	GO:0008298	4	0.014
cardiac muscle cell contraction	GO:0086003	7	0.014
negative regulation of cell cycle phase transition	GO:1901988	48	0.014
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.014
mitotic cytokinesis	GO:0000281	4	0.014
regulation of dna endoreduplication	GO:0032875	3	0.014
negative regulation of endothelial cell migration	GO:0010596	4	0.013
multi multicellular organism process	GO:0044706	109	0.013
gene silencing	GO:0016458	38	0.013
meiotic sister chromatid segregation	GO:0045144	6	0.013
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.013
muscle tissue development	GO:0060537	308	0.013
regulation of proteolysis	GO:0030162	164	0.013
positive regulation of membrane protein ectodomain proteolysis	GO:0051044	3	0.013
calcium ion transmembrane transport	GO:0070588	85	0.013
meiosis ii	GO:0007135	7	0.013
regulation of organelle organization	GO:0033043	289	0.013
reactive oxygen species biosynthetic process	GO:1903409	8	0.013
regulation of eosinophil migration	GO:2000416	2	0.013
eosinophil migration	GO:0072677	3	0.013
muscle cell development	GO:0055001	133	0.013
oocyte construction	GO:0007308	2	0.013
purine containing compound metabolic process	GO:0072521	311	0.013
purine ribonucleotide metabolic process	GO:0009150	290	0.013
regulation of tube size	GO:0035150	57	0.013
negative regulation of cell cycle	GO:0045786	123	0.013
urogenital system development	GO:0001655	261	0.013
carbohydrate derivative catabolic process	GO:1901136	231	0.013
neuromuscular process	GO:0050905	99	0.013
skeletal system development	GO:0001501	356	0.013
oocyte development	GO:0048599	33	0.013
single fertilization	GO:0007338	82	0.013
synaptic transmission	GO:0007268	329	0.013
positive regulation of programmed cell death	GO:0043068	218	0.013
myelination	GO:0042552	74	0.013
male germ line stem cell asymmetric division	GO:0048133	2	0.013
activation of immune response	GO:0002253	138	0.013
terpenoid metabolic process	GO:0006721	25	0.013
regulation of secretion	GO:0051046	274	0.013
carbohydrate homeostasis	GO:0033500	128	0.012
leukocyte migration	GO:0050900	124	0.012
cellular response to lipid	GO:0071396	145	0.012
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.012
retina morphogenesis in camera type eye	GO:0060042	45	0.012
metal ion homeostasis	GO:0055065	189	0.012
learning or memory	GO:0007611	148	0.012
regulation of protein kinase b signaling	GO:0051896	56	0.012
ribonucleotide catabolic process	GO:0009261	208	0.012
positive regulation of protein kinase activity	GO:0045860	144	0.012
negative regulation of mitotic cell cycle	GO:0045930	58	0.012
regulation of neuron projection development	GO:0010975	169	0.012
regulation of apoptotic signaling pathway	GO:2001233	197	0.012
hepaticobiliary system development	GO:0061008	67	0.011
glycosylation	GO:0070085	62	0.011
regulation of binding	GO:0051098	111	0.011
cytokine production	GO:0001816	319	0.011
organonitrogen compound catabolic process	GO:1901565	264	0.011
membrane depolarization	GO:0051899	64	0.011
reactive nitrogen species metabolic process	GO:2001057	0	0.011
rna processing	GO:0006396	105	0.011
small gtpase mediated signal transduction	GO:0007264	97	0.011
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.011
positive regulation of cellular component biogenesis	GO:0044089	94	0.011
adaptive immune response	GO:0002250	155	0.011
positive regulation of meiosis i	GO:0060903	5	0.011
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.011
nucleoside metabolic process	GO:0009116	246	0.011
macromolecule glycosylation	GO:0043413	55	0.011
regulation of reproductive process	GO:2000241	66	0.011
cellular response to peptide hormone stimulus	GO:0071375	92	0.011
positive regulation of nervous system development	GO:0051962	221	0.011
double strand break repair via homologous recombination	GO:0000724	21	0.011
glycoprotein metabolic process	GO:0009100	116	0.011
protein glycosylation	GO:0006486	55	0.011
ribonucleotide metabolic process	GO:0009259	291	0.011
negative regulation of phosphorylation	GO:0042326	166	0.011
negative regulation of protein phosphorylation	GO:0001933	126	0.011
regulation of cell motility	GO:2000145	236	0.011
protein modification by small protein conjugation or removal	GO:0070647	207	0.011
negative regulation of mitotic cell cycle phase transition	GO:1901991	45	0.011
thymocyte migration	GO:0072679	2	0.011
cofactor metabolic process	GO:0051186	80	0.011
detection of light stimulus	GO:0009583	25	0.011
regulation of muscle contraction	GO:0006937	49	0.011
positive regulation of t cell activation	GO:0050870	101	0.011
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.011
ear development	GO:0043583	200	0.011
regulation of cell cycle phase transition	GO:1901987	77	0.011
organic cyclic compound catabolic process	GO:1901361	295	0.011
regulation of transcription by chromatin organization	GO:0034401	0	0.011
neural tube development	GO:0021915	160	0.011
nucleoside triphosphate metabolic process	GO:0009141	230	0.011
peptide metabolic process	GO:0006518	46	0.010
triglyceride metabolic process	GO:0006641	51	0.010
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.010
positive regulation of leukocyte differentiation	GO:1902107	86	0.010
actin filament based movement	GO:0030048	23	0.010
regulation of interleukin 1 alpha secretion	GO:0050705	3	0.010
purine ribonucleotide catabolic process	GO:0009154	208	0.010
intrinsic apoptotic signaling pathway	GO:0097193	132	0.010
negative regulation of dna dependent dna replication	GO:2000104	1	0.010
pma inducible membrane protein ectodomain proteolysis	GO:0051088	1	0.010
nucleotide catabolic process	GO:0009166	217	0.010
purine ribonucleoside metabolic process	GO:0046128	241	0.010
negative regulation of gene silencing	GO:0060969	2	0.010
axonogenesis	GO:0007409	274	0.010
nucleoside monophosphate metabolic process	GO:0009123	85	0.010
compound eye development	GO:0048749	1	0.010

Smc1b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.054
disease of anatomical entity	DOID:7	0.054
sensory system disease	DOID:0050155	0.054
eye and adnexa disease	DOID:1492	0.041
eye disease	DOID:5614	0.022
retinal disease	DOID:5679	0.019
disease of cellular proliferation	DOID:14566	0.017
disease of metabolism	DOID:0014667	0.013
cancer	DOID:162	0.011

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